The present invention relates to a sterile hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide or a mixture thereof, in particular comprising a cross-linked hyaluronic acid, a non-cross-linked hyaluronic acid or a mixture thereof, and further comprising zinc and citrate ions, as well as to a method for preparing same.
The disclosure provides a method for preparing a sterile hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide, or a mixture thereof, the method comprising the steps of: (1) preparing a hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide or a mixture thereof and further comprising at least 1 mM citrate ions; and (2) sterilizing, preferably heat sterilizing, the hydrogel comprising at least 1 mM citrate ions to obtain a sterile hydrogel comprising a cross-linked polyssaccharide, a non-cross-linked polysaccharide or a mixture thereof.
G01N 11/10 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement en déplaçant un corps à l'intérieur du matériau
C08J 3/24 - Réticulation, p.ex. vulcanisation, de macromolécules
A61Q 19/00 - Préparations pour les soins de la peau
G01N 11/10 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement en déplaçant un corps à l'intérieur du matériau
The present invention relates to a method for producing a hydrogel comprising a cross-linked polysaccharide, in particular, a method for producing an injectable hydrogel containing cross-linked hyaluronic acid. The present invention also relates to a hydrogel, preferably injectable, that can be obtained by the method, a composition containing the hydrogel, and the uses of said hydrogel.
The present invention relates to a method for producing a hydrogel comprising a cross-linked polysaccharide, in particular, a method for producing an injectable hydrogel comprising cross-linked hyaluronic acid. The present invention also relates to a hydrogel, preferably injectable, that can be obtained by the method, a composition containing the hydrogel, and the uses of said hydrogel.
C08J 3/24 - Réticulation, p.ex. vulcanisation, de macromolécules
A61Q 19/00 - Préparations pour les soins de la peau
G01N 11/10 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement en déplaçant un corps à l'intérieur du matériau
The present invention relates to a method for producing a hydrogel comprising a cross-linked polysaccharide, in particular, a method for producing an injectable hydrogel comprising cross-linked hyaluronic acid. The hydrogel has mechanical properties suitable for filling soft tissues. The present invention also relates to a hydrogel, preferably injectable, that can be obtained by the method and a composition containing the hydrogel.
Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt thereof; and an effective amount of at least mepivacaine or a salt thereof are provided. The hyaluronic acid optionally has an average molecular weight ranging from 50,000 to 10,000,000 Daltons, and may be crosslinked hyaluronic acids, non-crosslinked hyaluronic acids, or a combination, in some embodiments. The compositions and methods of the present invention are useful for treating and preventing the cutaneous signs of chronological aging and/or induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure, impaired surface appearance of the skin, impaired viscoelastic or biomechanical properties of the skin, and/or the long-lasting filling of volume defects of the skin.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
A61K 31/451 - Pipéridines non condensées, p.ex. pipérocaïne ayant un carbocycle lié directement à l'hétérocycle, p.ex glutéthimide, mépéridine, lopéramide, phencyclidine, piminodine
The invention has for object a method of selecting a composition comprising crosslinked hyaluronic acid (HA) and a low proportion of soluble hyaluronic acid for use in limiting the risk of appearance of an adverse side effect associated with the administration of a composition comprising crosslinked HA.
The present invention relates to a process for preparing a hydrogel, comprising the following steps: a) provision of a polysaccharide or a salt thereof; b) crosslinking of the polysaccharide in the presence of 0.05 to 10 mol%, preferentially 0.1 to 2 mol%, of at least one crosslinking agent, or a salt thereof, per 1 mol of repeat units of the polysaccharide; c) functionalisation of the polysaccharide with at least one silylated molecule of formula Chem. I or a salt thereof; d) sol-gel reaction of at least one part of the Si-OR10groups and optionally at least one part of the SiOR4 groups of the molecule of formula Chem. I or a salt thereof when they are present.
A61K 31/715 - Polysaccharides, c. à d. ayant plus de cinq radicaux saccharide liés les uns aux autres par des liaisons glycosidiques; Leurs dérivés, p.ex. éthers, esters
The present invention relates to a hyaluronic acid-based aqueous gel comprising crosslinked hyaluronic acid and from 30 to 70% by mass with respect to the total mass of hyaluronic acid, of a water-soluble hyaluronic acid. The present invention relates to a method for preparing an aqueous gel comprising at least a crosslinked hyaluronic acid and at least an uncrosslinked hyaluronic acid. The present invention also concerns an aqueous gel obtainable by said method compositions, a cosmetic and/or dermatological composition comprising said aqueous gels, and a kit comprising a pre-filled syringe comprising said aqueous gel or said composition. These gels and compositions are useful in particular for treating an alteration in the surface appearance of the skin and/or for augmenting and/or filling soft tissue.
The present invention relates to a hyaluronic acid-based aqueous gel comprising crosslinked hyaluronic acid and from 30 to 70% by mass with respect to the total mass of hyaluronic acid, of a water-soluble hyaluronic acid. The present invention relates to a method for preparing an aqueous gel comprising at least a crosslinked hyaluronic acid and at least an uncrosslinked hyaluronic acid. The present invention also concerns an aqueous gel obtainable by said method compositions, a cosmetic and/or dermatological composition comprising said aqueous gels, and a kit comprising a pre-filled syringe comprising said aqueous gel or said composition. These gels and compositions are useful in particular for treating an alteration in the surface appearance of the skin and/or for augmenting and/or filling soft tissue.
Disclosed is a sterile and topical cosmetic composition including, in a physiologically acceptable medium, an efficient amount of crosslinked hyaluronic acid and an efficient amount of polyacrylate crosspolymer-6, Also disclosed is the use of said composition for reducing the signs of skin aging and/or to car the skin of a subject who has previously been subjected to one or more aesthetic and/or cosmetic intervention(s); and to a cosmetic process for caring the skin comprising at least the step of applying topically, on the skin surface(s) to be cared, an effective amount of said composition, to a subject who has previously been subjected to one or more aesthetic and/or cosmetic intervention(s).
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
A61K 8/04 - Cosmétiques ou préparations similaires pour la toilette caractérisés par une forme physique particulière Émulsions
Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt thereof; and an effective amount of at least mepivacaine or a salt thereof are provided. The hyaluronic acid optionally has an average molecular weight ranging from 50,000 to 10,000,000 Daltons, and may be crosslinked hyaluronic acids, non-crosslinked hyaluronic acids, or a combination, in some embodiments. The compositions and methods of the present invention are useful for treating and preventing the cutaneous signs of chronological aging and/or induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure, impaired surface appearance of the skin, impaired viscoelastic or biomechanical properties of the skin, and/or the long-lasting filling of volume defects of the skin.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
A61K 31/451 - Pipéridines non condensées, p.ex. pipérocaïne ayant un carbocycle lié directement à l'hétérocycle, p.ex glutéthimide, mépéridine, lopéramide, phencyclidine, piminodine
A sterile composition for intraepidermal, intradermal, and/or subcutaneous administration including an effective amount of hyaluronic acid or a salt thereof, the effective amount of hyaluronic acid or salt thereof ranging from 1 to 3 wt % of the overall weight of the sterile composition, mepivacaine or a salt thereof as a first anesthetic agent at a concentration ranging from 0.05 to 3 wt % of an overall weight of the sterile composition, and a balanced salt solution in which the sterile composition exhibits greater stability over time and/or during heat treatment resulting in sterilization in comparison to the same composition having lidocaine as the anesthetic agent instead of mepivacaine.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
Disclosed is a sterile and topical cosmetic composition including, in a physiologically acceptable medium, an efficient amount of crosslinked hyaluronic acid and an efficient amount of polyacrylate crosspolymer-6, Also disclosed is the use of said composition for reducing the signs of skin aging and/or to care the skin of a subject who has previously been subjected to one or raore aesthetic and/or cosmetic intervention(s); and to a cosmetic process for caring the skin comprising at least the step of applying topically, on the skin surface(s) to be cared, an effective amount of said composition, to a subject who has previously been subjected to one or more aesthetic and/or cosmetic intervention(s).
A61K 8/04 - Cosmétiques ou préparations similaires pour la toilette caractérisés par une forme physique particulière Émulsions
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
A61Q 19/00 - Préparations pour les soins de la peau
A61Q 19/08 - Préparations contre le vieillissement
18.
TOPICAL COMPOSITION COMPRISING CROSSLINKED HYALURONIC ACID AND A POLYACRYLATE COMPOUND
Disclosed is a sterile and topical cosmetic composition including, in a physiologically acceptable medium, an efficient amount of crosslinked hyaluronic acid and an efficient amount of polyacrylate crosspolymer-6, Also disclosed is the use of said composition for reducing the signs of skin aging and/or to care the skin of a subject who has previously been subjected to one or raore aesthetic and/or cosmetic intervention(s); and to a cosmetic process for caring the skin comprising at least the step of applying topically, on the skin surface(s) to be cared, an effective amount of said composition, to a subject who has previously been subjected to one or more aesthetic and/or cosmetic intervention(s).
A61Q 19/00 - Préparations pour les soins de la peau
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
A61Q 19/08 - Préparations contre le vieillissement
A61K 8/04 - Cosmétiques ou préparations similaires pour la toilette caractérisés par une forme physique particulière Émulsions
19.
Composition comprising hyaluronic acid and mepivacaine
Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt thereof; and an effective amount of at least mepivacaine or a salt thereof are provided. The hyaluronic acid optionally has an average molecular weight ranging from 50,000 to 10,000,000 Daltons, and may be crosslinked hyaluronic acids, non-crosslinked hyaluronic acids, or a combination, in some embodiments. The compositions and methods of the present invention are useful for treating and preventing the cutaneous signs of chronological aging and/or induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure, impaired surface appearance of the skin, impaired viscoelastic or biomechanical properties of the skin, and/or the long-lasting filling of volume defects of the skin.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
A61K 31/451 - Pipéridines non condensées, p.ex. pipérocaïne ayant un carbocycle lié directement à l'hétérocycle, p.ex glutéthimide, mépéridine, lopéramide, phencyclidine, piminodine
A61Q 19/08 - Préparations contre le vieillissement
A61K 31/445 - Pipéridines non condensées, p.ex. pipérocaïne
Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt thereof; and an effective amount of at least mepivacaine or a salt thereof are provided. The hyaluronic acid optionally has an average molecular weight ranging from 50,000 to 10,000,000 Daltons, and may be crosslinked hyaluronic acids, non-crosslinked hyaluronic acids, or a combination, in some embodiments. The compositions and methods of the present invention are useful for treating and preventing the cutaneous signs of chronological aging and/or induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure, impaired surface appearance of the skin, impaired viscoelastic or biomechanical properties of the skin, and/or the long-lasting filling of volume defects of the skin.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61Q 19/08 - Préparations contre le vieillissement
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
A61K 31/445 - Pipéridines non condensées, p.ex. pipérocaïne
A61K 31/451 - Pipéridines non condensées, p.ex. pipérocaïne ayant un carbocycle lié directement à l'hétérocycle, p.ex glutéthimide, mépéridine, lopéramide, phencyclidine, piminodine
Process for evaluating the mechanical performance of a filler gel, comprising the step consisting in subjecting a sample of this gel to oscillating mechanical stresses making it possible to determine the elastic modulus G′ and to deliver a score representative of the integration of G′ over the stress and/or the deformation strain within a stress and/or strain interval that includes values of the modulus G′ encountered beyond the linear viscoelasticity plateau.
G01N 11/00 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement
C08B 1/00 - Traitement préparatoire de la cellulose pour l'obtention de dérivés cellulosiques
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
A61K 8/04 - Cosmétiques ou préparations similaires pour la toilette caractérisés par une forme physique particulière Émulsions
Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt thereof; and an effective amount of at least mepivacaine or a salt thereof are provided. The hyaluronic acid optionally has an average molecular weight ranging from 50,000 to 10,000,000 Daltons, and may be crosslinked hyaluronic acids, non-crosslinked hyaluronic acids, or a combination, in some embodiments. The compositions and methods of the present invention are useful for treating and preventing the cutaneous signs of chronological aging and/or induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure, impaired surface appearance of the skin, impaired viscoelastic or biomechanical properties of the skin, and/or the long-lasting filling of volume defects of the skin.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/445 - Pipéridines non condensées, p.ex. pipérocaïne
A61K 31/451 - Pipéridines non condensées, p.ex. pipérocaïne ayant un carbocycle lié directement à l'hétérocycle, p.ex glutéthimide, mépéridine, lopéramide, phencyclidine, piminodine
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
A61L 27/12 - Matériaux contenant du phosphore, p.ex. apatite
The present invention relates to a process for preparing a crosslinked gel of at least one polysaccharide or a salt thereof, comprising at least the steps consisting in: a) providing a solution formed from an aqueous medium comprising at least said polysaccharide(s) or a salt thereof in a non-crosslinked form, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt; b) crosslinking the solution from step a) and, where appropriate; c) recovering said crosslinked gel formed.
Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt thereof; and an effective amount of at least mepivacaine or a salt thereof are provided. The hyaluronic acid optionally has an average molecular weight ranging from 50,000 to 10,000,000 Daltons, and may be crosslinked hyaluronic acids, non-crosslinked hyaluronic acids, or a combination, in some embodiments. The compositions and methods of the present invention are useful for treating and preventing the cutaneous signs of chronological aging and/or induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure, impaired surface appearance of the skin, impaired viscoelastic or biomechanical properties of the skin, and/or the long-lasting filling of volume defects of the skin.
Process for evaluating the mechanical performance of a filler gel, comprising the step consisting in subjecting a sample of this gel to oscillating mechanical stresses making it possible to determine the elastic modulus G' and to deliver a score representative of the integration of G' over the stress and/or the deformation strain within a stress and/or strain interval that includes values of the modulus G' encountered beyond the linear viscoelasticity plateau.
G01N 11/00 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement
A61K 8/00 - Cosmétiques ou préparations similaires pour la toilette
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
C08B 1/00 - Traitement préparatoire de la cellulose pour l'obtention de dérivés cellulosiques
The present invention relates to a process for preparing a crosslinked gel of at least one polysaccharide or a salt thereof, comprising at least the steps consisting in: a) providing a solution formed from an aqueous medium comprising at least said polysaccharide(s) or a salt thereof in a non-crosslinked form, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, l,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt; b) crosslinking the solution from step a) and, where appropriate; c) recovering said crosslinked gel formed.
Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt thereof; and an effective amount of at least mepivacaine or a salt thereof are provided. The hyaluronic acid optionally has an average molecular weight ranging from 50,000 to 10,000,000 Daltons, and may be crosslinked hyaluronic acids, non-crosslinked hyaluronic acids, or a combination, in some embodiments. The compositions and methods of the present invention are useful for treating and preventing the cutaneous signs of chronological aging and/or induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure, impaired surface appearance of the skin, impaired viscoelastic or biomechanical properties of the skin, and/or the long-lasting filling of volume defects of the skin.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/445 - Pipéridines non condensées, p.ex. pipérocaïne
A61K 31/451 - Pipéridines non condensées, p.ex. pipérocaïne ayant un carbocycle lié directement à l'hétérocycle, p.ex glutéthimide, mépéridine, lopéramide, phencyclidine, piminodine
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
A61L 27/12 - Matériaux contenant du phosphore, p.ex. apatite
The present invention relates to a crosslinked hyaluronic acid gel which derives from the crosslinking of hyaluronic acid or of a salt thereof in the presence of at least an effective amount of at least one endogenous polyamine as a crosslinking agent, said crosslinking being carried out under conditions favourable to the coupling of said hyaluronic acid and of said endogenous polyamine(s).
A method comprising at least the administering by injection to a patient inneed thereof of: (a) at least an efficient amount of hyaluronic acid or a salt thereof; and (b) at least an efficient amount of mepivacaine or a salt thereof as anesthetic agent, said mepivacaine being administered before or concurrently with the hyaluronic acid.
A61K 31/451 - Pipéridines non condensées, p.ex. pipérocaïne ayant un carbocycle lié directement à l'hétérocycle, p.ex glutéthimide, mépéridine, lopéramide, phencyclidine, piminodine
A61Q 90/00 - Cosmétiques ou préparations similaires pour la toilette, pour des utilisations spécifiques non prévues dans les autres groupes de la présente sous-classe
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61P 17/16 - Médicaments pour le traitement des troubles dermatologiques Émollients ou protecteurs, p.ex. contre les radiations
Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt thereof; and an effective amount of at least mepivacaine or a salt thereof are provided. The hyaluronic acid optionally has an average molecular weight ranging from 50,000 to 10,000,000 Daltons, and may be crosslinked hyaluronic acids, non-crosslinked hyaluronic acids, or a combination, in some embodiments. The compositions and methods of the present invention are useful for treating and preventing the cutaneous signs of chronological aging and/or induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure, impaired surface appearance of the skin, impaired viscoelastic or biomechanical properties of the skin, and/or the long-lasting filling of volume defects of the skin.
A61K 31/451 - Pipéridines non condensées, p.ex. pipérocaïne ayant un carbocycle lié directement à l'hétérocycle, p.ex glutéthimide, mépéridine, lopéramide, phencyclidine, piminodine
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61Q 19/08 - Préparations contre le vieillissement
31.
COMPOSITION COMPRISING HYALURONIC ACID AND MEPIVACAINE
A method comprising at least the administering by injection to a patient inneed thereof of: (a) at least an efficient amount of hyaluronic acid or a salt thereof; and (b) at least an efficient amount of mepivacaine or a salt thereof as anesthetic agent, said mepivacaine being administered before or concurrently with the hyaluronic acid.
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61P 17/16 - Médicaments pour le traitement des troubles dermatologiques Émollients ou protecteurs, p.ex. contre les radiations
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61Q 19/00 - Préparations pour les soins de la peau
A61Q 19/08 - Préparations contre le vieillissement
A61Q 90/00 - Cosmétiques ou préparations similaires pour la toilette, pour des utilisations spécifiques non prévues dans les autres groupes de la présente sous-classe
The present invention relates to a crosslinked hyaluronic acid gel which derives from the crosslinking of hyaluronic acid or of a salt thereof in the presence of at least an effective amount of at least one endogenous polyamine as a crosslinking agent, said crosslinking being carried out under conditions favourable to the coupling of said hyaluronic acid and of said endogenous polyamine(s).
The present invention relates to a crosslinked hyaluronic acid gel which derives from the crosslinking of hyaluronic acid or of a salt thereof in the presence of at least an effective amount of at least one endogenous polyamine as a crosslinking agent, said crosslinking being carried out under conditions favourable to the coupling of said hyaluronic acid and of said endogenous polyamine(s).
The subject of the present invention is a process for preparing a crosslinked gel of at least one polysaccharide or a salt thereof, comprising at least the steps consisting in: a)providing an aqueous gel comprising at least said polysaccharide(s) in a noncrosslinked form, combined with at least one crosslinking agent; b) crosslinking the mixture obtained at the end of step a) and, where appropriate; c)recovering said crosslinked gel formed, wherein the crosslinking step b) is carried out in a medium supplemented with at least one alkali halide salt present in a content of between 0.5%and 20% by weight relative to the total weight of the aqueous gel of step a).
The subject of the present invention is a process of preparing a crosslinked gel of at least one polysaccharide or one of its salts, including at least the steps consisting in: a) providing, at a temperature below 35° C., an aqueous gel including at least one polysaccharide in an uncrosslinked form together with at least one difunctional or multifunctional epoxy crosslinking agent; b) maintaining the mixture of step a) at a temperature below 35° C. for at least one hour; c) stimulating the crosslinking reaction of the mixture obtained after step b), and if need be; d) recovering said crosslinked gel formed.
A61Q 19/08 - Préparations contre le vieillissement
C08G 59/00 - Polycondensats contenant plusieurs groupes époxyde par molécule; Macromolécules obtenues par réaction de polycondensats polyépoxydés avec des composés monofonctionnels à bas poids moléculaire; Macromolécules obtenues par polymérisation de composés contenant plusieurs groupes époxyde par molécule en utilisant des agents de durcissement ou des catalyseurs qui réagissent avec les groupes époxyde
C08B 37/00 - Préparation des polysaccharides non prévus dans les groupes ; Leurs dérivés
C08B 37/08 - Chitine; Sulfate de chondroïtine; Acide hyaluronique; Leurs dérivés
The subject of the present invention is a process of preparing a crosslinked gel of at least one polysaccharide or one of its salts, comprising at least the steps consisting in: a) providing, at a temperature below 35oC, an aqueous gel comprising at least one polysaccharide in an uncross Linked form together with at least one difunctional or multifunctional epoxy crosslinking agent; b) maintaining the mixture of step a) at a temperature below 35°C for at least one hour; c) stimulating the crosslinking reaction of the mixture obtained after step b), and if need be: d) recovering said crosslinked gel formed.
The subject of the present invention is a process of preparing a crosslinked gel of at least one polysaccharide or one of its salts, comprising at least the steps consisting in: a) providing, at a temperature below 35oC, an aqueous gel comprising at least one polysaccharide in an uncross Linked form together with at least one difunctional or multifunctional epoxy crosslinking agent; b) maintaining the mixture of step a) at a temperature below 35°C for at least one hour; c) stimulating the crosslinking reaction of the mixture obtained after step b), and if need be: d) recovering said crosslinked gel formed.
The present invention relates to a process for preparing a crosslinked gel of at least one polysaccharide or a salt thereof, comprising at least the steps consisting in: a) providing at least one aqueous gel of said polysaccharide in a noncrosslinked form, b) bringing said aqueous gel into contact with an effective amount of at least one crosslinking agent, c) subjecting the mixture formed in step b) to conditions suitable for the crosslinking of said polysaccharide, and, if need be, d) recovering said crosslinked hydrogel, wherein said process comprises, prior to step c), at least one step e) consisting in circulating the aqueous gel of polysaccharide of step a) and/or the mixture of step b) through at least one extrusion device which has at least one filter with a porosity ranging from 2 to 100 microns and capable of retaining any particle with a diameter greater than 100 microns,
A process for preparing a crosslinked gel of at least one polymer or one of its salts, including a) providing an aqueous medium containing at least one polymer, b) forming a homogenous gel from the medium from step a), c) bringing the gel obtained in step b) into contact with an effective amount of at least one crosslinking agent; d) crosslinking the mixture formed in step c); and e) recovering the crosslinked hydrogel, wherein at least steps a) to d) are carried out within a hermetic cavity delimited at least partially by a deformable wall, the mixture present in the cavity being exposed, in step d), to conditions conducive to crosslinking.
Process for preparing a crosslinked gel of at least one polymer or one of its salts, comprising at least the steps that consist in: a) providing an aqueous medium containing at least one polymer, b) forming a homogeneous gel from the medium from step a), c) bringing the gel obtained in step b) into contact with an effective amount of at least one crosslinking agent; d) crosslinking said mixture formed in step c); and e) recovering said crosslinked hydrogel, wherein at least said steps a) to d) are carried out within a hermetic cavity delimited at least partially by a deformable wall, the mixture present in the cavity being ex-posed, in step d), to conditions conducive to crosslinking.
Process for preparing a crosslinked gel of at least one polymer or one of its salts, comprising at least the steps that consist in: a) providing an aqueous medium containing at least one polymer, b) forming a homogeneous gel from the medium from step a), c) bringing the gel obtained in step b) into contact with an effective amount of at least one crosslinking agent; d) crosslinking said mixture formed in step c); and e) recovering said crosslinked hydrogel, wherein at least said steps a) to d) are carried out within a hermetic cavity delimited at least partially by a deformable wall, the mixture present in the cavity being exposed, in step d), to conditions conducive to crosslinking.
