UNIVERSIDADE FEDERAL DO ESTADO DO RIO DE JANEIRO (Brésil)
UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (Brésil)
Inventeur(s)
Macedo Furtado, Andrea
Gabriela Bello Koblitz, Maria
Garrett Da Costa, Rafael
Paula Da Silva Oliveira, Joana
Abrégé
The present invention relates to the production of perfuming, aromatising, taste-enhancing and/or flavouring agents and compositions based on extracts from wild, domesticated and/or modified vanilla fruit from the biodiversity of the Brazilian Atlantic Forest flora, which have a metabolome and proteome that differ from those of the Vanilla planifolia vanilla, generating new vanilla aromas and flavours that can be used in cosmetics, foods, pharmaceuticals and nutraceuticals, perfumes, textiles, wood and plastic articles, repellents and other products that can carry this essence.
This description relates to compounds that inhibit inorganic fouling and corrosion, as well as to the production process for these inhibitor compounds, which are aminoalkyl phosphonates which can be obtained in their protonated chemical form or in their non-protonated chemical form.
HAPISEEDS PESQUISA E DESENVOLVIMENTO LTDA. (Brésil)
UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (Brésil)
Inventeur(s)
Silva Hemerly, Adriana
Da Fonseca Montessoro, Patrícia
Forero Ballesteros, Helkin Giovani
De Oliveira Urquiaga, Maria Clara
Loures Da Silva, Mirielson
Köhn Carneiro, Aline
Cardozo Rosman, Aline
Silva Coelho, Fernanda
Silva De Oliveira, João Victor
Barbosa De Almeida, Janice
Abrégé
The present invention relates to a genetic modification for improving plant characteristics beneficial in agriculture. Specific embodiments provide the use of plants containing said genetic modification, as well as methods for producing plants containing said genetic modification, and plant products obtainable from said plants.
CENTRO DE EDUCAÇÃO FÍSICA ALMIRANTE ADALBERTO NUNES (Brésil)
UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (Brésil)
Inventeur(s)
Dias Pereira, Marcos
Carneiro Da Silva, Andréia
Palmisano, Giuseppe
Abrégé
Methods and kits used in the diagnosis of predisposition to the development of rhabdomyolysis. To perform the invention, a biological sample is withdrawn from an investigated individual, such as a blood or urine sample, preferably urine. The investigation is conducted from the detection and quantification of proteins in said sample, proteins selected from a panel that includes: cathepsin H; alpha-1 collagen chain (I); phosphatidylinositol-3-kinase interaction protein 1; beta-defensin 1; integrin beta-1; Brevican core protein; a member of the tumor necrosis factor receptor superfamily 10C; gamma-glutamylcyclotransferase; Glutaredoxin, Flavin reductase; Desmocollin-2; Alpha-1 collagen chain (I); Sodium/nucleoside cotransporter 1; Uteroglobin; Hemoglobin alpha subunit; Hemicentin-1; CCN family member 3; Parkinson's disease protein 7; Intercellular adhesion molecule 2; Secreted Ly-6/uPAR-related protein 1; N-acetylmuramoyl-L-alanine amidase; Cathepsin Z; Fatty acid-binding protein 5; Atractin; Peptidyl-prolyl cis-trans isomerase A and heart fatty acid-binding protein.
G01N 33/573 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour enzymes ou isoenzymes
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
5.
COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE
Consejo Nacional de Investigaciones Cientificas y Técnicas (Argentine)
Universidade Federal do Rio de Janeiro (Brésil)
Inventeur(s)
Klein, William L.
Jerusalinsky, Diana
Ferreira, Sergio T.
Selles, Maria Clara
Sebollela, Adriano S.
Abrégé
Provided herein are antibodies against amyloid-beta (Aβ) oligomers, and methods of use thereof for the treatment of Alzheimer's disease (AD). In particular, neauronal expression of single-chain variable fragment (scFv) antibodies against Aβ oligomers is provided as a therapeutic approach in the treatment of AD.
The invention is part of methods for separating microorganisms from their culture media and aims at solving the low efficiency and high environmental impact of processes for recovering oil-producing microalgae. For this purpose, the invention provides for the application of magnetic nanoparticles of bacterial origin (NMOBs) in processes for isolating microalgae from a cell culture or from a suspension of salt water or an effluent. NMOBs are particularly capable of recovering microalgae from hypersaline suspensions, favoring the use of marine microalgae in the production of oils with potential application in bio-oil and biofuel production processes. In addition to the use of NMOBs, the invention also provides for a process for recovering microalgae based on the addition of NMOBs to the microalgae suspension and subsequent application of external magnetic force.
Centre national de la recherche scientifique (France)
Université de Strasbourg (France)
Universidade Federal do Rio de Janeiro (Brésil)
Inventeur(s)
Louis, Benoit
Bingre, Rogeria
Megias Sayago, Cristina
Maciel Pereira, Marcelo
Gomes Flores, Camila
Abrégé
The present invention relates to a process for preparing a zeolite ZSM-5 presenting a Si/Al molar ratio comprised between 2 and 8, preferably between 3 and 8, comprising the following steps: a) mixing at least one silicon source, at least one aluminum source, at least one organic template and at least one aqueous solvent, in order to obtain a synthesis mixture in solution or gel form; b) ageing the mixture obtained in step a) at a temperature of between 20° C. and 200° C. during at least 30 minutes; and d) crystallizing the resulting mixture during at least 24 hours, wherein a step c) of adding wood lignin or oxidized wood lignin to the mixture is performed after step a) or after step b). It also relates to a zeolite which is obtainable by such a process, and to its use.
C07C 1/24 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure à partir de composés organiques ne renfermant que des atomes d'oxygène en tant qu'hétéro-atomes par élimination d'eau
UNIVERSIDADE FEDERAL DO ESTADO DO RIO DE JANEIRO (Brésil)
UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (Brésil)
Inventeur(s)
Furtado Macedo, Andrea
Gabriela Bello Koblitz, Maria
Garrett Da Costa, Rafael
Paula Da Silva Oliveira, Joana
Abrégé
Vanilla planifoliaVanilla planifolia vanilla, generating new vanilla aromas and flavours that can be used in cosmetics, foods, pharmaceuticals and nutraceuticals, perfumes, textiles, wood and plastic articles, repellents and other products that can carry this essence.
CENTRO DE EDUCAÇÃO FÍSICA ALMIRANTE ADALBERTO NUNES (Brésil)
UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (Brésil)
Inventeur(s)
Dias Pereira, Marcos
Carneiro Da Silva, Andréia
Palmisano, Giuseppe
Abrégé
Methods and kits are described for diagnosing a predisposition to develop rhabdomyolysis. To implement the invention, a biological sample is taken from an investigated individual, such as a blood or urine sample, preferably urine. The investigation is performed by detecting and quantifying in the sample proteins selected from a panel comprising: cathepsin H (CTSH); a collagen alpha-1 chain (I) (COL1A1); phosphatidylinositol-3-kinase-interacting protein 1 (PIK3IP1); beta-defensin 1 (DEFB1); integrin beta-1 (ITGB1); Brevican core protein (BCAN); a member of the tumor necrosis factor receptor superfamily 10C (TNFRST10C); gamma-glutamyl cyclotransferase (GGCT); glutaredoxin (GLRX); flavin reductase (NADPH) (BLVRB); desmocollin-2 (DSC2); a collagen alpha 1 chain (I) (COL1A1); sodium/nucleoside 1 cotransporter (S28A1); uteroglobin (UTER); haemoglobin alpha subunit (HBA); hemicentin-1 (HMCN1); a member of the CCN3 (CCN3) family; Parkinson disease protein 7 (PARK7); intercellular adhesion molecule-2 (ICAM2); secreted Ly-6/uPAR-related protein 1 (SLURP1); N-acetylmuramoyl-L-alanine amidase (PGRP2); cathepsin Z (CATZ); fatty acid-binding protein 5 (FABP5); attractin (ATRN); peptidyl-prolyl cis-transisomerase A (PPIA); and heart-type fatty acid-binding protein (FABP3).
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
10.
HIGH-PRESSURE VESSEL FOR PACKAGING HOLLOW FIBER TYPE MEMBRANES FOR THE SEPARATION PROCESS WITH CONTACTORS
The present invention addresses to a high-pressure vessel for packaging hollow fiber type membranes with application in the field of separation process with contactors with membranes aiming at a compact device/piece of equipment configured for the packaging of hollow fiber type bundles that can be used for various fluid separation processes such as liquid-liquid, liquid-gas and gas-gas, capable of working at high-pressures, enabling adequate hydrodynamic conditions and easily scalable. It is called a module the general piece of equipment, consisting of the vessel (A or C), object of the present invention, and the membranes packed inside the vessel. This piece of equipment consists of a vessel inside which the membranes are placed (14), and two heads attached at the ends (B or D). Each head has two connection points, thus allowing this device to be used with membrane contactors-type separation systems, such as “classical” permeation systems (liquid-liquid, gas-gas, pervaporation).
The present invention relates to a prediction-based technique for encoding light field data by removing redundant information of light field data, reducing a number of bits by employing a prediction of a pixel value in all four dimensions of the light field. Using this technique to represent light field data, allows it to be transferred through a limited-bandwidth medium and/or to significantly reduce the required storage capacity for this purpose.
H04N 19/593 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage prédictif mettant en œuvre des techniques de prédiction spatiale
H04N 19/186 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage adaptatif caractérisés par l’unité de codage, c.-à-d. la partie structurelle ou sémantique du signal vidéo étant l’objet ou le sujet du codage adaptatif l’unité étant une couleur ou une composante de chrominance
H04N 19/176 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage adaptatif caractérisés par l’unité de codage, c.-à-d. la partie structurelle ou sémantique du signal vidéo étant l’objet ou le sujet du codage adaptatif l’unité étant une zone de l'image, p. ex. un objet la zone étant un bloc, p. ex. un macrobloc
H04N 19/597 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage prédictif spécialement adapté pour l’encodage de séquences vidéo multi-vues
H04N 19/11 - Sélection du mode de codage ou du mode de prédiction parmi plusieurs modes de codage prédictif spatial
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITÉ DE STRASBOURG (France)
UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (Brésil)
Inventeur(s)
Louis, Benoit
Bingre, Rogeria
Megias Sayago, Cristina
Maciel Pereira, Marcelo
Gomes Flores, Camila
Abrégé
The present invention relates to a process for preparing a zeolite ZSM-5 presenting a Si / Al molar ratio comprised between 2 and 8, preferably between 3 and 8, comprising the following steps: a) mixing at least one silicon source, at least one aluminum source, at least one organic template and at least one aqueous solvent, in order to obtain a synthesis mixture in solution or gel form; b) ageing the mixture obtained in step a) at a temperature of between 20°C and 200°C during at least 30 minutes; and d) crystallizing the resulting mixture during at least 24 hours, wherein a step c) of adding wood lignin or oxidized wood lignin to the mixture is performed after step a) or after step b). It also relates to a zeolite which is obtainable by such a process, and to its use.
Equipment for measurement of the contribution to frequency stability by a generating unit, especially for generating units based on power electronics. This equipment is to be installed between a generating unit and an electric power system. It emulates an electric power system undergoing a power unbalance, which manifests itself through a grid frequency swing.
G01R 27/28 - Mesure de l'atténuation, du gain, du déphasage ou des caractéristiques qui en dérivent dans des réseaux électriques quadripoles, c.-à-d. des réseaux à double entréeMesure d'une réponse transitoire
G01R 23/02 - Dispositions pour procéder à la mesure de fréquences, p. ex. taux de répétition d'impulsionsDispositions pour procéder à la mesure de la période d'un courant ou d'une tension
G01R 27/32 - Mesure de l'atténuation, du gain, du déphasage ou des caractéristiques qui en dérivent dans des réseaux électriques quadripoles, c.-à-d. des réseaux à double entréeMesure d'une réponse transitoire dans des circuits comportant des constantes réparties
G01R 31/28 - Test de circuits électroniques, p. ex. à l'aide d'un traceur de signaux
Described are methods for promoting increase in plant biomass and yield. This increase has its visible effects in organs such as leaf, stem, root and production of fruits and seeds. Further described is the increase in tolerance of those plants to drought, generating plants better adapted to the environmental changes, improving their growth, biomass and yield.
A method for compressing light field data using variable block-size four-dimensional transform and bit-plane hexadeca-tree decomposition, the method including: partitioning a four-dimensional pixel data of a light field into four-dimensional blocks of independent fixed size; partitioning the four-dimensional blocks in a set of four-dimensional non-overlapping sub-blocks of different sizes according to a rate-distortion criterion; independently transforming the four-dimensional sub-blocks generated in the previous operation, using a four-dimensional transform; quantizing by bit-planes the sub-blocks transformed by the four-dimensional transform according to Rate-Distortion optimized hexadeca-tree structure; and encoding the four-dimensional quantized data generated through an arithmetic encoder to produce a compressed representation of the light field.
H04N 19/176 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage adaptatif caractérisés par l’unité de codage, c.-à-d. la partie structurelle ou sémantique du signal vidéo étant l’objet ou le sujet du codage adaptatif l’unité étant une zone de l'image, p. ex. un objet la zone étant un bloc, p. ex. un macrobloc
H04N 19/147 - Débit ou quantité de données codées à la sortie du codeur selon des critères de débit-distorsion
LIPOSOMAL FORMULATION, PHARMACEUTICAL COMPOSITION, USE OF A LIPOSOMAL FORMULATION, METHOD FOR TREATING CANCER, AND PROCESS FOR PREPARING A LIPOSOMAL FORMULATION
The present invention relates to liposomal formulations comprising enzymes with asparaginase activity covalently linked to the ends of polyethylene glycol molecules exposed on the surface of liposomes. The liposomal formulations described herein can be used for treating cancer, particularly leukemias.
A61K 38/50 - Hydrolases (3) agissant sur des liaisons carbone-azote autres que des liaisons peptidiques (3.5), p. ex. asparaginase
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
Polymer compositions may include a polymer matrix containing a polyolefin, one or more polymer particles dispersed in the polymer matrix, wherein the one or more polymer particles include a polar polymer selectively crosslinked with a crosslinking agent, and wherein the one or more polymer particles has an average particle size of up to 200 μm. Processes of preparing a polymer composition may include mixing a polyolefin, a polar polymer, and a crosslinking agent; and selectively crosslinking the polar polymer with the crosslinking agent in the presence of the polyolefin. Methods may include increasing stress cracking resistance of a polyolefin by mixing a polar polymer with the polyolefin; and selectively crosslinking the polar polymer in the presence of the polyolefin with a crosslinking agent to form crosslinked polar polymer particles dispersed in the polyolefin.
C08L 29/00 - Compositions contenant des homopolymères ou des copolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, chacun ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un radical alcool, éther, aldéhyde, cétone, acétal ou cétalCompositions contenant des polymères d'esters hydrolysés d'alcools non saturés avec des acides carboxyliques saturésCompositions contenant des dérivés de tels polymères
C08L 51/06 - Compositions contenant des polymères greffés dans lesquels le composant greffé est obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carboneCompositions contenant des dérivés de tels polymères greffés sur des homopolymères ou des copolymères d'hydrocarbures aliphatiques ne contenant qu'une seule liaison double carbone-carbone
C08J 3/00 - Procédés pour le traitement de substances macromoléculaires ou la formation de mélanges
C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
18.
Polyolefin compositions with improved mechanical and barrier properties
Polymer compositions may include a polymer matrix containing a polyolefin, one or more polymer particles dispersed in the polymer matrix, wherein the one or more polymer particles include a polar polymer selectively crosslinked with a crosslinking agent, and wherein the one or more polymer particles has an average particle size of up to 200 μm. Processes of preparing a polymer composition may include mixing a polyolefin, a polar polymer, and a crosslinking agent; and selectively crosslinking the polar polymer with the crosslinking agent in the presence of the polyolefin. Methods may include increasing stress cracking resistance of a polyolefin by mixing a polar polymer with the polyolefin; and selectively crosslinking the polar polymer in the presence of the polyolefin with a crosslinking agent to form crosslinked polar polymer particles dispersed in the polyolefin.
C08L 29/00 - Compositions contenant des homopolymères ou des copolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, chacun ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un radical alcool, éther, aldéhyde, cétone, acétal ou cétalCompositions contenant des polymères d'esters hydrolysés d'alcools non saturés avec des acides carboxyliques saturésCompositions contenant des dérivés de tels polymères
C08L 51/06 - Compositions contenant des polymères greffés dans lesquels le composant greffé est obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carboneCompositions contenant des dérivés de tels polymères greffés sur des homopolymères ou des copolymères d'hydrocarbures aliphatiques ne contenant qu'une seule liaison double carbone-carbone
C08J 3/00 - Procédés pour le traitement de substances macromoléculaires ou la formation de mélanges
C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
19.
CONNECTION FITTING FOR A FLEXIBLE PIPE AND ASSOCIATED ASSEMBLY METHOD
The invention relates to a connection fitting for a flexible pipe (10) for transporting fluid. The flexible pipe (10) comprises at least one tubular sheath (20) and at least one layer (24, 25) of tensile armour arranged on the outside with respect to the tubular sheath (20), the layer of armour (24, 25) comprising a plurality of wire-like armour elements (29). The fitting comprises at least one end portion of each armour element, an end dome and a cap fixed to the end dome, the end dome and the cap defining between one another a chamber for receiving each end portion, the receiving chamber being filled with a filler material. The filler material is an epoxy resin comprising carbon nanotubes chemically bonded to the epoxy resin. Such a fitting has improved axial tension recovery and reduced risk of fatigue failure.
F16L 11/08 - Manches, c.-à-d. tuyaux flexibles en caoutchouc ou en matériaux plastiques flexibles avec armature noyée dans la paroi
F16L 33/01 - Dispositions d'assemblage des manches avec des organes rigidesRaccords rigides pour manches, p. ex. éléments unitaires s'engageant à la fois dans deux manches spécialement adaptées pour des manches ayant une paroi à plusieurs couches
F16L 33/34 - Dispositions d'assemblage des manches avec des organes rigidesRaccords rigides pour manches, p. ex. éléments unitaires s'engageant à la fois dans deux manches avec une liaison obtenue par vulcanisation, collage, fusion ou similaire
C08L 63/00 - Compositions contenant des résines époxyCompositions contenant des dérivés des résines époxy
20.
NON-AGGLOMERATING BIOCONJUGATES OF AMYLIN AND AMYLIN-MIMETIC COMPOUNDS, COMPOSITIONS COMPRISING THE SAME, AND MAKING AND USE THEREOF
The present disclosure concerns non-agglomerating bioconjugates of amylin, amylin-mimetic compounds, and combinations comprising the same, wherein said bioconjugate contains at least one acyl unit. Methodology of making and using are provided herein. In some embodiments, an instant non-agglomerating amylin bioconjugate can be used for treating a disease associated with a lack of natural production of amylin and/or deposition or accumulation of extracellular amyloid fibers, which contribute to the dysfunction or failure of systemic organs such as the pancreas or the brain.
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
A61P 5/48 - Médicaments pour le traitement des troubles du système endocrinien des hormones pancréatiques
A61P 5/50 - Médicaments pour le traitement des troubles du système endocrinien des hormones pancréatiques pour augmenter ou potentialiser l'activité de l'insuline
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
21.
Gravitation anchor for offshore anchoring of ships and platforms
The present invention is related to a gravitation anchor for offshore anchoring of ships and platforms, comprising a main body (10) with a longitudinal axis of revolution (11), comprising a means of stabilization (14), whereby the means of stabilization (14) comprises a means of automatic activation (140). Optionally, the means of stabilization comprises at least one stabilizer (14), whereby each stabilizer (14) comprises an end pivotally attached (141) to the gravitation anchor (1), and a free end, whereby when the stabilizer (14) is in a retracted position, the free end is positioned closer to the main body (10) of the gravitation anchor (1), and whereby when the stabilizer (14) is in an extended position, the free end is positioned away from the main body (10) of the gravitation anchor (1).
The present invention describes a photochemical hydrogenation process for heavy fractions of hydrocarbon streams where the aromatic and polyaromatic compounds present in that fraction selectively react in the presence of an alkoxide, when subjected to electromagnetic irradiation.
C07C 5/10 - Préparation d'hydrocarbures à partir d'hydrocarbures contenant le même nombre d'atomes de carbone par hydrogénation de cycles aromatiques à six chaînons
B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
C07D 487/22 - Composés hétérocycliques contenant des atomes d'azote comme uniques hétéro-atomes dans le système condensé, non prévus par les groupes dans lesquels le système condensé contient au moins quatre hétérocycles
23.
PHOTOCHEMICAL HYDROGENATION OF HEAVY FRACTIONS OF HYDROCARBON STREAMS
The present invention describes a photochemical hydrogenation process for heavy fractions of hydrocarbon streams where the aromatic and polyaromatic compounds present in that fraction selectively react in the presence of an alkoxide, when subjected to electromagnetic irradiation.
C10G 49/18 - Traitement des huiles d'hydrocarbures, en présence d'hydrogène ou de composés donneurs d'hydrogène, non prévu dans un seul des groupes , , , ou en présence de composés donneurs d'hydrogène, p. ex. d'ammoniac, d'eau, de sulfure d'hydrogène
24.
POLYOLEFIN COMPOSITIONS WITH IMPROVED MECHANICAL AND BARRIER PROPERTIES
Polymer compositions may include a polymer matrix containing a polyolefin, one or more polymer particles dispersed in the polymer matrix, wherein the one or more polymer particles include a polar polymer selectively crosslinked with a crosslinking agent, and wherein the one or more polymer particles has an average particle size of up to 200 µm. Processes of preparing a polymer composition may include mixing a polyolefin, a polar polymer, and a crosslinking agent; and selectively crosslinking the polar polymer with the crosslinking agent in the presence of the polyolefin. Methods may include increasing stress cracking resistance of a polyolefin by mixing a polar polymer with the polyolefin; and selectively crosslinking the polar polymer in the presence of the polyolefin with a crosslinking agent to form crosslinked polar polymer particles dispersed in the polyolefin.
C08L 23/00 - Compositions contenant des homopolymères ou des copolymères d'hydrocarbures aliphatiques non saturés ne possédant qu'une seule liaison double carbone-carboneCompositions contenant des dérivés de tels polymères
25.
Polyolefin compositions with improved mechanical and barrier properties
Polymer compositions may include a polymer matrix containing a polyolefin, one or more polymer particles dispersed in the polymer matrix, wherein the one or more polymer particles include a polar polymer selectively crosslinked with a crosslinking agent, and wherein the one or more polymer particles has an average particle size of up to 200 μm. Processes of preparing a polymer composition may include mixing a polyolefin, a polar polymer, and a crosslinking agent; and selectively crosslinking the polar polymer with the crosslinking agent in the presence of the polyolefin. Methods may include increasing stress cracking resistance of a polyolefin by mixing a polar polymer with the polyolefin; and selectively crosslinking the polar polymer in the presence of the polyolefin with a crosslinking agent to form crosslinked polar polymer particles dispersed in the polyolefin.
C08L 29/00 - Compositions contenant des homopolymères ou des copolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, chacun ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un radical alcool, éther, aldéhyde, cétone, acétal ou cétalCompositions contenant des polymères d'esters hydrolysés d'alcools non saturés avec des acides carboxyliques saturésCompositions contenant des dérivés de tels polymères
C08L 51/06 - Compositions contenant des polymères greffés dans lesquels le composant greffé est obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carboneCompositions contenant des dérivés de tels polymères greffés sur des homopolymères ou des copolymères d'hydrocarbures aliphatiques ne contenant qu'une seule liaison double carbone-carbone
C08J 3/00 - Procédés pour le traitement de substances macromoléculaires ou la formation de mélanges
C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
The invention relates to a high-density magnetic storage medium provided with low-symmetry ferromagnetic particles, wherein said particles are formed by segments or bars, or systems of bars and combinations of said bars which form structures of different geometries.
G11C 11/02 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments magnétiques
G11C 11/10 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments magnétiques utilisant des éléments d'emmagasinage multi-axiaux
G11C 11/56 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments d'emmagasinage comportant plus de deux états stables représentés par des échelons, p. ex. de tension, de courant, de phase, de fréquence
G11C 15/02 - Mémoires numériques dans lesquelles l'information, comportant une ou plusieurs parties caractéristiques, est écrite dans la mémoire et dans lesquelles l'information est lue au moyen de la recherche de l'une ou plusieurs de ces parties caractéristiques, c.-à-d. mémoires associatives ou mémoires adressables par leur contenu utilisant des éléments magnétiques
G11C 19/08 - Mémoires numériques dans lesquelles l'information est déplacée par échelons, p. ex. registres à décalage utilisant des éléments magnétiques utilisant des couches minces dans une structure plane
B82Y 25/00 - Nanomagnétisme, p. ex. magnéto-impédance, magnétorésistance anisotropique, magnétorésistance géante ou magnétorésistance à effet tunnel
27.
SAMPLING DEVICE FOR SOFT AND VERY SOFT SOILS WITH CABLE-ACTUATED JAWS AND SOIL FLOW BETWEEN THE JAWS AND THE SAMPLING TUBE
As described in the description and depicted in the drawings, the present utility model application relates to a structural arrangement for devices for collecting superficial and deep samples of soft and very soft soils. More specifically, a sampling device is provided with a cutting-holding mechanism having the shape of a perfectly spherical cap with jaw-like blades connected thereto, designed to cut the sample at the end of the thrust-in process, in such a way that the sample is not pushed into the sampling device and is prevented from slipping, ensuring that the sample can be retrieved and minimising squashing effects both while the sampling device is thrust in and while the sample is retrieved.
The present invention relates to a method for promoting an increase in plant biomass and productivity. Said increase has visible effects in organs such as leaves, stems and roots, and on seed and fruit production. Moreover, the invention can increase drought resistance in said plants.
The present invention generally concerns new non-agglomerating bioconjugates of amylin-mimetic compounds with polyethylene glycol, and their use mainly in the treatment of diseases associated with extracellular amyloid deposition or accumulation that contributes to the dysfunction or failure of systemic organs such as the pancreas.
A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament
C07K 1/113 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs sans changement de la structure primaire
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
A61P 5/48 - Médicaments pour le traitement des troubles du système endocrinien des hormones pancréatiques
A61P 5/50 - Médicaments pour le traitement des troubles du système endocrinien des hormones pancréatiques pour augmenter ou potentialiser l'activité de l'insuline
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
30.
2-CHLORO-4-ANILINO-QUINAZOLINE COMPOUNDS INHIBITING PROTEIN TYROSINE KINASES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, METHOD FOR PRODUCING THE SAME AND TYROSINE KINASE INHIBITION METHOD
The present invention relates to 2-chloro-4-anilino-quinazoline derivatives with EGFR and/or VEGFR-2 protein tyrosine kinase inhibiting activity, to anti-tumour pharmaceutical compositions that comprise said compounds, and to methods for producing the same. The present invention further provides a method for treating solid tumours by inhibition of tyrosine kinases.
The present invention relates to new organic molecules with bathochromic solvatochromism that can be used in fluorescent compositions, and to the method for synthesizing said organic molecules, to the treatment of objects in order to incorporate both organic and inorganic fluorescent substances and non-fluorescent substances into the structure of said objects, and to methods that allow subsequent identification and authentication of the object provenance by means of analytical techniques in order to obtain information relating to the manufacturer, origin, batch, model or serial number.
C07C 211/61 - Composés contenant des groupes amino liés à un squelette carboné ayant des groupes amino liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné ayant des groupes amino liés à des atomes de carbone de cycles aromatiques à six chaînons faisant partie de systèmes cycliques condensés du squelette carboné avec au moins un des systèmes cycliques condensés formé par trois cycles ou plus
C07C 209/68 - Préparation de composés contenant des groupes amino liés à un squelette carboné à partir d'amines, par des réactions n'impliquant pas de groupes amino, p. ex. réduction d'amines non saturées, aromatisation ou substitution du squelette carboné
32.
METHOD FOR DETECTING BASIC ADDITIVES IN FUELS AND LUBRICATION OILS, AND KIT FOR CARRYING OUT THE METHOD
The present invention describes a method for detecting basic additives in fuels and lubrication oils, and a kit for carrying out the method. The method detects detergent or dispersing additives in fluid hydrocarbons containing same, preferably fuels and lubrication oils containing these additives, by detecting differences in chromatographic behaviour. This is possible because the detergent or dispersing additives are polar and basic in nature, while fuels (gasoline and diesel oil) and basic lubrication oils essentially are hydrocarbons. The monitoring method of the present invention is simple, inexpensive, reliable and easy to apply, and can be used by consumers, inspection authorities, producers or distributors.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
HYDRAZIDE-N-ACYLHYDRAZONE COMPOUNDS, METHOD FOR PRODUCING HYDRAZIDE-N-ACYLHYDRAZONE COMPOUNDS, USE OF INTERMEDIATE COMPOUNDS FOR PRODUCING HYDRAZIDE-N-ACYLHYDRAZONES FOF THE TREATMENT OF LEISHMANIASIS AND CHAGAS DISEASE, AND THUS OBTAINED PHARMACEUTICAL COMPOSITIONS
The invention relates to hydrazide-N-acylhydrazone compounds, to a method for producing hydrazide-N-acylhydrazone compounds, to the use of intermediate compounds for producing hydrazide-N-acylhydrazones for the treatment of leishmaniasis and Chagas disease, and to the thus obtained pharmaceutical compositions. The invention describes, in particular, the production of leishmanicidal and/or trypanocidal compounds that inhibit the cysteine proteinases involved in infectious processes caused by parasites of the Trypanossoma cruzi and Leishmania species. In other words, the invention relates to the development of the series of hydrazide-N-acylhydrazone compounds aimed at providing an active principle for pharmaceutical compositions for the treatment of the various clinical forms of leishmaniasis and Chagas disease; to the development of the series of functionalised hydrazide-N-acylhydrazone derivatives (series III and IV), achieved by molecular hybridization between the LASSBio-1111 (leishmanicidal) prototype and the LASSBio-1064 (trypanocidal) prototype by hybridisation of the aryl-hydrazide subunit of LASSBio-1111 with the functionalised acylhydrazone of LASSBio-1064, producing a new molecular pattern that conjugates leishmanicidal and/or trypanocidal properties.
C07C 281/14 - Composés contenant l'un des groupes p. ex. semicarbazides l'autre atome d'azote étant lié de plus par une liaison double à un atome de carbone, p. ex. semicarbazones l'atome de carbone étant lié de plus à un atome de carbone d'un cycle aromatique à six chaînons
A61K 31/175 - Amides, p. ex. acides hydroxamiques ayant le groupe N-C(O)-N ou N-C(S)-N, p. ex. urée, thiourée, carmustine ayant le groupe , N-C(O)-N=N- ou , p. ex. carbonohydrazides, carbazones, semicarbazides, semicarbazonesLeurs thio-analogues
EMPRESA BRASILEIRA DE PESQUISA AGROPECUÁRIA (Brésil)
Inventeur(s)
Ferreira, Marcio Alves
Artico, Sinara
Lambret Frotté Silva, Julia
Muniz Nardeli, Sarah
Grossi De Sá, María Fátima
Abrégé
The present invention relates to promoters of the expression of specific plant genes. More specifically, the present invention provides a nucleotide sequence for the expression of genes of interest in flowers and fruit of Gossypium hirsutum, in order to produce genetically modified plants that are resistant to the attack of pests such as boll weevil (Anthonomus grandis). In particular, the present invention describes DNA constructs that contain promoters of the genes of interest for creating genetically modified plants, as well as a method for modifying gene expression.
EMPRESA BRASILEIRA DE PESQUISA AGROPECUARIA—EMBRAPA (Brésil)
Inventeur(s)
Alves Ferreira, Marcio
Pinheiro Da Cruz Waltenberg, Fernanda
Romano De Campos Pinto, Eduardo
Grossi De Sa, Maria Fatima
Abrégé
Coffea Arabica species), belonging to the HD-Zip family, and characterized by a homeodomain associated with a leucine zipper. The expression of this transcriptional factor is induced in leaves and roots of coffee plants subjected to various water deficit conditions (both moderate and severe); transgenic plants that over-express this gene inhibiting greater tolerance both to differ drought intensities and to high salt concentrations.
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
36.
METHOD FOR PRODUCING POLY(ETHYLENE FURAN-2,5-DICARBOXYLATE)-BASED RESINS, POLY(ETHYLENE FURAN-2,5-DICARBOXYLATE)-BASED RESINS, AND THE USE OF SAID RESINS
The present invention relates to a method for producing poly(ethylene furan-2,5-dicarboxylate)-based resins, the method involving the polymerisation of poly(ethylene furan-2,5-dicarboxylate) in the presence of ethylene glycol, to the poly(ethylene furan-2,5-dicarboxylate)-based resins, and to the use of said resins for manufacturing films, packaging, fibres and extruded parts.
The invention provides a defined low protein culture medium for maintaining cells in an undifferentiated state, the medium comprising: a basal medium, an organic acid from the tricarboxylic acid cycle, nonessential amino acids, a combination of growth factors selected from the group consisting of FGF-2 protein, an IGF-1 protein or insulin, a Transferrin protein, and a TGF beta 1 protein, wherein the medium is essentially feeder-free, essentially xeno-free, essentially free of beta-mercaptoethanol, and essentially free of animal-derived or human-derived proteins.
INITIATORS, METHOD AND KIT FOR THE DIFFERENTIAL DIAGNOSIS OF CROHN´S DISEASE AND ULCERATIVE RECTOCOLITIS BY MEANS OF IMMUNOHISTOCHEMICAL LABELLING OF THE PROTEINS B-CATENIN AND RETINOBLASTOMA
The present invention relates to the development of a kit that uses specific initiators for carrying out an immunohistochemical labelling assay of the β-catenin and retinoblastoma (RB) proteins in preferably paraffinized colon biopsies from patients with chronic inflammatory bowel diseases.
G01N 33/567 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet utilisant un support spécifique ou des protéines réceptrices comme réactifs pour la formation de liaisons par ligand utilisant un extrait de tissu ou d'organe comme agent de liaison
39.
BIOACTIVE FRACTION OF TEREDINIBACTER TURNERAE BACTERIA CULTURE, METHOD FOR OBTAINING THE BIOACTIVE FRACTION, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISEASES AND DISORDERS
The invention pertains to the field of pharmaceutical drugs, more precisely, it relates to a bioactive fraction obtained from Teredinibacter turnerae bacteria. This fraction can be used in a pharmaceutical composition for the treatment of cellular and viral proliferative diseases and disorders, including retroviral infections such as with HIV, or with an RNA virus, such as Dengue virus, or with a DNA virus. Moreover, the bioactive fraction can be adsorbed in cellulose particles, and can thus be applied to specific tissues without being dispersed.
Leishmania DNA, aiming to stave off the spread of the parasite which causes canine visceral leishmaniasis in dog to the insect transmitter, thus to other dogs and humans. The invention also comprises also the use of the aforementioned composition to produce formulations designed to treat canine visceral leishmaniasis and visceral and murine tegumentary leishmaniasis, human and canine, as well as a kit comprising immune chemotherapeutic agents to treat the same diseases.
A61K 31/706 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle
41.
MAIN IMMUNOPROTECTIVE DOMAINS AND EPITOPES OF NUCLEOSIDE HYDROLASE FROM LEISHMANIA (L) DONOVANI FOR USE IN VACCINATION, IMMUNOTHERAPY AND DIAGNOSIS
The present innovation relates to the identification of the main sequences of the protein nucleoside hydrolase from Leishmania (L) donovani, to be included in a recombinant, DNA or synthetic vaccine to protect and cross-protect against leishmanioses. It also relates to the identification of the main epitopes that react with antibodies to be used in the immunodiagnosis of leishmanioses, and to the use thereof to give cross-protection against other micro-organisms having a sequence in common in the nucleoside hydrolases thereof.
C07K 14/44 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de protozoaires
EMPRESA BRASILEIRA DE PESQUISA AGROPECUARIA EMBRAPA (CENARGEN) (Brésil)
Inventeur(s)
Alves Ferreira, Marcio
Pinheiro Da Cruz Waltenberg, Fernanda
Romano De Campos Pinto, Eduardo
Grossi De Sá, Maria Fátima
Abrégé
The proposed innovation relates to the biotechnological improvement of plant species of commercial interest. More specifically, the present invention relates to the production of transgenic plants with greater tolerance to water scarcity and salt stress by means of the expression of a new gene of coffee (of the Coffea arabica species), belonging to the HD-Zip family, and characterised by a homeodomain associated with a leucine zipper. The expression of this transcriptional factor is induced in leaves and roots of coffee plants subjected to various water scarcity conditions (both moderate and severe); transgenic plants that over-express this gene exhibit greater tolerance both to different drought intensities and to high salt concentrations.
C12N 15/29 - Gènes codant pour des protéines végétales, p. ex. thaumatine
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
43.
FUNCTIONALIZED ARYL AND/OR HETEROARYL UREA COMPOUNDS; A METHOD FOR SYNTHESIZING SAME; A PHARMACEUTICAL COMPOSITION CONTAINING SUCH COMPOUNDS AND USES THEREOF
The present invention relates to functionalized aryl and/or heteroaryl urea compounds of general formula (I) and (II), and also salts and/or solvates and polymorphs thereof which can inhibit protein kinases from the MAPK family and also modulate cytokines such as TNF and IL1β. Furthermore, the present invention relates to a method for synthesizing such compounds, a method for preparing a pharmaceutical composition which will be used in the production of medicines for treating or preventing disorders associated with acute or chronic pain, and also for treating inflammatory diseases, said inflammation being acute or chronic.
C07D 233/64 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux hydrocarbonés substitués, liés aux atomes de carbone du cycle, p. ex. histidine
C07C 275/26 - Dérivés d'urée, c.-à-d. composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso ayant des atomes d'azote de groupes urée liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons
A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p. ex. éthers en couronne, guanadrel
A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
A61K 31/17 - Amides, p. ex. acides hydroxamiques ayant le groupe N-C(O)-N ou N-C(S)-N, p. ex. urée, thiourée, carmustine
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
METHOD FOR LABELLING WITH RADIONUCLIDES MURINE OR HUMAN, MONOCLONAL OR POLYCLONAL ANTI-TUMOUR NECROSIS FACTOR ANTIBODIES ASSOCIATED WITH DISEASES WITH PHYSIOPATHOGENESIS INVOLVING TUMOR NECROSIS FACTOR; REAGENT FOR IN VIVO AND/OR IN VITRO DIAGNOSIS ON THE BASIS OF MURINE OR HUMAN, MONOCLONAL OR POLYCLONAL ANTI-TUMOR NECROSIS FACTOR ANTIBODIES LINKED TO RADIONUCLIDES; METHODS FOR DIAGNOSING IN VITRO AND/OR IN VIVO DISEASES WITH PHYSIOPATHOGENESIS INVOLVING THE TUMOUR NECROSIS FACTOR, USING THE THUS OBTAINED REAGENT, AND KIT CONTAINING SAID REAGENT FOR DIAGNOSING DISEASES WITH PHYSIOPATHOGENESIS INVOLVING THE TUMOUR NECROSIS FACTOR
The present invention relates to a method for labelling with radionuclides murine or human, monoclonal or polyclonal anti-tumour necrosis factor antibodies, to a reagent for in vivo and/or in vitro diagnosis on the basis of murine or human, monoclonal or polyclonal anti-tumor necrosis factor antibodies labelled with radionuclides, and to the diagnostic use thereof; to the method for diagnosing in vitro and/or in vivo diseases with physiopathogenesis involving the tumour necrosis factor, and to the kit for diagnosing diseases with physiopathogenesis involving the tumour necrosis factor, using the said reagent.
Diabetes mellitus is a disease which, according to the World Health Organisation, is responsible for a significant proportion of deaths throughout the world. In spite of the large number of glycemic control products aimed at diabetes, there still exist pharmacological and pharmacokinetic gaps to be filled. The present invention aims at describing a method for developing a polymer system for encapsulating amylin and agonist analogues in the form of nanoparticles and microparticles. Another object of the invention is a method of functional in vitro evaluation of amylin released from polymer encapsulation systems. The invention further describes the use of the system for producing a medicament for amylin replenishment therapy in patients, which can be used for treating or preventing metabolic diseases.
A61K 9/66 - Préparations en capsules, p. ex. de gélatine, de chocolat du type à libération prolongée ou discontinue contenant des émulsions, dispersions ou solutions
A61K 9/62 - Revêtements organiques contenant des hydrates de carbone ou leurs dérivés
A61K 9/60 - Revêtements organiques contenant des gommes ou des résines naturelles
A61K 9/58 - Revêtements organiques contenant des polymères synthétiques solides
A61K 9/52 - Préparations en capsules, p. ex. de gélatine, de chocolat du type à libération prolongée ou discontinue
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
A61P 5/48 - Médicaments pour le traitement des troubles du système endocrinien des hormones pancréatiques
46.
SYNTHETIC RNA MOLECULE OF THE HEPATITIS C VIRUS, PRODUCTION METHOD OF SAME AND USE THEREOF AS AN INTERNAL CONTROL FOR THE QUANTIFICATION AND/OR IDENTIFICATION OF THE HEPATITIS C VIRUS
The present invention relates to an internal control for the detection and/or quantification of the hepatitis C virus using various methods. Said control may have one or two nucleotide sequence modifications: an insertion and/or substitution of one sequence for another, making the molecule polyvalent, and allowing it to be used in various quantification methods. The present invention relates to the method for developing said internal control. The present invention also relates to a detection and/or quantification kit for hepatitis C virus.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
The present invention relates to a method for producing polyethylene terephthalate (PET)-based resins, that are modified by the incorporation of co-monomers which can be produced by sustainable chemical routes, such as glycerol and derivatives thereof, as an alternative to ethylene glycol as a source of hydroxyl in the reaction. An additional objective is the development of sustainable alternatives for the production of PET-derived materials with higher molar mass, intrinsic viscosity and transparency (decrease in crystallinity), as is required by the film and packaging industry. The invention also relates to the use of the PET-derived materials that are modified by the incorporation of co-monomers which can be produced by sustainable chemical routes and to the PET-derived materials (resins) that are modified by the incorporation of co-monomers which can be produced by sustainable chemical routes.
The present invention pertains to the field of chemical engineering, and its main subject matter is a method for producing ethanol from residual biomass from the cellulose industry. The biomass is processed in a single reaction vessel in which enzymatic hydrolysis and fermentation (saccharification) occur simultaneously in an advantageous manner. The invention also relates to the ethanol produced by the method described.
C12P 7/10 - Éthanol en tant que produit chimique et non en tant que boisson alcoolique préparé comme sous-produit, ou préparé à partir d'un substrat constitué par des déchets ou par des matières cellulosiques d'un substrat constitué par des matières cellulosiques
C12P 7/14 - Fermentation en plusieurs étapesFermentation avec différents types de micro-organismes ou avec réemploi de micro-organismes
49.
PROCESS AND COMPOSITION FOR TREATMENT OF CANINE AND HUMAN LEISHMANIASIS
Process and immune chemotherapeutic/pharmaceutical composition for treatment of canine and human Leishmaniasis comprising a vaccine containing the FML antigen (Fucose Mannose-Ligand) and saponin adjuvant, used in association with chemotherapeutic agents, showing healing property, leaving the dogs previously infected, in the condition of sterile cure of visceral and tegumentary leishmaniasis, characterized by absence of parasites and the overall absence of Leishmania DNA, aiming to stave off the spread of the parasite which causes canine visceral leishmaniasis in dog to the insect transmitter, thus to other dogs and humans. The invention also comprises also the use of the aforementioned composition to produce formulations designed to treat canine visceral leishmaniasis and visceral and murine tegumentary leishmaniasis, human and canine, as well as a kit comprising immune chemotherapeutic agents to treat the same diseases.
The present invention relates to a plant growth promoting protein complex. More specifically, the invention relates to the use of specific proteins from the Anaphase Promoting Complex/Cyclosome for increasing shoot growth rates and/or enhancing cell division rates.
C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
51.
NEW COMPOUNDS OF THE PTEROCARPANQUINONE FAMILY, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION CONTAINING THE NEW COMPOUNDS OF THE PTEROCARPANQUINONE FAMILY, USES AND THERAPEUTIC METHOD
The invention belongs to the chemical pharmaceutical field, and the new compounds of the pterocarpanquinone family having formula (I) according to the invention can be reduction activated, generating alkylating species in the intracellular medium, and exhibit a selective cytotoxic effect, in particular for constantly dividing animal cells of human and/or non-human mammals; they are therefore useful for the treatment of diseases and/or disorders related to the phenomenon of undesirable cell proliferation. These compounds are also effective for the treatment of diseases and/or disorders related to a rise in THF-α in human and non-human mammals and to the method for producing these compounds, to pharmaceutical compositions containing said compounds of formula (I), to the use of said compounds of formula (I), to a medicament containing said compounds and to treatment methods.
The present invention relates to N-acyl hydrazine compounds capable of promoting vascular smooth muscle relaxation by activation of the biosynthesis of nitric oxide (NO) and having the general formula (I), and to the method for producing same, to pharmaceutical compositions containing same, to uses thereof and methods for treatment of dysfunctions related to NO synthesis in human and non-human mammals, and to the treatment of muscle disorders.
C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61K 31/381 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des cycles à cinq chaînons
A61P 9/04 - Agents inotropes, c.-à-d. stimulants de la contraction cardiaqueMédicaments pour le traitement de l'insuffisance cardiaque
A61P 9/08 - Vasodilatateurs pour des indications multiples
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
The present invention refers to a catalytic process of hydrogenation/hydrogenolysis of glycerol or glycerine into oxygenated compounds and hydrocarbons containing 1 to 3 carbon atoms, using supported metal catalysts based on metals from group VIII-B of the periodic table of the elements, which have been supported by standard techniques on materials having a high specific area, such as powder charcoal, aluminum silicate, alumina, clays, zeolites and molecular sieves.
C07C 29/60 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par élimination de groupes hydroxyle, p. ex. par déshydratation
54.
PREPARATION OF HETEROGENEOUS CATALYSTS USED IN SELECTIVE HYDROGENATION OF GLYCERIN TO PROPENE, AND A PROCESS FOR THE SELECTIVE HYDROGENATION OF GLYCERIN TO PROPENE
The present invention relates to a process of formulating and preparing supported multi-metal catalysts based on metal oxides and inorganic salts of metals. The impregnation technique is employed by two methods: the slurry method and the modified-pH variation method, which are used in two steps for obtaining the catalyst. The present invention also relates to a process called Glycerol to Propene (GTP) process, corresponding to the transformation of glycerol or glycerin to propene. The reaction involved in the process of the present invention is the selective hydrogenation of glycerin, which takes place by contact of the charge of glycerin carried by hydrogen in a continuous stream system on the catalytic bed containing multi-metal catalysts, specifically prepared for this purpose.
The present invention refers to the construction of cloning vectors containing the max gene. Especially, the present invention refers to the introduction of cloning vectors containing the max gene in cells using transport vectors. In addition, the presence of cloning vectors containing the max gene in cells allows the differential expression of the max gene in the same cells. In addition, the present invention refers to a method of gene therapy in which the differential expression of the max gene has cytoprotective activity, especially neuroprotective activity, and is capable of application to medical and veterinary therapeutics of neurodegenerative conditions.
The present patent application refers to a process of producing alcohol from the fermentation of hydrolyzed sugars of gelling and/or thickening polysaccharides obtained from algae cultivated in natural or artificial aquatic environments, eutrophized or not eutrophized. The main steps of this process are: collection and cleaning of algae; fragmentation; drying; hydrolysis of the total sugars produced by the algae; fermentation of the sugars resulting from hydrolysis of the algae polysaccharides, with the use of yeast capable of promoting fermentation of galactosides; and alcohol distillation.
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (USA)
UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (Brésil)
Inventeur(s)
Pasqualini, Renata
Arap, Wadih
Giordano, Ricardo
Cardo-Vila, Marina
Valente, Ana, Paula
Ceneviva Lacerda De Almeida, Fabio
Abrégé
The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particularly D(LPR), that selectively target VEGFR-1 and NRP-1 expressing cells. Targeted molecules in accordance with the invention are useful in the treatment and detection of neovascular or angiogenic VEGF associated disorders, including but not limited to cancer, obesity, diabetes, asthma, arthritis, cirrhosis and ocular diseases.
The present invention is related to the endostatine preparation for the treatment of cancer due to its capacity to recede the formation of blood vessels of a pre- established tumor. More specifically, the present invention is related to the preparation of the endostatine naturally dimerized or oligomeric, formed by the association non covalent among the protein subunities, presented in the soluble form and being of easy clinical application.
The present invention refers to a process of transesterification of mono-, di and triglycerides present in vegetable oils and animal fats, which are transesterified with alcohols of 1 to 3 carbon atoms making use of basic solid heterogeneous catalyzers, being the products of the reaction used as fuel or additive for fuel, as solvents, as intermediaries of tensoactives or as detergents .
C11C 3/10 - Graisses, huiles ou acides gras obtenus par transformation chimique des graisses, huiles ou acides gras, p. ex. ozonolyse par estérification des graisses ou des huiles par interestérification
60.
COMPOSITION COMPRISING FRACTIONS OR SUB-FRACTIONS OF LEISHMANIA PROMASTIGOTES OR LEISHMANIA AMASTIGOTES CALLED FUCOSE MANNOSE LIGAND (FML) AND SAPONIN, COMPOSITION FOR PREPARATION OF LEISHMANIASIS TRANSMISSION BLOCKING VACCINES IN HUMANS AND ANIMALS COMPRISING FRACTIONS OR SUB-FRACTIONS OF LEISHMANIA PROMASTIGOTES OR LEIS
The invention relates to a composition comprising Leishmania promastigotes or Leishmania amastigotes fractions or sub-fractions called 'Fucose Mannose Ligand' (FML) and saponin. The invention also comprises the use of the composition for preparation of a blocking vaccine impeding Leishmaniasis transmission in humans or animals.
C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C07K 4/12 - Peptides ayant jusqu'à 20 amino-acides dans une séquence indéterminée ou partiellement déterminéeLeurs dérivés provenant d'animauxPeptides ayant jusqu'à 20 amino-acides dans une séquence indéterminée ou partiellement déterminéeLeurs dérivés provenant d'humains