Abrégé

The invention provides a safe and stable plasmalogen, a formulation thereof, and a method for assessing presymptomatic dementia. More specifically, the invention comprises: a supplement or a foodstuff as a processed product for the mitigation, improvement, or prevention of dementia having as an active ingredient a plasmalogen with ω-3 highly unsaturated fatty acid (ω-3HUFA) bonds, etc.; a formulation for the treatment of neurodegenerative disease and/or mental illness; and a method for assessing presymptomatic dementia in a subject, where the subject is an adult who has not yet developed dementia (normal subject). The supplement or foodstuff comprises a plasmalogen-containing complex lipid, etc., that has been extracted and separated from the organs and specific sites in the living tissue of a chicken, and has a composition ratio unique to the living tissue in which a DHA-containing ω-3HUFA derivative is transferred to the living tissue of a chicken raised on feed containing the ω-3HUFA derivative.

Classes IPC  ?

• C07F 9/10 - Phosphatides, p. ex. lécithine
• A23K 20/158 - Acides grasGraissesProduits contenant des huiles ou des graisses
• A23L 33/28 - Substances d’origine animale, p. ex. gélatine ou collagène
• A61K 8/60 - SucresLeurs dérivés
• A61K 8/68 - Sphingolipides, p. ex. céramides, cérébrosides, gangliosides
• A61K 9/08 - Solutions
• A61K 9/107 - Émulsions
• A61K 31/683 - Diesters d'acide du phosphore avec deux composés hydroxyle, p. ex. phosphatidylinositols
• A61K 35/57 - OiseauxSubstances provenant des oiseaux, p. ex. œufs, plumes, blanc d’œuf, jaune d’œuf ou endothelium corneum gigeriae galli
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• A61P 25/18 - Antipsychotiques, c.-à-d. neuroleptiquesMédicaments pour le traitement de la manie ou de la schizophrénie
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• A61Q 19/00 - Préparations pour les soins de la peau
• C11B 11/00 - Obtention ou raffinage d'autres matières grasses, p. ex. lanoline ou cires

Abrégé

The purpose of the present invention is to provide a testing method and a biomarker, both of which enable the diagnosis of dementia (particularly Alzheimer-type dementia) in a simple manner, at low cost and safely. The present invention provides a testing method for determining whether or not a blood sample of interest is originated from a mammal having dementia, which comprises the steps of: (A) measuring the quantity of plasmalogen contained in erythrocytes contained in the blood sample; and (B) comparing (i) the quantity of plasmalogen contained in erythrocytes contained in the blood sample with (ii) the quantity of plasmalogen contained in erythrocytes from a normal mammal which is the same species as that of a mammal from which the blood sample is collected.

Classes IPC  ?

• G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
• G01N 30/86 - Analyse des signaux
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/92 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des lipides, p. ex. le cholestérol

Abrégé

The purpose of the present invention is to provide a novel method which has an effect of ameliorating central nervous system inflammation. Provided is a drug against central nervous system inflammation which comprises a plasmalogen. Particularly preferably provided is a drug against central nervous system inflammation which comprises a plasmalogen extracted from a biotissue (preferably an avian tissue) containing ethanolamine plasmalogen and choline plasmalogen.

Classes IPC  ?

• A61K 31/661 - Acides du phosphore ou leurs esters n'ayant pas de liaison P-C, p. ex. fosfosal, dichlorvos, malathion
• A61K 31/685 - Diesters d'acide du phosphore avec deux composés hydroxyle, p. ex. phosphatidylinositols un des composés hydroxylés ayant des atomes d'azote, p. ex. phosphatidylsérine, lécithine
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• A61P 25/16 - Antiparkinsoniens
• A61P 25/18 - Antipsychotiques, c.-à-d. neuroleptiquesMédicaments pour le traitement de la manie ou de la schizophrénie
• A61P 25/24 - Antidépresseurs
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

Provided is a method for running an electrothermal generator or steam generator to generate a steam heating medium from a nozzle, said steam heating medium being Aquagas or low-temperature superheated steam. In the provided method and device for generating a steam heating medium, either: Aquagas is generated by increasing the amount of water supplied such that, according to relation 1 or relation 2 specifying the flow rate of steam sprayed by the nozzle, the internal nozzle pressure is constant at a pressure greater than the saturated water vapor pressure at internal nozzle pressure setting temperatures; or low-temperature superheated steam is generated by decreasing the amount of water supplied such that the internal nozzle pressure does not exceed the saturated water vapor pressure at internal nozzle pressure setting temperatures.

Classes IPC  ?

• F22B 27/04 - Chaudières à vapeur instantanées ou du type flash avec des tubes d'eau
• A47J 27/16 - Récipients de cuisson pour hôtels, restaurants ou cantines chauffés à la vapeur
• F22B 1/28 - Méthodes de production de vapeur caractérisées par le genre de chauffage dans des chaudières chauffées électriquement
• F22G 1/10 - Surchauffe de la vapeur caractérisée par la méthode de chauffage avec dispositifs assurant la surchauffe de la vapeur par étranglements
• F24C 1/00 - Poêles ou fourneaux dans lesquels le combustible ou la source d'énergie n'est pas exclusivement un combustible solide ou d'un type couvert par un seul des groupes Poêles ou fourneaux dans lesquels le type de combustible ou d'énergie utilisé n'est pas spécifié

Abrégé

A method for manufacturing a processing raw material or a processed part is characterized in that a highly fresh raw material is heat-treated by a heating medium which is obtained by boiling water under pressure to generate steam or the mixture of steam and water and jetting the steam or the mixture from a nozzle into a semi-sealed heating chamber with a partial discharge path using a heating medium generating device which comprises a means for rotating a body to be heated in the directions of normal phase and reverse phase.

Classes IPC  ?

• A23L 1/01 - Méthodes générales de cuisson des aliments, p.ex. par rôtissage ou friture (méthodes spécifiques à des aliments particuliers, voir les sous-groupes appropriés);
• A23B 4/005 - Conservation par chauffage
• A23K 1/10 - à partir de viande, du poisson ou d'os; à partir des déchets de cuisine
• A23L 1/227 - contenant des acides aminés
• A23L 1/31 - Produits à base de viande; Farine de viande 
• A23L 1/315 - Produits à base de volaille, p.ex. saucisses à base de volaille
• A47J 27/14 - Récipients de cuisson pour hôtels, restaurants ou cantines
• A47J 37/04 - Appareils à rôtir avec supports mobiles pour les aliments ou avec instruments de chauffage mobilesBroches

Abrégé

Disclosed is a method for producing a dried material that retains an active ingredient inherent in a starting material or a ground product of the dried material, wherein the starting material comprises an isolated highly fresh tissue, part or organ of a domestic fowl or a mixture thereof.  The method comprises subjecting the starting material to the following steps (A) to (C) and optionally step (D) in this order: (A) a finely cutting/grinding step; (B) a heating step; (C) a drying step; and (D) a grinding step, wherein the step (B) comprises carrying out a heating treatment in a semi-sealed space which has a low oxygen gas atmosphere, an ambient pressure and a temperature ranging from 95 to 120°C and is formed by a gas-liquid mixed medium composed of fine water droplets and water vapor.

Classes IPC  ?

• A23L 1/315 - Produits à base de volaille, p.ex. saucisses à base de volaille
• A23J 7/00 - Compositions à base de phosphatides pour l'alimentation, p. ex. lécithine
• A23K 1/10 - à partir de viande, du poisson ou d'os; à partir des déchets de cuisine
• A23L 1/29 - Modification de la qualité nutritive des aliments; Produits diététiques ( A23L 1/09 a priorité;substituts diététiques du sel A23L 1/22)
• A61K 8/68 - Sphingolipides, p. ex. céramides, cérébrosides, gangliosides
• A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées

Abrégé

Disclosed is a method for producing a highly pure sphingomyelin and a highly pure plasmalogen-type glycerophospholipid from a biological material in high yields by simple manipulations. Specifically disclosed is a method for producing highly pure phospholipids, which comprises the following steps (A) to (E): (A) subjecting a dried total lipid content extracted from a biological material to an extraction treatment with a specific mixed solvent to separate the dried total lipid content into an insoluble fraction and a soluble fraction; (B) washing the insoluble fraction obtained in the step (A) with a specific mixed solvent to produce a crude sphingomyelin; (C) washing the soluble fraction obtained in the step (A) with a water-soluble ketone solvent to produce a crude plasmalogen-type glycerophospholipid; (D) reacting the crude sphingomyelin obtained in the step (B) with an enzyme to produce a sphingomyelin having a purity of 90% or higher; and (E) reacting the crude plasmalogen-type glycerophospholipid obtained in the step (C) with an enzyme to produce a plasmalogen-type glycerophospholipid having a purity of 40% or higher.

Classes IPC  ?

• C11B 11/00 - Obtention ou raffinage d'autres matières grasses, p. ex. lanoline ou cires
• A23J 7/00 - Compositions à base de phosphatides pour l'alimentation, p. ex. lécithine
• C11B 1/10 - Production des graisses ou huiles à partir de matières premières par extraction
• C11B 3/00 - Raffinage des graisses ou huiles
• C11B 3/02 - Raffinage des graisses ou huiles par réaction chimique

Abrégé

Disclosed is a method for producing a phospholipid-containing functional material or a high-purity plasmalogen-type glycerophospholipid from a poultry breast meat by a simple manipulation and in high yield. Specifically disclosed are: a method for producing a phospholipid-containing functional material by transforming the shape of a poultry breast meat by at least one process selected from the following processes (a) to (c): (a) a process of mincing the poultry breast meat in a low-temperature and low-oxygen atmosphere; (b) a process of pasting the poultry breast meat together with an emulsifying/dispersing agent at a low temperature; and (c) a process of powderizing the poultry breast meat by drying at a low temperature; and a method for producing a plasmalogen-type glycerophospholipid, which comprises the following steps (A) to (C): (A) extracting the entire fat material from a powder of a poultry breast meat and drying the extracted fat material; (B) extracting the dried entire fat material with a solvent to separate into an insoluble fraction and a soluble fraction; and (C) extracting the soluble fraction with a solvent to separate and collect the insoluble fraction.

Classes IPC  ?

• C11B 11/00 - Obtention ou raffinage d'autres matières grasses, p. ex. lanoline ou cires
• C11B 1/00 - Production des graisses ou huiles à partir de matières premières

Abrégé

A process for producing a functional material by deoiling/defatting poultry epidermis via a heating treatment to thereby concentrate and pasteurize a human type sphingomyelin and a plasmalogen type glycerophospholipid contained in the epidermis, characterized in that the heating treatment comprises: (A) the step wherein hot water and/or steam having been heated to 100oC or higher is continuously jetted into a heating chamber that is a semi-closed space having been heated to the same temperature or higher to thereby generate water droplets and hot and wet steam; (B) the step wherein the atmosphere in the above-described heating chamber is replaced by the water droplets and hot and wet steam as described above so as to fill the chamber with a gas component (gaseous water) which has a relative humidity of 95% or higher and an oxygen concentration of 0.2% by volume or less and is maintained within a temperature range of from 100 to 115oC; (C) the step wherein 100%-moistened steam is jetted to the above-described gaseous water so as to stably form a composite heating medium which comprises the hot water, water droplets and steam; and (D) the step wherein the poultry epidermis is subjected to the heat treatment by conducting continuous amplitude heating of a temperature difference of at least 10oC with the above-described composite heating medium in an atmosphere at a temperature of 100 to 115oC and an oxygen concentration of 0.2% by volume or less.

Classes IPC  ?

• A23J 7/00 - Compositions à base de phosphatides pour l'alimentation, p. ex. lécithine
• A23L 1/30 - contenant des additifs (A23L 1/308 a priorité);;
• A61K 8/55 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du phosphore
• A61K 8/68 - Sphingolipides, p. ex. céramides, cérébrosides, gangliosides
• A61Q 19/00 - Préparations pour les soins de la peau

Abrégé

A process for producing sphingomyelin and plasmalogen-form glycerophospholipid, characterized by comprising:(A) a step in which all lipids are extracted from a chicken-skin powder and dried; (B) a step in which the dried all lipids obtained in the step (A) are extracted with a solvent mixture of an aliphatic hydrocarbon solvent and a water-soluble ketone solvent to separate the lipids into an insoluble part consisting mainly of sphingomyelin and a soluble part; (C) a step in which the insoluble part consisting mainly of sphingomyelin obtained in the step (B) is extracted with a solvent mixture of water and a water-soluble ketone solvent to remove the non-lipid ingredients from the soluble part; and (D) a step in which the soluble part obtained in the step (B) is dried and then extracted with a water-soluble ketone solvent to separate and recover an insoluble part consisting mainly of a plasmalogen-form glycerophospholipid. Thus, high-purity sphingomyelin, especially human sphingomyelin, and a plasmalogen-form glycerophospholipid can be produced in a satisfactory yield from the skin of a chicken by a simple operation.

Classes IPC  ?

• C11B 1/10 - Production des graisses ou huiles à partir de matières premières par extraction