A PCR device includes: a vessel configured to house a reaction solution to be subjected to PCR; a heater-cooler configured to heat and cool the reaction solution in the vessel; a cap configured to seal the vessel; and a detection end portion configured to be movable relative to the vessel, in a state of being mounted with the cap.
A solution collection device 100 comprises: a filtration container 14 in which a filter is formed on the bottom surface; a processing container 16 which houses the filtration container 14 in a state of receiving a solution of a biological substance containing impurities; a container holder 32 which holds the upper part of the filtration container 14 to move the filtration container 14 to the processing container 16; a dispensing nozzle 33 which sucks the solution of the biological substance from the filtration container 14 housed in the processing container 16; a vertical direction moving mechanism which moves the container holder 32 or the dispensing nozzle 33 in the vertical direction; and a lateral direction moving mechanism which moves the container holder 32 in the lateral direction.
C12M 1/28 - Inoculateur ou échantillonneur incorporé au récipient
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
G01N 1/00 - Echantillonnage; Préparation des éprouvettes pour la recherche
An extracting device 200 includes a plurality of extraction vessels 210 which retain a solution containing magnetic particles and a sample, an oscillating mechanism 220 which oscillates the extraction vessels 210, magnet bodies which exert a magnetic force on extraction vessels 210, a magnet moving mechanism 258, 259 which moves the magnet bodies between a contact position in which the magnet bodies are in contact with the extraction vessels 210 and a non-contact position, a temperature adjustment unit which adjusts a temperature of the extraction vessels 210, a temperature adjustment unit moving mechanism 248, 249 which moves the temperature adjustment unit between a contact position in which the temperature adjustment unit is in contact with the extraction vessels 210 and a non-contact position in which the temperature adjustment unit is not in contact with the extraction vessels 210, and a control unit which controls an action of each of the mechanisms.
A sample pooling system 1000 comprises a sample pooling device 200 that pools samples, a first PCR device 300 that performs a PCR on mixed samples, and a second PCR device 400 that performs a PCR on individual samples. The sample pooling device 200 comprises a single first rack 700a that accommodates a plurality of mixed sample containers in a row in the y direction; a plurality of second racks 700c that accommodate a plurality of individual sample containers in a row in the x direction; and a plurality of dispensation nozzles 240 that dispense a plurality of individual samples from the plurality of individual sample containers accommodated by a respective second rack 700c into a respective mixed sample container. The plurality of individual sample containers accommodated by one of the second racks 700c are aligned in the x direction with one of the plurality of mixed sample containers accommodated by the first rack 700a.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A specimen processing apparatus 1000 comprising: a plurality of container holders 510 holding, in one row, a plurality of second nucleic acid containers housing the nucleic acids; a pitch conversion mechanism 500 converting a pitch of the plurality of container holders between a smaller pitch and a larger pitch; a plurality of treatment lanes extracting the plurality of nucleic acid from a plurality of specimens in parallel; a first nozzle unit 200 including a plurality of first nozzles 210 disposed in one row at the greater pitch and moving over the plurality of treatment lanes; a PCR plate 128 having a plurality of wells disposed in one row at the smaller pitch; a second nozzle unit 300 including a plurality of second nozzles 310 disposed in one row at the smaller pitch and moving between a location above the plurality of container holders having the smaller pitch and a location above the PCR plate 128; and a control unit controlling operation of respective parts.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
6.
DISPENSING DEVICE, AND SPECIMEN PROCESSING AND MEASURING SYSTEM
A dispensing device 400 includes a plurality of dispensing nozzles arranged at predetermined intervals in x and y directions, a dispensing body 430 configured to support the plurality of dispensing nozzles, a mounting body 144 configured to allow a plurality of dispensing tips 142 to be mounted on the mounting body 144 at the predetermined intervals in the x and y directions, an attaching mechanism 432, 144b configured to attach the mounting body 144, on which the plurality of dispensing tips 142 are mounted, to the plurality of dispensing nozzles to install the plurality of dispensing tips 142 on the plurality of dispensing nozzles, a removing mechanism configured to remove the plurality of dispensing tips and the mounting body 144 from the plurality of dispensing nozzles, and a control unit configured to control operations of the plurality of dispensing nozzles, the attaching mechanism, and the removing mechanism.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
7.
GENE PANEL SEQUENCER AND GENE PANEL SEQUENCING METHOD
This gene panel sequencer 1 is provided with: a cartridge 30 having a plurality of dNTP wells 33 in which a plurality of dNTP solutions are placed respectively; a sequencing unit 10 which is movable in the longitudinal direction with respect to the cartridge 30, has a plurality of probe-attached beads to which a DNA sample is to be bound, and performs a nucleotide extension reaction for each of the probe-attached beads; a washing solution supply unit 60 which supplies a washing solution to an upper part of the sequencing unit 10; a cylinder unit 20 which performs the suction or ejection of the plurality of dNTP solutions between the plurality of dNTP wells and the sequencing unit 10; a flow path switching unit 11 which switches between a flow path from the solution supply unit 60 to the sequencing unit 10 and a flow path from the cylinder unit 20 to the sequencing unit 10; and a detection unit 50 which measures a nucleotide sequence in the sequencing unit 10.
A sampling device 1 comprises: an electrode nozzle 2; a nozzle movement mechanism that moves the electrode nozzle 2 in the vertical direction; a dispensing tip 3 that is attached to the electrode nozzle 2; a positive electrode 5a and a negative electrode 5b that are attached to the electrode nozzle 2 and that extend along the dispensing tip 3; a current detection unit 7 that detects the value of a current flowing between the positive electrode 5a and the negative electrode 5b; a sample container that houses a sample solution; and a control unit that controls the nozzle movement mechanism. While the control unit drives the nozzle movement mechanism to move the electrode nozzle 2 and the dispensing tip 3 in the vertical direction, the control unit specifies the position of a predetermined component layer from a change in the value of the current and drives the electrode nozzle 2 to sample the predetermined component layer.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
9.
KIT AND METHOD FOR COLLECTING BIOLOGICAL SUBSTANCE
The collection kit 1 according to the present invention comprises a collection tool 10 for collecting saliva, a container body for housing the collection tool 10 and a preservation solution for saliva, and a cap for closing the container body. The collection tool 10 comprises a saliva absorbent 12 for collecting saliva, a housing body 14 for housing the saliva absorbent 12, and a pressing body 16 for pressing a collection body 12 and forming a suction space S that is for sucking the saliva and the preservation solution from the outside of the container body 22.
A PCR device 100 comprises: a container 10 that contains a reaction liquid for conducting a PCR test; a heating-cooling device 30 that heats and cools the reaction liquid in the container 10; a lid 20 that seals the container; and a detection tip 40 that is movable with respect to the container with the lid 20 attached.
An extracting device 200 comprises: a plurality of extraction vessels 210 for holding a solution containing magnetic particles and a sample; an oscillating mechanism 220 for causing the extraction vessels 210 to oscillate; a magnetic body which exerts a magnetic force on the extraction vessels 220; magnet moving mechanisms 258, 259 for moving the magnetic body between a contacting position in which the magnetic body is in contact with the extraction vessels 210 and a non-contacting position in which the magnetic body is not in contact with the extraction vessels 210; a temperature regulating unit for regulating the temperature of the extraction vessels 210; temperature regulating unit moving mechanisms 248, 249 for moving the temperature regulating unit between a contacting position in which the temperature regulating unit is in contact with the extraction vessels 210 and a non-contacting position in which the temperature regulating unit is not in contact with the extraction vessels 210; and a control portion for controlling the operation of each mechanism.
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
A specimen treatment device 1000 comprising: a plurality of vessel holders 510 that hold, in a single row, a plurality of second nucleic acid vessels containing a plurality of batches of nucleic acid; a pitch transformation mechanism 500 that transforms the pitch of the plurality of vessel holders between a small pitch and a great pitch; a plurality of treatment lanes for extracting the plurality of batches of nucleic acid from a plurality of specimens in parallel; a first nozzle unit 200 that is provided with a plurality of first nozzles 210 disposed in a single row at the great pitch and that is moved above the plurality of treatment lanes; a PCR plate 128 having a plurality of wells disposed in single rows at the small pitch; a second nozzle unit 300 that is provided with a plurality of second nozzles 310 disposed in a single row at the small pitch and that is moved between a location above the plurality of vessel holders having the small pitch and a location above the PCR plate 128; and a control unit that controls operation of respective parts.
A dispensing device 400 comprises: a plurality of dispensing nozzles that are positioned at prescribed intervals in x- and y- directions; a dispensing body 430 that supports the plurality of dispensing nozzles; a mount 144 in which a plurality of dispensing tips are installed at prescribed intervals in the x- and y- directions; attaching mechanisms 432, 144b that attach the mount 144, which has the plurality of dispensing tips 142 installed therein, to the dispensing nozzle side in order to attach the the plurality of dispensing tips 142 to the plurality of dispensing nozzles; a detaching mechanism that detaches the plurality of dispensing tips and the mount 144 from the plurality of dispensing nozzles; and a control unit that controls the operation of the plurality of dispensing nozzles, the attaching mechanisms, and the detaching mechanism.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
A cartridge for nucleic acid detection is provided with: a first member having multiple nucleic acid extraction wells; a second member having a nucleic acid amplification and determination well for amplification of a nucleic acid and detection of the amplified nucleic acid; and multiple reagent containers. The multiple reagent containers are fixed between the first member and the second member.
A sample pooling system 1000 that comprises a sample pooling device 200 that pools samples, a first PCR device 300 that performs a PCR on mixed samples, and a second PCR device 400 that performs a PCR on individual samples. The sample pooling device 200 has: a single first rack 700a that accommodates a plurality of mixed sample containers in a row in the y direction; a plurality of second racks 700c that accommodate a plurality of individual sample containers in a row in the x direction; and a plurality of dispensation nozzles 240 that dispense a plurality of individual samples from the plurality of individual sample containers accommodated by a respective second rack 700c into a respective mixed sample container. The plurality of individual sample containers accommodated by one of the second racks 700c are aligned in the x direction with one of the plurality of mixed sample containers accommodated by the first rack 700a.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A specimen-dispensing system 1000 for suctioning and discharging of specimen solutions in a plurality of specimen containers using a plurality of nozzle units 228, the system comprising: a nozzle part 220 including the plurality of nozzle units 228; a pitch-converting mechanism 229 that converts the pitch in a y-direction between the plurality of nozzle units 228; a liquid level detection mechanism 260 that detects liquid level positions of the plurality of specimen containers; and a control unit 700 that moves the plurality of nozzle units 226 in a z-direction in accordance with the liquid level positions, and executes suctioning of the specimen solutions in the plurality of specimen containers.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
This sample treating device 1000 is provided with: a treating stage 110 for treating a sample by mixing the sample and a plurality of solutions; a first motor 812 for rotating the treating stage 110 around a first rotation shaft 810; a second motor for rotating the treating stage 110 around a second shaft 820; and a control unit for controlling the rotations of the treating stage driven by the first rotary motor 812 and the second motor. The control unit combines the operation of rotating the treating stage 110 around the first rotation shaft 810 and the operation of rotating the treating stage 110 around the second rotation shaft, thereby treating the sample.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
B03C 1/01 - Prétraitement spécialement adapté à la séparation magnétique par addition d'agents magnétiques
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p.ex. fermenteurs commandés automatiquement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
18.
KIT AND METHOD FOR COLLECTING BIOLOGICAL SUBSTANCE
The collection kit 1 according to the present invention comprises a collection tool 10 for collecting saliva, a container body for housing the collection tool 10 and a preservation solution for saliva, and a cap for closing the container body. The collection tool 10 comprises a saliva absorbent 12 for collecting saliva, a housing body 14 for housing the saliva absorbent 12, and a pressing body 16 for pressing a collection body 12 and forming a suction space S that is for sucking the saliva and the preservation solution from the outside of the container body 22.
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
19.
Optical measurement device for reaction vessel and method therefor
An optical measurement device is provided. The device includes first and second optical fibers; first and second reaction vessels, and a light guide stage coupled to the first and second optical fibers. The light guide stage is driven to simultaneously optically connect the first and second optical fibers with the first and second reaction vessels. The device includes a measurement device for receiving emissions from the first and second reaction vessels, and a connecting end arranging body that supports the first and second optical fibers along a path. The arranging body is driven along the path between a first position, in which the first optical fiber is optically connected with the measurement device so that light is transmittable from the first reaction vessel, and a second position, in which the second optical fiber is optically connected with the measurement device so that light is transmittable from the second reaction vessel.
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
20.
Photometric dispensing nozzle unit, photometric dispensing apparatus, and photometric dispensing method
A photometric dispensing nozzle unit, a photometric dispensing apparatus, and a photometric dispensing method are for preventing an increase in apparatus scale and have a simple structure to be easily handled. A nozzle performs suction/discharge of gas through a distal end opening and can have a dispensing tip attached thereto. A light guide end portion is provided in the nozzle and can receive or irradiate light at a distal end of the nozzle. A dispensing cylinder has a cylinder having a cavity therein, a plunger that is slidable in the cavity, and a suction/discharge port that performs suction/discharge of gas. A suction/discharge flow path passes through the nozzle and communicates with the suction/discharge port and the distal end opening of the nozzle. A light guide path is optically connected to the light guide end portion through the nozzle but not through the dispensing cylinder.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
This sample treating device 1000 is provided with: a treating stage 110 for treating a sample by mixing the sample and a plurality of solutions; a first motor 812 for rotating the treating stage 110 around a first rotation shaft 810; a second motor for rotating the treating stage 110 around a second shaft 820; and a control unit for controlling the rotations of the treating stage driven by the first rotary motor 812 and the second motor. The control unit combines the operation of rotating the treating stage 110 around the first rotation shaft 810 and the operation of rotating the treating stage 110 around the second rotation shaft, thereby treating the sample.
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 3/08 - Appareils pour la désagrégation des tissus
A specimen treating and measuring system according to the present invention comprises: a treatment part having a plurality of lanes for carrying out parallel processing of a plurality of specimens, and mounting cartridges in each of the plurality of lanes; a cartridge storing unit storing a plurality of types of cartridge to be used for different processes corresponding to the plurality of specimens; a sample storing unit storing and conveying sample tubes containing the plurality of specimens; a pickup unit transferring each of the plurality of types of cartridge to each lane, and transferring each of the plurality of specimens from the sample tubes to each of the plurality of lanes; and a control unit controlling the transfer of the plurality of types of cartridge and the transfer of the plurality of specimens, performed by the pickup unit.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A cartridge 100 for nucleic acid detection is provided with: a first member 110 having multiple nucleic acid extraction wells; a second member 120 having a nucleic acid amplification and determination well for amplification of a nucleic acid and detection of the amplified nucleic acid; and multiple reagent containers 130. The multiple reagent containers 130 are fixed between the first member 110 and the second member 120.
The specimen treatment and measurement system 2000 according to the present invention is provided with: a movement stage 2300 having a plurality of treatment lanes for treating specimens in parallel; a consumables supply module 2100 for storing consumables for use in treatment of the specimens, and supplying the consumables to the movement stage 2300; a cartridge supply module 2500 for storing cartridges for use in treatment of the specimens, and supplying the cartridges to the movement stage 2300; and a stage transfer mechanism 2400 for transferring the movement stage 2400 to each module. The cartridge supply module 2500 has a plurality of cartridge cartons for accommodating the cartridges stacked on top of each other, and a push-out mechanism for pushing cartridges out of a cartridge carton to a supply position of the cartridge supply module 2500.
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
25.
Dispensing cylinder, and dispensing device and dispensing treatment method using same
A dispensing cylinder capable of performing a dispensing treatment for both minute and large amounts of liquid includes: a cylinder having a cavity; a nozzle provided at one end of the cylinder, having a through hole in fluid communication with the cavity and extending in an axial direction of the cavity, and a plunger slidable in the cavity in the axial direction. The cavity has a large diameter region having a large inner peripheral surface and a small diameter region having a second inner peripheral surface. The plunger has a thick shaft portion slidable in the large diameter region and a thin shaft portion protruding from a distal end of the thick shaft portion in the axial direction and slidable in the small diameter region.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 1/00 - Echantillonnage; Préparation des éprouvettes pour la recherche
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
26.
FULLY AUTOMATIC TREATMENT APPARATUS FOR ELECTROPHORESIS, AND METHOD FOR SAME
[Problem] To provide a fully automatic treatment apparatus for electrophoresis and a method for the same, whereby a sequence of steps from extraction from a sample of an object substance, labeling, processing, and analysis can be consistently automated, and treatment can be rapidly and efficiently executed. [Solution] The present invention is configured so as to have: a capillary electrophoresis unit having a plurality of electrophoretic capillaries, the capillary electrophoresis unit inducing electrophoresis in an object substance in the capillaries by applying a voltage; an electrophoresis pre-treatment unit whereby each capillary of the capillary electrophoresis unit is supplied with an electrophoretic reagent containing the object substance obtained through extraction treatment of the object substance, processing treatment, and a quality evaluation related to each treatment; a light selection measurement unit for making a selection from a group comprising light measurements related to the capillaries of the electrophoresis unit and light measurements for quality evaluation of the electrophoresis pre-treatment unit, and enabling any one or more light measurements to be executed; and a control unit for controlling the extraction treatment of the object substance, the processing treatment, the analysis treatment, and the quality evaluation in each treatment.
G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
The invention relates to an optical measurement device for a reaction vessel, and a method therefor. An object is to measure the optical state within a reaction vessel in an efficient, rapid, and highly reliable manner, without an expansion of the device scale. The configuration includes: a vessel group in which two or more reaction vessels are arranged; a light guide stage having two or more linking portions to which front ends of light guide portions, which have a flexibility, that optically connect with the interior of the linked reaction vessels, are provided; a connecting end arranging body that has an arranging surface that arranges and supports along a predetermined path two or more connecting ends, to which back ends of the light guide portions, in which the front ends thereof are provided to the linking portions, are provided, the connecting ends are provided corresponding to the respective linking portions; a measurement device provided approaching or making contact with the arranging surface that has measuring ends that are successively optically connectable with the respective connecting ends along the predetermined path, and in which light from within the reaction vessels is receivable by means of optical connections between the connecting ends and the measuring ends; and a light guide switching mechanism that relatively moves the respective connecting ends arranged on the connecting end arranging body and the respective measuring ends such that they are successively optically connected.
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
28.
General-purpose optical measuring device and method of same
A general-purpose optical measuring device enables at least measurement of a nucleic acid amplification amount; detection or quantitative measurement by a nucleic acid detection method, an immunoassay method, an enzyme method; or measurement of concentration or absorbance, and a method of the same. There are included a photometric content designation unit, an irradiation reception pair including an emission end that can emit measurement light, and a reception end that can receive light from the emission end, a photometric container that can store measurement target chemical substance solution, and includes a bottom portion having a formed translucent region, a nozzle communicated with a suction discharge mechanism of gas, a flow tube, an optical measurement unit, and a control unit configured to suck and hold the chemical substance solution into the flow tube, or store the chemical substance solution into the photometric container.
G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
G01N 21/01 - Dispositions ou appareils pour faciliter la recherche optique
G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A highly-reliable absorbance measuring device that enables highly-accurate measurement of absorbance, and a method thereof are provided.
A liquid containing unit that can contain a chemical substance solution to be measured, a nozzle that communicates with a suction/discharge mechanism that sucks/discharges gas, a flow tube that includes a mouth part, which can be inserted into the liquid containing unit, at a lower end and that is detachably attached to the nozzle at an upper end, an emitting end that can emit measurement light, a light receiving end that can receive the light emitted from the emitting end, and a control unit are included. The control unit is configured to suck a prescribed amount of the chemical substance solution into the flow tube, and to lead absorbance on the basis of intensity of transmitted light acquired by emission of measurement light in a vertical direction into the flow tube.
G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
G01N 21/31 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique
G01N 21/82 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un précipité ou une turbidité
It is an object to provide a deforming element-included dispensing tip, a deforming element-included dispensing device, and a deforming element-included dispensing processing method not requiring any cylinder and capable of achieving highly precise position control and enhancing integration of higher density and reducing the burden in the quality control in reaction processing of a biological material for extraction of DNA and the like. A tip-shaped container formed with a non-deforming wall having an opening portion at an upper side and an inlet unit at a lower side for allowing fluid to flow in and flow out and a sealing plug attached to the opening portion so as to seal the opening portion are provided, and the sealing plug is configured to be provided with a deforming element.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01J 4/00 - Dispositifs d'alimentation; Dispositifs de commande d'alimentation ou d'évacuation
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
A cartridge 100 for nucleic acid detection is provided with: a first member 110 having multiple nucleic acid extraction wells; a second member 120 having a nucleic acid amplification and determination well for amplification of a nucleic acid and detection of the amplified nucleic acid; and multiple reagent containers 130. The multiple reagent containers 130 are fixed between the first member 110 and the second member 120.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
32.
PHOTOMETRIC DISPENSING NOZZLE UNIT, PHOTOMETRIC DISPENSING APPARATUS, AND PHOTOMETRIC DISPENSING METHOD
The purpose of the present invention is to provide a photometric dispensing nozzle unit that prevents increase in size and that is formed simple in structure so as to be easily handled, a photometric dispensing apparatus, and a photometric dispensing method. The present invention is configured so as to have: a nozzle from which a gas is sucked/discharged through a leading-end opening and to which a dispensing tip can be mounted; a light guide end that is provided to the nozzle and enables reception or emission of light at the leading-end of the nozzle; a dispensing cylinder that has a cylinder having a cavity therein, a plunger that is slidably provide in the cavity, and a suction/discharge port through which the gas is sucked/discharged; a suction/discharge flow path that passes through the nozzle and connects the suction/discharge port with the leading-end opening of the nozzle; and a light guide path that is optically connected to the light guide end through the nozzle but not through the dispensing cylinder.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
The specimen treatment and measurement system 2000 according to the present invention is provided with: a movement stage 2300 having a plurality of treatment lanes for treating specimens in parallel; a consumables supply module 2100 for storing consumables for use in treatment of the specimens, and supplying the consumables to the movement stage 2300; a cartridge supply module 2500 for storing cartridges for use in treatment of the specimens, and supplying the cartridges to the movement stage 2300; and a stage transfer mechanism 2400 for transferring the movement stage 2400 to each module. The cartridge supply module 2500 has a plurality of cartridge cartons for accommodating the cartridges stacked on top of each other, and a push-out mechanism for pushing cartridges out of a cartridge carton to a supply position of the cartridge supply module 2500.
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
A device for electrical measurement of a target chemical substance includes: an electrode array element including a base, an electrode array section in which electrodes which are disposed on the base and to each of which a test substance is fixed or can be fixed are arrayed, and a terminal array section in which terminals disposed on the base so as to correspond to the electrodes and electrically connected to the electrodes are arrayed; a processing head having an electrode array element support section supporting the electrode array element detachably to make electrical connection to the terminals possible; a container group including a liquid storing section and a measurement container; a support section moving mechanism; and a measurement section capable of measuring a signal generated by applying a predetermined voltage to a test substance fixed to each of the electrodes in the measurement container.
G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
G01N 27/27 - Association de plusieurs systèmes ou cellules de mesure, chacun mesurant un paramètre différent, dans laquelle les résultats des mesures peuvent être, soit utilisès indépendamment, les systèmes ou les cellules étant physiquement associés, soit combin
G01N 27/28 - Composants de cellules électrolytiques
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
36.
Lightguide aggregate inspection device and inspection method of the same
A lightguide aggregate inspection device includes a reaction spot array including multiple reaction spot array elements having at least one reaction spot, a light-receiving element array having a light-receiving surface provided with multiple light-receiving regions each having at least one light-receiving element corresponding to each of the reaction spot array elements, and receiving light obtained based on an optical state resulting from reaction in each of the reaction spots, multiple lightguide paths provided to correspond to the reaction spot array elements, and each having a measurement end provided close to or in contact with, or to be movable close to or into contact with 1 reaction spot, and a connection end provided close to or in contact with the light-receiving region, and a digital data conversion unit configured to convert image region data obtained from the light-receiving elements corresponding to the light-receiving regions, into digital data.
G01J 3/46 - Mesure de couleur; Dispositifs de mesure de couleur, p.ex. colorimètres
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
G01N 21/03 - Dispositions ou appareils pour faciliter la recherche optique - Détails de structure des cuvettes
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
F21V 8/00 - Utilisation de guides de lumière, p.ex. dispositifs à fibres optiques, dans les dispositifs ou systèmes d'éclairage
H01L 31/167 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails structurellement associés, p.ex. formés dans ou sur un substrat commun, avec une ou plusieurs sources lumineuses électriques, p.ex. avec des sources lumineuses électroluminescentes, et en outre électriquement ou optiquement couplés avec lesdites sour le dispositif à semi-conducteur sensible au rayonnement étant commandé par la ou les sources lumineuses les sources lumineuses et les dispositifs sensibles au rayonnement étant tous des dispositifs semi-conducteurs caractérisés par au moins une barrière de potentiel ou de surface
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
37.
Multiple reaction parallel measurement apparatus and method for the same
A multiple reaction parallel measurement apparatus is intended to measure a large number of reactions quickly, simply and with high accuracy. The apparatus includes: a plurality of light guiding paths corresponding to a plurality of reaction spot array elements, including a measuring end able to be in proximity of or in contact with each one of the reaction spots, and arranged to guide light generated by a reaction at the reaction spot to a connecting end; a measurement head arranged such that the measuring ends reach all together predetermined measurement positions of the corresponding reaction spots of the reaction spot array elements at a predetermined scan period; a light guiding path selector including a light guiding region optically connected to the connecting end; a light receiving unit; and a digital data converter to obtain digital data by converting image region data obtained from the light receiving unit.
G01N 21/03 - Dispositions ou appareils pour faciliter la recherche optique - Détails de structure des cuvettes
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
38.
DISPENSING CYLINDER, AND DISPENSING DEVICE AND DISPENSING TREATMENT METHOD USING SAME
The present invention relates to a dispensing cylinder and to a dispensing device and dispensing treatment method which use the dispensing cylinder, and the purpose of the present invention is to provide a high-precision dispensing cylinder that is compact and easily handled and that is also capable of performing dispensing treatment of both minute amounts and large amounts of a liquid using a single mechanism, and a dispensing device using the dispensing cylinder and a dispensing treatment method using the dispensing cylinder. The dispensing cylinder has: a cylinder having a cavity in the inside thereof; a nozzle to which a dispensing chip can be mounted, the nozzle being provided to one end of the cylinder, and a through-hole communicating with the cavity and extending along the axial direction of the cavity being provided in the nozzle; and a plunger provided so as to be able to slide along the axial direction through the inside of the cavity; the cavity having a large-diameter region having a large-diameter internal peripheral surface, and a small-diameter region having a small-diameter internal peripheral surface, the small-diameter region being provided on a nozzle side of the large-diameter region, and the plunger being configured so as to have a thick shaft part provided so as to be able to slide through the large-diameter region, and a thin shaft part protruding along the axial direction from a distal end of the thick shaft part and being provided so as to be able to slide to the small-diameter region.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01J 4/02 - Dispositifs d'alimentation; Dispositifs de commande d'alimentation ou d'évacuation pour introduire des quantités mesurées de réactifs
A sample processing and measuring system 1000 according to the present invention is provided with: a processing unit 110 which is provided with a plurality of lanes for carrying out parallel processing of a plurality of samples, and which mounts cartridges 112 in each of the plurality of lanes; a cartridge storing unit 700 which stores a plurality of types of cartridge to be used for different processes corresponding to the plurality of samples; a sample storing unit 600 which stores and conveys sample tubes containing the plurality of samples; a pickup unit 300 which transfers each of the plurality of types of cartridge 112 to each lane, and transfers each of the plurality of samples from the sample tubes to each of the plurality of lanes; and a control unit which controls the transfer of the plurality of types of cartridge and the transfer of the plurality of samples, performed by the pickup unit 300.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
40.
GENERAL PURPOSE OPTICAL MEASURING DEVICE AND METHOD
The objective of the present invention is to provide a general purpose optical measuring device and method which enable, at least, measurement of an amount of nucleic acid amplification, detection or quantitative measurement by means of nucleic acid detection, an immunoassay or an enzymatic method, or measurement of concentration or light absorbency. This general purpose optical measuring device is provided with: a photometric content designating unit; a light radiating and receiving pair comprising a radiating end capable of radiating measurement light and a light receiving end capable of receiving light from the radiating end; a photometry container which is capable of accommodating a chemical substance solution to be measured, and which has a bottom portion in which a translucent region is formed; a nozzle which communicates with a gas suction and discharge mechanism; a flow tube of which a lower end can be inserted into the photometry container and to an upper end of which the nozzle is fitted; a light measuring unit; and a control unit which causes the chemical substance solution to be sucked into and held in the flow tube to which the nozzle is fitted, or to be accommodated in the photometry container, and derives a physicochemical property or value of the chemical substance solution on the basis of the intensity of light received by the light receiving end. One element of the light radiating and receiving pair is provided in the nozzle or in the suction and discharge mechanism, and the other element thereof is configured in such a way that an upper side thereof is disposed in the translucent region.
G01N 21/01 - Dispositions ou appareils pour faciliter la recherche optique
G01N 21/03 - Dispositions ou appareils pour faciliter la recherche optique - Détails de structure des cuvettes
G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
41.
ELECTROPHORESIS CHIP, ELECTROPHORESIS DEVICE AND ELECTROPHORESIS SYSTEM
The electrophoresis chip 1 according to the present invention comprises an electrophoresis tube 100 housing a gel for electrophoresis therein, a positive electrode 300 applying a positive potential to the lower end side of the electrophoresis tube, a negative electrode 400 applying a negative potential to the upper end side of the electrophoresis tube 100, and a holder 200 integrally holding the electrophoresis tube 100 and the both electrodes 300 and 400.
To provide a highly reliable absorbance measuring apparatus and method for enabling high-precision measurements of absorbance. The absorbance measuring apparatus has: a liquid-accommodating portion capable of accommodating a chemical substance solution to be measured; a nozzle communicating with a suction and ejection mechanism for suctioning or ejecting a gas; a flow pipe, on the lower end of which a mouth part, which can be inserted into the liquid accommodating portion, removably attaches thereto, and at the upper end of which removably attaches to the nozzle; an irradiating end capable of radiating light for measurement; a light-receiving end capable of receiving light radiated from the irradiating end; and a control unit. Either the irradiating end or the light-receiving end is arranged at the nozzle or the suction and ejection mechanism, and the other of the irradiating end and the light receiving end is arranged so that the mouth part of the flow pipe can be oriented vertically. The control unit derives the absorbance on the basis of the intensity of light obtained by suctioning a regulated amount of the chemical substance solution into the flow pipe, and vertically radiating light for measurement into the flow pipe.
G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
The invention relates to a method and apparatus for measuring the optical state on the inside of a reaction vessel. The apparatus includes: linking portions that optically connect with the interior of the reaction vessel that is linkable with reaction vessels, a connecting end arranging body having an arranging surface that arranges and supports along a predetermined path, connecting ends to which is provided back ends of the light guide portions, the front ends thereof being provided to the linking portions, the connecting ends being provided to the linking portions; a measurement device having measuring ends that are successively optically connectable with the connecting ends, and in which light based on the optical state is receivable by optical connections between the connecting ends and the measuring ends; and a light guide switching mechanism that successively optically connects the connecting ends and the measuring ends.
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c. à d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
In a method of nucleic acid extraction using a support, the present invention realizes collection of a nucleic acid from a liquid containing the nucleic acid at an extremely low concentration at which collection cannot be achieved with polyacrylamide.
A method of extracting a nucleic acid, comprising allowing the nucleic acid to be adsorbed onto a support in the presence of a chaotropic salt and an alcohol in coexistence with an anionic polymer. A reagent for nucleic acid extraction, comprising an anionic polymer, a chaotropic salt, an alcohol and a support.
The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have: a container group in which a plurality of reaction containers are arranged; a measurement mount provided with a plurality of coupling ends that are joinable with apertures of the reaction containers, and have light guide portions that optically connect with the interior of the joined reaction containers; a mount transfer mechanism; a measuring device having a measuring end having at least one light guide portion that is optically connectable to the light guide portions of the coupling ends, that is able to receive light based on an optical state within the reaction containers; an on-mount measuring end transfer mechanism; and a measurement control portion.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
G01N 21/13 - Transport des cuvettes ou des échantillons solides vers ou à partir de l'emplacement de recherche
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 21/31 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
A reaction container control system including a reaction container, a sealing lid, a temperature control block, and a heater. The reaction container includes a lower side wall section, an upper side wall section, and an aperture. The sealing lid seals the reaction container by fitting to the aperture of the reaction container. When the sealing lid is fitted to the aperture, light based on an optical state within the reaction container is receivable by a measuring device via the sealing lid. The temperature control block contacts or extends adjacent the lower side wall section, and includes a temperature source operable to increase or decrease a temperature inside the reaction container. The heater contacts or extends adjacent the upper side wall section, and includes a heat source operable to heat the reaction container to prevent condensation on the sealing lid fitted to the aperture.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 21/13 - Transport des cuvettes ou des échantillons solides vers ou à partir de l'emplacement de recherche
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 21/31 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
48.
Automatic response/light measurement device and method therefor
The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have: a container group in which a plurality of reaction containers are arranged; a measurement mount provided with a plurality of coupling ends that are joinable with apertures of the reaction containers, and have light guide portions that optically connect with the interior of the joined reaction containers; a mount transfer mechanism; a measuring device having a measuring end having at least one light guide portion that is optically connectable to the light guide portions of the coupling ends, that is able to receive light based on an optical state within the reaction containers; an on-mount measuring end transfer mechanism; and a measurement control portion.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 21/13 - Transport des cuvettes ou des échantillons solides vers ou à partir de l'emplacement de recherche
G01N 21/31 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
49.
Cartridge container for preservation of amplification reagents
The present invention pertains to a device for electrical measurement of target chemical substances, and a method therefor, and the purpose of the present invention is to provide a highly reliable device which is compact and inexpensive. The present invention is configured to comprise: an electrode array element including a substrate, an electrode array section having arrayed therein electrodes which are provided on the substrate and to which respective test substances are fixed or fixable, and a terminal array section having arrayed therein terminals which are provided on the substrate to correspond to the respective electrodes and which are electrically connected to the electrodes; a processing head having an electrode array element supporting part that supports the electrode array element in an attachable and detachable manner to electrically connect the electrode array element to the terminals; a container group including a liquid storing part and a measurement container; a supporting part moving mechanism that makes the electrode array element supporting part relatively movable with respect to the container group; and a measurement part that can measure a signal generated through application of a predetermined voltage to the test substances fixed to the electrodes in the measurement container, wherein the container group has a storage part storing or capable of storing the electrode array element such that the electrode array element can be supported by the electrode array element supporting part through the supporting part moving mechanism.
G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
G01N 27/27 - Association de plusieurs systèmes ou cellules de mesure, chacun mesurant un paramètre différent, dans laquelle les résultats des mesures peuvent être, soit utilisès indépendamment, les systèmes ou les cellules étant physiquement associés, soit combin
G01N 27/28 - Composants de cellules électrolytiques
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
51.
PARALLEL MEASUREMENT DEVICE AND PARALLEL MEASUREMENT METHOD FOR MULTIPLE REACTIONS
The present invention pertains to a parallel measurement device and a parallel measurement method for multiple reactions, and the objective of the present invention is to measure a number of reactions quickly, easily, and accurately. The present invention is configured to comprise, at least: a plurality of light guiding paths which are provided corresponding to a plurality of reaction spot array elements having a plurality of reaction spots, each of which has a measurement end arranged approachable to a corresponding one of the reaction spots, and which can guide, to a connection end, light which can be generated due to a reaction at the reaction spot; a measurement head that is provided so as to be relatively movable such that the measurement ends simultaneously reach predetermined measurement positions of the corresponding reaction spots of the reaction spot array elements with a predetermined scanning cycle; a light guiding path selection unit that includes a light guiding area which optically connects to the connection ends of the light guiding paths that are sequentially selected with a predetermined selection cycle, while the measurement ends are moving to the predetermined measurement positions or are stopped at the positions, to allow incident light to be emitted; a light receiving unit; and a digital data conversion unit which, with a predetermined selection cycle, converts image region data obtained from the light receiving unit to sequentially obtain digital data.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
52.
Chemiluminescence measurement device and method for same
The present invention relates to a device and method for measuring chemiluminescence, and an object is to provide a compact and reliable device and method for measuring chemiluminescence. The device includes a vessel group, a nozzle head having a gas suctioning and discharging mechanism, one or more nozzles, which are in communication with the suctioning and discharging mechanism, and to a front end of which a dispensing tip is attachable, and a magnetic force means capable of causing a magnetic field inside the attached dispensing tip, a nozzle moving mechanism, a linkage part provided to the nozzle head, linkable to the reaction vessel and capable of forming a confined space shielded from external light, a linkage part moving mechanism capable of moving the linkage part, a photometer, a shutter, and a reagent injection flow channel capable of injecting a reagent for chemiluminescence.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A culture system comprises: a preparatory culture vessel and a main culture vessel that accommodate cells and a solution; a main stage that holds the preparatory culture vessel and the main culture vessel; a connecting tube that connects the culture vessels; a valve that opens and closes the connecting tube; and a rotating mechanism that rotates the main stage and imparts a height difference between the culture vessels to transfer the cells and solution by dropping between the culture vessels.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p.ex. fermenteurs commandés automatiquement
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores
C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
54.
Culture device, culture system, and culture method
This culture device comprises: a culture container which houses cells, magnetic particles and a culture medium; a temperature adjustment unit for adjusting the temperature of the culture container; a magnet which is provided to the outside of the culture container; a magnetic force adjustment unit for adjusting the magnetic force of the magnet; and a control unit for controlling the operation of the magnetic force adjustment unit. The magnetic force adjustment unit adjusts the magnetic force of the magnet, thereby holding magnetic particles and cells in a predetermined region within the culture container, or dispersing the magnetic particles and cells within the culture container.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12N 13/00 - Traitement de micro-organismes ou d'enzymes par énergie électrique ou ondulatoire, p.ex. par magnétisme, par des ondes sonores
A sequencer pretreatment device includes a suction and discharge mechanism, a nozzle head having a nozzle for mounting a dispensing tip, a container group for accommodating liquids including magnetic particle suspension, a moving mechanism for causing relative movement between the nozzle and the container group, and a magnetic unit that exerts a magnetic field to the mounted dispensing tip. A method includes an extraction step of mixing a sample, extraction reagent solution, and magnetic particle suspension in the container group and extracting nucleic acid, a fragmentation producing step of fragmentating the nucleic acid by mixing with fragmentation solution accommodated in the container group and producing a fragment of a base sequence having a molecular weight corresponding to a sequencer using magnetic particle suspension using the sequencer pretreatment device, and an amplification pretreatment step of dispensing a solution containing the fragment into the reaction vessel using the sequencer pretreatment device.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]
B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en général; Appareils appropriés
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
The present invention provides a magnetic particle reaction control apparatus utilizing a variable-pitch dispensing apparatus, which prevents expansion of apparatus scale and is capable of handling containers of various pitches, and a reaction control method therefor. The invention is provided with a nozzle head having a plurality of nozzles which have tip sections and are arranged in a single row at a variable pitch, and a pitch conversion mechanism capable of converting the nozzles between a first pitch and a second pitch by command; a first receiving section group having receiving sections which are arranged, at a first pitch, in at least one row along a row direction, and into which the tip sections can be inserted simultaneously, and a second receiving section group having receiving sections which are arranged, at a second pitch smaller than the first pitch, in at least one row in the row direction; a movement mechanism which allows the nozzle head or nozzles to be moved with respect to the receiving section groups; and a magnetic device capable of applying and removing a magnetic field, simultaneously inside the tip sections of the nozzles arranged at the first pitch or the second pitch; wherein either the first receiving section group or the second receiving section group contains magnetic particle suspensions.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B03C 1/10 - Séparation magnétique agissant directement sur la substance à séparer ayant des supports pour le matériau traité, de forme cylindrique
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
57.
Automated nucleic acid processor and automated nucleic acid processing method using multi function dispensing unit
In relation to an automated nucleic acid processor and an automated nucleic acid processing method using a multi function dispensing unit, processing involving extraction and amplification of the nucleic acid, can be consistently, quickly and efficiently conducted at a low cost with the use of a multi function dispensing unit, while saving user's trouble without expanding the scale of the device. The multi function dispensing unit includes: a nozzle head provided with a suction-discharge mechanism and nozzles detachably provided with dispensing tips; a container group having, at the very least housing parts for liquids and reaction containers for housing an amplification solution; a transfer mechanism that makes an interval between the nozzles and the container group relatively movable; a temperature controller whereby temperature control of the interior of the reaction vessels is possible; sealing liquids and/or sealing lids that are transportable to the reaction vessels using the nozzles, and which make the amplification solutions housed in the reaction vessels sealable within the reaction vessels; and a sealing control part that controls the suction-discharge mechanism or the transfer mechanism, such that the sealing liquid and/or the sealing lids seal the amplification solution within the reaction vessels when the housing of the amplification solution in the reaction vessels is completed.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
58.
Linear movement type reaction treatment apparatus and method thereof
An apparatus and related method to reliably prevent cross-contamination and to decrease working time or space involved with reaction treatment. The apparatus includes: a container group having one or more reaction containers and two or more liquid storage portions arranged in a linear shape; a dispensing head to which one or more dispensing tips insertable into the container group are detachably attached, the dispensing head being relatively movable with respect to the container group in a linear direction; a magnetic portion provided in the dispensing head and capable of: applying a magnetic field into each dispensing tip so that the magnetic particles are adsorbed to an inner wall of the dispensing tip, and removing the magnetic field so that the magnetic particles are resuspended in a solution; and an ultrasonic vibration device which applies ultrasonic vibration to a sample storage portion including at least one of the liquid storage portions.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
59.
Analysis method and analysis kit for simultaneously detecting or quantitating multiple types of target substances
The present invention provides an analysis method for simultaneously detecting or quantifying plural species of target substances by measuring the light emission from plural carriers within a single container from outside of the container, these carriers comprising a plurality of substances that are respectively immobilized thereon for capturing the plural species of target substances, wherein the light emission from a desired carrier is selectively received by measuring the emission from the carriers through an optical filter. The present invention also provides an analysis kit for simultaneously detecting or quantifying plural species of target substances by measuring the light emission from plural carriers within a single container from outside of the container, these carriers comprising a plurality of substances that are respectively immobilized thereon for capturing the plural species of target substances, which comprises the plural carriers and an optical filter for selectively receiving the emission from a desired carrier.
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique
The purpose of the present invention is to achieve the collection of a nucleic acid from a liquid containing the nucleic acid at an extremely low concentration in a nucleic acid collection method using a carrier, which cannot be achieved using polyacrylamide. A nucleic acid extraction method characterized in that a nucleic acid is allowed to adsorb onto a carrier in the presence of a chaotropic salt and an alcohol and in the co-presence of an anionic polymer. A nucleic acid extraction reagent comprising an anionic polymer, a chaotropic salt, an alcohol and a carrier.
The purpose of this lightguide aggregate inspection device and inspection method thereof is to quickly and efficiently perform inspections for multiple reaction spots. This inspection device is provided with: a reaction spot array comprising multiple reaction spot array elements having at least one reaction spot; a light receiving element array which has a light-receiving surface on which, corresponding to the reaction spot array elements, multiple light-receiving regions are provided which have at least one light-receiving element and which receive light based on the optical state resulting from reactions at each reaction spot; multiple lightguide paths which are provided corresponding to the reaction spot array elements, each of the lightguide paths having a measurement end which is close to or in contact with, or can move close to or can move into contact with, one reaction spot, and a connection end provided to be close to or in contact with the light-receiving region; a digital data conversion unit which, at a prescribed period, converts, into digital data, image region data obtained from the light-receiving element corresponding to the light-receiving region; and a storage means which sequentially stores said data.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
62.
Bellows type dispensing tip, bellows type dispensing apparatus and method of bellows type dispensing processing
There is provided a bellows type dispensing tip, a bellows type dispensing apparatus, and a method of bellows type dispensing processing that performs highly precise dispensing processing despite having a simple structure. The apparatus comprises; two or more bellows type dispensing tips having; an accommodating section that is capable of accommodating a liquid or gas in the interior thereof surrounded by a wall face, and that has a deformable deforming wall face in a portion of the wall face, and an opening section communicated with the accommodating section, through which the liquid to be suctioned/discharged can flow in and flow out due to expansion and contraction of the interior caused by deformation of the deforming wall face; and a dispensing head that supports the bellows type dispensing tips, and that performs suction/discharge of the liquid into or from the bellows type dispensing tip, by deforming the deforming wall face.
B65D 83/38 - Réceptacles ou paquets comportant des moyens particuliers pour distribuer leur contenu pour distribution de liquides ou de semi-liquides par pression interne de gaz, c. à d. réceptacles aérosols contenant un propulseur - Détails du corps du récipient
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B65D 37/00 - Réceptacles flexibles transportables non prévus ailleurs
63.
DEVICE FOR AUTOMATING NUCLEIC ACID AMPLIFICATION, AND DEVICE FOR AUTOMATING NUCLEIC ACID AMPLIFICATION ANALYSIS
This device for automating nucleic acid amplification executes a emulsion generation step for including beads to which a nucleic acid is bonded in a water-in-oil type emulsion, a nucleic acid amplification step for amplifying the nucleic acid in the emulsion, an emulsion breaking step for breaking the emulsion, and a purification and concentration step for purifying and concentrating the amplified nucleic acid. The device for automatic nucleic acid amplification has a dispenser unit (20) provided with a dispenser (21) for dispensing solutions and/or reagents to each step, an emulsion unit (30) for executing the emulsion generation step and the emulsion breaking step, a nucleic acid amplification unit (40) for executing the nucleic acid amplification step using the emulsion generated by the emulsion unit (40), and a purification and concentration unit (50) for executing the purification and concentration step using a solution including the amplified nucleic acid obtained by the emulsion breaking step in the emulsion unit (40).
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
64.
Light measurement apparatus for reaction vessel and light measurement method
The invention relates to a method and apparatus for measuring the optical state on the inside of a reaction vessel. The apparatus includes: linking portions that optically connect with the interior of the reaction vessel that is linkable with reaction vessels, a connecting end arranging body having an arranging surface that arranges and supports along a predetermined path, connecting ends to which is provided back ends of the light guide portions, the front ends thereof being provided to the linking portions, the connecting ends being provided to the linking portions; a measurement device having measuring ends that are successively optically connectable with the connecting ends, and in which light based on the optical state is receivable by optical connections between the connecting ends and the measuring ends; and a light guide switching mechanism that successively optically connects the connecting ends and the measuring ends.
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c. à d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
It is an object to provide a deforming element-included dispensing tip, a deforming element-included dispensing device, and a deforming element-included dispensing processing method not requiring any cylinder and capable of achieving highly precise position control and enhancing integration of higher density and reducing the burden in the quality control in reaction processing of a biological material for extraction of DNA and the like. A tip-shaped container formed with a non-deforming wall having an opening portion at an upper side and an inlet unit at a lower side for allowing fluid to flow in and flow out and a sealing plug attached to the opening portion so as to seal the opening portion are provided, and the sealing plug is configured to be provided with a deforming element.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
66.
SOFT STOPPER-PENETRATING PIPETTING DEVICE, AND SOFT STOPPER-PENETRATING PIPETTING METHOD
The present invention pertains to a soft stopper-penetrating pipetting device and a soft stopper-penetrating pipetting method, the purpose thereof being to make possible the suction and discharge of a liquid from a soft stopper-sealed container sealed by a soft stopper of rubber or the like, without the need to remove the soft stopper. The device has: a pipetting-capable piercing head capable of relative motion with respect to a stage on which it is possible to position a soft stopper-sealed container sealed by a soft stopper; a piercing tip provided to the pipetting-capable piercing head, the piercing tip having a passage hole along the vertical direction and being formed to a taper from a hard material; a pipetting needle tip which is movable with respect to the head by a pipetting motion mechanism provided to the pipetting-capable piercing head, and which is capable of suctioning and discharging a liquid; and a controller for controlling at least suction and discharge, the movement of the pipetting-capable piercing head, and the pipetting motion mechanism. The pipetting needle tip and the piercing tip are independently moveable in the vertical direction, the design being such that it is possible for the lower part of the pipetting needle tip to be inserted through the passage hole from the upper side of the piercing tip.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
67.
CHEMILUMINESCENCE MEASUREMENT DEVICE AND METHOD FOR SAME
The present invention relates to a chemiluminescence measurement device and a method for the same, and the purpose of the present invention is to provide a compact, highly reliable chemiluminescence measurement device and a method for the same. The present invention is configured so as to have: a container group; a nozzle head having a gas suction/discharge mechanism, one or more nozzles, to a distal end of which a dispensing tip can be mounted, the nozzles being communicated with the suction/discharge mechanism, and a magnetic force means capable of generating a magnetic field inside a mounted dispensing tip; a connection part provided to the nozzle head and capable of connecting with a reaction container in an opening part thereof, the connection part for forming a closed space shielded from external light by connection with the reaction container; a connection part movement mechanism for enabling the connection part to move relative to the reaction container; a photometer; a shutter for creating a light-guiding state or a light-shielding state between an inside of the reaction container and the photometer in conjunction with connection or disconnection of the connection part with the reaction container; and a reagent injection flow channel whereby a reagent for chemiluminescence can be injected, the reagent injection flow channel being provided to the connection part, and a distal end of the reagent injection flow channel being positioned in the reaction container by connection thereto.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
This culture system (1000) is provided with: a preparatory culture vessel (110) and a main culture vessel (120) that accommodate cells and a solution; a main stage (100) that holds the preparatory culture vessel (110) and the main culture vessel (120); a connecting tube that connects the culture vessels; a valve (173) that opens and closes the connecting tube; and a rotating mechanism (200) that rotates the main stage (100) and imparts a height difference between the culture vessels to transfer the cells and solution by dropping between the culture vessels.
This culture device (10) comprises: a culture container (10) which houses cells, magnetic particles and a culture medium; a temperature adjustment unit (5) for adjusting the temperature of the culture container (10); a magnet (7a) which is provided to the outside of the culture container (10); a magnetic force adjustment unit (7b) for adjusting the magnetic force of the magnet (7a); and a control unit for controlling the operation of the magnetic force adjustment unit (7b). The magnetic force adjustment unit (7b) adjusts the magnetic force of the magnet (7b), thereby holding magnetic particles and cells in a predetermined region within the culture container (10), or dispersing the magnetic particles and cells within the culture container.
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12N 1/00 - Micro-organismes, p.ex. protozoaires; Compositions les contenant; Procédés de culture ou de conservation de micro-organismes, ou de compositions les contenant; Procédés de préparation ou d'isolement d'une composition contenant un micro-organisme; Leurs milieux de culture
C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
The present invention relates to a device and a method for pretreating a sequencer, and addresses the problem of providing a highly reliable pretreatment for analyzing a large-scale nucleotide sequence. A method for pretreating a sequencer comprises: an extraction step of mixing a sample, an extraction reagent solution and a magnetic particle suspension together using a sequencer pretreatment device to extract a nucleic acid, wherein the sequencer pretreatment device is equipped with a suction/ejection mechanism, a nozzle head equipped with a nozzle onto which a dispenser chip is to be mounted in a detachable manner, containers in which various solutions including the magnetic particle suspension are respectively placed, a movement mechanism which can cause the relative movement of the nozzle between the containers, and a magnetic force section which can apply a magnetic field to the inside of the mounted dispenser chip, and wherein the sample, the extraction reagent solution and the magnetic particle suspension are respectively placed in the containers; a fragmentation production step of mixing the nucleic acid with a fragmentation solution placed in some of the containers using the sequencer pretreatment device to fragment the nucleic acid and then producing a fragment having a nucleotide sequence length suitable for the sequencer from the fragmented nucleic acid products using the magnetic particle suspension; and an amplification pretreatment step of dispensing a predetermined volume of a solution containing the produced fragment into each of the reaction containers using the sequencer pretreatment device.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
The purpose of the present invention is to provide a method for analyzing the epigenetic state of stem cells in detail. Provided is a method for identifying stem cells, said method being characterized by comprising analyzing the methylation and demethylation patterns of chromosome DNA that is extracted from stem cells to be inspected, and then relating the patterns thus analyzed to the characteristics of the stem cells to be inspected.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
G01N 37/00 - RECHERCHE OU ANALYSE DES MATÉRIAUX PAR DÉTERMINATION DE LEURS PROPRIÉTÉS CHIMIQUES OU PHYSIQUES - Détails non couverts par les autres groupes de la présente sous-classe
The invention relates to a linear movement type reaction processing device and method for same, the purpose of the invention being to reliably prevent cross-contamination and to reduce work space and decrease work time pertaining to reaction processing. The linear movement type reaction processing device is configured so as to comprise: a container group wherein one or more reaction containers and two or more liquid accommodating sections are arranged in at least one row; a dispensing head which has one or more dispensing tips removably mounted thereon and is capable of relative movement along the row arrangement direction between the dispensing tips when mounted and the container group, said dispensing tips being for drawing in and discharging liquid through their respective distal ends which can be inserted into the reaction containers and the liquid accommodating sections; a magnetic force section which is provided on the dispensing head and can separate the magnetic particles contained in the liquid inside the dispensing tips by exerting a magnetic field within the dispensing tips such that the magnetic particles are attracted to the inner walls thereof, as well as release and re-suspend the attracted magnetic particles into the liquid by removing the magnetic field; and an ultrasonic vibrator which applies, treating at least one liquid accommodating section as a sample accommodating section, ultrasonic vibration to the sample accommodating section.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
74.
ANALYSIS METHOD AND ANALYSIS KIT FOR SIMULTANEOUSLY DETECTING OR QUANTITATING MULTIPLE TYPES OF TARGET SUBSTRANCES
The present invention localizes signal light from probe beads in order to simultaneously detect or quantitate multiple types of target substances. An analysis method for simultaneously detecting or quantitating multiple types of target substances by measuring light emitted by a plurality of carriers which are stored in a single container and on which substances for capturing the multiple types of target substances are immobilized, respectively, from outside the container, wherein light emitted from a desired carrier is selectively received by measuring the light emitted from the carriers through an optical filter. An analysis kit for simultaneously detecting or quantitating multiple types of target substances by measuring light emitted by a plurality of carriers which are stored in a single container and on which substances for capturing the multiple types of target substances are immobilized, respectively, from outside the container, the analysis kit including the plurality of carriers on which the substances for capturing the multiple types of target substances are immobilized, and an optical filter for selectively receiving light emitted from a desired carrier.
G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
DISPENSING TIP WITH BUILT-IN DEFORMING ELEMENT, DISPENSING DEVICE WITH BUILT-IN DEFORMING ELEMENT AND PROCESSING METHOD USING BUILT-IN DEFORMING ELEMENT DISPENSING
The purpose of the present invention is to provide a dispensing tip with a built-in deforming element, a dispensing device with a built-in deforming element and a processing method using built-in deforming element dispensing with which cylinders are unnecessary, highly precise position control is possible, and designing for high density integration and reduction of quality control workload is possible in reaction processing of biological substances such as DNA extraction. The tip: has a tip-shaped container formed with a non-deforming wall having an opening at the upper end and an orifice for inflow and outflow of a fluid at the lower end, and a sealing stopper installed on the opening so as to seal the opening; and is configured so that a deforming element is provided on the sealing stopper, the deforming element having a deforming wall formed so as to be capable of extending downward inside the tip-shaped container as a result of external pressure and to be energized to contract or capable of contracting upward.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01J 4/00 - Dispositifs d'alimentation; Dispositifs de commande d'alimentation ou d'évacuation
G01N 1/00 - Echantillonnage; Préparation des éprouvettes pour la recherche
77.
Automatic light measurement device with a movable mount for coupling with multiple reaction containers
The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have: a container group in which a plurality of reaction containers are arranged; a measurement mount provided with a plurality of coupling ends that are joinable with apertures of the reaction containers, and have light guide portions that optically connect with the interior of the joined reaction containers; a mount transfer mechanism; a measuring device having a measuring end having at least one light guide portion that is optically connectable to the light guide portions of the coupling ends, that is able to receive light based on an optical state within the reaction containers; an on-mount measuring end transfer mechanism; and a measurement control portion.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 21/13 - Transport des cuvettes ou des échantillons solides vers ou à partir de l'emplacement de recherche
G01N 21/31 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
The invention relates to a reaction container and a method for producing the reaction container, and provides a low-cost reaction container which is capable of consistently, quickly, and efficiently performing a process that includes a reaction such as extraction or amplification of a nucleic acid, while saving user's trouble without increasing the scale of the device.
The reaction container is configured to comprise: one or two or more housing parts for reactions comprising: a narrow-mouthed piping part in which a reaction reagent or a portion thereof is housed or is housable; a wide-mouthed piping part that is communicated with the narrow-mouthed piping part and provided on an upper side of the narrow-mouthed piping part, and has an aperture that is wider than an aperture of the narrow-mouthed piping part; and a punchable film provided such that it partitions an interval between the wide-mouthed piping part and the narrow-mouthed piping part.
B65D 6/00 - Réceptacles dont le corps est formé par jonction ou liaison de plusieurs composants rigides ou sensiblement rigides, constitués en totalité ou principalement en métal, en matière plastique, en bois ou en un matériau de remplacement
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
79.
Micro plate treating device and micro plate treating method
An object is to provide a micro plate treating device and micro plate treating method capable of handling a larger number of kinds of solution or suspensions or a larger volume of solutions or suspensions per work area by use of a normalized micro plate without enlarging the scale of the device. The micro plate treating device comprises a micro plate having wells arranged in a matrix form, one or two or more nozzle heads each having nozzles capable of sucking and discharging a fluid and arranged in a matrix form, and moving means capable of moving relatively an interval between the micro plate and the nozzle heads, wherein tips of all the nozzles are configured to be permitted to be simultaneously inserted into some of the wells in the micro plate, at least one of the row interval or the column interval of the nozzles is set to a natural number multiple of the row interval or the column interval of the corresponding wells, the natural number being two or more, and at least one of the row number or the column number of all the corresponding nozzles is one to the natural number of the row number or the column number of the wells.
A light measurement device for a reaction vessel and a light measurement method, whereby the optical state on the inside of a reaction vessel can be measured efficiently and reliably. The light measurement device comprises: a plurality of linking units, each of which can be linked to a reaction vessel and is provided with the anterior end of a light guide unit that optically connects with the interior of the reaction vessel to which the linking unit has been linked; a connection terminal array having an array surface for supporting, in a row along a prescribed path, a plurality of connection terminals, each of which is provided so as to correspond to a linking unit and is provided with the posterior end of a light guide having an anterior end provided to a linking unit; a measurement apparatus that has measurement terminals that can be optically connected to each of the connection terminals in a sequential manner and can receive light when in the optical state achieved by optically connecting a measurement terminal and a connection terminal; and a light-guide switching mechanism for optically connecting the measurement terminals and the connection terminals in a sequential manner.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
Provided are a carrier-enclosed transformable container, a carrier-enclosed transformable container processing apparatus, and a carrier-enclosed transformable container processing method about which a carrier to which various substances such as biogenic substances are bonded or bondable is held in a transformable container as the container to be in a substantially stationary state, thereby making it possible to make the handling of the carrier, measurement, and other treatments effective, speedy, and easy. The container is formed to have: a containing part which can contain liquid and gas at its inside surrounded by a wall face, a part of this wall face having a transformable wall face capable of undergoing a predetermined transformation without changing the entire internal surface area of the wall face substantially; an orifice part which is connected to the containing part and can undergo the inflow and outflow of a liquid sucked and discharged by the expansion and contraction of the inside by the transformation of the transformable wall face, respectively; and a carrier to which a predetermined substance enclosed in the containing part to be in a substantially stationary state is bonded or bondable.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
The invention relates to a carrier enclosing tip, a carrier treating apparatus, and a method of carrier treatment. An object is to perform separation/purification more efficiently and rapidly as compared with treatments using conventional liquid chromatography or filters. There is provided a carrier enclosing tip comprising: a tip-like container having a fitting opening which is fittable to a nozzle for use in gas suction and discharge, or a member to be fitted to a nozzle, and a port through which fluid inflow and outflow can be effected by the gas suction and discharge; and a carrier which is enclosed in the tip-like container, and is capable of adsorbing a biosubstance in the fluid or is capable of reacting with or binding to the biosubstance.
B01D 24/02 - Filtres à substance filtrante non agglomérée, c. à d. à substance filtrante sans aucun liant entre les particules ou les fibres individuelles qui la composent avec le lit filtrant stationnaire pendant la filtration
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
B01D 15/22 - Adsorption sélective, p.ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à la structure de la colonne
C07K 1/16 - Extraction; Séparation; Purification par chromatographie
C07K 1/22 - Chromatographie d'affinité ou techniques analogues basées sur des procédés d'absorption sélective
A various-substance holder, a various-substance holder treating apparatus, and a various-substance holder treating method are provided which enable the mutual identification of particulate carriers to which various substances are or can be immobilized without the need to arrange the particulate carriers at predetermined positions or in a predetermined order, eliminating the need for time and effort to arrange the various substances at predetermined positions or in a predetermined order to allow treatments to be quickly and easily achieved. The various-substance holder has a plurality of particulate carriers or plural sets of particulate carriers to which plural types of chemical substances are or can be immobilized and a carrier holding portion holding the plurality of particulate carriers or the plural sets of particulate carriers in a substantially stationary state such that the plurality of particulate carriers or the plural sets of particulate carriers can be externally measured.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
84.
Automated nucleic acid processor and automated nucleic acid processing method using multi function dispensing unit
In relation to an automated nucleic acid processor and an automated nucleic acid processing method using a multi function dispensing unit, processing involving extraction and amplification of the nucleic acid, can be consistently, quickly and efficiently conducted at a low cost with the use of a multi function dispensing unit, while saving user's trouble without expanding the scale of the device. The multi function dispensing unit includes: a nozzle head provided with a suction-discharge mechanism and nozzles detachably provided with dispensing tips; a container group having, at the very least housing parts for liquids and reaction containers for housing an amplification solution; a transfer mechanism that makes an interval between the nozzles and the container group relatively movable; a temperature controller whereby temperature control of the interior of the reaction vessels is possible; sealing liquids and/or sealing lids that are transportable to the reaction vessels using the nozzles, and which make the amplification solutions housed in the reaction vessels sealable within the reaction vessels; and a sealing control part that controls the suction-discharge mechanism or the transfer mechanism, such that the sealing liquid and/or the sealing lids seal the amplification solution within the reaction vessels when the housing of the amplification solution in the reaction vessels is completed.
G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
The present invention relates to a magnetic reagent, a magnetic reagent kit, a method for treating magnetic carriers, and a treatment device therefor, with an object of quickly and efficiently treating magnetic carriers of a micro particle diameter including nanosized magnetic carriers.
The magnetic reagent or magnetic reagent kit includes: a plurality of magnetic carriers which can be magnetized by being exposed to a magnetic field, can be bonded to a predetermined chemical substance or living organism in a liquid, and that have a particle diameter that enables them to be suspended in the liquid; and a plurality of treatment promoting magnetic particles which can be magnetized by being exposed to a magnetic field and thus can have the magnetic carriers adsorbed on the surface thereof, are formed so that they can be moved within the liquid by movement of the liquid or by a magnetic field, and promote a treatment for capturing or re-suspension of the magnetic carriers.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
B03C 1/015 - Prétraitement spécialement adapté à la séparation magnétique par traitement chimique communiquant des propriétés magnétiques au matériau à séparer, p.ex. grillage, réduction, oxydation
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
87.
OPTICAL MEASUREMENT DEVICE FOR REACTION VESSEL AND METHOD THEREFOR
The present invention relates to an optical measurement device for a reaction vessel, and a method therefor. The purpose of the present invention is to measure the optical state within a reaction vessel in an efficient, rapid, and highly reliable manner, without increasing the scale of equipment. This optical measurement device is configured to comprise: a vessel group in which at least two reaction vessels are arranged; a light guide stand having at least two linking parts which can be linked to each reaction vessel and to which a leading end of a flexible light guide unit optically connected to the interior of a linked reaction vessel is provided; a connection array having an arrangement surface for supporting at least two connection ends to which is provided a rear end of the light guide unit of which the leading end is provided to the linking part, the connection ends being provided so as to correspond to each linking part and being arranged along a predetermined pathway; measuring instruments which are provided so as to be in proximity to or contact with the arrangement surface and have a measurement end capable of optically connecting to each connection end in sequence along the predetermined pathway, the measuring instrument being permitted to receive light from the reaction vessel by the optical connection between the connection end and the measurement end; and a light guide switching mechanism for moving each measurement end and each connection end arranged in the connection array in a relative manner so as to optically connect same in sequence.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A various-substance holder, a various-substance holder treating apparatus, and a various-substance holder treating method are provided which enable the mutual identification of particulate carriers to which various substances are or can be immobilized without the need to arrange the particulate carriers at predetermined positions or in a predetermined order, eliminating the need for time and effort to arrange the various substances at predetermined positions or in a predetermined order to allow treatments to be quickly and easily achieved. The various-substance holder has a plurality of particulate carriers or plural sets of particulate carriers to which plural types of chemical substances are or can be immobilized and a carrier holding portion holding the plurality of particulate carriers or the plural sets of particulate carriers in a substantially stationary state such that the plurality of particulate carriers or the plural sets of particulate carriers can be externally measured.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
The present invention relates to a reaction container and a method for producing the reaction container, and provides a low-cost reaction container which is capable of integrally, quickly and efficiently performing a process that includes a reaction such as extraction or amplification of a nucleic acid, while saving user's trouble without increasing the scale of the device. The reaction container is configured to comprise one or more container units for reaction, each of said container unit comprising: a narrow-mouthed tube part which contains or is capable of containing some or all of a reaction reagent; a wide-mouthed tube part which communicates with the narrow-mouthed tube part and is arranged above the narrow-mouthed tube part, while having an opening that is larger than the opening of the narrow-mouthed tube part; and a perforatable film which is arranged so as to provide a partition between the narrow-mouthed tube part and the wide-mouthed tube part.
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
90.
AUTOMATIC RESPONSE/LIGHT MEASUREMENT DEVICE AND METHOD THEREFOR
The present invention relates to an automatic response/light measurement device and a method therefor, and the purpose of the present invention is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have a container group in which a plurality of reaction containers are arranged, a measurement mount provided with a plurality of coupling ends which are capable of being coupled with the respective opening portions of the reaction containers and have a light guide portion optically connected with the inside of the reaction containers coupled, a mount movement mechanism, a measurement unit which has a measurement end having at least one light guide portion provided on the mount and optically connectable with the light guide portions of the coupling ends and is capable of receiving light based on an optical state in the reaction containers through the measurement end, an on-mount measurement end movement mechanism which causes the measurement end to be movable on the mount, and a measurement control unit which controls the on-mount measurement end movement mechanism to optically connect the light guide portions of the coupling ends with the light guide portion of the measurement end in sequence after controlling the mount movement mechanism so that the coupling ends are coupled with the opening portions of the reaction containers concurrently, to give an instruction of the measurement by the measurement unit.
G01N 21/13 - Transport des cuvettes ou des échantillons solides vers ou à partir de l'emplacement de recherche
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 21/15 - Prévention de la souillure des éléments du système optique ou de l'obstruction du chemin lumineux
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
91.
Optical fiber measurement device and measurement method using same
Disclosed is a highly reliable optical fiber measurement device and measurement method having a simple and compact structure. The device includes a planar liquid holder having a plurality of liquid holding portions arranged along a flat face; a plurality of light receiving optical fibers for transmitting fluorescence generated in the liquid holding portions; a plurality of light emitting optical fibers for transmitting excitation light into the liquid holding portions; a measurement head capable of being positioned in the each liquid holding portion while supporting a plurality of measurement ends having a bundle of one light receiving end of the light receiving optical fibers and one light emitting end of light emitting optical fibers; a light reception selecting element that, by sequentially selecting one by one from plural the light receiving optical fibers and sequentially selecting one by one from plural kinds of wavelength or wavelength bands, sequentially guides the light of the selected wavelength or wavelength band of the fluorescence received by the selected light receiving optical fibers to one photoelectric element; and a photoelectric element for sequentially conducting photoelectric conversion on the guided fluorescence.
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c. à d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
92.
Tube for measuring bio-related substance and quantifying system
A bio-related substance assay tube 2 comprises a target substance capture bead 3 serving as a first microparticle, compensation bead 4 serving as a second microparticle on which a given amount of a bio-related substance has been immobilized, and a negative control bead 5 serving as a third microparticle for use as a negative control. A mount unit 12 comprises a nozzle communicating with a pump, and the bio-related substance assay tube 2 is mounted in the mount unit 12 to ensure communication with this nozzle. An analyte is introduced into the bio-related substance assay tube 2, followed by labeling the bio-related substance bound to each microparticle to cause light emission. Based on light emission from each microparticle, a calibration curve is prepared or the emission intensity of the first microparticle is compensated to quantify the bio-related substance.
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
G01N 21/03 - Dispositions ou appareils pour faciliter la recherche optique - Détails de structure des cuvettes
93.
AUTOMATED NUCLEIC ACID PROCESSOR AND AUTOMATED NUCLEIC ACID PROCESSING METHOD USING MULTI FUNCTION DISPENSING UNIT
The present invention relates to an automated nucleic acid processor and an automated nucleic acid processing method using a multi function dispensing unit. According to the present invention, a processing of a nucleic acid, said processing involving extraction and amplification of the nucleic acid, can be consistently, quickly and efficiently conducted at a low cost with the use of a multi function dispensing unit, while saving user's trouble without expanding the scale of the device. The multi function dispensing unit is configured from: a nozzle head equipped with a suction-discharge mechanism and nozzles detachably provided with dispensing tips; containers at least comprising housing parts for liquids and reaction containers for housing an amplification solution; a transfer mechanism being relatively movable between said nozzles and said containers; a temperature controller being capable of controlling the temperature in said reaction containers: sealing liquids and/or sealing lids being transportable to the reaction containers with the use of the nozzles and enabling seal up of the amplification solution, said amplification solution being housed in the reaction containers, within the reaction containers; and a sealing controller for, after the completion of the housing of the amplification solution in the reaction containers, controlling the suction-discharge mechanism or the transfer mechanism so that the sealing liquids and/or sealing lids ensure the seal up of the amplification solution in the reaction containers.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
Provided is a reagent accommodating/measuring cartridge which mixes and reacts a test sample and a reagent, and measures the reaction state of the mixture by means of the light transmitted, and which is characterised by being provided with a plurality of transmitted light measuring chambers having different optical path lengths.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
95.
COMPOSITION FOR PREVENTING EVAPORATION OF REACTION SOLUTION DURING NUCLEIC ACID AMPLIFICATION REACTION
Provided is a composition that makes it possible to seal a PCR reaction vessel without using a lid or adhesive seal. Specifically provided is: a composition intended to preventing the evaporation of a nucleic acid amplification reaction solution during a nucleic acid amplification reaction, the composition being a liquid during the reaction and becoming a solid, due to chemical change or temperature change, after the reaction; a composition for preventing evaporation of a nucleic acid amplification reaction solution during a nucleic acid amplification reaction, the composition having a fusion point of 0-15C; and a composition for preventing the evaporation of a nucleic acid amplification reaction solution during a nucleic acid amplification reaction, the composition having a fusion point of 5-10C.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
96.
DEVICE FOR TRAPPING BIOLOGICALLY-RELEVANT SUBSTANCES AND SYSTEM FOR COLLECTING BIOLOGICALLY-RELEVANT SUBSTANCES
The disclosed device for trapping biologically-relevant substances can easily collect biologically-relevant substances from a thin tissue section or a gel in which said biologically-relevant substances have been fractionated. Said device is provided with: trapping bodies for trapping biologically-relevant substances; carriers that hold the trapping bodies; and electrodes for charging the trapping bodies. The trapping bodies are charged and brought into contact with a prescribed position on a thin tissue section that contains biologically-relevant substances or a gel in which biologically-relevant substances have been fractionated, thereby trapping said biologically-relevant substances from said gel or thin tissue section.
This invention relates to an assay device and a method for pretreating a specimen containing a biologically-relevant substance and then assaying the biologically-relevant substance. Biologically-relevant substances used in the assay method include microorganisms, cells, viruses, nucleic acids, polysaccharides, proteins (including antigens, antibodies, chromoproteins, and enzymes), peptides, nucleic acids, and small molecules. This pretreatment method removes contaminants from the biologically-relevant substances using supports such as magnetic particles, gels, resins, membranes, and solid-phased reagents. Therefore, in the assay method the following steps are generally carried out (i) a pretreatment step of treating a specimen using one or more first supports and then one or more second supports, and (ii) the assay step carried out after the pretreatment step. In particular, the pretreatment method reduces false positives and false negatives in the assay.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
98.
DISPERSIBLE CARRIER-ENCLOSING FLOW PIPE, PROCESSING DEVICE THEREFOR, AND PROCESSING METHOD
Disclosed are a dispersible carrier-enclosing flow pipe, a processing device therefor, and a processing method, wherein, when a carrier which can target, bind or react is enclosed in a flow pipe, it is possible to efficiently perform treatments, such as reaction and wash treatments, by means of the optimal reactivity and by increasing the uniformity of encounters between a target and the carrier in a liquid as a consequence of suspending or dispersing the carrier in a sucked liquid. A dispersible carrier-enclosing flow pipe is configured to have: a flow pipe through the inside of which and at least in one direction a liquid can flow; a carrier enclosing section disposed so as to partition the inside of the flow pipe into an upstream side and a downstream side; a plurality of dispersible carriers which can absorb, bind with, capture, or react with a biological substance or a living body which were enclosed in the carrier enclosing section in a suspendable or dispersible manner by means of the liquid flow; and a turbulence generating member which is disposed in the vicinity of the upstream side boundary of the carrier enclosing section when a liquid is being introduced to the carrier enclosing section, and which can generate turbulence for dispersing the carrier.
G01N 30/00 - Recherche ou analyse de matériaux par séparation en constituants utilisant l'adsorption, l'absorption ou des phénomènes similaires ou utilisant l'échange d'ions, p.ex. la chromatographie
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
G01N 1/00 - Echantillonnage; Préparation des éprouvettes pour la recherche
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
99.
MAGNETIC REAGENT, MAGNETIC REAGENT KIT, METHOD FOR TREATING MAGNETIC CARRIERS AND TREATMENT DEVICE THEREFOR
Disclosed are a magnetic reagent, a magnetic reagent kit, a method for treating magnetic carriers and a treatment device therefor, whereby magnetic carriers having a minor particle diameter including nano-sized magnetic carriers can be quickly and efficiently treated. The magnetic reagent having a constitution comprising a plurality of magnetic carriers, which can be magnetized by a magnetic field, are capable of binding to a definite chemical or a living organism in a liquid, and have such a particle diameter as being suspendable in said liquid, and a plurality of magnetic particles for promoting a treatment for capturing or re-suspending said magnetic carrier, said magnetic particles being formed so that the particles can be magnetized by a magnetic field and thus adsorbed on the surface of said magnetic carriers and can migrate in said liquid due to the migration of the liquid or the magnetic field.
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/553 - Support métallique ou recouvert d'un métal
