Università degli Studi di Roma "La Sapienza" (Italie)
Inventeur(s)
Sorice, Maurizio
Misasi, Roberta
Garofalo, Tina
Longo, Agostina
Capozzi, Antonella
Manganelli, Valeria
Recalchi, Serena
Riitano, Gloria
Abrégé
The present invention relates to a process to perform an in vitro diagnosis of the antiphospholipid antibody syndrome. carried out on isolated samples of the subject to be diagnosed. Furthermore, the present invention relates to a kit which allows to perform a non-invasive diagnosis of the antiphospholipid antibody syndrome from an isolated sample of the subject for whom such a diagnosis has to be made.
G01N 33/564 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes
UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
Cairone, Francesco
Fabrizi, Giancarlo
Goggiamani, Antonella
Iazzetti, Antonia
Abrégé
The present invention generally relates to a conversion process of lipids or oils to obtain lower alcohol esters to be used in the production of automotive biodiesel. In particular, the invention relates to the conversion of organic acids and triglycerides of plant origin into corresponding esters of C1-C4 lower alcohols, preferably methyl alcohol. More specifically, the invention relates to a method for producing biodiesel starting from vegetable oils, such as corn oil deriving from post-fermentation. The process of the invention is quantitative in transforming both fatty acids and glycerides into the corresponding esters thanks to the presence of two immiscible phases: an organic phase, consisting of fatty acid methyl esters (FAME) and an aqueous phase consisting of water, glycerol and acid catalyst. The lower alcohol esters, in particular the methyl esters thus produced, can be used in automotive fuel blends.
C07C 67/02 - Préparation d'esters d'acides carboxyliques par interréaction des groupes ester, c. à d. par transestérification
C11C 3/10 - Graisses, huiles ou acides gras obtenus par transformation chimique des graisses, huiles ou acides gras, p.ex. ozonolyse par estérification des graisses ou des huiles par interestérification
3.
QUANTUM BERNOULLI FACTORY PHOTONIC CIRCUIT INDEPENDENT OF INPUT STATE BIAS
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATORY (Portugal)
CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
Inventeur(s)
Fagundes Galvão, Ernesto
Sciarrino, Fabio
Carvacho Vera, Gonzalo Alfredo
Hoch, Francesco
Spagnolo, Nicolò
Osellame, Roberto
Giordani, Taira
Castello, Luca
Abrégé
The present invention concerns a scheme that allows to create a Quantum-to-Quantum Bernoulli Factory, wherein random bits and qubits can be generated given input qubits, using a quantum photonic system that can take advantage of the different information coding approaches using states of single photons According to the invention, inversion, multiplication and sum operations can be realized with photon qubits and can be concatenated without generating noise.
G06F 7/544 - Méthodes ou dispositions pour effectuer des calculs en utilisant exclusivement une représentation numérique codée, p.ex. en utilisant une représentation binaire, ternaire, décimale utilisant des dispositifs non spécifiés pour l'évaluation de fonctions par calcul
G06E 3/00 - Dispositifs non prévus dans le groupe , p.ex. pour traiter des données analogiques hybrides
G06N 10/00 - Informatique quantique, c. à d. traitement de l’information fondé sur des phénomènes de mécanique quantique
4.
Method and Relative System for the Detection of a Viral Agent by Microwave Dielectric Spectroscopy
UNIVERSITA' DEGLI STUDI DI ROMA "LA SPIENZA" (Italie)
ISTITUTO SUPERIORE DI SANITÀ (Italie)
CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
Inventeur(s)
Bolli, Pietro
Brucalassi, Anna
Chiarucci, Simone
Cresci, Luca
Del Vecchio, Ciro
Di Ninni, Paola
Nesti, Renzo
Panella, Dario
Tozzi, Andrea
Apollonio, Francesca
Liberti, Micaela
Argentini, Claudio
Amendola, Antonello
Fiorentini, Cristiano
Fortuna, Claudia
Marsili, Giulia
Venturi, Giulietta
Barucci, Marco
Abrégé
A method for detecting a viral agent including the steps of placing a first sample that includes an isotonic solution in a waveguide which is axially delimited by a pair of containment elements that are substantially transparent to microwaves and define respective interfaces of the sample; transmitting a signal with frequency variable in a predetermined microwave band to the first sample; acquiring at least one dielectric parameter of the first sample as the frequency varies by means of transmission and reflection measurements; repeating the previous steps for a second sample; and performing a differential spectroscopic analysis on the parameters for assessing the presence of a viral agent in at least one of the samples.
G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c. à d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
5.
MULTIDIRECTIONAL HYSTERETIC DAMPER ENDOWED WITH NEGATIVE STIFFNESS
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Salvatore, Andrea
Carboni, Biagio
Lacarbonara, Walter
Abrégé
Provided is a mechanical device to be connected in series or in parallel to a structure to be protected from dynamic stresses so as to vary mechanical features of the system and control the general dynamic behavior. The mechanical device is a multi-purpose rheological element employable in various applications including vibration isolation, vibration absorption, shock absorption, energy dissipation, and other applications based on rheological force-movement behavior.
E04H 9/02 - Bâtiments, groupes de bâtiments ou abris conçus pour résister à des situations extérieures anormales, p.ex. à des bombardements, à des séismes ou à des climats extrêmes, ou pour se protéger de ces situations résistant aux séismes ou à l'effondrement du sol
F16F 15/04 - Suppression des vibrations dans les systèmes non rotatifs, p.ex. dans des systèmes alternatifs; Suppression des vibrations dans les systèmes rotatifs par l'utilisation d'organes ne se déplaçant pas avec le système rotatif utilisant des moyens élastiques
6.
USE OF MICRORNAS AS TOOLS FOR THE DIAGNOSIS AND DIFFERENTIATION OF TAUOPATHIES
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Denti, Michela Alessandra
Ricci, Leonardo
Grasso, Margherita
Zeni, Andrea
Piscopo, Paola
Rivabene, Roberto
Bruno, Giuseppe
Abrégé
The present invention relates to microRNAs for use in diagnostic methods for diagnosing and/or for distinguishing by diagnosis Alzheimer's disease (AD), Frontotemporal Dementia (FTD), and possibly other tauopathies, and/or for measuring therapeutic effect of a treatment of FTD or AD.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61K 31/7105 - Acides ribonucléiques naturels, c. à d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
7.
GFRAL RECEPTOR INHIBITOR FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Garofalo, Stefano
Limatola, Cristina
Cocozza, Germana
Abrégé
The invention relates to a GFRAL receptor inhibitor for use in the treatment of amyotrophic lateral sclerosis, in particular for the treatment of cachexia and/or for reducing weight loss in a subject suffering from amyotrophic lateral sclerosis. In particular, said inhibitor is a short hairpin RNA (shRNA). Pharmaceutical compositions and vectors comprising said inhibitor for the described uses also fall within the scope of the invention.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Felli, Nadia
Felicetti, Federica
Biffoni, Mauro
Flego, Michela
Arasi, Maria Beatrice
Palocci, Cleofe
Abrégé
The present invention discloses carriers with an onco-suppressive agent and selectively directed to a tumoral target for the treatment of metastatic melanoma resistant to a target therapy.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif
A61P 31/00 - Agents anti-infectieux, c. à d. antibiotiques, antiseptiques, chimiothérapeutiques
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p.ex. génie protéique ou administration de médicaments
9.
USE OF MOLECULES ISOLATED FROM BACTERIA PRESENT IN DIGESTATE PRODUCED BY BIOGAS PLANTS AS IMMUNOSTIMULANTS OF PLANT DEFENCE RESPONSES
UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
AGROLIO SRL (Italie)
Inventeur(s)
Lionetti, Vincenzo
Agresti, Savino
De Lorenzo, Giulia
Greco, Marco
Abrégé
A process is described for the valorisation of the microbial fraction contained in the waste material from biogas plants following anaerobic digestion of olive pomace, thanks to which an extract enriched in proteins and peptides of microbial origin is obtained for use as a plant protection product in agricultural production.
A01N 25/34 - Formes façonnées, p.ex. feuilles, non prévues dans l'un quelconque des autres sous-groupes du présent groupe principal
A01N 37/02 - Acides carboxyliques saturés ou leurs thio-analogues; Leurs dérivés
A01N 37/06 - Acides carboxyliques non saturés ou leurs thio-analogues; Leurs dérivés
A01N 37/44 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un contenant au moins un groupe carboxylique ou un thio-analogue, ou un de leurs dérivés, et un atome d'azote lié au même squelette carboné par une liaison simple ou double, cet atome d'azote ne faisant pas partie d'un dérivé ou d'un thio-analogue d'un
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
A01N 63/20 - Bactéries; Substances produites par des bactéries ou obtenues à partir de celles-ci
A01N 65/22 - Lamiaceae ou Labiatae [famille de la menthe], p.ex. thym, romarin, scutellaire, brunelle, lavande, perilla, menthe pouliot, menthe poivrée ou menthe verte
A01P 21/00 - Régulateurs de croissance des végétaux
C05F 3/00 - Engrais fabriqués à partir des excréments humains ou animaux, y compris le fumier
C05F 5/00 - Engrais fabriqués à partir de déchets de distillerie ou de sucreries, de mélasses, vinasses ou de déchets ou résidus similaires
C05F 7/00 - Engrais fabriqués à partir des eaux résiduaires ou d'épandage, wagage, limon ou masses similaires
C05F 9/00 - Engrais fabriqués à partir des ordures ménagères ou de ville
A01N 25/02 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'application; Substances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles contenant des liquides comme supports, diluants ou solvants
10.
WEARABLE AND FLEXIBLE ELECTROCHEMICAL SWEAT SENSOR CONSISTING OF A POLYMER COMPOSITE MEMBRANE CONTAINING GRAPHENE
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Sarto, Maria Sabrina
Bidsorkhi, Hossein Cheraghi
D'Aloia, Alessandro Giuseppe
Tamburrano, Alessio
Ballam, Lavanya Rani
Abrégé
A multi-composite electrochemical cell substantially consists of a thin polymer membrane including three different adjacent sectors, which are made of the same appropriately seamlessly modified polymer, incorporating in the polymer one or more conductive phases, or conductive fillers, such as graphene, metal, or a combination thereof. In the first sector the polymer material incorporates graphene nanoplatelets and acts as a cathode; in the second sector, interposed between the other two, the polymer material acts as an insulating spacer; in the third sector the polymer material incorporates graphene nanoplatelets and a metal filler or immersed metal contact rheophore, with negative standard reduction potential, and acts as an anode; wherein the metal filler is in the form of dispersed powder or dispersed flakes, or of a thin sheet incorporated in the polymer.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 5/1468 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p.ex. par des moyens polarographiques
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Galluccio, Gabriella
De Stefano, Adriana Assunta
Ierardo, Gaetano
Guerra, Claudio
Corridore, Denise
Guarnieri, Rosanna
Abrégé
Orthodontic device (100) comprising a body (3), a constraining surface (30) for the constraint to a tooth, preferably to a molar tooth, a first housing (6), a second housing (7), a first closing element (1) for the first housing (6), a second closing element (2) for the second housing (7); said first closing element (1) and second closing element (2) being able to be moved independently of each other so as to define a first open condition and a first closed condition of the first housing (6) and a second open condition and a second closed condition of the second housing (7), wherein said first condition of the first housing (6) is independent of said second condition of the second housing (7) and vice versa.
Università degli Studi di Roma "La Sapienza" (Italie)
Inventeur(s)
De Bellis, Giovanni
Abrégé
A measurement method (100) of the electric permittivity (ε) at 0 Hz of a substance (1), irrespective of the aggregation state, comprising the steps of: pre-arranging (101) a rheometer (2) comprising an electrorheology module (20), provided with a fixed first plate (21) and said movable second plate (22); connecting (102) a voltage generator (3) to said rheometer (2); placing (103) the substance (1) between said first plate (21) and said second plate (22); arranging (104) said second plate (22) at a distance (D) from said first plate (21); imposing (105) said potential difference (ΔV) at 0 Hz between said first plate (21) and said second plate (22); measuring (106) a normal force (F) to which said second plate (22) is subjected; converting (108) the normal force (F) to obtain the dielectric permittivity (ε) of the substance (1).
G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
G01N 11/14 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement en déplaçant un corps à l'intérieur du matériau en utilisant des corps en rotation, p.ex. moulinet
13.
BIOELECTROCHEMICAL METHOD FOR THE REMEDIATION OF WATER CONTAMINATED WITH CHLORINATED ALIPHATIC HYDROCARBONS
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Zeppilli, Marco
Dell'Armi, Edoardo
Majone, Mauro
Petrangeli Papini, Marco
Abrégé
An electrochemical method is described which stimulates microbial reactions for the removal of chlorinated aliphatic hydrocarbons from water contaminated with chlorinated aliphatic hydrocarbons, which finds use in the field of remediation of groundwater contaminated with chlorinated solvents.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Martirano, Luigi
Abrégé
An electronic electrical device, comprising a first electrical conductor for the input of electric current; a second electrical conductor for the output of electric current; a first electrical control device adapted to have two positions to electrically connect and disconnect the first electrical conductor and the second electrical conductor to/from each other; a second electrical control device adapted to have two positions to electrically connect and disconnect the first electrical conductor and the second electrical conductor to/from each other; first actuation means comprising a digital electronic controller; second actuation means comprising only mechanical and/or electromechanical components; wherein the first actuation means are adapted to vary the position of said first electrical control device independently of said second actuation means; and wherein the second actuation means are adapted to vary the position of said second electrical control device independently of said first actuation means.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Barone, Eugenio
Tramutola, Antonella
Perluigi, Marzia
Abrégé
Composition for use in the prevention and/or in the treatment of intellectual disability and neurodegenerative diseases in a subject with Down syndrome, wherein the composition comprises as an active agent at least one compound belonging to the class of dipeptidy 1-peptidase IV (DPP4) enzyme inhibitors and also to the class of gliptins.
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Guerra, Fabrizio
Ottolenghi, Livia
Di Giorgio, Roberto
Galluccio, Gabriella
Cicconetti, Andrea
Vozza, Iole
Nardi, Gianna Maria
Corridore, Denise
Mazur, Marta
Sansotta, Marco
Grassi, Roberta
Sansotta, Laura
Abrégé
An implant abutment, with the purpose of preserving the volume and trophism of the cortical bone and of the gingival tissue, comprises : an inserting portion; a contact portion touching the gingiva, integral with said inserting portion; a projecting portion with substantially circular shape projecting with respect to said contact portion to protect the gingival mucosa, integral with the contact portion through a concave profile; and a coronal portion integral with said projecting portion, whereon the prosthetic crown is installed, wherein the inserting portion, the contact portion, the projecting portion and the coronal portion are formed by one single piece which defines the abutment.
A61C 8/00 - Moyens destinés à être fixés à l'os de la mâchoire pour consolider les dents naturelles ou pour y assujettir des prothèses dentaires; Implants dentaires; Outils pour l'implantation
A61C 13/00 - Prothèses dentaires; Leurs procédés de fabrication
17.
REMOVABLE, WATERPROOF MULTI-LAYER COATING HAVING ANTIBACTERIAL PROPERTIES FOR CONTACT SURFACES AND METHOD FOR THE PREPARATION THEREOF
UNIVERSITA’ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
Sarto, Maria Sabrina
Uccelletti, Daniela
Polimeni, Antonella
De Bellis, Giovanni
Bossu', Maurizio
Bidsorkhi, Hossein Cheraghi
Bruni, Erika
Bellagamba, Irene
Ballam, Lavanya Rani
Abrégé
A multi-layer coating with antibacterial and anti-COVID properties which is usable in various environments, including hospitals, and which can be easily deposited by spraying on different surfaces and capable of providing an effective removable barrier against pathogens and bacteria, which waterproof coating is characterized in that it uses graphene nanoparticles as an antibacterial and anti-COVID agent deposited by spraying a polymer material as a host layer on the surface to promote the dispersion and uniform surface distribution thereof, the polymer material being directly adhered by spraying to the surface to be coated or sprayed on a second polymer, in turn sprayed on the surface to be coated, which is used as an element to promote the adhesion of the first polymer forming the antibacterial and anti-COVID coating to the surface to be coated.
A01N 59/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des éléments ou des composés inorganiques
A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges
C09D 1/00 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, à base de substances inorganiques
C09D 5/00 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, caractérisées par leur nature physique ou par les effets produits; Apprêts en pâte
UNIVERSITÀ DEGLI STUDI DI ROMA - LA SAPIENZA (Italie)
UNICAM - UNIVERSITÀ DEGLI STUDI DI CAMERINO (Italie)
SCUOLA NORMALE SUPERIORE (Italie)
Inventeur(s)
Caracciolo, Giulio
Pozzi, Daniela
Quagliarini, Erica
Renzi, Serena
Digiacomo, Luca
Amici, Augusto
Marchini, Cristina
Cui, Lishan
Wang, Junbiao
Cardarelli, Francesco
Abrégé
The present invention relates to the process of preparing multicomponent lipidic nanoparticles (LNP) with high cellular fusogenicity for the delivery of nucleic acids and in particular for DNA vaccination. The invention also relates to the nanoparticles thus obtained. In particular, the lipidic nanoparticles of the invention are obtained by combining cationic lipids and ionizable lipids in a specific ratio to each other to be administered both subcutaneously (intradermally or intramuscularly) and systemically with fewer side effects than the lipidic nanoparticles known in the art.
C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
C12N 15/00 - Techniques de mutation ou génie génétique; ADN ou ARN concernant le génie génétique, vecteurs, p.ex. plasmides, ou leur isolement, leur préparation ou leur purification; Utilisation d'hôtes pour ceux-ci
19.
NEURAL ELECTRODE MADE WITH SOFT POLYMERS AND RAPID PROTOTYPING TECHNIQUES
SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA (Italie)
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Zinno, Ciro
Giannotti, Alice
Cedrola, Ilaria
Redolfi Riva, Eugenio
Micera, Silvestro
Agnesi, Filippo
Rizzuto, Emanuele
Abrégé
The present invention relates to the field of implantable neural interface devices and, in particular, it refers to a new implantable polymeric neural electrode for extra- or intra-neural applications, as well as to a process for the simple and economically sustainable manufacture thereof. The present invention concerns an implantable neural electrode (100) comprising a flexible main body (10) extending between a first end (10a) and a second end (10b), configured to be at least partially disposed around or inserted within a target nerve, said main body (10) comprises:- a first electrically insulating layer (11); - a second electrically insulating layer (12); and - an electrically conductive pattern (20) interposed between said first and second layers; wherein said pattern (20) comprises a first portion (31), preferably partially outwardly exposed, configured to electrically come into contact with said target nerve, and a second portion (32), preferably outwardly exposed, configured to electrically connect said electrode to an external device; wherein said first layer (11) and second layer (12) comprise at least one polymeric material and said pattern (20) comprises at least one conductive hydrogel or polymer, and wherein said first layer (11), said second layer (12), and said pattern (20) do not contain metallic nanostructures or components. The process for the manufacturing of the implantable neural electrode (100) comprises the following steps: (i) providing a first composition comprising at least one electrically insulating polymeric material or precursors thereof, and a second composition comprising at least one electrically conductive hydrogel or polymer or precursors thereof, wherein said compositions have pseudo-elastic and/or thixotropic properties and do not contain metallic nanostructures or components; (ii) depositing a layer of said first composition on a flat surface of a substrate, so as to form a first electrically insulating layer (11) of said main body (10) comprising said at least one polymeric material; (iii) depositing a layer of said second composition onto the first layer (11) obtained in step (ii) so as to form, onto said first layer, an electrically conductive pattern (20) comprising said at least one conductive hydrogel or polymer; (iv) depositing a layer of said first composition onto the pattern (20) obtained in step (iii) so as to form, onto said pattern, a second electrically insulating layer (12) of said main body (10) comprising said at least one polymeric material, wherein said depositing is carried out in such a way that at least one first portion (31) and at least one second portion (32) of the pattern (20) are left at least partially outwardly exposed; wherein all depositing steps from (ii) to (iv) are carried out by means of an extrusion printing technique.
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
A61B 5/25 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet
A61B 5/263 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes
A61B 5/268 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes contenant des polymères conducteurs, p.ex. des polymères PEDOT:PSS
A61B 5/294 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’étude de la conduction nerveuse [NCS]
H05K 3/12 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché utilisant la technique de l'impression pour appliquer le matériau conducteur
H05K 3/36 - Assemblage de circuits imprimés avec d'autres circuits imprimés
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
H05K 1/11 - Eléments imprimés pour réaliser des connexions électriques avec ou entre des circuits imprimés
20.
COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR DETERMINING THE FETUS VENTRICULAR VOLUME FROM DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING, AND RELATED NMR VENTRICLE VOLUME ASSESSMENT METHOD
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Capuani, Silvia
Borrelli, Mattia
Pratesi, Giacomo
Di Trani, Maria Giovanna
Manganaro, Lucia
Abrégé
A computer-implemented method for determining a fetus ventricular volume from DWI images is provided. The computer-implemented method involves acquiring DWI images, with a pre-set voxel height, of a fetus ventricle, the acquisition being made with a single b-value selected in a range between 200 and 1000 s/mm2, selecting a ROI on each of the DWI images around the fetus ventricle, automatically clusterizing pixels in the ROI, obtaining clusterized DWI images, and calculating the fetus ventricular volume based on the number of pixels in the ROI for each of the DWI images and the pre-set voxel height. An NMR assessment system and an NMR assessment method implementing the method for determining the fetus ventricular volume are also provided.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Zizzari, Ilaria Grazia
Nuti, Marianna
Rughetti, Aurelia
Napoletano, Chiara
Di Filippo, Alessandra
Marchetti, Paolo
Botticelli, Andrea
Abrégé
The present invention relates to a method for rapidly and accurately determining the prognostic score and subsequent division into risk classes, in patients with metastatic renal carcinoma by acquiring and processing immunological analyses on the patients and combining those immunological analyses with the currently used IMDC classification.
G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
22.
A PROCESS FOR THE PREPARATION OF A PHONOGRAPH DISC
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Lucibello, Sabrina
Inglese, Giovanni
Abrégé
The present invention relates to a new process for the production of a phonograph disc for analog storing, recording and/or reproduction of a sound content, as well as to a phonograph disc obtainable by means of the aforementioned process.
G11B 11/16 - Enregistrement sur, ou reproduction depuis le même support d'enregistrement, dans lesquels, pour ces deux opérations, les procédés ou les moyens sont couverts par différents groupes principaux des groupes ou par différents sous-groupes du groupe ; Supports d'enregistrement correspondants utilisant l'enregistrement par gravure, déformation ou pressage mécaniques
G11B 3/70 - Supports d'enregistrement caractérisés par l'emploi d'un matériau spécifié ou par leur structure; Procédés ou appareils spécialement adaptés pour fabriquer les supports d'enregistrement
23.
METHOD OF MANUFACTURING A MIXTURE OF PURE COPPER AND CARBON NANOTUBES AND OF ADDITIVE MANUFACTURING OF A NANOCOMPOSITE MATERIAL HAVING A METALLIC MATRIX OF PURE COPPER REINFORCED WITH CARBON NANOTUBES BY MEANS OF SUCH MIXTURE
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Pettinacci, Valerio
Cortis, Daniele
Pandolfi, Francesco
Rago, Ilaria Carmela
Cavoto, Gianluca
Abrégé
The present invention concerns a method (1000) of producing a mixture of copper powders and carbon nanotubes. The method (1000) comprises the steps of: - functionalizing (1003) carbon nanotubes with a functional group such to increase the repulsive electrostatic forces among the carbon nanotubes, dispersing (1005) the functionalized carbon nanotubes in a solvent, said dispersion being carried out by means of sonication, - adding (1007) pure copper powder to the suspension obtained by the dispersion of the functionalized carbon nanotubes in the solvent in an amount such that the carbon nanotubes constitute between 0.05% and 0.5% by weight of the mixture of copper powders and carbon nanotubes, said copper powder comprising particles with a diameter comprised between 5 pm and 40 pm measured in accordance with ASTM B822 standard, and - mixing (1009) said suspension during the addition of the copper powder and until the solvent evaporates. Furthermore, the present invention also proposes a method (2000) of realizing an artefact using such a mixture of copper powders and carbon nanotubes.
UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
Cardarelli, Francesco
Beltram, Fabio
Tentori, Paolo Maria
Caracciolo, Giulio
Pozzi, Daniela
Abrégé
A determination of supramolecular organization in a substance includes target molecules and nanocarriers at least one of which is luminescent, based on a step of collecting of lifetime decay data of at least a standard substance pure or substantially pure where a known organization state of the target molecules and the nanocarriers is pure or substantially pure; and a step of comparing the standard data and test data from a test substance.
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
THE FIRST HOSPITAL OF CHINA MEDICAL UNIVERSITY (Italie)
Inventeur(s)
Stoller, Marco
Gao, Xinghua
Qi, Ruiqun
Zhang, Li
Xu, Xuegang
Vilardi, Giorgio
Abrégé
The present invention relates to a method for the production of SUV, LUV and/or GUV unilamellar liposomes performed using chemical synthesis and an SDR (Spinning Disk Reactor) apparatus which together allow the production of SUV, LUV and GUV unilamellar liposomes, preferably with a controlled size; the method has a low energy consumption without the need for further post-treatment steps.
C07C 403/24 - Dérivés du cyclohexane ou d'un cyclohexène, comportant une chaîne latérale avec une partie non saturée d'au moins quatre atomes de carbone en ligne, ladite partie étant directement attachée aux cycles cyclohexane ou cyclohexène, p.ex. vitamine A, bêt ayant des chaînes latérales substituées par des cycles non aromatiques à six chaînons, p.ex. bêta-carotène
27.
APPARATUS AND METHOD FOR SAMPLING AND DETECTING A PATHOGEN IN AIR
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (Italie)
UNIVERSITA' DEGLI STUDI DI MILANO (Italie)
POLITECNICO DI MILANO (Italie)
Inventeur(s)
Esposito, Francesca
Brucato, John Robert
Cozzolino, Fabio
Mongelluzzo, Giuseppe
Popa, Ciprian Lonut
Fornaro, Teresa
Meneghin, Andrea
Paglialunga, Daniele
Pareschi, Giovanni
De Cesare, Giampiero
Caputo, Domenico
Nascetti, Augusto
Costantini, Francesca
Lovecchio, Nicola
Iannascoli, Lorenzo
Mirasoli, Mara
Michelini, Elisa
Guardigli, Massimo
Clerici, Mario
Trabattoni, Daria
Biasin, Mara
Scaccabarozzi, Diego
Abrégé
An apparatus for sampling and detecting a pathogen in air comprising a first air sampling module, a second module for the isolation of viral RNA and a third module for amplification and detection of the viral RNA; thanks to the integration between the modules the apparatus is compact and portable and can be used for in situ sampling of air in closed environments such as ambulances or hospital rooms, air in the external environment and air exhaled by patients.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
G21K 4/00 - TECHNIQUES NON PRÉVUES AILLEURS POUR MANIPULER DES PARTICULES OU DES RAYONNEMENTS IONISANTS; DISPOSITIFS D'IRRADIATION; MICROSCOPES À RAYONS GAMMA OU À RAYONS X Écrans de conversion pour transformer une distribution spatiale de particules ou de rayonnements ionisants en images visibles, p.ex. écrans fluorescents
G01T 1/203 - Mesure de l'intensité de radiation avec des détecteurs à scintillation le détecteur étant fait de matières plastiques
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
UNIVERSITA' DEGLI STUDI DI GENOVA (Italie)
Inventeur(s)
Pellegrini, Vittorio
Brutti, Sergio
Silvestri, Laura
Celeste, Arcangelo
Abrégé
Li-rich transition metal oxides material, useful as cathode for Li-ion batteries and having general formula Li1.2+xMn0.54Ni0.13Co0.13-x-yAlyO2; where: 0.01≤x≤0.1; 0.01≤y≤0.1; and 0.03≤x+y<0.13.
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium
31.
ELECTROCHEMICAL TYPE BIOSENSORS COMPRISING RESORCARENES
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Botta, Bruno
Ghirga, Francesca
Quaglio, Deborah
Calcaterra, Andrea
Del Plato, Cristina
Mazzei, Francesco
Polli, Francesca
Abrégé
The present invention relates to novel resorc[4]arenes, such as pre-organized structure linkers for the development of high performance electrochemical biosensors.
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
32.
PHARMACEUTICAL COMPOSITION FOR THE CHEMICAL INHIBITION OF TGS1 IN THE THERAPEUTIC TREATMENT OF TELOMEROPATHIES
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
UNIVERSITÀ DEGLI STUDI DI TRIESTE (Italie)
Inventeur(s)
Raffa, Grazia Daniela
Cacchione, Stefano
Schoeftner, Stefan
Abrégé
The present invention relates to an inhibitor of the TGS1 enzyme and/or compositions comprising such inhibitor and one or more excipients for the therapeutic treatment of clinical conditions characterized and/or caused by telomeropathies.
A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p.ex. adénosine, acide adénylique
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
ASSOCIATION FRANÇAISE CONTRE LES MYOPATHIES – AFM-TELETHON (France)
Inventeur(s)
D'Amati, Giulia
Morea, Veronica
Pisano, Annalinda
Perli, Elena
Pignataro, Maria Gemma
Abrégé
The present invention relates to peptidomimetics of a short peptide from leucyl-tRNA synthetase, compositions comprising one or more of said peptidomimetics and their use for the treatment of syndromes caused by mutations of mt-tRNA (mitochondrial transfer RNA) genes, and medical treatments of said syndromes comprising the administration of said one or more peptidomimetics or compositions comprising the same.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES ? AFM-TELETHON (France)
Inventeur(s)
D'Amati, Giulia
Morea, Veronica
Pisano, Annalinda
Perli, Elena
Pignataro, Maria Gemma
Abrégé
The present invention relates to peptidomimetics of a short peptide from leucyl-tRNA synthetase, compositions comprising one or more of said peptidomimetics and their use for the treatment of syndromes caused by mutations of mt-tRNA (mitochondrial transfer RNA) genes, and medical treatments of said syndromes comprising the administration of said one or more peptidomimetics or compositions comprising the same.
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Mazzei, Franco
Polli, Francesca
Minisola, Salvatore
Abrégé
An electrode for electrochemical detection of an analyte in a biological sample, wherein the electrode is a molded, miniaturized, carbon-based electrode and comprises ( i ) magnetic nanoparticles coated with gold or silver, comprising on the respective surface at least one free amine group or at least one free carboxyl group, the nanoparticles being adsorbed on the surface of the electrode, and ( ii ) at least one ligand capable of specifically binding to the analyte, the at least one ligand being conjugated to the nanoparticles.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
ISTITUTO SUPERIORE DI SANITA' (Italie)
CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
Inventeur(s)
Bolli, Pietro
Brucalassi, Anna
Chiarucci, Simone
Cresci, Luca
Del Vecchio, Ciro
Di Ninni, Paola
Nesti, Renzo
Panella, Dario
Tozzi, Andrea
Apollonio, Francesca
Liberti, Micaela
Argentini, Claudio
Amendola, Antonello
Fiorentini, Cristiano
Fortuna, Claudia
Marsili, Giulia
Venturi, Giulietta
Barucci, Marco
Abrégé
A method for detecting a viral agent comprising the steps of placing a first sample comprising an isotonic solution in a waveguide which is axially delimited by a pair of containment elements that are substantially transparent to the microwaves and define respective interfaces of the sample; transmitting a signal with frequency variable in a predetermined microwave band to the first sample; acquiring at least one dielectric parameter of the first sample as the frequency varies by means of transmission and reflection measurements; repeating the previous steps for a second sample; and performing a differential spectroscopic analysis on said parameters for assessing the presence of a viral agent in at least one of the samples.
G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c. à d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
G01N 33/483 - Analyse physique de matériau biologique
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
37.
MULTIDIRECTIONAL HYSTERETIC DAMPER ENDOWED WITH NEGATIVE STIFFNESS
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Salvatore, Andrea
Carboni, Biagio
Lacarbonara, Walter
Abrégé
The present invention relates to a mechanical device to be connected in series or in parallel to a structure to be protected from dynamic stresses so as to vary the mechanical features of the system and control the general dynamic behavior. In fact, such a device represents a new multi-purpose rheological element which can be employed in various applications including : (1) vibration isolation, (2) vibration absorption, (3) shock absorption, (4) energy dissipation, (5) other applications based on rheological force-movement behavior (energy harvesting, sensors and actuators).
E04H 9/02 - Bâtiments, groupes de bâtiments ou abris conçus pour résister à des situations extérieures anormales, p.ex. à des bombardements, à des séismes ou à des climats extrêmes, ou pour se protéger de ces situations résistant aux séismes ou à l'effondrement du sol
B60R 19/34 - Aménagements concernant le montage des pare-chocs sur les véhicules comprenant des moyens de montage susceptibles de céder conçus pour être détruits à l'impact, p.ex. du type pare-chocs global
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Fazi, Francesco
Masciarelli, Silvia
Abrégé
The present invention belongs to the field of cancer therapy and relates to a composition or product comprising at least one retinoid compound, at least one arsenic compound and at least one proteasome inhibitor, for use in the treatment of acute myeloid leukemia (AML) where the tumor cells are positive for the FLT3-ITD mutation.
A61C 7/00 - Orthodontie, c. à d. obtention ou maintien de la position désirée des dents, p.ex. par redressage, nivellement, ajustement, séparation, ou par correction des malocclusions
A61C 3/03 - Instruments fonctionnant par vibration
A61C 1/08 - Eléments de machines spécialement adaptés à la chirurgie dentaire
40.
WEARABLE AND FLEXIBLE ELECTROCHEMICAL SWEAT SENSOR CONSISTING OF A POLYMER COMPOSITE MEMBRANE CONTAINING GRAPHENE
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Sarto, Maria Sabrina
Bidsorkhi, Hossein Cheraghi
D'Aloia, Alessandro Giuseppe
Tamburrano, Alessio
Ballam, Lavanya Rani
Abrégé
A multi-composite electrochemical cell substantially consists of a thin polymer membrane comprising three different adjacent sectors (S1, S2, S3), which are made of the same appropriately seamlessly modified polymer, incorporating in said polymer one or more conductive phases, or conductive fillers, such as graphene, metal, or a combination thereof. In the first sector (S1) the polymer material incorporates graphene nanoplatelets and acts as a cathode; in the second sector (S2), interposed between the other two, the polymer material acts as an insulating spacer; in the third sector (S3) the polymer material incorporates graphene nanoplatelets and a metal filler or immersed metal contact rheophore, with negative standard reduction potential, and acts as an anode; wherein said metal filler is in the form of dispersed powder or dispersed flakes, or of a thin sheet incorporated in the polymer.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
De Bellis, Giovanni
Abrégé
A measurement method (100) of the electric permittivity (ε) at 0 Hz of a substance (1), irrespective of the aggregation state, comprising the steps of: pre-arranging (101) a rheometer (2) comprising an electrorheology module (20), provided with a fixed first plate (21) and said movable second plate (22); connecting (102) a voltage generator (3) to said rheometer (2); placing (103) the substance (1) between said first plate (21) and said second plate (22); arranging (104) said second plate (22) at a distance (D) from said first plate (21); imposing (105) said potential difference (ΔV) at 0 Hz between said first plate (21) and said second plate (22); measuring (106) a normal force (F) to which said second plate (22) is subjected; converting (108) the normal force (F) to obtain the dielectric permittivity (ε) of the substance (1).
G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
G01N 11/00 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement
G01N 27/04 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance
42.
COMPOSITIONS FOR USE IN THE PREVENTION AND/ OR TREATMENT OF INTELLECTUAL DISABILITY AND NEURODEGENERATIVE DISEASES IN A SUBJECT WITH DOWN SYNDROME
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Barone, Eugenio
Tramutola, Antonella
Perluigi, Marzia
Abrégé
Composition for use in the prevention and/or in the treatment of intellectual disability and neurodegenerative diseases in a subject with Down syndrome, wherein the composition comprises as an active agent at least one compound belonging to the class of dipeptidyl-peptidase IV (DPP4) enzyme inhibitors and also to the class of gliptins.
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/4162 - 1,2-Diazoles condensés avec des systèmes hétérocycliques
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p.ex. pipérazine
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p.ex. rifampine, thiothixène
A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61K 31/403 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil condensés avec des carbocycles, p.ex. carbazole
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Martirano, Luigi
Abrégé
An electronic electrical device (100, 100'), comprising - a first electrical conductor (31) for the input of electric current; - a second electrical conductor (32) for the output of electric current; - a first electrical control device (1') adapted to have two positions to electrically connect and disconnect the first electrical conductor (31) and the second electrical conductor (32) to/from each other; - a second electrical control device (2, 2') adapted to have two positions to electrically connect and disconnect the first electrical conductor (31) and the second electrical conductor (32) to/from each other; - first actuation means (10) comprising a digital electronic controller (11); - second actuation means (20) comprising only mechanical and/or electromechanical components; wherein the first actuation means (10) are adapted to vary the position of said first electrical control device (1) independently of said second actuation means (20); and wherein the second actuation means (20) are adapted to vary the position of said second electrical control device (2, 2') independently of said first actuation means (10).
H01H 47/00 - Circuits autres que ceux appropriés à une application particulière du relais et prévue pour obtenir une caractéristique de fonctionnement donnée ou pour assurer un courant d'excitation donné
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA” (Italie)
UNIVERSITA' DEGLI STUDI DI TRENTO (Italie)
Inventeur(s)
Minucci, Saverio
De Wulf, Peter Arthur Irene
Romanenghi, Mauro
Cazzoli, Riccardo
Damizia, Michela
Silvestri, Romano
La Regina, Giuseppe
Coluccia, Antonio
Abrégé
The invention refers to new quinoline-4-carboxamide derivatives, pharmaceutical compositions containing thereof and the use of the same as inhibitors of Ndc80 kinetochore subcomplex-MT binding and of kinetochore-MT binding, more preferably for use in the treatment of cell proliferative disorders including cancers and drug-resistant cancer.
C07D 215/50 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 4
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 409/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
Imperi, Francesco
Ascenzioni, Fiorentina
Mori, Mattia
Ghirga, Francesca
Quaglio, Deborah
Corradi, Silvia
Lo Sciuto, Alessandra
Botta, Bruno
Calcaterra, Andrea
Stefanelli, Roberta
Abrégé
The present invention relates to diterpene compounds of general formula (I) capable of contrasting the antibiotic-resistance mediated by the ArnT enzyme, to their use as a medicament, in particular for use as an adjuvant of an antibiotic therapy in the treatment of antibiotic-resistant bacterial infections. The invention relates also to associations of one or more of the compounds of formula (I) with at least another active ingredient, in particular an antibacterial agent and/or an antibiotic, and compositions comprising one or more compounds of formula (I) or the association according to the present invention and at least one pharmaceutically acceptable excipient and/or carrier as well as to products, in particular medical devices, comprising at least a compound, an association or a composition according to the present invention. Moreover, the invention relates to the use of compounds of formula (I) to sensitize a bacterium to an antibacterial agent or an antibiotic, for example, colistin (polymyxin E) or polymyxin B and to an in vivo or in vitro method for sensitizing a bacterium to an antibacterial agent or an antibiotic comprising the exposure of said bacterium to one or more compounds of formula (I) together with colistin.
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Sorice, Maurizio
Misasi, Roberta
Garofalo, Tina
Longo, Agostina
Capozzi, Antonella
Manganelli, Valeria
Recalchi, Serena
Riitano, Gloria
Abrégé
The present invention relates to a process to perform an in vitro diagnosis of the antiphospholipid antibody syndrome, carried out on isolated samples of the subject to be diagnosed. Furthermore, the present invention relates to a kit which allows to perform a non-invasive diagnosis of the antiphospholipid antibody syndrome from an isolated sample of the subject for whom such a diagnosis has to be made.
G01N 33/564 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes
47.
A METHOD TO ASSIST IN THE EARLY DIAGNOSIS OF PANCREATIC ADENOCARCINOMA
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA (Italie)
Inventeur(s)
Caracciolo, Giulio
Pozzi, Daniela
Palchetti, Sara
Digiacomo, Luca
Caputo, Damiano
Coppola, Roberto
Abrégé
The present invention relates to a novel method for the early diagnosis of pancreatic adenocarcinoma, comprising the use of gold nanoparticles and a subsequent image analysis, a method of screening or monitoring pathological and non-pathological patients to identify pathological patients at risk of pancreatic adenocarcinoma, comprising the use of gold nanoparticles and a subsequent image analysis, a kit comprising reactants for the early diagnosis of pancreatic adenocarcinoma.
G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Sarto, Maria Sabrina
Uccelletti, Daniela
Polimeni, Antonella
De Bellis, Giovanni
Bossu', Maurizio
Bidsorkhi, Hossein Cheraghi
Bruni, Erika
Bellagamba, Irene
Ballam, Lavanya Rani
Abrégé
A multi-layer coating with antibacterial and anti-COVID properties which is usable in various environments, including hospitals, and which can be easily deposited by spraying on different surfaces and capable of providing an effective removable barrier against pathogens and bacteria, which waterproof coating is characterized in that it uses graphene nanoparticles as an antibacterial and anti-COVID agent deposited by spraying a polymer material as a host layer on the surface to promote the dispersion and uniform surface distribution thereof, said polymer material being directly adhered by spraying to the surface to be coated or sprayed on a second polymer, in turn sprayed on the surface to be coated, which is used as an element to promote the adhesion of the first polymer forming the antibacterial and anti-COVID coating to said surface to be coated.
C09D 5/00 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, caractérisées par leur nature physique ou par les effets produits; Apprêts en pâte
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Caracciolo, Giulio
Di Carlo, Angelina
Pozzi, Daniela
Digiacomo, Luca
Di Santo, Riccardo
Quagliarini, Erica
Abrégé
The invention relates to a method for the diagnosis of glioblastoma multiforme which comprises the use of graphene oxide nanoparticles and a subsequent image analysis, a method of screening or monitoring of pathological and non-pathological patients to identify pathological patients at risk of glioblastoma multiforme, which comprises the use of graphene oxide nanoparticles and subsequent image analysis, a kit comprising reagents for the early diagnosis of glioblastoma multiforme.
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
50.
COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR DETERMINING THE FETUS VENTRICULAR VOLUME FROM DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING, AND RELATED NMR VENTRICLE VOLUME ASSESSMENT METHOD
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Capuani, Silvia
Borrelli, Mattia
Pratesi, Giacomo
Di Trani, Maria Giovanna
Manganaro, Lucia
Abrégé
bb-value (111) selected in the range between 200 and 1000 s/mm2; B. Selecting a ROI (122,123,124,125) on each of the DWI images around the ventricle; C. Automatically clusterizing (127) the pixels in the ROI, obtaining clusterized DWI images; and D. Calculating (130) the ventricle volume based on the number of pixels in the ROI for each of the DWI images and the pre-set voxel height. The method further concerns a NMR assessment system and a NMR assessment method that uses the invention method.
UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Marchese, Cinzia
Angeloni, Antonio
Ceccarelli, Simona
D'Amici, Sirio
Abrégé
The present invention refers to a microorganism characterized in that it is genetically modified to express the human growth factor of keratinocytes (KGF/FGF7) or its functional orthologues, derivatives or fragments.
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
Cardarelli, Francesco
Beltram, Fabio
Tentori, Paolo Maria
Caracciolo, Giulio
Pozzi, Daniela
Abrégé
The present invention relates to determination of supramolecular organization in a substance including target molecules and nanocarriers at least one of which is luminescent, based on a step of collecting of lifetime decay data of at least a standard substance pure or substantially pure wherein a known organization state of the target molecules and the nanocarriers is pure or substantially pure; and a step of comparing the standard data and test data from a test substance.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (Italie)
UNIVERSITA' DEGLI STUDI DI MILANO (Italie)
POLITECNICO DI MILANO (Italie)
Inventeur(s)
Esposito, Francesca
Brucato, John Robert
Cozzolino, Fabio
Mongelluzzo, Giuseppe
Popa, Ciprian Ionut
Fornaro, Teresa
Meneghin, Andrea
Paglialunga, Daniele
Pareschi, Giovanni
De Cesare, Giampiero
Caputo, Domenico
Nascetti, Augusto
Costantini, Francesca
Lovecchio, Nicola
Iannascoli, Lorenzo
Mirasoli, Mara
Michelini, Elisa
Guardigli, Massimo
Clerici, Mario
Trabattoni, Daria
Biasin, Mara
Scaccabarozzi, Diego
Abrégé
An apparatus (1) for sampling and detecting a pathogen in air comprising a first air sampling module (A), a second module (B) for the isolation of viral RNA and a third module (C) for amplification and detection of the viral RNA; thanks to the integration between the modules (A, B, C) the apparatus (1) is compact and portable and can be used for in situ sampling of air in closed environments such as ambulances or hospital rooms, air in the external environment and air exhaled by patients.
H01M 4/505 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de manganèse d'oxydes ou d'hydroxydes mixtes contenant du manganèse pour insérer ou intercaler des métaux légers, p.ex. LiMn2O4 ou LiMn2OxFy
H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p.ex. LiNiO2, LiCoO2 ou LiCoOxFy
56.
PHARMACEUTICAL COMPOSITION FOR THE CHEMICAL INHIBITION OF TGS1 IN THE THERAPEUTIC TREATMENT OF TELOMEROPATHIES
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
UNIVERSITA DEGLI STUDI DI TRIESTE (Italie)
Inventeur(s)
Raffa, Grazia Daniela
Cacchione, Stefano
Schoeftner, Stefan
Abrégé
The present invention relates to an inhibitor of the TGS1 enzyme and/or compositions comprising such inhibitor and one or more excipients for the therapeutic treatment of clinical conditions characterized and/or caused by telomeropathies.
A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p.ex. adénosine, acide adénylique
A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
57.
PHARMACEUTICAL COMPOSITION FOR THE CHEMICAL INHIBITION OF TGS1 IN THE THERAPEUTIC TREATMENT OF TELOMEROPATHIES
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
UNIVERSITÀ DEGLI STUDI DI TRIESTE (Italie)
Inventeur(s)
Raffa, Grazia Daniela
Cacchione, Stefano
Schoeftner, Stefan
Abrégé
The present invention relates to an inhibitor of the TGS1 enzyme and/or compositions comprising such inhibitor and one or more excipients for the therapeutic treatment of clinical conditions characterized and/or caused by telomeropathies.
A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p.ex. adénosine, acide adénylique
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
Botta, Bruno
Screpanti, Isabella
Tottone, Luca
Zhdanoskaya, Nadezda
Ingallina, Cinzia
Giulimondi, Francesca
Quaglio, Deborah
Palermo, Rocco
Mori, Mattia
Ghirga, Francesca
Abrégé
Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
C07D 309/32 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
C07C 49/248 - Composés non saturés comportant des groupes cétone liés à des atomes de carbone acycliques contenant des groupes hydroxyle contenant des cycles aromatiques à six chaînons avec insaturation autre que celle des cycles aromatiques
59.
PROCESS FOR THE SYNTHESIS AND PRODUCTION OF NANO- OR MICRO-ZEOLITES USING A ROTATING DISC REACTOR
UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
Vilardi, Giorgio
Stoller, Marco
Ferrini, Mauro
Saviano, Giovanna
Santonicola, Mariagabriella
Abrégé
The present invention relates to an industrial production process performed using a chemical synthesis and Spinning Disk Reactor (SDR) apparatus which together make it possible to produce crystalline synthetic nanostructure d or microstructured zeolites or crystalline synthetic nanostructure d or micro structure d zeolite-type (zeotype) materials without the addition of other chemical agents (or templates) to guide deposition, which would have to be removed by appropriate post-treatment and which would render the zeolites or zeotype material unsuitable for use in biomedical applications (separation treatment with heavy liquids.
C01B 39/02 - Zéolites aluminosilicates cristallines; Leurs composés isomorphes; Leur préparation directe; Leur préparation à partir d'un mélange réactionnel contenant une zéolite cristalline d'un autre type, ou à partir de réactants préformés; Leur post-traitement
UNIVERSITA' DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
Vidoli, Stefano
Brunetti, Matteo
Abrégé
In a method for manufacturing prestressed shells having tunable bistability, in order to determine the appropriate prestress to be applied to the bistable structure/shell, it provides: clamping a shell by applying a predetermined curvature on a portion of its edge; defining a discrete shell model dependent on a small number of configuration parameters q_i, (i<5), by projecting the non-linear shell model of Marguerre-von Kármán onto an appropriate finite dimensional space so that the projection does not significantly alter the strain elastic energy; tracing the stability maps in the space of the design parameters by minimizing the discrete representation of the strain elastic energy E(q_i;p_i) thus obtained; and choosing the design parameters providing the prestress needed to obtain the desired response in terms of project requirements.
B29C 70/54 - Façonnage de matières composites, c. à d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p.ex. des inserts comprenant uniquement des renforcements, p.ex. matières plastiques auto-renforçantes opération de façonnage des matières composites comprenant uniquement des renforcements - Parties constitutives, détails ou accessoires; Opérations auxiliaires
B64F 5/10 - Fabrication ou assemblage d’aéronefs, p.ex. gabarits à cet effet
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Fusco, Ciro
Lombardi, Mara
Di Mascio, Paola
Rossi, Giuliano
Sciaretta, Nicolò
Cantisani, Giuseppe
Abrégé
A support system (100) for an evacuation of a user from a road or railway tunnel (102), which includes a first pedestrian evacuation lane (108) between a first and a second emergency exit (104, 106), is described. The support system comprises several radiofrequency devices (110) each associated with a predetermined unique identifier and each installed in a predetermined tunnel position. Each radiofrequency device has a certain coverage area (112) wherein it transmits support information to a user device (U) in the coverage area. The radiofrequency devices (110) are installed on an internal wall (114) of the tunnel (102) so that the whole of the coverage areas (112) covers the entire first pedestrian evacuation lane (108). The user device includes a storage means which stores the association between the predetermined unique identifier and the predetermined tunnel position of the radiofrequency devices (110). The support information includes a first location data item (MAJOR) comprising the predetermined unique identifier of the radiofrequency device (110) which transmits the support information to the user device (U). The user device (U) determines its position in the tunnel (102) as a function of the location data item (MAJOR) comprised in the received support information.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Fazi, Francesco
Masciarelli, Silvia
Abrégé
The present invention belongs to the field of cancer therapy and relates to a composition or product comprising at least one retinoid compound, at least one arsenic compound and at least one proteasome inhibitor, for use in the treatment of acute myeloid leukemia (AML) where the tumor cells are positive for the FLT3-ITD mutation.
A61C 7/00 - Orthodontie, c. à d. obtention ou maintien de la position désirée des dents, p.ex. par redressage, nivellement, ajustement, séparation, ou par correction des malocclusions
A61C 1/08 - Eléments de machines spécialement adaptés à la chirurgie dentaire
A61C 3/03 - Instruments fonctionnant par vibration
64.
A NEW METHOD FOR DIAGNOSING A THYROID TUMOUR AND KIT THEREOF
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Filetti, Sebastiano
Durante, Cosimo
Verrienti, Antonella
Sponziello, Marialuisa
Grani, Giorgio
Abrégé
in vitroin vitro diagnosis of a thyroid tumour, comprising the steps of identifying the presence of gene mutations and identifying the expression of the levels of a specific miRNA, and relative kit.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
65.
MiRNAs for treatment and in vitro diagnosis of drug resistant tumors
ISTITUTO NAZIONALE TUMORI I.R.C.C.S. “FONDAZIONE G. PASCALE” (Italie)
UNIVERSITA' DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
Ciliberto, Gennaro
Ascierto, Paolo Antonio
Fattore, Luigi
Botti, Gerardo
Mancini, Rita
Abrégé
miRNAs for in vitro diagnosis of resistance of tumors to BRAF/MEK pathway (also named as MAPK 5 pathway) inhibiting drugs and for treatment of tumors which are treated with said drugs, such as melanoma, by stimulating or inhibiting the expression of down-regulated or up-regulated miRNAs, respectively.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
66.
USE OF ESCULENTIN AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF CYSTIC FIBROSIS
UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
FONDAZIONE PER LA RICERCA SULLA FIBROSI CISTICA - ONLUS (Italie)
ISTITUTO GIANNINA GASLINI (Italie)
Inventeur(s)
Mangoni, Maria Luisa
Ferrera, Loretta
Abrégé
Are disclosed pharmaceutical compositions comprising as active ingredients Esculentin-1a(1-21)NH2 and/or Esculentin diastereomer Esc(1-21)-1c for use for restoring dysregulation of water and/or ions content and/or composition of the periciliary liquid due to mutations of the CFTR gene encoding for Cystic fibrosis transmembrane conductance regulator (CFTR) and for use for the treatment of cystic fibrosis.
A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
C07K 14/46 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés
67.
USE OF ESCULENTIN AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF CYSTIC FIBROSIS
UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
FONDAZIONE PER LA RICERCA SULLA FIBROSI CISTICA – ONLUS (Italie)
ISTITUTO GIANNINA GASLINI (Italie)
Inventeur(s)
Mangoni, Maria Luisa
Ferrera, Loretta
Abrégé
22 and/or Esculentin diastereomer Esc(1-21)-1c for use for restoring dysregulation of water and/or ions content and/or composition of the periciliary liquid due to mutations of the CFTR gene encoding for Cystic fibrosis transmembrane conductance regulator (CFTR) and for use for the treatment of cystic fibrosis.
UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
Bianco, Armandodoriano
Serafini, Ilaria
Cavallaro, Giuseppe
Lazzara, Giuseppe
Abrégé
−1 measured at 25.0±0.1° C., kit and method for finishing and/or preservation and/or restoration and/or renovation and/or repairing and/or consolidation of manufactures, in particular ancient manufactures are disclosed.
UNIVERSITA' DEGLI STUDI DI ROMA LA SAPIENZA (Italie)
Inventeur(s)
Sterpetti, Antonio Vittorio
Abrégé
Method and relative system for the measurement of haemodynamic indices, said method comprising: acquiring an ultrasound image of at least one segment of an arterial vessel; identifying in said image at least one sample volume; obtaining a time series indicating the blood velocity, or velocity signal (9), in said sample volume and in at least one cardiac cycle; calculating, by means of a processor, a first area (4) equal to the area subtended by the velocity signal (9) between the sample (6) relating to the instant of systole start of said at least one cardiac cycle and the sample (7) of systolic peak; calculating, by means of a processor, a second area (5) subtended by the velocity signal (9) between the sample (7) of systolic peak and the sample (8) relating to the instant of end diastole of said at least one cardiac cycle; calculating the relationship between the second area (5) and the first area (4); selecting a time instant of interest in said at least one cardiac cycle; obtaining the spatial distribution of the velocity in said time instant of interest, or instantaneous distribution of the velocity; identifying the maximum value and the minimum value of the instantaneous distribution of the velocity; and calculating the relationship between the maximum value and the minimum value.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p.ex. en utilisant des cathéters
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
70.
A METHOD TO ASSIST IN THE EARLY DIAGNOSIS OF PANCREATIC ADENOCARCINOMA
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA (Italie)
Inventeur(s)
Caracciolo, Giulio
Pozzi, Daniela
Palchetti, Sara
Digiacomo, Luca
Caputo, Damiano
Coppola, Roberto
Abrégé
The present invention relates to a novel method for the early diagnosis of pancreatic adenocarcinoma, comprising the use of gold nanoparticles and a subsequent image analysis, a method of screening or monitoring pathological and non-pathological patients to identify pathological patients at risk of pancreatic adenocarcinoma, comprising the use of gold nanoparticles and a subsequent image analysis, a kit comprising reactants for the early diagnosis of pancreatic adenocarcinoma.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
Imperi, Francesco
Ascenzioni, Fiorentina
Mori, Mattia
Ghirga, Francesca
Quaglio, Deborah
Corradi, Silvia
Lo Sciuto, Alessandra
Botta, Bruno
Calcaterra, Andrea
Stefanelli, Roberta
Abrégé
The present invention relates to diterpene compounds of general formula (I) capable of contrasting the antibiotic-resistance mediated by the ArnT enzyme, to their use as a medicament, in particular for use as an adjuvant of an antibiotic therapy in the treatment of antibiotic-resistant bacterial infections. The invention relates also to associations of one or more of the compounds of formula (I) with at least another active ingredient, in particular an antibacterial agent and/or an antibiotic, and compositions comprising one or more compounds of formula (I) or the association according to the present invention and at least one pharmaceutically acceptable excipient and/or carrier as well as to products, in particular medical devices, comprising at least a compound, an association or a composition according to the present invention. Moreover, the invention relates to the use of compounds of formula (I) to sensitize a bacterium to an antibacterial agent or an antibiotic, for example, colistin (polymyxin E) or polymyxin B and to an in vivo or in vitro method for sensitizing a bacterium to an antibacterial agent or an antibiotic comprising the exposure of said bacterium to one or more compounds of formula (I) together with colistin.
UNIVERSITA' DEGLI STUDI DI ROMA LA SAPIENZA (Italie)
Inventeur(s)
Mcdermott, Alison
Mangoni, Maria Luisa
Abrégé
Provided herein are synthetic antibacterial peptides that have a sequence at least 80% identical to a sequence shown in SEQ ID NO: 2 or the diastereomer thereof with a sequence shown in SEQ ID NO: 3 or pharmaceutical compositions thereof. Also provided are methods for stimulating wound healing via the synthetic antibacterial peptides and for forming an antimicrobial coating on contact lenses. In addition a device is provided that has a surface with a coating of the synthetic antibacterial peptides.
A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
C07K 14/46 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés
A61L 12/14 - Procédés ou appareils pour la désinfection ou la stérilisation des lentilles de contact; Accessoires à cet effet utilisant des substances chimiques des composés organiques non couverts par les groupes ou
A61K 38/04 - Peptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminée; Leurs dérivés
B29D 11/00 - Fabrication d'éléments optiques, p.ex. lentilles ou prismes
G02B 1/04 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES Éléments optiques caractérisés par la substance dont ils sont faits; Revêtements optiques pour éléments optiques faits de substances organiques, p.ex. plastiques
73.
STABLE SYSTEM FOR THE IN VITRO CULTURE OF CEREBELLAR GRANULE CELL PRECURSORS (GCP), STABLE METHOD FOR THE IN VITRO CULTURE OF SAID CELLS AND USE OF SAID SYSTEM OR METHOD FOR IN VITRO CULTURE
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
Giannini, Giuseppe
Colicchia, Valeria
Capalbo, Carlo
Fabretti, Francesca
Di Giulio, Stefano
Belardinilli, Francesca
Petroni, Marialaura
Roncero, Maria Sahùn
Abrégé
in vitroin vitro in vitro in vitro models for study of the pathophysiology of cerebellar granules or use of the above-mentioned culture system or method of culture for use in gene therapy and cell therapy approaches to cerebellar diseases caused by damage or neurodegeneration.
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Marchese, Cinzia
Angeloni, Antonio
Ceccarelli, Simona
D'Amici, Sirio
Abrégé
The present invention refers to a microorganism characterized in that it is genetically modified to express the human growth factor of keratinocytes (KGF / FGF7) or its functional orthologues, derivatives or fragments.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSERM INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (France)
UNIVERSITÀ TELEMATICA ECAMPUS (Italie)
UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
Gasco, Paolo
Multhoff, Gabriele
Adamo, Sergio
Coletti, Dario
Macaluso, Filippo
D'Amico, Daniela
Trovato, Eleonora
Farina, Felicia
Cappello, Francesco
Campanella, Claudia
Marino Gammazza, Antonella
Barone, Rosario
Abrégé
A process for the in vitro preparation of vesicles containing as an active ingredient the heat shock protein of 60 kDa Hsp60 and the use of vesicles as a medicament in particular for the treatment of muscular atrophy or sarcopenia and of cachexia is described.
C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
45 - Services juridiques; services de sécurité; services personnels pour individus
Produits et services
Providing cultural activities; Cultural services; Training; Organisation of sporting events; Publishing, reporting, and writing of texts; Training in the field of medicine; Teaching services relating to the medical field; Organization of seminars and conventions in the field of medicine; Conducting educational support programmes for carers; Providing continuing nursing education courses; Provision of keep fit facilities; Supervision of physical exercise; Provision of information relating to sports; Health club services [health and fitness training]; Exercise [fitness] training services; Physical fitness instruction; Recreation and training services; Sporting and recreational activities; Exercise [fitness] advisory services; Instruction courses relating to physical fitness; Consultancy relating to physical fitness training; Health and fitness training; Instruction in group exercise; Education services relating to health; Training services relating to occupational health; Instruction in body grooming; Education in the field of occupational health and safety; Vocational education relating to avoidance of health related problems; Education and training services in the field of occupational health and safety; Bodywork therapy instruction; Health and wellness training; Entertainment services in the nature of organizing social entertainment events; Personal coaching [training]. Providing scientific information in the field of medical disorders and their treatment; Scientific research for medical purposes; Scientific research in the field of social medicine; Information technology services for the pharmaceutical and healthcare industries; Scientific research for medical purposes in the area of cancerous diseases; Consultancy relating to research and development in the field of therapeutics; Clinical research; Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Providing information on clinical studies via an interactive website; Medical research; Clinical trials; Rental of science and technology equipment; Provision of information and data relating to medical and veterinary research and development. Medical services; Rental of equipment for human healthcare; Dentistry; Mental health services; Opticians' services; Human healthcare services; Medical screening; Medical clinic services; Provision of medical services; Medical examination of individuals; Medical equipment rental; Physician services; Conducting of medical examinations; Compilation of medical reports; Regenerative medicine services; Residential medical treatment services; Medical screening relating to the heart; Medical testing services relating to the diagnosis and treatment of disease; Providing medical support in the monitoring of patients receiving medical treatments; Medical assistance consultancy provided by doctors and other specialized medical personnel; Medical analysis services for diagnostic and treatment purposes provided by medical laboratories; Providing nutritional information about food for medical weight loss purposes; Providing nutritional information about drinks for medical weight loss purposes; Charitable services, namely, providing medical services to needy persons; Advisory services relating to medical apparatus and instruments; Consultancy and information services relating to medical products; Providing news and information in the field of medicine; Providing online medical record services other than dentistry; Medical and healthcare services; Medical health assessment services; Advisory services relating to medical services; Advisory services relating to medical problems; Medical treatment services; Medical services in the field of treatment of chronic pain; Medical treatment services provided by clinics and hospitals; Provision of information relating to medicine; Counselling relating to the psychological treatment of medical ailments; Counselling relating to the psychological relief of medical ailments; Dispensing of pharmaceuticals; Home-visit nursing care; Assisting individuals to stop smoking; Health advice and information services; Nutrition consultancy; Dietetic advisory services; Consulting services relating to health care; Advice relating to the personal welfare of elderly people [health]; Advice relating to allergies; Nutrition counseling; Health screening; Physiotherapy; Providing breastfeeding information; Providing health care information by telephone; Providing information relating to physical examinations; Providing information relating to dietary and nutritional supplements; Providing smoking cessation treatment services; Providing weight loss program services; Provision of health care services in domestic homes; Health assessment surveys; Massage; Monitoring of patients; Genetic counseling; Counseling relating to occupational therapy; Therapeutical pilates; Family planning; Health risk assessment surveys; Rehabilitation of alcohol addicted patients; Rehabilitation of narcotic addicted patients; Rehabilitation of drug addicted patients; Physical rehabilitation; Health centre services; Laboratory analysis services relating to the treatment of persons; Home health care services; Health care in the nature of health maintenance organizations; Health care services offered through a network of health care providers on a contract basis; Lactation consulting services; Cryotherapy services; Postnatal care services for women; Electro therapy services for physiotherapy; Stress management services; Information services relating to health care; Medical information services provided via the Internet; Meditation services; Occupational therapy and rehabilitation; Occupational therapy services; Pharmaceutical services; Weight reduction services; Health care relating to therapeutic massage; Health care relating to remedial exercise; Therapy services; Music therapy for physical, psychological and cognitive purposes; Thalassotherapy; Fitness testing; Therapeutic treatment of the face; Therapeutic treatment of the body; Professional consultancy relating to health care; Addiction treatment services; Consultancy in the field of body and beauty care; Personality assessment services [mental health services]; Development of individual physical rehabilitation programmes; Providing physical rehabilitation facilities; Providing mental rehabilitation facilities. Consultancy services relating to health and safety; Information services relating to health and safety; Consultancy on regulations on safety at work; Consulting in the field of personal relationships; Health and safety risk assessment services; Marriage guidance counselling; Bereavement support; Bereavement counselling; Providing patient advocate services to hospital patients and patients in long term care facilities; Providing personal support services for cancer patients and their families; Providing personal support services for families of patients with life threatening disorders; Provision of emotional support to families; Online social networking services accessible by means of downloadable mobile applications; Online social networking services.
78.
ANAEROBIC DIGESTION WITH A DYNAMIC RECIRCULATION OF DIGESTATE
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Gottardo, Marco
Pavan, Paolo
Cavinato, Cristina
Micolucci, Federico
Bolzonella, David
Majone, Mauro
Valentino, Francesco
Abrégé
The object of the present invention consists of a method for optimizing the biological production of gaseous hydrogen and volatile fatty acids (VFA) by means of the anaerobic digestion process with separate phases. This optimization is achieved by controlling the pH of the reaction medium in the fermentation reactor through the recirculation of the digestate exiting the digestion reactor. The recirculation ratio is managed by an algorithm that automatically establishes the recirculation flow rate for maintaining the pH in the fermentation reactor at a value close to the optimal one through inputs coming from probes inside the two reactors and at the same time prevents an excessive accumulation of ammonia in the system.
C12P 3/00 - Préparation d'éléments ou de composés inorganiques à l'exception du dioxyde de carbone
C12P 5/02 - Préparation des hydrocarbures acycliques
C12P 7/00 - Préparation de composés organiques contenant de l'oxygène
C12P 7/40 - Préparation de composés organiques contenant de l'oxygène contenant un groupe carboxyle
C12P 7/64 - Graisses; Huiles; Cires de type ester; Acides gras supérieurs, c. à d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyle; Huiles ou graisses oxydées
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p.ex. fermenteurs commandés automatiquement
79.
METHOD FOR THE REALISATION OF PRESTRESSED SHELLS WITH A CONTROLLED BISTABILITY
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Vidoli, Stefano
Brunetti, Matteo
Abrégé
design parameters pii = {hii =1,2...;mii =1,2...;chii , mii cqii > (i < 5)E(qii , pii )FF22 ≤ F ≤ F11 F > Ft11 1 - changing the critical transition loads also during the operation of the structure.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Irrera, Fernanda
Abrégé
The present invention relates to a monitoring system for monitoring the motor activity of a persons's lower limbs. In particular, said system comprises a first electronic device which is a slave device (1) and a second electronic device which is a master device. Said slave device (1) and said master device (2) acquire data and cooperate to each other so that the master device (2) calculates at least one index, on the basis of the data acquired by each electronic device, in order to monitor the motor activity. The present invention relates also to a method for monitoring the motor activity of a person's lower limbs.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
09 - Appareils et instruments scientifiques et électriques
14 - Métaux précieux et leurs alliages; bijouterie; horlogerie
16 - Papier, carton et produits en ces matières
18 - Cuir et imitations du cuir
20 - Meubles et produits décoratifs
21 - Ustensiles, récipients, matériaux pour le ménage; verre; porcelaine; faience
25 - Vêtements; chaussures; chapellerie
26 - Articles de fantaisie; mercerie; fleurs artificielles, cheveux postiches
34 - Tabac; articles pour fumeurs
35 - Publicité; Affaires commerciales
38 - Services de télécommunications
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
43 - Services de restauration (alimentation); hébergement temporaire
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Recorded content; Computer databases; Media content; Computer software; Games software; Application software; Communication and networking software; Data and file management and database software; Media and publishing software; Office and business applications; Artificial intelligence and machine learning software; Software for monitoring, controlling and running physical world operations; System and system support software, and firmware; Firmware and device drivers; Operating systems; Utility, security and cryptography software; Virtual and augmented reality software; Web application and server software; Content management software; E-commerce and e-payment software; Information technology and audio-visual, multimedia and photographic devices; Communications equipment; Computer networking and data communications equipment; Point-to-point communications equipment; Broadcasting equipment; Antennas and aerials as communications apparatus; Data storage devices and media; Replicating apparatus; Photocopiers; Image scanners; Printers; Data processing equipment and accessories (electrical and mechanical); Calculators; Ticket dispensers; Payment terminals, money dispensing and sorting devices; Coin-operated mechanisms; Peripherals adapted for use with computers and other smart devices; Computers and computer hardware; Computer components and parts; Audio/visual and photographic devices; Audio devices and radio receivers; Display devices, television receivers and film and video devices; Image capturing and developing devices; Signal cables for IT, AV and telecommunication; Magnets, magnetizers and demagnetizers; Scientific and laboratory devices for treatment using electricity; Apparatus, instruments and cables for electricity; Apparatus and instruments for accumulating and storing electricity; Apparatus and instruments for controlling electricity; Photovoltaic apparatus for generating electricity; Electric and electronic components; Cables and wires; Electrical circuits and circuit boards; Antennas and aerials as components; Optical devices, enhancers and correctors; Optical enhancers; Lasers; Glasses, sunglasses and contact lenses; Corrective eyewear; Sunglasses; Safety, security, protection and signalling devices; Alarms and warning equipment; Access control devices; Signalling apparatus; Protective and safety equipment; Head protection; Eye protection; Diving equipment; Navigation, guidance, tracking, targeting and map making devices; Measuring, detecting and monitoring instruments, indicators and controllers; Monitoring instruments; Sensors and detectors; Testing and quality control devices; Measuring, counting, alignment and calibrating instruments; Data loggers and recorders; Weight measuring instruments; Distance and dimension measuring instruments; Speed measuring instruments; Temperature measuring instruments; Electricity measuring instruments; Controllers (regulators); Scientific research and laboratory apparatus, educational apparatus and simulators. Agates; Jet, unwrought or semi-wrought; Amulets [jewellery, jewelry (Am.)]; Anchors [clock- and watchmaking]; Rings [jewellery, jewelry (Am.)]; Spun silver [silver wire]; Silver, unwrought or beaten; Barrels [clock- and watchmaking]; Pendulums [clock- and watchmaking]; Bracelets [jewellery, jewelry (Am.)]; Watchstraps; Busts of precious metal; Watch cases; Clock cases; Watch chains; Chains [jewelry]; Jewelry findings; Jewellery charms; Jewel cases; Necklaces [jewellery]; Chronographs [watches]; Chronoscopes; Stopwatches; Chronoscopes; Diamonds; Tie bars; Figurines of precious metal; Gold thread [jewellery]; Threads of precious metal [jewellery]; Silver thread [jewellery]; Cuff links; Copper tokens; Jewels; Ivory jewelry; Cloisonné jewellery; Jewellery of yellow amber; Badges of precious metal; Iridium; Clock hands; Alloys of precious metal; Ingots of precious metals; Movements for clocks and watches; Medals; Lockets [jewellery]; Precious metals, unwrought or semi-wrought; Watch springs; Coins; Works of art of precious metal; Olivine [gems]; Earrings; Ornaments [jewellery, jewelry (Am.)]; Ornaments of jet; Shoe jewellery; Hat jewellery; Gold, unwrought or beaten; Floor clocks; Atomic clocks; Wristwatches; Watches; Control clocks [master clocks]; Clocks and watches, electric; Osmium; Palladium; Pearls made of ambroid [pressed amber]; Pearls [jewellery]; Beads for making jewelry; Semi-precious stones; Precious stones; Platinum [metal]; Key rings [split rings with trinket or decorative fob]; Jewelry boxes; Clock dials; Sundials; Rhodium; Clockworks; Ruthenium; Boxes of precious metal; Housings for clocks and watches; Jewel cases; Cases for watches [presentation]; Tie pins; Pins being jewelry; Ornamental pins; Brooches [jewellery]; Spinel [precious stones]; Statues of precious metal; Paste jewellery [costume jewelry (Am.)]; Time instruments; Alarm clocks; Watch crystals; Rosaries. Etchings; Aquarelles; Pastes and other adhesives for stationery or household purposes; Franking machines for office use; Franking machines for office use; Scrapbooks; Almanacs; Cigar bands; Hand labelling appliances; Bookbinding apparatus and machines [office equipment]; Vignetting apparatus; Mounting photographs (Apparatus for -); Document laminators for office use; Hand-rests for painters; Modelling clay; Stationery; Bookbinding material; Office requisites; Paper towels; Drawing sets; Stencil cases; Cases for stamps [seals]; Writing cases [stationery]; Atlases; Stickers [stationery]; Ink sticks; Chart pointers, non-electronic; Bibs of paper; Adhesive bands for stationery or household purposes; Gummed tape [stationery]; Table linen of paper; Tickets; Musical greeting cards; Notelets; Pads [stationery]; Sketch pads; Spools for inking ribbons; Binding strips [bookbinding]; Architectural models; Wristbands for the retention of writing instruments; Etching needles; Tracing needles for drawing purposes; Envelopes [stationery]; Inkwells; Tracing patterns; Calendars; Writing board erasers; Song books; Hat boxes of cardboard; Printers' type; Paper; Carbon paper; Copying paper; Silver paper; Wrapping paper; Writing paper; Tracing paper; Wood pulp paper; Filter paper; Hygienic paper; Luminous paper; Waxed paper; Paper for recording machines; Drawer liners of paper, perfumed or not; Electrocardiograph paper; Radiograms (Paper for -); Parchment paper; Xuan paper for Chinese painting and calligraphy; Patterns for making clothes; Patterns for dressmaking; Papier mâché; Cards; Geographical maps; Desk pads; Folders for papers; Signboards of paper or cardboard; Placards of paper or cardboard; Posters; Postcards; Paperboard; Wood pulp board [stationery]; Perforated cards for Jacquard looms; Catalogues; Tags for index cards; Painters' easels; Place mats of paper; Sealing wax; Numbers [type]; Rollers for typewriters; Newsletters; Files [office requisites]; Electrotypes; Printing blocks; Pen clips; Stationery (Cabinets for -) [office requisites]; Starch paste [adhesive] for stationery or household purposes; Pastes and other adhesives for stationery or household purposes; Manifolds [stationery]; Compasses for drawing; Composing sticks; Wrappers [stationery]; Covers of paper for flower pots; Chromos; Rub down transfers; Diagrams; Drawings; Dispensers (Adhesive tape -) [office requisites]; Finger-stalls [office requisites]; Duplicators; Elastic bands for offices; Labels of paper or cardboard; Marker pens; Paper tissues; Printers' blankets, not of textile; Page holders; Paperweights; Staples for offices; Figurines [statuettes] of papier mâché; Cords for bookbinding; Filters (Paper coffee -); Paper bows; Bubble packs (Plastic -) for wrapping or packaging; Absorbent sheets of paper or plastic for foodstuff packaging; Paper sheets [stationery]; Sheets of reclaimed cellulose for wrapping; Viscose sheets for wrapping; Humidity control sheets of paper or plastic for foodstuff packaging; Drawing materials; Writing materials; School supplies [stationery]; Photographs [printed]; Photo-engravings; Stamps; Comic books; Punches [office requisites]; Flags of paper; Paper clasps; Marking chalk; Tailors' chalk; Writing chalk; Chalk for lithography; Newspapers; Pastes and other adhesives for stationery or household purposes; Pastes and other adhesives for stationery or household purposes; Rubber erasers; Paper-clips; Bottle wrappers of paper or cardboard; Pictures; Ink; Indian inks; Correcting ink [heliography]; Bottle envelopes of paper or cardboard; Isinglass for stationery or household purposes; Engraving plates; Address plates for addressing machines; Blackboards; Writing slates; Printed matter; Steel letters; Letters [type]; Booklets; Books; Printers' reglets; Correcting fluids [office requisites]; Lithographs; Typewriters; Envelope sealing machines, for offices; Stapling presses [office requisites]; Sealing machines for offices; Addressing machines; Pencil sharpening machines, electric or non-electric; Manuals [handbooks]; Globes; Stencils [stationery]; Stencil plates; Erasing shields; Teaching materials [except apparatus]; Packaging material made of starches; Modelling materials; Filter materials of paper; Sealing compounds for stationery purposes; Plastics for modelling; Pencils; Charcoal pencils; Slate pencils; Stencils; Pencil leads; Handwriting specimens for copying; Embroidery designs [patterns]; Forms, printed; Adhesive tapes for stationery or household purposes; Self-adhesive tapes for stationery or household purposes; Correcting tapes [office requisites]; Paper ribbons; Inking ribbons for computer printers; Ink ribbons; Typewriter ribbons; Pen wipers; Numbering apparatus; Engravings; Lithographic works of art; Oleographs; Pamphlets; Printed timetables; Sealing wafers; Pantographs [drawing instruments]; Announcement cards [stationery]; Modelling paste; Pastel crayons; Plastic sheets for packaging; Plastic cling film, extensible, for palletization; Pens [office requisites]; Nibs; Nibs of gold; Paint brushes; Writing brushes; Paint brushes; Steel pens; Office perforators; Periodicals; Graining combs; Blueprints; Watercolor saucers (Artists' -); Cream containers of paper; Folders [stationery]; Lithographic stones; Inkstones; Money holders; Paintings [pictures], framed or unframed; Advertisement boards of paper or cardboard; Pencil holders; Pencil lead holders; Penholders; Checkbook covers; Document holders [stationery]; Chalk holders; Passport covers; Pen boxes; Credit card imprinters, non-electric; Erasing products; Prospectuses; Printed publications; Printed publications; Push pins; Writing or drawing books; Square rulers; Display binders; Document files [stationery]; Graphic representations; Scrapers [erasers] for offices; Bookends; Ledgers [books]; Indexes; T-squares for drawing; Drafting rulers; Book binders; Graphic reproductions; Portraits; Magazines [periodicals]; House painters' rollers; Bags [envelopes, pouches] of paper or plastics, for packaging; Conical paper bags; Bags for microwave cooking; Garbage bags of paper or of plastics; Facial tissues of paper; Boxes of cardboard or paper; Paint boxes; File cards; Bookmarkers; Writing cases [sets]; Printing sets, portable [office requisites]; Place mats of paper; Biological samples for use in microscopy [teaching materials]; Histological sections for teaching purposes; Balls for ball-point pens; Seals [stamps]; Shields [paper seals]; Stands for pens and pencils; Mats for beer glasses; Coasters of paper; Squares for drawing; Modelling clays (Moulds for -) [artists' materials]; Steatite [tailor's chalk]; Fountain pens; Fabrics for bookbinding; Paper tapes and cards for the recordal of computer programmes; Drawing instruments; Writing instruments; French curves; Photograph stands; Stamp stands; Holders for stamps [seals]; Notebooks; Paper cutters [office requisites]; Blotting paper; Stamp pads; Ink pads; Typewriter keys; Calculating tables; Drawing boards; Prints [engravings]; Clipboards; Palettes for painters; Tracing cloth; Cloth for bookbinding; Composing frames [printing]; Inking sheets for document reproducing machines; Inking sheets for duplicators; Gummed cloth for stationery purposes; Canvas for painting; Pencil sharpeners, electric or non-electric; Trading cards, other than for games; Stamps [seals]; Address stamps; Sealing stamps; Drawing pens; Tablecloths of paper; Table napkins of paper; Tissues of paper for removing make-up; Transparencies [stationery]; Paper shredders for office use; Cardboard tubes; Moisteners for gummed surfaces [office requisites]; Moisteners [office requisites]; Galley racks [printing]; Paint trays; Trays for sorting and counting money; Flyers; Desk trays; Hectographs; Modelling wax, not for dental purposes; Mimeograph apparatus and machines. Umbrella rings; Saddle trees; Saddlery; Key cases; Fastenings for saddles; Leather shoulder belts; Animal harnesses; Alpenstocks; Walking sticks; Umbrella sticks; Vanity cases, not fitted; Trunks [luggage]; Traveling trunks; Casual bags; Slings for carrying infants; Sport bags; Chain mesh purses; Tool bags of leather, empty; Purses; Handbags; Travelling sets [leatherware]; Horse bridles; Bridoons; Straps for soldiers' equipment; Kid; Bags (Game -) [hunting accessories]; Briefbags; Satchels; Leatherboard; Cases of leather or leatherboard; Head-stalls; Straps (Leather -); Collars for animals; Horse collars; Horse blankets; Laces (Leather -); Leather straps; Straps of leather [saddlery]; Harness straps; Straps for skates; Leather, unworked or semi-worked; Horseshoes; Leather thread; Moleskin [imitation of leather]; Umbrella covers; Whips; Knee-pads for horses; Casings, of leather, for springs; Covers for horse saddles; Pads for horse saddles; Trimmings of leather for furniture; Harness fittings; Leather leashes; Imitation leather; Walking cane handles; Umbrella handles; Suitcase handles; Pouch baby carriers; Pouch baby carriers; Cat o' nine tails; Chin straps, of leather; Bits for animals [harness]; Muzzles; Parasols; Blinkers [harness]; Umbrellas; Animal skins, hides; Cattle skins; Curried skins; Skins of chamois, other than for cleaning purposes; Fur; Skin (Goldbeaters' -); Rubber parts for stirrups; Credit card cases [wallets]; Card cases [notecases]; Music cases; Wallets; Reins; Net bags for shopping; Furniture coverings of leather; Haversacks; Feed bags for animals; Bags [envelopes, pouches] of leather, for packaging; Bags for campers; Beach bags; Sport bags; Travelling bags; Bags for climbers; Boxes of leather or leatherboard; Boxes of vulcanised fibre; Hat boxes of leather; Butts [parts of hides]; Walking stick seats; Riding saddles; Stirrups; Stirrup leathers; Umbrella or parasol ribs; Frames for umbrellas or parasols; Handbag frames; Traces [harness]; Valises; Attaché cases; Attaché cases; Garment bags for travel; Valves of leather; Backpacks. Bed fittings, not of metal; Furniture fittings, not of metal; Door fittings, not of metal; Beehives; Plate racks; Yellow amber; Curtain rings; Stuffed animals; Head-rests [furniture]; Cupboards; Medicine cabinets; Claws (Animal -); Hand-held flagpoles, not of metal; Coatstands; Ivory, unworked or semi-worked; Winding spools, not of metal, non-mechanical, for flexible hoses; Poles for curtains; Picture rods; Whalebone, unworked or semi-worked; Bamboo; Workbenches; Benches [furniture]; Saw benches [furniture]; Counters [tables]; Coffins; Barrels, not of metal; Ambroid bars; Door knockers, not of metal; Chests, not of metal; Reels of wood for yarn, silk, cord; Non-mechanical reels, not of metal, for flexible hoses; Curtain tie-backs; Casks, not of metal; Identification bracelets, not of metal; Sideboards; Dinner wagons; Bolts, not of metal; Busts of wood, wax, plaster or plastic; Costume stands; Door bells, not of metal, non-electric; Settees; Kennels; Reeds [plaiting materials]; Taps, not of metal, for casks; Bolsters; Non-metal bottle caps; Sealing caps, not of metal; Trolleys [furniture]; Infant walkers; Plastic key cards, not encoded and not magnetic; Placards of wood or plastics; Index cabinets; Chests for toys; Letter boxes, not of metal or masonry; Lockers; Chests of drawers; Trestles [furniture]; Saw horses; Waxcomb for beehives; Barrel hoops, not of metal; Hinges, not of metal; Hampers [baskets] for the transport of items; Baskets, non-metallic; Bottle closures, not of metal; Closures for containers, non-metallic; Plugs, not of metal; Mobiles [decoration]; Shells; Oyster shells; Floating containers, not of metal; Containers, not of metal [storage, transport]; Coral; Animal horns; Stag antlers; Picture frames; Horn, unworked or semi-worked; Corozo; Tea carts; Kennels for household pets; Bassinets; Cushions; Air cushions, not for medical purposes; Pet cushions; Covers for clothing [wardrobe]; Covers (Garment -) [storage]; Nuts, not of metal; Decorations of plastic for foodstuffs; Meat safes; Towel dispensers, fixed, not of metal; Divans; Staves of wood; Display racks; Newspaper display stands; Curtain holders, not of textile material; Baby changing platforms; Baby changing platforms; Honeycombs; Stair rods; Plaster statues; Figurines made of wood; Statuettes of bone; Statuettes made of ivory; Figurines made of gypsum derivatives; Edgings of plastic for furniture; Casks of wood for decanting wine; Crates; Nesting boxes; Hooks, not of metal, for clothes rails; Clothes hooks, not of metal; Curtain hooks; Mooring buoys, non-metallic; Beds for pets; Flower stands; Rattan; Plaited straw, except matting; Clothes hangers and clothes hooks; Pillows; Air pillows, not for medical purposes; Window fittings, not of metal; Coffin fittings, not of metal; Bottle casings of wood; Imitation tortoiseshell; Cask stands, not of metal; Stands for calculating machines; Signboards of wood or plastics; Mirror tiles; Cabinet work; Lecterns; Scratching posts for cats; Beds; Hospital beds; Hydrostatic beds, not for medical purposes; Mother-of-pearl, unworked or semi-worked; Mannequins and tailors' dummies; Door handles, not of metal; Mattresses; Air mattresses, not for medical purposes; Changing mats; Bedding, except linen; Inflatable furniture; Furniture of metal; Office furniture; Furniture; School furniture; Picture frame moldings; Brush mountings; Vice benches [furniture]; Wood ribbon; Straw edgings; Nesting boxes for household pets; House numbers, not of metal, non-luminous; Works of art of wood, wax, plaster or plastic; Wickerwork; Inflatable publicity objects; Wind chimes [decoration]; Mattress (Straw -); Shoulder poles [yokes]; Handling pallets, not of metal; Transport pallets, not of metal; Baskets, non-metallic; Fishing baskets; Keyboards for hanging keys; Furniture partitions of wood; Fireguards; Screens [furniture]; Pegs [pins], not of metal; Poles, not of metal; Table tops; Non-metal dog tags; Loading pallets, not of metal; Tent pegs, not of metal; Flower-pot pedestals; Ambroid plates; Armchairs; Hairdressers' chairs; Knobs, not of metal; Towel stands [furniture]; Hat stands; Reading easels; Umbrella stands; Magazine racks; Bottle racks; Doors for furniture; Pulleys of plastics for blinds; Writing desks; Writing desks; Fodder racks; Gun racks; Playpens; Packaging containers of plastic; Containers, not of metal, for liquid fuel; Mattresses; Furniture shelves; Shelves for storage; Library shelves; Shelves for filing-cabinets [furniture]; Mats, removable, for sinks; Rivets, not of metal; Support rails for curtains; Rollers [casters], not of metal; Bed casters, not of metal; Curtain rollers; Loading gauge rods, not of metal, for railway waggons [wagons]; Latches, not of metal; Racks; Filing cabinets; Ladders of wood or plastics; Boarding stairs, not of metal, mobile, for passengers; Steps [ladders], not of metal; Step stools, not of metal; Boxes of wood or plastic; Writing desks; Writing desks; Sun loungers; Seats; Seats of metal; High chairs for babies; Reservoirs, not of metal nor of masonry; Non-metal cable clips; Locks, other than electric, not of metal; Non-metal door bolts; Locks, not of metal, for vehicles; Stools; Sofas; Stakes, not of metal, for plants or trees; Mirrors (silvered glass); Hand-held mirrors [toilet mirrors]; Meerschaum; Clothes hangers and clothes hooks; Bakers' bread baskets; Statues of wood, wax, plaster or plastic; Fixing plugs, not of metal; Indoor window blinds [shades] [furniture]; Mats for infant playpens; Screw tops, not of metal, for bottles; Corks for bottles; Corks; Numberplates, not of metal; Tortoiseshell; Tables; Shelves for typewriters; Drafting tables; Dressing tables; Tables of metal; Massage tables; Washstands [furniture]; Trolleys for computers [furniture]; Sections of wood for beehives; Embroidery frames; Wood bedsteads; Bamboo curtains; Bead curtains for decoration; Interior textile window blinds; Freestanding partitions [furniture]; Deck chairs; Straw plaits; Chopping blocks [tables]; Troughs, not of metal, for mixing mortar; Birds (Stuffed -); Funerary urns; Water-pipe valves of plastic; Drains [valves] made of plastic; Valves, not of metal, other than parts of machines; Vats, not of metal; Trays, not of metal; Slatted indoor blinds; Fans for personal use, non-electric; Showcases; Glass (Silvered -) [mirrors]; Screws, not of metal; Animal hooves. Drinking troughs; Fly swatters; Indoor aquaria; Shoe trees; Shoe trees; Glove stretchers; Cruets; Glass vials [receptacles]; Rails and rings for towels; Poultry rings; Napkin rings; Rings for birds; Deodorising apparatus for personal use; Polishing apparatus and machines, for household purposes, non-electric; Make-up removing appliances; Noodle machines, hand-operated; Aerosol dispensers, not for medical purposes; Bottle openers, electric and non-electric; Brush goods; Pipettes [wine-tasters]; Bread boards; Washing boards; Cutting boards for the kitchen; Basins [bowls]; Bird baths; Basins [receptacles]; Cocktail stirrers; Chopsticks; Cooking pot sets; Carpet beaters [hand instruments]; Beaters, non-electric; Pouring spouts; Beer mugs; Beverage glassware; Cups of paper or plastic; Tankards; Jars (Glass -) [carboys]; Glass bowls; Tea infusers; Boxes for sweetmeats; Drinking bottles; Isothermic bags; Bottles; Glass flasks [containers]; Insulating flasks; Refrigerating bottles; Pitchers; Butter dishes; Busts of china, terra-cotta or glass; Coffeepots, non-electric; Mugs; Shoe horns; Butter-dish covers; Candlesticks; Candlesticks; Fabrics (Buckets made of woven -); Straws for drinking; Jars; Lazy susans; Cotton waste for cleaning; Wool waste for cleaning; Saucepans; Boot jacks; Corkscrews, electric and non-electric; Furniture dusters; Epergnes; Bread baskets for household purposes; Baskets for household purposes; Waste paper baskets; Closures for pot lids; Shakers; Strainers; Tea strainers; Confectioners' decorating bags [pastry bags]; Aquarium hoods; Covers for dishes; Pot lids; Ironing board covers, shaped; Fruit cups; Cheese-dish covers; Tea cosies; Covers, not of paper, for flower pots; Horns (Drinking -); Plate glass [raw material]; Crystal [glassware]; Cinder sifters for household purposes; Sifters [household utensils]; Mixing spoons [kitchen utensils]; Kettles, non-electric; Abrasive pads for kitchen purposes; Comb cases; Demijohns; Attracting and killing insects (Electric devices for -); Attracting and killing insects (Electric devices for -); Tie presses; Toilet roll dispensers; Soap dispensers; Water apparatus for cleaning teeth and gums; Blenders, non-electric, for household purposes; Earthenware; Hip flasks; Vitreous silica fibers [fibres], not for textile use; Fibreglass, other than for insulation or textile use; Figurines [statuettes] of porcelain, ceramic, earthenware or glass; Fibreglass thread, not for textile use; Floss for dental purposes; Coffee filters, non-electric; Tea strainers; Strainers for household use; Window-boxes; Flasks; Deep fryers, non-electric; Whisks, non-electric, for household purposes; Smoke absorbers for household purposes; Cages for household pets; Buttonhooks; Mess-tins; Portable cool boxes, non-electric; China ornaments; Griddles [cooking utensils]; Kitchen graters; Gardening gloves; Polishing gloves; Gloves for household purposes; Trays of paper, for household purposes; Trays for household purposes; Funnels; Watering cans; Sprinklers; Salad bowls; Signboards of porcelain or glass; Steel wool for cleaning; Glass wool, other than for insulation; Tar-brushes, long handled; Nozzles for watering hose; Dripping pans; Vegetable dishes; Wax-polishing (Apparatus for -), non-electric; Wax-polishing appliances, non-electric, for shoes; Coffee percolators, non-electric; Pepper mills, hand-operated; Coffee grinders, hand-operated; Majolica; Mangers for animals; Cooking pots; Autoclaves, non-electric, for cooking; Feeding troughs; Polishing materials for making shiny, except preparations, paper and stone; Material for brush-making; Rolling pins, domestic; Basting spoons [cooking utensils]; Clothes-pegs; Mosaics of glass, not for building; Mills for household purposes, hand-operated; Toilet cases; Picnic baskets (Fitted -), including dishes; Nest eggs, artificial; Works of art, of porcelain, terra-cotta or glass; Opaline glass; Cauldrons; Scoops for household purposes; Tart scoops; Cleaning rags; Dustbins; Hair for brushes; Polishing leather; Skins of chamois for cleaning; Shaving brushes; Hot pots, not electrically heated; Pepper pots; Combs; Comb (electric); Combs for animals; Combs for the hair (Large-toothed -); Plates to prevent milk boiling over; Plates; Serving platters; Paper plates; Disposable table plates; Saucers; Candle rings; Feather brooms; Powder puffs; Porcelain ware; Knife rests for the table; Menu card holders; Stands for shaving brushes; Soap dishes; Sponge holders; Toothpick holders; Table napkin holders; Cosmetic powder compacts; Toilet roll holders; Egg cups; Fruit presses, non-electric, for household purposes; Ceramics for household purposes; Crumb trays; Pastry cutters; Heat-insulated containers; Heat-insulated containers for beverages; Drinking vessels; Lunch boxes; Bread bins; Containers for household or kitchen use; Kitchen containers; Thermally insulated containers for food; Portable cool boxes, non-electric; Salt shakers; Non-metal coin banks; Heaters for feeding bottles, non-electric; Boxes of glass; Cookie jars; Tea caddies; Boxes for dispensing paper towels; Soap boxes; Brooms; Mops; Carpet sweepers; Buckets; Ice buckets; Coffee services [tableware]; Liqueur sets; Tea services [tableware]; Spice sets; Services [dishes]; Oil cruets; Sieves [household utensils]; Bristles (Animal -) [brushware]; Siphon bottles for carbonated water; Silica (Fused -) [semi-worked product], other than for building; Vessels of metal for making ices and iced drinks; Coasters, not of paper or textile; Trivets [table utensils]; Cosmetic spatulas; Spatulas for kitchen use; Brushes; Brushes (Electric -), except parts of machines; Boot brushes; Horse brushes; Dishwashing brushes; Brushes for cleaning tanks and containers; Eyebrow brushes; Toilet brushes; Lamp-glass brushes; Toothbrushes; Toothbrushes, electric; Nail brushes; Scrubbing brushes; Candle extinguishers; Pins of metal (Cooking -); Dusting apparatus, non-electric; Presses (Garlic -) [kitchen utensils]; Sprinklers for watering flowers and plants; Toilet sponges; Sponges for household purposes; Abrasive sponges for scrubbing the skin; Cake moulds; Waffle irons, non-electric; Ice cube molds; Cookery molds [moulds]; Moulds [kitchen utensils]; Statues of porcelain, ceramic, earthenware or glass; Figurines [statuettes] of porcelain, ceramic, earthenware or glass; Laundry drying racks; Trouser presses; Cleaning tow; Currycombs; Mop wringers; Cloth for washing floors; Dusting cloths; Sprinkling devices; Cleaning instruments, hand-operated; Plungers for clearing blocked drains; Toothpicks; Gridiron supports; Flat-iron stands; Holders for flowers and plants [flower arranging]; Cookie [biscuit] cutters; Metal scouring pads; Pads for cleaning; Baking mats; Glass stoppers; Ironing boards; Cups; Saucepans (Earthenware -); Teapots; Stretchers for clothing; Terrariums (Indoor -) [plant cultivation]; Terrariums (Indoor -) [vivariums]; Watering can sprinklers; Washtubs; Washtubs; Insect traps; Fly catchers [traps or whisks]; Rat traps; Mouse traps; Kitchen grinders, non-electric; Birdcages; Urns; Cosmetic utensils; Cooking utensils, non-electric; Kitchen utensils; Household utensils; Toilet utensils; Perfume vaporizers; Litter boxes for pets; Baby baths, portable; Tableware, other than knives, forks and spoons; Pottery; Pots; Vases; Flower pots; Chamber pots; Perfume burners; Glue-pots; Cabarets [trays]; Opal glass; Glasses [receptacles]; Painted glassware; Glass incorporating fine electrical conductors; Glass, unworked or semi-worked, except building glass; Powdered glass for decoration; Unfinished glass for vehicle windows; Enamelled glass; Sugar bowls; Soup bowls; Broom handles, not of metal. Rainproof clothing; Clothing of imitations of leather; Leather clothing; Motorists' clothing; Cyclists' clothing; Clothing for gymnastics; Gowns; Suits; Pinafore dresses; Bathrobes; Non-slipping devices for footwear; Clothing; Bandanas [neckerchiefs]; Bibs, not of paper; Bonnets; Berets; Underwear; Sweat-absorbent underwear; Boas [necklets]; Teddies [underclothing]; Suspenders; Corsets; Goloshes; Skull caps; Footwear; Training shoes; Stockings; Sweat-absorbent stockings; Socks; Breeches; Swimming trunks; Shirts; Short-sleeve shirts; Bodices [lingerie]; Sports singlets; Hats; Top hats; Hats (Paper -) [clothing]; Coats; Hoods [clothing]; Frames (Hat -) [skeletons]; Stuff jackets [clothing]; Chasubles; Belts [clothing]; Belts (Money -) [clothing]; Tights; Shoulder wraps; Detachable collars; Camisoles; Headgear; Layettes [clothing]; Corselets; Swimming costumes; Masquerade costumes; Beachwear; Neckties; Ascots; Bathing caps; Shower caps; Knickers; Headbands [clothing]; Pocket squares; Fittings of metal for footwear; Linings (Ready-made -) [parts of clothing]; Scarves; Gabardines [clothing]; Boot uppers; Gaiters; Jackets [clothing]; Garters; Fishing vests; Stuff jackets [clothing]; Fishermen's jackets; Skirts; Aprons [clothing]; Pinafore dresses; Aprons [clothing]; Girdles; Mittens; Gloves [clothing]; Ski gloves; Welts for footwear; Ready-to-wear clothing; Paper clothing; Knitwear [clothing]; Jumpers; Leg warmers; Leggings [trousers]; Liveries; Jumpers; Hosiery; Sweaters; Sweaters; Muffs [clothing]; Maniples; Pelerines; Mantillas; Sleep masks; Skorts; Miters [hats]; Boxer shorts; Babies' pants [clothing]; Briefs; Wetsuits for water-skiing; Waistcoats; Trousers; Mules; Ear muffs [clothing]; Parkas; Pelisses; Furs [clothing]; Shirt yokes; Pyjamas; Cuffs; Ponchos; Sweaters; Tips for footwear; Stocking suspenders; Sock suspenders; Brassieres; Heelpieces for stockings; Sandals; Bath sandals; Saris; Sarongs; Leg warmers; Footmuffs, not electrically heated; Shoes; Espadrilles; Bath slippers; Gymnastic shoes; Beach shoes; Football boots; Training shoes; Ski boots; Shawls; Sashes for wear; Wimples; Insoles; Topcoats; Outerclothing; Dress shields; Knee-high stockings; Petticoats; Slips [underclothing]; Shirt fronts; Half-boots; Lace boots; Boots; Fur stoles; Footwear soles; Studs for football boots; Heels; Heelpieces for footwear; Pockets for clothing; Tee-shirts; Togas; Footwear uppers; Turbans; Combinations [clothing]; Uniforms; Veils [clothing]; Robes; Cap peaks; Sun visors [headwear]; Visors (headgear); Wooden shoes. Needles; Shoemakers' needles; Sewing needles; Needles for wool combing machines; Darning needles; Binding needles; Saddlers' needles; Appliqués [haberdashery]; Decorative articles for the hair; Haberdashery, except thread; Needle cases; False moustaches; False beards; Curlpapers; Hair curlers; Darning lasts; Edgings for clothing; Buttons; Stud buttons; Brassards; Armband for holding sleeves; Brassards; False hair; Human hair; Needle cases; Bows for the hair; Zippers; Zippers for bags; Dress fastenings; Numerals for marking linen; Numerals for marking linen; Chenille [passementerie]; Rosettes [haberdashery]; Cords for clothing; Cords for trimming; Woollen laces; Braids; Artificial flower wreaths; Hair colouring caps; Needle cushions; Pin cushions; Badges for wear, not of precious metal; Badges [buttons] (Ornamental novelty -); Sewing thimbles; Hair extensions; Hook and pile fastening tapes; Hair bands; Belt clasps; Bobby pins; Fastenings for suspenders; Knitting needles; Festoons [embroidery]; Buckles [clothing accessories]; Shoe fasteners; Dress body fasteners; Shoe buckles; False hems; Top-knots [pompoms]; Artificial flowers; Curling pins; Fringes; Embroidery; Artificial fruit; Frills for clothing; Lace for edgings; Hooks [haberdashery]; Hooks for corsets; Shoe hooks; Artificial garlands; Bodkins; Numerals for marking linen; Orsedew [trimmings for clothing]; Trouser clips for cyclists; Tassels [haberdashery]; Elastic ribbons; Ribbons [haberdashery]; Prize ribbons; Tapes for curtain headings; Shoe eyelets; Eyelets for clothing; Shoe trimmings; Hat trimmings; Spangles for clothing; Wigs; Lace trimmings; Birds' feathers [clothing accessories]; Beads, other than for making jewelry; Competitors' numbers; Heat adhesive patches for repairing textile articles; Heat adhesive patches for decoration of textile articles; Artificial plants; Feathers [clothing accessories]; Ostrich feathers [clothing accessories]; Hair nets; Silver embroidery; Gold embroidery; Bobbins for retaining embroidery floss or wool [not parts of machines]; Mica spangles; Sewing boxes; Picot [lace]; Trimmings for clothing; Shoulder pads for clothing; Brooches [clothing accessories]; Pins, other than jewellery [jewelry (Am.)]; Hair pins; Shuttles for making fishing nets; Whalebones for corsets; Collar supports; Shoe laces; Toupees; Tresses of hair; Frills [lacework]; Crochet hooks; Rug hooks; Skirt flounces. Lighters for smokers; Pocket machines for rolling cigarettes; Cigarette holders; Cigar holders; Tobacco pouches; Absorbent paper for tobacco pipes; Cigarette paper; Cigarillos; Cigar cases; Herbs for smoking; Matches; Cigarette filters; Pipe cleaners for tobacco pipes; Firestones; Pipes; Ashtrays; Match holders; Tips of yellow amber for cigar and cigarette holders; Tips of yellow amber for cigar and cigarette holders; Cigarette tips; Mouthpieces for cigarette holders; Books of cigarette papers; Pipe racks for tobacco pipes; Matchboxes; Cigarette cases; Humidors; Gas containers for cigar lighters; Cigarettes; Cigarettes containing tobacco substitutes, not for medical purposes; Electronic cigarettes; Cigars; Spittoons for tobacco users; Snuff boxes; Tobacco; Chewing tobacco; Snuff; Cigar cutters; Tobacco jars. Bill-posting; Rental of vending machines; Rental of advertising time on communication media; Commercial information agencies; Advertising agencies; Import-export agency services; Updating of advertising material; Updating and maintenance of data in computer databases; Shop window dressing; Commercial administration of the licensing of the goods and services of others; Cost price analysis; Commercial or industrial management assistance; Assistance in management of business activities; Personnel management consulting; Business management consulting; Professional business consulting; Accounting; Dissemination of advertisements; Demonstration of goods; Business management of performing artists; Distribution of samples for publicity purposes; Direct mail advertising; Compilation of statistics; Invoicing; Provision of commercial and business contact information; Business management of hotels; Business management of sports people; Business management for freelance service providers; Computerized file management; Providing business information via a web site; Business information; Consumers (Commercial information and advice for -) [consumer advice shop]; Business investigation; Layout services for advertising purposes; Rental of advertising space; Marketing services; Negotiation and conclusion of commercial transactions for third parties; Rental of photocopying machines; Office machines and equipment rental; Publicity material rental; Rental of sales stands; Organization of exhibitions for commercial or advertising purposes; Organisation of trade fairs for commercial or advertising purposes; Fashion shows for promotional purposes (Organization of -); Web site traffic optimization; Search engine optimisation; Efficiency experts; Payroll preparation; Presentation of goods on communication media, for retail purposes; Economic forecasting; Production of advertising films; Sales promotion for others; Publication of publicity texts; Advertising; Advertising, including on-line advertising on a computer network; Advertising by mail order; Radio advertising; Television advertising; Compilation of information into computer databases; Business inquiries; Personnel recruitment; Writing of publicity texts; Public relations services; Sponsorship search; Data search in computer files for others; Conducting of marketing studies; Marketing studies; Business research; Document reproduction; Personnel selection using psychological testing; Arranging newspaper subscriptions for others; Arranging subscriptions to telecommunication services for others; Procurement services for third parties (acquisition of goods and services for other companies); Price comparison services; Consultancy regarding business organisation and business economics; Advisory services for business management; Business organisation consulting; Typing services; Photocopying services; Business project management services for construction projects; Modelling for advertising or sales promotion; Commercial intermediation services; News clipping services; Relocation services for businesses; Telephone answering for unavailable subscribers; Secretarial services; Shorthand; Outsourcing services [business assistance]; Telemarketing services; Retail or wholesale services for pharmaceutical, veterinary and sanitary preparations and medical supplies; Pay per click advertising; Opinion polling; Tax preparation; Drawing up statements of account; Transcription of communications [office functions]; Administrative processing of purchase orders; Word processing; Employment agencies; Business appraisal; Auctioneering services; Business auditing. News agencies; Providing telecommunications connections to a global computer network; Communications by fibre optic networks; Radio communications; Communications by telephone; Communication by telegram; Communications by computer terminals; Television broadcasting; Providing access to databases; Providing user access to global computer networks; Providing telecommunication channels for teleshopping services; Providing internet chatrooms; Provision of on-line forums; Information about telecommunication; Electronic messaging; Rental of access time to global computer networks; Rental of telecommunication equipment; Rental of message sending apparatus; Rental of facsimile apparatus; Rental of modems; Rental of telephones; Communications by cellular phones; Paging services [radio, telephone or other means of electronic communication]; Wireless broadcasting; Telecommunications routing and junction services; Electronic bulletin board services [telecommunications services]; Voice mail services; Teleconferencing services; Providing video conferencing services; Telephone services; Telegraph services; Telex services; Cable television broadcasting; Transmission of greeting cards online; Transmission of digital files; Message sending; Computer-aided transmission of messages and images; Facsimile transmission; Telegram transmission; Transmission of greeting cards online; Satellite transmission. Academies [education]; Animal training; Rental of movie projectors and accessories; Rental of show scenery; Rental of stage scenery; Rental of tennis courts; Rental of motion pictures; Rental of sound recordings; Coaching [training]; Sport camp services; Casino facilities [gambling] (Providing -); Circuses; Boarding schools; Music composition services; Boarding schools; Conducting fitness classes; Timing of sports events; Entertainment; Radio entertainment; Television entertainment; Dubbing; Education; Religious education; Educational examination; Practical training [demonstration]; Golf facilities (Providing -); Photography; Recreation information; Education information; Entertainment information; Gymnastic instruction; Correspondence courses; Sign language interpretation; Tuition; Layout services, other than for advertising purposes; Night club services [entertainment]; Night club services [entertainment]; Providing karaoke services; Providing sports facilities; Microfilming; Production of television and radio programs; Videotape editing; Music-halls; Rental of audio equipment; Rental of lighting apparatus for theatrical sets or television studios; Rental of radio and television sets; Games equipment rental; Rental of sports equipment, except vehicles; Rental of skin diving equipment; Rental of toys; Rental of sports grounds; Rental of video recorders; Rental of stadium facilities; Rental of video cameras; Rental of videotapes; Organization of balls; Organisation of sports competitions; Arranging of beauty contests; Organisation of competitions [education or entertainment]; Organization of exhibitions for cultural or educational purposes; Operating of lotteries; Organization of fashion shows for entertainment purposes; Organization of shows [impresario services]; Arranging and conducting of congresses; Arranging and conducting of colloquiums; Arranging and conducting of symposiums; Arranging and conducting of conferences; Arranging and conducting of seminars; Arranging and conducting of concerts; Workshops (Arranging and conducting of -) [training]; Vocational guidance [education or training advice]; Amusement park services; Planning (Party -) [entertainment]; Booking of seats for shows; Rental of books; Film production, other than advertising films; Film production, other than advertising films; Production of music; Production of shows; Cinema presentations; Publication of books; Publication of texts, other than publicity texts; Electronic text publishing services; On-line publication of electronic books and journals (non-downloadable); Publication of printed matter in electronic form; Publication of periodicals and books in electronic form; On-line publication of electronic books and journals (non-downloadable); Electronic online publication of periodicals and books; Publishing by electronic means; Performances (Presentation of live -); Theater productions; Scriptwriting services; Writing of texts, other than publicity texts; Videotaping; Photographic reporting; Vocational retraining; Nursery schools; Modelling for artists; Entertainer services; Mobile library services; Ticket agency services [entertainment]; Calligraphy services; Camp services (Holiday -) [entertainment]; Health club services [health and fitness training]; Club services [entertainment or education]; News reporters services; Disc jockey services; Discotheque services; Recreation facilities (Providing -); Zoological garden services; Online games (originating from a computer network); Language interpreter services; Museum facilities (Providing -) [presentation, exhibitions]; Orchestra services; Personal trainer services [fitness training]; Amusement arcade services; Recording studios; Translation and interpretation; Educational services provided by schools; Subtitling; Movie studios; Tutoring. Updating of computer software; Land surveying; Chemical analysis; Handwriting analysis [graphology]; Water analysis; Computer system analysis; Architecture; Electronic data storage; Authenticating works of art; Cloud computing; Material testing; Architectural consultation; Consultancy in the field of energy-saving; Computer software consultancy; Consultancy in the design and development of computer hardware; Web site design consultancy; Oil-well testing; Quality control; Testing [inspection] of vehicles for roadworthiness; Conversion of computer programs and data, other than physical conversion; Conversion of data or documents from physical to electronic media; Creating and maintaining web sites for others; Design of interior decor; Digitization of documents [scanning]; Industrial design; Duplicating computer programs; Computer software design; Oil-field surveys; Underwater exploration; Provision of scientific information, advice and consultancy in relation to carbon offsetting; Providing information on computer technology and programming via a web site; Providing search engines for the internet; Engineering services; Cloud seeding; Installation of software; Rental of software; Maintenance of software; Monitoring of computer systems by remote access; Computer rental; Rental of web servers; Hosting computer sites; Geological surveys; Surveying; Urban planning; Computer system design; Construction drafting; Computer programming; Geological prospecting; Clinical trials; Textile testing; Recovery of computer data; Oil prospecting; Research and development for others; Biological research; Geological research; Bacteriological research; Chemical research; Cosmetic research; Physics [research]; Physics research; Research in the field of environmental protection; Mechanical research; Scientific research; Technical research relating to computers; Preparation of reports relating to technical research; Off-site data backup; Server hosting; Analysis for oil-field exploitation; Meteorological information; Analysis for oil-field exploitation; Mapping services; Chemist services; Information technology [IT] consultancy; Graphic art design; Packaging design; Laboratory (Scientific -) services; Computer virus protection services; Software as a service [SaaS]; Dress designing; Styling [industrial design]; Conducting technical project studies; Calibration [measuring]; Quality evaluation of standing timber; Evaluation of wool (Quality -); Quality evaluation of standing timber; Energy auditing. Accommodation bureaux [hotels, boarding houses]; Day-nurseries [crèches]; Café services; Café services; Retirement homes; Tourist homes; Providing campground facilities; Rental of temporary accommodation; Canteens; Rental of lighting apparatus; Rental of cooking apparatus; Rental of portable buildings; Rental of drinking water dispensers; Rental of meeting rooms; Rental of chairs, tables, table linen, glassware; Rental of tents; Pet boarding services; Boarding houses; Hotel reservations; Temporary accommodation reservations; Boarding house bookings; Restaurants; Self-service restaurant services; Food sculpting; Hotel services; Bar services; Holiday camp services [lodging]; Catering for the provision of food and beverages; Motels; Snack-bars. Farming (animals); Landscape design; Dentistry; Animal healthcare services; Public baths for hygiene purposes; Turkish baths; Nursing home services; Convalescent home services; Chiropractics; Tree surgery; Plastic surgery; Medical clinic services; Floral design; Wreath making; Pharmacy advice; Advisory services relating to health; Depilatory waxing; Rehabilitation of substance abuse patients; Vermin exterminating for agriculture, aquaculture, horticulture and forestry; Weed killing; Physical therapy; Gardening; Hair implantation; Lawn care; Massage; Medical equipment rental; Rental of sanitary installations; Farming equipment rental; Horticulture; Hospices; Tree planting for carbon offsetting purposes; Animal grooming; Beauty salons; Hair salon services; Sanatoriums; Plant nurseries; Opticians' services; Aquaculture services; Aromatherapy services; Health spa services; Blood bank services; Medical clinic services; Preparation of prescriptions by pharmacists; In vitro fertilization services; Landscape gardening; Medical nursing; Artificial insemination services; Speech therapy; Manicuring; Alternative medicine services; Orthodontic services; Midwife services; Psychologist (Services of a -); Sauna services; Solarium services; Telemedicine services; Visagists' services; Medical assistance; Hospitals; Medical services; Therapy services; Aerial and surface spreading of fertilizers and other agricultural chemicals; Animal grooming; Tattooing.
82.
Notch inhibitors for use in the treatment of t-cell acute lymphoblastic leukemia
C07D 309/32 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
C07D 309/12 - Atomes d'oxygène uniquement des atomes d'hydrogène et un atome d'oxygène liés directement aux atomes de carbone du cycle, p.ex. éthers du tétrahydropyranne
A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
C07C 49/248 - Composés non saturés comportant des groupes cétone liés à des atomes de carbone acycliques contenant des groupes hydroxyle contenant des cycles aromatiques à six chaînons avec insaturation autre que celle des cycles aromatiques
C07C 49/835 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons contenant des groupes hydroxyle avec insaturation autre que celle d'un cycle aromatique
C07C 49/84 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons contenant des groupes éther, des groupes , des groupes ou des groupes
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Santanelli Di Pompeo, Fabio
Longo, Benedetto
Abrégé
A system for monitoring a flow of an organ and of the body fluid of a patient by Doppler echography, comprising a portable Doppler probe (10) configured to be applied to the body of the patient, wherein the probe comprises a matrix of transducers (11), each transducer being configured to emit in use a respective output ultrasound signal directed towards the body of the patient, receive a respective input ultrasound signal reflected by the body of the patient, and convert the input ultrasound signal into a reading signal, and a main detection unit (20) configured to wirelessly communicate with the portable probe (10), and construct an image of a reflecting biological surface according to the features of the reflected ultrasound waves, identify a body fluid in motion and calculate the speed and direction thereof based on the reading signals provided by the array of transducers (11).
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
Tiziano, Francesco Danilo
Infante, Paola
Di Marcotullio, Lucia
Abiusi, Emanuela
Abrégé
The present invention relates to specific inhibitors for human microRNAs, for use in the treatment of spinal muscular atrophy (SMA) and pharmaceutical compositions including them. The present invention further relates to the identification of markers with high sensitivity and specificity for the prognosis of a spinal muscular atrophy (SMA), prognostic methods comprising the use of such markers and prognostic kits for detecting such markers.
ISTITUTO NAZIONALE TUMORI I.R.C.C.S. "FONDAZIONE G. PASCALE" (Italie)
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Ciliberto, Gennaro
Ascierto, Paolo Antonio
Fattore, Luigi
Botti, Gerardo
Mancini, Rita
Abrégé
The present invention concerns miRNAs for in vitro diagnosis of resistance of tumors to BRAF/MEK pathway (also named as MAPK 5 pathway) inhibiting drugs and for treatment of tumors which are treated with said drugs, such as melanoma, by stimulating or inhibiting the expression of down-regulated or up-regulated miRNAs, respectively.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
86.
MIRNAS FOR TREATMENT AND IN VITRO DIAGNOSIS OF DRUG RESISTANT TUMORS
ISTITUTO NAZIONALE TUMORI I.R.C.C.S. "FONDAZIONE G. PASCALE" (Italie)
UNIVERSITA' DEGLI SUTDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Ciliberto, Gennaro
Ascierto, Paolo Antonio
Fattore, Luigi
Botti, Gerardo
Mancini, Rita
Abrégé
The present invention concerns miRNAs for in vitro diagnosis of resistance of tumors to BRAF/MEK pathway (also named as MAPK 5 pathway) inhibiting drugs and for treatment of tumors which are treated with said drugs, such as melanoma, by stimulating or inhibiting the expression of down-regulated or up-regulated miRNAs, respectively.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
87.
PROCESS FOR THE PRODUCTION OF PROTECTED OXIDIZABLE METAL PARTICLES AND CORRELATED PRODUCTS
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Stoller, Marco
Vilardi, Giorgio
Di Palma, Luca
Verdone, Nicola
Abrégé
The invention refers to a process for the production of oxidizable submicronic particles (nanoparticles) comprising one or more zero-valent metals and incorporated inside a crystallized solid matrix. In particular, the invention refers to a two-step process: (1) synthesis of the metal particles in a solution; (2) crystallization by heterogeneous nucleation of the solute onto the produced particles. The invention also relates to oxidizable metal particles in a crystallized solid matrix, obtained by the process of present invention, and to the uses of these metal particles in the industrial and environmental field.
B22F 1/00 - Poudres métalliques; Traitement des poudres métalliques, p.ex. en vue de faciliter leur mise en œuvre ou d'améliorer leurs propriétés
B22F 9/24 - Fabrication des poudres métalliques ou de leurs suspensions; Appareils ou dispositifs spécialement adaptés à cet effet par un procédé chimique avec réduction de mélanges métalliques à partir de mélanges métalliques liquides, p.ex. de solutions
C02F 1/70 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par réduction
88.
COOLING AND ENERGY RECOVERY SYSTEM FOR DEVICES PRODUCING EXCESS HEAT, AND RELATED COOLING METHOD
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Sciubba, Enrico
Abrégé
A cooling system (1), and a related method, for devices which produce excess heat, allows an extraction of residual heat from the circulating fluids more effectively with respect to the conventional systems, so that the residual heat could be recovered and exploited, in case even to increase the overall effectiveness of the cooling system, and it comprises: a heat exchanger (2) with two cooling circuits (4, 5) and respective coolants with a negative enthalpy of mixing, means for circulating the refrigerant fluids; means (20) for mixing the coolants for the enthalpy exothermic release in the obtained mixture; and means (23) for extracting heat from said mixture, wherein the outlet temperatures (T2) from the exchanger (2) of the two coolants have a temperature difference lower than 5°C.
F01K 9/00 - Ensembles fonctionnels de machines à vapeur caractérisés par des condenseurs disposés ou modifiés de façon à s'adapter aux machines motrices
F01K 25/08 - Ensembles fonctionnels ou machines motrices caractérisés par l'emploi de fluides énergétiques particuliers non prévus ailleurs; Ensembles fonctionnant selon un cycle fermé, non prévus ailleurs utilisant des vapeurs particulières
F25B 15/00 - Machines, installations ou systèmes à sorption, à marche continue, p.ex. à absorption
89.
METHOD FOR THE PRODUCTION OF POLYHYDROXYALKANOATES (PHAS) FROM HIGH SOLID CONTENT ORGANIC WASTE
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
UNIVERSITA' CA' FOSCARI (Italie)
UNIVERSITA' DEGLI STUDI DI VERONA (Italie)
Inventeur(s)
Majone, Mauro
Valentino, Francesco
Pavan, Paolo
Bolzonella, David
Micolucci, Federico
Gottardo, Marco
Abrégé
A process for the biosynthesis of PHAs from the organic fraction of metropolitan solid waste. The process uses a mixed microbial consortium (MMC) and combines three stages in sequence (Stage I: anaerobic fermentation, Stage II: sequential aerobic fermentation, Stage III: batch aerobic fermentation). The material leaving the fermentation Stage I reactor is initially conveyed through a filter which reduces its content of suspended solids without significantly interfering with the concentration of VFAs and nutrients, such as phosphorus (P) and nitrogen (N), elements that in Stage II, favour the production of the MMC biomass specialized in the synthesis of PHAs, used in the subsequent Stage III. The flow is then divided between the Stage II reactor and a second filter with membrane that eliminates its suspended solid particulate matter and reduces the concentration of P and N, thus favouring the synthesis of PHAs by the microorganisms during Phase III.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Al Mansour, Monir
Abrégé
Circumcision device, including a support (10), a rest part (20) comprising a stem (21) and a shearing template (23) arranged fastened on a distal end of the stem (21), which has a concave distal surface (23a) and a side surface (23b) tapered in the proximal direction, and a pair of arms (30, 30') each having a distal end provided with a semi-circular blade (32, 32'). Each arm is rotatable around an axis perpendicular (y, y') to the extension direction of the stem (21), between an open position and a shearing position wherein the semi- circular blades (32, 32') are closed to form a ring perpendicular to the extension axis of the stem (21) and have a cutting edge (33, 33') that engages the side surface (23b) of the shearing template (23). The rest part (20) is removably fastened to the support (10) and the semi-circular blades (32, 32') are removably fastened to their respective levers (30, 30'). Each lever (30, 30') is provided with a guide (31a, 31a') to determine the orientation of the respective semi-circular blade (32, 32').
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Sterpetti, Antonio Vittorio
Abrégé
Method and relative system for the measurement of haemodynamic indices, said method comprising: acquiring an ultrasound image of at least one segment of an arterial vessel; identifying in said image at least one sample volume; obtaining a time series indicating the blood velocity, or velocity signal (9), in said sample volume and in at least one cardiac cycle; calculating, by means of a processor, a first area (4) equal to the area subtended by the velocity signal (9) between the sample (6) relating to the instant of systole start of said at least one cardiac cycle and the sample (7) of systolic peak; calculating, by means of a processor, a second area (5) subtended by the velocity signal (9) between the sample (7) of systolic peak and the sample (8) relating to the instant of end diastole of said at least one cardiac cycle; calculating the relationship between the second area (5) and the first area (4); selecting a time instant of interest in said at least one cardiac cycle; obtaining the spatial distribution of the velocity in said time instant of interest, or instantaneous distribution of the velocity; identifying the maximum value and the minimum value of the instantaneous distribution of the velocity; and calculating the relationship between the maximum value and the minimum value.
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
Inventeur(s)
Limatola, Cristina
D'Alessandro, Giuseppina
Di Marcotullio, Lucia
Infante, Paola
Botta, Bruno
Mori, Mattia
Ghirga, Francesca
Ingallina, Cinzia
Berardozzi, Simone
Abrégé
The present invention relates to a compound of formula (1): (1) or an analogue thereof or a pharmaceutically acceptable salt thereof, for use in the treatment of a brain tumor, wherein said compound is administered intranasally and relative pharmaceutical compositions.
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p.ex. PEG, PPG, PEO ou polyglycérol
93.
USE OF A PEPTIDE DERIVED FROM THE HUMAN PROTEIN NTIMP3 IN THE TREATMENT OF DIABETIC NEPHROPATHY
UNIVERSITA' DEGLI STUDI DI ROMA "TOR VERGATA" (Italie)
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Federici, Massimo
Menghini, Rossella
Casagrande, Viviana
Menini, Stefano
Abrégé
The present invention relates to fusion peptides consisting of the peptide fragment corresponding to the N-terminal domain derived from the human TIMP3 protein, both in native and mutated form, bound by the N-terminal end to a highly selective and efficient carrier peptide for transport in renal proximal tubule cells, the medical use thereof, in particular the use thereof in the treatment of diabetic nephropathy, and the compositions comprising them.
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
94.
METHOD AIMED AT PATIENTS WITH MOTOR DISABILITIES FOR SELECTING A COMMAND BY MEANS OF A GRAPHIC INTERFACE, AND CORRESPONDING SYSTEM AND COMPUTER PROGRAM PRODUCT
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
ISTITUTO SUPERIORE DI SANITA' (Italie)
Inventeur(s)
Cincotti, Febo
Ferriero, Dario Giuseppe
Giuseppi, Alessandro
Pietrabissa, Antonio
Ricciardi Celsi, Lorenzo
Poli, Cecilia
Abrégé
v, ωv, ω) of the movement of the cursor. In particular, the estimation procedure (1020) comprises optimisation, for example by means of MPC (Model Predictive Control), of a cost function determined as a function o the estimated target function.
G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
G06F 3/0481 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] fondées sur des propriétés spécifiques de l’objet d’interaction affiché ou sur un environnement basé sur les métaphores, p.ex. interaction avec des éléments du bureau telles les fenêtres ou les icônes, ou avec l’aide d’un curseur changeant de comport
G06F 3/0484 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] pour la commande de fonctions ou d’opérations spécifiques, p.ex. sélection ou transformation d’un objet, d’une image ou d’un élément de texte affiché, détermination d’une valeur de paramètre ou sélection d’une plage de valeurs
95.
OLEUROPEIN FOR USE IN REDUCING POST-PRANDIAL GLYCAEMIA
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p.ex. leucoglucosane, hespéridine, érythromycine, nystatine
A61K 36/63 - Oleaceae (famille de l'olive), p.ex. jasmin, lilas ou frêne
A61P 3/08 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p.ex. antidiabétiques
96.
COMPOSITION FOR USE IN THE FINISHING, PRESERVATION, RESTORATION OF MANUFACTURES
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
UNIVERSITA' DEGLI STUDI DI PALERMO (Italie)
Inventeur(s)
Bianco, Armandodoriano
Serafini, Ilaria
Cavallaro, Giuseppe
Lazzara, Giuseppe
Abrégé
An aqueous composition comprising chitosan and fibroin nanoparticles, with a diameter equal or lower than 140 nm, and an acid agent, with pH equal or lower than 6, and viscosity equal or lower than 3.5 kg × m−1× s−1 measured at 25.0±0.1 °C, kit and method for finishing and/or preservation and/or restoration and/or renovation and/or repairing and/or consolidation of manufactures, in particular ancient manufactures are disclosed.
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Italie)
Inventeur(s)
Palma, Fabrizio
Abrégé
An assembly (1) for the deposition of silicon nanostructures comprising a deposition chamber (2), which is defined by a side wall (3) and by two end walls (4); a microwave generator (5), which is adapted to generate microwaves inside the deposition chamber (2); an electromagnetic termination wall (8), made of a conductor material and reflecting the microwave radiation, which is such as to create a termination for a TE-mode waveguide and is housed inside the deposition chamber (2); and a substrate-carrier support (9), which is made of a dielectric material and on which the substrate is housed on which to perform the growth of silicon nanostructures. The substrate-carrier support (9) is arranged inside the deposition chamber (2) above the termination wall (8).
H01L 21/67 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitement; Appareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants
98.
Process for the production of antimicrobial dental adhesives including graphene and relative product thereof
UNIVERSITA' DEGLI STUDI DI ROMA “LA SAPIENZA” (Italie)
Inventeur(s)
Sarto, Maria Sabrina
Polimeni, Antonella
Uccelletti, Daniela
Bossu′, Maurizio
Bregnocchi, Agnese
Chandraiahgari, Chandrakanth Reddy
Zanni, Elena
De Angelis, Francesca
Abrégé
Disclosed is a dental adhesive including a polymeric adhesive and a nanofiller dispersed in the polymeric adhesive, the nanofiller being constituted by graphene nanostructures which are properly dispersed inside the polymer adhesive and over the surface of the adhesive layer without formation of agglomerates, so that the dental adhesive exhibits significant antimicrobial and antibiofilm properties against pathogens of the oral cavity.
A61K 6/30 - Compositions pour fixer temporairement ou de façon permanente les dents ou les palais, p.ex. apprêts pour adhésifs dentaires
A61K 6/884 - Préparations pour la fabrication de dents artificielles, l’obturation ou le recouvrage des dents comprenant des résines naturelles ou synthétiques
A61K 6/76 - Charges comprenant des composés contenant du silicium
A61K 6/831 - Emploi d'éléments non métalliques ou de leurs composés, p.ex. de carbone
UNIVERSITA' DEGLI STUDI DI ROMA LA SAPIENZA (Italie)
Inventeur(s)
Mcdermott, Alison
Mangoni, Maria Luisa
Abrégé
Provided herein are synthetic antibacterial peptides that have a sequence at least 80% identical to a sequence shown in SEQ ID NO: 2 or the diastereomer thereof with a sequence shown in SEQ ID NO: 3 or pharmaceutical compositions thereof. Also provided are methods for stimulating wound healing via the synthetic antibacterial peptides and for forming an antimicrobial coating on contact lenses. In addition a device is provided that has a surface with a coating of the synthetic antibacterial peptides.
A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
C07K 14/46 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés
A61L 12/14 - Procédés ou appareils pour la désinfection ou la stérilisation des lentilles de contact; Accessoires à cet effet utilisant des substances chimiques des composés organiques non couverts par les groupes ou
A61K 38/04 - Peptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminée; Leurs dérivés
B29D 11/00 - Fabrication d'éléments optiques, p.ex. lentilles ou prismes
G02B 1/04 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES Éléments optiques caractérisés par la substance dont ils sont faits; Revêtements optiques pour éléments optiques faits de substances organiques, p.ex. plastiques
100.
Mechanical gun-type circumcision device with glans protection system for safe cutting and cauterization of the foreskin
UNIVERSITA' DEGLI STUDI DI ROMA ‘LA SAPIENZA’ (Italie)
Inventeur(s)
Al Mansour, Monir
Abrégé
b) of the shearing template (23), and an actuating mechanism (40) for controlling rotation of the arms (30, 30′) in response to an actuation of the control member (15).
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets