A sample analysis system analyzes a sample. A panel design generates a sample preparation specification. A preparation instrument prepares a sample using the sample preparation specification to generate a prepared sample. A sample analyzer analyzes the prepared sample. A validator validates an operation of the sample analysis system. A sample analysis system has a transfer station that controls the movement of a probe with respect to a reaction plate. A probe wash module is also disclosed.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
A system for acquiring the image data of refrigerated materials is disclosed. The system includes a material management unit with an imaging system. The material management unit further includes a refrigerated chamber in which material vials are stored. The imaging system includes a window positioned on the side of the material management unit that separates an interior space of the refrigerated chamber from an exterior space of the material management unit. The imaging system further includes a camera positioned in the exterior space that captures image data through the window. The window is heated along its sides by a heating element, which functions to prevent condensation from forming on the surface of the window.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
3.
ANTIBODY CONCENTRATION MEASUREMENT, TITER MODULE, AND LIQUID STORAGE MODULE FOR CELL ANALYSIS SYSTEM
A system for measuring a concentration of an antibody in a sample includes a polarizer holder retaining first and second detection polarizers. The first detection polarizer restricting passage of light fluoresced from within a container to a first direction. The second detection polarizer restricting passage of light fluoresced from within the container to a second direction. The second direction is perpendicular to the first direction. The system includes a detector for measuring the light fluoresced in the first direction and the light fluoresced in the second direction. The system rotates the polarizer holder about an axis of rotation in alternating directions causing alternate placement of the first and second detection polarizers in an optical path of the light fluoresced from within the container.
The present disclosure provides systems, methods, and kits to directly calibrate fluorescence sensitivity in a flow cytometer using lipid enveloped droplets comprising first, second, and third known concentrations of analytes encapsulated in lipid enveloped droplets, and wherein the analytes have a fluorescent dye. In embodiments, the analytes encapsulated in lipid enveloped droplets comprise a fluorescent dye, a fluorescent dye conjugated to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), a hydrophilic partner that can prevent the analyte from crossing the lipid envelop of the droplet, protein, antibody, antibody fragment, nanobody, or a combination thereof.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
5.
SYSTEMS AND METHODS FOR PANEL DESIGN IN FLOW CYTOMETRY
Embodiments of the present invention encompass systems and methods for determining detection limits for various antibody-dye conjugates for flow cytometry. Exemplary techniques involve a linear superpositioning approach of spillover-induced enlargements of normally distributed measurement errors.
G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines
G01N 15/10 - Recherche de particules individuelles
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
A sorting flow cytometer receives a current alignment of a light beam, determines a difference between the current alignment of the light beam and a target alignment of the light beam, and calculates one or more voltage values based on the difference between the current alignment and the target alignment. The sorting flow cytometer uses the voltage values to adjust a position of at least one of a first alignment actuator extending in a first axial direction and a second alignment actuator extending in a axial second direction to reduce the difference between the current alignment of the light beam and the target alignment of the light beam.
G01N 15/10 - Recherche de particules individuelles
G01N 15/149 - Techniques de recherche optique, p. ex. cytométrie en flux spécialement adaptées au tri des particules, p. ex. selon leur taille ou leurs propriétés
7.
Integrated Sample Processing System with Multiple Detection Capability
An integrated sample processing system including an analyzer and a mass spectrometer is disclosed. The integrated sample processing system can perform multiple different types of detection, thereby providing improved flexibility and better accuracy in processing samples. The detection systems in the sample processing system may include an optical detection system and a mass spectrometer.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 27/624 - Spectrométrie de mobilité ionique différentielle [DMS]Spectrométrie de mobilité ionique à haut champ asymétrique [FAIMS]
H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails
Described herein are systems, devices, and methods allowing for a subset of images to be used to establish a population count for biological material (e.g., blood cells).
Errors in an analyzer fluidics system may be detected using systems and methods which involve obtaining a plurality of pressure measurements while a vacuum is being applied to a tube used to remove fluid from a container. These measurements may then be provided to a classification module, and the classification module may determine a status output as either a normal status output, or one of a set of error status outputs.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
35 - Publicité; Affaires commerciales
37 - Services de construction; extraction minière; installation et réparation
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Chemical preparations and reagents, for scientific and
research use; reagents, assays, and chemical preparations
all for scientific, research, and laboratory purposes and
analysis; chemical preparations for scientific purposes,
other than for medical or veterinary purposes; chemical
reagents, other than for medical or veterinary purposes;
chemical substances for analyses in laboratories, other than
for medical or veterinary purposes; reagents for use in
genetic research; genomic reagents, for scientific and
research use; flow cytometry reagents, for scientific and
research use; reagents and chemical preparations used for
the identification and characterization of cells, for
scientific and research use; reagents for use in particle
size analysis and characterization, for scientific and
research use; panels of reagents, for scientific and
research use; laser excitable dyes, for scientific and
research use; fixable viability dyes, for scientific and
research use; dyes and stains for the identification and
characterization of cells, for scientific and research use;
chemical reagents containing magnetic beads for the
isolation, purification, and extraction of DNA and RNA, for
scientific and research use; nucleic acid isolation and
purification kits consisting primarily of reagents and
magnetic beads, for scientific and research use; lysing
reagents, for scientific and research use; chemiluminescent
reagents, for scientific and research use. Chemical preparations and reagents, for medical diagnostic
purposes; reagents and chemical preparations, for medical
diagnostic purposes; panels of reagents, for medical
purposes; medical assays for testing of body fluids;
chemicals and reagents for in vitro medical diagnostic use;
reagents, assays, and chemical preparations for testing of
biological specimens, for medical diagnostic purposes;
reagents for use in flow cytometry, for medical purposes;
lysing reagents, for medical purposes; biological tissue,
namely, animal cells, tissues, and blood, for medical
purposes; medical diagnostic reagents and solutions, namely,
diluents; antibiotics in test containers, canisters, panels
and microtitre plates, for medical use; chemiluminescent
reagents, for medical use. Analytical apparatus and instruments for analyzing
biological samples and bodily fluids, for laboratory use and
replacement parts and fittings therefor and downloadable and
recorded operating system software sold therewith;
laboratory apparatus and instruments for analyzing
biological samples and bodily fluids, for scientific or
research purposes and downloadable and recorded operating
system software for use in connection with the apparatus and
instruments; downloadable and recorded software for use in
operating, monitoring, and controlling laboratory and
diagnostic apparatus and instruments and analyzing data
generated by the apparatus and instruments; laboratory
instruments for the analysis of biological samples and
bodily fluids, for scientific and research purposes;
laboratory robots; laboratory sample preparation instruments
for scientific purposes; automated sample handling
equipment, for scientific and research use; automated liquid
handling instruments, for scientific and research use;
bioreactors for laboratory use; automated laboratory
equipment for cell culturing, namely, bioreactors and cell
culture plates; air particle counters; multi-parameter
biological cell sorter instruments, for scientific and
research use; laboratory centrifuges; centrifuge rotors
being parts of laboratory centrifuges; flow cytometers for
scientific, laboratory, and general research uses; total
organic carbon analyzers, for scientific and research
purposes; instruments for particle sizing, counting, and
analysis; microparticle processor apparatus and instruments,
for scientific and research purposes; laboratory apparatus
and instruments for nucleic acid cleanup and purification;
laboratory equipment for scientific purposes, namely, cell
analyzers; computer hardware and downloadable and recorded
computer operating software for use with laboratory and
diagnostic instruments, namely, for use in providing
automation of laboratory processes, control and monitoring
of laboratory instruments, instrument operation, sample
management, connectivity, data analysis, and data
management; downloadable and recorded software for technical
support and advice, troubleshooting, diagnosis, repair, and
maintenance of laboratory equipment and diagnostic
instruments; recorded and downloadable software for use with
laboratory instruments, namely, for use in monitoring and
controlling the operation of the instrument, setting up
experiment protocols, sample management, data collection,
data management, and data analysis; recorded and
downloadable software for collecting, managing, storing,
analyzing, and reporting biological information, and for
managing projects, laboratory workflows, and data, for use
for scientific, diagnostic, and research purposes; computer
system comprised primarily of computer hardware and recorded
and downloadable computer software used for collecting,
managing, interpreting, and analyzing data from laboratory
instruments; downloadable and recorded data analysis
software for laboratory, scientific, research, and medical
use; recorded and downloadable computer software using
artificial intelligence for managing and analyzing data from
laboratory and diagnostic instruments; downloadable and
recorded laboratory middleware software for providing an
interface between laboratory, physician, hospital, and
medical information systems and laboratory instruments;
downloadable and recorded software for clinical decision
support; recorded and downloadable software for sample
processing and storage, sample sorting, routing, sample
scheduling and sample analysis for use with medical and
laboratory diagnostic systems; laboratory consumables for
scientific and research use, namely, laboratory centrifuge
buckets and adapters, automated lab positioners, laboratory
specimen tubes, laboratory specimen bottles, test tube racks
for laboratory specimen handling and storage, laboratory
specimen tube rack inserts, test tube rack holders,
laboratory storage devices in the nature of cap mats,
laboratory plate seal rollers and seals therefor, well
plates, reagent and solvent reservoirs, pipette tips,
probes, laboratory cassettes for specimen processing and
storage, cell culture flask adapters, disposable plastic
bioreactors for cell culturing, well plates, microfluidic
plates, lids for well plates, lids for microfluidic plates,
reagent bottles sold empty, reagent holding trays, funnels,
droppers, dropper caps and waste bags specially adapted for
holding laboratory waste, and rehydrator and inoculator
devices for rehydrating and inoculating multiple wells with
inoculum liquids; downloadable and recorded operating system
software for apparatus and instruments for the analysis of
biological samples and bodily fluids, for medical diagnostic
use; computer hardware and recorded and downloadable
computer operating system software for medical diagnostic
analyzers for the analysis of biological samples and bodily
fluids, for medical purposes. Apparatus and instruments for the analysis of biological
samples and bodily fluids, for medical diagnostic use and
replacement parts and fittings therefor; clinical laboratory
analyzers for the analysis of biological samples and bodily
fluids, for medical purposes; apparatus and instruments for
medical diagnostic use, namely, analyzers for the analysis
of biological samples and bodily fluids; instrument for the
analysis of biological samples and bodily fluids, for
medical purposes; medical diagnostic analyzers for the
analysis of biological samples and bodily fluids, for
medical purposes; instruments for use in automated microbial
identification and susceptibility testing, for medical
purposes; urine analyzers, for medical purposes; chemistry
analyzers, for medical purposes, namely, medical laboratory
devices used to calculate the concentration of certain
substances within samples of bodily fluids; protein
chemistry analyzers, for medical purposes, namely, medical
laboratory devices used to calculate the concentration of
protein within samples of bodily fluid; immunoassay
apparatus and instruments, namely, immunoassay analyzers for
identifying and detecting the concentration of specific
substances in a sample, for medical purposes; hematology
analyzers, for medical purposes; automated blood banking
analyzers; automated sample handling and testing equipment
for medical diagnostic use; sample preparation device, for
medical diagnostic uses; flow cytometers, for medical
diagnostic uses. Online retail store services featuring laboratory apparatus
and instruments and their parts, fittings, and accessories
therefor and software sold therewith, reagents and chemical
preparations, and laboratory consumables; business
consulting and advisory services for laboratories, clinics,
healthcare providers and related businesses to improve
laboratory processes, quality, performance, productivity,
efficiency, reduce waste and reduce costs; business
consulting services, namely, evaluation of laboratory
workflows and processes to improve quality, performance, and
efficiency; business efficiency advice for laboratories,
clinics, healthcare providers and related businesses. Repair and maintenance of laboratory equipment and
diagnostic instruments; technical support services in the
nature of troubleshooting being repair of problems with
laboratory apparatus and instruments; technical support
services in the nature of troubleshooting of computer
hardware problems with laboratory apparatus and instruments. Providing training in the use of laboratory equipment and
diagnostic instruments; training for laboratories, clinics,
healthcare providers and related businesses in the fields of
laboratory equipment and diagnostic instruments to improve
laboratory quality, performance, and efficiency; conducting
workshops and seminars for laboratories, clinics, healthcare
providers and related businesses in the fields of laboratory
equipment and diagnostic instruments to improve laboratory
quality, performance, and efficiency. Scientific research; scientific analysis of data in the
field of laboratory testing; laboratory analysis in the
field of medicine, namely, analysis of chemical markers for
medical research purposes; scientific consulting services in
the field of laboratory operation and automation; consulting
services in the field of laboratory testing, diagnostics,
and laboratory processes and standards; scientific research
in the field of laboratory equipment and instruments;
product development for laboratory and diagnostic equipment;
technical support services in the nature of troubleshooting
of computer software problems with laboratory apparatus and
instruments; technological advice relating to laboratory
apparatus and instruments; Software as a service (SAAS)
services featuring software for uploading, managing,
analyzing, sharing, and preserving data related to
scientific research and medical diagnostic testing; software
as a service (SAAS) services featuring software for
automating and optimizing workflow operations, for workflow
management for laboratories, and electronic data interchange
(EDI); providing temporary use of non-downloadable medical
analysis software for use in patients diagnostics; providing
temporary use of non-downloadable cloud-based software for
assisting hospitals and medical laboratories in clinical,
financial reimbursement decisions, inventory management,
sample scheduling, and laboratory management and regulatory
reporting; software as a service (SAAS) services featuring
software for technical support and advice, troubleshooting,
diagnosis, repair, and maintenance of laboratory equipment
and diagnostic instruments; software as a service (SAAS)
services featuring software for collecting, managing,
storing, analyzing, and reporting biological information,
and for managing projects, laboratory workflows, and data,
for use for scientific, diagnostic, and research purposes;
software as a service (SAAS) services featuring software for
data analysis for laboratory, scientific, research, and
medical use; software as a service (SAAS) services featuring
artificial intelligence software for managing and analyzing
data from laboratory and diagnostic instruments; software as
a service (SAAS) services featuring laboratory middleware
software for providing an interface between laboratory,
physician, hospital, and medical information systems and
laboratory instruments; software as a service (SAAS)
services featuring software for clinical decision support;
development of medical diagnostic tests for others. Medical information in the field of in vitro diagnostic
testing; providing healthcare information in the field of in
vitro diagnostic testing; providing medical in vitro
diagnostic testing information; medical analysis services
for in vitro diagnostic tests; providing medical information
to medical professionals in the form of biomedical data in
the field of in vitro diagnostic testing; providing
personalized healthcare and medical information in the form
of biomedical data in the field of in vitro diagnostic
testing; medical diagnostic reporting services in the field
of in vitro diagnostic testing; laboratory analysis in the
field of medicine, namely, analysis of chemical markers for
medical diagnostic purposes.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
35 - Publicité; Affaires commerciales
37 - Services de construction; extraction minière; installation et réparation
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Chemical preparations and reagents, for scientific and
research use; reagents, assays, and chemical preparations
all for scientific, research, and laboratory purposes and
analysis; chemical preparations for scientific purposes,
other than for medical or veterinary purposes; chemical
reagents, other than for medical or veterinary purposes;
chemical substances for analyses in laboratories, other than
for medical or veterinary purposes; reagents for use in
genetic research; genomic reagents, for scientific and
research use; flow cytometry reagents, for scientific and
research use; reagents and chemical preparations used for
the identification and characterization of cells, for
scientific and research use; reagents for use in particle
size analysis and characterization, for scientific and
research use; panels of reagents, for scientific and
research use; laser excitable dyes, for scientific and
research use; fixable viability dyes, for scientific and
research use; dyes and stains for the identification and
characterization of cells, for scientific and research use;
chemical reagents containing magnetic beads for the
isolation, purification, and extraction of DNA and RNA, for
scientific and research use; nucleic acid isolation and
purification kits consisting primarily of reagents and
magnetic beads, for scientific and research use; lysing
reagents, for scientific and research use; chemiluminescent
reagents, for scientific and research use. Chemical preparations and reagents, for medical diagnostic
purposes; reagents and chemical preparations, for medical
diagnostic purposes; panels of reagents, for medical
purposes; medical assays for testing of body fluids;
chemicals and reagents for in vitro medical diagnostic use;
reagents, assays, and chemical preparations for testing of
biological specimens, for medical diagnostic purposes;
reagents for use in flow cytometry, for medical purposes;
lysing reagents, for medical purposes; biological tissue,
namely, animal cells, tissues, and blood, for medical
purposes; medical diagnostic reagents and solutions, namely,
diluents; antibiotics in test containers, canisters, panels
and microtitre plates, for medical use; chemiluminescent
reagents, for medical use. Analytical apparatus and instruments for analyzing
biological samples and bodily fluids, for laboratory use and
replacement parts and fittings therefor and downloadable and
recorded operating system software sold therewith;
laboratory apparatus and instruments for analyzing
biological samples and bodily fluids, for scientific or
research purposes and downloadable and recorded operating
system software for use in connection with the apparatus and
instruments; downloadable and recorded software for use in
operating, monitoring, and controlling laboratory and
diagnostic apparatus and instruments and analyzing data
generated by the apparatus and instruments; laboratory
instruments for the analysis of biological samples and
bodily fluids, for scientific and research purposes;
laboratory robots; laboratory sample preparation instruments
for scientific purposes; automated sample handling
equipment, for scientific and research use; automated liquid
handling instruments, for scientific and research use;
bioreactors for laboratory use; automated laboratory
equipment for cell culturing, namely, bioreactors and cell
culture plates; air particle counters; multi-parameter
biological cell sorter instruments, for scientific and
research use; laboratory centrifuges; centrifuge rotors
being parts of laboratory centrifuges; flow cytometers for
scientific, laboratory, and general research uses; total
organic carbon analyzers, for scientific and research
purposes; instruments for particle sizing, counting, and
analysis; microparticle processor apparatus and instruments,
for scientific and research purposes; laboratory apparatus
and instruments for nucleic acid cleanup and purification;
laboratory equipment for scientific purposes, namely, cell
analyzers; computer hardware and downloadable and recorded
computer operating software for use with laboratory and
diagnostic instruments, namely, for use in providing
automation of laboratory processes, control and monitoring
of laboratory instruments, instrument operation, sample
management, connectivity, data analysis, and data
management; downloadable and recorded software for technical
support and advice, troubleshooting, diagnosis, repair, and
maintenance of laboratory equipment and diagnostic
instruments; recorded and downloadable software for use with
laboratory instruments, namely, for use in monitoring and
controlling the operation of the instrument, setting up
experiment protocols, sample management, data collection,
data management, and data analysis; recorded and
downloadable software for collecting, managing, storing,
analyzing, and reporting biological information, and for
managing projects, laboratory workflows, and data, for use
for scientific, diagnostic, and research purposes; computer
system comprised primarily of computer hardware and recorded
and downloadable computer software used for collecting,
managing, interpreting, and analyzing data from laboratory
instruments; downloadable and recorded data analysis
software for laboratory, scientific, research, and medical
use; recorded and downloadable computer software using
artificial intelligence for managing and analyzing data from
laboratory and diagnostic instruments; downloadable and
recorded laboratory middleware software for providing an
interface between laboratory, physician, hospital, and
medical information systems and laboratory instruments;
downloadable and recorded software for clinical decision
support; recorded and downloadable software for sample
processing and storage, sample sorting, routing, sample
scheduling and sample analysis for use with medical and
laboratory diagnostic systems; laboratory consumables for
scientific and research use, namely, laboratory centrifuge
buckets and adapters, automated lab positioners, laboratory
specimen tubes, laboratory specimen bottles, test tube racks
for laboratory specimen handling and storage, laboratory
specimen tube rack inserts, test tube rack holders,
laboratory storage devices in the nature of cap mats,
laboratory plate seal rollers and seals therefor, well
plates, reagent and solvent reservoirs, pipette tips,
probes, laboratory cassettes for specimen processing and
storage, cell culture flask adapters, disposable plastic
bioreactors for cell culturing, well plates, microfluidic
plates, lids for well plates, lids for microfluidic plates,
reagent bottles sold empty, reagent holding trays, funnels,
droppers, dropper caps and waste bags specially adapted for
holding laboratory waste, and rehydrator and inoculator
devices for rehydrating and inoculating multiple wells with
inoculum liquids; downloadable and recorded operating system
software for apparatus and instruments for the analysis of
biological samples and bodily fluids, for medical diagnostic
use; computer hardware and recorded and downloadable
computer operating system software for medical diagnostic
analyzers for the analysis of biological samples and bodily
fluids, for medical purposes. Apparatus and instruments for the analysis of biological
samples and bodily fluids, for medical diagnostic use and
replacement parts and fittings therefor; clinical laboratory
analyzers for the analysis of biological samples and bodily
fluids, for medical purposes; apparatus and instruments for
medical diagnostic use, namely, analyzers for the analysis
of biological samples and bodily fluids; instrument for the
analysis of biological samples and bodily fluids, for
medical purposes; medical diagnostic analyzers for the
analysis of biological samples and bodily fluids, for
medical purposes; instruments for use in automated microbial
identification and susceptibility testing, for medical
purposes; urine analyzers, for medical purposes; chemistry
analyzers, for medical purposes, namely, medical laboratory
devices used to calculate the concentration of certain
substances within samples of bodily fluids; protein
chemistry analyzers, for medical purposes, namely, medical
laboratory devices used to calculate the concentration of
protein within samples of bodily fluid; immunoassay
apparatus and instruments, namely, immunoassay analyzers for
identifying and detecting the concentration of specific
substances in a sample, for medical purposes; hematology
analyzers, for medical purposes; automated blood banking
analyzers; automated sample handling and testing equipment
for medical diagnostic use; sample preparation device, for
medical diagnostic uses; flow cytometers, for medical
diagnostic uses. Online retail store services featuring laboratory apparatus
and instruments and their parts, fittings, and accessories
therefor and software sold therewith, reagents and chemical
preparations, and laboratory consumables; business
consulting and advisory services for laboratories, clinics,
healthcare providers and related businesses to improve
laboratory processes, quality, performance, productivity,
efficiency, reduce waste and reduce costs; business
consulting services, namely, evaluation of laboratory
workflows and processes to improve quality, performance, and
efficiency; business efficiency advice for laboratories,
clinics, healthcare providers and related businesses. Repair and maintenance of laboratory equipment and
diagnostic instruments; technical support services in the
nature of troubleshooting being repair of problems with
laboratory apparatus and instruments; technical support
services in the nature of troubleshooting of computer
hardware problems with laboratory apparatus and instruments. Providing training in the use of laboratory equipment and
diagnostic instruments; training for laboratories, clinics,
healthcare providers and related businesses in the fields of
laboratory equipment and diagnostic instruments to improve
laboratory quality, performance, and efficiency; conducting
workshops and seminars for laboratories, clinics, healthcare
providers and related businesses in the fields of laboratory
equipment and diagnostic instruments to improve laboratory
quality, performance, and efficiency. Scientific research; scientific analysis of data in the
field of laboratory testing; laboratory analysis in the
field of medicine, namely, analysis of chemical markers for
medical research purposes; scientific consulting services in
the field of laboratory operation and automation; consulting
services in the field of laboratory testing, diagnostics,
and laboratory processes and standards; scientific research
in the field of laboratory equipment and instruments;
product development for laboratory and diagnostic equipment;
technical support services in the nature of troubleshooting
of computer software problems with laboratory apparatus and
instruments; technological advice relating to laboratory
apparatus and instruments; Software as a service (SAAS)
services featuring software for uploading, managing,
analyzing, sharing, and preserving data related to
scientific research and medical diagnostic testing; software
as a service (SAAS) services featuring software for
automating and optimizing workflow operations, for workflow
management for laboratories, and electronic data interchange
(EDI); providing temporary use of non-downloadable medical
analysis software for use in patients diagnostics; providing
temporary use of non-downloadable cloud-based software for
assisting hospitals and medical laboratories in clinical,
financial reimbursement decisions, inventory management,
sample scheduling, and laboratory management and regulatory
reporting; software as a service (SAAS) services featuring
software for technical support and advice, troubleshooting,
diagnosis, repair, and maintenance of laboratory equipment
and diagnostic instruments; software as a service (SAAS)
services featuring software for collecting, managing,
storing, analyzing, and reporting biological information,
and for managing projects, laboratory workflows, and data,
for use for scientific, diagnostic, and research purposes;
software as a service (SAAS) services featuring software for
data analysis for laboratory, scientific, research, and
medical use; software as a service (SAAS) services featuring
artificial intelligence software for managing and analyzing
data from laboratory and diagnostic instruments; software as
a service (SAAS) services featuring laboratory middleware
software for providing an interface between laboratory,
physician, hospital, and medical information systems and
laboratory instruments; software as a service (SAAS)
services featuring software for clinical decision support;
development of medical diagnostic tests for others. Medical information in the field of in vitro diagnostic
testing; providing healthcare information in the field of in
vitro diagnostic testing; providing medical in vitro
diagnostic testing information; medical analysis services
for in vitro diagnostic tests; providing medical information
to medical professionals in the form of biomedical data in
the field of in vitro diagnostic testing; providing
personalized healthcare and medical information in the form
of biomedical data in the field of in vitro diagnostic
testing; medical diagnostic reporting services in the field
of in vitro diagnostic testing; laboratory analysis in the
field of medicine, namely, analysis of chemical markers for
medical diagnostic purposes.
12.
METHOD OF DETERMINING SEPSIS IN THE PRESENCE OF BLAST FLAGGING
Embodiments of the present disclosure may allow for an efficient and accurate way or system to assess whether an individual has sepsis, including an individual who may exhibit symptoms or clinical criteria similar to inflammation. Embodiments include using a laboratory test that may be routinely ordered. Embodiments of the present invention may allow for the diagnosis of sepsis even when some cells show an abnormal size. Often, when white blood cells show a likelihood of an abnormal size, a “blast flag” in a system is triggered to warn a user that the sample may warrant further analysis. Unexpectedly, the diagnosis of sepsis status using standard deviation of monocyte volume may be more accurate when considering whether a blast flag has been triggered. Based on the sepsis status, treatment may be started quickly, thereby preventing complications, including organ failure and death, of not treating sepsis fast enough.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 15/1031 - Recherche de particules individuelles en mesurant des effets électriques ou magnétiques
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
13.
ASYNCHRONOUS TRAINING FOR CLASSIFICATION IN FLOW CYTOMETRY
Systems, devices, and method for asynchronous training for classification of cellular subsets for flow cytometry. A training file is identified for training a classifier. A gate associated with the training file is received for training the classifier and a model for training the classifier is received. The classifier training begins and, concurrent with training of the classifier: flow cytometry files are classified and an accuracy of the classifier is monitored. A determination is made whether the gate should be adjusted based on the accuracy and a determination is made whether training of the classifier is complete.
Systems and methods of flushing and washing a titer container. The container is drained, by a pump in fluid communication with an access port of the container via a multiport valve, of at least one of a biological or control sample comprising a first volume. The container is flushed, by the pump, with flushing agent comprising a second volume via the access port and the multiport valve. The container is filled, by the pump, with a cleaning agent comprising a third volume and rinsed, after a cleaning period, by the pump, with flushing agent comprising the second volume.
The disclosed flow cytometer includes a wavelength division multiplexer (WDM). The WDM includes an extended light source providing light that forms an object, a collimating optical element that captures light from the extended light source and projects a magnified image of the object as a first light beam, and a first focusing optical element configured to focus the first light beam to a size smaller than the object of the extended light source to a first semiconductor detector. The disclosed flow cytometer further includes a composite microscope objective to direct light emitted by a particle in a flow channel in a viewing zone of the composite microscope to the extended light source, a fluidic system and a peristaltic pump configured to supply liquid sheath and liquid sample to the flow channel, and a laser diode system to illuminate the particle in the flow channel.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G02B 6/293 - Moyens de couplage optique ayant des bus de données, c.-à-d. plusieurs guides d'ondes interconnectés et assurant un système bidirectionnel par nature en mélangeant et divisant les signaux avec des moyens de sélection de la longueur d'onde
G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
G02B 27/00 - Systèmes ou appareils optiques non prévus dans aucun des groupes ,
G01N 15/10 - Recherche de particules individuelles
16.
AUTOMATED PIPETTE TIP ORGANIZING FOR FLUID HANDLING SYSTEMS
A method for automatically defragmenting pipette tips in a tip tray during the performance of a procedure defined by a protocol stored in memory of a fluid handling system, the method comprising determining locations of open receptacles in the tip tray where pipette tips are absent, determining locations of filled receptacles in the tip tray where pipette tips are present, and using the fluid handling system to move pipette tips from filled receptacles to open receptacles to complete strings of filled receptacles in the tip tray.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
A visual analysis system may be automatically focused (or the focus of such a system may be automatically corrected) by subjecting one or more images captured by such a system to a multi-layer analysis. In such an analysis, a cell boundary may be identified in an input image based on the lightness value of the pixels of the input image. Based on the identified cell boundary, a predicted nominal focus value is determined which can provide a focusing distance (e.g., a distance between the focal plane of a camera used when an image was captured and the actual focal plane for an in-focus image). This focusing distance may then be used to (re) focus a camera or for other purposes (e.g., generating an alert).
G06T 7/194 - DécoupageDétection de bords impliquant une segmentation premier plan-arrière-plan
G06V 10/60 - Extraction de caractéristiques d’images ou de vidéos relative aux propriétés luminescentes, p. ex. utilisant un modèle de réflectance ou d’éclairage
18.
APPARATUS, METHOD AND SYSTEM FOR ASSIGNING PROCESSING STEPS TO A LABORATORY AUTOMATON SYSTEM
A computer-implemented method is provided. The method comprises: accessing, by a first computing device, sample-processing data, wherein the sample-processing data comprise information indicative of a set of procedures to be carried out on a biological sample, wherein each procedure comprises one or more actions; obtaining, by the first computing device, ALS1 state data, wherein the ALS1 state data comprise information indicative of a state of a first automated laboratory system-ALS1; obtaining, by the first computing device, ALS2 operation data, wherein the ALS2 operation data comprise information indicative of an ALS2 set of actions of at least a first procedure, wherein the ALS2 set of actions either has been carried out or is scheduled to be carried out by a second automated laboratory system-ALS2-on the biological sample; generating, by the first computing device, ALS1 processing data by using the sample-processing data, the ALS1 state data and the ALS2 operation data, wherein the ALS1 processing data comprise information indicative of an ALS1 set of actions of at least a second procedure of the sets of procedures; and initiating, by the first computing device, the generation of an ALS1 route plan for the first automated laboratory system, the ALS1 route plan being based on the ALS1 processing data.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
Automatic substance preparation and evaluation systems and methods are provided for preparing and evaluating a fluidic substance, such as e.g. a sample with bodily fluid, in a container and/or in a dispense tip. The systems and methods can detect volumes, evaluate integrities, and check particle concentrations in the container and/or the dispense tip.
G06T 7/62 - Analyse des attributs géométriques de la superficie, du périmètre, du diamètre ou du volume
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
G06V 10/50 - Extraction de caractéristiques d’images ou de vidéos en effectuant des opérations dans des blocs d’imagesExtraction de caractéristiques d’images ou de vidéos en utilisant des histogrammes, p. ex. l’histogramme de gradient orienté [HoG]Extraction de caractéristiques d’images ou de vidéos en utilisant l’addition des valeurs d’intensité d’imageAnalyse de projection
G06V 10/56 - Extraction de caractéristiques d’images ou de vidéos relative à la couleur
A detection system of a flow cytometer and a method of using the detection system are provided. The detection system comprises a light-emitting unit; a lens assembly comprising a focussing lens; and a light collection unit configured to collect light scattered from a nanoparticle at the interrogation point. The method comprises using the lens assembly to focus a laser beam emitted by the light-emitting unit at an interrogation point. A profile of the incident laser beam incident on the focussing lens has a first dimension parallel to the trajectory of the nanoparticle. A first ratio of a first diameter of the focussing lens to the first dimension of the incident laser beam is higher than a first threshold such that light fringes of the focussed laser beam at the interrogation point are suppressed. An intensity of the focused laser beam at the interrogation point is higher than a second threshold.
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
G01N 15/10 - Recherche de particules individuelles
The present invention provides water-soluble tetrahydropyrene based fluorescent polymers, water-soluble tetrahydropyrene based tandem fluorescent polymers, water-soluble fluorescent polymer complexes, and their use in methods for detecting an analyte in a sample.
The present disclosure provides a method (400) of evaluating a fluidic substance (10) having particles (11). The method (400) comprises capturing a reference image (202) of at least a portion of a container (102) that is in an empty state; determining a reference grayscale value (V1) of at least a portion of the reference image (202); aspirating a volume of the fluidic substance (10) into the container (102); capturing a test image (252) of the container (102) containing the aspirated volume of the fluidic substance (10); determining a test grayscale value (V2) of at least a portion of the test image (252); calibrating a universal calibration curve (56) relating particle concentration and grayscale value based on the reference and test grayscale values (V1, V2); and determining a particle concentration (P1) in the fluidic substance (10) based on the test grayscale value (V2) and the calibrated universal calibration curve (60).
A method, a computer program, a computer-readable medium and a computer system for providing a state of a clinical test carried out on a biological sample via a laboratory instrument are provided. The clinical test comprises a plurality of processing steps, The method comprises determining, after starting the clinical test, an expected completion time for the clinical test based on one or more expected durations and one or more actual durations, wherein each processing step of the plurality of processing steps that has not been completed has a respective expected duration of the one or more expected durations and each processing step of the plurality of processing steps that has been completed has a respective actual duration of the one or more actual durations. The method further comprises displaying a warning when at least one warning condition of one or more warning conditions are met, wherein the one or more warning conditions comprise at least one warning condition on the expected completion date.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
A method of characterizing particles in flow cytometry includes determining a first pulse width value of a particle using a first technique. The method includes determining a second pulse width value of the particle using a second technique. The method further includes comparing the first and second pulse width values, and characterizing the particle as a concatenated particle when a difference between the first and second pulse width values exceeds a threshold.
Summarizing the invention, a method is provided. The method comprises: instructing a laboratory instrument comprising an aspirating/dispensing device to aliquot a drawing volume of a biological sample contained in a primary sample container; determining that an error has occurred, wherein the error affects at least one of: the laboratory instrument, a state of the biological sample, and a state of a secondary sample container configured to receive the drawing volume; selecting, based on at least one of a type of the error and a time point at which it is determined that the error has occurred, an action from a plurality of actions to be performed by the laboratory instrument, wherein the plurality of actions comprise a reinsertion action that comprises dispensing the drawing volume to the primary sample container; and instructing the laboratory instrument to perform the selected action.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
28.
INFECTION DETECTION AND DIFFERENTIATION SYSTEMS AND METHODS
Embodiments may include an automated method for evaluating an infection status associated with a blood sample obtained from an individual. Methods may include determining, using a first module, a white blood cell concentration associated with the blood sample. In addition, methods may include determining, using a second module, a monocyte volume measure associated with the blood sample. Methods may include evaluating, using a data processing module, the infection status associated with the blood sample. The data processing module may include a processor and a computer readable medium. The computer readable medium may be programmed with a computer application. This computer application, when executed by the processor, may cause the processor to calculate a parameter using a function comprising the white blood cell concentration and the monocyte volume measure. The computer application may also cause the processor to evaluate the infection status associated with the blood sample based on the parameter.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
29.
SYSTEM AND METHOD FOR ALIQUOTING A BIOLOGICAL SAMPLE
Summarizing the invention, a patient-sample-handling system is provided. The patient- sample-handling system comprises: an aliquoter unit comprising a dispenser, wherein the dispenser is configured to aspirate a sample volume from a primary sample container and to dispense at least part of the sample volume into a secondary sample container; and a labelling unit configured to affix a label to the secondary sample container; wherein the labelling unit is configured to accommodate the secondary sample container when the dispenser dispenses the at least part of the sample volume into the secondary sample container.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
30.
SYSTEM AND METHODS FOR SURFACE ENHANCED RAMAN SPECTROSCOPY
The presently claimed and described technology provides systems and methods for determining concentration of an analyte of interest using Surface Enhanced Raman Spectroscopy (SERS). An automated SERS system can include a body for accepting a substrate, a fluid handling system, a light source, and a detector that collects and detects Raman scattered light.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
31.
PROTEIN FREE SOLUTION FOR STABILIZING IMMUNOASSAY CALIBRATORS
Disclosed and claimed are compositions containing a calibrator and a stabilizer, wherein the stabilizer includes Diethylaminoethyl- ("DEAE") dextran; D-Sorbitol, wherein the D-Sorbitol and DEAE-dextran are in a weight ratio from about 1:1 to about 5:2, a buffer; and a non-ionic surfactant; wherein the stabilizer is essentially free of bovine serum albumin; and wherein the calibrator is stabilized under frozen storage conditions, and remains stable when thawed and kept at temperatures of from about 2°C to about 10°C. Also disclosed are methods of use of the claimed compositions and kits comprising the claimed compositions.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/96 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir un étalon de contrôle du sang ou du sérum
A focusing distance (e.g., a distance between a focal plane of a camera used when n image was captured and the actual focal plane for an in-focus image) in a visual analysis system may be determined by subjecting one or more images captured by such a system to a multi-layer analysis. In such an analysis, an input may be subjected to one or more convolution filters, and the ultimate result of such convolution may be provided to a dense layer which can provide the focusing distance. This focusing distance may then be used to (re)focus a camera or for other purposes (e.g., generating an alert).
H04N 23/67 - Commande de la mise au point basée sur les signaux électroniques du capteur d'image
G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines
A biological analysis system includes a probe. The probe is configured to dispense a biological sample into a first chamber. The system also includes a pump. The pump is configured to convey a first delivery of diluent to the first chamber for mixing with the biological sample to produce a sample mixture, aspirate a portion of the sample mixture from the first chamber, and convey the portion of the sample mixture to a second chamber. A method of analyzing a biological sample includes conveying a diluent to a first chamber via a first pump, dispensing a blood sample into the first chamber via a probe to produce a sample mixture, and conveying a portion of the sample mixture from the first chamber to a second chamber via the first pump.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G01N 1/14 - Dispositifs d'aspiration, p. ex. pompesDispositifs d'éjection
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
A sample preparation instrument for dispensing processed samples into output tubes is described. The instrument scans specimen-panel assignment barcodes. The instrument associates the output tubes with a panel selected for a specimen. The instrument operates a transfer station to dispense processed samples from the specimen into the output tubes based on the association of the output tubes with the panel.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 1/14 - Dispositifs d'aspiration, p. ex. pompesDispositifs d'éjection
A biological analysis system includes a flow generator, a flowcell, a first flow path, and a second flow path. The flow generator is configured to provide a sheath fluid. The flowcell is configured to receive a biological sample. The first flow path is in fluid communication with the flow generator and configured to receive a first portion of the sheath fluid from the flow generator. The first flow path is configured to convey the biological sample using the first portion to the flowcell at a first flow rate. The second flow path is in fluid communication with the flow generator and configured to receive a second portion of the sheath fluid from the flow generator. The second flow path is configured to convey the second portion to the flowcell at a second flow rate. The second flow rate is different than the first flow rate.
A method of fluorescence polarization is disclosed for measuring a concentration of an antibody in a sample. The method includes performing a measurement cycle measuring a first set of sampling phases of fluorescence polarized in a first polarization direction and a second set of sampling phases of the fluorescence polarized in a second polarization direction. At least one sampling phase of the fluorescence polarized in the second polarization direction occurs between sampling phases of the fluorescence polarized in the first polarization direction. The method includes calculating a first value of the first set of sampling phases and calculating a second value of the second set of sampling phases. The method includes determining the concentration of the antibody based on a function of the first and second values.
A computer-implemented method of determining an acute myocardial infarction. AMI, type indicator, is described. The method comprises obtaining, at a computing device, subject data associated with a subject suspected of having AMI, the subject data comprising a) at least one Troponin value indicative of a Troponin concentration determined for the subject, b) at least one Albumin value indicative of an Albumin concentration determined for the subject, and c) at least one Eosinophil value indicative of an Eosinophil concentration determined for the subject. The method further comprises computing, based on the obtained subject data with the computing device, at least one AMI type indicator indicative of one or both a likelihood for the subject to have a type 1 AMI and a likelihood for the subject to have a type 2 AMI.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
38.
APPARATUS, METHOD AND SYSTEM FOR PROCESSING SAMPLE TUBES
Summarizing the invention, an apparatus configured to interact with a tube rack, the tube rack comprising a data storage element, is provided. The apparatus comprises: —a data reading unit configured to read first data from a sample tube when the sample tube is arranged at a reading position with respect to the data reading unit; —a detection unit comprising at least one sensor configured to detect the presence of the sample tube in the tube rack if the tube rack is at a detection position with respect to the at least one sensor; —a computing unit configured to write second data to the data storage element when the at least one sensor detects the presence of the sample tube in the tube rack.
A method for performing a function check of a fluid handling system can comprise dispensing a first reference dose of a fluid into a reference container using a first fluid dispenser, measuring a first fluid height of the first reference dose in the reference container with a fluid level sensing system of the fluid handling system, and changing a status of the fluid handling system based on the first measured first fluid height. Robotic fluid handling system can comprise controllers and computer readable memory configured to execute the methods described herein.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
The present disclosure provides novel benzothienopyrrole (Bt)-cyanine(Cy) fluorescent compounds, water-soluble BtCy fluorescent dyes, water-soluble BtCy binding partner conjugates, and tandem dyes thereof. The BtCy fluorescent compounds, conjugates, and tandem dyes can be excited using yellow, orange, red, NIR, or IR wavelengths. The fluorescent dyes may be conjugated to a binding partner for detection of target analytes in biological samples and are suitable for use in flow cytometry analyses. Those dyes have the following generic formula wherein Ar1 is selected from the group consisting of a substituted or unsubstituted benzene, benzene derivative, monocyclic aryl group, polycyclic aryl group, monocyclic heteroaryl group, and polycyclic heteroaryl group.
C09B 23/06 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH trois groupes CH, p. ex. carbocyanines
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
C09B 23/01 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique
C09B 57/00 - Autres colorants synthétiques de structure connue
C09B 69/00 - Colorants non prévus par un seul groupe de la présente sous-classe
Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
C08G 61/10 - Composés macromoléculaires contenant uniquement des atomes de carbone dans la chaîne principale de la molécule, p. ex. polyxylylènes uniquement des atomes de carbone aromatiques, p. ex. polyphénylènes
C09B 69/10 - Colorants polymèresProduits de réactions de colorants avec des monomères ou avec des composés macromoléculaires
G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
G01N 33/542 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p. ex. extinction de fluorescence
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
Service for a machine such as a laboratory instrument can be facilitated by capture of images showing the field of view of a user of the machine, and modification of those images to remove confidential information. Modified images can then be provided to service technicians so that the service technicians can have visual information that would allow them to more effectively communicate and interact with the machines' users.
The present disclosure provides systems, methods, and kits to improve the characterization, including the quality control, of a flow cytometer. In an embodiment, a system for characterization of a flow cytometer comprises a first standard particle reagent, wherein the first standard particle reagent comprises a first particle mixture and a second standard particle reagent, wherein the second standard particle reagent comprises a second particle mixture wherein the particles have a fluorescent dye.
Summarizing the invention. a computer-implemented method is provided. The method comprises: accessing, by a first computing device, test data and instrument data, wherein: the test data comprise information specifying at least one clinical test to be carried out on a biological sample of a subject, the instrument data comprise information specifying a state and/or a configuration of a set of laboratory instruments, and at least one laboratory instrument of the set of laboratory instruments is configured to carry out the at least one clinical test; generating, by the first computing device, sample-collecting data by using at least the test data and the instrument data, wherein: the sample-collecting data comprise at least one of a sample volume requirement and a sample container requirement, the sample volume requirement comprises one or more suitability constraints on a volume of the biological sample, and the sample container requirement comprises one or more constraints on a container in which the biological sample Is to be held; providing, by the first computing device, the sample-collecting data to a phlebotomy agent.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
A workflow and associated system for controlling pH is described that allows for real-time pH adjustment in parallel culture wells of a microplate. For example, a biological process control system comprised of a pH measurement system, a controller, and a pH adjustment system implements a closed control loop, where a pH of a culture well measured by the pH measurement system is compared to a predetermined pH for the culture well, and, if there is a deviation, a pH adjustment system adjusts the pH in the culture well to correct the deviation as the system continues on to measure, evaluate, and adjust, if needed, remaining microplate culture wells. Therefore, by performing per-well pH evaluation and adjustment in real-time upon receiving the measured pH rather than waiting until pH of all culture wells are measured, the measured pH used as a basis for pH adjustment is a current, accurate measurement.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
46.
ASSESSMENT OF RISK FOR MAJOR ADVERSE CARDIAC EVENT
A computer-implemented method of determining a major adverse cardiovascular event, risk of MACE, in a patient, is provided. The method comprises receiving, with a computing device, subject value data for the patient, the subject value data including (i) at least one troponin value, (ii) at least one demographic value, and (iii) at least one of a value for prior history of cardiac disease, a value of prior history of renal disease, an erythrocyte mean corpuscular hemoglobin value and an electrolyte value. Further, the method comprises evaluating, with the computing device, the received subject value data of the patient based on a reference dataset indicative of reference subject values associated with one or more reference patients, wherein the reference dataset is indicative of reference subject values including (i) at least one troponin value, (ii) at least one demographic value, and (iii) a value for prior history of cardiac disease. Further, the risk of MACE is determined based on the evaluation.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
47.
METHOD FOR ARCHIVING A SAMPLE TUBE, METHOD FOR RETRIEVING A SAMPLE AND TUBE RACK
An aspect of the present invention relates to an archiving method for archiving in a storage, in particular in a cold storage, at least one sample tube containing a biological sample using at least one tube rack, the method comprising the following steps: receiving, by a computing system, a request for archiving the at least one sample tube, placing the at least one sample tube in at least one receptacle of the at least one tube rack to receive the at least one sample tube, recording and/or updating, in a memory unit of the computing system, sample-tube-storage-data including sample tube data and/or tube rack data and/or storage data, storing the at least one tube rack in the storage. Further aspects relate to a retrieving method and a tube rack.
Summarizing the invention, a method is provided. The method comprises: accessing, by a computing device, test order data, wherein the test order data comprise information specifying a set of clinical tests to be carried out by a laboratory instrument on a biological sample contained in a sample container, wherein each clinical test is associated with a set of retain conditions so that the sample container is associated with one or more sets of retain conditions; determining, by the computing device, whether at least one set of retain conditions associated with the sample container is met; and if at least one set of retain conditions associated with the sample container is met, causing, by the computing device, the sample container to be retained in the laboratory instrument; wherein each set of retain conditions associated with a respective clinical test comprises a condition that one or more rules require that one or more supplementary tests shall be carried out whenever one or more supplementary test conditions on the respective clinical test are met.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
49.
Display screen or portion thereof with graphical user interface
A system for dispensing a density gradient in a container is described. The system pumps a volume of sample particles and a density modifier into a mixing chamber in fluid communication with a proximal end of a probe. The mixing chamber mixes the sample particles and the density modifier together to at least partially form the density gradient. The system dispenses the density gradient through a distal end of the probe into the container. The density gradient varies in density between first and second ends, and at least a portion of the density gradient between the first and second ends includes a dispensed volume of the sample particles.
Medical laboratory apparatus and instruments for the analysis of biological samples and bodily fluids, for medical diagnostic use and their replacement parts and fittings therefor and downloadable and recorded operating system software sold as a unit therewith; clinical medical laboratory analyzers for the analysis of biological samples and bodily fluids, for medical diagnostic purposes; apparatus and instruments for medical diagnostic use, namely, laboratory analyzers for the analysis of biological samples and bodily fluids; medical laboratory instrument for the analysis of biological samples and bodily fluids, for medical diagnostic purposes; medical diagnostic laboratory analyzers for the analysis of biological samples and bodily fluids, for medical purposes with computer hardware and downloadable and recorded computer operating system software for use therewith, sold as a unit; medical laboratory instruments for use in automated microbial identification and susceptibility testing, for medical diagnostic purposes; medical laboratory urine analyzers, for medical diagnostic purposes; chemistry analyzers, for medical diagnostic purposes, namely, medical laboratory devices used to calculate the concentration of certain substances within samples of bodily fluids; protein chemistry analyzers, for medical diagnostic purposes, namely, medical laboratory devices used to calculate the concentration of protein within samples of bodily fluid; immunoassay apparatus and instruments, namely, medical laboratory immunoassay analyzers for identifying and detecting the concentration of specific substances in a sample, for medical diagnostic purposes; medical laboratory hematology analyzers, for medical diagnostic purposes; medical laboratory automated blood banking analyzers; medical laboratory automated sample handling and testing equipment for medical diagnostic use; medical laboratory sample preparation device, for medical diagnostic uses
52.
CONSUMABLES CONTAINER LOADING/UNLOADING SYSTEM AND METHOD OF LOADING/UNLOADING CONSUMABLES CONTAINERS FOR AUTOMATED ANALYZER
A system (100) is provided for an automated analyzer (10) having an analyzer arrangement (20) configured to consume liquid consumables (30L) when in an active mode (12). The liquid consumables (30L) are delivered to the automated analyzer (10) via consumables containers (30). The system (100) comprises a storage magazine (120) configured to removably hold at least one of the consumables containers (30), a tray (150) configured to manually receive one or more of the consumables containers (30) from an operator at least while the analyzer arrangement (20) is in the active mode (12), and a transfer system (250) configured to transfer one or more of the consumables containers (30) at least between the tray (150) and the storage magazine (120). The transfer system (250) transfers one or more of the consumables containers (30) to or from the storage magazine (120) at least while the tray (150) manually receives one or more of the consumables containers (30) from the operator.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
The presently claimed and described technology provides an apparatus (500, 1000A, 1000B) configured to adjustably position a focal location (14) of a first instrument (12) of a first body (10, 20, 60) with respect to a target location (44, 54) of a second instrument (42, 42H, 42U, 52) of a second body (40, 50). The apparatus further includes a third body (30), a first joint (210), and a second joint (310). The first joint is configured to adjustably linearly position the first body with respect to the third body along a first axis (A2) and thereby perform a first adjustment and is further configured to adjustably rotatably position the first body with respect to the third body about the first axis (A2) and thereby perform a second adjustment. The second joint is configured to adjustably linearly position the second body with respect to the third body along a second axis (A3) and thereby perform a third adjustment and further configured to adjustably rotatably position the second body with respect to the third body about the second axis (A3) and thereby perform a fourth adjustment. Each of the first, second, third, and/or fourth adjustments are performed independently of each other and may have zero backlash. Additional third axis (A1, A1A, A1B) linear and/or rotational adjustment mechanism(s) may be added. In certain embodiments, the first, second, and/or third axes intersect each other at a point (P).
The present disclosure provides UV-absorbing polymer dyes and methods for detecting an analyte in a sample by using a binding partner conjugated to a UV-absorbing polymer dye. Compositions comprising UV-absorbing polymer dyes, UV-absorbing tandem dyes, or quenched UV polymer dyes are provided.
C09B 69/10 - Colorants polymèresProduits de réactions de colorants avec des monomères ou avec des composés macromoléculaires
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
55.
ANALOG LIGHT MEASURING AND PHOTON COUNTING IN CHEMILUMINESCENCE MEASUREMENTS
A luminometer (400) includes a light detector (630) configured to sense photons (135). The luminometer (400) includes an analog circuit (915a) configured to provide an analog signal (965) based on the photons (135) emitted from assay reactions over a time period and a counter circuit (915b) configured to provide a photon count (970) based on the photons (135) emitted from the assay reactions over the time period. The luminometer (400) includes a luminometer controller (905) configured to, in response to an analog signal value of the analog signal (965) being greater than a predetermined value, determine and report a measurement value of the photons (135) emitted from the assay reactions over the time period based on the analog signal value of the analog signal (965) and a linear function (1010). Optionally, the linear function (1010) is derived from a relationship between the analog signal (965) and the photon count (970).
G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
56.
SAMPLE TUBE, SAMPLE TUBE CLOSING DEVICE AND METHOD FOR CLOSING A SAMPLE TUBE
The present invention relates to a sample tube (10), a sample tube closing device for closing a sample tube (10) and a method of closing a sample tube (10), the sample tube (10) comprising:
a bottom portion (30),
a tubular portion (20), and an opening portion (40),
wherein the opening portion (40) comprises a foldable structure (41) configured to be foldable in a predetermined manner from an open state into a closed state.
A method of reducing quality problems associated with patient sample collection and delivery is provided. It is possible that the method can provide a chain of custody process to better track a sample from the initial point of sample collection to the final point of sample testing. Such a method can also include providing an alert to indicate a potential problem with the quality of the diagnostic test result when a measured parameter exceeds a threshold.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B01L 9/06 - Supports de tubes à essaiPorte-tubes à essai
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
A high sensitivity flow cell for a flow cytometer including a cuvette. The cuvette having a body including a body height, a body length, and a body width; and a flow channel passing centrally through the body along the body height and having an inner dimension through which a sample flows and intersects with an excitation beam at an interrogation point, wherein the inner dimension has a particular aspect ratio.
A computer-implemented method of determining, for a patient, a risk of developing sepsis is described. The method comprises obtaining, at a computing device, a set of patient data indicative of at least one of: a patient age value, a patient heart rate value, a patient respiratory rate value, a patient diastolic blood pressure value, a patient systolic blood pressure value, a patient temperature value, and a patient oxygen saturation value; and at least one value of a Monocyte Distribution Width (MDW) of the patient. Further, the method comprises determining, based on processing the obtained set of patient data with the computing device, at least one sepsis score indicative of the risk for a sepsis event occurring at the patient.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
60.
THRESHOLD LOGIC FOR FLOW CYTOMETRY WAVEFORM ANALYSIS
A flow cytometry system for analyzing particles. The flow cytometry system detects waveform data from the particles passing through an interrogation zone. The waveform data is detected by the system without thresholding. The system receives a playback selection including a logical operator for determining when to begin thresholding the waveform data after detection. The system analyzes the waveform data based on the playback selection.
A flow cytometer adjusts one or more control variables of a light source, a fluidic system, and an optical system based on a first set of values. The flow cytometer acquires a sequence of waveform data from particles streaming through a light beam in an interrogation zone under the first set of values for the one or more control variables. The flow cytometer adjusts the one or more control variables at predetermined intervals to acquire additional sequences of the waveform data using different sets of values for the one or more control variables.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
A flow cytometry system for analyzing a fluid stream of particles. The system collects waveform data without thresholding radiated light detected from particles passing through a light beam in an interrogation zone. The system identifies doublets from the waveform data. For each doublet identified from the waveform data, the system separates doublet waveforms into individual waveforms. The system analyzes the individual waveforms separated for each doublet and categorizes the doublets based on the analysis of the individual waveforms.
A method of automating startup of a bioreactor and normalizing seeding of cell cultures by counting a number of viable cells in a cell sample by a cell health module. A desired starting density of cells is received and a volume of media and a volume of the cell sample are each determined, based on the number of cells in the cell sample, to be combined to yield a predetermined density of cells in a bioreactor. The media and cell sample are combined to yield a cell culture by supplying the volume of media to the bioreactor and supplying the volume of the cell sample to the bioreactor.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
The present disclosure provides compositions, methods, and kits to improve the quality control of a flow cytometer by using fluorospheres encapsulated with at least one dye having an infrared fluorescence emission and at least one dye having at least one fluorescence emission between 355 nm and 800 nm. In an embodiment, a composition is a suspension for quality control of a flow cytometer comprising fluorospheres, wherein the suspension of fluorospheres include individual fluorospheres having an infrared fluorescence emission greater than 800 nm when excited with an infrared laser and at least one fluorescence emission between 355 nm and 800 nm when excited at a wavelength of less than 800 nm, at least one surfactant, and at least one stabilizer or preservative.
A gassing lid assembly enables gas-tight sealing of sample containers in general, also referred to as microplates in some embodiments, with simultaneous guided access for the pipetting unit of a dispensing/pipetting robot, also referred to as a pipettor. The component enables both gas-tight sealing and guided access for the pipetting robot. The gassing lid serves a number of purposes at the same time and provides the following advantages in a non-limiting fashion: a gas tight seal, robot integration without a gassing lid, robot integration with a gassing lid, a sealing mechanism, and anaerobic transport. Reducing the volume above reservoirs of a sample container (e.g., the volume above wells of a microplate) is advantageous in that it reduces the safety risk of high concentrations of gases such as oxygen.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
68.
OBLIQUE ILLUMINATION OF SAMPLES IMAGED USING FLOW THROUGH MICROSCOPY
Techniques for oblique illumination of samples in microscopy imaging are presented. The sample may be obliquely illuminated by directing light from a light emitter toward a sample at an oblique angle, rather than directly along the optical axis of an imaging device. The oblique angle may be created using an aperture mask with an aperture that is not coaxial with the optical axis of the imaging device. The oblique angle may also be created using a light emitter and collector lens that are not coaxial with the optical axis of the imaging device, such that the condenser lens directs the light toward the sample. Images obtained using the oblique illumination provide improved contrast of translucent particles and may have an embossed, three-dimensional appearance.
G01N 15/0227 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’imagerieRecherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’holographie
G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
A method for density-based separation of lipid based nanoparticles by centrifugation includes receiving a container having a solution and lipid based nanoparticles. The method includes applying a centrifugal force to the container to cause the lipid based nanoparticles to displace and form at least one grouping within the container. The method includes measuring the position of the at least one detectable grouping of lipid based nanoparticles.
Disclosed herein are various embodiments related to a blood cell classification system, which may include a plurality of general classifiers and specialized classifiers. The system being configured to determine, using the plurality of general classifiers, a predicted cell label for an imaged blood cell. The plurality of predicted cell labels are then provided to a decision aggregator which determines whether the predicted cell labels fulfil one or more compatibility criteria. Responsive to determining that the predicted cell label fulfils the one or more compatibility criteria the decision aggregator assigns the consolidated cell label based on one or more of the predicted cell labels provided by the plurality of classifiers Alternatively, responsive to determining that the predicted cell label does not fulfill the one or more compatibility criteria the decision aggregator provides the cell labels to a specialized classifier configured to assign the consolidated cell label.
G06V 10/762 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant le regroupement, p. ex. de visages similaires sur les réseaux sociaux
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
G06V 10/80 - Fusion, c.-à-d. combinaison des données de diverses sources au niveau du capteur, du prétraitement, de l’extraction des caractéristiques ou de la classification
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
G01N 15/10 - Recherche de particules individuelles
Cell classification may be performed using a system which receives a set of images comprising representations for a plurality of cells, and which performs various acts of each of those cells. Those acts may include determining imaging parameters for each of those cells, generating a cluster assignment for each of those cells, and providing a type for each of those cells based on the cluster assignments.
G06F 18/23213 - Techniques non hiérarchiques en utilisant les statistiques ou l'optimisation des fonctions, p. ex. modélisation des fonctions de densité de probabilité avec un nombre fixe de partitions, p. ex. K-moyennes
G06V 10/762 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant le regroupement, p. ex. de visages similaires sur les réseaux sociaux
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
A detection system for analyzing particles is described. The detection system detects radiated light as a particle passes through a light beam and generates a waveform as a digital representation of the radiated light detected from the particle. The detection system performs a waveform regression analysis on the waveform to obtain coefficients for characterizing the waveform and assigns one or more characteristics to the particle based on the coefficients.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G09B 23/22 - Modèles à usage scientifique, médical ou mathématique, p. ex. dispositif en vraie grandeur pour la démonstration pour la physique pour l'optique
G01N 15/0205 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques
G01N 15/10 - Recherche de particules individuelles
A computer-implemented method of determining, for a patient, a risk of developing a major adverse cardiovascular event, MACE, is described. The method comprises obtaining, at a computing device, a set of patient data indicative of a) at least one troponin value of the patient, b) an age of the patient, and c) at least one of a respiratory rate value of the patient and an anion gap value of the patient. The method further comprises determining, based on processing the obtained set of patient data with the computing device, at least one MACE score indicative of the risk for a MACE event occurring at the patient.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
Automatic substance preparation and evaluation systems and methods are provided for preparing and evaluating a fluidic substance, such as e.g. a sample with bodily fluid, in a container and/or in a dispense tip. The systems and methods can detect volumes, evaluate integrities, and check particle concentrations in the container and/or the dispense tip.
G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
G06T 7/62 - Analyse des attributs géométriques de la superficie, du périmètre, du diamètre ou du volume
G06V 10/50 - Extraction de caractéristiques d’images ou de vidéos en effectuant des opérations dans des blocs d’imagesExtraction de caractéristiques d’images ou de vidéos en utilisant des histogrammes, p. ex. l’histogramme de gradient orienté [HoG]Extraction de caractéristiques d’images ou de vidéos en utilisant l’addition des valeurs d’intensité d’imageAnalyse de projection
Certain types of automated medical analysis equipment are used to analyze blood or other fluids. The equipment may thus use various diluents or reagents that allow the blood or other fluids to be run through the analysis equipment for analysis and data collection. Disclosed is a diluent preparation module that combines purified water and reagent concentrate for use by this equipment. Also disclosed is a diluent preparation unit that combines more than one diluent preparation modules for redundancy and back-up purposes. Also disclosed are systems for supplying the Diluent prepared by the diluent preparation module or diluent preparation unit to one or more analytic instruments.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
A sample analysis system may comprise a flowcell, a fluidics system, an image capture device, and a processor. In such a system, the fluidics system may be adapted to flow a portion of a sample through the flowcell, and the image capture device may be configured to capture a plurality of images of blood cells in the flowcell. The processor may be programmed to perform a plurality of acts, including generating result data, displaying an interface operable to a user to select parameters, and displaying information corresponding to a review indication of the blood cells or the sample.
G01N 15/1031 - Recherche de particules individuelles en mesurant des effets électriques ou magnétiques
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 15/10 - Recherche de particules individuelles
G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G01N 15/1433 - Traitement du signal utilisant la reconnaissance d’image
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
A sample analysis system may comprise a flow imaging module, an alternative system, a fluidics system, and an analysis module. In such a system, the flow imaging module may comprise a flowcell and an image capture device, and the alternative system may comprise an impedance detector. The fluidics system may be adapted to flow portions of samples through the flow imaging and alternative systems. The analysis module may be adapted to determine values for a first plurality of parameters using data from the flow imaging module, and values for a second plurality of parameters using data from the alternative system.
G01N 15/1031 - Recherche de particules individuelles en mesurant des effets électriques ou magnétiques
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 15/10 - Recherche de particules individuelles
G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G01N 15/1433 - Traitement du signal utilisant la reconnaissance d’image
A sample analysis system including: a fluidics system adapted to: flow a first portion of a blood sample through a first module, the first module being a flow imaging module including a flowcell and an image capture device configured to capture a plurality of images of cells of the first portion of the blood sample; and flow a second portion of the blood sample through a second module, the second module configured to test for one or more numerical parameters of cells of the second portion of the blood sample; a processor programmed to: determine the one or more numerical parameters of cells of the second portion of the blood sample; and present a computing interface including the plurality of images of the cells of the first portion of the blood sample and the one or more numerical parameters of the cells of the second portion of the blood sample.
G01N 15/1031 - Recherche de particules individuelles en mesurant des effets électriques ou magnétiques
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines
Embodiments of the present invention encompass systems and methods for determining detection limits for various antibody-dye conjugates for flow cytometry. Exemplary techniques involve a linear superpositioning approach of spillover-induced enlargements of normally distributed measurement errors.
G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines
G01N 15/10 - Recherche de particules individuelles
A method of using an automatic chemical analyzer includes detecting in real-time abnormalities in a cuvette used with the analyzer and further detecting abnormal reaction conditions present in the cuvette used with the analyzer. Baseline signals are continuously updated and compared with subsequent signal recordings, as well as evaluating data, within a given subsequent signal recording itself. Signal criteria are used when evaluating and comparing signal recording data and the analyzer will indicate or provide an alert where a detected abnormality in the cuvette or reaction condition is identified.
G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p. ex. utilisation de bandes de papier indicateur
81.
METHODS FOR ASSESSING ANTIGEN SPECIFIC T-CELL RESPONSES
The present disclosure provides methods and kits for determining antigen-specific T-cell responses in a subject based upon the use of a whole blood sample, rather than isolated, concentrated, and/or extracted peripheral blood mononuclear cells. The use of a whole blood sample to measure antigen-specific T-cell responses in a subject streamlines the method by decreasing sample preparation and consumption. The methods for determining antigen antigen-specific T-cell responses in a subject include, contacting a whole blood sample from the subject with at least one antigen to form a mixture, contacting the whole blood sample with at least one staining reagent, and analyzing the mixture for antigen-specific T-cells.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
Improved systems and methods for laboratory instrument calibration. A laboratory instrument retrieves a number of sets of past quality control parameters from a data structure. Each set includes a recovered value and a timestamp. The recovered value is equal to an output value adjusted by an initial calibration factor. The laboratory instrument determines that the number of sets is greater than a threshold and that each of the past quality control parameters has a timestamp that is within a time threshold. The laboratory instrument computes an updated calibration factor such that when the updated calibration factor is applied to a representative value of the recovered values, the representative value equals the expected recovered value. The instrument updates the data structure with the calibration factor such that the calibration factor is used in subsequent testing of patient specimens.
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01D 18/00 - Test ou étalonnage des appareils ou des dispositions prévus dans les groupes
G01N 31/00 - Recherche ou analyse des matériaux non biologiques par l'emploi des procédés chimiques spécifiés dans les sous-groupesAppareils spécialement adaptés à de tels procédés
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
83.
DEVICE, SYSTEM AND METHOD FOR HANDLING SAMPLE CONTAINERS
Summarizing the invention, a robotic handling device for handling sample containers, wherein the sample containers are or are to be arranged within a sample container rack, is provided. The robotic handling device comprises: a gripping element for gripping and releasing the sample containers; a drive mechanism configured to move the gripping element; and at least one sensing device connected to the gripping element, wherein the at least one sensing device is configured to collect sensing data related to the sample container rack, the sensing data comprising optical imaging data and ranging data; wherein the drive mechanism is configured to move the gripping element based on recognition data related to the sample container rack, the recognition data being obtained from the sensing data.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B25J 15/08 - Têtes de préhension avec des éléments en forme de doigts
B65G 47/90 - Dispositifs pour saisir et déposer les articles ou les matériaux
A processing system for processing consumables, comprising: a container in which the consumables are arranged, the container comprising an RFID tag with at least one RFID tag storage section for storing consumables status information indicative of a filling-status of the consumables arranged in the container; an RFID reading unit configured to read information from the RFID tag; an RFID writing unit configured to write information on the RFID tag; and a removing unit configured to remove a part of the consumables from the container; wherein the processing system is configured to: read, by means of the RFID reading unit, the consumables status information from the at least one RFID tag storage section, remove, by means of the removing unit, a part of the consumables from the container, determine, based on the consumables status information read by the RFID reading unit, whether a predetermined prohibition condition is met after the removal of the part of the consumables from the container by the removing unit, and in case the prohibition condition is not met, update, by means of the RFID writing unit, the consumables status information on the RFID tag, and in case the prohibition condition is met, irreversibly modify the RFID tag such that the processing system is able to identify from the RFID tag that the prohibition condition is met.
G06K 17/00 - Méthodes ou dispositions pour faire travailler en coopération des équipements couverts par plusieurs des groupes principaux , p. ex. fichiers automatiques de cartes incluant les opérations de transport et de lecture
G06Q 10/087 - Gestion d’inventaires ou de stocks, p. ex. exécution des commandes, approvisionnement ou régularisation par rapport aux commandes
G06K 7/10 - Méthodes ou dispositions pour la lecture de supports d'enregistrement par radiation électromagnétique, p. ex. lecture optiqueMéthodes ou dispositions pour la lecture de supports d'enregistrement par radiation corpusculaire
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Chemical preparations and reagents, for scientific and research use; reagents, assays, and chemical preparations all for scientific, research, and laboratory purposes and analysis; chemical preparations, other than for medical or veterinary purposes; chemical reagents, other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; reagents and chemical preparations used for the identification and characterization of cells, for scientific and research use; panels of reagents, for scientific and research use; dyes and stains for the identification and characterization of cells, for scientific and research use; chemiluminescent reagents, for scientific and research use
(2) Chemical preparations and reagents, for medical purposes; reagents and chemical preparations, for medical diagnostic purposes; panels of reagents, for medical purposes; medical assays for testing of body fluids; chemicals and reagents for in vitro medical diagnostic use; reagents, assays, and chemical preparations for testing of biological specimens, for medical diagnostic purposes; medical diagnostic reagents and solutions, namely, diluents; antibiotics in test containers, canisters, panels and microtiter plates, for medical use; chemiluminescent reagents, for medical use
(3) Analytical apparatus and instruments for laboratory use and their parts, fittings, and accessories therefor and software sold therewith; laboratory apparatus and instruments, for scientific or research purposes and software for use in connection with the apparatus and instruments; downloadable and recorded software for use in operating, monitoring, and controlling laboratory and diagnostic apparatus and instruments and analyzing data generated by the apparatus and instruments; laboratory instruments for the analysis of biological samples and bodily fluids, for scientific and research purposes; laboratory robots; automated sample handling equipment, for scientific and research use; automated liquid handling instruments, for scientific and research use; cell analyzers; computer hardware and downloadable and recorded computer operating software for use with laboratory and diagnostic instruments, namely, for use in providing automation of laboratory processes, control and monitoring of laboratory instruments, instrument operation, sample management, connectivity, data analysis, and data management; downloadable and recorded software for technical support and advice, troubleshooting, diagnosis, repair, and maintenance of laboratory equipment and diagnostic instruments; recorded and downloadable software for use with laboratory instruments, namely, for use in monitoring and controlling the operation of the instrument, sample management, data collection, data management, and data analysis; recorded and downloadable software for collecting, managing, storing, analyzing, and reporting biological information, and for managing projects, laboratory workflows, and data, for use for scientific, diagnostic, and research purposes; computer system comprised primarily of computer hardware and computer software used for collecting, managing, interpreting, and analyzing data from laboratory instruments; downloadable and recorded data analysis software for laboratory, scientific, research, and medical use; computer software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; downloadable and recorded laboratory middleware software; downloadable and recorded software for clinical decision support; recorded and downloadable software for sample processing and storage, sample sorting, routing, sample scheduling and sample analysis for use with medical and laboratory diagnostic systems; laboratory consumables for scientific and research use, namely, laboratory specimen tubes, laboratory specimen bottles, test tube racks for laboratory specimen handling and storage, laboratory specimen tube rack inserts, test tube rack holders, pipette tips, probes, well plates, reagent bottles sold empty, reagent holding trays, funnels, droppers, dropper caps and waste bags specially adapted for holding laboratory waste, and rehydrator and inoculator devices for rehydrating and inoculating multiple wells with inoculum liquids
(4) Apparatus and instruments for medical diagnostic use and their parts, fittings, and accessories therefor and software sold as a unit therewith; clinical laboratory analyzers; apparatus and instruments for medical diagnostic use; instrument for the analysis of biological samples and bodily fluids, for medical purposes; medical diagnostic analyzers with computer hardware and computer software for use therewith, sold as a unit; instruments for use in automated microbial identification and susceptibility testing, for medical purposes; urine analyzers, for medical purposes; chemistry analyzers, for medical purposes; protein chemistry analyzers, for medical purposes; immunoassay apparatus and instruments, for medical purposes; hematology analyzers, for medical purposes; automated blood banking analyzers; automated sample handling and testing equipment; sample preparation device, for medical diagnostic uses
The disclosure relates to compositions comprising a non-fluorescent component of a polymer dye such as a monomeric component of a polymer dye, a photo-bleached polymer dye, and/or a polymer dye comprising a quenching moiety, for reducing non-specific interactions of polymer dye conjugates, for example, in Flow Cytometric Analysis of a biological sample. Methods for using such compositions, and kits comprising such compositions are also provided.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Lysis reagents for sample preparation, used in analysis for scientific and research purposes
(2) Lysis reagents for sample preparation, used in analysis for in vitro diagnostic use
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Lysis reagents for sample preparation used in analysis for scientific and research purposes Lysis reagents for sample preparation for medical use used in analysis for in vitro diagnostic use
Systems and methods for analyzing flow cytometry particles. A flow cytometry system is configured to direct a fluid stream of particles through an interrogation location, and includes a laser configured to emit light toward the interrogation location to produce light signals from the particles, and one or more detectors configured convert the light signals to waveform data. The flow cytometry system includes a waveform acquisition device to continuously digitize the waveform data, and a graphics processing unit configured to apply one or more adjustable threshold voltages to the digitized waveform data to extract event data for the particles.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G01N 15/10 - Recherche de particules individuelles
The disclosure relates to a substrate comprising a micro- or nanostructured periodic array comprised of a plurality of anisotropic metallic micro- or nanostructures, wherein each of the plurality of nanostructures induce an average maximum and substantially uniform plasmonic field greater than 108 across the substrate; a plurality of Raman-active linker molecules directly bound to the metallic micro- or nanostructures; and a plurality of capture molecules directly bound to the Raman-active linker molecules. The disclosure also relates to systems, devices, and methods that use the substrates to determine the concentration of various analytes.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
96.
AUTOMATIC QUALITY CHECK FOR LABORATORY INSTRUMENTS
Systems and methods for calibrating laboratory instruments. In an example, a laboratory instrument for testing patient specimens includes a testing apparatus configured to receive a cassette that includes a patient specimen or a quality control specimen. In response to determining that a quality control specimen is present, the instrument obtains a first measurement of a parameter. If the first parameter is outside an expected tolerance, the instrument ceases performing tests on all specimens, the instrument re-tests the quality control specimen to obtain a second measurement of the parameter. If the second measurement is within the expected tolerance, instrument resumes processing of the cassette. If the second measurement is outside the expected tolerance, the instrument indicates that recalibration or service is required.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
97.
SYSTEM AND METHOD FOR CALCULATING A DROPLET DELAY TIME, AND SORTING DEVICE
The present application discloses a system and a method for calculating a droplet delay time in a liquid flow of a sorting device, and a sorting device. The system includes: a first laser source configured to emit a first laser beam to a liquid flow of a sorting device, the first laser beam and the liquid flow intersecting at a first laser interrogation point located in a nozzle system of the sorting device; a second laser source configured to emit a second laser beam to the liquid flow, the second laser beam and the liquid flow intersecting at a second laser interrogation point located outside the nozzle system; a first detector and a second detector which are respectively used for detecting emission, in response to the first laser beam and the second laser beam, of a particle in the liquid flow; and a droplet delay time calculation unit configured to calculate, on the basis of the time when the particle in the liquid flow passes through the first laser interrogation point and the time when the particle passes through the second laser interrogation point, a first delay time for the liquid flow flowing from the first laser interrogation point to the second laser interrogation point, and calculate, on the basis of the first delay time, a droplet delay time.
The present disclosure relates to a nozzle for a sample processor, a carrier of a nozzle for a sample processor, a nozzle assembly for a sample processor, and a sample processor. The nozzle includes a body and an orifice. The body is adapted to be loaded and held in the carrier. The carrier can be slidably inserted into the sample processor in a detachable manner. The orifice is provided in the body and is configured to inject a sample from an injector body in a predetermined mode. An end surface of the body is adapted to abut against an end surface of the injector body along a sample injection direction. The nozzle assembly and the sample processor according to the present disclosure include the above-described nozzle and carrier. With the aid of the carrier, it is not necessary to install the nozzle to the injector body upstream of the nozzle, so that various adjustment operations when reinstalling the nozzle can be omitted, thereby simplifying the process of reinstalling the nozzle.
A system comprises: a sample analyzing device reading measurements associated with a liquid sample; a display device displaying a graphical user interface (GUI) to a current user of the automated sample analyzer; processing circuitry; and a memory storing: a receiving engine which receives the measurements associated with the liquid sample from the sample analyzing device and storing the received measurements in memory; a configuration control engine which sets a configuration of a user model to correspond to the current user of the automated sample analyzer; a learning engine which detects and collect at least one pattern of interaction of the current user with the GUI; and a user interface engine which configures the GUI according to user-dependent configuration data of the configuration of the user model corresponding to the current user.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
