A thermal plasma can be generated using a pair of electrodes spaced apart from each other by a gap along a first direction. One or more reactants can be conveyed into and/or through at least a portion of the generated plasma. For example, the portion of the generated plasma can subject the reactant(s) to a temperature of at least 1000 K. As a result, the one or more reactants can undergo a thermochemical reaction that converts the one or more reactants into one or more products.
A rare earth doped single crystal diamond showing photoluminescence using off-resonant excitation at 853 nm and having a full width half maximum spectral linewidth at 1508 nm of less than 1.0 nm. There is also disclosed a method of producing rare earth doped single crystal diamond. A single crystal diamond is provided, and a rare earth metal is implanted into the single crystal diamond using ion implantation. The implanted single crystal diamond is then annealed at a pressure of at least 5 GPa and a temperature of at least 1600°C.
C30B 33/04 - Post-traitement des monocristaux ou des matériaux polycristallins homogènes de structure déterminée en utilisant des champs électriques ou magnétiques ou des rayonnements corpusculaires
C23C 14/06 - Revêtement par évaporation sous vide, pulvérisation cathodique ou implantation d'ions du matériau composant le revêtement caractérisé par le matériau de revêtement
The present invention is based, in part, on the identification of a minimal region of the SS18-SSX fusion oncoprotein that mediates a direct, high-affinity interaction between the mSWI/SNF complex and the nucleosome acidic patch, and methods and agents of modulating the interaction between the SS18-SSX fusion protein and H2A K119Ub-marked nucleosomes to treat synovial sarcoma.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
4.
MODULAR BIOSENSOR FOR RECEPTOR TYROSINE KINASE ACTIVITY
A modular biosensor (pYtags) for receptor tyrosine kinase activity may be provided, along with systems and techniques incorporating such biosensors. pYtags may include a cell surface receptor, such as a receptor tyrosine kinase (RTK), modified with a tyrosine activation motif that, when phosphorylated, recruits, e.g., a fluorescently labeled tandem SH2 domain with high specificity. Orthogonal pYtags can be used to monitor the dynamics of, e.g., EGFR and ErbB2 activity in the same cell, revealing distinct phases of activation for each RTK.
G01N 33/573 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour enzymes ou isoenzymes
G01N 33/554 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques le support étant une cellule ou un fragment de cellule biologique, p. ex. cellules de bactéries, de levure
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
5.
RHODOQUINONE MIMETICS AND METHODS OF MAKING AND USING THEREOF
Provided herein are rhodoquinone mimetics, including compounds defined by Formula I and Formula II. Also provided are methods, uses, and kits involving the disclosed compounds and pharmaceutical compositions thereof for treating and/or preventing a disease (e.g., a metabolic disorder (e.g., obesity, diabetes), a hypoxia related disease (e.g., a proliferative disease, inflammatory disease, neuromuscular disorder, neurodegenerative disorder, hypoxia, ischemia, oxidative stress, or a mitochondrial DNA related disorder), or a disease resulting from rhodoquinone depletion (e.g., a proliferative disease, inflammatory disease, neuromuscular disorder, metabolic disorder, or neurodegenerative disorder)) in a subject.
C07C 217/84 - Composés contenant des groupes amino et hydroxy éthérifiés liés au même squelette carboné ayant des groupes amino et des groupes hydroxy éthérifiés liés à des atomes de carbone de cycles aromatiques à six chaînons du même squelette carboné ayant des groupes amino et des groupes hydroxy éthérifiés liés à des atomes de carbone de cycles aromatiques à six chaînons non condensés du même cycle aromatique à six chaînons non condensé l'atome d'oxygène d'au moins un des groupes hydroxy éthérifiés étant lié de plus à un atome de carbone acyclique
C07C 225/28 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones le squelette carboné contenant des atomes de carbone de cycles quinoniques ayant des groupes amino liés à des atomes de carbone de cycles quinoniques ou de systèmes cycliques condensés contenant des cycles quinoniques de cycles quinoniques non condensés
A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
A61K 31/136 - Amines, p. ex. amantadine ayant des cycles aromatiques, p. ex. méthadone ayant le groupe amino lié directement au cycle aromatique, p. ex. benzène-amine
Disclosed is a method to control and manipulate floating water droplets. More particularly, disclosed are the self-assembly and pattern formation of electrically charged water droplets that are floating at an oil-gas interface. Also shown is that the assembly occurs because of electrostatic interactions between the drops. It is shown that the depth of the oil bath plays a significant role in the distance between the drops assembled at the interface. The relevance of the type of the boundary containing the entire system is highlighted by showing that even drops with a net zero electric charge can self-assemble under certain conditions. Furthermore, disclosed are ways to control the motion and the assembly of the drops at an interface.
The present disclosure provides systems, devices, and methods for using a user interface associated with musical composition. An example method may comprise outputting interface objects representing musical properties and establishing hierarchical relationships between the objects. A first interface object may visually represent a first musical property. A hierarchical relationship may be determined between the first object and a second object, indicating inheritance of the first property. Changes to the first property in the first object may update the second object.
G06F 16/683 - Recherche de données caractérisée par l’utilisation de métadonnées, p. ex. de métadonnées ne provenant pas du contenu ou de métadonnées générées manuellement utilisant des métadonnées provenant automatiquement du contenu
G10H 7/02 - Instruments dans lesquels les sons sont synthétisés à partir d'une mémoire de données, p. ex. orgues à calculateur dans lesquels les amplitudes d'une forme d'onde sonore en des points d'échantillonnage successifs sont stockées dans une ou plusieurs mémoires
G10H 7/08 - Instruments dans lesquels les sons sont synthétisés à partir d'une mémoire de données, p. ex. orgues à calculateur par le calcul de fonctions ou d'approximations polynomiales afin de déterminer l'amplitude en des points d'échantillonnage successifs d'une forme d'onde sonore
8.
SUBSTITUTED CUBANES AND METHODS OF MAKING THE SAME
C07C 51/29 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par oxydation avec des composés contenant des atomes d'halogène, ceux-ci pouvant être formés in situ
C07C 61/125 - Composés polycycliques saturés comportant un groupe carboxyle lié à un système cyclique condensé
C07C 67/10 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques avec des groupes ester ou avec une liaison carbone-halogène
C07C 69/753 - Esters d'acides carboxyliques dont un groupe carboxyle est lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons d'acides polycycliques
A61K 31/166 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome de carbone d'un groupe carboxamide lié directement au cycle aromatique, p. ex. procaïnamide, procarbazine, métoclopramide, labétalol
A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
An ink may be provided that includes a two-dimensional WS2 nanosheet and an organic solvent, such as water, and may be free of protective molecules and surfactants. Circuits may be provided that include this ink disposed onto a surface of a substrate (such as a flexible substrate) in various patterns, including, e.g., a superconducting qubit. The ink may be formed by sonicating, then centrifuging at a first speed, a sulfuric acid-KxWS2 solution, where x=0.3˜0.7, removing any supernatant from the centrifuged first suspension and replacing with water and sonicating the resulting WS2-water suspension, then centrifuging the result at a speed slower than the first speed, and using an upper portion of the resulting suspension.
H05K 1/09 - Emploi de matériaux pour réaliser le parcours métallique
H05K 3/12 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché utilisant la technique de l'impression pour appliquer le matériau conducteur
11.
METHODS, DEVICES, AND SYSTEMS FOR MULTIPHASE COUPLED INDUCTORS
Tile present disclosure relates to systems and methods for multiphase coupled inductors. The multiphase coupled inductor includes a magnetic ladder core assembly. The magnetic ladder core assembly includes: a first row of at least one rung, wherein an electrically conductive winding is wound around each rung of the at least one rung, forming a first row of electrical windings along a first direction; a second row of at least one rung, wherein an electrically conductive winding is wound around each rung of the at least one rung, forming a second row of electrical windings along the first direction; and a middle rail having a width along a second direction normal to the first direction, separating the first and the second row of electrical windings.
H02M 3/158 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu sans transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs avec commande automatique de la tension ou du courant de sortie, p. ex. régulateurs à commutation comprenant plusieurs dispositifs à semi-conducteurs comme dispositifs de commande finale pour une charge unique
H02M 1/00 - Détails d'appareils pour transformation
Disclosed is a method for forming selenoneine or analogs thereof. The method may include phosphorylating sodium selenide to a selenophosphate, using adenosine triphosphate (ATP) and at least a first protein, generating a selenosugar by converting the selenophosphate using at least a second protein in the presence of a common sugar donor, and forming selenoneine or an analog thereof by combining the selenosugar with N,N,N-trimethyl-L-histidine or analogs thereof using at least a third protein. The method may include combining SenA, SenB, and SenC in an aqueous buffer at neutral pH and ambient temperature, and allowing SenA, SenB, and SenC to form selenoneine or an analog thereof in the presence of ATP, a common sugar donor, and sodium selenide.
C12P 17/10 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'azote comme unique hétéro-atome du cycle
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
San Diego State University Research Foundation (USA)
Inventeur(s)
Kleiner, Ralph
Wang, Danyang
Purse, Byron
Shalamberidze, Ana
Abrégé
Disclosed is a platform for fluorescence imaging of bulk RNA dynamics in living cells. The platform utilizes a technique including exposing a plurality of live cells configured to overexpress a WT or mutant ribonucleoside kinase UCK2 under control of an inducible promoter, a constitutively active promoter, or both, to a first quantity of a fluorescent nucleoside (such as fluorescent bicyclic and tricyclic cytidine analogues) for a first period of time.
Antenna arrays, systems and methods using an algorithm-based array synthesis approach of designing and manufacturing an antenna array with non-uniform element distribution which fundamentally enables low side lobe beamforming capability over desired broadband/multiband frequency range across large scanning angles.
H01Q 5/20 - Dispositions pour faire fonctionner simultanément des antennes sur plusieurs gammes d'ondes, p. ex. dispositions bibandes ou multibandes caractérisées par les gammes d'ondes exploitées
H01Q 3/38 - Dispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier la phase relative ou l’amplitude relative et l’énergie d’excitation entre plusieurs éléments rayonnants actifsDispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier la distribution de l’énergie à travers une ouverture rayonnante faisant varier la phase par des moyens électriques avec des déphaseurs variables les déphaseurs étant numériques
H01Q 9/28 - Éléments coniques, cylindriques, en cage, en ruban, en treillis ou éléments analogues ayant une surface de rayonnement étendueÉléments comportant deux surfaces coniques ayant le même axe et opposées par leurs sommets et alimentés par des lignes de transmission à deux conducteurs
15.
Systems and Methods for Analyzing Genetic Data for Assessment of Gene Regulatory Activity
The Board of Regents of The University of Texas System (USA)
Inventeur(s)
Troyanskaya, Olga G.
Chen, Kathleen
Zhou, Jian
Abrégé
Processes that determine transcriptional regulation from genetic sequence data are described. Generally, computational models are trained to predict transcriptional regulatory effects, which can be used in several downstream applications. Various methods further develop research tools, develop and perform diagnostics, and treat individuals based on identified variants.
Described herein, are compositions and methods for preserving human milk, preventing rancidity of human milk, extending shelf life of human milk, and maintaining the nutritional properties of human milk. Specifically, the present disclosure provides, among other things, devices for storing preserved human milk and methods and compositions for preserving the same.
A processing unit leverages a decode stage's pool of instructions, thereby expanding available instruction choices and eliminating the need for expensive OoO techniques to identify reordering opportunities. The processing unit introduces instruction reordering by presenting an alternative instruction to the warp scheduler through the existing interface rather than offering the oldest instruction in each warp. The result is a simple and efficient OoO engine that operates predominantly in the processing unit's front end.
Disclosed are techniques for training a graph language model (GEM). The techniques generally include training the GEM on a training corpus, expanding a current training knowledge graph into an expanded knowledge graph by distilling semantic information from the training corpus using neural inversion. The knowledge graph is only expanded when there is new data, and if convergence has not been reached, the method may include updating the training corpus by injecting the expanded knowledge graph into the training corpus, thereby making the expanded knowledge graph the current training knowledge graph. The training, expanding, and updating steps are repeated until convergence. The training corpus may be formed by parsing a dataset into chain graphs, where syntactic language information is represented as a chain sequence of one or more root nodes, and where semantic information from the seed knowledge graph is added as leaf nodes around each root node.
A method for quantum error correction includes: trapping and/or manipulating an array of qubits that include encoded neutral atoms or ions and forms a computational space; encoding the array of qubits to a state characterized in that an error during at least one of an idling, gate, or other operation results in a respective qubit transition to a disjointed state where that error can be detected without disturbing the qubits remaining in the computational space; performing a syndrome measurement of a quantum error correcting code; identifying the presence and location of an error by detecting the corresponding neutral atom or ion has left the computational space after performing the operation; identifying a logical error in the quantum error correcting code associated with a loss of qubit information based on the identified error location and results of the syndrome measurement; and adjusting subsequent computational steps based on the identified logical error.
G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p. ex. codes de surface ou distillation d’état magique
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
20.
MOSQUITO ATTRACTANT COMPOSITIONS THAT MIMIC HUMAN ODOR IN THE MOSQUITO BRAIN
Mosquito attractant compositions that mimic the neural activity evoked by real human odor in the mosquito brain. The attractant compositions comprise 1-hexanol and linear long chain aldehydes that mimic human attractant odors and that differentiate humans from other animals. Methods for controlling malaria and dengue virus transmission as well as other diseases that are transmitted using mosquitos as vectors are included as are general methods and devices for attracting, killing, and controlling populations of mosquitos.
A01N 25/02 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles contenant des liquides comme supports, diluants ou solvants
A01N 35/02 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant deux liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. un radical aldéhyde contenant des groupes aldéhyde ou cétone, ou leurs thio-analogues, liés aliphatiquementLeurs dérivés, p. ex. acétals
Use of high frequency waves, such a millimeter waves, in many circumstances is prevented due to their inability to diffract around common obstacles. Disclosed herein is a system and method for transforming an incident high frequency wave. The system includes meta-atom pairs that define a surface. The meta-atom pairs generate an electro-magnetic response by interacting with an incident wave. This electro-magnetic response can be modulated by applying voltage to the meta-atom pairs. The electro-magnetic response transforms the incident wave into an emitted wave based on its controlled properties. The system and method are able to, by changing the voltage applied, steer the emitted wave a full 360 degrees as wells as transmit it through the surface without significant power loss. Embodiments enable the transmission through or around many obstacles that would normally interfere with high frequency waves.
H04W 72/542 - Critères d’affectation ou de planification des ressources sans fil sur la base de critères de qualité en utilisant la qualité mesurée ou perçue
H04B 17/13 - SurveillanceTests d’émetteurs pour l’étalonnage d’amplificateurs de puissance, p. ex. de gain ou de non-linéarité
H04B 17/391 - Modélisation du canal de propagation
H04W 72/044 - Affectation de ressources sans fil sur la base du type de ressources affectées
H04W 72/0453 - Ressources du domaine fréquentiel, p. ex. porteuses dans des AMDF [FDMA]
22.
SYSTEMS AND METHODS FOR SINGLE-CELL OMICS ANALYSIS WITH DATA-DRIVEN BATCH INFERENCE
Systems and methods for batch correcting single-cell abundance data obtain a measurement value of each feature in a plurality of features originating from each cell in a plurality of cells. The cells collectively originate from a plurality of samples. Feature measurements for each cell are used to cluster the cells into clusters. Cluster assignments of each cell and an identity of a sample in the plurality of samples from which each cell originated are used to compute sample-level local inverse Simpson index (LISI) scores penalized by a measure of importance of cells in each sample. Scores are scaled and ordered before application of a Dixon's Q-test groups them into one or more groups. For each respective group, a common batch assignment is applied to each of the samples in the respective group.
A flat nanophotonic computational camera, which employs an array of skewed lenslets (meta-optics) and a learned reconstruction approach is disclosed herein. The optical array is embedded on a metasurface that with a height of approximately one micron, is flat and sits on the sensor cover glass at approximately 2.5 mm focal distance from the sensor. A differentiable optimization method continuously samples over the visible spectrum and factorizes the optical modulation for different incident fields into individual lenses. A megapizel image is reconstructed from a flat imager with a learned probabilistic reconstruction method that employs a generative diffusion model to sample an implicit prior. A method for acquiring paired captured training data in varying illumination conditions is proposed. The proposed flat camera design is assessed in simulation and with an experimental prototype, validating that the method is capable of recovering images from diverse scenes in broadband with a single nanophotonic layer.
Disclosed is a method for quantitative detection of a small, aberrant viral nucleic acid. The method includes combining a detection mixture with a sample, and allowing a reaction with the test mixture to begin. The sample includes an RNA sample. The detection mixture includes a Cas13 enzyme, a reporter, a sequence-specific CRISPR RNA (crRNA), and a buffer. The method includes determining a quantitative value representative of the reporter in the test mixture, where the quantitative value is a measure of an amount of target RNA present in the RNA sample.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
Disclosed is a technique for improving the throughput of a neural network, using multiplexing and demultiplexing of information. Specifically, the multiplexing may include receiving a plurality of inputs, generating transformed inputs by performing, via a multiplexing layer, a transformation to each input of the plurality of inputs, and combining the transformed inputs into a single compact representation of the plurality of inputs. The demultiplexing may include receiving an output from a neural network, generating a plurality of values by converting, via a demultiplexing layer, the output back into independent representations, and producing predictions for each input based on the plurality of values. Further improvements may be seen when pretraining of the neural network and/or high-throughput transformers are incorporated.
The present disclosure provides a rapid, facile, economical, and highly scalable method for producing selenoneine. The method involves SenA, hercynine, a selenosugar, and optionally a reductant, and a single, high-yielding enzymatic step in, e.g, aneutral-pH aqueous buffer and at ambient temperature. It can achieve yields of around 5 grams selenoneine per liter reaction with approximate costs of $100 per gram selenoneine.
C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
C12P 17/10 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'azote comme unique hétéro-atome du cycle
B01D 15/08 - Adsorption sélective, p. ex. chromatographie
Disclosed herein are compounds of Structural Formula I. Compounds of Structural Formula I inhibit aldehyde dehydrogenase isoform 1a3 (ALDH1a3) and are useful for treating cancer, for example, metastatic or chemoresistant cancer, such as metastatic cancer resistant to chemotherapy. Also disclosed herein are compositions comprising compounds of Structural Formula I and uses of compounds of Structural Formula I for treating cancer, for example, metastatic or chemoresistant cancer.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
28.
HIGH-THROUGHPUT METHODS TO IDENTIFY AND CLASSIFY MODULATORS OF NUCLEOLAR MORPHOLOGY AND FUNCTION
Disclosed is a method coupling automated microscopy imaging with a deep neural network and computational modeling to classify distinct drug-induced nucleolar morphology changes with high accuracy and link them to nucleolar dysfunction. As such, this method can enable high-throughput characterization of nucleolar and other condensate phase behavior changes in chemical or genetic screens, directly linking condensate morphology changes to its physical mechanism of action for the first time.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A system for determining the ripeness of a food product (such as a fruit or vegetable) may include a metamaterials-based sticker configured to be coupled to an outer surface of the food product. The sticker may include micron-scale metal resonators coupled to a base, and may be configured to resonate at a sub-terahertz (THz) frequency. The system may include a handheld device, which may include a receiver configured to receive a reflection spectrum from the sticker after the sticker has been excited by electromagnetic radiation. The receiver may be configured to detect one or more wavelengths having frequencies of around 100 GHz - 170 GHz and 210 - 250 GHz. The system may include processing unit(s) configured to, collectively, perform various steps, including determining a resonant frequency, a dielectric property, a refractive index, or a value representative of the ripeness of the food product based on a reflection spectra.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G02B 1/00 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques
30.
METHODS TO CHARACTERIZE THE COMPOSITIONAL AND FUNCTIONAL HISTORIES OF CELLULAR PROTEINS AND ASSOCIATED MACROMOLECULAR COMPLEXES IN SPACE AND TIME
Disclosed is a method for characterizing compositional and functional histories of cellular proteins and their associated molecular complexes in space and time. The method may include forming fusion proteins by fusing a universal genetic tag to each of a plurality of endogenous proteins. The fusion proteins may be conditionally labelled with a first ligand. The first ligand may be a ligand with a developed immunopurification capability and a known imaging capability. The method may include expressing the fusion proteins and performing at least one analysis. The analyses may include (i) tracking the plurality of endogenous proteins and any associated macromolecular complexes; (ii) determining composition and function of the plurality of endogenous proteins and/or any associated macromolecular complexes; and/or (iii) removing a ligand and performing a pulse-chase analysis.
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
Disclosed are techniques for enhanced nucleic acid detection using blocked or partially blocked crRNAs or target RNAs, and a composition of matter (detection reactions consisting of occluded crRNAs or target RNAs). Here, the mechanism of Cas 13 protein activation in response to RNA structure perturbations was systematically probed using a massively multiplexed screen. It was found that there are two distinct sequence-independent modes by which secondary structure affects Cas13 activity: structure in the protospacer region competes with the crRNA and can be disrupted via a strand-displacement mechanism, while structure in the region 3′ to the protospacer has an allosteric inhibitory effect. The kinetic nature of the strand displacement process was leveraged to improve Cas13-based RNA detection and enhance mismatch discrimination by up to 50-fold, enabling sequence-agnostic mutation identification at low (<1%) allele frequencies.
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
C12Q 1/683 - Tests d’hybridation pour la détection de mutation ou de polymorphisme faisant intervenir des enzymes de restriction, p. ex. polymorphisme de longueur de fragment de resctriction
C12Q 1/6832 - Amélioration de la réaction d’hybridation
32.
INVERSE SYSTEM DESIGN FOR CONSTRAINED MULTI-OBJECTIVE OPTIMIZATION
A design methodology and tool called INFORM are provided that use a two-phase approach for sample-efficient constrained multi-objective optimization of real-world nonlinear systems. In the first optional phase, one may modify a genetic algorithm (GA) to make the design process sample-efficient, and may inject candidate solutions into the GA population using inverse design methods. The inverse design techniques may be based on (i) a neural network verifier, (ii) a neural network, and (iii) a Gaussian mixture model. The candidate solutions for the next generation are thus a mix of those generated using crossover/mutation and solutions generated using inverse design. At the end of the first phase, one obtains a set of nondominated solutions. In the second phase, one chooses one or more solution(s) from the non-dominated solutions or another reference solution to further improve the objective function values using inverse design methods.
G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
G06F 111/06 - Optimisation multi-objectif, p. ex. optimisation de Pareto utilisant le recuit simulé, les algorithmes de colonies de fourmis ou les algorithmes génétiques
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Association services, namely, promoting the interests of alumni; arranging, organizing, conducting, and hosting alumni events for business development, business networking, and professional networking purposes; promoting special events of university and alumni groups; charitable services, namely, organizing and conducting volunteer programs and community service projects; administration of a program for alumni to interview university applicants Arranging, organizing, conducting and hosting social entertainment events; organizing and arranging of seminars, discussions, and lectures in the fields of general interest, education, music, art, science, literature, government, social justice, leadership development, sports, and academics; educational services, namely, providing educational speakers and lecturers; providing an interactive website featuring information related to educational, entertainment, athletic and social events for alumni of an educational institution; providing online newsletters featuring articles and information regarding alumni news, alumni achievement, career opportunities, and networking events
A process for making liquid fuels, especially diesel fuel, from primary alcohols. The process involves subjecting a feedstock comprising primary alcohols to Guerbet coupling to yield a first intermediate mix; subjecting the first intermediate mix to hydrogenolysis to yield a second intermediate mix; and subjecting the second intermediate mix to etherification to yield a liquid fuel suitable for use in internal combustion engines.
F02D 19/06 - Commande des moteurs caractérisés par l'emploi de combustible non liquide, de combustibles multiples ou de substances non combustibles ajoutées au mélange carburant particulière aux moteurs fonctionnant avec des combustibles multiples, p. ex. alternativement du fuel léger et du fuel lourd, et autres que les moteurs indifférents au combustible utilisé
36.
METHOD FOR CONVERTING FARNESYL PYROPHOSPHATE SYNTHASE INTO A GERANYL PYROPHOSPHATE SYNTHASE
Disclosed are techniques for monoterpenes biosynthesis in engineered microorganisms having a mevalonate pathway, where the microorganisms express an engineered enzyme. The engineered enzyme may include one or more peptides that are selected to alter the active site pocket volume of the engineered enzyme as compared to a wild-type farnesyl pyrophosphate synthase. The engineered enzyme may include a first peptide (such as a linker peptide) fused to a C-terminus of a farnesyl pyrophosphate synthase. Optionally, a second peptide (such as a Myc-tag or a HA-tag) be fused to the first peptide. The method may include exposing the engineered microorganism to a carbon source (such a glucose). The method may include allowing the engineered microorganism to generate (i) a first product from the mevalonate pathway and (ii) the engineered enzyme. The method may include forming a monoterpene by allowing the first product and the engineered enzyme to interact.
C12P 5/02 - Préparation des hydrocarbures acycliques
C07K 14/395 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de champignons provenant de levures provenant de Saccharomyces
Disclosed are a method and system for thermal stabilization of pharmaceutical formulations containing proteins and monoclonal antibodies. The disclosed method of Rapid Room Temperature Aerosol Dehydration (RTAD) provides a scalable system for continuous dehydration of liquid pharmaceutical and biopharmaceutical formulations that provides thermal stabilization of biological drugs by converting liquid drugs into powder form, enabling their transportation, storage and handling at room temperature. The disclosed process can generate sprays/aerosols with droplets that are lOOx smaller (0.2-20 pm ) than existing spray drying technologies and perform dehydration without applying heat, which mitigates the risk of damage of thermolabile biologicals and provides a significant reduction in energy requirements. The technology has demonstrated superiority of tire system over traditional spray drying and freeze drying with respect to energy consumption, biological activity, scalability, powder dissolution, reduced protein aggregation, particle size and size uniformity, and high- quality of produced inhalable and reconstitutable biologic formulations.
B05B 7/24 - Appareillages de pulvérisation pour débiter des liquides ou d'autres matériaux fluides provenant de plusieurs sources, p. ex. un liquide et de l'air, une poudre et un gaz avec des moyens, p. ex. un récipient, pour alimenter en liquide ou autre matériau fluide un dispositif de décharge
B05B 9/04 - Appareillages de pulvérisation pour débiter des liquides ou d'autres matériaux fluides, n'impliquant pas de mélange avec des gaz ou des vapeurs caractérisés par les moyens d'alimentation en liquide ou en autre matériau fluide comportant un réservoir sous pression ou compressibleAppareillages de pulvérisation pour débiter des liquides ou d'autres matériaux fluides, n'impliquant pas de mélange avec des gaz ou des vapeurs caractérisés par les moyens d'alimentation en liquide ou en autre matériau fluide comportant une pompe
F26B 3/12 - Procédés de séchage d'un matériau solide ou d'objets impliquant l'utilisation de chaleur par convection, c.-à-d. la chaleur étant transférée d'une source de chaleur au matériau ou aux objets à sécher par un gaz ou par une vapeur, p. ex. l'air le gaz ou la vapeur entraînant le matériau ou les objets à sécher sous forme d'une pulvérisation
B05B 7/16 - Appareillages de pulvérisation pour débiter des liquides ou d'autres matériaux fluides provenant de plusieurs sources, p. ex. un liquide et de l'air, une poudre et un gaz comportant des moyens pour chauffer la matière à projeter
B01D 1/18 - Évaporation par pulvérisation pour obtenir des solides secs
F26B 21/00 - Dispositions pour l'alimentation ou le réglage de l'air ou des gaz pour le séchage d'un matériau solide ou d'objets
A process for making liquid fuels, especially diesel fuel, from primary alcohols. The process involves subjecting a feedstock comprising primary alcohols to Guerbet coupling to yield a first intermediate mix; subjecting the first intermediate mix to hydrogenolysis to yield a second intermediate mix; and subjecting the second intermediate mix to etherification to yield a liquid fuel suitable for use in internal combustion engines.
C10L 1/02 - Combustibles carbonés liquides à base essentielle de composants formés uniquement de carbone, d'hydrogène et d'oxygène
C07C 2/06 - Préparation d'hydrocarbures à partir d'hydrocarbures contenant un plus petit nombre d'atomes de carbone par addition d'hydrocarbures non saturés entre eux par oligomérisation d'hydrocarbures non saturés bien définis, sans formation de cycle d'alcènes, c.-à-d. d'hydrocarbures acycliques ne comportant qu'une seule liaison double carbone-carbone
C07C 37/16 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone d'un cycle aromatique à six chaînons par des réactions augmentant le nombre d'atomes de carbone par condensation impliquant des groupes hydroxyle de phénols ou d'alcools, ou leurs groupes éther ou ester minéral
C07C 41/09 - Préparation d'éthers par déshydratation de composés contenant des groupes hydroxyle
Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.
A synthetic triterpene composition such as squalene and methods for producing the composition by novel chemical synthesis routes is claimed. The squalene produced by the synthetic methods covered in this invention formulation is of high purity suitable for use in making vaccine adjuvants, antioxidant formulations, and drug delivery agents.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
41.
SYSTEMS AND METHODS FOR PREDICTING HIGH RESOLUTION CELL-TYPE-SPECIFIC GENE TRANSCRIPTION AND APPLICATIONS THEREOF
Systems and methods for predicting cell-type-specific gene expression from genetic sequence are described. A computational framework can comprise a computational model for predicting epigenetic regulatory markers using genetic sequence as input. A computational framework can additionally, or alternatively, comprise a computational model for predicting cell-type-specific gene expression utilizing epigenetic regulatory markers spaced along sequence of genes. The computational model for predicting cell-type-specific gene expression can be trained with single-cell genetic expression profiles, such as scRNA-seq or snRNA-seq. The computational framework can be utilized to assess polymorphic sequences, such as polymorphisms related to medical disorders. Various methods further develop research tools, perform diagnostics, and treat individuals based on cell-type-specific gene expression levels, which can be further based on differential gene expression patterns among polymorphic sequences.
Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches.
According to various embodiments, a machine-learning based system for mental health disorder identification and monitoring is disclosed. The system includes one or more processors configured to interact with a plurality of wearable medical sensors (WMSs). The processors are configured to receive physiological data from the WMSs. The processors are further configured to train at least one neural network based on raw physiological data augmented with synthetic data and subjected to a grow-and-prune paradigm to generate at least one mental health disorder inference model. The processors are also configured to output a mental health disorder-based decision by inputting the received physiological data into the generated mental health disorder inference model.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
44.
MAGNETIC ORBITAL ANGULAR MOMENTUM BEAM ACCELERATION
A magnetic orbital angular momentum beam accelerator will accelerate charged particles, electrons or ions, from rest in zero or low magnetic field into a high magnetic field regions with high kinetic energies in the form of magnetic orbital angular momentum. For example, a beam injector that accelerates electrons or ions into 1T magnetic fields with tens of keV kinetic energies transverse to the magnetic fields can be used to heat magnetically confined plasmas, to inject an initial energetic plasma component with high magnetic orbital angular momentum and to produce highly transverse particle momenta to the magnetic field for electron or ion beam lithography.
Compositions of matter and methods for using the composition of matter may be provided. The method may include providing a virus-like particle (VLP) comprising C. elegans retrotransposon 1 (Cer1) and a heterologous RNA-based agent to an organism and allowing the organism to transfer the heterologous RNA-based agent to a tissue within the organism.
Cas-cleavable reporter systems, CRISPR-Cas systems thereof, and methods of use thereof in CRISPR-Cas based diagnostics. Cas-cleavable reporter systems may generate a luminescent, fluorescent, or other detectable signal upon Cas-collateral cleavage of one or more reporter system components. CRISPR-Cas systems may comprise a Cas protein having collateral cleavage activity, guide molecules, and the Cas-cleavable reporter system. Cas-cleavable reporter systems may be a split luciferase reporter system, at least one element of which is bound to beads. For multiplexing, CRISPR-Cas systems may comprise a Cas-cleavable quenched reporter system, optionally a Cas-cleavable quenched fluorescent reporter system, a Cas protein having collateral cleavage activity, and target-specific guide molecules attached to color-coded beads. CRISPR-Cas systems may further comprise amplification reagents. Methods may apply said CRISPR-Cas systems to flow cell, well-plate, or other devices, and may measure detectable signals by microscopic, plate reader, or other methods.
Disclosed is a technique that enables structural reinforcement and thermal stabilization of the conductor winding in a superconducting coil configuration, and superconducting coils produced via the technique. The superconducting coils generally include coil windings of superconducting materials defining an electrically conductive channel having an inlet and an outlet, where the coil windings are either (i) helically wound around a curve around a central axis or (b) wound in helical layers around a curve around a central axis. One or more of the coil windings are operably coupled to at least one co-wound reinforcement layer, where the at co-wound reinforcement layer(s) are positioned between at least two adjacent superconducting coil windings or layers of superconducting coil windings. The method can significantly improve the packing factor in a coil winding while simplifying quench protection, permitting the construction of all-metal high field magnets with large bore and high magnetic field.
H01F 6/06 - Bobines, p. ex. dispositions pour l'enroulement, l'isolation, les enveloppes ou les bornes des bobines
G01R 33/3815 - Systèmes pour produire, homogénéiser ou stabiliser le champ magnétique directeur ou le champ magnétique à gradient utilisant des électro-aimants avec des bobines supraconductrices, p. ex. leurs alimentations
H01F 6/02 - Étouffement de la supraconductivitéDispositions pour la protection lors de la phase de transition vers l'état de conductivité normale
H01F 41/04 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateursAppareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques pour la fabrication de noyaux, bobines ou aimants pour la fabrication de bobines
48.
OPTOGENETIC CIRCUITS FOR CONTROLLING CHEMICAL AND PROTEIN PRODUCTION IN ESCHERICHIA COLI
Disclosed herein are optogenetic circuits for the bacterium Escherichia coli that induce gene expression in darkness and repress it under blue light. Applying them to metabolic engineering improves chemical production compared to chemically induced controls in light-controlled fermentations. More particularly, these circuits can be used to control protein production with light. The system and method use light as a suitable alternative to chemical induction for microbial production of chemicals and proteins.
Disclosed are methods and a pharmaceutical composition for the prevention and treatment of fibrosis by the inhibition of fibronectin matrix assembly, as well as insights into the molecular mechanism by which cell-mediated assembly of fibronectin (FN) matrix contributes to extracellular matrix (ECM) accumulation. Peptides S2, S3, S20, and variants thereof may be utilized, either alone or fused to one or more proteins. In one aspect, a construct comprising a first protein fused to a first end of a peptide and a second protein fused to a second end of the peptide may be used, where the peptide has at least 80% sequence identity to S2, S3, or S20. The peptide may then be allowed to interact with fibronectin.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
in situin situ position detection, thickness and refractive index measurement, and/or focus control, are provided. The systems may include a first laser emitting device, a first lens, a first beam splitter and a second lens respectively forming an optical path. The second lens, the first beam splitter, a third lens, and an image detection and processing module (that includes a sensor, such as a photodiode) may form an optical return path. The second lens may be configured to continuously oscillate, as a function of time, a focal position of a laser from the first laser emitting device. The image detection and processing module may be configured to receive a reflected beam, send information related to the received beam to processing units(s), which may be configured to receive the information and determine one or more surface positions based on a temporal response of the information.
G01B 11/06 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur pour mesurer l'épaisseur
G01N 21/41 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique
Methods for co-designing transformer-accelerator pairs are provided. The methods may include using a transformer embedding to generate a computational graph and a transformer model. The methods may include running the computational graph through a surrogate model and outputting accuracy data of the surrogate model. The methods may include using an accelerator embedding and the transformer model to simulate training and inference tasks and outputting hardware performance data of the transformer model. The methods may include sending the hardware performance data (such as latency, energy leakage, dynamic energy, and chip area, which may be optimizable performance parameters) and model accuracy data to a co-design optimizer. The methods may include generating an output transformer-accelerator or a transformer-edge-device pair from the co-design optimizer. The transformer model and accelerator embedding may be the output transformer-accelerator or a transformer-edge-device pair.
Block copolymer-stabilized nanoparticles (50 nm - 1000 nm in size) of oligonucleotides with a polyethylene glycol (PEG) steric stabilizing layer are provided. Such nanoparticles may be formed using stabilizing blocks of PEG with molecular weights of 1000-5000 Dalton molecular weight, and hydrophobic anchoring blocks of a degradable polylactide and/or degradable lactide-co-glycolide polymer with molecular weights of 1000-20,000 Dalton molecular weight. The anchoring blocks may be, e.g., a polycaprolactone polymer, a polylactic acid polymer, and/or a copolymer of a lactide-co-glycolide polymer. Such nanoparticles are preferably configured to be internalized into cells and transfect cells at least as effectively as a lipid nanoparticle formulated with 1500 Dalton molecular weight PEG and Dimyristoyl glycerol (DMG) anchoring lipids.
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
B82B 3/00 - Fabrication ou traitement des nanostructures par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles
53.
THREOGLUCINS AS POTENT-ANTIBACTERIAL AGENTS AGAINST STREPTOCOCCUS SUIS
Compositions are provided that can be used to, e.g., treat or prevent infections caused by Streptococcus suis. The compositions may include one or more threoglucins in a carrier, at a total concentration of threoglucins being at least 1 μM. The at least one threoglucin may include one or more of threoglucins A-R. Such threoglucins may be produced by, e.g., growing a culture of Streptococcus suis in the presence of niacin, nicotinamide, and/or anabasine.
Disclosed is a method to 3D print materials with defined bacterial communities into controlled, complex 3D structures, and compositions. The technique includes first providing an ink composition that includes a pre-polymer composition and a microorganism, where the pre-polymer composition includes a polymerizable monomer, a cross-linking agent, the photoinitiator, and a solvent. The technique also includes 3D printing a pattern in a hydrogel support matrix using the ink composition where the hydrogel support matrix is in a container. The technique may also include forming a 3D printed engineered living material by curing the 3D printed pattern.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B29C 64/40 - Structures de support des objets en 3D pendant la fabrication, lesdites structures devant être sacrifiées après réalisation de la fabrication
B29K 33/00 - Utilisation de polymères d'acides non saturés ou de leurs dérivés comme matière de moulage
B29K 105/00 - Présentation, forme ou état de la matière moulée
Provided are polynucleotides comprising a transcriptional control element comprising a promoter sequence having at least 80% sequence identity to SEQ ID NO: 1. SEQ ID NO:2. SEQ ID NO:3 or SEQ ID NO:4 and a cell- or tissue-specific enhancer element. Also provided are compositions (e.g., vectors, viruses, host cells, and pharmaceutical compositions) comprising said polynucleotides, methods that are useful for expressing a target gene in a host cell, and methods that are useful for expressing a target gene in a subject in need thereof.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
Systems and methods for fibrous material manufacturing are provided. The methods include dispensing a first stream of a solution (that includes a crosslinkable material) from first nozzle(s) into a bath containing a liquid (that includes a first material). The first nozzle(s) are submerged in the liquid. The methods include dispensing a second stream from second nozzle(s) also submerged in the liquid. The second stream(s) are configured to elongate and thin the first stream(s). The second stream contain a liquid. The liquid includes a second material, which may be the same, or may be different, form the first material. The methods include forming a fibrous material by crosslinking the crosslinkable material in the first stream (e.g., using a light source to cross-link a photo-crosslinkable material in the stream).
D01F 1/08 - Addition de substances à la solution de filage ou à la masse fondue pour former des filaments creux
D01F 6/36 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiquesLeur fabrication à partir de copolymères obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone comportant des acides carboxyliques non saturés ou des esters organiques non saturés comme constituant majeur
57.
MICRON AND SUBMICRON DIAMETER SPRAY DROPLET GENERATION
Disclosed herein are methods and devices for generating sprays with droplets of micron and submicron diameter. This is accomplished through the disintegration of a thin liquid film using an atomizing gas flow. The device comprises a nozzle device having at least three channels comprising an inner channel, at least one middle annular channel, outside of the inner channel, and at least one outer annular channel outside of the at least one middle annular channel, the at least one middle annular channel being coaxially arranged between the inner channel and the at least one outer annular channel and having a gap width sufficient so as to atomize a liquid flowing through the at least one middle annular channel upon flow of one or more gases through at least the inner channel and the at least one outer annular channel. The methods comprise use of the device for generating atomized particles.
B05B 15/00 - Parties constitutives des installations ou des appareillages de pulvérisation non prévus ailleursAccessoires
A61M 11/04 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression de la vapeur des liquides à pulvériser ou vaporiser
A61M 11/06 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux du type injecteur
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
The present disclosure relates to prime editing systems, compositions, and methods for altering target gene sequences and/or expression of target gene sequences.
Described herein is a method of screening for a nuclease with an altered nuclease activity comprising; a) forming a first compartmentalizing reaction comprising a carrier and a variant nuclease template nucleic acid comprising a coding region for a variant nuclease, and amplifying said coding region for said variant nuclease, to obtain variant nuclease encoding nucleic acid; b) forming a second compartmentalizing reaction comprising said variant nuclease encoding nucleic acid, and performing an in vitro transcription and translation reaction to obtain variant nuclease polypeptides; and c) forming a third compartmentalizing reaction comprising said variant nuclease polypeptides, and assaying said variant nuclease polypeptides for the altered nuclease activity of said nuclease.
C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
60.
PATH-INTEGRATED OPTICAL SENSING AND SIMULTANEOUS RETROREFLECTOR TRACKING
A retroreflector tracking and sensing technique is provided. Systems may include a laser source, optical component(s), and a beam steering component disposed along an optical transmit path. The optical component(s) may be disposed between the laser source and the beam steering component (such as a mirror coupled to an actuator). The systems may include a position-sensitive detector (PSD). The beam steering component, one or more of the optical component(s), and the PSD may be disposed along an optical return path. The optical component(s) in the optical return path may be disposed between the beam steering component and the position-sensitive detector. The PSD may be operably coupled to a position tracking analyzer and an optical sensing analyzer. Electrical signals generated by the PSD may be configured to be used for retroreflector tracking and/or optical sensing.
G01S 17/66 - Systèmes de poursuite utilisant d'autres ondes électromagnétiques que les ondes radio
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01S 7/481 - Caractéristiques de structure, p. ex. agencements d'éléments optiques
61.
SYSTEMS AND METHODS FOR SPATIO-TEMPORAL ANALYTE MEASUREMENTS OVER A FIELD USING AN OPTICAL WEB
Systems and methods are provided for measuring analytes (e.g., greenhouse gases, such as nitrous oxide) in the air over a field or other area. An optical web can be cast over the field, using a laser respectively provided from each of two or more towers disposed around an edge of the field, for the estimation of flux emissions and their spatiotemporal parameters. Each laser can be configured to provide light at a respective predetermined wavelength to one or more reflectors disposed around an edge of the field, providing a path integrated measurement, and then the light returns from the reflector to a detector that is coaligned with each respective laser. By making many such measurements, a set of linear equations can be generated, which can then be used to solve for the emission in any one grid cell of the field.
G01N 21/3504 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse des gaz, p. ex. analyse de mélanges de gaz
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01W 1/02 - Instruments pour indiquer des conditions atmosphériques par mesure de plusieurs variables, p. ex. humidité, pression, température, nébulosité ou vitesse du vent
62.
OPTICAL MATERIALS FOR SPECTRALLY SELECTIVE HEAT TRANSFER
Techniques for controlling heat transfer or emission using spectrally selective transmissive substrates are provided. Each spectrally selective transmissive substrate may include a plurality of alternating stacked layers, where the spectrally selective transmissive substrate is generally at least 50% transparent on average across a long wavelength infrared wavelength range (8 pm to 13 pm), and greater than 30% reflective on average across infrared wavelengths outside the long wavelength infrared (LWIR) wavelength range. Such substrates may include polymer such as a polyolefin, a nylon, or a polytetrafluoroethylene (PTFE), and may include air voids with a lower refractive index than polyethylene, and/or particles with a higher refractive index than polyethylene, such as ZnO. ZnS. ZnSe, CuO, FeO, Si, etc. Particles sizes are typically selected to behave as an effective medium in LWIR wavelengths, which are 5-20x larger than the particles, while still providing either solar scattering or solar transparency as desired.
F28F 13/18 - Dispositions pour modifier le transfert de chaleur, p. ex. accroissement, diminution par application de revêtements, p. ex. absorbant les radiations ou les réfléchissantDispositions pour modifier le transfert de chaleur, p. ex. accroissement, diminution par application d'un traitement de surface, p. ex. un polissage
E06B 9/24 - Écrans ou autres dispositifs protecteurs contre la lumière, notamment contre la lumière solaireÉcrans similaires pour protection de l'intimité ou pour des raisons esthétiques
B32B 17/10 - Produits stratifiés composés essentiellement d'une feuille de verre ou de fibres de verre, de scorie ou d'une substance similaire comprenant du verre comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique de résine synthétique
E04B 1/76 - Isolation thermique ou acoustique, absorption ou réflexion de la chaleur ou du sonAutres méthodes de construction procurant des conditions thermiques ou acoustiques favorables, p. ex. par accumulation de chaleur à l'intérieur des murs spécifiquement relatives à la chaleur uniquement
63.
IN-VIVO PROXIMITY-BASED LABELING SYSTEMS AND APPLICATIONS THEREOF
In one aspect, compositions and methods are described herein for providing a microenvironment mapping platform operable to selectively identify various features, including in vivo protein-protein interactions on cellular membranes. In some embodiments, a composition comprises a tetrapyrrole photocatalyst, and a protein labeling agent, wherein the tetrapyrrole photocatalyst has electronic structure to activate the protein labeling agent to a reactive intermediate via energy transfer. The reactive intermediate reacts or crosslinks with a protein or other biomolecule within the diffusion radius of the reactive intermediate.
G01N 33/80 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les groupes ou les types sanguins
64.
SYSTEM AND METHOD FOR GENERATING SYNTHETIC COUNTERFACTUALS VIA SPATIOTEMPORAL TRANSFORMERS
Disclosed is a framework called SCouT that employs a Transformer architecture to make counterfactual predictions that can be used in healthcare and other longitudinal decision-making scenarios. The disclosed approach can use longitudinal donors under an intervention to estimate the synthetic counterfactual for other units. The Transformer-based encoder-decoder model uses a causal map, which enables spatial bidirectionality, to autoregressively generate a synthetic control of a target unit.
A process for water, mineral, and/or organics recovery, as well as devices and systems that practice the process, are disclosed. The process may include providing a plurality of evaporator structures, each structure physically separated from the others, and contacting the first end of each evaporator structure with a liquid containing a plurality of materials (such as a solvent and one or more minerals). The process may include allowing capillary forces and siphonic action to draw at least one material of the plurality of materials (which may be, e.g., the solvent, a volatile organic material, and/or a mineral) from the first end towards the second end, and evaporating one or more of the plurality of materials by transferring at least one form of environmental energy (such as solar energy, wind energy, and/or ambient heat of air) directly to each evaporator structure, thereby providing the latent heat of vaporization.
Systems and methods for tackling a significant problem in data analytics: inaccurate dataset labeling. Such inaccuracies can compromise machine learning model performance. To counter this, label error detection algorithm is provided that efficiently identifies and removes samples with corrupted labels. The provided framework (CTRL) detects label errors in two steps based on the observation that models learn clean and noisy labels in different ways. First, one trains a neural network using the noisy training dataset and obtains the loss curve for each sample. Then, one applies clustering algorithms to the training losses to group samples into two categories: cleanly-labeled and noisily-labeled. After label error detection, one removes samples with noisy labels and retrains the model.
A light emitting device comprises a waveguide, a downconverting thin-film stack in optical communication with the waveguide, and an OLED thin-film stack in optical communication with the downconverting thin-film stack. An integrated photonic system comprises the downconverted as described above, wherein the downconverted OLED stack is integrated with a silicon photonic chip or CMOS photonic chip. A method for providing pump light for a silicon photonic integrated circuit comprises providing the integrated photonic as described above, producing light via the OLED thin-film stack; downconverting the produced light via the downconverting thin-film stack, and guiding the downconverted light via the waveguide.
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
A reactant comprising one or more polymers can be subjected to multiple consecutive processing cycles. Each processing cycle can have a first period with heating applied and a second period immediately following the first period with no heating applied. A duration of each processing cycle can be less than or equal to 10 seconds, and a duration of each first period can be less than 1 second. The subjecting can be effective to convert at least some of the reactant into one or more products, for example, one or more constituent monomers or other volatile or gas-phase species. In some embodiments, a reactor can be provided between a heating source and the reactant, for example, to provide a spatio-temporal temperature profile for improved polymer processing.
C08J 11/12 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation uniquement par traitement à la chaleur sèche
A base station classifier on a portable device includes code for obtaining base station resource allocations, converting the allocations into vectors to provide input to a neural network, and providing access to a trained neural network that evaluates the vectors to identify that a base station is a trusted vendor base station. A method of operations listens to resource allocations of a connected device, converts each allocation into a vector suitable for neural network analysis, evaluates the vector with a trained neural network with to determine if the vector is from a trusted base station, and connects only to base stations indicated by the trained neural network to be a trusted base station.
H04L 41/16 - Dispositions pour la maintenance, l’administration ou la gestion des réseaux de commutation de données, p. ex. des réseaux de commutation de paquets en utilisant l'apprentissage automatique ou l'intelligence artificielle
G06F 21/00 - Dispositions de sécurité pour protéger les calculateurs, leurs composants, les programmes ou les données contre une activité non autorisée
72.
INHIBITORS OF THE MTDH-SND1 PROTEIN COMPLEX FOR CANCER THERAPY
Provided herein are methods of using small molecule inhibitors of the MTDH-SND1 protein-protein interaction, such as a compound of the following structural formula: (I) or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X1, X2, X3, X4, X5, X6, X7, R3, R4, m) are as described herein. The compounds described herein can be used, for example, to treat cancer as, for example, by inhibiting metastasis of a cancer, sensitizing a cancer to treatment with an additional therapy, and/or promoting T-cell activation and/or infiltration in response to a cancer.
Provided herein are methods of using small molecule inhibitors of the MTDH-SND1 protein-protein interaction, such as a compound of the following structural formula: (I) or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X1, X2, X3, X4, X5, X6, X7, R3, R4, m) are as described herein. The compounds described herein can be used, for example, to treat cancer as, for example, by inhibiting metastasis of a cancer, sensitizing a cancer to treatment with an additional therapy, and/or promoting T-cell activation and/or infiltration in response to a cancer.
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/5025 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
The present disclosure provides methods for defining a magnet array for a stellarator. In some embodiments, the magnet array, once defined, comprises a plurality of permanent magnets, where each permanent magnet of the plurality of permanent magnets is selected from a set of predetermined permanent magnet types. In some embodiments, each predetermined permanent magnet type in the set of predetermined permanent magnet types has a predetermined shape (geometry) and/or predetermined orientation angles (also known as a polarization orientation).
Disclosed is DNA valency sorting chromatography, a purification method for separating solutes based on the number of barcoded DNA molecules present on their surface, which can operate using conventional low-pressure chromatography equipment and instrumentation. Solutes can take a variety of forms, including biological macromolecules, polymeric nanoparticles, gold or silver nanospheres, gold nanorods, iron oxide nanoparticles, and semiconducting nanocrystals. In contrast to most existing purification procedures, DNA valency sorting is highly selective for the DNA sequence specifically, rather than the characteristics of the solute as a whole, and uses extremely gentle elution conditions. As a result, it is applicable to a range of solute characteristics, including variable chemical composition, surface charge, and materials with hydrodynamic diameters up to 80 nm, which cannot be purified with a well-defined number of macromolecules by any other existing technique.
In one aspect, methods for the facile synthesis of cationic cobalt complexes for asymmetric hydrogenation of alkenes are provided. Synthetic methods described herein, in some embodiments, provide Co(I) precatalysts on a time scale and yield permitting catalytic evaluation of a significant number of enantiopure ligands.
Systems and methods are provided trajectory prediction that leverages game-theory to improve coverage of multi-modal predictions. Examples of the systems and methods include obtaining training data including first trajectories for a first plurality of agent devices and first map information of a first environment for a past time horizon and applying the training data to a game-theoretic mode-finding algorithm to generate a mode-finding model for each agent device that predicts modes of the first trajectories. A trajectory prediction model can be trained on the predicted modes as a coverage loss term between predicted modes. Future trajectories can be predicted for a second plurality of agent devices based on applying observed data to the trajectory prediction model. A control signal can then be generated to effectuate an autonomous driving command on an agent device of the second plurality of agent devices based on the predicted future trajectories.
Devices and methods for forming a spheromak plasma with targeted properties are described. The targeted properties can include a kinetic energy, an ejection speed, a plasma current, a magnetic flux, and a magnetic helicity. Examples of a high flux spheromak gun can include numerous components based on location, function, dimension, and/or constituent material. The components can include an inner electrode, an outer electrode, an inner bias coil, an outer bias coil, a ferromagnetic-core, one or more gas-puff valves, a power supply, and an electronic controller programmed to implement a magnetic flux injection scheme. Systems, such as field-reversed configuration (FRC) systems, employing the devices and methods are also described.
Disclosed is a non-transitory computer-readable storage device containing instructions that, when executed by one or more processing units, causes the one or more processing units to deploy a multi -headed deep neural network (DNN) model that includes an exemplar-replay - style continuous learning (CL) algorithm. The DNN model may be configured to receive information originating from a wearable medical sensor and receive replay data from the CL algorithm. The CL algorithm may be configured with a data preservation module and a synthetic data generation module. The data preservation module may be configured to preserve a subset of training data from one or more previous missions based on an average training loss of each data instance. The synthetic data generation module may be configured to model a probability distribution of real training data and then generate synthetic data sufficient for replays while maintaining data privacy.
A highly reliable and accurate method of assessing bacterial community viability has been developed that allows for the assessment of extremely low biomass samples, which cannot be done with traditional methods, such as qPCR. The method utilizes both PMA and droplet digital PCR (PMA-ddPCR), resulting in very accurate quantification of DNA even at very low abundances. Comparing DNA abundance in untreated samples to DNA abundance in PMA-treated samples allows the calculation of the overall viability of bacteria in any given sample. Further, PMA can be combined with traditional RNA gene sequencing (using gene-specific primers for a target species or strain) to accurately profile, e.g., the human skin microbiome, which has previously been done using traditional sequencing methods alone, but this method allows for a species-level understanding of the viable (and nonviable) components of any complex bacterial community.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
Microbial consortia exert great influence over the physiology of humans, animals, plants, and ecosystems. However, difficulty in controlling their composition and population dynamics have limited their application in medicine, agriculture, biotechnology, and the environment. The approach disclosed herein provides an effective method to dynamically control population compositions in microbial consortia, which we demonstrate in the context of co-culture fermentations for chemical production. Co-culture fermentations can improve chemical production from complex biosynthetic pathways over monocultures by distributing enzymes across multiple strains, thereby reducing metabolic burden, overcoming endogenous regulatory mechanisms, or exploiting natural traits of different microbial species. However, stabilizing and optimizing microbial sub-populations for maximal chemical production remains a major obstacle in the field. An optogenetic circuit, called OptoTA, is disclosed for regulating a toxin-antitoxin system, which enables tunability of, e.g., Escherichia coli growth using only blue light. With the disclosed system, one can control population ratios of co-cultures of, e.g., E. coli and Saccharomyces cerevisiae containing different metabolic modules of biosynthetic pathways. Results reveal that intermediate light duty cycles improve chemical production by establishing optimal co-culture populations.
C12P 17/06 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'oxygène comme unique hétéro-atome du cycle contenant un hétérocycle à six chaînons, p. ex. fluorescéine
The approach disclosed herein is a process for non-equilibrium chemical and materials processing using the combination of non-equilibrium plasma, non-equilibrium multi-functional catalysis, a precisely programed heating and quenching (PHQ), and supersonic reaction quenching to dynamically change the chemical equilibrium and increase the yield and selectivity of the products. An important feature of the disclosed approach is to realize an efficient and high selectivity synthesis method of chemicals and materials by using non-chemical equilibrium, non-equilibrium catalysts, and non-equilibrium of excited states via active control of molecule excitation by low temperature hybrid plasma, dynamics of chemical reactions by programed heating and supersonic quenching, and the design of non-equilibrium catalysts by thermal shocks and plasma coupling to enable distributed and electrified chemical synthesis of hydrogen, ammonia, valued carbon and other chemical products at atmospheric conditions. As such, the disclosed approach will enable distributed, electrified, low-carbon, and non-equilibrium chemical and material synthesis using renewable electricity, fossil fuels, biomass, and other abundant or waste resources.
Embodiments are directed to a telemetry tool that can decode all of the control messages included in a signal. The tool uses the decoded control messages in conjunction with packet statistics and other information to derive knowledge regarding network capacity, including during carrier aggregation. The tool locates and decodes the control messages within a control channel and uses a set of validation methods to ensure the control messages are decoded correctly. The tool provides valuable information that can be used to improve network efficiency and function and allow user devices to take advantage of all of a network's available bandwidth.
Disclosed is a technique for reducing CO2 to oxalate utilizing a copper-free, nickel-enhanced electrocatalyst (such as a nickel-enhanced (Cr2O3)3(Ga2O3) electrocatalyst) that can be used for producing, e.g., 1-butanol, in exceedingly high yields. Disclosed herein are various synthetic methodologies for introducing nickel into the electrocatalysts, and described is the characterization, and optimization of the Ni enhanced electrocatalysts for the reduction of CO2 to 1-butanol with a maximum faradaic efficiency ξmax of 64%, at an overpotential of 900 mV (−1.48 V vs Ag/AgCl), and having an onset overpotential of 320 mV. The product selectivity is potential dependent with other C2+ products such as 3-hydroxybutanal, (ξmax 63%) at an overpotential of 890 mV (−1.4 V vs Ag/AgCl); acetic acid with ξmax 18% at an overpotential of 390 mV (−1.0 V vs Ag/AgCl); and acetone with ξmax 10% at an overpotential of 620 mV (−1.2 V).
C25B 11/091 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques
C25B 3/07 - Composés contenant au moins un atome d’oxygène
System and techniques for in-situ carbonation in a 3D printing process may be provided. The system may include a nozzle for in-situ carbonation in a 3D printing process (e.g., of a cement). The layer-3D-printing process with induced interfaces may include a device that enables layer-wise fabrication and enhanced carbonation. Additionally, the techniques may include a design of materials architecture (arrangement) by slicing them in cellular fashion that also enhances carbonation. Further, a printable wollastonite-based paste is disclosed.
C04B 28/00 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p. ex. contenant des ciments de polycarboxylates
Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures.
Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures.
C07C 51/363 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par des réactions ne créant pas de groupes carboxyle par introduction d'atomes d'halogènePréparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par des réactions ne créant pas de groupes carboxyle par substitution d'atomes d'halogène par des atomes d'autres halogènes
C07C 67/08 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques avec le groupe hydroxyle ou O-métal de composés organiques
C07C 69/753 - Esters d'acides carboxyliques dont un groupe carboxyle est lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons d'acides polycycliques
C07C 69/757 - Esters d'acides carboxyliques dont un groupe carboxyle est lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons dont l'un des groupes OH, O-métal, —CHO, céto, éther, acyloxy, des groupes , des groupes ou des groupes se trouve dans la partie acide
C07C 69/76 - Esters d'acides carboxyliques dont un groupe carboxyle estérifié est lié à un atome de carbone d'un cycle aromatique à six chaînons
C07D 209/08 - IndolesIndoles hydrogénés avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone de l'hétérocycle
C07D 209/48 - Iso-indolesIso-indoles hydrogénés avec des atomes d'oxygène en positions 1 et 3, p. ex. phtalimide
C07D 209/88 - CarbazolesCarbazoles hydrogénés avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du système cyclique
C07D 213/26 - Radicaux substitués par des atomes d'halogènes ou par des radicaux nitro
C07D 403/08 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
Disclosed is a system and method for the controlled clustering of gene regulatory proteins at the specific target genomic loci. The technology enables formation of liquid-like droplets closely interfaced with genome organization. This technology can be utilized for perturbing endogenous nuclear structures as well as nucleating synthetic membrane-less assemblies. The technology can also be utilized for inducing or detecting mechanical stresses within the genome.
C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
Disclosed is a structured light sensor system. The system may include a beam structuring module configured to receive a laser beam from a laser source and output structured light towards a target volume. The beam structuring module designed to receive a laser beam and output a structured laser beam may comprise a spatial light modulator or a combination of axicons, or spiral phase plates, or other optical elements. This module directs the structured beam towards various optical components, which may consist of single or multimode optical fibers or free-space optics, including lenses, collimators, and mirrors, to precisely shape and guide the beam. The system may include optical element(s), including a focusing lens, configured to direct the structured light towards the target volume. The system may include additional optical element(s) configured to direct a non-reflection output response from the target volume towards a detector along a response optical path.
G02B 5/00 - Éléments optiques autres que les lentilles
G01J 3/02 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur Parties constitutives
G01J 3/10 - Aménagements de sources lumineuses spécialement adaptées à la spectrométrie ou à la colorimétrie
G01J 3/44 - Spectrométrie RamanSpectrométrie par diffusion
G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
88.
METHOD AND SYSTEMS FOR A MACHINE-ASSISTED DISCOVERY OF CHONDROITINASE ABC COMPLEXES TOWARDS SUSTAINED NEURAL REGENERATION
Disclosed are systems and methods that provide a framework for machine-assisted discovery of Chondroitinase ABC (ChABC) complexes towards sustained neural regeneration. In some embodiments, the framework may leverage a determination of a diverse set of tailor-made random copolymers that complex and stabilize ChABC at physiological temperature. The copolymer designs, which are based on chain length and/or composition of the copolymers, may be identified using an active machine learning paradigm, which involves, but is not limited to, copolymer synthesis, testing for ChABC thermostability upon copolymer complexation, Gaussian Process Regression modeling and Bayesian optimization. Copolymers are synthesized by automated PET-RAFT, and thermostability of ChABC may be assessed by retained enzyme activity (REA) after a predefined interval of hours at 37° C.
G16B 15/20 - Repliement de protéines ou de domaines
G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
G16B 15/30 - Ciblage de médicament à l’aide de données structurellesPrévision d’amarrage ou de liaison moléculaire
Disclosed is a directionally emissive device that may radiates heat skywards, but reflectively blocks longwave heat exchange with the ground. Relative to traditional building envelopes, such devices can cool buildings in the summer and heat them in the winter. Such devices generally include a micropattemed layer that includes a pattern on an outer surface that imparts a directional emittance (E), the repeating pattern defined by a repeating unit having a first surface oriented in first direction and a second surface oriented in a second direction, the first surface and the second surface being asymmetrically arranged within the repeating unit. Such devices also include an infrared (IR) reflective layer on at least a portion of the second surface, the first surface being free of the IR reflective layer.
F28F 13/18 - Dispositions pour modifier le transfert de chaleur, p. ex. accroissement, diminution par application de revêtements, p. ex. absorbant les radiations ou les réfléchissantDispositions pour modifier le transfert de chaleur, p. ex. accroissement, diminution par application d'un traitement de surface, p. ex. un polissage
F28F 3/02 - Éléments ou leurs ensembles avec moyens pour augmenter la surface de transfert de chaleur, p. ex. avec des ailettes, avec des évidements, avec des ondulations
F28F 5/00 - Éléments spécialement adaptés au mouvement
B64G 1/50 - Aménagements ou adaptations des dispositifs de contrôle de l'environnement ou des conditions de vie pour la commande de la température
E06B 9/24 - Écrans ou autres dispositifs protecteurs contre la lumière, notamment contre la lumière solaireÉcrans similaires pour protection de l'intimité ou pour des raisons esthétiques
90.
STABILIZATION OF LEAD IODIDE PEROVSKITE-BASED DEVICES
Perovskite-based devices are susceptible to degradation that stems from formation of oxidized iodine species which simultaneously facilitates degradation of both perovskite and hole transport layers. Improved devices are provided that utilized a halide perovskite layer disposed between a first electrode and a second electrode, where either the halide perovskite layer is adjacent to a reducing agent; and/or at least one intermediate layer comprising the reducing agent is between the halide perovskite layer and the first electrode, the second electrode, or both.
C09K 11/61 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du fluor, du chlore, du brome, de l'iode ou des halogènes non spécifiés
H01L 31/0232 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails - Détails Éléments ou dispositions optiques associés au dispositif
C09K 11/66 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du germanium, de l'étain ou du plomb
91.
LEARNING CLOSED-LOOP CONTROL POLICIES FOR MANUFACTURING
Institute of Science and Technology Austria (Autriche)
Universita Della Svizzera Italiana (Suisse)
Inventeur(s)
Foshey, Michael J.
Matusik, Wojciech
Bickel, Bernd
Piovarci, Michal
Rusinkiewicz, Szymon
Didyk, Piotr
Abrégé
A manufacturing system and method involves learning a self-correcting closed-loop control policy through machine reinforcement learning for a manufacturing process that involves on-the-fly adjustment of process parameters to handle inconsistencies in the manufacturing process and material formulations, and controlling operation of a tool configured to interact with or produce a product including dynamically adjusting at least one parameter of the manufacturing process to thereby dynamically adjust operation of the tool based on qualitative performance information derived from at least one sensor applied as feedback to the closed-loop control policy learned through machine reinforcement learning.
G05B 13/02 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
92.
SUBSTITUTED HETEROCYCLES AS ALDEHYDE DEHYDROGENASE INHIBITORS
Provided herein are novel heterocyclic compounds, for example, compounds of Formula (IV-C). Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
Provided herein are novel heterocyclic compounds, for example, compounds of Formula (IV-C). Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 215/50 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 4
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 491/048 - Systèmes condensés en ortho avec un seul atome d'oxygène comme hétéro-atome du cycle contenant de l'oxygène le cycle contenant de l'oxygène étant à cinq chaînons
Some embodiments of the invention provide methods that can create large area complex patterns for nanoimprint molds without or with very litter of the use of the charged beam or photon beam direct-writing of nanostructures. Some embodiments of the invention use (i) Fourier nanoimprint patterning (FNP), (ii) edge-guided nanopatterning (EGN), and (iii) nanostructure self-perfection, and their combinations.
G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
94.
SYSTEM AND METHOD FOR SUBJECT-EFFICIENT CLINICAL RANDOMIZED CONTROLLED TRIALS
Systems and methods for making a randomized control trial (RCT) more data efficient may include receiving subject data for subjects in control arm(s) or treatment arm(s) of an already-conducted RCT; estimating individual treatment effects (ITEs) by utilizing synthetic intervention (SI) to estimate counterfactual treatment responses for each patient in the control arm and counterfactual control responses for each patient in the treatment arm; conducting a two-sided hypothesis test, using the ITE for each patient and the control data; estimating a null distribution of the ITE for each patient under a null hypothesis by repeatedly resampling the control data to provide samples, and running SI with the samples; using the null distribution to determine a critical value achieving a desired significance level; and conducting the two-sided hypothesis test using the critical value. The methods may include conducting a pilot study and trend-adaptive algorithm to arrive at a sample size estimate.
G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
Embodiments are disclosed for converting audio data to studio quality audio data. The method includes obtaining an audio data having a first quality for conversion to studio quality audio. A first machine learning model predicts a set of acoustic features. A spectral mask is applied to the audio data during the prediction of the set of acoustic features. A second machine learning model generates studio quality audio from the set of acoustic features and the audio data.
G06N 5/022 - Ingénierie de la connaissanceAcquisition de la connaissance
G10L 21/0232 - Traitement dans le domaine fréquentiel
G10L 25/18 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes caractérisées par le type de paramètres extraits les paramètres extraits étant l’information spectrale de chaque sous-bande
G10L 25/24 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes caractérisées par le type de paramètres extraits les paramètres extraits étant le cepstre
G10L 25/60 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes spécialement adaptées pour un usage particulier pour comparaison ou différentiation pour mesurer la qualité des signaux de voix
96.
SYSTEM FOR GENERATING SOUND WAVES FOR AT LEAST TWO SEPARATE ZONES OF A SINGLE SPACE AND ASSOCIATED METHOD
The invention relates to a system for generating sound waves for at least two separate zones of a single space. The system includes, for each zone of said space: at least one array of high-frequency loudspeakers forming a directional sound wave; and at least one low-frequency loudspeaker. The system also comprises means for audio processing of the signals transmitted to the loudspeakers, which means control at least one loudspeaker to generate destructive sound waves in at least one zone of said space and to obtain distinct sound contents in said at least two distinct zones of said space. To do this, the audio-processing means control each low-frequency loudspeaker individually and each array of high-frequency loudspeaker mutually in order to generate the destructive sound waves.
H04S 7/00 - Dispositions pour l'indicationDispositions pour la commande, p. ex. pour la commande de l'équilibrage
H04R 1/40 - Dispositions pour obtenir la fréquence désirée ou les caractéristiques directionnelles pour obtenir la caractéristique directionnelle désirée uniquement en combinant plusieurs transducteurs identiques
Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.
G06F 12/06 - Adressage d'un bloc physique de transfert, p. ex. par adresse de base, adressage de modules, extension de l'espace d'adresse, spécialisation de mémoire
G11C 11/4074 - Circuits d'alimentation ou de génération de tension, p. ex. générateurs de tension de polarisation, générateurs de tension de substrat, alimentation de secours, circuits de commande d'alimentation
G11C 11/4094 - Circuits de commande ou de gestion de lignes de bits
G11C 11/4097 - Organisation de lignes de bits, p. ex. configuration de lignes de bits, lignes de bits repliées
H03K 19/20 - Circuits logiques, c.-à-d. ayant au moins deux entrées agissant sur une sortieCircuits d'inversion caractérisés par la fonction logique, p. ex. circuits ET, OU, NI, NON
98.
NEURAL NANO-OPTICS FOR HIGH-QUALITY THIN LENS IMAGING
Metasurfaces and systems including metasurfaces for imaging and methods of imaging are described. In one embodiment, a method for acquiring images by an imaging system comprising a metalens includes: illuminating the metalens; acquiring light passing through the metalens as a first image by an image sensor; and processing the first image into a second image that is a deconvolved version of the first image by a post-processing engine. The metalens includes a plurality of nanoposts carried by a substrate.
ddd ≤10 cm. The solar absorption material may include a plurality of layers, including a carbonaceous light absorbing layer and at least one additional layer. The at least one additional layer may include a reflective layer disposed below the carbonaceous light absorbing layer, an anti-reflection layer disposed above the carbonaceous light absorbing layer, and/or a first layer disposed above the carbonaceous light absorbing layer and any anti-reflection layer, where the first layer may consist of an anti-scaling layer, a photocatalyst layer, or a selective mineral adsorption layer.
Vinylcyclobutane (VCB) homopolymers, VCB copolymers and processes for making same. The VCB homopolymers and copolymers have a polydispersity (PDI) of less than 3.0 and are made by contacting VCB monomer in the presence of a single-site metallocene, post metallocene, or half metallocene, and an activator, under sufficient reaction conditions to produce a VCB (co)polymer having the narrow PDI of less than 3.0. The resulting poly(vinylcyclobutane) polymers have increased crystallinity and melting point properties (Tm of 165° C. to 246° C.) that are comparable to conventional polyolefins such as polyethylene (typical Tm <135° C.) and polypropylene (typical Tm <165° C.).
C08F 10/14 - Monomères contenant au moins cinq atomes de carbone
C08F 4/659 - Composant couvert par le groupe contenant une liaison métal de transition-carbone
C08F 4/6592 - Composant couvert par le groupe contenant une liaison métal de transition-carbone contenant au moins un cycle cyclopentadiényle, condensé ou non, p. ex. un cycle indényle ou fluorényle
