C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
C12N 13/00 - Traitement de micro-organismes ou d'enzymes par énergie électrique ou ondulatoire, p. ex. par magnétisme, par des ondes sonores
G01N 15/1404 - Manipulation du flux, p. ex. focalisation hydrodynamique
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
2.
LIGAND-SUPPORTED PEROVSKITE LUMINESCENT CRYSTAL COMPOSITION AND METHOD FOR PRODUCING THE SAME
A perovskite luminescent crystal composition including perovskite luminescent crystals bearing a polymeric surface ligand having a molecular weight of at least 700 g/mol, wherein the polymeric surface ligand is a polymer including a backbone and side chains, wherein at least one side chain includes at least one functional group selected from amines, carboxylates, phosphates, thiols or combinations thereof, wherein the binding of the perovskite luminescent crystals to the surface ligand occurs through the surface ligand's functional groups, thereby forming a perovskite luminescent crystal-ligand complex, and wherein the perovskite luminescent crystal-ligand complex is embedded in a polymer.
C09K 11/08 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes
C09K 11/02 - Emploi de substances particulières comme liants, revêtements de particules ou milieux de suspension
H01L 33/50 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les éléments du boîtier des corps semi-conducteurs Éléments de conversion de la longueur d'onde
A ligand regulated protein-protein interaction system based on a lipocalin-fold molecule including: (a) a lipocalin-fold molecule; (b) a lipocalin-fold ligand with a low molecular weight of 1500 Da or below; and (c) a lipocalin-fold binding interaction partner, wherein the lipocalin-fold molecule can bind to the lipocalin-fold ligand; and wherein the lipocalin-fold molecule bound to the lipocalin-fold ligand binds to the lipocalin-fold binding interaction partner with an affinity which is at least 10-fold higher than the affinity of the lipocalin-fold molecule not bound to the lipocalin-fold ligand; and wherein the lipocalin-fold binding interaction partner is not a naturally occurring protein which has an affinity of <10 μM to any naturally occurring lipocalin-fold molecule in the presence of any lipocalin-fold ligand.
The invention refers to a mechanical and universally effective insect barrier, which is a composition, comprising microparticles having an outer shell, comprising shellac or a tree resin, and an inner matrix, comprising beeswax and at least one insect and/or arachnid repellent; and an adhesion promoting agent, its use for protecting plants or subjects against insects and arachnids and a method for producing the microparticles.
A01N 65/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux contenant du matériel provenant d'algues, de lichens, de bryophytes, de champignons multicellulaires ou de plantes, ou leurs extraits
A01N 65/10 - Apiaceae ou Umbelliferae [famille de la carotte], p. ex. persil, carvi, aneth, livèche, fenouil ou "snakebed" [Cnidium monnieri]
A01N 65/22 - Lamiaceae ou Labiatae [famille de la menthe], p. ex. thym, romarin, scutellaire, brunelle, lavande, perilla, menthe pouliot, menthe poivrée ou menthe verte
A01N 65/26 - Meliaceae [famille du margousier ou de l'acajou], p. ex. acajou, langsat ou Azadirachta
A01N 65/28 - Myrtaceae [famille du myrte], p. ex. cajeputier ou clou de girofle
The present invention relates in general to the use of a kit or composition comprising at least one yeast and at least one bacterium, selected from the group consisting of lactobacillales, rhizobiales and bifidobacteriales, and/or comprising calcium for improving plant health, for improving plant resistance to plant pathogens, for preventing or reducing mycotoxin contamination of plant material, for improving plant resistance to a plant disease, for preventing perithecia formation of a plant pathogen on plant debris, for plant protection and/or as plant stimulant. The present invention also relates to corresponding compositions and kits and a method of applying such composition or kit to a living plant or plant debris.
The present invention refers to a temperature resistant dental implant container with dental implant comprising a polygonal or cylindrical, optically transparent container with a conically tapered interior for receiving a dental implant, a needle-pierceable, flexible, and liquid-tight septum, a lid which is separably connected to the container, wherein the interior of the container is configured to fix the position of the dental implant between the bottom of the septum and the bottom of the interior, and a dental implant comprising a conditioned surface. Further its use for transport and storage, and a method for in vitro cellular coating a dental implant are described.
A61C 8/02 - Moyens pour la transfixation des dents naturelles
A61C 8/00 - Moyens destinés à être fixés à l'os de la mâchoire pour consolider les dents naturelles ou pour y assujettir des prothèses dentairesImplants dentairesOutils pour l'implantation
8.
Method for determining a focal length of a particle in a medium
A method for determining a focal length of a particle in a medium, wherein the method comprises: providing a sample; emitting a coherent light beam to irradiate the sample, wherein a first part of the light beam is scattered by the particle; recording an interference image; computing for a set of positions an electric field from the interference image; generating a representation comprising, for each of said positions, an intensity value of the coherent light beam calculated from the computed electric field; finding two positions, a first of which lies in the sample, a second of which lies in the beam direction behind or in front of said first position; and determining the focal length from the two found positions.
The present device (10) for charging concrete (25) in tremie pipe (23) comprises a shank (1), ribs (2) hingedly connected to the shank (1), the ribs (2) extending radially from the shank (1). A canopy (6) is attached to the ribs (2). The angular range of motion (P) of the ribs (2) about their connection to the shank (1) in respect of the longitudinal extension of the shank (1) is greater than 120°, preferably greater than 150°. The device (10) is designed for the first charging of tremie pipe (23) with concrete. The device (10) is robust to survive the harsh site conditions and is flexible to be adapted to different tremie pipe diameter and pile length. The device enables controlled descending of concrete to initiate pouring. By controlled descending speed of concrete the mixing of concrete with supporting fluid and the segregation of concrete are avoided.
The present invention relates to a method for producing a composite material, wherein the composite material is an agglomerate which comprises chips of lignocellulosic biomass, in particular wood, the chips being connected to a water-weakenable, reversibly bindable binder, and the method comprising the following steps: (a) providing loose chip material, comprising or consisting of chips that are wetted at their surface at least partially, preferably fully, with the binder, (b) optionally adjusting the water content of the chip material, and (c) pressing the chip material to obtain the composite material, the chip material having a water content prior to the pressing of between 5 wt.% and 40 wt.% in relation to its total weight, the temperature of the pressed chip material in a first pressing phase being at least 100°C. The invention further relates to a composite material.
A method for determining a property of at least one particle (P) in a medium (M), comprising: emitting a coherent light beam (6) to irradiate a sample (5) of the medium (M); recording an interference image (10) of a first part of the light beam (6) scattered by the at least one particle (P) and a second part of the light beam (6) not scattered by particles (P); computing (S1), for positions (13) within the sample (5), an electric field (E1) of the first part from the interference image (10); generating (S2) a representation (16) comprising for each position (13), a phase value (ξ), determined from the computed electric field (E1) and from an estimated electric field (E2) of the second part, and an intensity value (I), determined from the intensity (I1) of the first part and from the phase value (ξ); and determining (S3), therefrom, said property.
The present invention refers to a recombinant anti-SARS CoV-2 antibody with enhanced viral neutralization potency comprising an lgG3 constant and hinge region with one or more engineered glycans. The invention refers also to a nucleic acid encoding the anti-SARS CoV-2 antibody, plant cells expressing the anti-SARS CoV-2 antibodies, a method for production of anti-SARS CoV-2 antibody, and a pharmaceutical composition comprising anti-SARS CoV-2 antibody. The invention also refers to the use of an anti-SARS CoV-2 antibody for detecting SARS CoV-2 in a sample, the use for the manufacture of a medicament, and the use for treating or preventing diseases associated with coronavirus infections.
C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61P 31/14 - Antiviraux pour le traitement des virus ARN
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G01N 33/577 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet faisant intervenir des anticorps monoclonaux
13.
CONTINUOUS RECONSTITUTION OF PROCESS MATERIALS FROM SOLIDS
A system and a method for on-demand reconstituting solid process material is disclosed. The system comprises a feeding device for continuously feeding said solid process material, a mixing vessel, optionally a hold tank, optionally one or more mixing reactors, and optionally a sterile filter unit, wherein the system is configured to operate continuously.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
15.
LIGAND-SUPPORTED PEROVSKITE LUMINESCENT CRYSTAL COMPOSITION AND METHOD FOR PRODUCING THE SAME
Perovskite luminescent crystal composition comprising perovskite luminescent crystals bearing a polymeric surface ligand having a molecular weight of at least 700 g/mol, wherein the polymeric surface ligand is a polymer comprising a backbone and side chains, wherein at least one side chain comprises at least one functional group selected from amines, carboxylates, phosphates, thiols or combinations thereof, wherein the binding of the perovskite luminescent crystals to the surface ligand occurs through the surface ligand's functional groups, thereby forming a perovskite luminescent crystal-ligand complex, and wherein the perovskite luminescent crystal-ligand complex is embedded in a polymer.
C09K 11/02 - Emploi de substances particulières comme liants, revêtements de particules ou milieux de suspension
C09K 11/66 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du germanium, de l'étain ou du plomb
The present invention relates to a genetically modified plant or plant cell derived from a wild-type plant or plant cell, said wild-type plant or plant cell producing at least one serine protease comprising the motif SSRGPX1LKPDX2X3APGX4SGTSMSCPHX5PX6WSPX7AX8X9SAX10MTT (SEQ ID No. 1), wherein
The present invention relates to a genetically modified plant or plant cell derived from a wild-type plant or plant cell, said wild-type plant or plant cell producing at least one serine protease comprising the motif SSRGPX1LKPDX2X3APGX4SGTSMSCPHX5PX6WSPX7AX8X9SAX10MTT (SEQ ID No. 1), wherein
X1 is a peptide consisting of 7 amino acid residues, X2 is I or L, X3 is T or M, X4 is a peptide consisting of 27 or 28 amino acid residues, X5 is a peptide consisting of 12 amino acid residues, X6 is T or E, X7 is S or A, X8 is V or I, X9 is K or R and X10 is I or M, wherein the proteolytic activity of the at least one serine protease in the genetically modified plant or plant cell is reduced compared to its activity in the wild-type plant or plant cell, wherein the genetically modified plant or plant cell comprises at least one exogenous nucleic acid molecule encoding for at least one protein or polypeptide of interest.
A method is provided for preparing a water-insoluble lignosulfonate polymer from a first solution containing lignosulfonate precursors, which involves
a) separating the lignosulfonate precursors from the first solution and providing a second solution with at least 5 wt % of lignosulfonate precursors obtained from the first solution, wherein the separating comprises filtering out components with a predefined particle diameter and separating low-molecular weight components including salts and low-molecular organic compounds,
b) adding a radical-forming enzyme and gas to the second solution, wherein the gas comprises oxygen, and
c) polymerizing the lignosulfonate precursors of the resultant solution of b).
A method is provided for preparing a water-insoluble lignosulfonate polymer from a first solution containing lignosulfonate precursors, which involves
a) separating the lignosulfonate precursors from the first solution and providing a second solution with at least 5 wt % of lignosulfonate precursors obtained from the first solution, wherein the separating comprises filtering out components with a predefined particle diameter and separating low-molecular weight components including salts and low-molecular organic compounds,
b) adding a radical-forming enzyme and gas to the second solution, wherein the gas comprises oxygen, and
c) polymerizing the lignosulfonate precursors of the resultant solution of b).
Other related aspects are described and claimed.
C08H 8/00 - Composés macromoléculaires dérivés de matériaux lignocellulosiques
C12P 11/00 - Préparation de composés organiques contenant du soufre
C08J 9/12 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par un agent de gonflage introduit au préalable par un agent physique de gonflage
A01G 24/35 - Substrats de cultureMilieux de cultureAppareils ou méthodes à cet effet basés sur ou contenant des composés organiques synthétiques contenant des polymères absorbant l’eau
A recombinant methanol utilization pathway deficient methylotrophic yeast (Mut-) host cell which is engineered: a) by one or more genetic modifications to reduce expression of a first and a second endogenous gene compared to the host cell prior to said one or more genetic modifications, wherein i. the first endogenous gene encodes alcohol oxidase 1 (AOX1) comprising the amino acid sequence identified as SEQ ID NO:1 or a homologue thereof, and ii. the second endogenous gene encodes alcohol oxidase 2 (AOX2) comprising the amino acid sequence identified as SEQ ID NO:3 or a homologue thereof, and b) by one or more genetic modifications to increase expression of an alcohol dehydrogenase (ADH2) gene compared to the host cell prior to said one or more genetic modifications, wherein the ADH2 gene encodes an alcohol dehydrogenase (ADH2).
C12N 15/81 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour champignons pour levures
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
The preset invention relates to a chromatographic system comprising a porous bed with uniform structure throughout the entire chromatographic bed to the sidewall and use thereof.
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 20/285 - Absorbants ou adsorbants poreux à base de polymères
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
The invention refers to a recombinant human diamine oxidase (DAO) with decreased glycosaminoglycan binding affinity, wherein said DAO comprises at least one amino acid modification in the glycosaminoglycan (GAG) binding domain. The present invention also refers to the use of the DAO in the treatment of a condition associated with excess histamine, specifically in the treatment of chronic allergic diseases, more specifically in the treatment of anaphylaxis, anaphylactic shock, chronic urticaria, acute urticaria, asthma, hay fever, allergic rhinitis, allergic conjunctivitis, histamine intoxication, headache, atopic dermatitis inflammatory diseases, mastocytosis, mast cell activation syndrome (MCAS), pre-eclampsia, hyperemesis gravidarum, pre-term labor, peptic ulcers, acid reflux, pruritus, and sepsis.
An extracellular domain of CD19 (CD19-ECD) which comprises at least 90% sequence identity to SEQ ID NO:1, a first core region at positions 2-98 of SEQ ID NO:1, a second core region at positions 167-258 of SEQ ID NO:1, a third core region at positions 99-166 of SEQ ID NO:1, and at least one stabilizing point mutation at an amino acid position within said first and/or second and/or third core regions, wherein the CD19-ECD has an increased thermal stability compared to CD19-ECD which consists of an amino acid sequence identified as SEQ ID NO:1.
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
22.
USE OF MICROORGANISMS AND CALCIUM FOR IMPROVED PLANT HEALTH AND/OR RESILIENCE AGAINST PLANT PATHOGENS
The present invention relates in general to the use of a kit or composition comprising at least one yeast and at least one bacterium, selected from the group consisting of lactobacillales, rhizobiales and bifidobacteriales, and/or comprising calcium for improving plant health, for improving plant resistance to plant pathogens, for preventing or reducing mycotoxin contamination of plant material, for improving plant resistance to a plant disease, for preventing perithecia formation of a plant pathogen on plant debris, for plant protection and/or as plant stimulant. The present invention also relates to corresponding compositions and kits and a method of applying such composition or kit to a living plant or plant debris.
Disclosed is a group of chimeric antigen receptors (CARs) having two, three or four CAR molecules,
wherein each member of the group of CARs is different in its amino acid sequence from one another, and
wherein each of the CAR molecules of the group include at least a transmembrane domain and an ectodomain, wherein the ectodomain has one or two antigen binding moieties and/or one or two binding sites to which other polypeptides each including at least an antigen binding moiety are able to bind;
wherein the ectodomain of each CAR molecule of the group in its prevalent conformation is free of cysteine amino acid moieties which are able to form intermolecular disulphide bonds with other CAR molecules of the group, respectively, and
wherein each CAR molecule of the group includes at least one heterodimerization domain.
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
C07K 14/71 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des facteurs de croissanceRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des régulateurs de croissance
C07K 16/32 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des produits de traduction des oncogènes
C07K 14/715 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des cytokinesRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des lymphokinesRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des interférons
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
24.
DUAL VECTOR SYSTEM FOR IMPROVED PRODUCTION OF PROTEINS IN ANIMAL CELLS
The present invention refers to a dual vector system for production of one or more recombinant proteins in cells of insect origin comprising a first viral vector comprising a T7 promoter operably linked to a targeting sequence comprising a non-coding sequence and which expression can suppress one or more proteins essential for virus production, followed by a T7 termination sequence, and a second viral vector comprising a promoter operably linked to a T7 RNA polymerase encoding sequence, and at least one gene sequence located on the first and/or second vector encoding one or more recombinant proteins of interest. The invention further refers to recombinant insect cells comprising the dual vector system and methods for producing recombinant proteins using said dual vector CA system.
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
C12N 11/16 - Enzymes ou cellules microbiennes immobilisées sur ou dans une cellule biologique
C07K 14/395 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de champignons provenant de levures provenant de Saccharomyces
A group of chimeric antigen receptors (CARs) having two, three or four CAR molecules,
wherein the members of the group of CARs can be different in their amino acid sequences, and
wherein each of the CAR molecules of the group includes at least a transmembrane domain and an ectodomain comprising either an antigen binding moiety or a binding site to which another polypeptide is able to bind, wherein the polypeptide comprises an antigen binding moiety;
wherein each CAR molecule of the group includes at least one dimerization domain, wherein this dimerization of a pair of dimerization domains is either induced by a regulating molecule and optionally reduced by another regulating molecule, or occurs in the absence of a regulating molecule and is reduced by a regulating molecule, and
wherein the antigen binding moieties of the CAR molecules of the group specific for one target antigen.
The invention relates to a composition comprising one or more inhibitors capable of inhibiting at least two of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and lipoxygenase or a composition comprising one or more inhibitors capable of inhibiting an enzyme with arachidonate-Co A ligase activity, specifically long-chain-fatty-acid-Co A ligase (ACSL) 1, ACSL3, ACSL4, ACSL5, ACSL6, SLC27A2 or ACSBG2, or a combination thereof for use in selectively eliminating senescent cells. The invention further relates to an in vitro method of identifying senescent cells in a subject and to a method of identifying candidate compounds for the selective elimination of senescent cells.
A61K 31/661 - Acides du phosphore ou leurs esters n'ayant pas de liaison P-C, p. ex. fosfosal, dichlorvos, malathion
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
30.
Method for determining a three-dimensional particle distribution in a medium
The disclosed subject matter relates to a method for determining a three-dimensional particle distribution in a medium, comprising: emitting a coherent light beam to irradiate the sample; recording an interference image of the scattered light beam and a second part of the light beam that has not been scattered; computing, from the interference image, for each one of a plurality of virtual planes lying within the sample, a reconstructed image of the sample, generating for each reconstructed image, a presence image, wherein a value is assigned to each pixel of the presence images if the corresponding pixel of the reconstructed image has an intensity value exceeding a threshold value and if the corresponding pixel of the reconstructed image has a phase value with a predetermined sign.
A system and a method for on-demand reconstituting solid process material is disclosed. The system comprises a feeding device for continuously feeding said solid process material, a mixing vessel, optionally a hold tank, optionally one or more mixing reactors, and optionally a sterile filter unit, wherein the system is configured to operate continuously.
A method for producing a fermentation product in a cell culture, comprising: a. determining optimized process parameters for culturing a high producer cell line to produce said fermentation product, wherein the determining step of a. is made upon cell culture employing a multiplexed microfluidic perfusion cell culture device in perfusion mode, and wherein the high producer cell line is optionally selected from a repertoire of cell lines capable of producing said fermentation product; and b. culturing said high producer cell line by an industrial scale method under the selected process parameters to produce said fermentation product.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
The present invention refers to a method for the selection of target-specific proteases using bacterial cells comprising at least one circularly permuted bacterial enzyme essential for growth of said cells under selection conditions, comprising at its N- or C-terminus one or more foreign amino acids inactivating its enzymatic activity and a protease recognition site for target-specific proteolytic cleavage, wherein upon target- specific proteolytic cleavage and removal of the foreign amino acids its enzymatic activity is restored, wherein said cells do not comprise said bacterial enzyme in enzymatically active form, introducing at least one protease into the host cells, maintaining said host cells under conditions to allow target-specific cleavage of the circularly permuted bacterial enzyme by the protease, selecting host cells capable of growing under selection conditions, and isolating the target-specific protease from said host cells. The present invention also refers to circular permuted bacterial enzymes and bacterial host cells, specifically for use in the selection method.
The present invention relates to a novel method for detoxification of trichothecene contaminated material. More specifically, the present invention pertains to a method for biotransformation of a trichothecene by contacting material contaminated with trichothecenes with an exogenous non-animal glutathione-S-transferase (GST) having substrate specificity for the epoxide ring of the trichothecene. The invention further relates to recombinant GSTs and transgenic plants and animals expressing said GSTs.
C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
A23L 5/20 - Élimination de constituants indésirables, p. ex. désodorisation ou détoxication
A23K 10/14 - Prétraitement de produits alimentaires avec des enzymes
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
A23K 10/30 - Produits alimentaires pour animaux à base de matières d’origine végétale, p. ex. de racines, de graines ou de foinProduits alimentaires pour animaux à base de matières d’origine fongique, p. ex. de champignons
35.
Ligand regulated protein-protein interaction system
and wherein the lipocalin-fold binding interaction partner is not a naturally occurring protein which has an affinity of <10 μM to any naturally occurring lipocalin-fold molecule in the presence of any lipocalin-fold ligand.
The present invention relates to an ultrathin membrane having a thickness of less than about 100 nm and exhibiting different textured surfaces, wherein one side to the membrane exhibits an uneven textured surface when compared to the other side of the membrane.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
C08J 9/26 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par élimination d'une phase solide d'un objet ou d'une composition macromoléculaire, p. ex. par lessivage
An extracellular domain of CD19 (CD19-ECD) which comprises at least 90% sequence identity to SEQ ID NO:1, a first core region at positions 2-98 of SEQ ID NO:1, a second core region at positions 167-258 of SEQ ID NO:1, a third core region at positions 99-166 of SEQ ID NO:1, and at least one stabilizing point mutation at an amino acid position within said first and/or second and/or third core regions, wherein the CD19-ECD has an increased thermal stability compared to CD19-ECD which consists of an amino acid sequence identified as SEQ ID NO:1.
The invention refers to a recombinant human diamine oxidase (DAO) with decreased glycosaminoglycan binding affinity, wherein said DAO comprises at least one amino acid modification in the glycosaminoglycan (GAG) binding domain. The present invention also refers to the use of the DAO in the treatment of a condition associated with excess histamine, specifically in the treatment of chronic allergic diseases, more specifically in the treatment of anaphylaxis, anaphylactic shock, chronic urticaria, acute urticaria, asthma, hay fever, allergic rhinitis, allergic conjunctivitis, histamine intoxication, headache, atopic dermatitis inflammatory diseases, mastocytosis, mast cell activation syndrome (MCAS), pre-eclampsia, hyperemesis gravidarum, pre-term labor, peptic ulcers, acid reflux, pruritus, and sepsis.
The invention relates to a method for producing a water-insoluble lignosulfonate polymer from a solution containing a lignosulfonate precursor, in particular from raw liquor, comprising the steps of: a. separating the lignosulfonate precursor and providing a solution having at least 5 wt.%, preferably at least 10 wt.%, of lignosulfonate precursor, comprising the filtration of constituents having a particle diameter of less than 1 µm, in particular less than 100 nm, and the removal of low-molecular-weight constituents, in particular salts and low-molecular-weight organic compounds, preferably constituents having a molecular weight of less than 500 Da; b. adding a radical-forming enzyme and gassing the lignosulfonate precursor solution with oxygen in order to form polymerizable lignosulfonate radicals, oxygen being added as gas together with an admixture of at most 10 vol.%, preferably at most 5 vol.%, of other gases; and c. polymerizing the lignosulfonate precursor. The invention also relates to a water-insoluble lignosulfonate polymer according to the invention, to a water storage means, and to a growth substrate containing the lignosulfonate polymer according to the invention.
36 - Services financiers, assurances et affaires immobilières
38 - Services de télécommunications
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Rental of office space; Rental of laboratory space. Providing access to databases; Providing of access to webpages in an electronic information network relating to the networking and support of students; Message sending. University services; Care and development of scientists by means of research, learning and studies; Organising, Coordination and provision of information, Services for shows, Tuition, talks, Information days; Promotion of entrepreneurial thinking and acting to universities; Mediating practice-oriented vocational qualifications for students and teachers; Promotion of awareness for company formation being a career option for students and teachers.
42.
METHOD FOR IMMOBILIZING MOLECULES ON A CELLULOSIC MATERIAL
The present invention relates to a method for covalently binding at least one amino acid, at least one peptide and/or at least one polypeptide to a cellulosic material comprising cellulose and/or cellulose derivatives comprising free hydroxyl groups comprising the steps of a) subjecting the cellulosic material to an aqueous solution, ionic liquids, deep eutectic solvents, organic solvents or mixtures, comprising at least one oxidizing agent and b) binding said at least one amino acid, at least one peptide and/or at least one polypeptide to said cellulosic material.
The invention relates to a composition comprising one or more inhibitors capable of inhibiting at least two of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and lipoxygenase or a composition comprising one or more inhibitors capable of inhibiting an enzyme with arachidonate-Co A ligase activity, specifically long-chain-fatty-acid-Co A ligase (ACSL) 1, ACSL3, ACSL4, ACSL5, ACSL6, SLC27A2 or ACSBG2, or a combination thereof for use in selectively eliminating senescent cells. The invention further relates to an in vitro method of identifying senescent cells in a subject and to a method of identifying candidate compounds for the selective elimination of senescent cells.
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61K 31/403 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil condensés avec des carbocycles, p. ex. carbazole
A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
A61K 31/616 - Acide salicyliqueSes dérivés ayant le groupe hydroxyle en position 2 estérifié, p. ex. acide salicylsulfurique par des acides carboxyliques, p. ex. acide acétylsalicylique
Disclosed is a group of chimeric antigen receptors (CARs) consisting of two, three or four CAR molecules, wherein each member of the group of CARs is different in its amino acid sequence from one another, and wherein each of the CAR molecules of the group comprise at least a transmembrane domain and an ectodomain, wherein the ectodomain comprises one or two antigen binding moieties and/or one or two binding sites to which other polypeptides each comprising at least an antigen binding moiety are able to bind; wherein the ectodomain of each CAR molecule of the group in its prevalent conformation is free of cysteine amino acid moieties which are able to form intermolecular disulphide bonds with other CAR molecules of the group, respectively, and wherein each CAR molecule of the group comprises at least one heterodimerization domain.
Disclosed is agroup of chimeric antigen receptors (CARs) consisting of two, three or four CAR molecules, wherein the members of the group of CARs can be different or identical in their amino acid sequences to one another, and wherein each of the CAR molecules of the group comprise at least a transmembrane domain and an ectodomain comprising either an antigen binding moiety or a binding site to which another polypeptide is able to bind, wherein the another polypeptide comprises an antigen binding moiety; wherein each CAR molecule of the group comprises at least one dimerization domain, wherein this dimerization of a pair of dimerization domains is either induced by a regulating molecule and optionally reduced by another regulating molecule, or occurs in the absence of a regulating molecule and is reduced by a regulating molecule, and wherein the ectodomain of each CAR molecule of the group in its prevalent conformation is free of cysteine amino acid moieties which are able to form intermolecular disulphide bonds with other CAR molecules of the group, respectively, and wherein the antigen binding moieties of the CAR molecules of the group and of the other polypeptides being able to bind to the CAR molecules of the group are either specific for one target antigen or for a non-covalent or a covalent complex of different target antigens.
123456789101234567891010 is I or M, wherein the proteolytic activity of the at least one serine protease in the genetically modified plant or plant cell is reduced compared to its activity in the wild- type plant or plant cell, wherein the genetically modified plant or plant cell comprises at least one exogenous nucleic acid molecule encoding for at least one protein or polypeptide of interest.
The invention relate to assembly which is formed as a self-supporting composite ceiling construction extending along at least one main extension-direction (1), comprising a first load-bearing layer (2) of an armoured and cured casting compound (3) that extends along the main extension direction (1) and, when loaded as intended, is loaded in compression, a second load-bearing layer (4) of at least one wooden board that extends at least along the main extension direction (1) and, when loaded as intended, is loaded in tension, wherein the first load-bearing layer (2) extends at a distance from the second load-bearing layer (4), and wherein a hollow space (6) between the first load-bearing layer (2) and the second load-bearing layer (4) is kept free.
E04B 5/19 - Structures de planchers partiellement formées sur place comportant des nervures de renforcement ou autres conformations semblables à des poutres entièrement coulées entre des éléments de remplissage les éléments de remplissage jouant le rôle de coffrages permanents auto-portants
E04B 5/26 - Structures de planchers partiellement formées sur place avec des nervures de renforcement ou autres conformations semblables à des poutres totalement ou partiellement préfabriquées avec des éléments de remplissage entre les poutres
E04B 5/40 - Structures de planchers entièrement coulées sur place avec ou sans éléments de coffrage ou armatures avec des éléments de coffrage faisant partie du plancher avec des coffrages en forme de dalles servant en même temps d'armaturesDalles de coffrage avec armatures se prolongeant latéralement à l'extérieur de l'élément avec des plaques-coffrages métalliques
E04B 5/43 - Structures de planchers de conception particulièreCaractéristiques relatives à la stabilité élastiqueStructures de planchers spécialement conçus pour reposer uniquement sur des colonnes, p. ex. planchers-champignons
48.
DUAL VECTOR SYSTEM FOR IMPROVED PRODUCTION OF PROTEINS IN ANIMAL CELLS
The present invention refers to a dual vector system for production of one or more recombinant proteins in cells of insect origin comprising a first viral vector comprising a T7 promoter operably linked to a targeting sequence comprising a non-coding sequence and which expression can suppress one or more proteins essential for virus production, followed by a T7 termination sequence, and a second viral vector comprising a promoter operably linked to a T7 RNA polymerase encoding sequence, and at least one gene sequence located on the first and/or second vector encoding one or more recombinant proteins of interest. The invention further refers to recombinant insect cells comprising the dual vector system and methods for producing recombinant proteins using said dual vector system.
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G03H 1/08 - Procédés ou appareils pour produire des hologrammes pour faire des hologrammes synthétiques
G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques
G03H 1/04 - Procédés ou appareils pour produire des hologrammes
50.
PRODUCTS FOR THERAPY OF A MUSCULOSKELETAL CONDITION AND METHODS FOR THEIR PRODUCTION
Summary The present invention provides a method for obtaining a fraction of a fetal cell culture supernatant, comprising the steps of obtaining a cell-containing sample of tissue (such as cartilage) or (cord-)blood or bone marrow from a non-human mammalian fetus, culturing the sample in a liquid cell culture medium, thereby obtaining a cell culture with a liquid supernatant, and isolating a fraction from the supernatant. Furthermore, a fraction obtainable by this method is provided. A pharmaceutical composition comprising this fraction is also provided, preferably for use in therapy, such as for use in a prevention or treatment of osteoarthritis, arthritis, tendinitis, tendinopathy, cartilage injury, tendon injury, rheumatoid arthritis, discospondylitis, meniscus injury, desmitis, desmopathy, intervertebral disc injuries, degenerative disease of intervertebral discs, reperfusion injury, wounds or inflammatory disease.
Disclosed is a ligand regulated protein-protein interaction system based on a lipocalin-fold molecule comprising: (a) a lipocalin-fold molecule (b) a lipocalin-fold ligand with a low molecular weight of 1500 Da or below, and (c) a lipocalin-fold binding interaction partner, wherein the lipocalin-fold molecule can bind to the lipocalin- fold ligand; and wherein the lipocalin-fold molecule bound to the lipocalin-fold ligand binds to the lipocalin-fold binding interaction partner with an affinity which is at least 10-fold higher than the affinity of the lipocalin-fold molecule not bound to the lipocalin-fold ligand, and wherein the lipocalin-fold binding interaction partner is not a naturally occurring protein which has an affinity of <10 µM to any naturally occurring lipocalin-fold molecule in the presence of any lipocalin-fold ligand.
C07K 14/78 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine ou globuline insoluble à froid [CIG]
C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A specific antigen-binding member (ABM) comprising a specific antigen-binding moiety and an antibody Fc region comprising a CH2 domain, which is engineered for a cysteine substitution at position 108 and/or 113, wherein the numbering is according to the IMGT, and wherein the antibody Fc region comprises an antigen-binding CH3 domain or an antigen-binding Fc; and an ABM conjugate (ABMC) comprising the ABM and at least one heterologous molecule covalently conjugated to one or both of the cysteines at positions 108 and 113 of the CH2 domain.
C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/32 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des produits de traduction des oncogènes
A specific antigen-binding member (ABM) comprising a specific antigen-binding moiety and an antibody Fc region comprising a CH2 domain, which is engineered for a cysteine substitution at position 108 and/or 113, wherein numbering is according to the IMGT, and wherein the antibody Fc region does not comprise an antigen-binding CH3 domain; and an ABM conjugate (ABMC) comprising the ABM and at least one heterologous molecule covalently conjugated to one or both of the cysteines at positions 108 and 113 of the CH2 domain.
C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/32 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des produits de traduction des oncogènes
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer software (recorded programmes) in the field of scientific, human and industrial analysis and research; Downloadable electronic publications in the field of scientific, human and industrial analysis and research; Scientific, nautical, surveying, photographic, cinematographic, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; Apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; Apparatus for recording, transmission or reproduction of sound or images; Recording substrates [magnetic]; Phonograph records; CD discs; DVDs/ high density optical discs; USB flash drives; Calculators; Data processing equipment; Computers; Decorative magnets; Luminous signs. Printed matter, printed documents and publications relating to the field of education, teaching, training and instruction, books, newspapers, handbooks (manuals), periodicals, magazines, prospectuses, printed forms; Stationery instructional and teaching material (excluding apparatus), Tickets, Seals [stamps], Forms, printed, Posters, albums, Yearbooks and calendars, Geographical maps, Signboards of paper or cardboard, Envelopes [stationery], Paper sheets [stationery]; Pencils, fountain pens, Nibs, Pen rests, Pencil lead holders, Lithographs, photographs, Blueprints, Paper weights and post cards, Bags (envelopes, pouches) of paper or plastic, for packaging. Training, education, teaching, Education, educational information, Vocational guidance [education or training advice]; Cross-border cooperation in the fields of teaching and training; Organisation of competitions for teaching purposes, Educational examination; Academies (education), Correspondence courses, distance learning; Arranging and conducting of training workshops, colloquiums, conferences, congresses, exhibitions, seminars, symposiums and concerts, organisation of exhibitions for cultural or educational purposes, organisation of sports competitions; Publication of activity reports, books, magazines, CD-ROMs, publication of texts, other than publicity texts, online publication of electronic books and journals, lending of books; Practical training [demonstration]; Providing of sports, scientific and cultural facilities; Entertainment, providing recreation facilities, Entertainment information, Recreation information, Ticket agents services (entertainment), Production of shows, Holiday camp services (entertainment), Club services (entertainment or education), Planning (Party -) [entertainment], Sport camp services, Museum facilities (Providing -) [presentation, exhibitions], Videotape and DVD editing/ high density optical discs, Production of television and radio programs; Layout design, other than for advertising purposes, Film production services, Videotaping/ Digital versatile discs ( DVD's)/ high density optical discs, Library services, Mobile library services; Discotheques; Cinema presentations, Rental of motion pictures, Rental of sound recordings; Photographic reporting. Human and industrial scientific analysis and research in the following disciplines: the arts, plastic arts, foreign languages, foreign literature and civilisations, humanities, music, cultural and artistic activities, performing arts, visual arts, language and linguistics, philosophy, law, communication and information science and technology, marketing techniques, management of companies and administrations, economic and social administration, public administration, economics, management, economic science, accounting, checks and audits, finance, journalism, management, political science, social science, physical and sports education, geography, history, archaeology, psychology, sociology, science and techniques in the field of physical and sporting activities, theology, human resource management, anthropology, ethnology, demography, urban planning and landscaping, vocational training and science, chemistry, biology, physics, civil and industrial engineering, computing, mathematics, life sciences, earth sciences, astronomy and environmental science, agronomy, engineering science, astrophysics, bioinformatics, biophysics, biochemistry, geophysics, medical science, odontological science, health, medicine, dental surgery, pharmacy, logopaedics, orthoptics, acupuncture, maieutics; Cross-border cooperation in the field of human and industrial scientific research; Engineering, engineering drawing, Material testing, Research and development for others; Engineering services, Research in the field of environmental protection; Architecture, Interior decoration consultation, Urban planning, Construction drafting; Quality control; Computer system design, conversion of data or of documents from a physical carrier to an electronic carrier, development (design) of software, computer programming, database recovery, providing of search engines for the Internet; Authenticating works of art.
The present invention provides a method of detecting senescent cells or diagnosing cellular senescence in a subject wherein the level of one or more selected mi RNAs is quantified in a sample from said subject.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
57.
Compositions and methods for the diagnosis and treatment of bone fractures and disorders
The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected microRNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy individuals is indicative of the disorder.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
A61P 19/10 - Médicaments pour le traitement des troubles du squelette des maladies osseuses, p. ex. rachitisme, maladie de Paget de l'ostéoporose
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
A yeast comprising a nucleotide sequence expression system expressing a synthetic Calvin cycle comprising heterologous genes, which include at least a) a gene encoding an enzyme from the class of the ribulose-bisphosphate carboxylases (EC number: 4.1.1.39) (RuBisCO gene); and b) a gene encoding an enzyme from the class of the ribulose phosphate kinases (EC number: 2.7.1.19) (PRK gene), which is expressing; wherein the yeast optionally comprises a heterologous expression construct expressing a gene of interest (GOI) and/or wherein each of said RuBisCO gene and said PRK gene, is fused with a nucleotide sequence encoding a peroxisomal targeting signal (PTS).
Arrangement, separating device and separating method for wood dust particles, wherein the wood dust particles are or comprise wood fine dust particles with a size of smaller than 5 µm, in particular with a size of smaller than 1 µm, wherein the separating device comprises a flow channel (1), wherein the flow channel (1) is flowed through during operation by an air stream laden with the wood fine dust particles, wherein the flow channel (1) comprises an electrostatic charging section (2) for the at least partial electrostatic charging of the wood fine dust particles, wherein the flow channel (1) comprises, in or downstream of the electrostatic charging section (2), an agglomeration section (3) for the electrostatic agglomeration of wood fine dust particles to form wood dust agglomerates, wherein, downstream of the agglomeration section (3), there is positioned a mechanical separator (4) for separating off the wood dust agglomerates, and wherein, in the charging section (2), there is provided at least one, preferably multiple, charging element(s) (5) which have a triboelectric action and which serve for changing the electrical charge of multiple wood fine dust particles.
B03C 3/017 - Combinaison de la séparation par effet électrostatique avec d'autres procédés, non prévue ailleurs
B03C 3/145 - Installations alimentées en électricité de l'extérieur du type par voie sèche caractérisées par l'utilisation additionnelle d'effets mécaniques, p. ex. de la pesanteur de l'inertie
B03C 3/15 - Installations alimentées en électricité de l'extérieur du type par voie sèche caractérisées par l'utilisation additionnelle d'effets mécaniques, p. ex. de la pesanteur de forces centrifuges
B03C 3/155 - Installations alimentées en électricité de l'extérieur du type par voie sèche caractérisées par l'utilisation additionnelle d'effets mécaniques, p. ex. de la pesanteur de la filtration
B03C 3/30 - Installations fonctionnant sans alimentation en électricité, p. ex. utilisant des "électrets" dans lesquelles la charge électrostatique est créée par le passage des gaz, c.-à-d. triboélectricité
B03C 3/36 - Parties constitutives ou accessoires, ou leur fonctionnement commandant le débit de gaz ou de vapeurs
B01D 46/00 - Filtres ou procédés spécialement modifiés pour la séparation de particules dispersées dans des gaz ou des vapeurs
B27G 3/00 - Dispositifs pour enlever les écorces, copeaux, déchets ou sciures, spécialement conçus pour être utilisés avec les machines à bois ou dans les ateliers à travailler le bois
60.
METAL NANOPARTICLE SURFACE LIGAND REPLACEMENT METHOD
The invention relates to a method of producing inorganic nanoparticles with a polar surface, a) providing an inorganic nanoparticle with a coordinated organic ligand to the nanoparticles surface, b) providing a replacement salt comprising a replacement ion and a counterion, c) treating the inorganic nanoparticle with the coordinated organic ligand with the replacement salt in the presence of a chelating agent that complexes the counterion, thereby increasing the replacements ion's reactivity and replacing the organic ligand on the nanoparticle surface by the replacement ion which results in an inorganic nanoparticle with a polar surface; and a kit.
A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
The present invention relates to a plant or plant cell being capable to produce polysialylated glycoproteins comprising at least one recombinant nucleic acid sequence operably linked to a promoter, said recombinant nucleic acid sequence encoding for a polypeptide lacking a polysialyltransferase binding motif and comprising at least one glycosylation site.
C07K 14/46 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
62.
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF BONE FRACTURES AND DISORDERS
The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected microRNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy indivduals is indicative of the disorder.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
63.
Compositions and methods for the diagnosis and treatment of bone fractures and disorders
The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected micro RNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy individuals is indicative of the disorder.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
The invention provides a method of preparing a vesicular particle having at least in part a lipid and/or polymeric membrane that is a barrier between the interior and exterior of said vesicular particle, wherein said membrane comprises at least one inorganic core nanoparticle embedded in said membrane, said method comprises the steps of i)providing a first dispersion with one or more inorganic core particles having a hydrophobic dispersant shell, in a solution of membrane forming lipids and/or polymers, in a non-aqueous solvent; and ii)introducing the first dispersion into a non-solvent for the membrane forming lipids and/or polymers, wherein the volume of the non-solvent exceeds the volume of the first dispersion, thereby forming the vesicular particles;the produced particle preparations and their uses.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
Provided herein are influenza virus mutated hemagglutinin polypeptides, including compositions comprising the same, vaccines comprising the same and methods of their use.
The present invention relates to a nucleic acid molecule encoding: a) a modified tyrosylprotein sulfotransferase of a wildtype tyrosylprotein sulfotransferase, wherein the cytoplasmic transmembrane stem (CTS) region of the wild-type tyrosylprotein sulfotransferase is replaced by a heterologous CTS region, or b) a fusion protein comprising a catalytically active fragment of a tyrosylprotein sulfotransferase fused to a heterologous CTS region.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Consultancy services relating to environmental planning; Consultancy relating to laboratory testing; Consultancy relating to computer database programs; Consultancy in the field of security software; Consultancy services relating to computer networks; Architectural consultation; Consultancy services relating to marine surveying; Consultancy services relating to marine surveying; Advisory services relating to biochemistry; Advisory services relating to building design; Advisory services relating to design engineering; Advisory services relating to planning applications; Architectural consultation; Advisory services relating to product testing; Consultancy services relating to geophysics; Consultancy services relating to nuclear engineering; Information technology [IT] consultancy; Technical consultancy services relating to electrocardiograms; Engineering consultancy relating to testing; Engineering consultancy relating to design; Town planning consultancy services; Forensic advice relating to marine accidents; Professional consulting services and advice about agricultural chemistry; Professional consultancy relating to architecture; Bacteriological consultation and research; Technical advice relating to safety; Professional consultancy relating to computer security; Engineering consultancy relating to data-processing; Information technology consulting; Professional advisory services relating to computer hardware; Professional advisory services relating to computers; Advisory services relating to technological research; Advisory services relating to computer based information systems; Advisory services relating to the use of energy; Advisory services relating to scientific research; Advisory services relating to chemical reagents; Consultancy relating to software maintenance; Advisory services relating to gene therapy research; Consultancy services relating to technological research; Technical consultancy services relating to marine engineering; Consultancy relating to geological surveys; Technical consultancy services relating to structural engineering; Technical consultancy services relating to civil engineering; Technical advice relating to fire prevention; Consultation services relating to computer systems; Professional consultancy relating to the conservation of energy; Consultation services relating to architectural planning; Consultation services relating to interior design; Consultancy with regard to webpage design; Consultancy services relating to quality control; Provision of technical consultancy to the oil refining industry; Provision of technical consultancy to the shipping industry; Consultancy services relating to geographical planning; Design services; IT services; Testing, authentication and quality control; Architectural design services relating to exhibitions; Architectural design for exterior decoration; Architectural design for town planning; Architectural design for interior decoration; Architectural services for the design of office facilities; Architectural services for the design of commercial buildings; Architectural services for the design of industrial buildings; Design services for architecture; Building design services; Design of engineering works for the prevention of inundation of land by flood water; Design of engineering works for the prevention of inundation of buildings by flood water; Building design services; Consultancy relating to selection of furnishing fabrics [interior design]; Consultancy relating to selection of curtaining [interior design]; Consultancy relating to selection of loose covers for furniture [interior design]; Consultancy relating to the design of packaging; Advice relating to the design of computer hardware; Shopfitting design consultancy services; Web site design consultancy; Advisory services relating to the design of aquaria; Advisory services relating to interior design; Advisory services relating to computer hardware design; Advisory services relating to computer systems design; Ship design consultancy services; Office layout design services; Office furniture design; Computer design services; Computer aided design for manufacturing operations; Computer aided design services relating to architecture; Computer-aided design of video graphics; Computer aided design services relating to building projects; Computer aided part and mould design services; Computer assisted engineering design services; Computer aided graphic design; Design for others in the field of clothing; Computer graphics services; Database design and development; Animation design for others; Design services for display systems for presentation purposes; Design services for display systems for exhibition; Design services for display systems for promotional purposes; Design of equipment for the transportation of freight; Automotive design; Design of clothing, footwear and headgear; Design of lighting systems; Design of board-games; Brochure design; Design of computer databases; Design of printed material; Computer system design; Design of vehicles and vehicle parts and components; Design of graphics and of livery for corporate identity; Design of homepages and websites; Design of information systems relating to management; Design of headgear; Design of motor vehicles; Design of land vehicles; Design of shops; Design services relating to model making for play purposes; Design services relating to model making for entertainment purposes; Design of prostheses; Design services relating to model making for exhibition purposes; Design of rail vehicles; Jewellery design services; Design of specialist machinery for use in making equipment for lighting; Design of carpet tiles; Design services relating to furnishing fabrics; Design services relating to shop displays; Design services relating to the publication of documents; Graphic art design; Design services for parts of motor vehicles; Design services relating to the creation of elementary cells; Design services relating to the creation of masks; Design services relating to the installation of baths; Design services relating to the installation of sanitary fittings; Design services relating to window graphics; Design services relating to the reproduction of documents; Design services relating to interior decorating for offices; Design services relating to interior decorating for homes; Industrial design; Art work design; Interior and exterior design services; Design of interior decor; Retail design services; Interior design services and information and advisory services relating thereto; Dress designing; Footwear design services; Packaging design; Services for the planning [design] of offices; Services for the planning [design] of catering establishments; Services for the planning [design] of hotels; Services for the planning [design] of hospitals; Services for the planning [design] of public houses; Interior design services incorporating the principles of feng shui; Diagnostic testing for industrial lubricants; Design feasibility studies; Consultancy services for designing information systems; Providing a website featuring information in the field of interior design; Furnishing design services for the interiors of buildings; Clothing design services; Development and design of digital sound and image carriers; Development of hardware for audio and video operators; Constructing an internet platform for electronic commerce; Development of prostheses; Website development services; Development, design and updating of home pages; Design of three dimensional displays; Design of mathematical models; Design of seagoing vessels; Design, creation, hosting and maintenance of internet sites for third parties; Architectural and urban planning services; Engineering services; Medical and pharmacological research services; Natural science services; Surveying and exploration; Marine chart updating; Analysis of stream water quality; Analysis of the mode of action of chemical combinations on animals; Analysis of telecommunication signals; Analysis of oil soakings; Analytical services relating to the development of oil fields; Analytical services utilizing radar; Analytical and testing services for oil workings; Analytical laboratory services; Archaeological exploration; Archaeological research; Recording data relating to energy consumption in buildings; Preparation of engineering drawings; Measurement evaluation services; Provision of information, advice and consultancy in relation to carbon offsetting; Building research services; Computer technology consultancy; Consultancy in the field of energy-saving; Consultancy relating to filtration technology; Telecommunications technology consultancy; Computer aided industrial research services; Computer aided industrial analysis services; Computer aided diagnostic testing services; Chemical technological research; Blood analysis services; Air flow biochemical analysis services; Blood analysis services for scientific research purposes; Pyrotechnics assessment services; Providing online information about industrial analysis and research services; Providing on-line information in the field of technological research from a computer database or the Internet; Providing information about industrial analysis and research services; Providing science technology information; Control technology consulting services; Consultancy relating to technological services in the field of power and energy supply; Provision of information relating to technological research; Advisory services relating to energy efficiency; Consultancy services relating to geotechnics; Consultancy relating to membrane technology; Advisory services relating to vehicle noise reduction; Conducting industrial experiments; Air flow measurement services; Laboratory testing; Conducting research and technical project studies relating to the use of natural energy; Blasting vibration measurement; Blasting vibration analysis; DNA testing services to determine paternity (laboratory services); Analysis and testing for oil workings; Analysis of the structural behaviour of buildings; Technological studies relating to machine tools; Conducting of technical feasibility studies; Technical research projects and studies; Technical data analysis services; Conducting industrial tests; Computerised food analysis services; Air flow acoustic measurement services; Services for assessing the efficiency of industrial chemicals; Technical writing for others; Services for the design of maps; Chemical engineering; Research laboratories; Computer aided scientific analysis services; Computer aided scientific research services; Draughtsman's services; Measurement services; Scientific testing services; Calibration [measuring]; Development and test of chemical production methods; Component development for internal combustion engines; Development of construction projects; Development of coatings for metals; Development of coatings for non-metals; Development of energy and power management systems; Development of vehicles; Development of aircraft; Development of industrial machinery; Development of engines; Development of measuring probes for biotechnological applications; Development of testing apparatus for electrical wires; Development of testing methods; Services for the development of methods of testing; Development of power assemblies; Development of machining techniques; Design and development of medical technology; Drug discovery services; Design and development of energy distribution networks; Design and development of regenerative energy generation systems; Professional consultancy relating to marine technology; Expert reporting services relating to technology; Provision of scientific information; Services for the provision of technological information; Provision of technical information relating to the manufacture of paper; Provision of information relating to scientific research; Preparation of technical studies; Preparation of project analysis studies; Preparation of technical manuals; Preparation of reports relating to commissioning of nuclear units; Creation of control programs for automated measurement, assembly, adjustment, and related visualisation; Expert opinion relating to technology; Preparation of maps in digital form; Preparation of reports relating to scientific research; Preparation of reports relating to technical research; Creation of GPS maps; Preparation of technological reports; Preparation of scientific reports; Compilation of scientific information; Tyre research services; Oil well logging and testing; Drafting and development of photovoltaic systems; Drafting of construction plans for recreation premises; Research of fisheries; Research relating to security; Research on building construction or city planning; Research in the field of communications technology; Research in instrumentation; Research in the field of energy; Research relating to metals; Research relating to industrial machinery; Research relating to waste analysis; Research in the field of welding; Cell separation research services; Research in measurement technology; Research relating to insecticides; Research in the area of semiconductor processing technology; Research in the field of hair care; Electrical safety research; Research relating to demographics; Research relating to construction machinery; Research in engine construction; Forensic advice relating to explosions; Professional advisory services relating to food technology; Professional consulting services and advice about agricultural chemistry; Professional consultancy relating to energy efficiency in buildings; Integrated scientific research on vermin for greenhouses and harvest crops; Information services relating to the safety of manures used in horticulture; Development of industrial processes; Industrial process research; Industrial research; Industrial analysis and research services in the field of chemistry; Industrial analysis and research services relating to automobile tires; Industrial analysis services; Handwriting analysis [graphology]; Basic and clinical research in the field of respiratory science and medicine; Genetic research; Photogrammetry services; Provision of research services; Research and development in the field of biotechnology; Research and development services relating to fertilisers; Mechanical research; Cosmetic research; Research and development of new products for third parties in the field of plastic materials; Research of livestock breeding; Research and development services in the field of antibodies; Research and development services relating to automobile tires; Mechanical research in the field of motor sports; Mathematical research services; Machine condition monitoring; Airborne remote monitoring relating to scientific explorations; Airborne remote sensing relating to scientific explorations; Analysing of air in building environments; Food sanitation consultation; Research of foodstuffs; Laboratory research in the field of cosmetics; Agricultural research; Laboratory services for agricultural research; Laboratory services for soil analysis; Laboratory services for analytical testing; Laboratory services; Forensic advice relating to damage assessment; Calibration of instruments; Calibration services relating to electronic apparatus; Calibration services relating to analytical apparatus; Cartography services; Mapping services; Construction drafting; Monitoring of building structures; Design and development of electronic data security systems; Cosmetics research for others; Quality evaluation of standing timber; Tyre analysis services; Conducting sampling and analysis services to check for contamination; Conducting sampling and analysis services to assess pollution levels; Safety technology services relating to land vehicles; Professional consultancy relating to fluid dynamics; Technological analysis relating to energy and power needs of others; Providing technological information about environmentally-conscious and green innovations; Technical consultancy regarding the field of road cutting technology; Technical consultancy in relation to the production of semiconductors; Technical advice relating to the manufacture of tyres; Oenology services; Evaluation of wool (Quality -); Testing of telecommunication signals; Programming of electronic control systems; Product research; Technical project planning; Oil spill contingency planning services; Radon detecting; Measuring variables associated with the drilling of boreholes; Measuring variables associated with the directional steering of boreholes; Greenhouse gas emission measuring and analysis; Measuring the environment within civil engineering structures; Air flow particle counting services; Monitoring of contaminated land for gas; Provision of technical consultancy to the petrochemical industry; Technical consultation in the field of aerospace engineering; Technical consulting in the field of pollution detection; Technical advice relating to pollution damage; Technical advice in connection with energy-saving measures; Technical consultancy in relation to the technical research in the field of food and beverages; Technical consultancy in relation to research services relating to foods and dietary supplements; Technical research in the field of aeronautics; Technical research relating to automatic identification systems; Technical research relating to automatic numbering systems; Technical inspection services; Technical planning and consulting in the field of light engineering; Technical planning and technical project management for the development of lighting equipment; Technical project studies; Technical project studies in the field of construction; Technical project studies in the field of carbon offsetting; Monitoring of events which influence the environment within civil engineering structures; Technological analysis services; Technological consultancy in the fields of energy production and use; Technological services relating to manufacture; Technological services relating to rheology; Technological services relating to rheometrics; Technological services and design relating thereto; Cell separation technology services; Technological services and research relating thereto; Research relating to technology; Technological research for the building construction industry; Energy auditing; Technical drawing; Monitoring of activities which influence the environment within buildings; Monitoring of activities which influence the environment within civil engineering structures; Monitoring of events which influence the environment within buildings; Technical design and planning of telecommunications equipment; Technical design and planning of pipelines for gas, water and waste water; Technical design and planning of heating installations; Technical design and planning of sewerage systems; Technical design and planning of power stations; Technical design and planning of telecommunications networks; Technological consultation services; Technological consulting services in the field of alternative energy generation; Technical design and planning of water purification plants; Non-medical, ultrasound imaging services; Measuring the environment within buildings; Technical writing; Rental of laboratory apparatus and instruments; Rental of measuring apparatus; Rental of calculators; Rental of time-recording apparatus; Rental of time keeping equipment; Leasing of scientific instruments; Contract research services relating to molecular sciences; Preparation of technological research reports; Water analysis; Prediction measurement of steady state exhaust emissions; Information services relating to the safety of fertilisers used in forestry; Information services relating to the safety of fertilisers used in agriculture; Information services relating to the safety of fertilisers used in horticulture; Professional consultancy relating to the science of ergonomics; Advisory services relating to science; Services for assessing the efficiency of agricultural chemicals; Veterinary laboratory services; Monitoring the quality control of seismic procedures; Services for monitoring industrial processes; Monitoring of telecommunication signals; Monitoring of audio warning signals; Monitoring of contaminated land; Scientific services and design relating thereto; Scientific services and research relating thereto; Research services; Scientific research relating to cosmetics; Scientific research for medical purposes; Scientific research and analysis; Scientific research relating to hair care preparations; Laboratory (Scientific -) services; Scientific and industrial research; Scientific and industrial research in particular in the field of electricity; Condition monitoring relating to fluids; Condition monitoring relating to greases; Condition monitoring relating to lubricants; Condition monitoring relating to oils; Civil engineering drawing services; Engineering drawing; Architectural and engineering services; Civil engineering planning services; Telecommunications engineering consultancy; Civil engineering consultancy; Advisory services relating to industrial engineering; Biochemical engineering services; Electrical engineering services; Engineering services for others; Engineering drawing; Engineering consultancy services; Civil engineering; Levee engineering; Conducting technical project studies for construction projects; Engineering project studies; Engineering testing; Design of engineered building systems; Design of engineering works for flood prevention; Design services relating to civil engineering; Preparation of technical reports; Conducting engineering surveys; Engineering feasibility studies; Provision of engineering reports; Preparation of engineering reports; Provision of information relating to industrial engineering; Research relating to mechanical engineering; Engineering services for applications on large and medium-sized computer systems; Engineering services relating to computers; Engineering services relating to computer programming; Engineering services relating to information technology; Engineering services relating to robotics; Engineering services relating to automatic data processing; Engineering services relating to the design of communications systems; Engineering services relating to machine tool design; Engineering services relating to metal forming systems; Engineering services relating to metal handling systems; Engineering services for the design of structures; Engineering services for the analysis of structures; Mechanical engineering; Nuclear engineering services; Explosives engineering services; Engineering services relating to data processing; Engineering services relating to data processing technology; Engineering services relating to the design of electronic systems; Engineering services for the design of machinery; Engineering services for the analysis of machinery; Structural engineering services; Telecommunications engineering; Engineering services related to integrated circuit diagnostics; Engineering services for the gas industry; Engineering services in the field of building technology; Engineering services relating to gas transport and supply systems; Engineering services in the field of energy technology; Engineering services relating to energy supply systems; Engineering services in the field of motive power; Engineering services in the field of communications technology; Engineering services in the field of electrical power and natural gas production; Engineering services in the field of environmental technology; Engineering research; Engineering and computer-aided engineering services; Technological engineering analysis; Engineering consultancy relating to manufacture; Technical consulting in the field of environmental engineering; Technical engineering; Engineering surveying; Technical project planning in the field of engineering; Industrial testing of engineering works; Engineering project management services; Technological advisory services relating to machine engineering analysis; Preparation of reports relating to technical project studies for construction projects; Recordal of seismic data; Consultancy services relating to geology; Consultancy services relating to hydrogeology; Consultation in environment protection; Advisory services relating to environmental pollution; Advisory services relating to the safety of the environment; Consultancy services relating to research in the field of environmental protection; Providing weather information; Provision of scientific information, advice and consultancy in relation to carbon offsetting; Environmental hazard assessment; Soil analysing services; Well logging; Environmental testing; Environmental testing of vibration; Compilation of information relating to environmental conditions; Collection of information relating to the environment; Compilation of environmental information; Environmental surveys; Provision of geographical information; Provision of meteorological information for shipping; Provision of weather information via the telephone; Meteorological information; Provision of weather information for shipping; Research relating to mineral resources; Research in the field of environmental conservation; Research in the field of climate change; Research in the reduction of carbon emissions; Geological probing of building plots; Geological testing of building plots; Geophysical research services; Hydrological research; Cloud seeding; Airborne remote sensing relating to environmental explorations; Airborne remote monitoring relating to environmental explorations; Measuring of earth samples; Meteorological research; Meteorological forecasting; Oceanographic research services; Sampling for contamination; Sampling for pollution; Testing of chemicals; Technical consultancy in the field of environmental science; Technological consultancy in the field of geology; Environmental consultancy services; Environmental testing of exhaust emissions; Environmental testing of noise pollution; Advisory services relating to pollution control; Research in the field of environmental protection; Environmental monitoring of waste storage areas; Environmental assessment services; Environmental monitoring of waste treatment areas; Collection of information relating to seismology; Weather forecasting; Collection of information relating to hydrology; Collection of information relating to meteorology; Collection of information relating to oceanography; Scientific research relating to ecology; Earth science services; Agrochemical research services; Analysis in the field of molecular biology; Analytical services relating to the determination of the chemical content of liquids; Analytical services relating to the determination of the bacterial content of liquids; Analytical services relating to the assessment of the chemical content of liquids; Analytical services relating to the assessment of the bacterial content of liquids; Analytical services relating to the testing of the chemical content of liquids; Analytical services relating to the testing of the bacterial content of liquids; Astronomy consultation; Bacteriological analysis; Bacteriological research and analysis; Bacteriological research and testing; Working on and evaluation of chemical syntheses; Consultation in the field of physics; Consultancy relating to biotechnology; Consultation services relating to physics; Provision of information concerning research and technical project studies relating to the use of natural energy; Providing scientific information in the field of global warming; Providing scientific information in the field of climate change; Classification of minerals; Chemical research and analysis services; Chemical services relating to mineralogy; Chemical services relating to ores; Chemistry consultation; Chemical analysis services for use in design; Chemical analysis services for use in evaluation; Biotechnological research relating to industry; Biotechnological research relating to the petroleum industry; Biotechnological research relating to horticulture; Biotechnological research relating to enzymatic synthesis; Biotechnological research relating to agriculture; Biotechnological research relating to livestock; Research relating to biotechnology; Biotechnology research for determining the neuronal survival of molecules in animal models; Biomedical research services; Biological laboratory services; Biological research, clinical research and medical research; Biological research and analysis; Biological research; Biological development services; Biological analysis; Biochemistry services; Biochemical analysis; Biochemical research and analysis; Biochemistry research services; Chemical laboratories; Computerised information services relating to geophysical measurement; DNA screening for scientific research purposes; Chemist services; Physics [research]; Metallurgical laboratory services; Services of a chemical and/or biological laboratory; Biological research laboratory services; Chemical research laboratory services; Biological cloning services; Biotechnology testing; Chemical analysis; Chemical analysis services for use in the testing of material; Chemical analysis services for use in gemological analysis; Chemical analysis of land; Chemical analytical examinations; Microbiological testing; Metallurgical analysis; Working on and evaluation of chemical analyses; Behavioural analysis of chemicals; Analysis of the structural behaviour of building materials; Analysis of used machine oils; Analysis of polymeric coatings; Analysis of paints; Analysis of geological samples; Structural and functional analysis of genomes; Genetic testing of laboratory animals for research purposes; Toxicity analysis; Analysis of materials; Conducting of scientific studies; Compilation of toxicological information; Feasibility studies relating to material analysis; Genetic fingerprinting; Preparation of reports in the biotechnology field; Preparation of reports relating to chemical research; Issuing of toxicological information; Information on the subject of scientific research in the field of biochemistry and biotechnology; Provision of scientific information relating to chemicals; Provision of scientific information relating to the chemical industry; Research relating to molecular sciences; Research relating to plant breeding; Research relating to animal husbandry; Research relating to cultivation in horticulture; Research relating to cultivation in agriculture; Research relating to fine chemicals; Research relating to speciality chemicals; Research in the field of gene therapy; Research relating to the production of seeds; Research and development services in the field of gene expression systems; Research and development services in connection with physics; Research and development services in the field of antibody technology; Research and development services relating to vaccines; Research and development in the pharmaceutical and biotechnology fields; Research and development services in the field of bacteriology; Research and development services in the field of chemistry; Research and development services in the field of immunohistology; Research and development services in the field of immunology; Research and development services in the field of cytology; Biochemical research and development; Bacteriological research; Chemical research; Research and development in the field of diagnostic preparations; Research and development in the field of microorganisms and cells; Laboratory research in the field of chemistry; Genetic engineering services; Stem cell research; Assessing chemical information in relation to hazards; Assessing chemical information in relation to risks; Assessing toxicological information in relation to hazards; Assessing toxicological information in relation to risks; Environmental monitoring services; Laboratory testing of materials; Animal semen testing services for research purposes; Preparation of biological samples for analysis in research laboratories; Preparation of biological samples for testing and analysis in research laboratories; Preparation of biological samples for research purposes; Preparation of immunohistological samples for analysis in research laboratories; Scientific analysis; Information services relating to the safety of chemicals used in horticulture; Information services relating to the safety of chemicals used in forestry; Information services relating to the safety of chemicals used in agriculture; Scientific services relating to the isolation and cultivation of human tissues and cells; Scientific research relating to bacteriology; Scientific research relating to genetics; Scientific research relating to biology; Scientific research relating to chemistry; Scientific research in the field of genetics and genetic engineering; Scientific research relating to genetics of plants.
The invention relates to a flood protection system (11) for preventing a body of water from overflowing in the event of a flood level, which flood protection system comprises a foundation (36) and at least one panel (38), which is supported on the foundation (36) in such a way that at least one panel can pivot about a pivot axis (40). The panel (38) has a water retention wing (50) and a lifting wing (60), which are arranged on opposite sides of the pivot axis (40). A water chamber (70) communicates with the body of water by means of an overflow (25), the level of which defines the flood level, only if the water level (WSP) of the body of water reaches or exceeds the flood level. At least some segments of a top side (61) of the lifting wing (60) are arranged in the water chamber (70). By means of water running into the water chamber (70) via the overflow (25), hydrostatic pressure on the lifting wing (60) can be built up, which hydrostatic pressure presses the lifting wing into the interior of the water chamber (70) and thereby pivots the water retention wing (50) about the pivot axis (40) from a lowered position to a raised position.
A domain-exchanged immunoglobulin which is half-life extended through incorporation of a heterologous CH3HET/CH3HET dimer, wherein CH3HET is a heterologous CH3 domain and said CH3HET/CH3HET dimer comprises a first CH3HET incorporated into the heavy chain (HC) and forming a dimer with a second CH3HET incorporated into the light chain (LC) of said immunoglobulin at least through contact of a beta-sheet region of the first and second CH3HET domains, wherein said first and/or second CH3HET immunoglobulin domain is N-terminally linked to an immunoglobulin domain different from CH2 and incorporates a pH dependent FcRn binding site.
The invention provides a method of producing inorganic core particles comprising a dispersant shell, comprising a dispersant molecule in a high surface covering density on the inorganic core, comprising the steps of providing an inorganic particle, ligating an organic linker onto an inorganic particle, thereby obtaining an inorganic core linker coated particle, providing a fluidized dispersant, preferably in form of a melt, suspension or solution, binding the fluidized dispersant to the organic linker, thereby obtaining the inorganic core particles comprising a dispersant shell, as well as particles obtainable by such a method.
A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected micro RNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy indivduals is indicative of the disorder.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
72.
Compositions for use in treating or diagnosing bone disorders and/or cardiovascular disorders
Compositions of an inhibitor of a polynucleotide for use in treating or preventing bone disorders such as osteoporosis, osteopenia, bone fracture, bone cancer, as well as impaired bone homeostasis. Preferred compounds to be used in these medical interventions are antagonistic compounds, like nucleic acid molecules, directed against miR-31 and derivatives thereof. Also, methods for diagnosing and compositions for use in diagnosing bone disorders. Compounds to be employed in these diagnostic methods and uses include compounds such as miR-31.
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
This application relates to methods for purification of proteins such as antibodies using a hydrophilic polymer (e.g., PEG), a fatty acid (e.g., caprylic acid), and / or another agent (e.g., calcium chloride).
The invention relates to compositions and methods for the treatment, prophylaxis and diagnosis of disorders associated with aberrant bone mineral density. More particularly, the invention relates to increasing Galectin-3 levels in mesenchymal stem cells to increase osteogenesis. Compositions comprising Galectin-3 or nucleic acids encoding Galectin-3 may be administered systemically or locally and are useful for the treatment of diseases like osteoporosis and for accelerating bone healing. The invention also relates to methods for diagnosing bone diseases, wherein the level of Galectin-3 is measured.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
75.
COMPOSITIONS CONTAINING GALECTIN-3 MODULATORS FOR THE TREATMENT OF BONE DISORDERS
The invention relates to compositions and methods for the treatment, prophylaxis and diagnosis of disorders associated with aberrant bone mineral density. More particularly, the invention relates to increasing Galectin-3 levels in mesenchymal stem cells to increase osteogenesis. Compositions comprising Galectin-3 or nucleic acids encoding Galectin-3 may be administered systemically or locally and are useful for the treatment of diseases like osteoporosis and for accelerating bone healing. The invention also relates to methods for diagnosing bone diseases, wherein the level of Galectin-3 is measured.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
The invention relates to an isolated waterproof polymeric nanomembrane comprising pores of different geometric shapes and of a controlled size between 10 and 1000 nm, which is larger than the thickness of the membrane, and a method of producing the same comprising the process steps a. Providing a sacrifice layer on a surface of a solid support; b. Providing a polymerized layer of less than 1000 nm thickness on the surface of the sacrifice layer, by depositing a mixture of a polymer or a polymer precursor with a geometrically undefined pore template which is larger than the thickness of the polymerized layer, optionally followed by polymerization and/or crosslinking; c. Removing the pore template to obtain the polymerized layer with a controlled pore size; and d. Removing the sacrifice layer, thereby separating the solid support from the polymerized layer.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
C08J 9/26 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par élimination d'une phase solide d'un objet ou d'une composition macromoléculaire, p. ex. par lessivage
77.
TRANSFORMED FUNGUS WITH VITAMIN K DEPENDENT ACTIVITY
The present invention provides a fungus cell transfected with exogenous nucleotide coding sequence of a gamma-carboxylase, a vitamin K reductase, and a vitamin K-dependent polypeptide, wherein the gamma-carboxylase and vitamin K reductase sequences lack an ER retention sequence endogenous to said fungus cell, preferably are free of any fungal ER retention leader sequence.
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
Guangzhou Institute of Biomedicine and Health (Chine)
Universitat fur Bodenkultur Wien (Autriche)
Inventeur(s)
Esteban, Miguel
Grillari, Johannes
Grillari, Regina
Pei, Duanqing
Zhou, Ting
Abrégé
Methods for generating iPSCs and differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCs or by direct reprogramming the urine cells.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12N 5/02 - Propagation de cellules individuelles ou de cellules en suspensionLeur conservationMilieux de culture à cet effet
Panels of mammalian cell samples, kits and methods of use thereof. The panels comprise samples or sets of samples of immortalized primary cells, obtained from different tissues and organs of healthy and/or diseased donors. The cell panels are useful in assays for testing effects of drug candidates, e.g. for activity and toxicity.
C40B 50/00 - Procédés de création de bibliothèques, p. ex. synthèse combinatoire
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
80.
RAW MILK PREPARATION FOR USE FOR PREVENTING OR TREATING ASTHMA AND OTHER ALLERGIC DISEASES IN INFANTS AND CHILDREN
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (Allemagne)
UNIVERSITÄT BASEL, VIZEREKTORAT FORSCHUNG (Suisse)
SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT (Suisse)
UNIVERSITÄT FÜR BODENKULTUR WIEN (Autriche)
Inventeur(s)
Von Mutius, Erika
Braun-Fahrländer, Charlotte
Kneifel, Wolfgang
Abrégé
Disclosed in the application is a raw milk preparation for use for treating or preventing childhood asthma and allergic diseases and methods of producing the raw milk preparation for use for treating or preventing childhood asthma and allergic diseases. Also disclosed is the use of the a raw milk preparation as nutritional supplement for a female human being during pregnancy, as a preparation for a planned pregnancy and/or during nursing of the infant or for an infant or child from birth to at least until completion of the 1st or 3rd year of age.
GUANGZHOU INSTITUTE OF BIOMEDICINE AND HEALTH (Chine)
Inventeur(s)
Esteban, Miguel
Grillari, Johannes
Grillari, Regina
Pei, Duanqing
Zhou, Ting
Abrégé
Methods for generating iPSCsand differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCsor by direct reprogramming the urine cells.
The invention refers to a method of producing a recombinant polypeptide of interest (POI) in a cell culture, comprising genetically engineering a eukaryotic cell line - to specifically cause prolongation of the G2+M cell cycle phase in a pre-culture phase, and - to produce the POI in a producing phase following the pre-culture phase, a high producer cell line and cell culture as well as a method of increasing the yield of a recombinant POI production in a cell culture.
The present invention relates to compositions comprising an inhibitor of a polynucleotide, said polynucleotide to be inhibited being capable of decreasing or suppressing expression of FZD3 (Frizzled-3) or a biologically active derivative thereof for use in treating or preventing bone disorders and/or cardiovascular disorders. Such bone disorders comprise, inter alia, osteoporosis, osteopenia, bone fracture, bone cancer, as well as impaired bone homeostasis. Cardiovascular diseases to be treated by the compounds of the present invention may be selected from the group consisting of infarction, stroke, hypertension, thrombosis, vascular stenosis, coronary syndromes, vascular dementia, heart failure, renal failure, stress-related cardiovascular disorders and atherosclerosis. Preferred compounds to be used in these medical interventions are antagonistic compounds, like nucleic acid molecules, directed against miR- 31 and derivatives thereof. Also, the present invention relates to methods for diagnosing and compositions for use in diagnosing bone disorders and/or cardiovascular disorders. Compounds to be employed in these diagnostic methods and uses may be compounds (like primers and probes) that are capable of detecting such a polynucleotide that is capable of decreasing or suppressing expression of FZD3 or a biologically active derivative thereof. miR-31 is provided herein as a polynucleotide that is capable of decreasing or suppressing expression of FZD3.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
A61P 19/08 - Médicaments pour le traitement des troubles du squelette des maladies osseuses, p. ex. rachitisme, maladie de Paget
A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
84.
PANELS OF IMMORTALIZED MAMMALIAN CELLS AND THEIR USE
Panels of mammalian cell samples, kits and methods of use thereof. The panels comprise samples or sets of samples of immortalized primary cells, obtained from different tissues and organs of healthy and/or diseased donors. The cell panels are useful in assays for testing effects of drug candidates, e.g. for activity and toxicity.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
85.
METHOD FOR DETERMINING POLYCYCLIC AROMATIC HYDROCARBON CONTAMINANT CONCENTRATION
The invention refers to the use of a device for determining PAH concentration in a solid state sample, which device comprises a) means for exposing the sample to diffuse reflectance infrared spectroscopy, b) detecting means for recording at least one spectroscopic parameter of infrared diffuse reflection of said sample, which is a signal obtained at one or more frequencies within a range of frequencies (+/- 10 cm-1) selected from the group consisting of 3000-3100 cm-1, 740, 777, 814, 842, 1430, 1510, 1600, 4055- 4056, 4642-4646, 5924, and 5951-5953 cm-1, and c) computing means for performing data analysis by correlating the at least one spectroscopic parameter with variables of a trained multivariate calibration model related to PAH concentrations, thereby obtaining prediction of PAH concentrations in the sample, and a method of determining a PAH concentration by diffuse reflectance infrared spectroscopy.
G01N 21/35 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge
G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
The invention relates to a method for producing substantially dendritic snow, comprising: a) feeding a flow of humid air (1) and a flow of cold air (9) into a substantially closed space in order to mix the two flows therein and thus to form an atmosphere supersaturated with water in the space; b) forming ice crystals and allowing snowflakes to grow from the supersaturated atmosphere within the substantially closed space, wherein the growing ice crystals and snowflakes are kept in a suspended state within the substantially closed space and allowed to grow for a predetermined time frame that is sufficient for obtaining snowflakes of a predefined size, wherein the suspended state is achieved in that the growing ice crystals and snowflakes are moved by the air flow on average along a substantially helical path, which causes a distribution of the snowflakes according to the size thereof along the substantially helical path; c) discharging the snowflakes having a predefined size after the predetermined time frame by means of a carrier air flow (3) through a discharge opening (7) of the substantially closed space.
F25C 3/04 - Procédés ou appareils spécialement adaptés à la production de glace ou de neige pour les sports d'hiver ou pour des loisirs similaires, p. ex. pour des installations sportivesProduction de neige artificielle pour les pistes de bobsleigh ou de skiProduction de neige artificielle
87.
N-GLYCAN CORE BETA-GALACTOSYLTRANSFERASE AND USES THEREOF
The present invention relates to new galactosyltransferases, nucleic acids encoding them, as well as recombinant vectors, host cells, antibodies, uses and methods relating thereto.
C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
The present invention relates to cellobiose dehydrogenases (CDH) having glucose oxidation activity at a pH of 7.4 or above, modifications to modify the pH dependency of the enzymes activity, uses for these CDHs, in particular electrode sensors and electrochemical cells.
The invention refers to a host cell line of a biotin prototrophic yeast capable of expressing a xenogene in a host cell culture, comprising a BIO1 gene, optionally one or more complementary BIO genes selected from the group consisting of BIO2, BIO3, BIO4 and BIO6, and a xenogene, a method of producing such a host cell line and a method of producing a product resulting from the expression of said xenogene.
The present invention relates to a method for removing cross-reactive carbohydrate determinant (CCD) specific antibodies from a sample comprising the steps of : - providing a sample comprising or suspected to comprise CCD specific antibodies, - contacting and incubating said sample with a solid support comprising at least one cross-reactive carbohydrate determinant, immobilised on its surface, and - removing said solid support from the sample.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
The present invention provides a method of expressing a plant Lewis-type β1, 3-galactosyltransferase in an organism comprising the step of providing the organism with a nucleic acid molecule comprising a sequence A which is defined as being selected from: a) a sequence according to SEQ ID NO: 1 with an open reading frame from base pair 1-1932, j) a sequence which is at least 50% identical with SEQ ID NO: 1, k) a sequence which hybridizes with SEQ ID NO: 1 under stringent conditions, or 1) a sequence which has degenerated to SEQ ID NO: 1 due to the genetic code, wherein the sequences a) to d) encode a plant protein having Lewis-type β1, 3-galactosyltransferase activity, or m) a sequence which is complementary to one of the sequences a) to d), and expressing a protein encoded by sequence A or if the organism comprises a sequence A in its wildtype form overexpressing a protein encoded by sequence A.
The present invention relates to a vector library comprising a multiplicity of different eukaryotic secretion vectors, wherein each vector comprises under the control of transcriptional and translational control sequences a gene encoding for an extracellular soluble fusion polypeptide which gene comprises a coding sequence for a scaffold polypeptide linked to variable coding sequences for a peptide, wherein said vectors comprise a nucleic acid coding for a secretory signal sequence linked to the gene coding for the fusion polypeptide.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C07K 1/00 - Procédés généraux de préparation de peptides
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
