Universita degli Studi di Roma "La Sapienza"

Italie

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Type PI
        Brevet 211
        Marque 2
Juridiction
        International 165
        États-Unis 38
        Canada 8
        Europe 2
Date
Nouveautés (dernières 4 semaines) 2
2024 décembre 5
2024 novembre 1
2024 octobre 1
2024 septembre 3
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Classe IPC
A61P 35/00 - Agents anticancéreux 17
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier 10
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur  9
A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie 7
A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains 6
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Classe NICE
41 - Éducation, divertissements, activités sportives et culturelles 2
42 - Services scientifiques, technologiques et industriels, recherche et conception 2
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture. 2
09 - Appareils et instruments scientifiques et électriques 1
14 - Métaux précieux et leurs alliages; bijouterie; horlogerie 1
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Statut
En Instance 23
Enregistré / En vigueur 190
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1.

PROCESS AND KIT FOR THE IN VITRO DIAGNOSIS OF THE ANTIPHOSPHOLIPID ANTIBODY SYNDROME

      
Numéro d'application 18262783
Statut En instance
Date de dépôt 2022-01-27
Date de la première publication 2024-12-26
Propriétaire Università degli Studi di Roma "La Sapienza" (Italie)
Inventeur(s)
  • Sorice, Maurizio
  • Misasi, Roberta
  • Garofalo, Tina
  • Longo, Agostina
  • Capozzi, Antonella
  • Manganelli, Valeria
  • Recalchi, Serena
  • Riitano, Gloria

Abrégé

The present invention relates to a process to perform an in vitro diagnosis of the antiphospholipid antibody syndrome. carried out on isolated samples of the subject to be diagnosed. Furthermore, the present invention relates to a kit which allows to perform a non-invasive diagnosis of the antiphospholipid antibody syndrome from an isolated sample of the subject for whom such a diagnosis has to be made.

Classes IPC  ?

  • G01N 33/564 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes

2.

LIPID CONVERSION PROCESS FOR OBTAINING BIODIESEL

      
Numéro d'application IB2024055743
Numéro de publication 2024/261596
Statut Délivré - en vigueur
Date de dépôt 2024-06-12
Date de publication 2024-12-26
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
  • Cairone, Francesco
  • Fabrizi, Giancarlo
  • Goggiamani, Antonella
  • Iazzetti, Antonia

Abrégé

The present invention generally relates to a conversion process of lipids or oils to obtain lower alcohol esters to be used in the production of automotive biodiesel. In particular, the invention relates to the conversion of organic acids and triglycerides of plant origin into corresponding esters of C1-C4 lower alcohols, preferably methyl alcohol. More specifically, the invention relates to a method for producing biodiesel starting from vegetable oils, such as corn oil deriving from post-fermentation. The process of the invention is quantitative in transforming both fatty acids and glycerides into the corresponding esters thanks to the presence of two immiscible phases: an organic phase, consisting of fatty acid methyl esters (FAME) and an aqueous phase consisting of water, glycerol and acid catalyst. The lower alcohol esters, in particular the methyl esters thus produced, can be used in automotive fuel blends.

Classes IPC  ?

  • C11C 3/00 - Graisses, huiles ou acides gras obtenus par transformation chimique des graisses, huiles ou acides gras, p.ex. ozonolyse
  • C07C 67/00 - Préparation d'esters d'acides carboxyliques
  • C07C 67/02 - Préparation d'esters d'acides carboxyliques par interréaction des groupes ester, c. à d. par transestérification
  • C11C 3/10 - Graisses, huiles ou acides gras obtenus par transformation chimique des graisses, huiles ou acides gras, p.ex. ozonolyse par estérification des graisses ou des huiles par interestérification

3.

QUANTUM BERNOULLI FACTORY PHOTONIC CIRCUIT INDEPENDENT OF INPUT STATE BIAS

      
Numéro d'application EP2024065333
Numéro de publication 2024/256220
Statut Délivré - en vigueur
Date de dépôt 2024-06-04
Date de publication 2024-12-19
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATORY (Portugal)
  • CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
Inventeur(s)
  • Fagundes Galvão, Ernesto
  • Sciarrino, Fabio
  • Carvacho Vera, Gonzalo Alfredo
  • Hoch, Francesco
  • Spagnolo, Nicolò
  • Osellame, Roberto
  • Giordani, Taira
  • Castello, Luca

Abrégé

The present invention concerns a scheme that allows to create a Quantum-to-Quantum Bernoulli Factory, wherein random bits and qubits can be generated given input qubits, using a quantum photonic system that can take advantage of the different information coding approaches using states of single photons According to the invention, inversion, multiplication and sum operations can be realized with photon qubits and can be concatenated without generating noise.

Classes IPC  ?

  • G06F 7/544 - Méthodes ou dispositions pour effectuer des calculs en utilisant exclusivement une représentation numérique codée, p.ex. en utilisant une représentation binaire, ternaire, décimale utilisant des dispositifs non spécifiés pour l'évaluation de fonctions par calcul
  • G06E 3/00 - Dispositifs non prévus dans le groupe , p.ex. pour traiter des données analogiques hybrides
  • G06N 10/00 - Informatique quantique, c. à d. traitement de l’information fondé sur des phénomènes de mécanique quantique

4.

Method and Relative System for the Detection of a Viral Agent by Microwave Dielectric Spectroscopy

      
Numéro d'application 18723664
Statut En instance
Date de dépôt 2022-12-01
Date de la première publication 2024-12-12
Propriétaire
  • ISTITUTO NAZIONALE DI ASTROFISICA (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SPIENZA" (Italie)
  • ISTITUTO SUPERIORE DI SANITÀ (Italie)
  • CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
Inventeur(s)
  • Bolli, Pietro
  • Brucalassi, Anna
  • Chiarucci, Simone
  • Cresci, Luca
  • Del Vecchio, Ciro
  • Di Ninni, Paola
  • Nesti, Renzo
  • Panella, Dario
  • Tozzi, Andrea
  • Apollonio, Francesca
  • Liberti, Micaela
  • Argentini, Claudio
  • Amendola, Antonello
  • Fiorentini, Cristiano
  • Fortuna, Claudia
  • Marsili, Giulia
  • Venturi, Giulietta
  • Barucci, Marco

Abrégé

A method for detecting a viral agent including the steps of placing a first sample that includes an isotonic solution in a waveguide which is axially delimited by a pair of containment elements that are substantially transparent to microwaves and define respective interfaces of the sample; transmitting a signal with frequency variable in a predetermined microwave band to the first sample; acquiring at least one dielectric parameter of the first sample as the frequency varies by means of transmission and reflection measurements; repeating the previous steps for a second sample; and performing a differential spectroscopic analysis on the parameters for assessing the presence of a viral agent in at least one of the samples.

Classes IPC  ?

  • G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c. à d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
  • G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide

5.

MULTIDIRECTIONAL HYSTERETIC DAMPER ENDOWED WITH NEGATIVE STIFFNESS

      
Numéro d'application 18697157
Statut En instance
Date de dépôt 2022-09-30
Date de la première publication 2024-12-05
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Salvatore, Andrea
  • Carboni, Biagio
  • Lacarbonara, Walter

Abrégé

Provided is a mechanical device to be connected in series or in parallel to a structure to be protected from dynamic stresses so as to vary mechanical features of the system and control the general dynamic behavior. The mechanical device is a multi-purpose rheological element employable in various applications including vibration isolation, vibration absorption, shock absorption, energy dissipation, and other applications based on rheological force-movement behavior.

Classes IPC  ?

  • E04H 9/02 - Bâtiments, groupes de bâtiments ou abris conçus pour résister à des situations extérieures anormales, p.ex. à des bombardements, à des séismes ou à des climats extrêmes, ou pour se protéger de ces situations résistant aux séismes ou à l'effondrement du sol
  • F16F 15/04 - Suppression des vibrations dans les systèmes non rotatifs, p.ex. dans des systèmes alternatifs; Suppression des vibrations dans les systèmes rotatifs par l'utilisation d'organes ne se déplaçant pas avec le système rotatif utilisant des moyens élastiques

6.

USE OF MICRORNAS AS TOOLS FOR THE DIAGNOSIS AND DIFFERENTIATION OF TAUOPATHIES

      
Numéro d'application IT2024050079
Numéro de publication 2024/228220
Statut Délivré - en vigueur
Date de dépôt 2024-04-24
Date de publication 2024-11-07
Propriétaire
  • UNIVERSITA' DI TRENTO (Italie)
  • ISTITUTO SUPERIORE DI SANITA' (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Denti, Michela Alessandra
  • Ricci, Leonardo
  • Grasso, Margherita
  • Zeni, Andrea
  • Piscopo, Paola
  • Rivabene, Roberto
  • Bruno, Giuseppe

Abrégé

The present invention relates to microRNAs for use in diagnostic methods for diagnosing and/or for distinguishing by diagnosis Alzheimer's disease (AD), Frontotemporal Dementia (FTD), and possibly other tauopathies, and/or for measuring therapeutic effect of a treatment of FTD or AD.

Classes IPC  ?

  • C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
  • A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
  • A61K 31/7105 - Acides ribonucléiques naturels, c. à d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester 

7.

GFRAL RECEPTOR INHIBITOR FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

      
Numéro d'application IB2024052885
Numéro de publication 2024/201293
Statut Délivré - en vigueur
Date de dépôt 2024-03-26
Date de publication 2024-10-03
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Garofalo, Stefano
  • Limatola, Cristina
  • Cocozza, Germana

Abrégé

The invention relates to a GFRAL receptor inhibitor for use in the treatment of amyotrophic lateral sclerosis, in particular for the treatment of cachexia and/or for reducing weight loss in a subject suffering from amyotrophic lateral sclerosis. In particular, said inhibitor is a short hairpin RNA (shRNA). Pharmaceutical compositions and vectors comprising said inhibitor for the described uses also fall within the scope of the invention.

Classes IPC  ?

  • C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
  • A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques 
  • A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux

8.

SELECTIVE DELIVERY OF ONCO-SUPPRESSIVE MIRNA (MIR126) TO METASTATIC MELANOMA CELLS RESISTANT TO THERAPIES

      
Numéro d'application IB2024052487
Numéro de publication 2024/189572
Statut Délivré - en vigueur
Date de dépôt 2024-03-14
Date de publication 2024-09-19
Propriétaire
  • ISTITUTO SUPERIORE DI SANITA' (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Felli, Nadia
  • Felicetti, Federica
  • Biffoni, Mauro
  • Flego, Michela
  • Arasi, Maria Beatrice
  • Palocci, Cleofe

Abrégé

The present invention discloses carriers with an onco-suppressive agent and selectively directed to a tumoral target for the treatment of metastatic melanoma resistant to a target therapy.

Classes IPC  ?

  • C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
  • A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques 
  • A61K 38/00 - Préparations médicinales contenant des peptides
  • A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
  • A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif
  • A61P 31/00 - Agents anti-infectieux, c. à d. antibiotiques, antiseptiques, chimiothérapeutiques
  • B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p.ex. génie protéique ou administration de médicaments

9.

USE OF MOLECULES ISOLATED FROM BACTERIA PRESENT IN DIGESTATE PRODUCED BY BIOGAS PLANTS AS IMMUNOSTIMULANTS OF PLANT DEFENCE RESPONSES

      
Numéro d'application EP2024056272
Numéro de publication 2024/188899
Statut Délivré - en vigueur
Date de dépôt 2024-03-08
Date de publication 2024-09-19
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
  • AGROLIO SRL (Italie)
Inventeur(s)
  • Lionetti, Vincenzo
  • Agresti, Savino
  • De Lorenzo, Giulia
  • Greco, Marco

Abrégé

A process is described for the valorisation of the microbial fraction contained in the waste material from biogas plants following anaerobic digestion of olive pomace, thanks to which an extract enriched in proteins and peptides of microbial origin is obtained for use as a plant protection product in agricultural production.

Classes IPC  ?

  • A01N 25/34 - Formes façonnées, p.ex. feuilles, non prévues dans l'un quelconque des autres sous-groupes du présent groupe principal
  • A01N 37/02 - Acides carboxyliques saturés ou leurs thio-analogues; Leurs dérivés
  • A01N 37/06 - Acides carboxyliques non saturés ou leurs thio-analogues; Leurs dérivés
  • A01N 37/44 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un contenant au moins un groupe carboxylique ou un thio-analogue, ou un de leurs dérivés, et un atome d'azote lié au même squelette carboné par une liaison simple ou double, cet atome d'azote ne faisant pas partie d'un dérivé ou d'un thio-analogue d'un
  • A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle  avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
  • A01N 63/20 - Bactéries; Substances produites par des bactéries ou obtenues à partir de celles-ci
  • A01N 65/22 - Lamiaceae ou Labiatae [famille de la menthe], p.ex. thym, romarin, scutellaire, brunelle, lavande, perilla, menthe pouliot, menthe poivrée ou menthe verte
  • A01P 21/00 - Régulateurs de croissance des végétaux
  • C05F 3/00 - Engrais fabriqués à partir des excréments humains ou animaux, y compris le fumier
  • C05F 5/00 - Engrais fabriqués à partir de déchets de distillerie ou de sucreries, de mélasses, vinasses ou de déchets ou résidus similaires
  • C05F 7/00 - Engrais fabriqués à partir des eaux résiduaires ou d'épandage, wagage, limon ou masses similaires
  • C05F 9/00 - Engrais fabriqués à partir des ordures ménagères ou de ville
  • C05F 11/00 - Autres engrais organiques
  • A01N 25/02 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'application; Substances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles contenant des liquides comme supports, diluants ou solvants

10.

WEARABLE AND FLEXIBLE ELECTROCHEMICAL SWEAT SENSOR CONSISTING OF A POLYMER COMPOSITE MEMBRANE CONTAINING GRAPHENE

      
Numéro d'application 18578541
Statut En instance
Date de dépôt 2022-07-15
Date de la première publication 2024-09-05
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Sarto, Maria Sabrina
  • Bidsorkhi, Hossein Cheraghi
  • D'Aloia, Alessandro Giuseppe
  • Tamburrano, Alessio
  • Ballam, Lavanya Rani

Abrégé

A multi-composite electrochemical cell substantially consists of a thin polymer membrane including three different adjacent sectors, which are made of the same appropriately seamlessly modified polymer, incorporating in the polymer one or more conductive phases, or conductive fillers, such as graphene, metal, or a combination thereof. In the first sector the polymer material incorporates graphene nanoplatelets and acts as a cathode; in the second sector, interposed between the other two, the polymer material acts as an insulating spacer; in the third sector the polymer material incorporates graphene nanoplatelets and a metal filler or immersed metal contact rheophore, with negative standard reduction potential, and acts as an anode; wherein the metal filler is in the form of dispersed powder or dispersed flakes, or of a thin sheet incorporated in the polymer.

Classes IPC  ?

  • A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang
  • A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
  • A61B 5/1468 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p.ex. par des moyens polarographiques
  • C01B 32/225 - Expansion; Exfoliation

11.

ORTHODONTIC DEVICE FOR CORRECTING THE POSITION OF TEETH

      
Numéro d'application IB2024051368
Numéro de publication 2024/171070
Statut Délivré - en vigueur
Date de dépôt 2024-02-14
Date de publication 2024-08-22
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Galluccio, Gabriella
  • De Stefano, Adriana Assunta
  • Ierardo, Gaetano
  • Guerra, Claudio
  • Corridore, Denise
  • Guarnieri, Rosanna

Abrégé

Orthodontic device (100) comprising a body (3), a constraining surface (30) for the constraint to a tooth, preferably to a molar tooth, a first housing (6), a second housing (7), a first closing element (1) for the first housing (6), a second closing element (2) for the second housing (7); said first closing element (1) and second closing element (2) being able to be moved independently of each other so as to define a first open condition and a first closed condition of the first housing (6) and a second open condition and a second closed condition of the second housing (7), wherein said first condition of the first housing (6) is independent of said second condition of the second housing (7) and vice versa.

Classes IPC  ?

  • A61C 7/14 - Brackets; Fixation des brackets aux dents
  • A61C 7/28 - Fixation de l'arc vestibulaire ou du fil d'arcade au bracket

12.

MEASUREMENT SYSTEM AND METHOD OF ELECTRIC PERMITTIVITY AT 0 HZ

      
Numéro d'application 18565954
Statut En instance
Date de dépôt 2022-06-01
Date de la première publication 2024-08-15
Propriétaire Università degli Studi di Roma "La Sapienza" (Italie)
Inventeur(s) De Bellis, Giovanni

Abrégé

A measurement method (100) of the electric permittivity (ε) at 0 Hz of a substance (1), irrespective of the aggregation state, comprising the steps of: pre-arranging (101) a rheometer (2) comprising an electrorheology module (20), provided with a fixed first plate (21) and said movable second plate (22); connecting (102) a voltage generator (3) to said rheometer (2); placing (103) the substance (1) between said first plate (21) and said second plate (22); arranging (104) said second plate (22) at a distance (D) from said first plate (21); imposing (105) said potential difference (ΔV) at 0 Hz between said first plate (21) and said second plate (22); measuring (106) a normal force (F) to which said second plate (22) is subjected; converting (108) the normal force (F) to obtain the dielectric permittivity (ε) of the substance (1).

Classes IPC  ?

  • G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
  • G01N 11/14 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement en déplaçant un corps à l'intérieur du matériau en utilisant des corps en rotation, p.ex. moulinet

13.

BIOELECTROCHEMICAL METHOD FOR THE REMEDIATION OF WATER CONTAMINATED WITH CHLORINATED ALIPHATIC HYDROCARBONS

      
Numéro d'application IB2024050621
Numéro de publication 2024/157166
Statut Délivré - en vigueur
Date de dépôt 2024-01-23
Date de publication 2024-08-02
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Zeppilli, Marco
  • Dell'Armi, Edoardo
  • Majone, Mauro
  • Petrangeli Papini, Marco

Abrégé

An electrochemical method is described which stimulates microbial reactions for the removal of chlorinated aliphatic hydrocarbons from water contaminated with chlorinated aliphatic hydrocarbons, which finds use in the field of remediation of groundwater contaminated with chlorinated solvents.

Classes IPC  ?

  • C02F 1/461 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse
  • C02F 3/00 - Traitement biologique de l'eau, des eaux résiduaires ou des eaux d'égout
  • C02F 3/34 - Traitement biologique de l'eau, des eaux résiduaires ou des eaux d'égout caractérisé par les micro-organismes utilisés
  • C02F 101/36 - Composés organiques contenant des atomes d'halogène

14.

MECHATRONIC CONTROL DEVICE

      
Numéro d'application 18289549
Statut En instance
Date de dépôt 2022-05-09
Date de la première publication 2024-07-25
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s) Martirano, Luigi

Abrégé

An electronic electrical device, comprising a first electrical conductor for the input of electric current; a second electrical conductor for the output of electric current; a first electrical control device adapted to have two positions to electrically connect and disconnect the first electrical conductor and the second electrical conductor to/from each other; a second electrical control device adapted to have two positions to electrically connect and disconnect the first electrical conductor and the second electrical conductor to/from each other; first actuation means comprising a digital electronic controller; second actuation means comprising only mechanical and/or electromechanical components; wherein the first actuation means are adapted to vary the position of said first electrical control device independently of said second actuation means; and wherein the second actuation means are adapted to vary the position of said second electrical control device independently of said first actuation means.

Classes IPC  ?

  • H01H 9/00 - INTERRUPTEURS ÉLECTRIQUES; RELAIS; SÉLECTEURS; DISPOSITIFS DE PROTECTION - Détails de dispositifs de commutation non couverts par

15.

COMPOSITIONS FOR USE IN THE PREVENTION AND/ OR TREATMENT OF INTELLECTUAL DISABILITY AND NEURODEGENERATIVE DISEASES IN A SUBJECT WITH DOWN SYNDROME

      
Numéro d'application 18560142
Statut En instance
Date de dépôt 2022-04-08
Date de la première publication 2024-07-18
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Barone, Eugenio
  • Tramutola, Antonella
  • Perluigi, Marzia

Abrégé

Composition for use in the prevention and/or in the treatment of intellectual disability and neurodegenerative diseases in a subject with Down syndrome, wherein the composition comprises as an active agent at least one compound belonging to the class of dipeptidy 1-peptidase IV (DPP4) enzyme inhibitors and also to the class of gliptins.

Classes IPC  ?

  • A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
  • A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

16.

ABUTMENT FOR DENTAL IMPLANT

      
Numéro d'application IB2024050274
Numéro de publication 2024/150162
Statut Délivré - en vigueur
Date de dépôt 2024-01-11
Date de publication 2024-07-18
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Guerra, Fabrizio
  • Ottolenghi, Livia
  • Di Giorgio, Roberto
  • Galluccio, Gabriella
  • Cicconetti, Andrea
  • Vozza, Iole
  • Nardi, Gianna Maria
  • Corridore, Denise
  • Mazur, Marta
  • Sansotta, Marco
  • Grassi, Roberta
  • Sansotta, Laura

Abrégé

An implant abutment, with the purpose of preserving the volume and trophism of the cortical bone and of the gingival tissue, comprises : an inserting portion; a contact portion touching the gingiva, integral with said inserting portion; a projecting portion with substantially circular shape projecting with respect to said contact portion to protect the gingival mucosa, integral with the contact portion through a concave profile; and a coronal portion integral with said projecting portion, whereon the prosthetic crown is installed, wherein the inserting portion, the contact portion, the projecting portion and the coronal portion are formed by one single piece which defines the abutment.

Classes IPC  ?

  • A61C 8/00 - Moyens destinés à être fixés à l'os de la mâchoire pour consolider les dents naturelles ou pour y assujettir des prothèses dentaires; Implants dentaires; Outils pour l'implantation
  • A61C 13/00 - Prothèses dentaires; Leurs procédés de fabrication

17.

REMOVABLE, WATERPROOF MULTI-LAYER COATING HAVING ANTIBACTERIAL PROPERTIES FOR CONTACT SURFACES AND METHOD FOR THE PREPARATION THEREOF

      
Numéro d'application 18261969
Statut En instance
Date de dépôt 2022-01-19
Date de la première publication 2024-03-14
Propriétaire UNIVERSITA’ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
  • Sarto, Maria Sabrina
  • Uccelletti, Daniela
  • Polimeni, Antonella
  • De Bellis, Giovanni
  • Bossu', Maurizio
  • Bidsorkhi, Hossein Cheraghi
  • Bruni, Erika
  • Bellagamba, Irene
  • Ballam, Lavanya Rani

Abrégé

A multi-layer coating with antibacterial and anti-COVID properties which is usable in various environments, including hospitals, and which can be easily deposited by spraying on different surfaces and capable of providing an effective removable barrier against pathogens and bacteria, which waterproof coating is characterized in that it uses graphene nanoparticles as an antibacterial and anti-COVID agent deposited by spraying a polymer material as a host layer on the surface to promote the dispersion and uniform surface distribution thereof, the polymer material being directly adhered by spraying to the surface to be coated or sprayed on a second polymer, in turn sprayed on the surface to be coated, which is used as an element to promote the adhesion of the first polymer forming the antibacterial and anti-COVID coating to the surface to be coated.

Classes IPC  ?

  • A01N 59/16 - Métaux lourds; Leurs composés
  • A01N 25/10 - Composés macromoléculaires
  • A01N 59/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des éléments ou des composés inorganiques
  • A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges
  • C09D 1/00 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, à base de substances inorganiques
  • C09D 5/00 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, caractérisées par leur nature physique ou par les effets produits; Apprêts en pâte
  • C09D 5/02 - Peintures émulsions
  • C09D 5/14 - Peintures contenant des biocides, p.ex. fongicides, insecticides ou pesticides
  • C09D 7/20 - Diluants ou solvants
  • C09D 7/62 - Adjuvants non macromoléculaires inorganiques modifiés par traitement avec d’autres composés
  • C09D 139/06 - Homopolymères ou copolymères de N-vinylpyrrolidones
  • C09D 167/04 - Polyesters dérivés des acides hydroxycarboxyliques, p.ex. lactones

18.

MULTICOMPONENT LIPID NANOPARTICLES WITH HIGH CELLULAR FUSOGENICITY FOR THE DELIVERY OF NUCLEIC ACIDS AND RELATED PREPARATION PROCESS

      
Numéro d'application IB2023057827
Numéro de publication 2024/028785
Statut Délivré - en vigueur
Date de dépôt 2023-08-02
Date de publication 2024-02-08
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA - LA SAPIENZA (Italie)
  • UNICAM - UNIVERSITÀ DEGLI STUDI DI CAMERINO (Italie)
  • SCUOLA NORMALE SUPERIORE (Italie)
Inventeur(s)
  • Caracciolo, Giulio
  • Pozzi, Daniela
  • Quagliarini, Erica
  • Renzi, Serena
  • Digiacomo, Luca
  • Amici, Augusto
  • Marchini, Cristina
  • Cui, Lishan
  • Wang, Junbiao
  • Cardarelli, Francesco

Abrégé

The present invention relates to the process of preparing multicomponent lipidic nanoparticles (LNP) with high cellular fusogenicity for the delivery of nucleic acids and in particular for DNA vaccination. The invention also relates to the nanoparticles thus obtained. In particular, the lipidic nanoparticles of the invention are obtained by combining cationic lipids and ionizable lipids in a specific ratio to each other to be administered both subcutaneously (intradermally or intramuscularly) and systemically with fewer side effects than the lipidic nanoparticles known in the art.

Classes IPC  ?

  • A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
  • A61K 9/51 - Nanocapsules
  • C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
  • C12N 15/00 - Techniques de mutation ou génie génétique; ADN ou ARN concernant le génie génétique, vecteurs, p.ex. plasmides, ou leur isolement, leur préparation ou leur purification; Utilisation d'hôtes pour ceux-ci

19.

NEURAL ELECTRODE MADE WITH SOFT POLYMERS AND RAPID PROTOTYPING TECHNIQUES

      
Numéro d'application IB2023056964
Numéro de publication 2024/009237
Statut Délivré - en vigueur
Date de dépôt 2023-07-05
Date de publication 2024-01-11
Propriétaire
  • SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA (Italie)
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Zinno, Ciro
  • Giannotti, Alice
  • Cedrola, Ilaria
  • Redolfi Riva, Eugenio
  • Micera, Silvestro
  • Agnesi, Filippo
  • Rizzuto, Emanuele

Abrégé

The present invention relates to the field of implantable neural interface devices and, in particular, it refers to a new implantable polymeric neural electrode for extra- or intra-neural applications, as well as to a process for the simple and economically sustainable manufacture thereof. The present invention concerns an implantable neural electrode (100) comprising a flexible main body (10) extending between a first end (10a) and a second end (10b), configured to be at least partially disposed around or inserted within a target nerve, said main body (10) comprises:- a first electrically insulating layer (11); - a second electrically insulating layer (12); and - an electrically conductive pattern (20) interposed between said first and second layers; wherein said pattern (20) comprises a first portion (31), preferably partially outwardly exposed, configured to electrically come into contact with said target nerve, and a second portion (32), preferably outwardly exposed, configured to electrically connect said electrode to an external device; wherein said first layer (11) and second layer (12) comprise at least one polymeric material and said pattern (20) comprises at least one conductive hydrogel or polymer, and wherein said first layer (11), said second layer (12), and said pattern (20) do not contain metallic nanostructures or components. The process for the manufacturing of the implantable neural electrode (100) comprises the following steps: (i) providing a first composition comprising at least one electrically insulating polymeric material or precursors thereof, and a second composition comprising at least one electrically conductive hydrogel or polymer or precursors thereof, wherein said compositions have pseudo-elastic and/or thixotropic properties and do not contain metallic nanostructures or components; (ii) depositing a layer of said first composition on a flat surface of a substrate, so as to form a first electrically insulating layer (11) of said main body (10) comprising said at least one polymeric material; (iii) depositing a layer of said second composition onto the first layer (11) obtained in step (ii) so as to form, onto said first layer, an electrically conductive pattern (20) comprising said at least one conductive hydrogel or polymer; (iv) depositing a layer of said first composition onto the pattern (20) obtained in step (iii) so as to form, onto said pattern, a second electrically insulating layer (12) of said main body (10) comprising said at least one polymeric material, wherein said depositing is carried out in such a way that at least one first portion (31) and at least one second portion (32) of the pattern (20) are left at least partially outwardly exposed; wherein all depositing steps from (ii) to (iv) are carried out by means of an extrusion printing technique.

Classes IPC  ?

  • A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
  • A61B 5/25 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet
  • A61B 5/263 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes
  • A61B 5/268 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes contenant des polymères conducteurs, p.ex. des polymères PEDOT:PSS
  • A61B 5/294 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’étude de la conduction nerveuse [NCS]
  • H05K 3/12 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché utilisant la technique de l'impression pour appliquer le matériau conducteur
  • H05K 1/02 - Circuits imprimés - Détails
  • H05K 3/36 - Assemblage de circuits imprimés avec d'autres circuits imprimés
  • A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
  • H05K 1/11 - Eléments imprimés pour réaliser des connexions électriques avec ou entre des circuits imprimés

20.

COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR DETERMINING THE FETUS VENTRICULAR VOLUME FROM DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING, AND RELATED NMR VENTRICLE VOLUME ASSESSMENT METHOD

      
Numéro d'application 18255687
Statut En instance
Date de dépôt 2021-11-29
Date de la première publication 2024-01-11
Propriétaire
  • CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Capuani, Silvia
  • Borrelli, Mattia
  • Pratesi, Giacomo
  • Di Trani, Maria Giovanna
  • Manganaro, Lucia

Abrégé

A computer-implemented method for determining a fetus ventricular volume from DWI images is provided. The computer-implemented method involves acquiring DWI images, with a pre-set voxel height, of a fetus ventricle, the acquisition being made with a single b-value selected in a range between 200 and 1000 s/mm2, selecting a ROI on each of the DWI images around the fetus ventricle, automatically clusterizing pixels in the ROI, obtaining clusterized DWI images, and calculating the fetus ventricular volume based on the number of pixels in the ROI for each of the DWI images and the pre-set voxel height. An NMR assessment system and an NMR assessment method implementing the method for determining the fetus ventricular volume are also provided.

Classes IPC  ?

  • G06T 7/00 - Analyse d'image
  • G06T 7/11 - Découpage basé sur les zones
  • G06T 7/62 - Analyse des attributs géométriques de la superficie, du périmètre, du diamètre ou du volume

21.

METHOD FOR DETERMINING THE PROGNOSTIC SCORE IN PATIENTS WITH METASTATIC RENAL CARCINOMA

      
Numéro d'application IB2023055561
Numéro de publication 2023/233310
Statut Délivré - en vigueur
Date de dépôt 2023-05-31
Date de publication 2023-12-07
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Zizzari, Ilaria Grazia
  • Nuti, Marianna
  • Rughetti, Aurelia
  • Napoletano, Chiara
  • Di Filippo, Alessandra
  • Marchetti, Paolo
  • Botticelli, Andrea

Abrégé

The present invention relates to a method for rapidly and accurately determining the prognostic score and subsequent division into risk classes, in patients with metastatic renal carcinoma by acquiring and processing immunological analyses on the patients and combining those immunological analyses with the currently used IMDC classification.

Classes IPC  ?

  • G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
  • G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne

22.

A PROCESS FOR THE PREPARATION OF A PHONOGRAPH DISC

      
Numéro d'application IB2023054865
Numéro de publication 2023/223151
Statut Délivré - en vigueur
Date de dépôt 2023-05-11
Date de publication 2023-11-23
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Lucibello, Sabrina
  • Inglese, Giovanni

Abrégé

The present invention relates to a new process for the production of a phonograph disc for analog storing, recording and/or reproduction of a sound content, as well as to a phonograph disc obtainable by means of the aforementioned process.

Classes IPC  ?

  • G11B 11/16 - Enregistrement sur, ou reproduction depuis le même support d'enregistrement, dans lesquels, pour ces deux opérations, les procédés ou les moyens sont couverts par différents groupes principaux des groupes ou par différents sous-groupes du groupe ; Supports d'enregistrement correspondants utilisant l'enregistrement par gravure, déformation ou pressage mécaniques
  • G11B 3/70 - Supports d'enregistrement caractérisés par l'emploi d'un matériau spécifié ou par leur structure; Procédés ou appareils spécialement adaptés pour fabriquer les supports d'enregistrement

23.

METHOD OF MANUFACTURING A MIXTURE OF PURE COPPER AND CARBON NANOTUBES AND OF ADDITIVE MANUFACTURING OF A NANOCOMPOSITE MATERIAL HAVING A METALLIC MATRIX OF PURE COPPER REINFORCED WITH CARBON NANOTUBES BY MEANS OF SUCH MIXTURE

      
Numéro d'application IB2023055084
Numéro de publication 2023/223238
Statut Délivré - en vigueur
Date de dépôt 2023-05-17
Date de publication 2023-11-23
Propriétaire
  • ISTITUTO NAZIONALE DI FISICA NUCLEARE (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Pettinacci, Valerio
  • Cortis, Daniele
  • Pandolfi, Francesco
  • Rago, Ilaria Carmela
  • Cavoto, Gianluca

Abrégé

The present invention concerns a method (1000) of producing a mixture of copper powders and carbon nanotubes. The method (1000) comprises the steps of: - functionalizing (1003) carbon nanotubes with a functional group such to increase the repulsive electrostatic forces among the carbon nanotubes, dispersing (1005) the functionalized carbon nanotubes in a solvent, said dispersion being carried out by means of sonication, - adding (1007) pure copper powder to the suspension obtained by the dispersion of the functionalized carbon nanotubes in the solvent in an amount such that the carbon nanotubes constitute between 0.05% and 0.5% by weight of the mixture of copper powders and carbon nanotubes, said copper powder comprising particles with a diameter comprised between 5 pm and 40 pm measured in accordance with ASTM B822 standard, and - mixing (1009) said suspension during the addition of the copper powder and until the solvent evaporates. Furthermore, the present invention also proposes a method (2000) of realizing an artefact using such a mixture of copper powders and carbon nanotubes.

Classes IPC  ?

  • B22F 10/20 - Frittage ou fusion directs
  • B22F 10/36 - Commande ou régulation des opérations des paramètres du faisceau d’énergie
  • B33Y 70/10 - Composites de différents types de matériaux, p.ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
  • C22C 1/05 - Mélanges de poudre métallique et de poudre non métallique
  • C22C 1/10 - Alliages contenant des composants non métalliques
  • C22C 26/00 - Alliages contenant du diamant

24.

Determination of the supramolecular organization of encapsulated molecules by luminescence lifetime analysis

      
Numéro d'application 18252202
Numéro de brevet 11913882
Statut Délivré - en vigueur
Date de dépôt 2021-11-08
Date de la première publication 2023-10-26
Date d'octroi 2024-02-27
Propriétaire
  • SCUOLA NORMALE SUPERIORE (Italie)
  • UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
  • Cardarelli, Francesco
  • Beltram, Fabio
  • Tentori, Paolo Maria
  • Caracciolo, Giulio
  • Pozzi, Daniela

Abrégé

A determination of supramolecular organization in a substance includes target molecules and nanocarriers at least one of which is luminescent, based on a step of collecting of lifetime decay data of at least a standard substance pure or substantially pure where a known organization state of the target molecules and the nanocarriers is pure or substantially pure; and a step of comparing the standard data and test data from a test substance.

Classes IPC  ?

25.

LOW ENERGY CONSUMPTION CONTINUOUS METHOD FOR THE PRODUCTION OF SUV, LUV AND GUV UNILAMELLAR LIPOSOMES

      
Numéro d'application IB2023052941
Numéro de publication 2023/187587
Statut Délivré - en vigueur
Date de dépôt 2023-03-24
Date de publication 2023-10-05
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • THE FIRST HOSPITAL OF CHINA MEDICAL UNIVERSITY (Italie)
Inventeur(s)
  • Stoller, Marco
  • Gao, Xinghua
  • Qi, Ruiqun
  • Zhang, Li
  • Xu, Xuegang
  • Vilardi, Giorgio

Abrégé

The present invention relates to a method for the production of SUV, LUV and/or GUV unilamellar liposomes performed using chemical synthesis and an SDR (Spinning Disk Reactor) apparatus which together allow the production of SUV, LUV and GUV unilamellar liposomes, preferably with a controlled size; the method has a low energy consumption without the need for further post-treatment steps.

Classes IPC  ?

  • B01J 13/04 - Fabrication de microcapsules ou de microbilles par des procédés physiques, p.ex. séchage, pulvérisation
  • A23P 10/30 - Mise en capsules de particules, p.ex. additifs alimentaires
  • A61K 8/11 - Compositions encapsulées
  • A61K 9/50 - Microcapsules

26.

METHOD OF EXTRACTION AND RECOVERY OF ASTAXANTHIN FROM BIOMASS

      
Numéro d'application IB2023052124
Numéro de publication 2023/170564
Statut Délivré - en vigueur
Date de dépôt 2023-03-07
Date de publication 2023-09-14
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Bravi, Marco
  • Scarsella, Marco
  • Sapone, Vittoria

Abrégé

The present invention concerns a method for the extraction and recovery of astaxanthin from biomass.

Classes IPC  ?

  • C07C 403/24 - Dérivés du cyclohexane ou d'un cyclohexène, comportant une chaîne latérale avec une partie non saturée d'au moins quatre atomes de carbone en ligne, ladite partie étant directement attachée aux cycles cyclohexane ou cyclohexène, p.ex. vitamine A, bêt ayant des chaînes latérales substituées par des cycles non aromatiques à six chaînons, p.ex. bêta-carotène

27.

APPARATUS AND METHOD FOR SAMPLING AND DETECTING A PATHOGEN IN AIR

      
Numéro d'application 18017802
Statut En instance
Date de dépôt 2021-07-29
Date de la première publication 2023-09-07
Propriétaire
  • ISTITUTO NAZIONALE DI ASTROFISICA (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (Italie)
  • UNIVERSITA' DEGLI STUDI DI MILANO (Italie)
  • POLITECNICO DI MILANO (Italie)
Inventeur(s)
  • Esposito, Francesca
  • Brucato, John Robert
  • Cozzolino, Fabio
  • Mongelluzzo, Giuseppe
  • Popa, Ciprian Lonut
  • Fornaro, Teresa
  • Meneghin, Andrea
  • Paglialunga, Daniele
  • Pareschi, Giovanni
  • De Cesare, Giampiero
  • Caputo, Domenico
  • Nascetti, Augusto
  • Costantini, Francesca
  • Lovecchio, Nicola
  • Iannascoli, Lorenzo
  • Mirasoli, Mara
  • Michelini, Elisa
  • Guardigli, Massimo
  • Clerici, Mario
  • Trabattoni, Daria
  • Biasin, Mara
  • Scaccabarozzi, Diego

Abrégé

An apparatus for sampling and detecting a pathogen in air comprising a first air sampling module, a second module for the isolation of viral RNA and a third module for amplification and detection of the viral RNA; thanks to the integration between the modules the apparatus is compact and portable and can be used for in situ sampling of air in closed environments such as ambulances or hospital rooms, air in the external environment and air exhaled by patients.

Classes IPC  ?

  • C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
  • G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
  • G01N 1/24 - Dispositifs d'aspiration
  • C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]

28.

METHOD FOR THE CHARACTERIZATION OF SHORT PEPTIDES FROM INDUSTRIAL HEMP

      
Numéro d'application EP2023054233
Numéro de publication 2023/161197
Statut Délivré - en vigueur
Date de dépôt 2023-02-20
Date de publication 2023-08-31
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • UNIVERSITÀ DEGLI STUDI DI MILANO (Italie)
Inventeur(s)
  • Capriotti, Anna Laura
  • Cavaliere, Chiara
  • Cerrato, Andrea
  • Montone, Carmela Maria
  • Piovesana, Susy
  • Laganà, Aldo
  • Lammi, Carmen
  • Arnoldi, Anna

Abrégé

Cannabis Sativa L.Cannabis Sativa L.). The present also relates to the mixture of short peptides obtained by this method.

Classes IPC  ?

  • C07K 4/10 - Peptides ayant jusqu'à 20 amino-acides dans une séquence indéterminée ou partiellement déterminée; Leurs dérivés provenant de végétaux
  • A61K 38/01 - Protéines hydrolysées; Leurs dérivés 
  • C07K 14/415 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de végétaux

29.

ORGANIC SCINTILLATOR

      
Numéro d'application IB2023051452
Numéro de publication 2023/156957
Statut Délivré - en vigueur
Date de dépôt 2023-02-17
Date de publication 2023-08-24
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE "ENRICO FERMI" (Italie)
Inventeur(s)
  • Mattiello, Leonardo
  • Patera, Vincenzo
  • Belardini, Alessandro
  • Rocco, Daniele
  • Marafini, Michela

Abrégé

1 22121281717.

Classes IPC  ?

  • C09K 11/06 - Substances luminescentes, p.ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
  • G21K 4/00 - TECHNIQUES NON PRÉVUES AILLEURS POUR MANIPULER DES PARTICULES OU DES RAYONNEMENTS IONISANTS; DISPOSITIFS D'IRRADIATION; MICROSCOPES À RAYONS GAMMA OU À RAYONS X Écrans de conversion pour transformer une distribution spatiale de particules ou de rayonnements ionisants en images visibles, p.ex. écrans fluorescents
  • G01T 1/203 - Mesure de l'intensité de radiation avec des détecteurs à scintillation le détecteur étant fait de matières plastiques

30.

LI-RICH TRANSITION METAL OXIDES MATERIAL

      
Numéro d'application 18015567
Statut En instance
Date de dépôt 2021-07-13
Date de la première publication 2023-08-10
Propriétaire
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • UNIVERSITA' DEGLI STUDI DI GENOVA (Italie)
Inventeur(s)
  • Pellegrini, Vittorio
  • Brutti, Sergio
  • Silvestri, Laura
  • Celeste, Arcangelo

Abrégé

Li-rich transition metal oxides material, useful as cathode for Li-ion batteries and having general formula Li1.2+xMn0.54Ni0.13Co0.13-x-yAlyO2; where: 0.01≤x≤0.1; 0.01≤y≤0.1; and 0.03≤x+y<0.13.

Classes IPC  ?

  • C01G 53/00 - Composés du nickel
  • H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium

31.

ELECTROCHEMICAL TYPE BIOSENSORS COMPRISING RESORCARENES

      
Numéro d'application IB2023050685
Numéro de publication 2023/144748
Statut Délivré - en vigueur
Date de dépôt 2023-01-26
Date de publication 2023-08-03
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Botta, Bruno
  • Ghirga, Francesca
  • Quaglio, Deborah
  • Calcaterra, Andrea
  • Del Plato, Cristina
  • Mazzei, Francesco
  • Polli, Francesca

Abrégé

The present invention relates to novel resorc[4]arenes, such as pre-organized structure linkers for the development of high performance electrochemical biosensors.

Classes IPC  ?

  • G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques

32.

PHARMACEUTICAL COMPOSITION FOR THE CHEMICAL INHIBITION OF TGS1 IN THE THERAPEUTIC TREATMENT OF TELOMEROPATHIES

      
Numéro d'application 17999634
Statut En instance
Date de dépôt 2021-05-24
Date de la première publication 2023-07-27
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • UNIVERSITÀ DEGLI STUDI DI TRIESTE (Italie)
Inventeur(s)
  • Raffa, Grazia Daniela
  • Cacchione, Stefano
  • Schoeftner, Stefan

Abrégé

The present invention relates to an inhibitor of the TGS1 enzyme and/or compositions comprising such inhibitor and one or more excipients for the therapeutic treatment of clinical conditions characterized and/or caused by telomeropathies.

Classes IPC  ?

  • A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides  contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p.ex. adénosine, acide adénylique
  • A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
  • G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique

33.

THERAPEUTICAL PEPTIDOMIMETIC

      
Numéro d'application IB2022062354
Numéro de publication 2023/126751
Statut Délivré - en vigueur
Date de dépôt 2022-12-16
Date de publication 2023-07-06
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
  • ASSOCIATION FRANÇAISE CONTRE LES MYOPATHIES – AFM-TELETHON (France)
Inventeur(s)
  • D'Amati, Giulia
  • Morea, Veronica
  • Pisano, Annalinda
  • Perli, Elena
  • Pignataro, Maria Gemma

Abrégé

The present invention relates to peptidomimetics of a short peptide from leucyl-tRNA synthetase, compositions comprising one or more of said peptidomimetics and their use for the treatment of syndromes caused by mutations of mt-tRNA (mitochondrial transfer RNA) genes, and medical treatments of said syndromes comprising the administration of said one or more peptidomimetics or compositions comprising the same.

Classes IPC  ?

  • A61K 38/53 - Ligases (6)
  • C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides

34.

THERAPEUTICAL PEPTIDOMIMETIC

      
Numéro de document 03240978
Statut En instance
Date de dépôt 2022-12-16
Date de disponibilité au public 2023-07-06
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
  • ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES ? AFM-TELETHON (France)
Inventeur(s)
  • D'Amati, Giulia
  • Morea, Veronica
  • Pisano, Annalinda
  • Perli, Elena
  • Pignataro, Maria Gemma

Abrégé

The present invention relates to peptidomimetics of a short peptide from leucyl-tRNA synthetase, compositions comprising one or more of said peptidomimetics and their use for the treatment of syndromes caused by mutations of mt-tRNA (mitochondrial transfer RNA) genes, and medical treatments of said syndromes comprising the administration of said one or more peptidomimetics or compositions comprising the same.

Classes IPC  ?

  • A61K 38/53 - Ligases (6)
  • C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides

35.

ELECTRODE FOR DETECTING ANALYTES, RELATIVE BIOSENSOR AND PRODUCTION METHOD

      
Numéro d'application IB2022061784
Numéro de publication 2023/105389
Statut Délivré - en vigueur
Date de dépôt 2022-12-05
Date de publication 2023-06-15
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Mazzei, Franco
  • Polli, Francesca
  • Minisola, Salvatore

Abrégé

An electrode for electrochemical detection of an analyte in a biological sample, wherein the electrode is a molded, miniaturized, carbon-based electrode and comprises ( i ) magnetic nanoparticles coated with gold or silver, comprising on the respective surface at least one free amine group or at least one free carboxyl group, the nanoparticles being adsorbed on the surface of the electrode, and ( ii ) at least one ligand capable of specifically binding to the analyte, the at least one ligand being conjugated to the nanoparticles.

Classes IPC  ?

36.

METHOD AND RELATIVE SYSTEM FOR THE DETECTION OF A VIRAL AGENT BY MICROWAVE DIELECTRIC SPECTROSCOPY

      
Numéro d'application IB2022061649
Numéro de publication 2023/100132
Statut Délivré - en vigueur
Date de dépôt 2022-12-01
Date de publication 2023-06-08
Propriétaire
  • ISTITUTO NAZIONALE DI ASTROFISICA (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • ISTITUTO SUPERIORE DI SANITA' (Italie)
  • CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
Inventeur(s)
  • Bolli, Pietro
  • Brucalassi, Anna
  • Chiarucci, Simone
  • Cresci, Luca
  • Del Vecchio, Ciro
  • Di Ninni, Paola
  • Nesti, Renzo
  • Panella, Dario
  • Tozzi, Andrea
  • Apollonio, Francesca
  • Liberti, Micaela
  • Argentini, Claudio
  • Amendola, Antonello
  • Fiorentini, Cristiano
  • Fortuna, Claudia
  • Marsili, Giulia
  • Venturi, Giulietta
  • Barucci, Marco

Abrégé

A method for detecting a viral agent comprising the steps of placing a first sample comprising an isotonic solution in a waveguide which is axially delimited by a pair of containment elements that are substantially transparent to the microwaves and define respective interfaces of the sample; transmitting a signal with frequency variable in a predetermined microwave band to the first sample; acquiring at least one dielectric parameter of the first sample as the frequency varies by means of transmission and reflection measurements; repeating the previous steps for a second sample; and performing a differential spectroscopic analysis on said parameters for assessing the presence of a viral agent in at least one of the samples.

Classes IPC  ?

  • G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c. à d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
  • G01N 33/483 - Analyse physique de matériau biologique
  • G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide

37.

MULTIDIRECTIONAL HYSTERETIC DAMPER ENDOWED WITH NEGATIVE STIFFNESS

      
Numéro d'application IB2022059325
Numéro de publication 2023/053074
Statut Délivré - en vigueur
Date de dépôt 2022-09-30
Date de publication 2023-04-06
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Salvatore, Andrea
  • Carboni, Biagio
  • Lacarbonara, Walter

Abrégé

The present invention relates to a mechanical device to be connected in series or in parallel to a structure to be protected from dynamic stresses so as to vary the mechanical features of the system and control the general dynamic behavior. In fact, such a device represents a new multi-purpose rheological element which can be employed in various applications including : (1) vibration isolation, (2) vibration absorption, (3) shock absorption, (4) energy dissipation, (5) other applications based on rheological force-movement behavior (energy harvesting, sensors and actuators).

Classes IPC  ?

  • E04H 9/02 - Bâtiments, groupes de bâtiments ou abris conçus pour résister à des situations extérieures anormales, p.ex. à des bombardements, à des séismes ou à des climats extrêmes, ou pour se protéger de ces situations résistant aux séismes ou à l'effondrement du sol
  • B60R 19/34 - Aménagements concernant le montage des pare-chocs sur les véhicules comprenant des moyens de montage susceptibles de céder conçus pour être détruits à l'impact, p.ex. du type pare-chocs global

38.

COMPOUNDS FOR USE IN THE TREATMENT OF LEUKEMIA

      
Numéro d'application 17759546
Statut En instance
Date de dépôt 2021-01-28
Date de la première publication 2023-03-09
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Fazi, Francesco
  • Masciarelli, Silvia

Abrégé

The present invention belongs to the field of cancer therapy and relates to a composition or product comprising at least one retinoid compound, at least one arsenic compound and at least one proteasome inhibitor, for use in the treatment of acute myeloid leukemia (AML) where the tumor cells are positive for the FLT3-ITD mutation.

Classes IPC  ?

  • A61K 31/203 - Acides rétinoïques
  • A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
  • A61K 31/69 - Composés du bore
  • A61K 33/36 - Arsenic; Ses composés
  • A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
  • A61K 31/375 - Acide ascorbique, c. à d. vitamine C; Ses sels
  • A61K 31/4045 - Indole-alkylamines; Leurs amides, p.ex. sérotonine, mélatonine

39.

CAD/CAM SURGICAL DEVICE AND USE THEREOF

      
Numéro d'application 17794688
Statut En instance
Date de dépôt 2021-01-22
Date de la première publication 2023-02-09
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Cassetta, Michele
  • Altieri, Federica

Abrégé

The present invention concerns a surgical device made by computer-aided design and manufacturing (CAD/CAM) and its use as a surgical guide.

Classes IPC  ?

  • A61C 7/00 - Orthodontie, c. à d. obtention ou maintien de la position désirée des dents, p.ex. par redressage, nivellement, ajustement, séparation, ou par correction des malocclusions
  • A61C 3/03 - Instruments fonctionnant par vibration
  • A61C 1/08 - Eléments de machines spécialement adaptés à la chirurgie dentaire

40.

WEARABLE AND FLEXIBLE ELECTROCHEMICAL SWEAT SENSOR CONSISTING OF A POLYMER COMPOSITE MEMBRANE CONTAINING GRAPHENE

      
Numéro d'application IB2022056525
Numéro de publication 2023/002319
Statut Délivré - en vigueur
Date de dépôt 2022-07-15
Date de publication 2023-01-26
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Sarto, Maria Sabrina
  • Bidsorkhi, Hossein Cheraghi
  • D'Aloia, Alessandro Giuseppe
  • Tamburrano, Alessio
  • Ballam, Lavanya Rani

Abrégé

A multi-composite electrochemical cell substantially consists of a thin polymer membrane comprising three different adjacent sectors (S1, S2, S3), which are made of the same appropriately seamlessly modified polymer, incorporating in said polymer one or more conductive phases, or conductive fillers, such as graphene, metal, or a combination thereof. In the first sector (S1) the polymer material incorporates graphene nanoplatelets and acts as a cathode; in the second sector (S2), interposed between the other two, the polymer material acts as an insulating spacer; in the third sector (S3) the polymer material incorporates graphene nanoplatelets and a metal filler or immersed metal contact rheophore, with negative standard reduction potential, and acts as an anode; wherein said metal filler is in the form of dispersed powder or dispersed flakes, or of a thin sheet incorporated in the polymer.

Classes IPC  ?

  • A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang

41.

MEASUREMENT SYSTEM AND METHOD OF ELECTRIC PERMITTIVITY AT 0 HZ

      
Numéro d'application IB2022055112
Numéro de publication 2022/254350
Statut Délivré - en vigueur
Date de dépôt 2022-06-01
Date de publication 2022-12-08
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s) De Bellis, Giovanni

Abrégé

A measurement method (100) of the electric permittivity (ε) at 0 Hz of a substance (1), irrespective of the aggregation state, comprising the steps of: pre-arranging (101) a rheometer (2) comprising an electrorheology module (20), provided with a fixed first plate (21) and said movable second plate (22); connecting (102) a voltage generator (3) to said rheometer (2); placing (103) the substance (1) between said first plate (21) and said second plate (22); arranging (104) said second plate (22) at a distance (D) from said first plate (21); imposing (105) said potential difference (ΔV) at 0 Hz between said first plate (21) and said second plate (22); measuring (106) a normal force (F) to which said second plate (22) is subjected; converting (108) the normal force (F) to obtain the dielectric permittivity (ε) of the substance (1).

Classes IPC  ?

  • G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
  • G01N 11/00 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement
  • G01N 27/04 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance

42.

COMPOSITIONS FOR USE IN THE PREVENTION AND/ OR TREATMENT OF INTELLECTUAL DISABILITY AND NEURODEGENERATIVE DISEASES IN A SUBJECT WITH DOWN SYNDROME

      
Numéro d'application IB2022053323
Numéro de publication 2022/238779
Statut Délivré - en vigueur
Date de dépôt 2022-04-08
Date de publication 2022-11-17
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Barone, Eugenio
  • Tramutola, Antonella
  • Perluigi, Marzia

Abrégé

Composition for use in the prevention and/or in the treatment of intellectual disability and neurodegenerative diseases in a subject with Down syndrome, wherein the composition comprises as an active agent at least one compound belonging to the class of dipeptidyl-peptidase IV (DPP4) enzyme inhibitors and also to the class of gliptins.

Classes IPC  ?

  • A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
  • A61K 31/4162 - 1,2-Diazoles condensés avec des systèmes hétérocycliques
  • A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p.ex. pipérazine
  • A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p.ex. rifampine, thiothixène
  • A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
  • A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
  • A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
  • A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
  • A61K 31/403 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil condensés avec des carbocycles, p.ex. carbazole
  • A61K 31/4164 - 1,3-Diazoles
  • A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
  • A61K 31/522 - Purines, p.ex. adénine ayant des groupes oxo liés directement à l'hétérocycle, p.ex. hypoxanthine, guanine, acyclovir
  • A61K 31/69 - Composés du bore

43.

MECHATRONIC CONTROL DEVICE

      
Numéro d'application IB2022054264
Numéro de publication 2022/238856
Statut Délivré - en vigueur
Date de dépôt 2022-05-09
Date de publication 2022-11-17
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s) Martirano, Luigi

Abrégé

An electronic electrical device (100, 100'), comprising - a first electrical conductor (31) for the input of electric current; - a second electrical conductor (32) for the output of electric current; - a first electrical control device (1') adapted to have two positions to electrically connect and disconnect the first electrical conductor (31) and the second electrical conductor (32) to/from each other; - a second electrical control device (2, 2') adapted to have two positions to electrically connect and disconnect the first electrical conductor (31) and the second electrical conductor (32) to/from each other; - first actuation means (10) comprising a digital electronic controller (11); - second actuation means (20) comprising only mechanical and/or electromechanical components; wherein the first actuation means (10) are adapted to vary the position of said first electrical control device (1) independently of said second actuation means (20); and wherein the second actuation means (20) are adapted to vary the position of said second electrical control device (2, 2') independently of said first actuation means (10).

Classes IPC  ?

  • H01H 47/00 - Circuits autres que ceux appropriés à une application particulière du relais et prévue pour obtenir une caractéristique de fonctionnement donnée ou pour assurer un courant d'excitation donné

44.

NOVEL QUINOLINE DERIVATIVES AND USES THEREOF

      
Numéro d'application IB2022054279
Numéro de publication 2022/238863
Statut Délivré - en vigueur
Date de dépôt 2022-05-09
Date de publication 2022-11-17
Propriétaire
  • ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA” (Italie)
  • UNIVERSITA' DEGLI STUDI DI TRENTO (Italie)
Inventeur(s)
  • Minucci, Saverio
  • De Wulf, Peter Arthur Irene
  • Romanenghi, Mauro
  • Cazzoli, Riccardo
  • Damizia, Michela
  • Silvestri, Romano
  • La Regina, Giuseppe
  • Coluccia, Antonio

Abrégé

The invention refers to new quinoline-4-carboxamide derivatives, pharmaceutical compositions containing thereof and the use of the same as inhibitors of Ndc80 kinetochore subcomplex-MT binding and of kinetochore-MT binding, more preferably for use in the treatment of cell proliferative disorders including cancers and drug-resistant cancer.

Classes IPC  ?

  • C07D 215/50 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 4
  • C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
  • C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
  • C07D 409/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
  • A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
  • A61P 35/00 - Agents anticancéreux

45.

INHIBITORS OF ANTIBIOTIC RESISTANCE MEDIATED BY ARNT

      
Numéro d'application 17629654
Statut En instance
Date de dépôt 2020-07-24
Date de la première publication 2022-08-18
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
  • Imperi, Francesco
  • Ascenzioni, Fiorentina
  • Mori, Mattia
  • Ghirga, Francesca
  • Quaglio, Deborah
  • Corradi, Silvia
  • Lo Sciuto, Alessandra
  • Botta, Bruno
  • Calcaterra, Andrea
  • Stefanelli, Roberta

Abrégé

The present invention relates to diterpene compounds of general formula (I) capable of contrasting the antibiotic-resistance mediated by the ArnT enzyme, to their use as a medicament, in particular for use as an adjuvant of an antibiotic therapy in the treatment of antibiotic-resistant bacterial infections. The invention relates also to associations of one or more of the compounds of formula (I) with at least another active ingredient, in particular an antibacterial agent and/or an antibiotic, and compositions comprising one or more compounds of formula (I) or the association according to the present invention and at least one pharmaceutically acceptable excipient and/or carrier as well as to products, in particular medical devices, comprising at least a compound, an association or a composition according to the present invention. Moreover, the invention relates to the use of compounds of formula (I) to sensitize a bacterium to an antibacterial agent or an antibiotic, for example, colistin (polymyxin E) or polymyxin B and to an in vivo or in vitro method for sensitizing a bacterium to an antibacterial agent or an antibiotic comprising the exposure of said bacterium to one or more compounds of formula (I) together with colistin.

Classes IPC  ?

  • C07H 15/256 - Radicaux polyterpène
  • C07C 31/137 - Alcools monohydroxyliques contenant des cycles saturés polycycliques à systèmes cycliques condensés
  • C07C 69/36 - Esters d'acide oxalique
  • C07C 69/38 - Esters d'acide malonique
  • C07C 69/40 - Esters d'acide succinique
  • C07C 69/653 - Esters d'acide acrylique; Esters d'acide méthacrylique; Esters d'acide acrylique halogéné; Esters d'acide méthacrylique halogéné
  • C07C 69/657 - Esters d'acide maléique; Esters d'acide fumarique; Esters d'acide maléique halogéné; Esters d'acide fumarique halogéné

46.

PROCESS AND KIT FOR THE IN VITRO DIAGNOSIS OF THE ANTIPHOSPHOLIPID ANTIBODY SYNDROME

      
Numéro d'application IB2022050708
Numéro de publication 2022/167901
Statut Délivré - en vigueur
Date de dépôt 2022-01-27
Date de publication 2022-08-11
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Sorice, Maurizio
  • Misasi, Roberta
  • Garofalo, Tina
  • Longo, Agostina
  • Capozzi, Antonella
  • Manganelli, Valeria
  • Recalchi, Serena
  • Riitano, Gloria

Abrégé

The present invention relates to a process to perform an in vitro diagnosis of the antiphospholipid antibody syndrome, carried out on isolated samples of the subject to be diagnosed. Furthermore, the present invention relates to a kit which allows to perform a non-invasive diagnosis of the antiphospholipid antibody syndrome from an isolated sample of the subject for whom such a diagnosis has to be made.

Classes IPC  ?

  • G01N 33/564 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes

47.

A METHOD TO ASSIST IN THE EARLY DIAGNOSIS OF PANCREATIC ADENOCARCINOMA

      
Numéro d'application 17629091
Statut En instance
Date de dépôt 2020-07-02
Date de la première publication 2022-07-28
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA (Italie)
Inventeur(s)
  • Caracciolo, Giulio
  • Pozzi, Daniela
  • Palchetti, Sara
  • Digiacomo, Luca
  • Caputo, Damiano
  • Coppola, Roberto

Abrégé

The present invention relates to a novel method for the early diagnosis of pancreatic adenocarcinoma, comprising the use of gold nanoparticles and a subsequent image analysis, a method of screening or monitoring pathological and non-pathological patients to identify pathological patients at risk of pancreatic adenocarcinoma, comprising the use of gold nanoparticles and a subsequent image analysis, a kit comprising reactants for the early diagnosis of pancreatic adenocarcinoma.

Classes IPC  ?

  • G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
  • G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
  • G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
  • G06F 17/15 - Calcul de fonction de corrélation

48.

REMOVABLE, WATERPROOF MULTI-LAYER COATING HAVING ANTIBACTERIAL PROPERTIES FOR CONTACT SURFACES AND METHOD FOR THE PREPARATION THEREOF

      
Numéro d'application IB2022050439
Numéro de publication 2022/157638
Statut Délivré - en vigueur
Date de dépôt 2022-01-19
Date de publication 2022-07-28
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Sarto, Maria Sabrina
  • Uccelletti, Daniela
  • Polimeni, Antonella
  • De Bellis, Giovanni
  • Bossu', Maurizio
  • Bidsorkhi, Hossein Cheraghi
  • Bruni, Erika
  • Bellagamba, Irene
  • Ballam, Lavanya Rani

Abrégé

A multi-layer coating with antibacterial and anti-COVID properties which is usable in various environments, including hospitals, and which can be easily deposited by spraying on different surfaces and capable of providing an effective removable barrier against pathogens and bacteria, which waterproof coating is characterized in that it uses graphene nanoparticles as an antibacterial and anti-COVID agent deposited by spraying a polymer material as a host layer on the surface to promote the dispersion and uniform surface distribution thereof, said polymer material being directly adhered by spraying to the surface to be coated or sprayed on a second polymer, in turn sprayed on the surface to be coated, which is used as an element to promote the adhesion of the first polymer forming the antibacterial and anti-COVID coating to said surface to be coated.

Classes IPC  ?

  • C09D 5/00 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, caractérisées par leur nature physique ou par les effets produits; Apprêts en pâte
  • C09D 5/16 - Peintures antisalissures; Peintures subaquatiques
  • C09D 5/02 - Peintures émulsions

49.

SEROLOGICAL TEST TO AID DIAGNOSIS OF GLIOBLASTOMA MULTIFORME

      
Numéro d'application IB2021061789
Numéro de publication 2022/130251
Statut Délivré - en vigueur
Date de dépôt 2021-12-15
Date de publication 2022-06-23
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Caracciolo, Giulio
  • Di Carlo, Angelina
  • Pozzi, Daniela
  • Digiacomo, Luca
  • Di Santo, Riccardo
  • Quagliarini, Erica

Abrégé

The invention relates to a method for the diagnosis of glioblastoma multiforme which comprises the use of graphene oxide nanoparticles and a subsequent image analysis, a method of screening or monitoring of pathological and non-pathological patients to identify pathological patients at risk of glioblastoma multiforme, which comprises the use of graphene oxide nanoparticles and subsequent image analysis, a kit comprising reagents for the early diagnosis of glioblastoma multiforme.

Classes IPC  ?

  • G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
  • G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
  • G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées

50.

COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR DETERMINING THE FETUS VENTRICULAR VOLUME FROM DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING, AND RELATED NMR VENTRICLE VOLUME ASSESSMENT METHOD

      
Numéro d'application EP2021083318
Numéro de publication 2022/117491
Statut Délivré - en vigueur
Date de dépôt 2021-11-29
Date de publication 2022-06-09
Propriétaire
  • CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Capuani, Silvia
  • Borrelli, Mattia
  • Pratesi, Giacomo
  • Di Trani, Maria Giovanna
  • Manganaro, Lucia

Abrégé

bb-value (111) selected in the range between 200 and 1000 s/mm2; B. Selecting a ROI (122,123,124,125) on each of the DWI images around the ventricle; C. Automatically clusterizing (127) the pixels in the ROI, obtaining clusterized DWI images; and D. Calculating (130) the ventricle volume based on the number of pixels in the ROI for each of the DWI images and the pre-set voxel height. The method further concerns a NMR assessment system and a NMR assessment method that uses the invention method.

Classes IPC  ?

  • G06T 7/62 - Analyse des attributs géométriques de la superficie, du périmètre, du diamètre ou du volume
  • G06T 7/00 - Analyse d'image
  • G06T 7/11 - Découpage basé sur les zones

51.

ENGINEERED LACTOCOCCUS

      
Numéro d'application 17435588
Statut En instance
Date de dépôt 2020-03-04
Date de la première publication 2022-05-19
Propriétaire UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Marchese, Cinzia
  • Angeloni, Antonio
  • Ceccarelli, Simona
  • D'Amici, Sirio

Abrégé

The present invention refers to a microorganism characterized in that it is genetically modified to express the human growth factor of keratinocytes (KGF/FGF7) or its functional orthologues, derivatives or fragments.

Classes IPC  ?

  • A61K 35/744 - Bactéries lactiques, p.ex. entérocoques, pédiocoques, lactocoques, streptocoques ou leuconostoques
  • A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
  • C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p.ex. Lactobacillus, Micromonospora

52.

DETERMINATION OF THE SUPRAMOLECULAR ORGANIZATION OF ENCAPSULATED MOLECULES BY LUMINESCENCE LIFETIME ANALYSIS

      
Numéro d'application IB2021060300
Numéro de publication 2022/097108
Statut Délivré - en vigueur
Date de dépôt 2021-11-08
Date de publication 2022-05-12
Propriétaire
  • SCUOLA NORMALE SUPERIORE (Italie)
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
  • Cardarelli, Francesco
  • Beltram, Fabio
  • Tentori, Paolo Maria
  • Caracciolo, Giulio
  • Pozzi, Daniela

Abrégé

The present invention relates to determination of supramolecular organization in a substance including target molecules and nanocarriers at least one of which is luminescent, based on a step of collecting of lifetime decay data of at least a standard substance pure or substantially pure wherein a known organization state of the target molecules and the nanocarriers is pure or substantially pure; and a step of comparing the standard data and test data from a test substance.

Classes IPC  ?

53.

RADIODRUG FOR DIAGNOSTIC/THERAPEUTIC USE IN NUCLEAR MEDICINE AND RADIO-GUIDED MEDICINE

      
Numéro d'application 17417989
Statut En instance
Date de dépôt 2020-01-08
Date de la première publication 2022-03-10
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • FONDAZIONE POLICLINICO UNIVERSIT ARIO AGOSTING GEMELLI IRCCS (Italie)
  • UNIVERSITÀ CATTOLICA DEL SACRO CUORE (Italie)
Inventeur(s)
  • Faccini, Riccardo
  • Solfaroli Camillocci, Elena
  • Rotili, Dante
  • Ciogli, Alessia
  • Cartoni, Antonella
  • Fratoddi, Ilaria
  • Venditti, Iole
  • Giordano, Alessandro
  • Maccora, Daria
  • Perotti, Germano
  • Scotognella, Teresa

Abrégé

Radio-drug suitable for performing radio-guided surgery, imaging diagnostics, radio-metabolic therapy.

Classes IPC  ?

54.

APPARATUS AND METHOD FOR SAMPLING AND DETECTING A PATHOGEN IN AIR

      
Numéro d'application IB2021056928
Numéro de publication 2022/024035
Statut Délivré - en vigueur
Date de dépôt 2021-07-29
Date de publication 2022-02-03
Propriétaire
  • ISTITUTO NAZIONALE DI ASTROFISICA (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (Italie)
  • UNIVERSITA' DEGLI STUDI DI MILANO (Italie)
  • POLITECNICO DI MILANO (Italie)
Inventeur(s)
  • Esposito, Francesca
  • Brucato, John Robert
  • Cozzolino, Fabio
  • Mongelluzzo, Giuseppe
  • Popa, Ciprian Ionut
  • Fornaro, Teresa
  • Meneghin, Andrea
  • Paglialunga, Daniele
  • Pareschi, Giovanni
  • De Cesare, Giampiero
  • Caputo, Domenico
  • Nascetti, Augusto
  • Costantini, Francesca
  • Lovecchio, Nicola
  • Iannascoli, Lorenzo
  • Mirasoli, Mara
  • Michelini, Elisa
  • Guardigli, Massimo
  • Clerici, Mario
  • Trabattoni, Daria
  • Biasin, Mara
  • Scaccabarozzi, Diego

Abrégé

An apparatus (1) for sampling and detecting a pathogen in air comprising a first air sampling module (A), a second module (B) for the isolation of viral RNA and a third module (C) for amplification and detection of the viral RNA; thanks to the integration between the modules (A, B, C) the apparatus (1) is compact and portable and can be used for in situ sampling of air in closed environments such as ambulances or hospital rooms, air in the external environment and air exhaled by patients.

Classes IPC  ?

  • C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]
  • G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
  • G01N 1/24 - Dispositifs d'aspiration

55.

LI-RICH TRANSITION METAL OXIDES MATERIAL

      
Numéro d'application IB2021056279
Numéro de publication 2022/013725
Statut Délivré - en vigueur
Date de dépôt 2021-07-13
Date de publication 2022-01-20
Propriétaire
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • UNIVERSITA' DEGLI STUDI DI GENOVA (Italie)
Inventeur(s)
  • Pellegrini, Vittorio
  • Brutti, Sergio
  • Silvestri, Laura
  • Celeste, Arcangelo

Abrégé

1.2+x0.540.130.13-x-yy22; where: 0.01≤x≤0.1; 0.01≤y≤0.1; and 0.03≤x+y<0.13.

Classes IPC  ?

  • C01G 53/00 - Composés du nickel
  • H01M 4/505 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de manganèse d'oxydes ou d'hydroxydes mixtes contenant du manganèse pour insérer ou intercaler des métaux légers, p.ex. LiMn2O4 ou LiMn2OxFy
  • H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p.ex. LiNiO2, LiCoO2 ou LiCoOxFy

56.

PHARMACEUTICAL COMPOSITION FOR THE CHEMICAL INHIBITION OF TGS1 IN THE THERAPEUTIC TREATMENT OF TELOMEROPATHIES

      
Numéro de document 03180376
Statut En instance
Date de dépôt 2021-05-24
Date de disponibilité au public 2021-12-02
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • UNIVERSITA DEGLI STUDI DI TRIESTE (Italie)
Inventeur(s)
  • Raffa, Grazia Daniela
  • Cacchione, Stefano
  • Schoeftner, Stefan

Abrégé

The present invention relates to an inhibitor of the TGS1 enzyme and/or compositions comprising such inhibitor and one or more excipients for the therapeutic treatment of clinical conditions characterized and/or caused by telomeropathies.

Classes IPC  ?

  • A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides  contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p.ex. adénosine, acide adénylique
  • A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie

57.

PHARMACEUTICAL COMPOSITION FOR THE CHEMICAL INHIBITION OF TGS1 IN THE THERAPEUTIC TREATMENT OF TELOMEROPATHIES

      
Numéro d'application IB2021054484
Numéro de publication 2021/240340
Statut Délivré - en vigueur
Date de dépôt 2021-05-24
Date de publication 2021-12-02
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • UNIVERSITÀ DEGLI STUDI DI TRIESTE (Italie)
Inventeur(s)
  • Raffa, Grazia Daniela
  • Cacchione, Stefano
  • Schoeftner, Stefan

Abrégé

The present invention relates to an inhibitor of the TGS1 enzyme and/or compositions comprising such inhibitor and one or more excipients for the therapeutic treatment of clinical conditions characterized and/or caused by telomeropathies.

Classes IPC  ?

  • A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides  contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p.ex. adénosine, acide adénylique
  • A61K 33/22 - Composés du bore
  • A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
  • A61P 19/00 - Médicaments pour le traitement des troubles du squelette
  • A61P 35/00 - Agents anticancéreux
  • A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
  • A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes

58.

NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

      
Numéro d'application 17397509
Statut En instance
Date de dépôt 2021-08-09
Date de la première publication 2021-11-25
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
  • Botta, Bruno
  • Screpanti, Isabella
  • Tottone, Luca
  • Zhdanoskaya, Nadezda
  • Ingallina, Cinzia
  • Giulimondi, Francesca
  • Quaglio, Deborah
  • Palermo, Rocco
  • Mori, Mattia
  • Ghirga, Francesca

Abrégé

Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL). Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).

Classes IPC  ?

  • C07D 309/32 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
  • A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
  • C07C 49/248 - Composés non saturés comportant des groupes cétone liés à des atomes de carbone acycliques contenant des groupes hydroxyle contenant des cycles aromatiques à six chaînons avec insaturation autre que celle des cycles aromatiques

59.

PROCESS FOR THE SYNTHESIS AND PRODUCTION OF NANO- OR MICRO-ZEOLITES USING A ROTATING DISC REACTOR

      
Numéro d'application IB2021052615
Numéro de publication 2021/198899
Statut Délivré - en vigueur
Date de dépôt 2021-03-30
Date de publication 2021-10-07
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
  • Vilardi, Giorgio
  • Stoller, Marco
  • Ferrini, Mauro
  • Saviano, Giovanna
  • Santonicola, Mariagabriella

Abrégé

The present invention relates to an industrial production process performed using a chemical synthesis and Spinning Disk Reactor (SDR) apparatus which together make it possible to produce crystalline synthetic nanostructure d or microstructured zeolites or crystalline synthetic nanostructure d or micro structure d zeolite-type (zeotype) materials without the addition of other chemical agents (or templates) to guide deposition, which would have to be removed by appropriate post-treatment and which would render the zeolites or zeotype material unsuitable for use in biomedical applications (separation treatment with heavy liquids.

Classes IPC  ?

  • C01B 39/02 - Zéolites aluminosilicates cristallines; Leurs composés isomorphes; Leur préparation directe; Leur préparation à partir d'un mélange réactionnel contenant une zéolite cristalline d'un autre type, ou à partir de réactants préformés; Leur post-traitement
  • C01B 39/14 - Type A

60.

Method for making prestressed shells having tunable bistability

      
Numéro d'application 17254003
Numéro de brevet 11880636
Statut Délivré - en vigueur
Date de dépôt 2019-06-20
Date de la première publication 2021-09-16
Date d'octroi 2024-01-23
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
  • Vidoli, Stefano
  • Brunetti, Matteo

Abrégé

In a method for manufacturing prestressed shells having tunable bistability, in order to determine the appropriate prestress to be applied to the bistable structure/shell, it provides: clamping a shell by applying a predetermined curvature on a portion of its edge; defining a discrete shell model dependent on a small number of configuration parameters q_i, (i<5), by projecting the non-linear shell model of Marguerre-von Kármán onto an appropriate finite dimensional space so that the projection does not significantly alter the strain elastic energy; tracing the stability maps in the space of the design parameters by minimizing the discrete representation of the strain elastic energy E(q_i;p_i) thus obtained; and choosing the design parameters providing the prestress needed to obtain the desired response in terms of project requirements.

Classes IPC  ?

  • B29C 70/54 - Façonnage de matières composites, c. à d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p.ex. des inserts comprenant uniquement des renforcements, p.ex. matières plastiques auto-renforçantes opération de façonnage des matières composites comprenant uniquement des renforcements - Parties constitutives, détails ou accessoires; Opérations auxiliaires
  • B64F 5/10 - Fabrication ou assemblage d’aéronefs, p.ex. gabarits à cet effet
  • G06F 111/10 - Modélisation numérique
  • B29L 31/30 - Véhicules, p.ex. bateaux ou avions, ou éléments de leur carrosserie
  • G06F 30/10 - CAO géométrique

61.

SUPPORT SYSTEM FOR AN EVACUATION OF A USER FROM A TUNNEL

      
Numéro d'application IB2021051241
Numéro de publication 2021/161281
Statut Délivré - en vigueur
Date de dépôt 2021-02-15
Date de publication 2021-08-19
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Fusco, Ciro
  • Lombardi, Mara
  • Di Mascio, Paola
  • Rossi, Giuliano
  • Sciaretta, Nicolò
  • Cantisani, Giuseppe

Abrégé

A support system (100) for an evacuation of a user from a road or railway tunnel (102), which includes a first pedestrian evacuation lane (108) between a first and a second emergency exit (104, 106), is described. The support system comprises several radiofrequency devices (110) each associated with a predetermined unique identifier and each installed in a predetermined tunnel position. Each radiofrequency device has a certain coverage area (112) wherein it transmits support information to a user device (U) in the coverage area. The radiofrequency devices (110) are installed on an internal wall (114) of the tunnel (102) so that the whole of the coverage areas (112) covers the entire first pedestrian evacuation lane (108). The user device includes a storage means which stores the association between the predetermined unique identifier and the predetermined tunnel position of the radiofrequency devices (110). The support information includes a first location data item (MAJOR) comprising the predetermined unique identifier of the radiofrequency device (110) which transmits the support information to the user device (U). The user device (U) determines its position in the tunnel (102) as a function of the location data item (MAJOR) comprised in the received support information.

Classes IPC  ?

  • E21F 11/00 - Dispositifs de sauvetage ou autres dispositifs de sécurité, p.ex. refuges ou itinéraires d'échappement
  • E21F 17/18 - Adaptations particulières des dispositifs de signalisation ou d'alarme

62.

COMPOUNDS FOR USE IN THE TREATMENT OF LEUKEMIA

      
Numéro d'application IB2021050674
Numéro de publication 2021/152501
Statut Délivré - en vigueur
Date de dépôt 2021-01-28
Date de publication 2021-08-05
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Fazi, Francesco
  • Masciarelli, Silvia

Abrégé

The present invention belongs to the field of cancer therapy and relates to a composition or product comprising at least one retinoid compound, at least one arsenic compound and at least one proteasome inhibitor, for use in the treatment of acute myeloid leukemia (AML) where the tumor cells are positive for the FLT3-ITD mutation.

Classes IPC  ?

  • A61K 31/203 - Acides rétinoïques
  • A61K 31/69 - Composés du bore
  • A61K 33/36 - Arsenic; Ses composés
  • A61K 38/05 - Dipeptides
  • A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
  • A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie

63.

CAD/CAM SURGICAL DEVICE AND USE THEREOF

      
Numéro d'application IB2021050498
Numéro de publication 2021/149001
Statut Délivré - en vigueur
Date de dépôt 2021-01-22
Date de publication 2021-07-29
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Cassetta, Michele
  • Altieri, Federica

Abrégé

The present invention concerns a surgical device made by computer-aided design and manufacturing (CAD/CAM) and its use as a surgical guide.

Classes IPC  ?

  • A61C 7/00 - Orthodontie, c. à d. obtention ou maintien de la position désirée des dents, p.ex. par redressage, nivellement, ajustement, séparation, ou par correction des malocclusions
  • A61C 1/08 - Eléments de machines spécialement adaptés à la chirurgie dentaire
  • A61C 3/03 - Instruments fonctionnant par vibration

64.

A NEW METHOD FOR DIAGNOSING A THYROID TUMOUR AND KIT THEREOF

      
Numéro d'application IB2020061699
Numéro de publication 2021/116938
Statut Délivré - en vigueur
Date de dépôt 2020-12-09
Date de publication 2021-06-17
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Filetti, Sebastiano
  • Durante, Cosimo
  • Verrienti, Antonella
  • Sponziello, Marialuisa
  • Grani, Giorgio

Abrégé

in vitroin vitro diagnosis of a thyroid tumour, comprising the steps of identifying the presence of gene mutations and identifying the expression of the levels of a specific miRNA, and relative kit.

Classes IPC  ?

  • C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

65.

MiRNAs for treatment and in vitro diagnosis of drug resistant tumors

      
Numéro d'application 17046478
Numéro de brevet 11492671
Statut Délivré - en vigueur
Date de dépôt 2019-04-10
Date de la première publication 2021-05-20
Date d'octroi 2022-11-08
Propriétaire
  • ISTITUTI FISIOTERAPICI OSPITALIERI (Italie)
  • ISTITUTO NAZIONALE TUMORI I.R.C.C.S. “FONDAZIONE G. PASCALE” (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
  • Ciliberto, Gennaro
  • Ascierto, Paolo Antonio
  • Fattore, Luigi
  • Botti, Gerardo
  • Mancini, Rita

Abrégé

miRNAs for in vitro diagnosis of resistance of tumors to BRAF/MEK pathway (also named as MAPK 5 pathway) inhibiting drugs and for treatment of tumors which are treated with said drugs, such as melanoma, by stimulating or inhibiting the expression of down-regulated or up-regulated miRNAs, respectively.

Classes IPC  ?

  • C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
  • C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
  • A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 

66.

USE OF ESCULENTIN AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF CYSTIC FIBROSIS

      
Numéro de document 03156051
Statut En instance
Date de dépôt 2020-10-09
Date de disponibilité au public 2021-04-22
Propriétaire
  • UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • FONDAZIONE PER LA RICERCA SULLA FIBROSI CISTICA - ONLUS (Italie)
  • ISTITUTO GIANNINA GASLINI (Italie)
Inventeur(s)
  • Mangoni, Maria Luisa
  • Ferrera, Loretta

Abrégé

Are disclosed pharmaceutical compositions comprising as active ingredients Esculentin-1a(1-21)NH2 and/or Esculentin diastereomer Esc(1-21)-1c for use for restoring dysregulation of water and/or ions content and/or composition of the periciliary liquid due to mutations of the CFTR gene encoding for Cystic fibrosis transmembrane conductance regulator (CFTR) and for use for the treatment of cystic fibrosis.

Classes IPC  ?

  • A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
  • A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
  • A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
  • C07K 14/46 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés

67.

USE OF ESCULENTIN AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF CYSTIC FIBROSIS

      
Numéro d'application EP2020078394
Numéro de publication 2021/074025
Statut Délivré - en vigueur
Date de dépôt 2020-10-09
Date de publication 2021-04-22
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
  • FONDAZIONE PER LA RICERCA SULLA FIBROSI CISTICA – ONLUS (Italie)
  • ISTITUTO GIANNINA GASLINI (Italie)
Inventeur(s)
  • Mangoni, Maria Luisa
  • Ferrera, Loretta

Abrégé

22 and/or Esculentin diastereomer Esc(1-21)-1c for use for restoring dysregulation of water and/or ions content and/or composition of the periciliary liquid due to mutations of the CFTR gene encoding for Cystic fibrosis transmembrane conductance regulator (CFTR) and for use for the treatment of cystic fibrosis.

Classes IPC  ?

  • A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
  • A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
  • C07K 14/00 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés

68.

Composition for use in the finishing, preservation, restoration of manufactures

      
Numéro d'application 16769875
Numéro de brevet 11773533
Statut Délivré - en vigueur
Date de dépôt 2018-11-23
Date de la première publication 2021-04-15
Date d'octroi 2023-10-03
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
  • Bianco, Armandodoriano
  • Serafini, Ilaria
  • Cavallaro, Giuseppe
  • Lazzara, Giuseppe

Abrégé

−1 measured at 25.0±0.1° C., kit and method for finishing and/or preservation and/or restoration and/or renovation and/or repairing and/or consolidation of manufactures, in particular ancient manufactures are disclosed.

Classes IPC  ?

  • D21H 23/66 - Traitement de papier discontinu, p.ex. feuilles, flans ou rouleaux
  • D21H 25/02 - Traitement chimique ou biochimique
  • D06M 15/03 - Polysaccharides ou leurs dérivés
  • D06M 15/15 - Protéines ou leurs dérivés
  • D06M 23/00 - Traitement des fibres, fils, filés, tissus ou articles fibreux faits de ces matières, caractérisé par le procédé
  • D21H 25/18 - Post-traitement du papier non prévu dans les groupes de vieux papiers tels que des livres ou des documents, p.ex. restauration

69.

Method and system for the measurement of haemodynamic indices

      
Numéro d'application 16969341
Numéro de brevet 11963818
Statut Délivré - en vigueur
Date de dépôt 2019-02-14
Date de la première publication 2021-02-18
Date d'octroi 2024-04-23
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA LA SAPIENZA (Italie)
Inventeur(s) Sterpetti, Antonio Vittorio

Abrégé

Method and relative system for the measurement of haemodynamic indices, said method comprising: acquiring an ultrasound image of at least one segment of an arterial vessel; identifying in said image at least one sample volume; obtaining a time series indicating the blood velocity, or velocity signal (9), in said sample volume and in at least one cardiac cycle; calculating, by means of a processor, a first area (4) equal to the area subtended by the velocity signal (9) between the sample (6) relating to the instant of systole start of said at least one cardiac cycle and the sample (7) of systolic peak; calculating, by means of a processor, a second area (5) subtended by the velocity signal (9) between the sample (7) of systolic peak and the sample (8) relating to the instant of end diastole of said at least one cardiac cycle; calculating the relationship between the second area (5) and the first area (4); selecting a time instant of interest in said at least one cardiac cycle; obtaining the spatial distribution of the velocity in said time instant of interest, or instantaneous distribution of the velocity; identifying the maximum value and the minimum value of the instantaneous distribution of the velocity; and calculating the relationship between the maximum value and the minimum value.

Classes IPC  ?

  • A61B 8/06 - Mesure du débit sanguin
  • A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
  • A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
  • A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p.ex. en utilisant des cathéters
  • G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne

70.

A METHOD TO ASSIST IN THE EARLY DIAGNOSIS OF PANCREATIC ADENOCARCINOMA

      
Numéro d'application IB2020056251
Numéro de publication 2021/014243
Statut Délivré - en vigueur
Date de dépôt 2020-07-02
Date de publication 2021-01-28
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA (Italie)
Inventeur(s)
  • Caracciolo, Giulio
  • Pozzi, Daniela
  • Palchetti, Sara
  • Digiacomo, Luca
  • Caputo, Damiano
  • Coppola, Roberto

Abrégé

The present invention relates to a novel method for the early diagnosis of pancreatic adenocarcinoma, comprising the use of gold nanoparticles and a subsequent image analysis, a method of screening or monitoring pathological and non-pathological patients to identify pathological patients at risk of pancreatic adenocarcinoma, comprising the use of gold nanoparticles and a subsequent image analysis, a kit comprising reactants for the early diagnosis of pancreatic adenocarcinoma.

Classes IPC  ?

  • G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
  • G16B 40/20 - Analyse de données supervisée

71.

INHIBITORS OF ANTIBIOTIC RESISTANCE MEDIATED BY ARN T

      
Numéro d'application IB2020057019
Numéro de publication 2021/014422
Statut Délivré - en vigueur
Date de dépôt 2020-07-24
Date de publication 2021-01-28
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
  • Imperi, Francesco
  • Ascenzioni, Fiorentina
  • Mori, Mattia
  • Ghirga, Francesca
  • Quaglio, Deborah
  • Corradi, Silvia
  • Lo Sciuto, Alessandra
  • Botta, Bruno
  • Calcaterra, Andrea
  • Stefanelli, Roberta

Abrégé

The present invention relates to diterpene compounds of general formula (I) capable of contrasting the antibiotic-resistance mediated by the ArnT enzyme, to their use as a medicament, in particular for use as an adjuvant of an antibiotic therapy in the treatment of antibiotic-resistant bacterial infections. The invention relates also to associations of one or more of the compounds of formula (I) with at least another active ingredient, in particular an antibacterial agent and/or an antibiotic, and compositions comprising one or more compounds of formula (I) or the association according to the present invention and at least one pharmaceutically acceptable excipient and/or carrier as well as to products, in particular medical devices, comprising at least a compound, an association or a composition according to the present invention. Moreover, the invention relates to the use of compounds of formula (I) to sensitize a bacterium to an antibacterial agent or an antibiotic, for example, colistin (polymyxin E) or polymyxin B and to an in vivo or in vitro method for sensitizing a bacterium to an antibacterial agent or an antibiotic comprising the exposure of said bacterium to one or more compounds of formula (I) together with colistin.

Classes IPC  ?

  • A61K 31/215 - Esters, p.ex. nitroglycérine, sélénocyanates d'acides carboxyliques
  • A61K 31/7028 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques
  • A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
  • A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
  • A61P 31/04 - Agents antibactériens
  • A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
  • A61L 15/44 - Médicaments
  • C07C 13/32 - Hydrocarbures polycycliques ou leurs dérivés hydrocarbonés acycliques à cycles condensés

72.

Esculentin 1a derivatives and uses thereof

      
Numéro d'application 16912944
Numéro de brevet 11110195
Statut Délivré - en vigueur
Date de dépôt 2020-06-26
Date de la première publication 2020-10-15
Date d'octroi 2021-09-07
Propriétaire
  • UNIVERSITY OF HOUSTON SYSTEM (USA)
  • UNIVERSITA' DEGLI STUDI DI ROMA LA SAPIENZA (Italie)
Inventeur(s)
  • Mcdermott, Alison
  • Mangoni, Maria Luisa

Abrégé

Provided herein are synthetic antibacterial peptides that have a sequence at least 80% identical to a sequence shown in SEQ ID NO: 2 or the diastereomer thereof with a sequence shown in SEQ ID NO: 3 or pharmaceutical compositions thereof. Also provided are methods for stimulating wound healing via the synthetic antibacterial peptides and for forming an antimicrobial coating on contact lenses. In addition a device is provided that has a surface with a coating of the synthetic antibacterial peptides.

Classes IPC  ?

  • A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
  • A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
  • A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
  • C07K 14/46 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés
  • A61L 12/14 - Procédés ou appareils pour la désinfection ou la stérilisation des lentilles de contact; Accessoires à cet effet utilisant des substances chimiques des composés organiques non couverts par les groupes ou
  • A61P 27/02 - Agents ophtalmiques
  • A61K 38/04 - Peptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminée; Leurs dérivés
  • B29D 11/00 - Fabrication d'éléments optiques, p.ex. lentilles ou prismes
  • G02B 1/04 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES Éléments optiques caractérisés par la substance dont ils sont faits; Revêtements optiques pour éléments optiques faits de substances organiques, p.ex. plastiques

73.

STABLE SYSTEM FOR THE IN VITRO CULTURE OF CEREBELLAR GRANULE CELL PRECURSORS (GCP), STABLE METHOD FOR THE IN VITRO CULTURE OF SAID CELLS AND USE OF SAID SYSTEM OR METHOD FOR IN VITRO CULTURE

      
Numéro d'application IB2020052513
Numéro de publication 2020/194141
Statut Délivré - en vigueur
Date de dépôt 2020-03-19
Date de publication 2020-10-01
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
  • Giannini, Giuseppe
  • Colicchia, Valeria
  • Capalbo, Carlo
  • Fabretti, Francesca
  • Di Giulio, Stefano
  • Belardinilli, Francesca
  • Petroni, Marialaura
  • Roncero, Maria Sahùn

Abrégé

in vitroin vitro in vitro in vitro models for study of the pathophysiology of cerebellar granules or use of the above-mentioned culture system or method of culture for use in gene therapy and cell therapy approaches to cerebellar diseases caused by damage or neurodegeneration.

Classes IPC  ?

74.

ENGINEERED LACTOCOCCUS

      
Numéro d'application EP2020055705
Numéro de publication 2020/178345
Statut Délivré - en vigueur
Date de dépôt 2020-03-04
Date de publication 2020-09-10
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Marchese, Cinzia
  • Angeloni, Antonio
  • Ceccarelli, Simona
  • D'Amici, Sirio

Abrégé

The present invention refers to a microorganism characterized in that it is genetically modified to express the human growth factor of keratinocytes (KGF / FGF7) or its functional orthologues, derivatives or fragments.

Classes IPC  ?

  • A61K 38/18 - Facteurs de croissance; Régulateurs de croissance
  • A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
  • A23L 33/135 - Bactéries ou leurs dérivés, p.ex. probiotiques
  • A61K 35/741 - Probiotiques
  • A61K 35/744 - Bactéries lactiques, p.ex. entérocoques, pédiocoques, lactocoques, streptocoques ou leuconostoques
  • A61K 35/747 - Lactobacilles, p.ex. L. acidophilus ou L. brevis

75.

RADIODRUG FOR DIAGNOSTIC/THERAPEUTIC USE IN NUCLEAR MEDICINE AND RADIO-GUIDED MEDICINE

      
Numéro d'application IB2020050105
Numéro de publication 2020/144586
Statut Délivré - en vigueur
Date de dépôt 2020-01-08
Date de publication 2020-07-16
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS (Italie)
  • UNIVERSITÀ CATTOLICA DEL SACRO CUORE (Italie)
Inventeur(s)
  • Faccini, Riccardo
  • Solfaroli Camillocci, Elena
  • Rotili, Dante
  • Ciogli, Alessia
  • Cartoni, Antonella
  • Fratoddi, Ilaria
  • Venditti, Iole
  • Giordano, Alessandro
  • Maccora, Daria
  • Perotti, Germano
  • Scotognella, Teresa

Abrégé

Radio-drug suitable for performing radio-guided surgery, imaging diagnostics, radio-metabolic therapy.

Classes IPC  ?

76.

PROCESS FOR SYNTHESIS OF EXOSOMES CONTAINING THE HEAT SHOCK PROTEIN HSP60 AND THEIR USE FOR THE TREATMENT OF MUSCULAR ATROPHY AND CACHEXIA

      
Numéro d'application IB2019058337
Numéro de publication 2020/075004
Statut Délivré - en vigueur
Date de dépôt 2019-10-01
Date de publication 2020-04-16
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI PALERMO (Italie)
  • SORBONNE UNIVERSITE (France)
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
  • INSERM INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (France)
  • UNIVERSITÀ TELEMATICA ECAMPUS (Italie)
  • UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
  • Gasco, Paolo
  • Multhoff, Gabriele
  • Adamo, Sergio
  • Coletti, Dario
  • Macaluso, Filippo
  • D'Amico, Daniela
  • Trovato, Eleonora
  • Farina, Felicia
  • Cappello, Francesco
  • Campanella, Claudia
  • Marino Gammazza, Antonella
  • Barone, Rosario

Abrégé

A process for the in vitro preparation of vesicles containing as an active ingredient the heat shock protein of 60 kDa Hsp60 and the use of vesicles as a medicament in particular for the treatment of muscular atrophy or sarcopenia and of cachexia is described.

Classes IPC  ?

  • C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
  • A61K 9/50 - Microcapsules
  • A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains

77.

Curare Curantes

      
Numéro d'application 018217028
Statut Enregistrée
Date de dépôt 2020-03-27
Date d'enregistrement 2020-07-11
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Classes de Nice  ?
  • 41 - Éducation, divertissements, activités sportives et culturelles
  • 42 - Services scientifiques, technologiques et industriels, recherche et conception
  • 44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
  • 45 - Services juridiques; services de sécurité; services personnels pour individus

Produits et services

Providing cultural activities; Cultural services; Training; Organisation of sporting events; Publishing, reporting, and writing of texts; Training in the field of medicine; Teaching services relating to the medical field; Organization of seminars and conventions in the field of medicine; Conducting educational support programmes for carers; Providing continuing nursing education courses; Provision of keep fit facilities; Supervision of physical exercise; Provision of information relating to sports; Health club services [health and fitness training]; Exercise [fitness] training services; Physical fitness instruction; Recreation and training services; Sporting and recreational activities; Exercise [fitness] advisory services; Instruction courses relating to physical fitness; Consultancy relating to physical fitness training; Health and fitness training; Instruction in group exercise; Education services relating to health; Training services relating to occupational health; Instruction in body grooming; Education in the field of occupational health and safety; Vocational education relating to avoidance of health related problems; Education and training services in the field of occupational health and safety; Bodywork therapy instruction; Health and wellness training; Entertainment services in the nature of organizing social entertainment events; Personal coaching [training]. Providing scientific information in the field of medical disorders and their treatment; Scientific research for medical purposes; Scientific research in the field of social medicine; Information technology services for the pharmaceutical and healthcare industries; Scientific research for medical purposes in the area of cancerous diseases; Consultancy relating to research and development in the field of therapeutics; Clinical research; Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Providing information on clinical studies via an interactive website; Medical research; Clinical trials; Rental of science and technology equipment; Provision of information and data relating to medical and veterinary research and development. Medical services; Rental of equipment for human healthcare; Dentistry; Mental health services; Opticians' services; Human healthcare services; Medical screening; Medical clinic services; Provision of medical services; Medical examination of individuals; Medical equipment rental; Physician services; Conducting of medical examinations; Compilation of medical reports; Regenerative medicine services; Residential medical treatment services; Medical screening relating to the heart; Medical testing services relating to the diagnosis and treatment of disease; Providing medical support in the monitoring of patients receiving medical treatments; Medical assistance consultancy provided by doctors and other specialized medical personnel; Medical analysis services for diagnostic and treatment purposes provided by medical laboratories; Providing nutritional information about food for medical weight loss purposes; Providing nutritional information about drinks for medical weight loss purposes; Charitable services, namely, providing medical services to needy persons; Advisory services relating to medical apparatus and instruments; Consultancy and information services relating to medical products; Providing news and information in the field of medicine; Providing online medical record services other than dentistry; Medical and healthcare services; Medical health assessment services; Advisory services relating to medical services; Advisory services relating to medical problems; Medical treatment services; Medical services in the field of treatment of chronic pain; Medical treatment services provided by clinics and hospitals; Provision of information relating to medicine; Counselling relating to the psychological treatment of medical ailments; Counselling relating to the psychological relief of medical ailments; Dispensing of pharmaceuticals; Home-visit nursing care; Assisting individuals to stop smoking; Health advice and information services; Nutrition consultancy; Dietetic advisory services; Consulting services relating to health care; Advice relating to the personal welfare of elderly people [health]; Advice relating to allergies; Nutrition counseling; Health screening; Physiotherapy; Providing breastfeeding information; Providing health care information by telephone; Providing information relating to physical examinations; Providing information relating to dietary and nutritional supplements; Providing smoking cessation treatment services; Providing weight loss program services; Provision of health care services in domestic homes; Health assessment surveys; Massage; Monitoring of patients; Genetic counseling; Counseling relating to occupational therapy; Therapeutical pilates; Family planning; Health risk assessment surveys; Rehabilitation of alcohol addicted patients; Rehabilitation of narcotic addicted patients; Rehabilitation of drug addicted patients; Physical rehabilitation; Health centre services; Laboratory analysis services relating to the treatment of persons; Home health care services; Health care in the nature of health maintenance organizations; Health care services offered through a network of health care providers on a contract basis; Lactation consulting services; Cryotherapy services; Postnatal care services for women; Electro therapy services for physiotherapy; Stress management services; Information services relating to health care; Medical information services provided via the Internet; Meditation services; Occupational therapy and rehabilitation; Occupational therapy services; Pharmaceutical services; Weight reduction services; Health care relating to therapeutic massage; Health care relating to remedial exercise; Therapy services; Music therapy for physical, psychological and cognitive purposes; Thalassotherapy; Fitness testing; Therapeutic treatment of the face; Therapeutic treatment of the body; Professional consultancy relating to health care; Addiction treatment services; Consultancy in the field of body and beauty care; Personality assessment services [mental health services]; Development of individual physical rehabilitation programmes; Providing physical rehabilitation facilities; Providing mental rehabilitation facilities. Consultancy services relating to health and safety; Information services relating to health and safety; Consultancy on regulations on safety at work; Consulting in the field of personal relationships; Health and safety risk assessment services; Marriage guidance counselling; Bereavement support; Bereavement counselling; Providing patient advocate services to hospital patients and patients in long term care facilities; Providing personal support services for cancer patients and their families; Providing personal support services for families of patients with life threatening disorders; Provision of emotional support to families; Online social networking services accessible by means of downloadable mobile applications; Online social networking services.

78.

ANAEROBIC DIGESTION WITH A DYNAMIC RECIRCULATION OF DIGESTATE

      
Numéro d'application IB2019056702
Numéro de publication 2020/031094
Statut Délivré - en vigueur
Date de dépôt 2019-08-07
Date de publication 2020-02-13
Propriétaire
  • UNIVERSITA' CA' FOSCARI (Italie)
  • UNIVERSITA' DEGLI STUDI DI VERONA (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Gottardo, Marco
  • Pavan, Paolo
  • Cavinato, Cristina
  • Micolucci, Federico
  • Bolzonella, David
  • Majone, Mauro
  • Valentino, Francesco

Abrégé

The object of the present invention consists of a method for optimizing the biological production of gaseous hydrogen and volatile fatty acids (VFA) by means of the anaerobic digestion process with separate phases. This optimization is achieved by controlling the pH of the reaction medium in the fermentation reactor through the recirculation of the digestate exiting the digestion reactor. The recirculation ratio is managed by an algorithm that automatically establishes the recirculation flow rate for maintaining the pH in the fermentation reactor at a value close to the optimal one through inputs coming from probes inside the two reactors and at the same time prevents an excessive accumulation of ammonia in the system.

Classes IPC  ?

  • C12P 3/00 - Préparation d'éléments ou de composés inorganiques à l'exception du dioxyde de carbone
  • C12P 5/02 - Préparation des hydrocarbures acycliques
  • C12P 7/00 - Préparation de composés organiques contenant de l'oxygène
  • C12P 7/40 - Préparation de composés organiques contenant de l'oxygène contenant un groupe carboxyle
  • C12P 7/64 - Graisses; Huiles; Cires de type ester; Acides gras supérieurs, c. à d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyle; Huiles ou graisses oxydées
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p.ex. fermenteurs commandés automatiquement

79.

METHOD FOR THE REALISATION OF PRESTRESSED SHELLS WITH A CONTROLLED BISTABILITY

      
Numéro d'application IB2019055214
Numéro de publication 2019/244096
Statut Délivré - en vigueur
Date de dépôt 2019-06-20
Date de publication 2019-12-26
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Vidoli, Stefano
  • Brunetti, Matteo

Abrégé

design parameters pii = {hii =1,2...;mii =1,2...;chii , mii cqii > (i < 5)E(qii , pii )FF22 ≤ F ≤ F11 F > Ft11 1 - changing the critical transition loads also during the operation of the structure.

Classes IPC  ?

  • B64C 3/44 - Variation de la courbure
  • B64C 9/02 - Montage ou supports de ces surfaces
  • B64C 27/72 - Dispositifs d'action sur les pales
  • B64C 3/48 - Variation de la courbure par parties semi-mobiles des structures d'ailes

80.

SYSTEM CONFIGURED TO MONITOR THE MOTOR ACTIVITY OF A PERSON'S LOWER LIMBS AND METHOD THEREOF

      
Numéro d'application IT2019050143
Numéro de publication 2019/244186
Statut Délivré - en vigueur
Date de dépôt 2019-06-18
Date de publication 2019-12-26
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s) Irrera, Fernanda

Abrégé

The present invention relates to a monitoring system for monitoring the motor activity of a persons's lower limbs. In particular, said system comprises a first electronic device which is a slave device (1) and a second electronic device which is a master device. Said slave device (1) and said master device (2) acquire data and cooperate to each other so that the master device (2) calculates at least one index, on the basis of the data acquired by each electronic device, in order to monitor the motor activity. The present invention relates also to a method for monitoring the motor activity of a person's lower limbs.

Classes IPC  ?

  • G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales

81.

SAPIENZA UNIVERSITA' EDITRICE STVDIVM VRBIS

      
Numéro d'application 018168705
Statut Enregistrée
Date de dépôt 2019-12-17
Date d'enregistrement 2020-05-22
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Classes de Nice  ?
  • 09 - Appareils et instruments scientifiques et électriques
  • 14 - Métaux précieux et leurs alliages; bijouterie; horlogerie
  • 16 - Papier, carton et produits en ces matières
  • 18 - Cuir et imitations du cuir
  • 20 - Meubles et produits décoratifs
  • 21 - Ustensiles, récipients, matériaux pour le ménage; verre; porcelaine; faience
  • 25 - Vêtements; chaussures; chapellerie
  • 26 - Articles de fantaisie; mercerie; fleurs artificielles, cheveux postiches
  • 34 - Tabac; articles pour fumeurs
  • 35 - Publicité; Affaires commerciales
  • 38 - Services de télécommunications
  • 41 - Éducation, divertissements, activités sportives et culturelles
  • 42 - Services scientifiques, technologiques et industriels, recherche et conception
  • 43 - Services de restauration (alimentation); hébergement temporaire
  • 44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.

Produits et services

Recorded content; Computer databases; Media content; Computer software; Games software; Application software; Communication and networking software; Data and file management and database software; Media and publishing software; Office and business applications; Artificial intelligence and machine learning software; Software for monitoring, controlling and running physical world operations; System and system support software, and firmware; Firmware and device drivers; Operating systems; Utility, security and cryptography software; Virtual and augmented reality software; Web application and server software; Content management software; E-commerce and e-payment software; Information technology and audio-visual, multimedia and photographic devices; Communications equipment; Computer networking and data communications equipment; Point-to-point communications equipment; Broadcasting equipment; Antennas and aerials as communications apparatus; Data storage devices and media; Replicating apparatus; Photocopiers; Image scanners; Printers; Data processing equipment and accessories (electrical and mechanical); Calculators; Ticket dispensers; Payment terminals, money dispensing and sorting devices; Coin-operated mechanisms; Peripherals adapted for use with computers and other smart devices; Computers and computer hardware; Computer components and parts; Audio/visual and photographic devices; Audio devices and radio receivers; Display devices, television receivers and film and video devices; Image capturing and developing devices; Signal cables for IT, AV and telecommunication; Magnets, magnetizers and demagnetizers; Scientific and laboratory devices for treatment using electricity; Apparatus, instruments and cables for electricity; Apparatus and instruments for accumulating and storing electricity; Apparatus and instruments for controlling electricity; Photovoltaic apparatus for generating electricity; Electric and electronic components; Cables and wires; Electrical circuits and circuit boards; Antennas and aerials as components; Optical devices, enhancers and correctors; Optical enhancers; Lasers; Glasses, sunglasses and contact lenses; Corrective eyewear; Sunglasses; Safety, security, protection and signalling devices; Alarms and warning equipment; Access control devices; Signalling apparatus; Protective and safety equipment; Head protection; Eye protection; Diving equipment; Navigation, guidance, tracking, targeting and map making devices; Measuring, detecting and monitoring instruments, indicators and controllers; Monitoring instruments; Sensors and detectors; Testing and quality control devices; Measuring, counting, alignment and calibrating instruments; Data loggers and recorders; Weight measuring instruments; Distance and dimension measuring instruments; Speed measuring instruments; Temperature measuring instruments; Electricity measuring instruments; Controllers (regulators); Scientific research and laboratory apparatus, educational apparatus and simulators. Agates; Jet, unwrought or semi-wrought; Amulets [jewellery, jewelry (Am.)]; Anchors [clock- and watchmaking]; Rings [jewellery, jewelry (Am.)]; Spun silver [silver wire]; Silver, unwrought or beaten; Barrels [clock- and watchmaking]; Pendulums [clock- and watchmaking]; Bracelets [jewellery, jewelry (Am.)]; Watchstraps; Busts of precious metal; Watch cases; Clock cases; Watch chains; Chains [jewelry]; Jewelry findings; Jewellery charms; Jewel cases; Necklaces [jewellery]; Chronographs [watches]; Chronoscopes; Stopwatches; Chronoscopes; Diamonds; Tie bars; Figurines of precious metal; Gold thread [jewellery]; Threads of precious metal [jewellery]; Silver thread [jewellery]; Cuff links; Copper tokens; Jewels; Ivory jewelry; Cloisonné jewellery; Jewellery of yellow amber; Badges of precious metal; Iridium; Clock hands; Alloys of precious metal; Ingots of precious metals; Movements for clocks and watches; Medals; Lockets [jewellery]; Precious metals, unwrought or semi-wrought; Watch springs; Coins; Works of art of precious metal; Olivine [gems]; Earrings; Ornaments [jewellery, jewelry (Am.)]; Ornaments of jet; Shoe jewellery; Hat jewellery; Gold, unwrought or beaten; Floor clocks; Atomic clocks; Wristwatches; Watches; Control clocks [master clocks]; Clocks and watches, electric; Osmium; Palladium; Pearls made of ambroid [pressed amber]; Pearls [jewellery]; Beads for making jewelry; Semi-precious stones; Precious stones; Platinum [metal]; Key rings [split rings with trinket or decorative fob]; Jewelry boxes; Clock dials; Sundials; Rhodium; Clockworks; Ruthenium; Boxes of precious metal; Housings for clocks and watches; Jewel cases; Cases for watches [presentation]; Tie pins; Pins being jewelry; Ornamental pins; Brooches [jewellery]; Spinel [precious stones]; Statues of precious metal; Paste jewellery [costume jewelry (Am.)]; Time instruments; Alarm clocks; Watch crystals; Rosaries. Etchings; Aquarelles; Pastes and other adhesives for stationery or household purposes; Franking machines for office use; Franking machines for office use; Scrapbooks; Almanacs; Cigar bands; Hand labelling appliances; Bookbinding apparatus and machines [office equipment]; Vignetting apparatus; Mounting photographs (Apparatus for -); Document laminators for office use; Hand-rests for painters; Modelling clay; Stationery; Bookbinding material; Office requisites; Paper towels; Drawing sets; Stencil cases; Cases for stamps [seals]; Writing cases [stationery]; Atlases; Stickers [stationery]; Ink sticks; Chart pointers, non-electronic; Bibs of paper; Adhesive bands for stationery or household purposes; Gummed tape [stationery]; Table linen of paper; Tickets; Musical greeting cards; Notelets; Pads [stationery]; Sketch pads; Spools for inking ribbons; Binding strips [bookbinding]; Architectural models; Wristbands for the retention of writing instruments; Etching needles; Tracing needles for drawing purposes; Envelopes [stationery]; Inkwells; Tracing patterns; Calendars; Writing board erasers; Song books; Hat boxes of cardboard; Printers' type; Paper; Carbon paper; Copying paper; Silver paper; Wrapping paper; Writing paper; Tracing paper; Wood pulp paper; Filter paper; Hygienic paper; Luminous paper; Waxed paper; Paper for recording machines; Drawer liners of paper, perfumed or not; Electrocardiograph paper; Radiograms (Paper for -); Parchment paper; Xuan paper for Chinese painting and calligraphy; Patterns for making clothes; Patterns for dressmaking; Papier mâché; Cards; Geographical maps; Desk pads; Folders for papers; Signboards of paper or cardboard; Placards of paper or cardboard; Posters; Postcards; Paperboard; Wood pulp board [stationery]; Perforated cards for Jacquard looms; Catalogues; Tags for index cards; Painters' easels; Place mats of paper; Sealing wax; Numbers [type]; Rollers for typewriters; Newsletters; Files [office requisites]; Electrotypes; Printing blocks; Pen clips; Stationery (Cabinets for -) [office requisites]; Starch paste [adhesive] for stationery or household purposes; Pastes and other adhesives for stationery or household purposes; Manifolds [stationery]; Compasses for drawing; Composing sticks; Wrappers [stationery]; Covers of paper for flower pots; Chromos; Rub down transfers; Diagrams; Drawings; Dispensers (Adhesive tape -) [office requisites]; Finger-stalls [office requisites]; Duplicators; Elastic bands for offices; Labels of paper or cardboard; Marker pens; Paper tissues; Printers' blankets, not of textile; Page holders; Paperweights; Staples for offices; Figurines [statuettes] of papier mâché; Cords for bookbinding; Filters (Paper coffee -); Paper bows; Bubble packs (Plastic -) for wrapping or packaging; Absorbent sheets of paper or plastic for foodstuff packaging; Paper sheets [stationery]; Sheets of reclaimed cellulose for wrapping; Viscose sheets for wrapping; Humidity control sheets of paper or plastic for foodstuff packaging; Drawing materials; Writing materials; School supplies [stationery]; Photographs [printed]; Photo-engravings; Stamps; Comic books; Punches [office requisites]; Flags of paper; Paper clasps; Marking chalk; Tailors' chalk; Writing chalk; Chalk for lithography; Newspapers; Pastes and other adhesives for stationery or household purposes; Pastes and other adhesives for stationery or household purposes; Rubber erasers; Paper-clips; Bottle wrappers of paper or cardboard; Pictures; Ink; Indian inks; Correcting ink [heliography]; Bottle envelopes of paper or cardboard; Isinglass for stationery or household purposes; Engraving plates; Address plates for addressing machines; Blackboards; Writing slates; Printed matter; Steel letters; Letters [type]; Booklets; Books; Printers' reglets; Correcting fluids [office requisites]; Lithographs; Typewriters; Envelope sealing machines, for offices; Stapling presses [office requisites]; Sealing machines for offices; Addressing machines; Pencil sharpening machines, electric or non-electric; Manuals [handbooks]; Globes; Stencils [stationery]; Stencil plates; Erasing shields; Teaching materials [except apparatus]; Packaging material made of starches; Modelling materials; Filter materials of paper; Sealing compounds for stationery purposes; Plastics for modelling; Pencils; Charcoal pencils; Slate pencils; Stencils; Pencil leads; Handwriting specimens for copying; Embroidery designs [patterns]; Forms, printed; Adhesive tapes for stationery or household purposes; Self-adhesive tapes for stationery or household purposes; Correcting tapes [office requisites]; Paper ribbons; Inking ribbons for computer printers; Ink ribbons; Typewriter ribbons; Pen wipers; Numbering apparatus; Engravings; Lithographic works of art; Oleographs; Pamphlets; Printed timetables; Sealing wafers; Pantographs [drawing instruments]; Announcement cards [stationery]; Modelling paste; Pastel crayons; Plastic sheets for packaging; Plastic cling film, extensible, for palletization; Pens [office requisites]; Nibs; Nibs of gold; Paint brushes; Writing brushes; Paint brushes; Steel pens; Office perforators; Periodicals; Graining combs; Blueprints; Watercolor saucers (Artists' -); Cream containers of paper; Folders [stationery]; Lithographic stones; Inkstones; Money holders; Paintings [pictures], framed or unframed; Advertisement boards of paper or cardboard; Pencil holders; Pencil lead holders; Penholders; Checkbook covers; Document holders [stationery]; Chalk holders; Passport covers; Pen boxes; Credit card imprinters, non-electric; Erasing products; Prospectuses; Printed publications; Printed publications; Push pins; Writing or drawing books; Square rulers; Display binders; Document files [stationery]; Graphic representations; Scrapers [erasers] for offices; Bookends; Ledgers [books]; Indexes; T-squares for drawing; Drafting rulers; Book binders; Graphic reproductions; Portraits; Magazines [periodicals]; House painters' rollers; Bags [envelopes, pouches] of paper or plastics, for packaging; Conical paper bags; Bags for microwave cooking; Garbage bags of paper or of plastics; Facial tissues of paper; Boxes of cardboard or paper; Paint boxes; File cards; Bookmarkers; Writing cases [sets]; Printing sets, portable [office requisites]; Place mats of paper; Biological samples for use in microscopy [teaching materials]; Histological sections for teaching purposes; Balls for ball-point pens; Seals [stamps]; Shields [paper seals]; Stands for pens and pencils; Mats for beer glasses; Coasters of paper; Squares for drawing; Modelling clays (Moulds for -) [artists' materials]; Steatite [tailor's chalk]; Fountain pens; Fabrics for bookbinding; Paper tapes and cards for the recordal of computer programmes; Drawing instruments; Writing instruments; French curves; Photograph stands; Stamp stands; Holders for stamps [seals]; Notebooks; Paper cutters [office requisites]; Blotting paper; Stamp pads; Ink pads; Typewriter keys; Calculating tables; Drawing boards; Prints [engravings]; Clipboards; Palettes for painters; Tracing cloth; Cloth for bookbinding; Composing frames [printing]; Inking sheets for document reproducing machines; Inking sheets for duplicators; Gummed cloth for stationery purposes; Canvas for painting; Pencil sharpeners, electric or non-electric; Trading cards, other than for games; Stamps [seals]; Address stamps; Sealing stamps; Drawing pens; Tablecloths of paper; Table napkins of paper; Tissues of paper for removing make-up; Transparencies [stationery]; Paper shredders for office use; Cardboard tubes; Moisteners for gummed surfaces [office requisites]; Moisteners [office requisites]; Galley racks [printing]; Paint trays; Trays for sorting and counting money; Flyers; Desk trays; Hectographs; Modelling wax, not for dental purposes; Mimeograph apparatus and machines. Umbrella rings; Saddle trees; Saddlery; Key cases; Fastenings for saddles; Leather shoulder belts; Animal harnesses; Alpenstocks; Walking sticks; Umbrella sticks; Vanity cases, not fitted; Trunks [luggage]; Traveling trunks; Casual bags; Slings for carrying infants; Sport bags; Chain mesh purses; Tool bags of leather, empty; Purses; Handbags; Travelling sets [leatherware]; Horse bridles; Bridoons; Straps for soldiers' equipment; Kid; Bags (Game -) [hunting accessories]; Briefbags; Satchels; Leatherboard; Cases of leather or leatherboard; Head-stalls; Straps (Leather -); Collars for animals; Horse collars; Horse blankets; Laces (Leather -); Leather straps; Straps of leather [saddlery]; Harness straps; Straps for skates; Leather, unworked or semi-worked; Horseshoes; Leather thread; Moleskin [imitation of leather]; Umbrella covers; Whips; Knee-pads for horses; Casings, of leather, for springs; Covers for horse saddles; Pads for horse saddles; Trimmings of leather for furniture; Harness fittings; Leather leashes; Imitation leather; Walking cane handles; Umbrella handles; Suitcase handles; Pouch baby carriers; Pouch baby carriers; Cat o' nine tails; Chin straps, of leather; Bits for animals [harness]; Muzzles; Parasols; Blinkers [harness]; Umbrellas; Animal skins, hides; Cattle skins; Curried skins; Skins of chamois, other than for cleaning purposes; Fur; Skin (Goldbeaters' -); Rubber parts for stirrups; Credit card cases [wallets]; Card cases [notecases]; Music cases; Wallets; Reins; Net bags for shopping; Furniture coverings of leather; Haversacks; Feed bags for animals; Bags [envelopes, pouches] of leather, for packaging; Bags for campers; Beach bags; Sport bags; Travelling bags; Bags for climbers; Boxes of leather or leatherboard; Boxes of vulcanised fibre; Hat boxes of leather; Butts [parts of hides]; Walking stick seats; Riding saddles; Stirrups; Stirrup leathers; Umbrella or parasol ribs; Frames for umbrellas or parasols; Handbag frames; Traces [harness]; Valises; Attaché cases; Attaché cases; Garment bags for travel; Valves of leather; Backpacks. Bed fittings, not of metal; Furniture fittings, not of metal; Door fittings, not of metal; Beehives; Plate racks; Yellow amber; Curtain rings; Stuffed animals; Head-rests [furniture]; Cupboards; Medicine cabinets; Claws (Animal -); Hand-held flagpoles, not of metal; Coatstands; Ivory, unworked or semi-worked; Winding spools, not of metal, non-mechanical, for flexible hoses; Poles for curtains; Picture rods; Whalebone, unworked or semi-worked; Bamboo; Workbenches; Benches [furniture]; Saw benches [furniture]; Counters [tables]; Coffins; Barrels, not of metal; Ambroid bars; Door knockers, not of metal; Chests, not of metal; Reels of wood for yarn, silk, cord; Non-mechanical reels, not of metal, for flexible hoses; Curtain tie-backs; Casks, not of metal; Identification bracelets, not of metal; Sideboards; Dinner wagons; Bolts, not of metal; Busts of wood, wax, plaster or plastic; Costume stands; Door bells, not of metal, non-electric; Settees; Kennels; Reeds [plaiting materials]; Taps, not of metal, for casks; Bolsters; Non-metal bottle caps; Sealing caps, not of metal; Trolleys [furniture]; Infant walkers; Plastic key cards, not encoded and not magnetic; Placards of wood or plastics; Index cabinets; Chests for toys; Letter boxes, not of metal or masonry; Lockers; Chests of drawers; Trestles [furniture]; Saw horses; Waxcomb for beehives; Barrel hoops, not of metal; Hinges, not of metal; Hampers [baskets] for the transport of items; Baskets, non-metallic; Bottle closures, not of metal; Closures for containers, non-metallic; Plugs, not of metal; Mobiles [decoration]; Shells; Oyster shells; Floating containers, not of metal; Containers, not of metal [storage, transport]; Coral; Animal horns; Stag antlers; Picture frames; Horn, unworked or semi-worked; Corozo; Tea carts; Kennels for household pets; Bassinets; Cushions; Air cushions, not for medical purposes; Pet cushions; Covers for clothing [wardrobe]; Covers (Garment -) [storage]; Nuts, not of metal; Decorations of plastic for foodstuffs; Meat safes; Towel dispensers, fixed, not of metal; Divans; Staves of wood; Display racks; Newspaper display stands; Curtain holders, not of textile material; Baby changing platforms; Baby changing platforms; Honeycombs; Stair rods; Plaster statues; Figurines made of wood; Statuettes of bone; Statuettes made of ivory; Figurines made of gypsum derivatives; Edgings of plastic for furniture; Casks of wood for decanting wine; Crates; Nesting boxes; Hooks, not of metal, for clothes rails; Clothes hooks, not of metal; Curtain hooks; Mooring buoys, non-metallic; Beds for pets; Flower stands; Rattan; Plaited straw, except matting; Clothes hangers and clothes hooks; Pillows; Air pillows, not for medical purposes; Window fittings, not of metal; Coffin fittings, not of metal; Bottle casings of wood; Imitation tortoiseshell; Cask stands, not of metal; Stands for calculating machines; Signboards of wood or plastics; Mirror tiles; Cabinet work; Lecterns; Scratching posts for cats; Beds; Hospital beds; Hydrostatic beds, not for medical purposes; Mother-of-pearl, unworked or semi-worked; Mannequins and tailors' dummies; Door handles, not of metal; Mattresses; Air mattresses, not for medical purposes; Changing mats; Bedding, except linen; Inflatable furniture; Furniture of metal; Office furniture; Furniture; School furniture; Picture frame moldings; Brush mountings; Vice benches [furniture]; Wood ribbon; Straw edgings; Nesting boxes for household pets; House numbers, not of metal, non-luminous; Works of art of wood, wax, plaster or plastic; Wickerwork; Inflatable publicity objects; Wind chimes [decoration]; Mattress (Straw -); Shoulder poles [yokes]; Handling pallets, not of metal; Transport pallets, not of metal; Baskets, non-metallic; Fishing baskets; Keyboards for hanging keys; Furniture partitions of wood; Fireguards; Screens [furniture]; Pegs [pins], not of metal; Poles, not of metal; Table tops; Non-metal dog tags; Loading pallets, not of metal; Tent pegs, not of metal; Flower-pot pedestals; Ambroid plates; Armchairs; Hairdressers' chairs; Knobs, not of metal; Towel stands [furniture]; Hat stands; Reading easels; Umbrella stands; Magazine racks; Bottle racks; Doors for furniture; Pulleys of plastics for blinds; Writing desks; Writing desks; Fodder racks; Gun racks; Playpens; Packaging containers of plastic; Containers, not of metal, for liquid fuel; Mattresses; Furniture shelves; Shelves for storage; Library shelves; Shelves for filing-cabinets [furniture]; Mats, removable, for sinks; Rivets, not of metal; Support rails for curtains; Rollers [casters], not of metal; Bed casters, not of metal; Curtain rollers; Loading gauge rods, not of metal, for railway waggons [wagons]; Latches, not of metal; Racks; Filing cabinets; Ladders of wood or plastics; Boarding stairs, not of metal, mobile, for passengers; Steps [ladders], not of metal; Step stools, not of metal; Boxes of wood or plastic; Writing desks; Writing desks; Sun loungers; Seats; Seats of metal; High chairs for babies; Reservoirs, not of metal nor of masonry; Non-metal cable clips; Locks, other than electric, not of metal; Non-metal door bolts; Locks, not of metal, for vehicles; Stools; Sofas; Stakes, not of metal, for plants or trees; Mirrors (silvered glass); Hand-held mirrors [toilet mirrors]; Meerschaum; Clothes hangers and clothes hooks; Bakers' bread baskets; Statues of wood, wax, plaster or plastic; Fixing plugs, not of metal; Indoor window blinds [shades] [furniture]; Mats for infant playpens; Screw tops, not of metal, for bottles; Corks for bottles; Corks; Numberplates, not of metal; Tortoiseshell; Tables; Shelves for typewriters; Drafting tables; Dressing tables; Tables of metal; Massage tables; Washstands [furniture]; Trolleys for computers [furniture]; Sections of wood for beehives; Embroidery frames; Wood bedsteads; Bamboo curtains; Bead curtains for decoration; Interior textile window blinds; Freestanding partitions [furniture]; Deck chairs; Straw plaits; Chopping blocks [tables]; Troughs, not of metal, for mixing mortar; Birds (Stuffed -); Funerary urns; Water-pipe valves of plastic; Drains [valves] made of plastic; Valves, not of metal, other than parts of machines; Vats, not of metal; Trays, not of metal; Slatted indoor blinds; Fans for personal use, non-electric; Showcases; Glass (Silvered -) [mirrors]; Screws, not of metal; Animal hooves. Drinking troughs; Fly swatters; Indoor aquaria; Shoe trees; Shoe trees; Glove stretchers; Cruets; Glass vials [receptacles]; Rails and rings for towels; Poultry rings; Napkin rings; Rings for birds; Deodorising apparatus for personal use; Polishing apparatus and machines, for household purposes, non-electric; Make-up removing appliances; Noodle machines, hand-operated; Aerosol dispensers, not for medical purposes; Bottle openers, electric and non-electric; Brush goods; Pipettes [wine-tasters]; Bread boards; Washing boards; Cutting boards for the kitchen; Basins [bowls]; Bird baths; Basins [receptacles]; Cocktail stirrers; Chopsticks; Cooking pot sets; Carpet beaters [hand instruments]; Beaters, non-electric; Pouring spouts; Beer mugs; Beverage glassware; Cups of paper or plastic; Tankards; Jars (Glass -) [carboys]; Glass bowls; Tea infusers; Boxes for sweetmeats; Drinking bottles; Isothermic bags; Bottles; Glass flasks [containers]; Insulating flasks; Refrigerating bottles; Pitchers; Butter dishes; Busts of china, terra-cotta or glass; Coffeepots, non-electric; Mugs; Shoe horns; Butter-dish covers; Candlesticks; Candlesticks; Fabrics (Buckets made of woven -); Straws for drinking; Jars; Lazy susans; Cotton waste for cleaning; Wool waste for cleaning; Saucepans; Boot jacks; Corkscrews, electric and non-electric; Furniture dusters; Epergnes; Bread baskets for household purposes; Baskets for household purposes; Waste paper baskets; Closures for pot lids; Shakers; Strainers; Tea strainers; Confectioners' decorating bags [pastry bags]; Aquarium hoods; Covers for dishes; Pot lids; Ironing board covers, shaped; Fruit cups; Cheese-dish covers; Tea cosies; Covers, not of paper, for flower pots; Horns (Drinking -); Plate glass [raw material]; Crystal [glassware]; Cinder sifters for household purposes; Sifters [household utensils]; Mixing spoons [kitchen utensils]; Kettles, non-electric; Abrasive pads for kitchen purposes; Comb cases; Demijohns; Attracting and killing insects (Electric devices for -); Attracting and killing insects (Electric devices for -); Tie presses; Toilet roll dispensers; Soap dispensers; Water apparatus for cleaning teeth and gums; Blenders, non-electric, for household purposes; Earthenware; Hip flasks; Vitreous silica fibers [fibres], not for textile use; Fibreglass, other than for insulation or textile use; Figurines [statuettes] of porcelain, ceramic, earthenware or glass; Fibreglass thread, not for textile use; Floss for dental purposes; Coffee filters, non-electric; Tea strainers; Strainers for household use; Window-boxes; Flasks; Deep fryers, non-electric; Whisks, non-electric, for household purposes; Smoke absorbers for household purposes; Cages for household pets; Buttonhooks; Mess-tins; Portable cool boxes, non-electric; China ornaments; Griddles [cooking utensils]; Kitchen graters; Gardening gloves; Polishing gloves; Gloves for household purposes; Trays of paper, for household purposes; Trays for household purposes; Funnels; Watering cans; Sprinklers; Salad bowls; Signboards of porcelain or glass; Steel wool for cleaning; Glass wool, other than for insulation; Tar-brushes, long handled; Nozzles for watering hose; Dripping pans; Vegetable dishes; Wax-polishing (Apparatus for -), non-electric; Wax-polishing appliances, non-electric, for shoes; Coffee percolators, non-electric; Pepper mills, hand-operated; Coffee grinders, hand-operated; Majolica; Mangers for animals; Cooking pots; Autoclaves, non-electric, for cooking; Feeding troughs; Polishing materials for making shiny, except preparations, paper and stone; Material for brush-making; Rolling pins, domestic; Basting spoons [cooking utensils]; Clothes-pegs; Mosaics of glass, not for building; Mills for household purposes, hand-operated; Toilet cases; Picnic baskets (Fitted -), including dishes; Nest eggs, artificial; Works of art, of porcelain, terra-cotta or glass; Opaline glass; Cauldrons; Scoops for household purposes; Tart scoops; Cleaning rags; Dustbins; Hair for brushes; Polishing leather; Skins of chamois for cleaning; Shaving brushes; Hot pots, not electrically heated; Pepper pots; Combs; Comb (electric); Combs for animals; Combs for the hair (Large-toothed -); Plates to prevent milk boiling over; Plates; Serving platters; Paper plates; Disposable table plates; Saucers; Candle rings; Feather brooms; Powder puffs; Porcelain ware; Knife rests for the table; Menu card holders; Stands for shaving brushes; Soap dishes; Sponge holders; Toothpick holders; Table napkin holders; Cosmetic powder compacts; Toilet roll holders; Egg cups; Fruit presses, non-electric, for household purposes; Ceramics for household purposes; Crumb trays; Pastry cutters; Heat-insulated containers; Heat-insulated containers for beverages; Drinking vessels; Lunch boxes; Bread bins; Containers for household or kitchen use; Kitchen containers; Thermally insulated containers for food; Portable cool boxes, non-electric; Salt shakers; Non-metal coin banks; Heaters for feeding bottles, non-electric; Boxes of glass; Cookie jars; Tea caddies; Boxes for dispensing paper towels; Soap boxes; Brooms; Mops; Carpet sweepers; Buckets; Ice buckets; Coffee services [tableware]; Liqueur sets; Tea services [tableware]; Spice sets; Services [dishes]; Oil cruets; Sieves [household utensils]; Bristles (Animal -) [brushware]; Siphon bottles for carbonated water; Silica (Fused -) [semi-worked product], other than for building; Vessels of metal for making ices and iced drinks; Coasters, not of paper or textile; Trivets [table utensils]; Cosmetic spatulas; Spatulas for kitchen use; Brushes; Brushes (Electric -), except parts of machines; Boot brushes; Horse brushes; Dishwashing brushes; Brushes for cleaning tanks and containers; Eyebrow brushes; Toilet brushes; Lamp-glass brushes; Toothbrushes; Toothbrushes, electric; Nail brushes; Scrubbing brushes; Candle extinguishers; Pins of metal (Cooking -); Dusting apparatus, non-electric; Presses (Garlic -) [kitchen utensils]; Sprinklers for watering flowers and plants; Toilet sponges; Sponges for household purposes; Abrasive sponges for scrubbing the skin; Cake moulds; Waffle irons, non-electric; Ice cube molds; Cookery molds [moulds]; Moulds [kitchen utensils]; Statues of porcelain, ceramic, earthenware or glass; Figurines [statuettes] of porcelain, ceramic, earthenware or glass; Laundry drying racks; Trouser presses; Cleaning tow; Currycombs; Mop wringers; Cloth for washing floors; Dusting cloths; Sprinkling devices; Cleaning instruments, hand-operated; Plungers for clearing blocked drains; Toothpicks; Gridiron supports; Flat-iron stands; Holders for flowers and plants [flower arranging]; Cookie [biscuit] cutters; Metal scouring pads; Pads for cleaning; Baking mats; Glass stoppers; Ironing boards; Cups; Saucepans (Earthenware -); Teapots; Stretchers for clothing; Terrariums (Indoor -) [plant cultivation]; Terrariums (Indoor -) [vivariums]; Watering can sprinklers; Washtubs; Washtubs; Insect traps; Fly catchers [traps or whisks]; Rat traps; Mouse traps; Kitchen grinders, non-electric; Birdcages; Urns; Cosmetic utensils; Cooking utensils, non-electric; Kitchen utensils; Household utensils; Toilet utensils; Perfume vaporizers; Litter boxes for pets; Baby baths, portable; Tableware, other than knives, forks and spoons; Pottery; Pots; Vases; Flower pots; Chamber pots; Perfume burners; Glue-pots; Cabarets [trays]; Opal glass; Glasses [receptacles]; Painted glassware; Glass incorporating fine electrical conductors; Glass, unworked or semi-worked, except building glass; Powdered glass for decoration; Unfinished glass for vehicle windows; Enamelled glass; Sugar bowls; Soup bowls; Broom handles, not of metal. Rainproof clothing; Clothing of imitations of leather; Leather clothing; Motorists' clothing; Cyclists' clothing; Clothing for gymnastics; Gowns; Suits; Pinafore dresses; Bathrobes; Non-slipping devices for footwear; Clothing; Bandanas [neckerchiefs]; Bibs, not of paper; Bonnets; Berets; Underwear; Sweat-absorbent underwear; Boas [necklets]; Teddies [underclothing]; Suspenders; Corsets; Goloshes; Skull caps; Footwear; Training shoes; Stockings; Sweat-absorbent stockings; Socks; Breeches; Swimming trunks; Shirts; Short-sleeve shirts; Bodices [lingerie]; Sports singlets; Hats; Top hats; Hats (Paper -) [clothing]; Coats; Hoods [clothing]; Frames (Hat -) [skeletons]; Stuff jackets [clothing]; Chasubles; Belts [clothing]; Belts (Money -) [clothing]; Tights; Shoulder wraps; Detachable collars; Camisoles; Headgear; Layettes [clothing]; Corselets; Swimming costumes; Masquerade costumes; Beachwear; Neckties; Ascots; Bathing caps; Shower caps; Knickers; Headbands [clothing]; Pocket squares; Fittings of metal for footwear; Linings (Ready-made -) [parts of clothing]; Scarves; Gabardines [clothing]; Boot uppers; Gaiters; Jackets [clothing]; Garters; Fishing vests; Stuff jackets [clothing]; Fishermen's jackets; Skirts; Aprons [clothing]; Pinafore dresses; Aprons [clothing]; Girdles; Mittens; Gloves [clothing]; Ski gloves; Welts for footwear; Ready-to-wear clothing; Paper clothing; Knitwear [clothing]; Jumpers; Leg warmers; Leggings [trousers]; Liveries; Jumpers; Hosiery; Sweaters; Sweaters; Muffs [clothing]; Maniples; Pelerines; Mantillas; Sleep masks; Skorts; Miters [hats]; Boxer shorts; Babies' pants [clothing]; Briefs; Wetsuits for water-skiing; Waistcoats; Trousers; Mules; Ear muffs [clothing]; Parkas; Pelisses; Furs [clothing]; Shirt yokes; Pyjamas; Cuffs; Ponchos; Sweaters; Tips for footwear; Stocking suspenders; Sock suspenders; Brassieres; Heelpieces for stockings; Sandals; Bath sandals; Saris; Sarongs; Leg warmers; Footmuffs, not electrically heated; Shoes; Espadrilles; Bath slippers; Gymnastic shoes; Beach shoes; Football boots; Training shoes; Ski boots; Shawls; Sashes for wear; Wimples; Insoles; Topcoats; Outerclothing; Dress shields; Knee-high stockings; Petticoats; Slips [underclothing]; Shirt fronts; Half-boots; Lace boots; Boots; Fur stoles; Footwear soles; Studs for football boots; Heels; Heelpieces for footwear; Pockets for clothing; Tee-shirts; Togas; Footwear uppers; Turbans; Combinations [clothing]; Uniforms; Veils [clothing]; Robes; Cap peaks; Sun visors [headwear]; Visors (headgear); Wooden shoes. Needles; Shoemakers' needles; Sewing needles; Needles for wool combing machines; Darning needles; Binding needles; Saddlers' needles; Appliqués [haberdashery]; Decorative articles for the hair; Haberdashery, except thread; Needle cases; False moustaches; False beards; Curlpapers; Hair curlers; Darning lasts; Edgings for clothing; Buttons; Stud buttons; Brassards; Armband for holding sleeves; Brassards; False hair; Human hair; Needle cases; Bows for the hair; Zippers; Zippers for bags; Dress fastenings; Numerals for marking linen; Numerals for marking linen; Chenille [passementerie]; Rosettes [haberdashery]; Cords for clothing; Cords for trimming; Woollen laces; Braids; Artificial flower wreaths; Hair colouring caps; Needle cushions; Pin cushions; Badges for wear, not of precious metal; Badges [buttons] (Ornamental novelty -); Sewing thimbles; Hair extensions; Hook and pile fastening tapes; Hair bands; Belt clasps; Bobby pins; Fastenings for suspenders; Knitting needles; Festoons [embroidery]; Buckles [clothing accessories]; Shoe fasteners; Dress body fasteners; Shoe buckles; False hems; Top-knots [pompoms]; Artificial flowers; Curling pins; Fringes; Embroidery; Artificial fruit; Frills for clothing; Lace for edgings; Hooks [haberdashery]; Hooks for corsets; Shoe hooks; Artificial garlands; Bodkins; Numerals for marking linen; Orsedew [trimmings for clothing]; Trouser clips for cyclists; Tassels [haberdashery]; Elastic ribbons; Ribbons [haberdashery]; Prize ribbons; Tapes for curtain headings; Shoe eyelets; Eyelets for clothing; Shoe trimmings; Hat trimmings; Spangles for clothing; Wigs; Lace trimmings; Birds' feathers [clothing accessories]; Beads, other than for making jewelry; Competitors' numbers; Heat adhesive patches for repairing textile articles; Heat adhesive patches for decoration of textile articles; Artificial plants; Feathers [clothing accessories]; Ostrich feathers [clothing accessories]; Hair nets; Silver embroidery; Gold embroidery; Bobbins for retaining embroidery floss or wool [not parts of machines]; Mica spangles; Sewing boxes; Picot [lace]; Trimmings for clothing; Shoulder pads for clothing; Brooches [clothing accessories]; Pins, other than jewellery [jewelry (Am.)]; Hair pins; Shuttles for making fishing nets; Whalebones for corsets; Collar supports; Shoe laces; Toupees; Tresses of hair; Frills [lacework]; Crochet hooks; Rug hooks; Skirt flounces. Lighters for smokers; Pocket machines for rolling cigarettes; Cigarette holders; Cigar holders; Tobacco pouches; Absorbent paper for tobacco pipes; Cigarette paper; Cigarillos; Cigar cases; Herbs for smoking; Matches; Cigarette filters; Pipe cleaners for tobacco pipes; Firestones; Pipes; Ashtrays; Match holders; Tips of yellow amber for cigar and cigarette holders; Tips of yellow amber for cigar and cigarette holders; Cigarette tips; Mouthpieces for cigarette holders; Books of cigarette papers; Pipe racks for tobacco pipes; Matchboxes; Cigarette cases; Humidors; Gas containers for cigar lighters; Cigarettes; Cigarettes containing tobacco substitutes, not for medical purposes; Electronic cigarettes; Cigars; Spittoons for tobacco users; Snuff boxes; Tobacco; Chewing tobacco; Snuff; Cigar cutters; Tobacco jars. Bill-posting; Rental of vending machines; Rental of advertising time on communication media; Commercial information agencies; Advertising agencies; Import-export agency services; Updating of advertising material; Updating and maintenance of data in computer databases; Shop window dressing; Commercial administration of the licensing of the goods and services of others; Cost price analysis; Commercial or industrial management assistance; Assistance in management of business activities; Personnel management consulting; Business management consulting; Professional business consulting; Accounting; Dissemination of advertisements; Demonstration of goods; Business management of performing artists; Distribution of samples for publicity purposes; Direct mail advertising; Compilation of statistics; Invoicing; Provision of commercial and business contact information; Business management of hotels; Business management of sports people; Business management for freelance service providers; Computerized file management; Providing business information via a web site; Business information; Consumers (Commercial information and advice for -) [consumer advice shop]; Business investigation; Layout services for advertising purposes; Rental of advertising space; Marketing services; Negotiation and conclusion of commercial transactions for third parties; Rental of photocopying machines; Office machines and equipment rental; Publicity material rental; Rental of sales stands; Organization of exhibitions for commercial or advertising purposes; Organisation of trade fairs for commercial or advertising purposes; Fashion shows for promotional purposes (Organization of -); Web site traffic optimization; Search engine optimisation; Efficiency experts; Payroll preparation; Presentation of goods on communication media, for retail purposes; Economic forecasting; Production of advertising films; Sales promotion for others; Publication of publicity texts; Advertising; Advertising, including on-line advertising on a computer network; Advertising by mail order; Radio advertising; Television advertising; Compilation of information into computer databases; Business inquiries; Personnel recruitment; Writing of publicity texts; Public relations services; Sponsorship search; Data search in computer files for others; Conducting of marketing studies; Marketing studies; Business research; Document reproduction; Personnel selection using psychological testing; Arranging newspaper subscriptions for others; Arranging subscriptions to telecommunication services for others; Procurement services for third parties (acquisition of goods and services for other companies); Price comparison services; Consultancy regarding business organisation and business economics; Advisory services for business management; Business organisation consulting; Typing services; Photocopying services; Business project management services for construction projects; Modelling for advertising or sales promotion; Commercial intermediation services; News clipping services; Relocation services for businesses; Telephone answering for unavailable subscribers; Secretarial services; Shorthand; Outsourcing services [business assistance]; Telemarketing services; Retail or wholesale services for pharmaceutical, veterinary and sanitary preparations and medical supplies; Pay per click advertising; Opinion polling; Tax preparation; Drawing up statements of account; Transcription of communications [office functions]; Administrative processing of purchase orders; Word processing; Employment agencies; Business appraisal; Auctioneering services; Business auditing. News agencies; Providing telecommunications connections to a global computer network; Communications by fibre optic networks; Radio communications; Communications by telephone; Communication by telegram; Communications by computer terminals; Television broadcasting; Providing access to databases; Providing user access to global computer networks; Providing telecommunication channels for teleshopping services; Providing internet chatrooms; Provision of on-line forums; Information about telecommunication; Electronic messaging; Rental of access time to global computer networks; Rental of telecommunication equipment; Rental of message sending apparatus; Rental of facsimile apparatus; Rental of modems; Rental of telephones; Communications by cellular phones; Paging services [radio, telephone or other means of electronic communication]; Wireless broadcasting; Telecommunications routing and junction services; Electronic bulletin board services [telecommunications services]; Voice mail services; Teleconferencing services; Providing video conferencing services; Telephone services; Telegraph services; Telex services; Cable television broadcasting; Transmission of greeting cards online; Transmission of digital files; Message sending; Computer-aided transmission of messages and images; Facsimile transmission; Telegram transmission; Transmission of greeting cards online; Satellite transmission. Academies [education]; Animal training; Rental of movie projectors and accessories; Rental of show scenery; Rental of stage scenery; Rental of tennis courts; Rental of motion pictures; Rental of sound recordings; Coaching [training]; Sport camp services; Casino facilities [gambling] (Providing -); Circuses; Boarding schools; Music composition services; Boarding schools; Conducting fitness classes; Timing of sports events; Entertainment; Radio entertainment; Television entertainment; Dubbing; Education; Religious education; Educational examination; Practical training [demonstration]; Golf facilities (Providing -); Photography; Recreation information; Education information; Entertainment information; Gymnastic instruction; Correspondence courses; Sign language interpretation; Tuition; Layout services, other than for advertising purposes; Night club services [entertainment]; Night club services [entertainment]; Providing karaoke services; Providing sports facilities; Microfilming; Production of television and radio programs; Videotape editing; Music-halls; Rental of audio equipment; Rental of lighting apparatus for theatrical sets or television studios; Rental of radio and television sets; Games equipment rental; Rental of sports equipment, except vehicles; Rental of skin diving equipment; Rental of toys; Rental of sports grounds; Rental of video recorders; Rental of stadium facilities; Rental of video cameras; Rental of videotapes; Organization of balls; Organisation of sports competitions; Arranging of beauty contests; Organisation of competitions [education or entertainment]; Organization of exhibitions for cultural or educational purposes; Operating of lotteries; Organization of fashion shows for entertainment purposes; Organization of shows [impresario services]; Arranging and conducting of congresses; Arranging and conducting of colloquiums; Arranging and conducting of symposiums; Arranging and conducting of conferences; Arranging and conducting of seminars; Arranging and conducting of concerts; Workshops (Arranging and conducting of -) [training]; Vocational guidance [education or training advice]; Amusement park services; Planning (Party -) [entertainment]; Booking of seats for shows; Rental of books; Film production, other than advertising films; Film production, other than advertising films; Production of music; Production of shows; Cinema presentations; Publication of books; Publication of texts, other than publicity texts; Electronic text publishing services; On-line publication of electronic books and journals (non-downloadable); Publication of printed matter in electronic form; Publication of periodicals and books in electronic form; On-line publication of electronic books and journals (non-downloadable); Electronic online publication of periodicals and books; Publishing by electronic means; Performances (Presentation of live -); Theater productions; Scriptwriting services; Writing of texts, other than publicity texts; Videotaping; Photographic reporting; Vocational retraining; Nursery schools; Modelling for artists; Entertainer services; Mobile library services; Ticket agency services [entertainment]; Calligraphy services; Camp services (Holiday -) [entertainment]; Health club services [health and fitness training]; Club services [entertainment or education]; News reporters services; Disc jockey services; Discotheque services; Recreation facilities (Providing -); Zoological garden services; Online games (originating from a computer network); Language interpreter services; Museum facilities (Providing -) [presentation, exhibitions]; Orchestra services; Personal trainer services [fitness training]; Amusement arcade services; Recording studios; Translation and interpretation; Educational services provided by schools; Subtitling; Movie studios; Tutoring. Updating of computer software; Land surveying; Chemical analysis; Handwriting analysis [graphology]; Water analysis; Computer system analysis; Architecture; Electronic data storage; Authenticating works of art; Cloud computing; Material testing; Architectural consultation; Consultancy in the field of energy-saving; Computer software consultancy; Consultancy in the design and development of computer hardware; Web site design consultancy; Oil-well testing; Quality control; Testing [inspection] of vehicles for roadworthiness; Conversion of computer programs and data, other than physical conversion; Conversion of data or documents from physical to electronic media; Creating and maintaining web sites for others; Design of interior decor; Digitization of documents [scanning]; Industrial design; Duplicating computer programs; Computer software design; Oil-field surveys; Underwater exploration; Provision of scientific information, advice and consultancy in relation to carbon offsetting; Providing information on computer technology and programming via a web site; Providing search engines for the internet; Engineering services; Cloud seeding; Installation of software; Rental of software; Maintenance of software; Monitoring of computer systems by remote access; Computer rental; Rental of web servers; Hosting computer sites; Geological surveys; Surveying; Urban planning; Computer system design; Construction drafting; Computer programming; Geological prospecting; Clinical trials; Textile testing; Recovery of computer data; Oil prospecting; Research and development for others; Biological research; Geological research; Bacteriological research; Chemical research; Cosmetic research; Physics [research]; Physics research; Research in the field of environmental protection; Mechanical research; Scientific research; Technical research relating to computers; Preparation of reports relating to technical research; Off-site data backup; Server hosting; Analysis for oil-field exploitation; Meteorological information; Analysis for oil-field exploitation; Mapping services; Chemist services; Information technology [IT] consultancy; Graphic art design; Packaging design; Laboratory (Scientific -) services; Computer virus protection services; Software as a service [SaaS]; Dress designing; Styling [industrial design]; Conducting technical project studies; Calibration [measuring]; Quality evaluation of standing timber; Evaluation of wool (Quality -); Quality evaluation of standing timber; Energy auditing. Accommodation bureaux [hotels, boarding houses]; Day-nurseries [crèches]; Café services; Café services; Retirement homes; Tourist homes; Providing campground facilities; Rental of temporary accommodation; Canteens; Rental of lighting apparatus; Rental of cooking apparatus; Rental of portable buildings; Rental of drinking water dispensers; Rental of meeting rooms; Rental of chairs, tables, table linen, glassware; Rental of tents; Pet boarding services; Boarding houses; Hotel reservations; Temporary accommodation reservations; Boarding house bookings; Restaurants; Self-service restaurant services; Food sculpting; Hotel services; Bar services; Holiday camp services [lodging]; Catering for the provision of food and beverages; Motels; Snack-bars. Farming (animals); Landscape design; Dentistry; Animal healthcare services; Public baths for hygiene purposes; Turkish baths; Nursing home services; Convalescent home services; Chiropractics; Tree surgery; Plastic surgery; Medical clinic services; Floral design; Wreath making; Pharmacy advice; Advisory services relating to health; Depilatory waxing; Rehabilitation of substance abuse patients; Vermin exterminating for agriculture, aquaculture, horticulture and forestry; Weed killing; Physical therapy; Gardening; Hair implantation; Lawn care; Massage; Medical equipment rental; Rental of sanitary installations; Farming equipment rental; Horticulture; Hospices; Tree planting for carbon offsetting purposes; Animal grooming; Beauty salons; Hair salon services; Sanatoriums; Plant nurseries; Opticians' services; Aquaculture services; Aromatherapy services; Health spa services; Blood bank services; Medical clinic services; Preparation of prescriptions by pharmacists; In vitro fertilization services; Landscape gardening; Medical nursing; Artificial insemination services; Speech therapy; Manicuring; Alternative medicine services; Orthodontic services; Midwife services; Psychologist (Services of a -); Sauna services; Solarium services; Telemedicine services; Visagists' services; Medical assistance; Hospitals; Medical services; Therapy services; Aerial and surface spreading of fertilizers and other agricultural chemicals; Animal grooming; Tattooing.

82.

Notch inhibitors for use in the treatment of t-cell acute lymphoblastic leukemia

      
Numéro d'application 16473986
Numéro de brevet 11104657
Statut Délivré - en vigueur
Date de dépôt 2017-12-20
Date de la première publication 2019-11-07
Date d'octroi 2021-08-31
Propriétaire
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
  • UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
  • Botta, Bruno
  • Screpanti, Isabella
  • Tottone, Luca
  • Zhdanoskaya, Nadezda
  • Ingallina, Cinzia
  • Giulimondi, Francesca
  • Quaglio, Deborah
  • Palermo, Rocco
  • Mori, Mattia
  • Ghirga, Francesca

Abrégé

Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).

Classes IPC  ?

  • C07D 309/32 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
  • C07D 309/12 - Atomes d'oxygène uniquement des atomes d'hydrogène et un atome d'oxygène liés directement aux atomes de carbone du cycle, p.ex. éthers du tétrahydropyranne
  • A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
  • C07C 49/248 - Composés non saturés comportant des groupes cétone liés à des atomes de carbone acycliques contenant des groupes hydroxyle contenant des cycles aromatiques à six chaînons avec insaturation autre que celle des cycles aromatiques
  • C07C 49/835 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons contenant des groupes hydroxyle avec insaturation autre que celle d'un cycle aromatique
  • C07C 49/84 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons contenant des groupes éther, des groupes , des groupes ou des groupes
  • A61K 31/121 - Cétones acycliques

83.

A WIRELESS DOPPLER DEVICE FOR BIOMEDICAL APPLICATIONS

      
Numéro d'application IB2019053251
Numéro de publication 2019/207441
Statut Délivré - en vigueur
Date de dépôt 2019-04-19
Date de publication 2019-10-31
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Santanelli Di Pompeo, Fabio
  • Longo, Benedetto

Abrégé

A system for monitoring a flow of an organ and of the body fluid of a patient by Doppler echography, comprising a portable Doppler probe (10) configured to be applied to the body of the patient, wherein the probe comprises a matrix of transducers (11), each transducer being configured to emit in use a respective output ultrasound signal directed towards the body of the patient, receive a respective input ultrasound signal reflected by the body of the patient, and convert the input ultrasound signal into a reading signal, and a main detection unit (20) configured to wirelessly communicate with the portable probe (10), and construct an image of a reflecting biological surface according to the features of the reflected ultrasound waves, identify a body fluid in motion and calculate the speed and direction thereof based on the reading signals provided by the array of transducers (11).

Classes IPC  ?

  • A61B 8/06 - Mesure du débit sanguin
  • A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
  • A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements

84.

IDENTIFICATION OF MUSCULAR miRNAS AS MOLECULAR BIOMARKERS AND CO-ADJUVANT FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY

      
Numéro d'application IB2019052820
Numéro de publication 2019/197954
Statut Délivré - en vigueur
Date de dépôt 2019-04-05
Date de publication 2019-10-17
Propriétaire
  • UNIVERSITÀ CATTOLICA DEL SACRO CUORE (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
  • Tiziano, Francesco Danilo
  • Infante, Paola
  • Di Marcotullio, Lucia
  • Abiusi, Emanuela

Abrégé

The present invention relates to specific inhibitors for human microRNAs, for use in the treatment of spinal muscular atrophy (SMA) and pharmaceutical compositions including them. The present invention further relates to the identification of markers with high sensitivity and specificity for the prognosis of a spinal muscular atrophy (SMA), prognostic methods comprising the use of such markers and prognostic kits for detecting such markers.

Classes IPC  ?

  • C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens

85.

MIRNAS FOR TREATMENT AND IN VITRO DIAGNOSIS OF DRUG RESISTANT TUMORS

      
Numéro d'application IT2019050073
Numéro de publication 2019/198115
Statut Délivré - en vigueur
Date de dépôt 2019-04-10
Date de publication 2019-10-17
Propriétaire
  • ISTITUTI FISIOTERAPICI OSPITALIERI (Italie)
  • ISTITUTO NAZIONALE TUMORI I.R.C.C.S. "FONDAZIONE G. PASCALE" (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Ciliberto, Gennaro
  • Ascierto, Paolo Antonio
  • Fattore, Luigi
  • Botti, Gerardo
  • Mancini, Rita

Abrégé

The present invention concerns miRNAs for in vitro diagnosis of resistance of tumors to BRAF/MEK pathway (also named as MAPK 5 pathway) inhibiting drugs and for treatment of tumors which are treated with said drugs, such as melanoma, by stimulating or inhibiting the expression of down-regulated or up-regulated miRNAs, respectively.

Classes IPC  ?

  • C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

86.

MIRNAS FOR TREATMENT AND IN VITRO DIAGNOSIS OF DRUG RESISTANT TUMORS

      
Numéro de document 03096930
Statut En instance
Date de dépôt 2019-04-10
Date de disponibilité au public 2019-10-17
Propriétaire
  • ISTITUTI FISIOTERAPICI OSPITALIERI (Italie)
  • ISTITUTO NAZIONALE TUMORI I.R.C.C.S. "FONDAZIONE G. PASCALE" (Italie)
  • UNIVERSITA' DEGLI SUTDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Ciliberto, Gennaro
  • Ascierto, Paolo Antonio
  • Fattore, Luigi
  • Botti, Gerardo
  • Mancini, Rita

Abrégé

The present invention concerns miRNAs for in vitro diagnosis of resistance of tumors to BRAF/MEK pathway (also named as MAPK 5 pathway) inhibiting drugs and for treatment of tumors which are treated with said drugs, such as melanoma, by stimulating or inhibiting the expression of down-regulated or up-regulated miRNAs, respectively.

Classes IPC  ?

  • C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

87.

PROCESS FOR THE PRODUCTION OF PROTECTED OXIDIZABLE METAL PARTICLES AND CORRELATED PRODUCTS

      
Numéro d'application IB2019052683
Numéro de publication 2019/193490
Statut Délivré - en vigueur
Date de dépôt 2019-04-02
Date de publication 2019-10-10
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Stoller, Marco
  • Vilardi, Giorgio
  • Di Palma, Luca
  • Verdone, Nicola

Abrégé

The invention refers to a process for the production of oxidizable submicronic particles (nanoparticles) comprising one or more zero-valent metals and incorporated inside a crystallized solid matrix. In particular, the invention refers to a two-step process: (1) synthesis of the metal particles in a solution; (2) crystallization by heterogeneous nucleation of the solute onto the produced particles. The invention also relates to oxidizable metal particles in a crystallized solid matrix, obtained by the process of present invention, and to the uses of these metal particles in the industrial and environmental field.

Classes IPC  ?

  • B82Y 40/00 - Fabrication ou traitement des nanostructures
  • B01J 13/04 - Fabrication de microcapsules ou de microbilles par des procédés physiques, p.ex. séchage, pulvérisation
  • B01J 13/22 - Revêtement
  • B22F 1/00 - Poudres métalliques; Traitement des poudres métalliques, p.ex. en vue de faciliter leur mise en œuvre ou d'améliorer leurs propriétés
  • B22F 9/24 - Fabrication des poudres métalliques ou de leurs suspensions; Appareils ou dispositifs spécialement adaptés à cet effet par un procédé chimique avec réduction de mélanges métalliques à partir de mélanges métalliques liquides, p.ex. de solutions
  • C02F 1/70 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par réduction

88.

COOLING AND ENERGY RECOVERY SYSTEM FOR DEVICES PRODUCING EXCESS HEAT, AND RELATED COOLING METHOD

      
Numéro d'application IB2019052078
Numéro de publication 2019/180553
Statut Délivré - en vigueur
Date de dépôt 2019-03-14
Date de publication 2019-09-26
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s) Sciubba, Enrico

Abrégé

A cooling system (1), and a related method, for devices which produce excess heat, allows an extraction of residual heat from the circulating fluids more effectively with respect to the conventional systems, so that the residual heat could be recovered and exploited, in case even to increase the overall effectiveness of the cooling system, and it comprises: a heat exchanger (2) with two cooling circuits (4, 5) and respective coolants with a negative enthalpy of mixing, means for circulating the refrigerant fluids; means (20) for mixing the coolants for the enthalpy exothermic release in the obtained mixture; and means (23) for extracting heat from said mixture, wherein the outlet temperatures (T2) from the exchanger (2) of the two coolants have a temperature difference lower than 5°C.

Classes IPC  ?

  • F01K 9/00 - Ensembles fonctionnels de machines à vapeur caractérisés par des condenseurs disposés ou modifiés de façon à s'adapter aux machines motrices
  • F01K 25/08 - Ensembles fonctionnels ou machines motrices caractérisés par l'emploi de fluides énergétiques particuliers non prévus ailleurs; Ensembles fonctionnant selon un cycle fermé, non prévus ailleurs utilisant des vapeurs particulières
  • F25B 15/00 - Machines, installations ou systèmes à sorption, à marche continue, p.ex. à absorption

89.

METHOD FOR THE PRODUCTION OF POLYHYDROXYALKANOATES (PHAS) FROM HIGH SOLID CONTENT ORGANIC WASTE

      
Numéro d'application IB2019051844
Numéro de publication 2019/171316
Statut Délivré - en vigueur
Date de dépôt 2019-03-07
Date de publication 2019-09-12
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • UNIVERSITA' CA' FOSCARI (Italie)
  • UNIVERSITA' DEGLI STUDI DI VERONA (Italie)
Inventeur(s)
  • Majone, Mauro
  • Valentino, Francesco
  • Pavan, Paolo
  • Bolzonella, David
  • Micolucci, Federico
  • Gottardo, Marco

Abrégé

A process for the biosynthesis of PHAs from the organic fraction of metropolitan solid waste. The process uses a mixed microbial consortium (MMC) and combines three stages in sequence (Stage I: anaerobic fermentation, Stage II: sequential aerobic fermentation, Stage III: batch aerobic fermentation). The material leaving the fermentation Stage I reactor is initially conveyed through a filter which reduces its content of suspended solids without significantly interfering with the concentration of VFAs and nutrients, such as phosphorus (P) and nitrogen (N), elements that in Stage II, favour the production of the MMC biomass specialized in the synthesis of PHAs, used in the subsequent Stage III. The flow is then divided between the Stage II reactor and a second filter with membrane that eliminates its suspended solid particulate matter and reduces the concentration of P and N, thus favouring the synthesis of PHAs by the microorganisms during Phase III.

Classes IPC  ?

  • C12P 7/62 - Esters d’acides carboxyliques
  • C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse

90.

A CIRCUMCISION DEVICE WITH REMOVABLE PARTS

      
Numéro d'application IB2019051180
Numéro de publication 2019/159087
Statut Délivré - en vigueur
Date de dépôt 2019-02-14
Date de publication 2019-08-22
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s) Al Mansour, Monir

Abrégé

Circumcision device, including a support (10), a rest part (20) comprising a stem (21) and a shearing template (23) arranged fastened on a distal end of the stem (21), which has a concave distal surface (23a) and a side surface (23b) tapered in the proximal direction, and a pair of arms (30, 30') each having a distal end provided with a semi-circular blade (32, 32'). Each arm is rotatable around an axis perpendicular (y, y') to the extension direction of the stem (21), between an open position and a shearing position wherein the semi- circular blades (32, 32') are closed to form a ring perpendicular to the extension axis of the stem (21) and have a cutting edge (33, 33') that engages the side surface (23b) of the shearing template (23). The rest part (20) is removably fastened to the support (10) and the semi-circular blades (32, 32') are removably fastened to their respective levers (30, 30'). Each lever (30, 30') is provided with a guide (31a, 31a') to determine the orientation of the respective semi-circular blade (32, 32').

Classes IPC  ?

91.

METHOD AND SYSTEM FOR THE MEASUREMENT OF HAEMODYNAMIC INDICES

      
Numéro d'application IB2019051196
Numéro de publication 2019/159094
Statut Délivré - en vigueur
Date de dépôt 2019-02-14
Date de publication 2019-08-22
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s) Sterpetti, Antonio Vittorio

Abrégé

Method and relative system for the measurement of haemodynamic indices, said method comprising: acquiring an ultrasound image of at least one segment of an arterial vessel; identifying in said image at least one sample volume; obtaining a time series indicating the blood velocity, or velocity signal (9), in said sample volume and in at least one cardiac cycle; calculating, by means of a processor, a first area (4) equal to the area subtended by the velocity signal (9) between the sample (6) relating to the instant of systole start of said at least one cardiac cycle and the sample (7) of systolic peak; calculating, by means of a processor, a second area (5) subtended by the velocity signal (9) between the sample (7) of systolic peak and the sample (8) relating to the instant of end diastole of said at least one cardiac cycle; calculating the relationship between the second area (5) and the first area (4); selecting a time instant of interest in said at least one cardiac cycle; obtaining the spatial distribution of the velocity in said time instant of interest, or instantaneous distribution of the velocity; identifying the maximum value and the minimum value of the instantaneous distribution of the velocity; and calculating the relationship between the maximum value and the minimum value.

Classes IPC  ?

  • A61B 8/06 - Mesure du débit sanguin
  • A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements

92.

COMPOUNDS FOR USE IN THE TREATMENT OF BRAIN DISEASES

      
Numéro d'application EP2019052800
Numéro de publication 2019/149962
Statut Délivré - en vigueur
Date de dépôt 2019-02-05
Date de publication 2019-08-08
Propriétaire
  • UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
  • Limatola, Cristina
  • D'Alessandro, Giuseppina
  • Di Marcotullio, Lucia
  • Infante, Paola
  • Botta, Bruno
  • Mori, Mattia
  • Ghirga, Francesca
  • Ingallina, Cinzia
  • Berardozzi, Simone

Abrégé

The present invention relates to a compound of formula (1): (1) or an analogue thereof or a pharmaceutically acceptable salt thereof, for use in the treatment of a brain tumor, wherein said compound is administered intranasally and relative pharmaceutical compositions.

Classes IPC  ?

  • A61K 31/366 - Lactones ayant des cycles à six chaînons, p.ex. delta-lactones
  • A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
  • A61P 35/00 - Agents anticancéreux
  • A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
  • A61K 9/16 - Agglomérés; Granulés; Microbilles
  • A61K 9/20 - Pilules, pastilles ou comprimés
  • A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p.ex. PEG, PPG, PEO ou polyglycérol

93.

USE OF A PEPTIDE DERIVED FROM THE HUMAN PROTEIN NTIMP3 IN THE TREATMENT OF DIABETIC NEPHROPATHY

      
Numéro d'application IB2019050482
Numéro de publication 2019/145840
Statut Délivré - en vigueur
Date de dépôt 2019-01-21
Date de publication 2019-08-01
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "TOR VERGATA" (Italie)
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Federici, Massimo
  • Menghini, Rossella
  • Casagrande, Viviana
  • Menini, Stefano

Abrégé

The present invention relates to fusion peptides consisting of the peptide fragment corresponding to the N-terminal domain derived from the human TIMP3 protein, both in native and mutated form, bound by the N-terminal end to a highly selective and efficient carrier peptide for transport in renal proximal tubule cells, the medical use thereof, in particular the use thereof in the treatment of diabetic nephropathy, and the compositions comprising them.

Classes IPC  ?

  • C07K 14/81 - Inhibiteurs de protéase
  • C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion

94.

METHOD AIMED AT PATIENTS WITH MOTOR DISABILITIES FOR SELECTING A COMMAND BY MEANS OF A GRAPHIC INTERFACE, AND CORRESPONDING SYSTEM AND COMPUTER PROGRAM PRODUCT

      
Numéro d'application IB2019050631
Numéro de publication 2019/145907
Statut Délivré - en vigueur
Date de dépôt 2019-01-25
Date de publication 2019-08-01
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • ISTITUTO SUPERIORE DI SANITA' (Italie)
Inventeur(s)
  • Cincotti, Febo
  • Ferriero, Dario Giuseppe
  • Giuseppi, Alessandro
  • Pietrabissa, Antonio
  • Ricciardi Celsi, Lorenzo
  • Poli, Cecilia

Abrégé

v, ωv, ω) of the movement of the cursor. In particular, the estimation procedure (1020) comprises optimisation, for example by means of MPC (Model Predictive Control), of a cost function determined as a function o the estimated target function.

Classes IPC  ?

  • G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
  • G06F 3/0481 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] fondées sur des propriétés spécifiques de l’objet d’interaction affiché ou sur un environnement basé sur les métaphores, p.ex. interaction avec des éléments du bureau telles les fenêtres ou les icônes, ou avec l’aide d’un curseur changeant de comport
  • G06F 3/0484 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] pour la commande de fonctions ou d’opérations spécifiques, p.ex. sélection ou transformation d’un objet, d’une image ou d’un élément de texte affiché, détermination d’une valeur de paramètre ou sélection d’une plage de valeurs

95.

OLEUROPEIN FOR USE IN REDUCING POST-PRANDIAL GLYCAEMIA

      
Numéro d'application IB2018059608
Numéro de publication 2019/111142
Statut Délivré - en vigueur
Date de dépôt 2018-12-04
Date de publication 2019-06-13
Propriétaire UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
  • Violi, Francesco
  • Carnevale, Roberto
  • Nocella, Cristina
  • Pastori, Daniele

Abrégé

Oleuropein for use in reducing post-prandial glycaemia in healthy subjects.

Classes IPC  ?

  • A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p.ex. leucoglucosane, hespéridine, érythromycine, nystatine
  • A61K 36/63 - Oleaceae (famille de l'olive), p.ex. jasmin, lilas ou frêne
  • A61P 3/08 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose
  • A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p.ex. antidiabétiques

96.

COMPOSITION FOR USE IN THE FINISHING, PRESERVATION, RESTORATION OF MANUFACTURES

      
Numéro d'application EP2018082336
Numéro de publication 2019/110325
Statut Délivré - en vigueur
Date de dépôt 2018-11-23
Date de publication 2019-06-13
Propriétaire
  • UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
  • UNIVERSITA' DEGLI STUDI DI PALERMO (Italie)
Inventeur(s)
  • Bianco, Armandodoriano
  • Serafini, Ilaria
  • Cavallaro, Giuseppe
  • Lazzara, Giuseppe

Abrégé

An aqueous composition comprising chitosan and fibroin nanoparticles, with a diameter equal or lower than 140 nm, and an acid agent, with pH equal or lower than 6, and viscosity equal or lower than 3.5 kg × m−1× s−1 measured at 25.0±0.1 °C, kit and method for finishing and/or preservation and/or restoration and/or renovation and/or repairing and/or consolidation of manufactures, in particular ancient manufactures are disclosed.

Classes IPC  ?

  • D06M 15/03 - Polysaccharides ou leurs dérivés
  • D06M 15/15 - Protéines ou leurs dérivés
  • D21H 25/18 - Post-traitement du papier non prévu dans les groupes de vieux papiers tels que des livres ou des documents, p.ex. restauration

97.

ASSEMBLY FOR THE DEPOSITION OF SILICON NANOSTRUCTURES

      
Numéro d'application IB2018057310
Numéro de publication 2019/058325
Statut Délivré - en vigueur
Date de dépôt 2018-09-21
Date de publication 2019-03-28
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s) Palma, Fabrizio

Abrégé

An assembly (1) for the deposition of silicon nanostructures comprising a deposition chamber (2), which is defined by a side wall (3) and by two end walls (4); a microwave generator (5), which is adapted to generate microwaves inside the deposition chamber (2); an electromagnetic termination wall (8), made of a conductor material and reflecting the microwave radiation, which is such as to create a termination for a TE-mode waveguide and is housed inside the deposition chamber (2); and a substrate-carrier support (9), which is made of a dielectric material and on which the substrate is housed on which to perform the growth of silicon nanostructures. The substrate-carrier support (9) is arranged inside the deposition chamber (2) above the termination wall (8).

Classes IPC  ?

  • H01L 21/67 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitement; Appareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants

98.

Process for the production of antimicrobial dental adhesives including graphene and relative product thereof

      
Numéro d'application 16080815
Numéro de brevet 10610461
Statut Délivré - en vigueur
Date de dépôt 2017-03-01
Date de la première publication 2019-03-28
Date d'octroi 2020-04-07
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
  • Sarto, Maria Sabrina
  • Polimeni, Antonella
  • Uccelletti, Daniela
  • Bossu′, Maurizio
  • Bregnocchi, Agnese
  • Chandraiahgari, Chandrakanth Reddy
  • Zanni, Elena
  • De Angelis, Francesca

Abrégé

Disclosed is a dental adhesive including a polymeric adhesive and a nanofiller dispersed in the polymeric adhesive, the nanofiller being constituted by graphene nanostructures which are properly dispersed inside the polymer adhesive and over the surface of the adhesive layer without formation of agglomerates, so that the dental adhesive exhibits significant antimicrobial and antibiofilm properties against pathogens of the oral cavity.

Classes IPC  ?

  • A61K 6/027 - Emploi d'éléments non métalliques ou de leurs composés, p.ex. de carbone
  • A61K 6/71 - Charges
  • A61K 6/17 - Taille des particules
  • A61K 6/30 - Compositions pour fixer temporairement ou de façon permanente les dents ou les palais, p.ex. apprêts pour adhésifs dentaires
  • A61K 6/884 - Préparations pour la fabrication de dents artificielles, l’obturation ou le recouvrage des dents comprenant des résines naturelles ou synthétiques
  • A61K 6/76 - Charges comprenant des composés contenant du silicium
  • A61K 6/831 - Emploi d'éléments non métalliques ou de leurs composés, p.ex. de carbone

99.

Esculentin 1a derivatives and uses thereof

      
Numéro d'application 16112741
Numéro de brevet 10751440
Statut Délivré - en vigueur
Date de dépôt 2018-08-26
Date de la première publication 2018-12-20
Date d'octroi 2020-08-25
Propriétaire
  • UNIVERSITY OF HOUSTON SYSTEM (USA)
  • UNIVERSITA' DEGLI STUDI DI ROMA LA SAPIENZA (Italie)
Inventeur(s)
  • Mcdermott, Alison
  • Mangoni, Maria Luisa

Abrégé

Provided herein are synthetic antibacterial peptides that have a sequence at least 80% identical to a sequence shown in SEQ ID NO: 2 or the diastereomer thereof with a sequence shown in SEQ ID NO: 3 or pharmaceutical compositions thereof. Also provided are methods for stimulating wound healing via the synthetic antibacterial peptides and for forming an antimicrobial coating on contact lenses. In addition a device is provided that has a surface with a coating of the synthetic antibacterial peptides.

Classes IPC  ?

  • A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
  • A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
  • A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
  • C07K 14/46 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés
  • A61L 12/14 - Procédés ou appareils pour la désinfection ou la stérilisation des lentilles de contact; Accessoires à cet effet utilisant des substances chimiques des composés organiques non couverts par les groupes ou
  • A61P 27/02 - Agents ophtalmiques
  • A61K 38/04 - Peptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminée; Leurs dérivés
  • B29D 11/00 - Fabrication d'éléments optiques, p.ex. lentilles ou prismes
  • G02B 1/04 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES Éléments optiques caractérisés par la substance dont ils sont faits; Revêtements optiques pour éléments optiques faits de substances organiques, p.ex. plastiques

100.

Mechanical gun-type circumcision device with glans protection system for safe cutting and cauterization of the foreskin

      
Numéro d'application 15572003
Numéro de brevet 10667840
Statut Délivré - en vigueur
Date de dépôt 2016-05-06
Date de la première publication 2018-12-06
Date d'octroi 2020-06-02
Propriétaire UNIVERSITA' DEGLI STUDI DI ROMA ‘LA SAPIENZA’ (Italie)
Inventeur(s) Al Mansour, Monir

Abrégé

b) of the shearing template (23), and an actuating mechanism (40) for controlling rotation of the arms (30, 30′) in response to an actuation of the control member (15).

Classes IPC  ?

  • A61B 17/326 - Appareils à circoncire
  • A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
  • A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
  • A61B 17/32 - Instruments chirurgicaux coupants
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