A system and method for treating congestive heart failure in a patient, including: implanting at least one pressure sensor in a desired location within the patient; providing an ex- vivo interrogation system and monitoring system that can be configured to optionally affect at least one of: selectively energizing the at one pressure sensor, receiving a return or output signal from the at one pressure sensor, processing the return signal, and displaying processed data derived from the at least one pressure sensor to a physician. The system and method also includes deriving diagnostic and treatment information from the processed data and sending diagnostic and treatment information to the patient.
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A method for monitoring data in a clinical environment comprises receiving information indicative of a number of ambulatory sensing systems in a measurement environment comprising a plurality of ambulatory sensing systems. The method also comprises establishing a communication scheme associated with the measurement environment based on the number of ambulatory sensing systems in the measurement environment. The method further comprises providing, to each ambulatory sensing system, information indicative of the established communication scheme. The method also comprises configuring, in a central data module associated with the measurement environment, parameters for communicating with each respective ambulatory sensing system in accordance with the established control scheme.
G01B 7/04 - Dispositions pour la mesure caractérisées par l'utilisation de techniques électriques ou magnétiques pour mesurer la longueur, la largeur ou l'épaisseur spécialement adaptés pour mesurer la longueur ou la largeur d'objets en mouvement
3.
METHODS FOR THE TREATMENT OF CARDIOVASCULAR CONDITIONS
Provided herein are methods and systems for the treatment of cardiovascular conditions, including pulmonary hypertension (PH), in subjects that are being treated with a phosphodiesterase-S (PDE-5) inhibitor. For example, provided are methods of evaluating the progression or improvement of a cardiovascular condition in a subject being administered a treatment regimen that includes a PDE-5 inhibitor, or predicting an outcome in a subject being administered a treatment regimen that includes PDE-5 inhibitor. Methods can include obtaining one or more pulmonary arterial (PA) hemodynamic readings comprising a PA hemodynamic waveform from the subject using an implantable pressure sensor, processing the PA hemodynamic waveform to obtain a cardiovascular parameter, and comparing the cardiovascular parameter obtained from the subject to a standard to determine or predict the progression of the cardiovascular condition, the improvement of the cardiovascular condition, the outcome of the cardiovascular condition, or a combination thereof.
Provided herein are devices, systems, and methods for assessing, treating, and for developing new treatments for pulmonary arterial hypertension (PAH) using pulmonary artery pressure (PAP) values and/or cardiac output (CO) estimates. The system for evaluating progress of pulmonary arterial hypertension (PAH) includes a device configured to obtain a pulmonary artery pressure waveform, a processor, and a memory coupled to the processor. The memory causes the processor to receive the pulmonary artery pressure waveform, determine one or more pulmonary artery pressure (PAP) values, and estimate cardiac output (CO).
The present disclosure is directed to a system having a database operable to receive at least one physiological parameter data from at least one of an electronic medical record (EMR) portal configured for receiving EMR data from an electronic medical record; a healthcare provider (HCP) portal configured for receiving HCP data; a patient portal configured for receiving patient data; and a medical device portal configured for receiving medical device data; for calculating secondary parameters from scoring algorithms, trend algorithms, parameter algorithms and treatment algorithms; then displaying the data and secondary parameters in a graphical format in order to for detect, diagnose and treat chronic disease in patients.
Provided herein are methods for assessing, treating, and for developing new treatments for COPD. Methods can involve obtaining one or more PA hemodynamic readings from a subject with COPD, processing the PA hemodynamic readings to obtain one or more PA hemodynamic parameters, and using the one or more PA hemodynamic parameters to assess, treat, and/or develop new treatments for COPD. The methods can optionally be used to evaluate the progress of (COPD) in a subject, or to predict an outcome in a subject having COPD.
Systems and methods using a database of physiological information for the design, development, testing and use of therapeutics. In one aspect, the physiological information can include at least one of: hemodynamic monitoring information, pulmonary arterial pressure, cardiac output, heart rate, respiratory rate, peripheral vascular resistance, total peripheral resistance or dicrotic notch information. Optionally, the cardiovascular physiology information can include ambulatory physiological information.
G06Q 50/00 - Technologies de l’information et de la communication [TIC] spécialement adaptées à la mise en œuvre des procédés d’affaires d’un secteur particulier d’activité économique, p. ex. aux services d’utilité publique ou au tourisme
G06F 17/40 - Acquisition et consignation de données
A wireless sensor having a primary passive electrical resonant circuit that has an intrinsic electrical property that is variable in response to a characteristic of a patient and a secondary passive electrical resonant circuit. In one aspect, the primary passive resonant circuit can be positioned into a tuned position in response to the actuation of the secondary passive electrical resonant circuit. In a further aspect, in the tuned position, the primary passive electrical resonant circuit, in response to an energizing signal produced by an ex- vivo source of RF energy, is configured to generate a sensor signal characterized by a resonant frequency that is indicative of the characteristic.
A ventricular shunt systems and methods of preventing hydrocephalus are described herein. In one aspect, the ventricular shunt system has at least one pressure sensor that is configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy and is variable in response to the pressure in a patient's ventricle.
A61M 25/088 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters utilisant un cathéter supplémentaire, p. ex. pour atteindre des endroits relativement inaccessibles
A61B 5/027 - Mesure du débit sanguin utilisant des moyens électromagnétiques, p. ex. débitmètre électromagnétique utilisant des cathéters
Disclosed are hypertension systems and related methods that include a blood pressure sensor located or implanted under the skin of a patient, and electronics, which may have the size and shape of a wrist watch, for example, that monitors the blood pressure of the patient by communicating with the implanted sensor.
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/0215 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par des moyens introduits dans le corps
A61B 5/053 - Mesure de l'impédance ou de la conductivité électrique d'une partie du corps
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
[encoded electronic chip cards containing medical and pharmaceutical product and patient data] medical diagnostic sensors for measuring properties of the body, namely, pressure or temperature, corresponding catheter-based delivery apparatus to deliver sensors to locations within the body; telemetry devices for medical application and software to interrogate, receive, process and display pressure or temperature data or derived quantities for viewing and printing sold as a unit [surgical drapes]
12.
PHYSICAL PROPERTY SENSOR WITH ACTIVE ELECTRONIC CIRCUIT AND WIRELESS POWER AND DATA TRANSMISSION
Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment, m one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.
This application relates to an apparatus and system for sensing strain on a portion of an implant positioned in a living being. In one aspect, the apparatus has at least one sensor assembly that can be mountable thereon a portion of the implant and that has a passive electrical resonant circuit that can be configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy. Each sensor assembly, in response to the electromagnetic coupling, can be configured to generate an output signal characterized by a frequency that is dependent upon urged movement of a portion of the passive electrical resonant circuit and is indicative of strain applied thereon a portion of the respective sensor assembly.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G01L 1/20 - Mesure des forces ou des contraintes, en général en mesurant les variations de la résistance ohmique des matériaux solides ou des fluides conducteurs de l'électricitéMesure des forces ou des contraintes, en général en faisant usage des cellules électrocinétiques, c.-à-d. des cellules contenant un liquide, dans lesquelles un potentiel électrique est produit ou modifié par l'application d'une contrainte
14.
SYSTEM AND APPARATUS FOR IN-VIVO ASSESSMENT OF RELATIVE POSITION OF AN IMPLANT
A system and apparatus for providing an in- vivo assessment of relative movement of an implant that is positioned in a living being is provided that comprises a first assembly and a second assembly that are positioned within the living being. The first assembly comprises a passive electrical resonant circuit that is configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy and, in response to the electromagnetic coupling, generates an output signal characterized by a frequency that is dependent upon a distance between the first assembly and the second assembly at the time of the electromagnetic coupling.
A61B 17/70 - Dispositifs de mise en position ou de stabilisation de la colonne vertébrale, p. ex. stabilisateurs comprenant un liquide de remplissage dans un implant
A61F 2/44 - Articulations pour l'épine dorsale, p. ex. vertèbres, disques intervertébraux
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
A communication system for communicating with an implanted wireless sensor is provided. A transmit antenna element can propagate an energizing signal onto a communication medium and a receive antenna element can recover a responsive implanted sensor response signal. The antenna box (204) includes a power amplifier for amplifying the energizing signal and timing regeneration circuitry for detecting an end to signals and outputting control signals for selecting mode operation. The antenna box can receive the energizing signal from the antenna cable (208) in a transmit mode and provide the implanted sensor response signal to the antenna cable in a receive mode. The antenna box can communicate with an electronic box (210) and/or conversion box (206) that provide and receive signals and provide power via the antenna cable.
Aspects and embodiments of the present invention provide a loosely-coupled oscillator including a sensor circuit and an electronic device that are not physically connected. In some embodiments, the electronic device includes an amplifier stage and a feedback network and the sensor circuit includes one or more LC circuits. When electromagnetically connected, the sensor circuit and electronic device form an oscillator that is adapted to output an oscillation signal. The resonant frequency of the sensor circuit can be obtained based on the oscillation signal. The sensor circuit may be implanted into an object and the resonant frequency of the sensor circuit can be used to determine characteristics of the object.
G01D 5/12 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques
A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.
G01L 9/12 - Mesure de la pression permanente, ou quasi permanente d’un fluide ou d’un matériau solide fluent par des éléments électriques ou magnétiques sensibles à la pressionTransmission ou indication par des moyens électriques ou magnétiques du déplacement des éléments mécaniques sensibles à la pression, utilisés pour mesurer la pression permanente ou quasi permanente d’un fluide ou d’un matériau solide fluent en faisant usage des variations de la capacité
18.
METHOD AND APPARATUS FOR MEASURING PRESSURE INSIDE A FLUID SYSTEM
A disclosed method determines fluid pressure inside a vessel without compromising the integrity of the vessel. A sensor is positioned in operative communication with the external wall of the vessel such that expansion of the external wall of the vessel exerts a force against the sensor that is directed substantially radially outward with respect to the vessel. A substantially radially inward force is caused to be directed against the sensor in response to the substantially radially outward force exerted by the external vessel wall. The sensor can thus be used to detect the magnitude of the substantially radially outward force. A disclosed apparatus determines fluid pressure inside a vessel without compromising the integrity of the vessel. The apparatus includes a sensor and a band operatively associated with the sensor and configured to at least partially encircle the vessel so as to retain the sensor in operative communication against the external wall of the vessel.
Aspects and embodiments of the present invention provide a system for obtaining, processing and managing data from an implanted sensor. In some embodiments, a patient or other persons can use a flexible antenna to obtain data from the implanted sensor. The flexible antenna includes at least one transmit loop and at least one receive loop. The transmit loop is adapted to propagate energizing signals to the implanted sensor. The receive loop is adapted to detect a response signal from the implanted sensor. The transmit loop includes a capacitor formed by a discontinuous area. The capacitor is adapted to allow the loop to be tuned. The flexible antenna can communicate with a patient device that collects the data from the implanted sensor, creates a data file and transmits the data file to a remote server over a network. A physician or other authorized person may access the remote server using an access device.
Embodiments of the present invention are directed to a cable assembly that is adapted to be connected to an antenna and a base unit. The cable assembly may be relatively flat with shielding and structures to reduce ground currents or other interference. Embodiments of the cable assembly include at least two coaxial cables for transmit and receive signals that are separated to reduce crosstalk or other interference. The cable may also include one or more inner cables, such as differential or switching pairs, between the two coaxial cables to provide cables for control, power, switching, or other functions. The inner cables may be positioned in parallel to each other and to each of the coaxial cables. In some embodiments, the inner cables include a first inner cable located at a first end of the inner cables and a second inner cable located at a second end of the inner cables. One coaxial cable may be positioned adjacent and parallel to the first inner cable, which the other coaxial cable may be positioned adjacent and parallel to the second inner cable.
A method and apparatus for determining cardiac parameters within the body of a patient includes a wireless sensor positioned in the patient's pulmonary artery. An external RF telemetry device communicates wirelessly with the sensor and interrogates the sensor to determine changes in pressure in the pulmonary artery over time. The peak pressure difference is determined. Then, assuming zero blood flow velocity at the time of valve opening and at the time of valve closing, a velocity-time function is determined. The velocity-time function is used to determine a velocity-time integral. The velocity-time integral is then used to determine cardiac stroke volume. The cardiac stroke volume is multiplied times the heartbeat rate to determine cardiac output. The cardiac output can be monitored over time to determine continuous cardiac output.
Aspects of the present invention determine the resonant frequency of a sensor by obtain sensor signals in response to three energizing signals, measure the phase of each sensor signal, and using a group phase delay to determine the resonant frequency. The phase difference between the first and second signal is determined as a first group phase delay. The phase difference between the second and third signal is determined as a second group phase delay. The first group phase delay and second group phase delay are compared. Based on the comparison, the system may lock on the resonant frequency of the sensor or adjust a subsequent set of three energizing signals.
An implant assembly for releasing into a vessel at an implant location includes an intracorporeal device and an anchor. The anchor comprises a pair of resiliently deformable loops operatively associated with the intracorporeal device, both of the loops extending toward the same side of a plane defined by the intracorporeal device. The deformable loops have a relaxed state and a deformed state. When the deformable loops are in a relaxed state, the implant assembly has a major dimension in a direction out of the plane that is greater than the diameter of a vessel at the implant location. The loops are deformable to permit insertion of the implant assembly into the vessel. The tendency of the loops to return to their relaxed state exerts a force on a wall of the vessel that imposes the intracorporeal device against an opposite wall of the vessel.
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Implantable medical sensors, namely fluid pressure and temperature sensors, intended for diagnostic use.
(2) Medical diagnostic sensors, namely, implantable wireless pressure or temperature sensors, corresponding catheter-based delivery apparatus to deliver medical diagnostic sensors to locations within the body and recordable data carriers, namely, identification cards with embedded chips to relay patient data and sensor calibration information; telemetry devices and computer software sold as a unit for measuring, receiving, processing, displaying, and printing pressure or temperature data produced by medical diagnostic sensors; surgical drapes.
