A process for making liquid fuels, especially diesel fuel, from primary alcohols. The process involves subjecting a feedstock comprising primary alcohols to Guerbet coupling to yield a first intermediate mix; subjecting the first intermediate mix to hydrogenolysis to yield a second intermediate mix; and subjecting the second intermediate mix to etherification to yield a liquid fuel suitable for use in internal combustion engines.
C10L 1/02 - Combustibles carbonés liquides à base essentielle de composants formés uniquement de carbone, d'hydrogène et d'oxygène
C07C 2/06 - Préparation d'hydrocarbures à partir d'hydrocarbures contenant un plus petit nombre d'atomes de carbone par addition d'hydrocarbures non saturés entre eux par oligomérisation d'hydrocarbures non saturés bien définis, sans formation de cycle d'alcènes, c.-à-d. d'hydrocarbures acycliques ne comportant qu'une seule liaison double carbone-carbone
C07C 37/16 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone d'un cycle aromatique à six chaînons par des réactions augmentant le nombre d'atomes de carbone par condensation impliquant des groupes hydroxyle de phénols ou d'alcools, ou leurs groupes éther ou ester minéral
C07C 41/09 - Préparation d'éthers par déshydratation de composés contenant des groupes hydroxyle
Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.
A synthetic triterpene composition such as squalene and methods for producing the composition by novel chemical synthesis routes is claimed. The squalene produced by the synthetic methods covered in this invention formulation is of high purity suitable for use in making vaccine adjuvants, antioxidant formulations, and drug delivery agents.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
4.
SYSTEMS AND METHODS FOR PREDICTING HIGH RESOLUTION CELL-TYPE-SPECIFIC GENE TRANSCRIPTION AND APPLICATIONS THEREOF
Systems and methods for predicting cell-type-specific gene expression from genetic sequence are described. A computational framework can comprise a computational model for predicting epigenetic regulatory markers using genetic sequence as input. A computational framework can additionally, or alternatively, comprise a computational model for predicting cell-type-specific gene expression utilizing epigenetic regulatory markers spaced along sequence of genes. The computational model for predicting cell-type-specific gene expression can be trained with single-cell genetic expression profiles, such as scRNA-seq or snRNA-seq. The computational framework can be utilized to assess polymorphic sequences, such as polymorphisms related to medical disorders. Various methods further develop research tools, perform diagnostics, and treat individuals based on cell-type-specific gene expression levels, which can be further based on differential gene expression patterns among polymorphic sequences.
Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches.
According to various embodiments, a machine-learning based system for mental health disorder identification and monitoring is disclosed. The system includes one or more processors configured to interact with a plurality of wearable medical sensors (WMSs). The processors are configured to receive physiological data from the WMSs. The processors are further configured to train at least one neural network based on raw physiological data augmented with synthetic data and subjected to a grow-and-prune paradigm to generate at least one mental health disorder inference model. The processors are also configured to output a mental health disorder-based decision by inputting the received physiological data into the generated mental health disorder inference model.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
7.
MAGNETIC ORBITAL ANGULAR MOMENTUM BEAM ACCELERATION
A magnetic orbital angular momentum beam accelerator will accelerate charged particles, electrons or ions, from rest in zero or low magnetic field into a high magnetic field regions with high kinetic energies in the form of magnetic orbital angular momentum. For example, a beam injector that accelerates electrons or ions into 1T magnetic fields with tens of keV kinetic energies transverse to the magnetic fields can be used to heat magnetically confined plasmas, to inject an initial energetic plasma component with high magnetic orbital angular momentum and to produce highly transverse particle momenta to the magnetic field for electron or ion beam lithography.
Compositions of matter and methods for using the composition of matter may be provided. The method may include providing a virus-like particle (VLP) comprising C. elegans retrotransposon 1 (Cer1) and a heterologous RNA-based agent to an organism and allowing the organism to transfer the heterologous RNA-based agent to a tissue within the organism.
Cas-cleavable reporter systems, CRISPR-Cas systems thereof, and methods of use thereof in CRISPR-Cas based diagnostics. Cas-cleavable reporter systems may generate a luminescent, fluorescent, or other detectable signal upon Cas-collateral cleavage of one or more reporter system components. CRISPR-Cas systems may comprise a Cas protein having collateral cleavage activity, guide molecules, and the Cas-cleavable reporter system. Cas-cleavable reporter systems may be a split luciferase reporter system, at least one element of which is bound to beads. For multiplexing, CRISPR-Cas systems may comprise a Cas-cleavable quenched reporter system, optionally a Cas-cleavable quenched fluorescent reporter system, a Cas protein having collateral cleavage activity, and target-specific guide molecules attached to color-coded beads. CRISPR-Cas systems may further comprise amplification reagents. Methods may apply said CRISPR-Cas systems to flow cell, well-plate, or other devices, and may measure detectable signals by microscopic, plate reader, or other methods.
Disclosed is a technique that enables structural reinforcement and thermal stabilization of the conductor winding in a superconducting coil configuration, and superconducting coils produced via the technique. The superconducting coils generally include coil windings of superconducting materials defining an electrically conductive channel having an inlet and an outlet, where the coil windings are either (i) helically wound around a curve around a central axis or (b) wound in helical layers around a curve around a central axis. One or more of the coil windings are operably coupled to at least one co-wound reinforcement layer, where the at co-wound reinforcement layer(s) are positioned between at least two adjacent superconducting coil windings or layers of superconducting coil windings. The method can significantly improve the packing factor in a coil winding while simplifying quench protection, permitting the construction of all-metal high field magnets with large bore and high magnetic field.
Disclosed herein are optogenetic circuits for the bacterium Escherichia coli that induce gene expression in darkness and repress it under blue light. Applying them to metabolic engineering improves chemical production compared to chemically induced controls in light-controlled fermentations. More particularly, these circuits can be used to control protein production with light. The system and method use light as a suitable alternative to chemical induction for microbial production of chemicals and proteins.
Disclosed are methods and a pharmaceutical composition for the prevention and treatment of fibrosis by the inhibition of fibronectin matrix assembly, as well as insights into the molecular mechanism by which cell-mediated assembly of fibronectin (FN) matrix contributes to extracellular matrix (ECM) accumulation. Peptides S2, S3, S20, and variants thereof may be utilized, either alone or fused to one or more proteins. In one aspect, a construct comprising a first protein fused to a first end of a peptide and a second protein fused to a second end of the peptide may be used, where the peptide has at least 80% sequence identity to S2, S3, or S20. The peptide may then be allowed to interact with fibronectin.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
in situin situ position detection, thickness and refractive index measurement, and/or focus control, are provided. The systems may include a first laser emitting device, a first lens, a first beam splitter and a second lens respectively forming an optical path. The second lens, the first beam splitter, a third lens, and an image detection and processing module (that includes a sensor, such as a photodiode) may form an optical return path. The second lens may be configured to continuously oscillate, as a function of time, a focal position of a laser from the first laser emitting device. The image detection and processing module may be configured to receive a reflected beam, send information related to the received beam to processing units(s), which may be configured to receive the information and determine one or more surface positions based on a temporal response of the information.
G01B 11/06 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur pour mesurer l'épaisseur
G01N 21/41 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique
Methods for co-designing transformer-accelerator pairs are provided. The methods may include using a transformer embedding to generate a computational graph and a transformer model. The methods may include running the computational graph through a surrogate model and outputting accuracy data of the surrogate model. The methods may include using an accelerator embedding and the transformer model to simulate training and inference tasks and outputting hardware performance data of the transformer model. The methods may include sending the hardware performance data (such as latency, energy leakage, dynamic energy, and chip area, which may be optimizable performance parameters) and model accuracy data to a co-design optimizer. The methods may include generating an output transformer-accelerator or a transformer-edge-device pair from the co-design optimizer. The transformer model and accelerator embedding may be the output transformer-accelerator or a transformer-edge-device pair.
Block copolymer-stabilized nanoparticles (50 nm - 1000 nm in size) of oligonucleotides with a polyethylene glycol (PEG) steric stabilizing layer are provided. Such nanoparticles may be formed using stabilizing blocks of PEG with molecular weights of 1000-5000 Dalton molecular weight, and hydrophobic anchoring blocks of a degradable polylactide and/or degradable lactide-co-glycolide polymer with molecular weights of 1000-20,000 Dalton molecular weight. The anchoring blocks may be, e.g., a polycaprolactone polymer, a polylactic acid polymer, and/or a copolymer of a lactide-co-glycolide polymer. Such nanoparticles are preferably configured to be internalized into cells and transfect cells at least as effectively as a lipid nanoparticle formulated with 1500 Dalton molecular weight PEG and Dimyristoyl glycerol (DMG) anchoring lipids.
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
Disclosed is a method to 3D print materials with defined bacterial communities into controlled, complex 3D structures, and compositions. The technique includes first providing an ink composition that includes a pre-polymer composition and a microorganism, where the pre-polymer composition includes a polymerizable monomer, a cross-linking agent, the photoinitiator, and a solvent. The technique also includes 3D printing a pattern in a hydrogel support matrix using the ink composition where the hydrogel support matrix is in a container. The technique may also include forming a 3D printed engineered living material by curing the 3D printed pattern.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B29C 64/40 - Structures de support des objets en 3D pendant la fabrication, lesdites structures devant être sacrifiées après réalisation de la fabrication
B29K 33/00 - Utilisation de polymères d'acides non saturés ou de leurs dérivés comme matière de moulage
B29K 105/00 - Présentation, forme ou état de la matière moulée
Provided are polynucleotides comprising a transcriptional control element comprising a promoter sequence having at least 80% sequence identity to SEQ ID NO: 1. SEQ ID NO:2. SEQ ID NO:3 or SEQ ID NO:4 and a cell- or tissue-specific enhancer element. Also provided are compositions (e.g., vectors, viruses, host cells, and pharmaceutical compositions) comprising said polynucleotides, methods that are useful for expressing a target gene in a host cell, and methods that are useful for expressing a target gene in a subject in need thereof.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
Systems and methods for fibrous material manufacturing are provided. The methods include dispensing a first stream of a solution (that includes a crosslinkable material) from first nozzle(s) into a bath containing a liquid (that includes a first material). The first nozzle(s) are submerged in the liquid. The methods include dispensing a second stream from second nozzle(s) also submerged in the liquid. The second stream(s) are configured to elongate and thin the first stream(s). The second stream contain a liquid. The liquid includes a second material, which may be the same, or may be different, form the first material. The methods include forming a fibrous material by crosslinking the crosslinkable material in the first stream (e.g., using a light source to cross-link a photo-crosslinkable material in the stream).
D01F 1/08 - Addition de substances à la solution de filage ou à la masse fondue pour former des filaments creux
D01F 6/36 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiquesLeur fabrication à partir de copolymères obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone comportant des acides carboxyliques non saturés ou des esters organiques non saturés comme constituant majeur
19.
THREOGLUCINS AS POTENT-ANTIBACTERIAL AGENTS AGAINST STREPTOCOCCUS SUIS
Compositions are provided that can be used to, e.g., treat or prevent infections caused by Streptococcus suis. The compositions may include one or more threoglucins in a carrier, at a total concentration of threoglucins being at least 1 μM. The at least one threoglucin may include one or more of threoglucins A-R. Such threoglucins may be produced by, e.g., growing a culture of Streptococcus suis in the presence of niacin, nicotinamide, and/or anabasine.
Disclosed herein are methods and devices for generating sprays with droplets of micron and submicron diameter. This is accomplished through the disintegration of a thin liquid film using an atomizing gas flow. The device comprises a nozzle device having at least three channels comprising an inner channel, at least one middle annular channel, outside of the inner channel, and at least one outer annular channel outside of the at least one middle annular channel, the at least one middle annular channel being coaxially arranged between the inner channel and the at least one outer annular channel and having a gap width sufficient so as to atomize a liquid flowing through the at least one middle annular channel upon flow of one or more gases through at least the inner channel and the at least one outer annular channel. The methods comprise use of the device for generating atomized particles.
B05B 15/00 - Parties constitutives des installations ou des appareillages de pulvérisation non prévus ailleursAccessoires
A61M 11/04 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression de la vapeur des liquides à pulvériser ou vaporiser
A61M 11/06 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux du type injecteur
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
The present disclosure relates to prime editing systems, compositions, and methods for altering target gene sequences and/or expression of target gene sequences.
Described herein is a method of screening for a nuclease with an altered nuclease activity comprising; a) forming a first compartmentalizing reaction comprising a carrier and a variant nuclease template nucleic acid comprising a coding region for a variant nuclease, and amplifying said coding region for said variant nuclease, to obtain variant nuclease encoding nucleic acid; b) forming a second compartmentalizing reaction comprising said variant nuclease encoding nucleic acid, and performing an in vitro transcription and translation reaction to obtain variant nuclease polypeptides; and c) forming a third compartmentalizing reaction comprising said variant nuclease polypeptides, and assaying said variant nuclease polypeptides for the altered nuclease activity of said nuclease.
C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
23.
PATH-INTEGRATED OPTICAL SENSING AND SIMULTANEOUS RETROREFLECTOR TRACKING
A retroreflector tracking and sensing technique is provided. Systems may include a laser source, optical component(s), and a beam steering component disposed along an optical transmit path. The optical component(s) may be disposed between the laser source and the beam steering component (such as a mirror coupled to an actuator). The systems may include a position-sensitive detector (PSD). The beam steering component, one or more of the optical component(s), and the PSD may be disposed along an optical return path. The optical component(s) in the optical return path may be disposed between the beam steering component and the position-sensitive detector. The PSD may be operably coupled to a position tracking analyzer and an optical sensing analyzer. Electrical signals generated by the PSD may be configured to be used for retroreflector tracking and/or optical sensing.
G01S 17/66 - Systèmes de poursuite utilisant d'autres ondes électromagnétiques que les ondes radio
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01S 7/481 - Caractéristiques de structure, p. ex. agencements d'éléments optiques
24.
SYSTEMS AND METHODS FOR SPATIO-TEMPORAL ANALYTE MEASUREMENTS OVER A FIELD USING AN OPTICAL WEB
Systems and methods are provided for measuring analytes (e.g., greenhouse gases, such as nitrous oxide) in the air over a field or other area. An optical web can be cast over the field, using a laser respectively provided from each of two or more towers disposed around an edge of the field, for the estimation of flux emissions and their spatiotemporal parameters. Each laser can be configured to provide light at a respective predetermined wavelength to one or more reflectors disposed around an edge of the field, providing a path integrated measurement, and then the light returns from the reflector to a detector that is coaligned with each respective laser. By making many such measurements, a set of linear equations can be generated, which can then be used to solve for the emission in any one grid cell of the field.
G01N 21/3504 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse des gaz, p. ex. analyse de mélanges de gaz
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01W 1/02 - Instruments pour indiquer des conditions atmosphériques par mesure de plusieurs variables, p. ex. humidité, pression, température, nébulosité ou vitesse du vent
25.
OPTICAL MATERIALS FOR SPECTRALLY SELECTIVE HEAT TRANSFER
Techniques for controlling heat transfer or emission using spectrally selective transmissive substrates are provided. Each spectrally selective transmissive substrate may include a plurality of alternating stacked layers, where the spectrally selective transmissive substrate is generally at least 50% transparent on average across a long wavelength infrared wavelength range (8 pm to 13 pm), and greater than 30% reflective on average across infrared wavelengths outside the long wavelength infrared (LWIR) wavelength range. Such substrates may include polymer such as a polyolefin, a nylon, or a polytetrafluoroethylene (PTFE), and may include air voids with a lower refractive index than polyethylene, and/or particles with a higher refractive index than polyethylene, such as ZnO. ZnS. ZnSe, CuO, FeO, Si, etc. Particles sizes are typically selected to behave as an effective medium in LWIR wavelengths, which are 5-20x larger than the particles, while still providing either solar scattering or solar transparency as desired.
F28F 13/18 - Dispositions pour modifier le transfert de chaleur, p. ex. accroissement, diminution par application de revêtements, p. ex. absorbant les radiations ou les réfléchissantDispositions pour modifier le transfert de chaleur, p. ex. accroissement, diminution par application d'un traitement de surface, p. ex. un polissage
E06B 9/24 - Écrans ou autres dispositifs protecteurs contre la lumière, notamment contre la lumière solaireÉcrans similaires pour protection de l'intimité ou pour des raisons esthétiques
B32B 17/10 - Produits stratifiés composés essentiellement d'une feuille de verre ou de fibres de verre, de scorie ou d'une substance similaire comprenant du verre comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique de résine synthétique
E04B 1/76 - Isolation thermique ou acoustique, absorption ou réflexion de la chaleur ou du sonAutres méthodes de construction procurant des conditions thermiques ou acoustiques favorables, p. ex. par accumulation de chaleur à l'intérieur des murs spécifiquement relatives à la chaleur uniquement
26.
IN-VIVO PROXIMITY-BASED LABELING SYSTEMS AND APPLICATIONS THEREOF
In one aspect, compositions and methods are described herein for providing a microenvironment mapping platform operable to selectively identify various features, including in vivo protein-protein interactions on cellular membranes. In some embodiments, a composition comprises a tetrapyrrole photocatalyst, and a protein labeling agent, wherein the tetrapyrrole photocatalyst has electronic structure to activate the protein labeling agent to a reactive intermediate via energy transfer. The reactive intermediate reacts or crosslinks with a protein or other biomolecule within the diffusion radius of the reactive intermediate.
G01N 33/80 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les groupes ou les types sanguins
27.
SYSTEM AND METHOD FOR GENERATING SYNTHETIC COUNTERFACTUALS VIA SPATIOTEMPORAL TRANSFORMERS
Disclosed is a framework called SCouT that employs a Transformer architecture to make counterfactual predictions that can be used in healthcare and other longitudinal decision-making scenarios. The disclosed approach can use longitudinal donors under an intervention to estimate the synthetic counterfactual for other units. The Transformer-based encoder-decoder model uses a causal map, which enables spatial bidirectionality, to autoregressively generate a synthetic control of a target unit.
A process for water, mineral, and/or organics recovery, as well as devices and systems that practice the process, are disclosed. The process may include providing a plurality of evaporator structures, each structure physically separated from the others, and contacting the first end of each evaporator structure with a liquid containing a plurality of materials (such as a solvent and one or more minerals). The process may include allowing capillary forces and siphonic action to draw at least one material of the plurality of materials (which may be, e.g., the solvent, a volatile organic material, and/or a mineral) from the first end towards the second end, and evaporating one or more of the plurality of materials by transferring at least one form of environmental energy (such as solar energy, wind energy, and/or ambient heat of air) directly to each evaporator structure, thereby providing the latent heat of vaporization.
Systems and methods for tackling a significant problem in data analytics: inaccurate dataset labeling. Such inaccuracies can compromise machine learning model performance. To counter this, label error detection algorithm is provided that efficiently identifies and removes samples with corrupted labels. The provided framework (CTRL) detects label errors in two steps based on the observation that models learn clean and noisy labels in different ways. First, one trains a neural network using the noisy training dataset and obtains the loss curve for each sample. Then, one applies clustering algorithms to the training losses to group samples into two categories: cleanly-labeled and noisily-labeled. After label error detection, one removes samples with noisy labels and retrains the model.
A light emitting device comprises a waveguide, a downconverting thin-film stack in optical communication with the waveguide, and an OLED thin-film stack in optical communication with the downconverting thin-film stack. An integrated photonic system comprises the downconverted as described above, wherein the downconverted OLED stack is integrated with a silicon photonic chip or CMOS photonic chip. A method for providing pump light for a silicon photonic integrated circuit comprises providing the integrated photonic as described above, producing light via the OLED thin-film stack; downconverting the produced light via the downconverting thin-film stack, and guiding the downconverted light via the waveguide.
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
A reactant comprising one or more polymers can be subjected to multiple consecutive processing cycles. Each processing cycle can have a first period with heating applied and a second period immediately following the first period with no heating applied. A duration of each processing cycle can be less than or equal to 10 seconds, and a duration of each first period can be less than 1 second. The subjecting can be effective to convert at least some of the reactant into one or more products, for example, one or more constituent monomers or other volatile or gas-phase species. In some embodiments, a reactor can be provided between a heating source and the reactant, for example, to provide a spatio-temporal temperature profile for improved polymer processing.
C08J 11/12 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation uniquement par traitement à la chaleur sèche
A base station classifier on a portable device includes code for obtaining base station resource allocations, converting the allocations into vectors to provide input to a neural network, and providing access to a trained neural network that evaluates the vectors to identify that a base station is a trusted vendor base station. A method of operations listens to resource allocations of a connected device, converts each allocation into a vector suitable for neural network analysis, evaluates the vector with a trained neural network with to determine if the vector is from a trusted base station, and connects only to base stations indicated by the trained neural network to be a trusted base station.
H04L 41/16 - Dispositions pour la maintenance, l’administration ou la gestion des réseaux de commutation de données, p. ex. des réseaux de commutation de paquets en utilisant l'apprentissage automatique ou l'intelligence artificielle
G06F 21/00 - Dispositions de sécurité pour protéger les calculateurs, leurs composants, les programmes ou les données contre une activité non autorisée
35.
INHIBITORS OF THE MTDH-SND1 PROTEIN COMPLEX FOR CANCER THERAPY
Provided herein are methods of using small molecule inhibitors of the MTDH-SND1 protein-protein interaction, such as a compound of the following structural formula: (I) or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X1, X2, X3, X4, X5, X6, X7, R3, R4, m) are as described herein. The compounds described herein can be used, for example, to treat cancer as, for example, by inhibiting metastasis of a cancer, sensitizing a cancer to treatment with an additional therapy, and/or promoting T-cell activation and/or infiltration in response to a cancer.
Provided herein are methods of using small molecule inhibitors of the MTDH-SND1 protein-protein interaction, such as a compound of the following structural formula: (I) or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X1, X2, X3, X4, X5, X6, X7, R3, R4, m) are as described herein. The compounds described herein can be used, for example, to treat cancer as, for example, by inhibiting metastasis of a cancer, sensitizing a cancer to treatment with an additional therapy, and/or promoting T-cell activation and/or infiltration in response to a cancer.
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/5025 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
Disclosed is DNA valency sorting chromatography, a purification method for separating solutes based on the number of barcoded DNA molecules present on their surface, which can operate using conventional low-pressure chromatography equipment and instrumentation. Solutes can take a variety of forms, including biological macromolecules, polymeric nanoparticles, gold or silver nanospheres, gold nanorods, iron oxide nanoparticles, and semiconducting nanocrystals. In contrast to most existing purification procedures, DNA valency sorting is highly selective for the DNA sequence specifically, rather than the characteristics of the solute as a whole, and uses extremely gentle elution conditions. As a result, it is applicable to a range of solute characteristics, including variable chemical composition, surface charge, and materials with hydrodynamic diameters up to 80 nm, which cannot be purified with a well-defined number of macromolecules by any other existing technique.
In one aspect, methods for the facile synthesis of cationic cobalt complexes for asymmetric hydrogenation of alkenes are provided. Synthetic methods described herein, in some embodiments, provide Co(I) precatalysts on a time scale and yield permitting catalytic evaluation of a significant number of enantiopure ligands.
The present disclosure provides methods for defining a magnet array for a stellarator. In some embodiments, the magnet array, once defined, comprises a plurality of permanent magnets, where each permanent magnet of the plurality of permanent magnets is selected from a set of predetermined permanent magnet types. In some embodiments, each predetermined permanent magnet type in the set of predetermined permanent magnet types has a predetermined shape (geometry) and/or predetermined orientation angles (also known as a polarization orientation).
Systems and methods are provided trajectory prediction that leverages game-theory to improve coverage of multi-modal predictions. Examples of the systems and methods include obtaining training data including first trajectories for a first plurality of agent devices and first map information of a first environment for a past time horizon and applying the training data to a game-theoretic mode-finding algorithm to generate a mode-finding model for each agent device that predicts modes of the first trajectories. A trajectory prediction model can be trained on the predicted modes as a coverage loss term between predicted modes. Future trajectories can be predicted for a second plurality of agent devices based on applying observed data to the trajectory prediction model. A control signal can then be generated to effectuate an autonomous driving command on an agent device of the second plurality of agent devices based on the predicted future trajectories.
Devices and methods for forming a spheromak plasma with targeted properties are described. The targeted properties can include a kinetic energy, an ejection speed, a plasma current, a magnetic flux, and a magnetic helicity. Examples of a high flux spheromak gun can include numerous components based on location, function, dimension, and/or constituent material. The components can include an inner electrode, an outer electrode, an inner bias coil, an outer bias coil, a ferromagnetic-core, one or more gas-puff valves, a power supply, and an electronic controller programmed to implement a magnetic flux injection scheme. Systems, such as field-reversed configuration (FRC) systems, employing the devices and methods are also described.
Disclosed is a non-transitory computer-readable storage device containing instructions that, when executed by one or more processing units, causes the one or more processing units to deploy a multi -headed deep neural network (DNN) model that includes an exemplar-replay - style continuous learning (CL) algorithm. The DNN model may be configured to receive information originating from a wearable medical sensor and receive replay data from the CL algorithm. The CL algorithm may be configured with a data preservation module and a synthetic data generation module. The data preservation module may be configured to preserve a subset of training data from one or more previous missions based on an average training loss of each data instance. The synthetic data generation module may be configured to model a probability distribution of real training data and then generate synthetic data sufficient for replays while maintaining data privacy.
A highly reliable and accurate method of assessing bacterial community viability has been developed that allows for the assessment of extremely low biomass samples, which cannot be done with traditional methods, such as qPCR. The method utilizes both PMA and droplet digital PCR (PMA-ddPCR), resulting in very accurate quantification of DNA even at very low abundances. Comparing DNA abundance in untreated samples to DNA abundance in PMA-treated samples allows the calculation of the overall viability of bacteria in any given sample. Further, PMA can be combined with traditional RNA gene sequencing (using gene-specific primers for a target species or strain) to accurately profile, e.g., the human skin microbiome, which has previously been done using traditional sequencing methods alone, but this method allows for a species-level understanding of the viable (and nonviable) components of any complex bacterial community.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
The approach disclosed herein is a process for non-equilibrium chemical and materials processing using the combination of non-equilibrium plasma, non-equilibrium multi-functional catalysis, a precisely programed heating and quenching (PHQ), and supersonic reaction quenching to dynamically change the chemical equilibrium and increase the yield and selectivity of the products. An important feature of the disclosed approach is to realize an efficient and high selectivity synthesis method of chemicals and materials by using non-chemical equilibrium, non-equilibrium catalysts, and non-equilibrium of excited states via active control of molecule excitation by low temperature hybrid plasma, dynamics of chemical reactions by programed heating and supersonic quenching, and the design of non-equilibrium catalysts by thermal shocks and plasma coupling to enable distributed and electrified chemical synthesis of hydrogen, ammonia, valued carbon and other chemical products at atmospheric conditions. As such, the disclosed approach will enable distributed, electrified, low-carbon, and non-equilibrium chemical and material synthesis using renewable electricity, fossil fuels, biomass, and other abundant or waste resources.
Microbial consortia exert great influence over the physiology of humans, animals, plants, and ecosystems. However, difficulty in controlling their composition and population dynamics have limited their application in medicine, agriculture, biotechnology, and the environment. The approach disclosed herein provides an effective method to dynamically control population compositions in microbial consortia, which we demonstrate in the context of co-culture fermentations for chemical production. Co-culture fermentations can improve chemical production from complex biosynthetic pathways over monocultures by distributing enzymes across multiple strains, thereby reducing metabolic burden, overcoming endogenous regulatory mechanisms, or exploiting natural traits of different microbial species. However, stabilizing and optimizing microbial sub-populations for maximal chemical production remains a major obstacle in the field. An optogenetic circuit, called OptoTA, is disclosed for regulating a toxin-antitoxin system, which enables tunability of, e.g., Escherichia coli growth using only blue light. With the disclosed system, one can control population ratios of co-cultures of, e.g., E. coli and Saccharomyces cerevisiae containing different metabolic modules of biosynthetic pathways. Results reveal that intermediate light duty cycles improve chemical production by establishing optimal co-culture populations.
C12P 17/06 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'oxygène comme unique hétéro-atome du cycle contenant un hétérocycle à six chaînons, p. ex. fluorescéine
Embodiments are directed to a telemetry tool that can decode all of the control messages included in a signal. The tool uses the decoded control messages in conjunction with packet statistics and other information to derive knowledge regarding network capacity, including during carrier aggregation. The tool locates and decodes the control messages within a control channel and uses a set of validation methods to ensure the control messages are decoded correctly. The tool provides valuable information that can be used to improve network efficiency and function and allow user devices to take advantage of all of a network's available bandwidth.
Disclosed is a technique for reducing CO2 to oxalate utilizing a copper-free, nickel-enhanced electrocatalyst (such as a nickel-enhanced (Cr2O3)3(Ga2O3) electrocatalyst) that can be used for producing, e.g., 1-butanol, in exceedingly high yields. Disclosed herein are various synthetic methodologies for introducing nickel into the electrocatalysts, and described is the characterization, and optimization of the Ni enhanced electrocatalysts for the reduction of CO2 to 1-butanol with a maximum faradaic efficiency ξmax of 64%, at an overpotential of 900 mV (−1.48 V vs Ag/AgCl), and having an onset overpotential of 320 mV. The product selectivity is potential dependent with other C2+ products such as 3-hydroxybutanal, (ξmax 63%) at an overpotential of 890 mV (−1.4 V vs Ag/AgCl); acetic acid with ξmax 18% at an overpotential of 390 mV (−1.0 V vs Ag/AgCl); and acetone with ξmax 10% at an overpotential of 620 mV (−1.2 V).
C25B 11/091 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques
C25B 3/07 - Composés contenant au moins un atome d’oxygène
System and techniques for in-situ carbonation in a 3D printing process may be provided. The system may include a nozzle for in-situ carbonation in a 3D printing process (e.g., of a cement). The layer-3D-printing process with induced interfaces may include a device that enables layer-wise fabrication and enhanced carbonation. Additionally, the techniques may include a design of materials architecture (arrangement) by slicing them in cellular fashion that also enhances carbonation. Further, a printable wollastonite-based paste is disclosed.
C04B 28/00 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p. ex. contenant des ciments de polycarboxylates
Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures.
Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures.
C07C 51/363 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par des réactions ne créant pas de groupes carboxyle par introduction d'atomes d'halogènePréparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par des réactions ne créant pas de groupes carboxyle par substitution d'atomes d'halogène par des atomes d'autres halogènes
C07C 67/08 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques avec le groupe hydroxyle ou O-métal de composés organiques
C07C 69/753 - Esters d'acides carboxyliques dont un groupe carboxyle est lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons d'acides polycycliques
C07C 69/757 - Esters d'acides carboxyliques dont un groupe carboxyle est lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons dont l'un des groupes OH, O-métal, —CHO, céto, éther, acyloxy, des groupes , des groupes ou des groupes se trouve dans la partie acide
C07C 69/76 - Esters d'acides carboxyliques dont un groupe carboxyle estérifié est lié à un atome de carbone d'un cycle aromatique à six chaînons
C07D 209/08 - IndolesIndoles hydrogénés avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone de l'hétérocycle
C07D 209/48 - Iso-indolesIso-indoles hydrogénés avec des atomes d'oxygène en positions 1 et 3, p. ex. phtalimide
C07D 209/88 - CarbazolesCarbazoles hydrogénés avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du système cyclique
C07D 213/26 - Radicaux substitués par des atomes d'halogènes ou par des radicaux nitro
C07D 403/08 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
Disclosed is a system and method for the controlled clustering of gene regulatory proteins at the specific target genomic loci. The technology enables formation of liquid-like droplets closely interfaced with genome organization. This technology can be utilized for perturbing endogenous nuclear structures as well as nucleating synthetic membrane-less assemblies. The technology can also be utilized for inducing or detecting mechanical stresses within the genome.
C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
Disclosed is a structured light sensor system. The system may include a beam structuring module configured to receive a laser beam from a laser source and output structured light towards a target volume. The beam structuring module designed to receive a laser beam and output a structured laser beam may comprise a spatial light modulator or a combination of axicons, or spiral phase plates, or other optical elements. This module directs the structured beam towards various optical components, which may consist of single or multimode optical fibers or free-space optics, including lenses, collimators, and mirrors, to precisely shape and guide the beam. The system may include optical element(s), including a focusing lens, configured to direct the structured light towards the target volume. The system may include additional optical element(s) configured to direct a non-reflection output response from the target volume towards a detector along a response optical path.
G02B 5/00 - Éléments optiques autres que les lentilles
G01J 3/02 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur Parties constitutives
G01J 3/10 - Aménagements de sources lumineuses spécialement adaptées à la spectrométrie ou à la colorimétrie
G01J 3/44 - Spectrométrie RamanSpectrométrie par diffusion
G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
51.
METHOD AND SYSTEMS FOR A MACHINE-ASSISTED DISCOVERY OF CHONDROITINASE ABC COMPLEXES TOWARDS SUSTAINED NEURAL REGENERATION
Disclosed are systems and methods that provide a framework for machine-assisted discovery of Chondroitinase ABC (ChABC) complexes towards sustained neural regeneration. In some embodiments, the framework may leverage a determination of a diverse set of tailor-made random copolymers that complex and stabilize ChABC at physiological temperature. The copolymer designs, which are based on chain length and/or composition of the copolymers, may be identified using an active machine learning paradigm, which involves, but is not limited to, copolymer synthesis, testing for ChABC thermostability upon copolymer complexation, Gaussian Process Regression modeling and Bayesian optimization. Copolymers are synthesized by automated PET-RAFT, and thermostability of ChABC may be assessed by retained enzyme activity (REA) after a predefined interval of hours at 37° C.
G16B 15/20 - Repliement de protéines ou de domaines
G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
G16B 15/30 - Ciblage de médicament à l’aide de données structurellesPrévision d’amarrage ou de liaison moléculaire
Disclosed is a directionally emissive device that may radiates heat skywards, but reflectively blocks longwave heat exchange with the ground. Relative to traditional building envelopes, such devices can cool buildings in the summer and heat them in the winter. Such devices generally include a micropattemed layer that includes a pattern on an outer surface that imparts a directional emittance (E), the repeating pattern defined by a repeating unit having a first surface oriented in first direction and a second surface oriented in a second direction, the first surface and the second surface being asymmetrically arranged within the repeating unit. Such devices also include an infrared (IR) reflective layer on at least a portion of the second surface, the first surface being free of the IR reflective layer.
53.
STABILIZATION OF LEAD IODIDE PEROVSKITE-BASED DEVICES
Perovskite-based devices are susceptible to degradation that stems from formation of oxidized iodine species which simultaneously facilitates degradation of both perovskite and hole transport layers. Improved devices are provided that utilized a halide perovskite layer disposed between a first electrode and a second electrode, where either the halide perovskite layer is adjacent to a reducing agent; and/or at least one intermediate layer comprising the reducing agent is between the halide perovskite layer and the first electrode, the second electrode, or both.
C09K 11/61 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du fluor, du chlore, du brome, de l'iode ou des halogènes non spécifiés
H01L 31/0232 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails - Détails Éléments ou dispositions optiques associés au dispositif
C09K 11/66 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du germanium, de l'étain ou du plomb
54.
LEARNING CLOSED-LOOP CONTROL POLICIES FOR MANUFACTURING
Institute of Science and Technology Austria (Autriche)
Universita Della Svizzera Italiana (Suisse)
Inventeur(s)
Foshey, Michael J.
Matusik, Wojciech
Bickel, Bernd
Piovarci, Michal
Rusinkiewicz, Szymon
Didyk, Piotr
Abrégé
A manufacturing system and method involves learning a self-correcting closed-loop control policy through machine reinforcement learning for a manufacturing process that involves on-the-fly adjustment of process parameters to handle inconsistencies in the manufacturing process and material formulations, and controlling operation of a tool configured to interact with or produce a product including dynamically adjusting at least one parameter of the manufacturing process to thereby dynamically adjust operation of the tool based on qualitative performance information derived from at least one sensor applied as feedback to the closed-loop control policy learned through machine reinforcement learning.
G05B 13/02 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
55.
SUBSTITUTED HETEROCYCLES AS ALDEHYDE DEHYDROGENASE INHIBITORS
Provided herein are novel heterocyclic compounds, for example, compounds of Formula (IV-C). Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
Provided herein are novel heterocyclic compounds, for example, compounds of Formula (IV-C). Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 215/50 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 4
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 491/048 - Systèmes condensés en ortho avec un seul atome d'oxygène comme hétéro-atome du cycle contenant de l'oxygène le cycle contenant de l'oxygène étant à cinq chaînons
Some embodiments of the invention provide methods that can create large area complex patterns for nanoimprint molds without or with very litter of the use of the charged beam or photon beam direct-writing of nanostructures. Some embodiments of the invention use (i) Fourier nanoimprint patterning (FNP), (ii) edge-guided nanopatterning (EGN), and (iii) nanostructure self-perfection, and their combinations.
G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
57.
SYSTEM AND METHOD FOR SUBJECT-EFFICIENT CLINICAL RANDOMIZED CONTROLLED TRIALS
Systems and methods for making a randomized control trial (RCT) more data efficient may include receiving subject data for subjects in control arm(s) or treatment arm(s) of an already-conducted RCT; estimating individual treatment effects (ITEs) by utilizing synthetic intervention (SI) to estimate counterfactual treatment responses for each patient in the control arm and counterfactual control responses for each patient in the treatment arm; conducting a two-sided hypothesis test, using the ITE for each patient and the control data; estimating a null distribution of the ITE for each patient under a null hypothesis by repeatedly resampling the control data to provide samples, and running SI with the samples; using the null distribution to determine a critical value achieving a desired significance level; and conducting the two-sided hypothesis test using the critical value. The methods may include conducting a pilot study and trend-adaptive algorithm to arrive at a sample size estimate.
G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
Embodiments are disclosed for converting audio data to studio quality audio data. The method includes obtaining an audio data having a first quality for conversion to studio quality audio. A first machine learning model predicts a set of acoustic features. A spectral mask is applied to the audio data during the prediction of the set of acoustic features. A second machine learning model generates studio quality audio from the set of acoustic features and the audio data.
G06N 5/022 - Ingénierie de la connaissanceAcquisition de la connaissance
G10L 21/0232 - Traitement dans le domaine fréquentiel
G10L 25/18 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes caractérisées par le type de paramètres extraits les paramètres extraits étant l’information spectrale de chaque sous-bande
G10L 25/24 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes caractérisées par le type de paramètres extraits les paramètres extraits étant le cepstre
G10L 25/60 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes spécialement adaptées pour un usage particulier pour comparaison ou différentiation pour mesurer la qualité des signaux de voix
59.
SYSTEM FOR GENERATING SOUND WAVES FOR AT LEAST TWO SEPARATE ZONES OF A SINGLE SPACE AND ASSOCIATED METHOD
The invention relates to a system for generating sound waves for at least two separate zones of a single space. The system includes, for each zone of said space: at least one array of high-frequency loudspeakers forming a directional sound wave; and at least one low-frequency loudspeaker. The system also comprises means for audio processing of the signals transmitted to the loudspeakers, which means control at least one loudspeaker to generate destructive sound waves in at least one zone of said space and to obtain distinct sound contents in said at least two distinct zones of said space. To do this, the audio-processing means control each low-frequency loudspeaker individually and each array of high-frequency loudspeaker mutually in order to generate the destructive sound waves.
H04S 7/00 - Dispositions pour l'indicationDispositions pour la commande, p. ex. pour la commande de l'équilibrage
H04R 1/40 - Dispositions pour obtenir la fréquence désirée ou les caractéristiques directionnelles pour obtenir la caractéristique directionnelle désirée uniquement en combinant plusieurs transducteurs identiques
Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.
G06F 12/06 - Adressage d'un bloc physique de transfert, p. ex. par adresse de base, adressage de modules, extension de l'espace d'adresse, spécialisation de mémoire
G11C 11/4074 - Circuits d'alimentation ou de génération de tension, p. ex. générateurs de tension de polarisation, générateurs de tension de substrat, alimentation de secours, circuits de commande d'alimentation
G11C 11/4094 - Circuits de commande ou de gestion de lignes de bits
G11C 11/4097 - Organisation de lignes de bits, p. ex. configuration de lignes de bits, lignes de bits repliées
H03K 19/20 - Circuits logiques, c.-à-d. ayant au moins deux entrées agissant sur une sortieCircuits d'inversion caractérisés par la fonction logique, p. ex. circuits ET, OU, NI, NON
61.
NEURAL NANO-OPTICS FOR HIGH-QUALITY THIN LENS IMAGING
Metasurfaces and systems including metasurfaces for imaging and methods of imaging are described. In one embodiment, a method for acquiring images by an imaging system comprising a metalens includes: illuminating the metalens; acquiring light passing through the metalens as a first image by an image sensor; and processing the first image into a second image that is a deconvolved version of the first image by a post-processing engine. The metalens includes a plurality of nanoposts carried by a substrate.
ddd ≤10 cm. The solar absorption material may include a plurality of layers, including a carbonaceous light absorbing layer and at least one additional layer. The at least one additional layer may include a reflective layer disposed below the carbonaceous light absorbing layer, an anti-reflection layer disposed above the carbonaceous light absorbing layer, and/or a first layer disposed above the carbonaceous light absorbing layer and any anti-reflection layer, where the first layer may consist of an anti-scaling layer, a photocatalyst layer, or a selective mineral adsorption layer.
Vinylcyclobutane (VCB) homopolymers, VCB copolymers and processes for making same. The VCB homopolymers and copolymers have a polydispersity (PDI) of less than 3.0 and are made by contacting VCB monomer in the presence of a single-site metallocene, post metallocene, or half metallocene, and an activator, under sufficient reaction conditions to produce a VCB (co)polymer having the narrow PDI of less than 3.0. The resulting poly(vinylcyclobutane) polymers have increased crystallinity and melting point properties (Tm of 165° C. to 246° C.) that are comparable to conventional polyolefins such as polyethylene (typical Tm <135° C.) and polypropylene (typical Tm <165° C.).
C08F 10/14 - Monomères contenant au moins cinq atomes de carbone
C08F 4/659 - Composant couvert par le groupe contenant une liaison métal de transition-carbone
C08F 4/6592 - Composant couvert par le groupe contenant une liaison métal de transition-carbone contenant au moins un cycle cyclopentadiényle, condensé ou non, p. ex. un cycle indényle ou fluorényle
An organic optoelectronic device comprises a first electrode, a first charge transport layer positioned over the first electrode, a first emissive layer positioned over the first charge transport layer, a second charge transport layer positioned over the first emissive layer, a second electrode positioned over the second charge transport layer, and a top organic emissive layer positioned over the second electrode, configured to convert surface plasmon polaritons on a surface of the second electrode to light. A white emitting organic optoelectronic device and a method for transferring energy to acceptor molecules are also disclosed.
H10K 59/95 - Ensembles de plusieurs dispositifs comprenant au moins un élément organique émetteur de lumière dans lesquels tous les éléments émetteurs de lumière sont organiques, p. ex. ensembles d'affichages à OLED
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
The present disclosure provides compositions of matter comprising a polymer or peptide bound to an oxidized amino acid or an analog thereof. The present disclosure also provides packaging materials, consumer products, and cosmetic products comprising the compositions of matter disclosed herein.
Systems and methods disclosed herein provide for a passive backscattering beamformer based on large-area electronics (LAE). Low power is critical for distributed nodes in future IoT/5G networks. A key emerging solution is using ubiquitous 2.4 GHz Wi-Fi infrastructure with passive backscattering nodes, for low-power communication. LAE enables monolithic integration of devices over large and flexible substrates, with recent advances into the gigahertz regime opening new opportunities for wireless systems. An LAE passive backscattering beamformer is chosen that is capable of (1) enhancing the backscattered signal power in a scalable manner enabled by LAE's monolithic integrability over meter-scale area; (2) configuration between constructive/destructive beamforming; (3) frequency-shift keying for data modulation and SNR enhancement, by shifting the signal away from the incident interferer; and (4) frequency division multiplexing for increasing data bandwidth.
A design methodology and tool called INFORM are provided that use a two-phase approach for sample-efficient constrained multi-objective optimization of real -world nonlinear systems. In the first optional phase, one may modify a genetic algorithm (GA) to make the design process sample-efficient, and may inject candidate solutions into the GA population using inverse design methods. The inverse design techniques may be based on (i) a neural network verifier, (ii) a neural network, and (iii) a Gaussian mixture model. The candidate solutions for the next generation are thus a mix of those generated using crossover/mutation and solutions generated using inverse design. At the end of the first phase, one obtains a set of nondominated solutions. In the second phase, one chooses one or more solution(s) from the non-dominated solutions or another reference solution to further improve the objective function values using inverse design methods.
G06N 3/126 - Algorithmes évolutionnaires, p. ex. algorithmes génétiques ou programmation génétique
G06F 18/2115 - Sélection du sous-ensemble de caractéristiques le plus significatif en évaluant différents sous-ensembles en fonction d'un critère d'optimisation, p. ex. la séparabilité des classes, la sélection en avant ou l’élimination en arrière
68.
Opposite Anharmonicity Coupler For Gates In Quantum Computers
Disclosed herein are methods, systems, and devices including a tunable coupler design that harnesses interference due to higher energy levels to achieve zero static ZZ coupling between the two qubits. Biasing to zero ZZ interaction, a fast perfect entangler is realized with parametric flux modulation in less than 20 ns. The disclosed coupler provides very fast gates between far-detuned fixed frequency qubits, and is a crucial building block in scaled quantum computers.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
69.
METHODS OF SCREENING INHIBITORS OF BIOMOLECULAR INTERACTIONS USING PHASE SEPARATION AS IN CELLULO READ-OUT
Provided herein are methods of identifying an inhibitory activity of an exogeneous agent that disrupts binding of a target peptide to a biomolecule using phase separation as in cellulo read-out. Provided herein also are kits for the methods, pharmaceutical compositions comprising the agents screened by the methods, methods of preparing the pharmaceutical composition, and methods of treating a disease or condition in a subject in need thereof by administering the pharmaceutical composition.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
70.
SYSTEM AND METHOD FOR CONTROLLING THE SOUNDSTAGE RENDERED BY LOUDSPEAKERS
The present disclosure relates to a method for designing a sound stage control (SSC) processor to control a sound stage rendered by distributed loudspeakers in acoustically reflective environments. The method includes step A, including designing of Alignment Stage filters, step B, including measuring the response from the different loudspeakers to the same control points with the Alignment Stage filters applied, step C including pre-processing of the response obtained in step B by time-windowing impulse responses in a frequency-dependent manner, a step D including inverting of pre-processed IRs obtained from the step C; and a step E including cascading of the Alignment Stage and SSC Stage to program the SSC processor.
Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
C07K 1/113 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs sans changement de la structure primaire
B01J 31/18 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination contenant de l'azote, du phosphore, de l'arsenic ou de l'antimoine
C07K 1/107 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs
C07K 5/02 - Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminéeLeurs dérivés contenant au moins une liaison peptidique anormale
The present invention provides, in some embodiments, methods of promoting an immune response in a subject in need thereof, comprising administering to a subject a population of immune cells that express an exogenous enzyme that facilitates immune cell function in a nutrient-poor environment. Other embodiments of the invention include methods of promoting an immune response to a tumor in a subject in need thereof, comprising administering to the subject an effective amount of an agent that provides a one-carbon unit (e.g., formate) and an agent that promotes an anti-tumor response, and methods of promoting an immune response to a tumor in a subject in need thereof, comprising administering to a subject an effective amount of an agent that inhibits consumption of metabolic fuels by tumor cells. The invention also provides, in other embodiments, compositions comprising an ex vivo population of immune cells expressing an exogenous enzyme that enhances immune cell function in nutrient poor environments, and compositions comprising a nucleic acid expression construct encoding an inhibitor of glucose metabolism, and a pharmaceutically acceptable carrier or excipient.
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
73.
METHODS, DEVICES AND COMPOSITIONS FOR PRESERVING HUMAN MILK
Described herein, are compositions and methods for preserving human milk, preventing rancidity of human milk, extending shelf life of human milk, and maintaining the nutritional properties of human milk. Specifically, the present disclosure provides, among other things, devices for storing preserved human milk and methods and compositions for preserving the same.
A23C 3/08 - Conservation du lait ou de préparations à base de lait par addition d'agents de conservation
A23C 9/152 - Préparations à base de laitLait en poudre ou préparations à base de lait en poudre comportant des additifs
A23C 9/158 - Préparations à base de laitLait en poudre ou préparations à base de lait en poudre comportant des additifs contenant des vitamines ou des antibiotiques
Discontinuity modeling techniques of computing functions of a program are described. In one example, a program has a computing function that includes a discontinuity. An input is received by the data modeling system that identifies an axis. A plurality of samples is then generated by the data modeling system along the axis based on an output of the program. The samples are then used as a basis by the data modeling system to generate a data model that models the discontinuity. The data model includes, in one example, one or more gradients and models the discontinuity using a 1D box kernel.
G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
G06N 3/084 - Rétropropagation, p. ex. suivant l’algorithme du gradient
Various devices and systems related to mobile robotic devices may be provided, along with improved techniques for controlling such mobile robotic devices. Specific configurations of mobile robotic devices, including systems comprising multiple robotic devices that can be coupled together. The devices may include at least one processing unit configured to control positioning and/or rotation of each of the plurality of contact elements in a specific manner, that generally includes encoding discrete dynamic modes with contact statuses for each of the plurality of contact elements, and constructing appropriate equations of motion and constraint equations, and when discrete mode transitions arise, updating discrete mode encodings and applying continuous state reset mappings. Additionally, devices including pulleys and belts may be provided, where the belts may be looped around idlers that are coupled to an intermediate rotary element. Desirable configurations of such devices include differentials, speed reducers, and torque vectoring mechanisms.
Described herein, are compositions and methods for preserving human milk, preventing rancidity of human milk, extending shelf life of human milk, and maintaining the nutritional properties of human milk. Specifically, the present disclosure provides, among other things, devices for storing preserved human milk and methods and compositions for preserving the same.
Disclosed is a method for experimentally optimizing information quality and engagement in crowd sourced evaluation systems. It allows estimating efficiencies of different strategies to provide the greatest opportunity for social learning. It can be used for continuous tuning of social feedback. Also disclosed is a system that allows experimentation with crowd sourced evaluations of virtual services. The experimental system supports large scale online recruitment of participants into web-browser 3D virtual world. The virtual world can be designed to approximate several types of real-world, distributed information systems. Social influences can be experimentally introduced into the feedback system in order to empirically optimize its utility.
A63F 13/63 - Création ou modification du contenu du jeu avant ou pendant l’exécution du programme de jeu, p. ex. au moyen d’outils spécialement adaptés au développement du jeu ou d’un éditeur de niveau intégré au jeu par le joueur, p. ex. avec un éditeur de niveaux
A63F 13/71 - Aspects de sécurité ou de gestion du jeu utilisation d'une communication sécurisée entre les dispositifs de jeu et les serveurs de jeu, p. ex. en encryptant les données de jeu ou en authentifiant les joueurs
78.
GENETICALLY MODIFIED YEAST HOSTS AND METHODS FOR PRODUCING CITRAMALATE
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (USA)
THE TRUSTEES OF PRINCETON UNIVERSITY (USA)
Inventeur(s)
Yoshikuni, Yasuo
Wu, Zong-Yen
Hsieh, Ping-Hung
Dwaraknath, Sudharsan
Shao, Zengyi
Sun, Wan
Rabinowitz, Joshua D.
Shen, Yihui
Abrégé
The present invention provides for a genetically modified yeast host cell comprising a heterologous citramalate synthase, or multiple copies of a citramalate synthase, and knocked out or reduced in expression, or under conditional expression, for an endogenous or native pyruvate decarboxylase (PDC) gene; a method for constructing the genetically modified yeast host cell, and a method for producing citramalate using the genetically modified yeast host cell.
This disclosure relates to an unexpected discovery that antibiotics or purified diets significantly enhance phosphoinositide 3-kinase (PI3K) inhibition efficacy for cancer. Accordingly, this disclosure provides a novel method for treating a cancer using PI3K inhibitors in combination with antibiotics or purified diets.
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
A61K 31/43 - Composés contenant des systèmes cycliques thia-4 aza-1 bicyclo [3.2.0] heptane, c.-à-d. composés contenant un système cyclique de formule , p. ex. pénicillines, pénèmes
A61K 31/431 - Composés contenant des systèmes cycliques thia-4 aza-1 bicyclo [3.2.0] heptane, c.-à-d. composés contenant un système cyclique de formule , p. ex. pénicillines, pénèmes contenant d'autres systèmes hétérocycliques, p. ex. ticarcilline, azlocilline, oxacilline
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
According to various embodiments, a system for using magnetic reconnection to accelerate plasma is disclosed. The system includes a pair of electrodes including two concentric rings separated by an electrode gap and held at different electrostatic potential by applying a voltage to generate an inter-electrode electric field. The system further includes a plurality of magnetic coils configured to produce magnetic field lines that connect the pair of electrodes. The system additionally includes a gas injector configured to inject gas into the electrode gap, the injected gas being partially ionized by the inter-electrode electric field to generate a poloidal current that flows along open magnetic field lines across the electrode gap. A total Lorentz force causes oppositely directed magnetic field lines to be expanded around a region of the gas injector to further create an azimuthal current in the form of an axially elongated current sheet that is unstable such that the axially elongated current sheet reconnects and breaks into plasmoids.
Disclosed herein is an ultrafast, variable multi-focal technique using a laser (such as a picosecond laser or a femtosecond laser) to generate a pulsed laser beam, and a tunable acoustic gradient of index (TAG) lens ahead of an objective lens to achieve multi-focal laser scribing by shaping the pulsed laser beam pulse-by-pulse into a plurality of focal points along an axial axis of the laser beam at one or more selected positions without mechanically moving any optics or sample repositioning. The location of the focal points can be customized and even varied during processing.
B23K 26/067 - Division du faisceau en faisceaux multiples, p. ex. foyers multiples
B23K 26/046 - Focalisation automatique du faisceau laser
B23K 26/06 - Mise en forme du faisceau laser, p. ex. à l’aide de masques ou de foyers multiples
B23K 26/0622 - Mise en forme du faisceau laser, p. ex. à l’aide de masques ou de foyers multiples par commande directe du faisceau laser par impulsions de mise en forme
Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2− to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.
A61L 2/18 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances liquides
B01J 31/18 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination contenant de l'azote, du phosphore, de l'arsenic ou de l'antimoine
B01J 31/26 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant en outre des composés métalliques inorganiques non prévus dans les groupes
C02F 1/76 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par oxydation au moyen d'halogènes ou de composés halogénés
C02F 103/02 - Eau non contaminée, p. ex. pour l'alimentation industrielle en eau
Disclosed are systems and techniques for generating and steering laser beams onto atoms for performing locally addressed quantum gate operations. A system may include (i) a high-speed acousto-optic modulator (AOM) for producing a single input beam, (ii) a phase- only spatial light modulator (SLM) for imprinting a phase pattern on the single input beam, the phase pattern being chosen such that after a lens positioned after the SLM, the single input beam is divided into a pattern of secondary beams that correspond to the positions of the atoms or ions in a quantum computer, the lens after the SLM being positioned so the secondary beams are focused to form an image on a digital micromirror device (DMD) amplitude modulator, (iii) a compensation grating after the DMD, in the path of the secondary beams, and (iv) an objective lens after the compensation grating to image the secondary beams onto an atomic array.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
G02B 26/08 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la direction de la lumière
G02F 1/33 - Dispositifs de déflexion acousto-optique
Disclosed is a fast-response sensor system to measure a fluid vector in a plurality of dimensions. This system, known as ‘MAST’ (for MEMS Anemometry Sensing Tower), utilizes microelectromechanical (MEMS) hot-wire devices to produce a solid-state, lightweight, and robust flow sensor system suitable for, e.g., real-time wind estimation onboard a UAV. The MAST uses three through eighteen polygonally-arranged microscale flow sensors to determine the fluid's vector's direction and magnitude.
G01F 1/684 - Dispositions de structureMontage des éléments, p. ex. relativement à l'écoulement de fluide
G01F 1/69 - Dispositions de structureMontage des éléments, p. ex. relativement à l'écoulement de fluide utilisant un élément de chauffage, de refroidissement ou de détection d'un type particulier du type à résistance
G01F 1/696 - Circuits à cet effet, p. ex. débitmètres à courant constant
86.
ENHANCING AMMONIUM OXIDATION AND FLUOROCHEMICAL DEGRADATION WITH FERRIC IRON PHASE COMPRISING POLYMERIC COATINGS
Media are described herein for the degradation and/or remediation of ammonium, ammonium containing contaminants and/or fluorochemicals. A medium, in some embodiments, comprises an electron donor, an electron acceptor comprising iron particles having a polymeric coating, and a Feammox bacterium and/or one or more enzymes capable of oxidizing the electron donor coupled with reduction of Fe(III) of the iron particles to Fe(II). The electron donor, in some embodiments, comprises ammonium, an ammonium containing compound, and/or molecular hydrogen. The medium, in some embodiments, further comprises a fluorochemical component, and the Feammox bacterium and/or one or more enzymes exhibit reductive dehalogenase activity capable of fluorochemical degradation in conjunction with oxidation of the electron donor and electron transfer to the electron acceptor.
In one aspect, methods of depolymerization are described herein comprising providing a synthetic polymer including a hydroxylated aliphatic backbone or hydroxylated backbone segments, and homolytically activing O—H bonds of the hydroxyl groups. Homolytic activation induces the formation of alkoxy radical intermediates followed by C—C bond β-scission events breaking the polymer backbone into depolymerization products. In some embodiments, depolymerization products comprise alkyl radical intermediates reduced by hydrogen atom transfer. Moreover, in some embodiments, the depolymerization products are further reacted into difunctionalized products or comprise functionalities derived from the polymer structure. The difunctionalized products can subsequently be employed in polymerization processes for the production of additional synthetic polymers.
C07C 41/18 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther
C07C 1/22 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure à partir de composés organiques ne renfermant que des atomes d'oxygène en tant qu'hétéro-atomes par réduction
C07C 29/00 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons
C07C 37/055 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone d'un cycle aromatique à six chaînons par remplacement des groupes fonctionnels liés à un cycle aromatique à six chaînons par des groupes hydroxyle, p. ex. par hydrolyse par substitution d'un groupe lié au cycle par un oxygène, p. ex. d'un groupe éther
C07C 45/55 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par pyrolyse, réarrangement ou décomposition de composés oxo oligomères ou polymères
C07C 51/00 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides
C07C 253/00 - Préparation de nitriles d'acides carboxyliques
C08G 63/16 - Acides dicarboxyliques et composés dihydroxylés
C08G 69/00 - Composés macromoléculaires obtenus par des réactions créant une liaison amide carboxylique dans la chaîne principale de la macromolécule
88.
PROTEIN COMPLEXES FOR PROXIMITY-BASED LABELING OF INTRACELLULAR MICROENVIRONMENTS
Protein complexes and associated methods are described herein for proximity-based labeling of various intracellular or intercellular microenvironments. In some embodiments, a protein complex comprises a protein substrate having an ubiquitin E3 ligase associated therewith, wherein a transition metal complex is coupled to the protein substrate. In some embodiments, one or more intermediate molecular species, such as a small molecule and/or protein, reside between the ubiquitin E3 ligase and protein substrate.
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
C07D 213/22 - Composés hétérocycliques contenant des cycles à six chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle et avec au moins trois doubles liaisons entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques comportant trois liaisons doubles ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle contenant uniquement des atomes d'hydrogène et de carbone en plus de l'atome d'azote du cycle contenant au moins deux cycles pyridiques liés ensemble directement, p. ex. dipyridyle
89.
SYSTEM AND METHOD FOR PROBABILITY-BASED COMPLETION AND OPTIMIZATION OF PARTIAL SYSTEMS
Disclosed herein are techniques for completing and/or optimizing partial systems. The disclosed techniques may also check the integrity of the system. The disclosed techniques may also identify and correct error(s) after detecting an anomalous behavior. The technique may utilize a surrogate model to complete a partial system where only a subset of the component values and/or the system response are specified. When the system response exhibits multiple modes (e.g., a same response for different input combinations), the disclosed may determine the input combinations for several modes. Using past simulation logs, the disclosed techniques may include searching over any subset of the variable inputs to improve the performance of a reference solution. The disclosed technique may also provide an explanation of the decision it makes for the different use cases.
G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
G06N 3/047 - Réseaux probabilistes ou stochastiques
The Penn State University-College of Earth & Mineral Sciences (USA)
Inventeur(s)
Chi, Heng
Xu, Huijuan
Rodriguez, Alejandro
Houyou, Mohamed El Amine
Reinhart, Wesley
Molesky, Sean
Chao, Pengning
Abrégé
According to aspects of embodiments described herein, an optical computing device (100) comprises a plurality of input waveguides (101), a photonic meta-surface (103) in contact with the plurality of input waveguides, and a plurality of output waveguides (105) in contact with the transformational meta-surface. The optical computing device may be configured to perform a mathematical operation may be a matrix multiplication. A computer-implemented method (300) of designing an optical computing device includes a plurality of input waveguides, a photonic meta-surface, and a plurality of output waveguides, the method includes exciting each input waveguide one-by-one (303) and measuring the energy at the input region and the output region (305) to determine a contribution of the current input waveguide. The sum of contributions (307) of all input waveguides are compared to a target transformation (315) to determine a loss value used to update a set of design parameters (317).
G06E 1/04 - Dispositions pour traiter exclusivement des données numériques agissant sur l'ordre ou le contenu des données maniées pour effectuer des calculs en utilisant exclusivement une représentation numérique codée, p. ex. représentation binaire, ternaire, décimale
G02B 1/00 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques
G02B 27/00 - Systèmes ou appareils optiques non prévus dans aucun des groupes ,
Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.
Disclosed are systems and methods for combining quantum hardware and classical hardware to execute quantum algorithms. The systems may include a quantum processing unit. The systems may include a classical processing unit. The systems may include a storage medium operably containing instructions that, when executed by the system, cause the system to perform an embodiment of a disclosed method. The method may include receiving a plurality of subcircuit results from a plurality of subcircuits. Each subcircuit may be partitioned from an initial quantum circuit. The initial quantum circuit may be intended to be processed on the quantum processing unit. Each subcircuit may have fewer qubits than the initial quantum circuit. The method may include producing a quantum circuit result by combining the plurality of subcircuit results using tensor network contraction to post-process the plurality of results.
G06F 15/16 - Associations de plusieurs calculateurs numériques comportant chacun au moins une unité arithmétique, une unité programme et un registre, p. ex. pour le traitement simultané de plusieurs programmes
G06N 10/20 - Modèles d’informatique quantique, p. ex. circuits quantiques ou ordinateurs quantiques universels
G06N 10/60 - Algorithmes quantiques, p. ex. fondés sur l'optimisation quantique ou les transformées quantiques de Fourier ou de Hadamard
G06N 10/80 - Programmation quantique, p. ex. interfaces, langages ou boîtes à outils de développement logiciel pour la création ou la manipulation de programmes capables de fonctionner sur des ordinateurs quantiquesPlate-formes pour la simulation ou l’accès aux ordinateurs quantiques, p. ex. informatique quantique en nuage
Composites, systems and methods are described herein enabling the profiling of local microenvironments across various biomolecular condensates via proximity labeling. In some embodiments, a composite includes one or more biomolecular condensates comprising nucleic acids and/or functionally diverse proteins, and a transition metal catalyst coupled to the biomolecular condensate via interaction with at least one of the nucleic acids or functionally diverse proteins. Composites described herein, in some embodiments, are located in the intracellular environment.
Various embodiments comprise systems, methods, architectures, mechanisms, apparatus, and improvements thereof for the processing of text-based content such as from a collection of content items including unstructured and structured text of different formats and types so as to automatically derive therefrom an organized, trend-indicative representation of underlying topics/subtopics within the collection of content items.
Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.
Disclosed is a technique for transporting and arranging electronic components, using an optical system utilizing a laser beam to produce an optical trap in a fluid near a target site of a backplate, where a primary optical axis of the laser beam is perpendicular to the backplate and defines a longitudinal axis with an upwards direction pointing away from the backplate into the fluid, where a transverse direction lies in a plane parallel to the backplate. The technique may include providing a fluid comprising an electronic element mixed with a transport medium, the transport medium having a lower refractive index than the electronic element. The technique may include applying the fluid to a backplate surface as a film. The technique may include orienting and/or positioning the electronic element relative to the backplate by producing an optical trap near the target site. The element may then be attached to the backplate.
H01L 21/208 - Dépôt de matériaux semi-conducteurs sur un substrat, p. ex. croissance épitaxiale en utilisant un dépôt liquide
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
B82Y 40/00 - Fabrication ou traitement des nanostructures
H01L 29/06 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices
B82B 3/00 - Fabrication ou traitement des nanostructures par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles
97.
PROXIMITY-BASED LABELING OF SIALYLATED GLYCOPROTEINS
Systems and methods are described herein enabling the profiling of local microenvironments across the sialylated proteome via proximity labeling. In one aspect, conjugates are described herein having composition and electronic structure for generating reactive labeling intermediates in microenvironments of sialylated cell-surface glycoproteins. In some embodiments, a conjugate comprises a transition metal catalyst coupled to a cell surface glycoprotein. As described further herein, the transition metal catalyst can be coupled to the glycoprotein via a derivatized sialic acid linker.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p. ex. utilisation de bandes de papier indicateur
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
A two-step process is provided for forming large photonic single crystals of about 0.1 millimeter and greater via DNA coated colloidal particles. The two-step process generally include decoupling the nucleation and growth steps. In particular, DNA colloidal particles are partitioned in nanoliter droplets formed in a water in oil emulsion using microfluidics. Once a crystal nucleates within a droplet, depletion of particles occurs as the crystal grows inhibit formation of more crystals within the droplet. A small number of droplets containing these seed crystals are then mixed with droplets containing weak DNA coated colloidal particles. The emulsion is then broken and heated at a temperature effective to cause dissociation of the weak particles while the seeds remain stable. The system is further cooled at a temperature effective that the particles stably adhere to the seed crystals resulting in growth while inhibiting nucleation of new crystals.
C30B 7/08 - Croissance des monocristaux à partir de solutions en utilisant des solvants liquides à la température ordinaire, p. ex. à partir de solutions aqueuses par refroidissement de la solution
B01J 13/00 - Chimie des colloïdes, p. ex. production de substances colloïdales ou de leurs solutions, non prévue ailleursFabrication de microcapsules ou de microbilles
Provided herein are novel heterocyclic compounds, for example, compounds of Formula (IV-C). Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
C07D 215/227 - Atomes d'oxygène liés en position 2 ou 4 un seul atome d'oxygène qui est lié en position 2
C07D 215/50 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 4
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 491/048 - Systèmes condensés en ortho avec un seul atome d'oxygène comme hétéro-atome du cycle contenant de l'oxygène le cycle contenant de l'oxygène étant à cinq chaînons
Disclosed are criteria for a lattice matched, multilayer, organic crystal heterostructure. Current organic devices (e.g., photovoltaics, light emitting diodes, or transistors) rely on amorphous material despite superior charge transport properties of crystalline organic semiconductors. Achieving a fully crystalline device architecture requires growth of a molecular crystal atop a different one, or heteroepitaxy, and is particularly relevant in organic semiconductor devices that demand multiple layers of different molecules. This challenge is complicated when attempting to stack highly ordered layers needed for crystalline devices because strategies are needed to ensure that each layer grows crystalline. It is shown herein that lattice matching alone is not sufficient for successful organic heteroepitaxy deposited via physical vapor deposition. The process disclosed herein includes an additional criterion in which the lattice matched plane of the adlayer must also be the crystal face with the lowest surface energy. Application of this process leads to a full crystalline multilayer system in which there is perfect registry between the template layer and adlayer. Not only does this allow for the study of highly ordered interfaces, but it also opens the door to entirely crystalline device architectures, likely improving the efficiency over their amorphous counterparts.
