A continuous-flow process is provided for separating at least two components from a mixture of components. The mixture is provided in a counter-current flow comprising a first phase flowing in an opposite direction with respect to a second phase, the first phase being immiscible with and/or separated from the second phase. A plurality of stages are provided along the counter-current flow for exchanging the at least two components between the phases. Each stage is associated with a partition coefficient for each or the component between the first and second phase, and a first-to-second-phase flow rate ratio. The counter-current flow comprises, for each of the at least one component, an accumulation region. The partition coefficient and/or the flow rate ratio of stages at opposite sides of the accumulation region are adapted for inducing, at each of said stages, a net flux of the component along the counter-current flow, such that the direction of said net flux is opposite for stages at opposite sides of the accumulation region points towards the accumulation region. The component can then be removed from the accumulation region and from the counter-current flow.
C22B 3/26 - Traitement ou purification de solutions, p. ex. de solutions obtenues par lixiviation par extraction liquide-liquide utilisant des composés organiques
2.
METHOD FOR OBTAINING POTATO WITH LOW SUGARS CONTENT BY SITE-DIRECTED NUCLEOTIDE SUBSTITUTION
The present invention relates to a method for obtaining potato with lower sugars content by site-directed nucleotide substitution, and also relates to a method for generating site- directed nucleotide substitution and fragment substitution.
C12N 9/26 - Hydrolases (3.) agissant sur les composés glycosyliques (3.2) agissant sur les liaisons alpha-glucosidiques-1, 4, p. ex. hyaluronidase, invertase, amylase
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
3.
METHOD FOR MANUFACTURING A MAGNETRON CAVITY FOR ATOMIC CLOCKS
A computer-assisted method for the dimensioning of a magnetron cavity for an atomic clock, in particular for a hydrogen maser, the cavity being substantially cylindrical and including at least two curved electrodes disposed along a circular arc and delimiting a substantially cylindrical space of predetermined radius r, the cavity also including a substantially cylindrical storage bulb of radius rB disposed in said space such that there is a radial interstice ei between the at least two electrodes and the storage bulb.
H03L 7/26 - Commande automatique de fréquence ou de phaseSynchronisation utilisant comme référence de fréquence les niveaux d'énergie de molécules, d'atomes ou de particules subatomiques
G04F 5/14 - Appareils pour la production d'intervalles de temps prédéterminés, utilisés comme étalons utilisant des horloges atomiques
4.
SINGLE-DOMAIN ANTIBODY FOR INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY
The present invention relates to a binding agent capable of specifically binding to and inhibiting competitively a neutrophil elastase, which binding agent comprises an immunoglobulin single variable domain (ISVD), as well as related products, methods, and uses, such as in particular methods and uses aimed at the prevention, treatment, or diagnostics of inflammatory diseases.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITÉ DE STRASBOURG (France)
UNIVERSITÉ DE LIÈGE (Belgique)
Inventeur(s)
Zanier, Katia
Donzeau, Mariel
Chariot, Alain
Shostak, Kateryna
Li, Changqing
Abrégé
The present invention concerns new peptides and polypeptides that bind to IKK and inhibit the NF-κB signaling pathway. The present invention also relates to a method of inhibiting the NF-κB signaling pathway and a method of identifying small molecules targeting IKK dimers. The present invention further provides pharmaceutical compositions and their use in a method for treating and/or preventing a disorder regulated by the NF-κB signaling pathway.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 38/00 - Préparations médicinales contenant des peptides
A gas sensor device (10) is configured to detect boar taint in a gas sample of volatised boar fat (5) by using a difference between i) a change in a first signal of a first sensor (2) over a sampling period and ii) a change in a second signal of a second sensor (2) over a sampling period to differentiate between a presence and an absence of boar taint. The gas sensor device (10) comprises a hemispherical enclosure (3) configured to be put in close contact with the surface of the boar fat (5) in order to sample VOCs being volatised from the boar fat (5). The VOCs are volatised by placing a heating device (1) in contact with the surface of the boar fat (5) and heating up to a temperature in the range from 200°C to 500°C. The gas sensor device (10) is designed to be used at line on the production line of a slaughterhouse.
Fundacio Institut De Bioenginyeria De Catalunya (Espagne)
Barcelona Institute For Global Health (Espagne)
Foundation For Research And Technology Hellas (Grèce)
Inventeur(s)
Grandfils, Christian
Sevrin, Chantal
Fernàndez Busquets, Xavier
Siden-Kiamos, Inga
Vontas, John
Abrégé
The invention provides a complex comprising at least one hydrophobic active agent, an ionic polymer comprising a repetitive unit of formula (I):
The invention provides a complex comprising at least one hydrophobic active agent, an ionic polymer comprising a repetitive unit of formula (I):
The invention provides a complex comprising at least one hydrophobic active agent, an ionic polymer comprising a repetitive unit of formula (I):
wherein R1 represents a hydrogen atom or a straight or branched chain alkyl group, preferably a straight or branched chain alkyl group comprising from 1 to 6 carbon atoms, for example a methyl group; R2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at a physiological pH wherein the ionic polymer is a homopolymer or a random copolymer, wherein the repetitive unit of formula (I) in a random copolymer comprises (dimethylamino)ethyl methacrylate, wherein the molar proportion of (dimethylamino)ethyl methacrylate repetitive units to the total number of repetitive units in a random copolymer is greater than 50%, and wherein the at least one hydrophobic active agent has a molecular weight of from 100 to 1500 g/mol; a complex for use in a method of medical treatment; a pharmaceutical composition; and a method of preparing a complex or pharmaceutical composition according to the invention which method comprises the steps of:
The invention provides a complex comprising at least one hydrophobic active agent, an ionic polymer comprising a repetitive unit of formula (I):
wherein R1 represents a hydrogen atom or a straight or branched chain alkyl group, preferably a straight or branched chain alkyl group comprising from 1 to 6 carbon atoms, for example a methyl group; R2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at a physiological pH wherein the ionic polymer is a homopolymer or a random copolymer, wherein the repetitive unit of formula (I) in a random copolymer comprises (dimethylamino)ethyl methacrylate, wherein the molar proportion of (dimethylamino)ethyl methacrylate repetitive units to the total number of repetitive units in a random copolymer is greater than 50%, and wherein the at least one hydrophobic active agent has a molecular weight of from 100 to 1500 g/mol; a complex for use in a method of medical treatment; a pharmaceutical composition; and a method of preparing a complex or pharmaceutical composition according to the invention which method comprises the steps of:
(a) dissolving the hydrophobic active agent and the ionic polymer in one or more non-aqueous solvents to form the complex wherein the one or more non-aqueous solvents are miscible with water; and
The invention provides a complex comprising at least one hydrophobic active agent, an ionic polymer comprising a repetitive unit of formula (I):
wherein R1 represents a hydrogen atom or a straight or branched chain alkyl group, preferably a straight or branched chain alkyl group comprising from 1 to 6 carbon atoms, for example a methyl group; R2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at a physiological pH wherein the ionic polymer is a homopolymer or a random copolymer, wherein the repetitive unit of formula (I) in a random copolymer comprises (dimethylamino)ethyl methacrylate, wherein the molar proportion of (dimethylamino)ethyl methacrylate repetitive units to the total number of repetitive units in a random copolymer is greater than 50%, and wherein the at least one hydrophobic active agent has a molecular weight of from 100 to 1500 g/mol; a complex for use in a method of medical treatment; a pharmaceutical composition; and a method of preparing a complex or pharmaceutical composition according to the invention which method comprises the steps of:
(a) dissolving the hydrophobic active agent and the ionic polymer in one or more non-aqueous solvents to form the complex wherein the one or more non-aqueous solvents are miscible with water; and
(b) progressively replacing the one or more non-aqueous solvents with water.
A61K 47/58 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. poly[méth]acrylate, polyacrylamide, polystyrène, polyvinylpyrrolidone, alcool polyvinylique ou résine d’acide sulfonique de polystyrène
A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
A61K 31/7064 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées
A61K 47/61 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique le composé organique macromoléculaire étant un polysaccharide ou l’un de ses dérivés
8.
POLYMER DERIVATIVES AND THEIR USE AS LIPID NANOPARTICLE MODIFIERS
The present invention relates to a polymer derivative comprising a hydrophilic segment obtained from the polymerisation of N-methyl-N- vinylacetamide (PNMVA), coupled to at least one hydrophobic segment, said hydrophobic segment comprising at least one aliphatic chain of 8 to 28 carbon atoms. The present invention also relates to a method for preparing such polymer derivative. Lipid nanoparticles modified by PNMVA-based derivatives were prepared and advantages were shown compared to PEgylated lipid nanoparticles. The present invention also relates to the medical use of lipid nanoparticles containing PNMVA-based derivatives, particularly to the use of nucleic acid delivery, for example SiRNA delivery to target tumor cells.
C08F 126/02 - Homopolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par une liaison simple ou double à l'azote ou par un hétérocycle contenant de l'azote par une simple ou une double liaison à l'azote
C08F 8/32 - Introduction d'atomes d'azote ou de groupes contenant de l'azote par réaction avec des amines
C08F 8/44 - Préparation de sels métalliques ou de sels d'ammonium
9.
MICROFLUIDIC DEVICE FOR MANIPULATING A DISCRETE ELEMENT
A microfluidic device for use in field of droplet microfluidics is disclosed. The microfluidic device can manipulate a discrete element, for example a droplet. The discrete element may include a medium and a component. The microfluidic device may include a main microfluidic channel, some stopping elements and an attractive mechanism that may retain, physically and in a releasable way, the component at a given location in the main microfluidic channel. The discrete element may be split into a first and second parts in such a way that the component ends in the second parts. The microfluidic device. may be used especially for a single-cell analysis.
CENTRE DE RECHERCHES DES INSTITUTS GROUPES DE LA HAUTE ECOLE LIBRE MOSANE (Belgique)
UNIVERSITE DE LIEGE (Belgique)
Inventeur(s)
Oprenyeszk, Frédéric
Pierre, Julien
Quinting, Birgit
Stordeur, Philippe
Nolens, Grégory
Nizet, Christophe
Abrégé
The present invention relates to a breast implant (1) and to a process to produce at least part of it by additive manufacturing. The breast implant (1) includes a first part (10), more rigid, along an axis (5), and a second part (20), more resorbable, around the first part (10). The implant (1) is bio- absorbable and elastically deformable in a direction perpendicular to the axis (5). The implant (1) is suitable for colonization by the vascular network with fat cells (differentiated cells) and their precursors (undifferentiated cells).
aa of at least 20 when measured in acetonitrile, wherein the reaction is carried out at a temperature of at least 90 °C and up to 150 °C, and wherein the first channel has an inner hydraulic diameter of from 100 to 2000 μm, and a pressure in the first channel is adapted to keep the solvent liquid.
C07C 68/04 - Préparation des esters de l'acide carbonique ou de l'acide formique halogéné à partir de l'anhydride carbonique ou de carbonates inorganiques
C07C 69/96 - Esters de l'acide carbonique ou de l'acide formique halogéné
Fluidic unit (2), preferably microfluidic, for trapping a discrete element (10) in a liquid sample (100a) and comprising: • a well (3) for receiving a volume of a liquid (100) comprising the discrete element (10); • a well output conduit (4); • a metering chamber (5) in fluid communication with the well (3) through said well output conduit (4), for metering a liquid sample (100a) of the volume of the liquid (100) received from the well (3); • an obstructable waste output conduit (6) for evacuating an excess portion (100b) of the volume of the liquid (100) from the metering chamber (5).
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
VRIJE UNIVERSITEIT BRUSSEL (Belgique)
KTH HOLDING AB (Suède)
Inventeur(s)
Caers, Jo
Duray, Elodie
Dumoulin, Mireille
D'Huyvetter, Matthias
Eriksson Karlström, Amelie
Abrégé
The present invention relates to medical imaging, disease monitoring and theranostic approaches in neoplastic diseases of certain anti-CD38 single-domain antibodies (sdAb).
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Business performance management software; Reporting software; Software for identifying, monitoring, managing, analyzing, compiling, visualizing and reporting data; Computer software platforms, recorded or downloadable; Downloadable computer software applications for mobile devices; Downloadable educational course materials. Business advisory services relating to company performance; Business organization advice; Advertising, marketing and promotional consultancy, advisory and assistance services; Business auditing; Statistical analysis and reporting services for business purposes; Compilation of statistical and mathematical data; Computerized auditing. Software as a service (SAAS) featuring business performance management software; Software as a service (SAAS) services featuring software for data collection, data management, data analysis, process and data automation, data reporting and data interpretation and collaboration; Quality audit; Computer programming services for commercial analysis and reporting; Development of databases.
15.
COMPOSITION FOR PROMOTING PLANTS GROWTH AND/OR FOR PROTECTING PLANTS AGAINST AT LEAST ONE PLANT PEST AND/OR ONE PLANT DISEASE
The present disclosure relates to a composition for promoting plants growth and/or for protecting plants against at least one plant pest and/or one plant disease, the composition comprising simultaneously at least one bacteria of the genus Bacillus producing antifungal lipopeptides, at least one fungi of the genus Trichoderma, and at least one nitrogen mineral source. The present disclosure also relates to the use of such a composition and to a method for obtaining such a composition. The present disclosure also relates to a co-culture medium for producing at least in part such a composition.
A01N 37/44 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant au moins un groupe carboxylique ou un thio-analogue, ou un de leurs dérivés, et un atome d'azote lié au même squelette carboné par une liaison simple ou double, cet atome d'azote ne faisant pas partie d'un dérivé ou d'un thio-analogue d'un groupe carboxylique, p. ex. acides aminocarboxyliques
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
Inventeur(s)
Lancellotti, Patrizio
Oury, Cécile
Jerome, Christine
Detrembleur, Christophe
Aqil, Abdelhafid
Melo, Sofia
Pierrard, Anna
Abrégé
A medical device comprising one or more polyhydroxyurethane (PHU) and a method of manufacturing thereof. Use of the medical device to load and release or graft bioactive molecules, particularly antimicrobial, anti-thrombotic and anticalcification molecules
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 29/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
The present invention relates to a curable isocyanate-free formulation for preparing a polyurethane self-blowing foam comprising at least one multifunctional cyclic carbonate having at least two cyclic carbonate groups at the end of the chain (compound A), at least one multifunctional amine (compound B), water or/and a water source and optionally at least one catalyst (compound D), to a process for preparing said foams and to the thus obtained foams, to a process for recycling the obtained foams and to the thus recycled foams.
C08J 9/02 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par la réaction des monomères ou par des agents de modification durant la préparation ou la modification des macromolécules
C08J 9/08 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par un agent de gonflage introduit au préalable par un agent chimique de gonflage dégageant de l'anhydride carbonique
The present invention relates to a compound of formula I, a stereoisomer, a tautomer and/or a dimer thereof or a salt thereof, (I) wherein M is a metal among the group of Mg, Cu and Zn; R1is a methyl group or a formyl group; R2 is a carboxylic acid or a methyl ester, for use in the prevention or treatment of a bacterial infection in a subject and to the uses of such compound as antibacterial agent or particularly as preserving agents, and to processes for obtaining a microalgal extract comprising such compounds.
A61K 31/409 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant quatre de ces cycles, p. ex. dérivés de la porphine, bilirubine, biliverdine
A61K 8/00 - Cosmétiques ou préparations similaires pour la toilette
A61K 36/00 - Préparations médicinales de constitution indéterminée contenant du matériel provenant d'algues, de lichens, de champignons, ou de plantes, ou leurs dérivés, p. ex. médicaments traditionnels à base de plantes
C07D 487/00 - Composés hétérocycliques contenant des atomes d'azote comme uniques hétéro-atomes dans le système condensé, non prévus par les groupes
C12N 1/00 - Micro-organismes, p. ex. protozoairesCompositions les contenantProcédés de culture ou de conservation de micro-organismes, ou de compositions les contenantProcédés de préparation ou d'isolement d'une composition contenant un micro-organismeLeurs milieux de culture
C07D 487/22 - Composés hétérocycliques contenant des atomes d'azote comme uniques hétéro-atomes dans le système condensé, non prévus par les groupes dans lesquels le système condensé contient au moins quatre hétérocycles
C12P 17/10 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'azote comme unique hétéro-atome du cycle
Sphingobiumxenophagumxenophagum as a biological control agent for controlling a pest population, more specifically for treating or preventing a disease in a plant or seed in need thereof.
A01N 25/02 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles contenant des liquides comme supports, diluants ou solvants
The present invention relates to a curable isocyanate-free formulation for preparing a polyurethane self-blowing foam comprising at least one multifunctional cyclic carbonate having at least two cyclic carbonate groups at the end of the chain (compound A), at least one multifunctional amine (compound B), at least one masked thiol precursor (compound C) and optionally at least one catalyst (compound D), to a process for preparing said foams, to the thus obtained foams and to the recycling of said foams.
C08J 9/02 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par la réaction des monomères ou par des agents de modification durant la préparation ou la modification des macromolécules
The present invention relates to a compound of formula (I), a tautomer, an enantiomer or a diastereomer thereof, wherein R1, R2, R3 and X have the same meaning as that defined in the claims and the description. The present invention also relates to uses of such compounds as inhibitors of bacterial adhesion and biofilm formation on a surface, methods ex-vivo for preventing bacterial growth in biofilm formation and the use of such compounds in diagnosing or prognosing bacterial infections.
A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p. ex. adénosine, acide adénylique
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Pirotte, Bernard
Francotte, Pierre
El Amri, Chahrazade
Reboud-Ravaux, Michèle
Chaaya, Nancy
Lesenfants, Cindy
Abrégé
Compound of Formula (I) wherein R1is a substituted linear or branched alkyl chain of 1 to 6 carbon atoms; R2is a basic group bearing a positive charge at physiological pH or a precursor thereof, such basic group or precursor thereof being optionally preceded by a linear or branched alkyl chain of 1 to 6 carbon atoms and R2being in the ortho, meta or para position of the ester group on the aryl ring; R3is a halogen with x being an integer between 0 and 4; R4is a halogen with y being an integer between 0 and 3; or a prodrug thereof, and/or a salt thereof, for its use in the treatment of respiratory diseases and compounds of formula I wherein R2 is a basic group bearing a positive charge at physiological pH or a precursor thereof, such basic group or precursor thereof being preceded by a linear or branched alkyl chain of 1 to 6 carbon atoms, preferably of 1 to 2 carbon atoms for use as a medicament.
The invention provides a complex comprising at least one proteinaceous agent, an ionic polymer comprising a repetitive unit of formula (I):
The invention provides a complex comprising at least one proteinaceous agent, an ionic polymer comprising a repetitive unit of formula (I):
The invention provides a complex comprising at least one proteinaceous agent, an ionic polymer comprising a repetitive unit of formula (I):
wherein R1 represents a hydrogen atom or a straight or branched chain alkyl group, preferably a straight or branched chain alkyl group comprising from 1 to 6 carbon atoms, for example a methyl group; R2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at a physiological pH; and optionally a surfactant; a complex for use in a method of medical treatment; a pharmaceutical composition
A61K 47/58 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. poly[méth]acrylate, polyacrylamide, polystyrène, polyvinylpyrrolidone, alcool polyvinylique ou résine d’acide sulfonique de polystyrène
Module for measuring groundwater flux and optionally solute flux comprising a fluid circuit loop having an abstraction connection and a discharge connection for connecting with a groundwater well respectively at two ends of a column of fluid in said groundwater well; an input line for receiving a volume of tracer, said input line being fluidly connected to the fluid circuit loop upstream from the discharge connection, and comprising an injection pump for injecting said volume of tracer through the discharge connection in the groundwater well; an output line for extracting a volume of fluid, said output line being fluidly connected to the fluid circuit loop downstream from the abstraction connection; a first measuring unit for measuring a tracer concentration in the fluid, said measuring unit being fluidly connectable to the fluid circuit loop between the abstraction connection and the discharge connection. System comprising such module and method for measuring groundwater flux with such module.
G01V 9/02 - Détermination de l'existence ou du cours d'une eau souterraine
G01F 1/704 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu utilisant des zones marquées ou non homogènes de l’écoulement de fluide, p. ex. des variations statistiques d'un paramètre du fluide
G01P 5/00 - Mesure de la vitesse des fluides, p. ex. d'un courant atmosphériqueMesure de la vitesse de corps, p. ex. navires, aéronefs, par rapport à des fluides
G01F 1/7086 - Mesure du temps de parcours d'une distance déterminée utilisant des dispositions de détection optique
A container system for receiving a liquid sample has a receptacle including a substantially tubular portion for receiving a predetermined volume of the sample. The substantially tubular portion has a first open end and an at least partially openable second end; and a chamber at least partially surrounding the substantially tubular portion. The chamber has an at least partially open upper portion and a closed bottom.
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
VRIJE UNIVERSITEIT BRUSSEL (Belgique)
KTH HOLDING AB (Suède)
Inventeur(s)
Caers, Jo
Duray, Elodie
Dumoulin, Mireille
D'Huyvetter, Matthias
Eriksson Karlström, Amelie
Abrégé
The present invention relates to medical imaging, disease monitoring and theranostic approaches in neoplastic diseases of certain anti-CD38 single-domain antibodies (sdAb).
A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
The present invention relates to a curable isocyanate-free formulation for preparing a polyurethane self-blowing foam comprising at least one multifunctional cyclic carbonate having at least two cyclic carbonate groups at the end of the chain (compound A), at least one multifunctional amine (compound B), water or/and a water source and optionally at least one catalyst (compound D), to a process for preparing said foams and to the thus obtained foams, to a process for recycling the obtained foams and to the thus recycled foams.
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemistry apparatus and instruments; Chemical reactors; Tubular reactors; Apparatus and instruments for controlling and/or monitoring reactors and/or sensors and/or other equipment of chemistry; Software, in particular for use in the field of chemistry; software for chemical synthesis, production, reaction, purification and/or transformation; Application software for use in the field of chemistry; Collaborative software for use in the field of chemistry; Platform software for use in the field of chemistry. Development and test of chemical methods, including production method, purification methods, transformation methods; Chemical engineering; Scientific laboratory services in the field of chemistry; Hosting services, software as a service, and rental of software; Software as a service [SaaS]; Development of computer platforms; Platform as a Service [PaaS]; Chemical laboratories.
29.
DEPLETION OF EXT1 EXPRESSION AND/OR ACTIVITY IMPROVES CELLULAR PRODUCTION OF BIOLOGICAL ENTITIES
The use of an inhibitor of EXT1 expression and/or activity for the production of a biological entity in a cell. Also, the use of a cell having at least depleted EXT1 expression and/or activity for the production of a biological entity. Further, evidence is provided about the role of glycosylation in rapid dynamism of ER shaping and function. In particular, depletion of EXT1 results in a recomposed ER shaping, which could benefit production of recombinant proteins.
The invention relates to a process for preparing core-shell particles comprising the steps of (i) providing a dispersion of primary magnetic particles having a mean diameter lower than 200 nm in a solvent; (ii) adding one or more (semi-)metal (oxyhydr)oxide(s) and/or one or more precursor(s) of a (semi-)metal (oxyhydr)oxide to said dispersion; (iii) optionally adding a hydrolysis agent for said one or more precursor(s); (iv) injecting the dispersion in a spray dryer; whereby a (semi-)metal (oxyhydr)oxide shell is formed on the magnetic particles during spray drying. The invention also relates to particles obtainable by said process, to a formulation of said particles in a solvent and to the use of said particles or said formulation for RNA or DNA extraction.
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
31.
METHODS AND TOOLS FOR ANALYSING THE DUCHENNE MUSCULAR DYSTROPHY (DMD) GENE
Centre Hospitalier Universitaire de Liège (Belgique)
Université de Liège (Belgique)
Inventeur(s)
Beckers, Pablo
Boemer, François
Servais, Laurent
Bours, Vincent
Abrégé
An aspect of the invention provides a method for analysing the Duchenne Muscular Dystrophy (DMD) gene in a sample containing genetic material of a subject, wherein the method detects the presence or absence of at least exons 7, 43, 44, 45, 46, 49, 50, 51, 52 and 54 of the DMD gene in the genetic material of the subject, wherein the detection of the presence or absence of the exons comprises multiplex polymerase-based nucleic acid amplification. Another aspect of the invention provides a method for analysing the DMD gene in a sample containing genetic material of a subject, wherein the method detects the presence or absence of at least exons 7, 43, 44, 45, 46, 49, 50, 51, 52 and 54 of the DMD gene in the genetic material of the subject, and wherein the sample is blood. Additional aspects of the invention provide tools applicable in the disclosed methods, such as primers, primer pairs, primer pair sets, oligonucleotide probes and probe sets, as well as compositions and kits containing the same.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
32.
METHOD FOR PRODUCING A MAGNETRON CAVITY FOR ATOMIC CLOCKS
The invention relates to a computer-assisted method for sizing and then producing a magnetron cavity for an atomic clock, in particular for a hydrogen maser, the cavity being substantially cylindrical and including at least two curved electrodes arranged along an arc of a circle and delimiting a substantially cylindrical space of predetermined radius r, the cavity also including a substantially cylindrical storage bulb of radius rs arranged in said space so that there is a radial gap ei between the at least two electrodes and the storage bulb.
G04F 5/14 - Appareils pour la production d'intervalles de temps prédéterminés, utilisés comme étalons utilisant des horloges atomiques
H01S 1/06 - Masers, c.-à-d. dispositifs utilisant l’émission stimulée de rayonnement électromagnétique dans la gamme des micro-ondes gazeux
H03L 7/26 - Commande automatique de fréquence ou de phaseSynchronisation utilisant comme référence de fréquence les niveaux d'énergie de molécules, d'atomes ou de particules subatomiques
33.
ACCESSORY FOR A PLATE OF A MICROFLUIDIC EXPERIMENTATION DEVICE, AND MICROFLUIDIC EXPERIMENTATION DEVICE
The invention relates to an accessory for a plate of a microfluidic experimentation device, comprising a first part and at least one second part, said second part being detachable from said first part, said first part having a plurality of through-holes arranged to enable fluid connection tubes to pass through said first part, said second part having: - at least one recess for at least one microfluidic chip, said recess being made in the thickness of said second part and having a light-passage hole, - a plurality of holes, each hole being arranged to accommodate a fluid reservoir.
The invention relates to a cassette intended to contain a microfluidic chip formed from a base made of rigid material and provided with a first wall and from a cover made of rigid material and provided with a second wall, said cassette having an analysis position and an introduction position. The first wall and the second wall each comprise an optically transparent viewing zone, said cassette comprising a series of connecting orifices, each orifice of the series of connecting orifices being designed to be passed through by a connecting tube allowing the passage of a fluid, the second wall also comprising at least one sample introduction orifice.
B01L 9/00 - Dispositifs de supportDispositifs de serrage
35.
CELL-FREE TRNA FRAGMENT-BASED TR-FRET SCREENING AND COMPETITION ASSAY FOR INHIBITORS OF HUMAN TRNA MODIFICATION ENZYMES USEFUL IN THE PREVENTION OR TREATMENT OF TRNA MODIFICATION RELATED CONDITIONS
A Cell-free tRNA fragment-based FRET screening and competition assay for inhibitors of human tRNA modification enzymes useful in the prevention or treatment of tRNA modification-related conditions is provided.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
36.
Pooled Crispr Inverse PCR Sequencing (PCIP-Seq): Simultaneous Sequencing of Viral Insertion Points and the Integrated Viral Genomes with Long Reads
The present invention relates to a method for detecting an integration pattern of a virus in a host genome. In particular, a method is provided encompassing selective cleavage of circularized DNA fragments carrying viral DNA with an RNA-guided endonuclease and at least one guide RNA or at least one pool of guide RNAs, followed by inverse PCR, in particular inverse long-range PCR, and sequencing. The invention further relates to kits for performing the method and application of the method.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
37.
MICROFLUIDIC DEVICE FOR MANIPULATING A DISCRETE ELEMENT
The present invention relates to the field of droplet microfluidics. It concerns a microfluidic device (1) for manipulating a discrete element (2), for example a droplet. The discrete element (2) comprises a medium (3) and a component (4). The microfluidic device (1) comprises a main microfluidic channel (11), some stopping elements (21, 22, 23) and an attractive mechanism (30) configured to retain, physically and in a releasable way, the component (4) at a given location in the main microfluidic channel (11). The discrete element (2) may be split into a first and second parts in such a way that the component (4) ends in the second parts. The microfluidic device (1) may be used especially for a single- cell analysis.
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA (Espagne)
BARCELONA INSTITUTE FOR GLOBAL HEALTH (Espagne)
FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (Grèce)
Inventeur(s)
Grandfils, Christian
Sevrin, Chantal
Fernàndez Busquets, Xavier
Siden-Kiamos, Inga
Vontas, John
Abrégé
The invention provides a complex comprising at least one hydrophobic active agent, an ionic polymer comprising a repetitive unit of formula (I): 5 I wherein R1 represents a hydrogen atom or a straight or branched chain alkyl group, preferably a straight or branched chain alkyl group comprising from 1 to 6 carbon atoms, for example a methyl group; R2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at a physiological pH wherein the ionic polymer is a homopolymer or a random copolymer, wherein the repetitive unit of formula (I) in a random copolymer comprises (dimethylamino)ethyl 10 methacrylate, wherein the molar proportion of (dimethylamino)ethyl methacrylate repetitive units to the total number of repetitive units in a random copolymer is greater than 50%, and wherein the at least one hydrophobic active agent has a molecular weight of from 100 to 1500 g/mol; a complex for use in a method of medical treatment; a pharmaceutical composition; and a method of preparing a complex or pharmaceutical composition according to the invention which method comprises the steps of: 15 (a) dissolving the hydrophobic active agent and the ionic polymer in one or more non‐aqueous solvents to form the complex wherein the one or more non‐aqueous solvents are miscible with water; and (b) progressively replacing the one or more non‐aqueous solvents with water.
A61K 47/58 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. poly[méth]acrylate, polyacrylamide, polystyrène, polyvinylpyrrolidone, alcool polyvinylique ou résine d’acide sulfonique de polystyrène
A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
VRIJE UNIVERSITEIT BRUSSEL (Belgique)
KTH HOLDING AB (Suède)
Inventeur(s)
Caers, Jo
Duray, Elodie
Dumoulin, Mireille
D’huyvetter, Matthias
Eriksson Karlström, Amelie
Abrégé
The present invention relates to medical imaging, disease monitoring and theranostic approaches in neoplastic diseases of certain anti-CD38 single-domain antibodies (sdAb).
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
40.
EXTRACELLULAR VESICLES CONTAINING MIR-142-3P TO TREAT FIBROSING DISEASES
Centre Hospitalier Universitaire de Liège (Belgique)
Inventeur(s)
Guiot, Julien
Struman, Ingrid
Njock, Makon-Sébastien
Abrégé
The present invention relates to pharmaceutical formulations comprising extracellular vesicles wherein the content of the vesicles comprises microRNA miR-142-3p, methods for producing the pharmaceutical formulations, and uses of the formulations to treat fibro-inflammatory diseases in a subject.
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
A61K 35/15 - Cellules de la lignée des myéloïdes, p. ex. granulocytes, basophiles, éosinophiles, neutrophiles, leucocytes, monocytes, macrophages ou mastocytesCellules précurseurs myéloïdesCellules présentatrices d’antigène, p. ex. cellules dendritiques
The inventors have found that a an assay using stably transformed human cell lines comprising repetitions of codons sensitive to tRNA modifications upstream of a first luminescence-based reporter gene and repetitions of their synonymous codons upstream of a second luminescence-based reporter gene may be helpful in rapidly identifying modulators of tRNA modifying enzymes.
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
42.
COMPOSITION FOR PROMOTING PLANTS GROWTH AND/OR FOR PROTECTING PLANTS AGAINST AT LEAST ONE PLANT PEST AND/OR ONE PLANT DISEASE
The present invention relates to a composition for promoting plants growth and/or for protecting plants against at least one plant pest and/or one plant disease, said composition comprising simultaneously at least one bacteria of the genus Bacillus producing antifungal lipopeptides, at least one fungi of the genus Trichoderma, and at least one nitrogen mineral source. The present invention also relates to the use of such a composition and to a method for obtaining such a composition. The present invention also relates to a co-culture medium for producing at least in part such a composition.
The present invention relates to methods for determining the concentration of a carbapenem antibiotic in a biological sample. In particular, the present invention relates to methods for determining the concentration of a carbapenem antibiotic in a biological sample, comprising the steps of: (a) providing a blaOXA-48 class D beta-lactamase (blaOXA-48) or a functionally active variant or fragment thereof; (b) providing a biological sample; (c) contacting the blaOXA-48 or functionally active variant or fragment thereof with the biological sample; and (d) determining the concentration of the carbapenem antibiotic in the biological sample.
G01N 33/94 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des narcotiques
44.
NEW ANTIMICROBIAL AND ANTITHROMBOGENIC MEDICAL DEVICE
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
Inventeur(s)
Lancellotti, Patrizio
Oury, Cécile
Jerome, Christine
Detrembleur, Christophe
Aqil, Abdelhafid
Melo, Sofia
Pierrard, Anna
Abrégé
A medical device comprising one or more polyhydroxyurethane (PHU) and a method of manufacturing thereof.Use of the medical device to load and release or graft bioactive molecules, particularly antimicrobial,anti-thrombotic and anticalcification molecules
The present invention relates to a curable isocyanate-free formulation for preparing a polyurethane self-blowing foam comprising at least one multifunctional cyclic carbonate having at least two cyclic carbonate groups at the end of the chain (compound A), at least one multifunctional amine (compound B), at least one multifunctional thiol (compound C) and at least one catalyst (compound D), to a process for preparing said foams, to the thus obtained foams and the recycling of said foams.
C08J 9/08 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par un agent de gonflage introduit au préalable par un agent chimique de gonflage dégageant de l'anhydride carbonique
The present invention relates to a curable isocyanate-free formulation for preparing a polyurethane self-blowing foam comprising at least one multifunctional cyclic carbonate having at least two cyclic carbonate groups at the end of the chain (compound A), at least one multifunctional amine (compound B), at least one masked thiol precursor (compound C) and optionally at least one catalyst (compound D), to a process for preparing said foams, to the thus obtained foams and to the recycling of said foams.
C08J 9/02 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par la réaction des monomères ou par des agents de modification durant la préparation ou la modification des macromolécules
C08J 11/06 - Récupération ou traitement des résidus des polymères sans réaction chimique
47.
OSTEOMODULIN AND OSTEOMODULIN FRAGMENTS AS BIOMARKERS FOR OSTEOARTHRITIS AND USE THEREOF
The present invention refers to osteomodulin (OMD) protein or fragment of osteomodulin (OMD) protein for use in the prognosis and/or diagnosis of osteoarthritis and/or subchondral bone sclerosis of mammals, preferably human individuals. The present invention further refers to a method for prognosis and/or diagnosis of osteoarthritis and/or subchondral bone sclerosis, comprising the following steps: i) measuring osteomodulin (OMD) protein or a fragment or fragments of osteomodulin (OMD) protein in samples of body fluids of mammalian individuals, preferably human serum samples; ii) judging that decreased levels of osteomodulin (OMD) protein or of said fragment(s) compared to levels in body fluids, preferably serum, of healthy individuals indicate onset of osteoarthritis and/or subchondral bone sclerosis. The present invention also provides an immunological binding partner specifically binding to osteomodulin (OMD) protein or fragment of osteomodulin (OMD) protein for use in the prognosis and/or diagnosis of osteoarthritis and/or subchondral bone sclerosis of mammals, preferably human individuals and a kit comprising said immunological binding partner.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
48.
SYMBIOTIC COMPOSITION AS FEED ADDITIVE FOR PIGLETS OR SOWS AND THE USE THEREOF
Disclosed is a symbiotic composition for the treatment or prevention of dysbiosis in piglets during nursing and/or post-weaning, comprising, an effective therapeutic or preventative quantity of (i) Enterococcus faecium, or (ii) Bifidobacterium animalis lactis, or (iii) Clostridium butyricum, or (iv) Bifidobacterium crudilactis, as probiotic and one or more prebiotics, this composition being intended for administration to a pregnant or nursing sow and/or to a nursing and/or post-weaning piglet, in order to promote an anti-inflammatory environment in the intestine of the nursing and/or post-weaning piglet.
A23K 10/18 - Ajout de micro-organismes ou de leurs produits d’extraction, p. ex. de protéines provenant d’organismes unicellulaires, à des compositions de produits alimentaires de micro-organismes vivants
LE CENTRE WALLON DE RECHERCHES AGRONOMIQUES (Belgique)
UNIVERSITÉ DE LIÈGE (Belgique)
VESALE PHARMACEUTICA (Belgique)
Inventeur(s)
Arevalo Sureda, Ester
Delcenserie, Véronique
Everaert, Nadia
Liénart Van Lidth De Jeude, Jehan
Martinez, Elisa
Sabri, Ahmed
Thonart, Philippe
Abrégé
Disclosed is a symbiotic composition for the treatment or prevention of dysbiosis in piglets during nursing and/or post-weaning, comprising, an effective therapeutic or preventative quantity of (i) Enterococcus faecium, or (ii) Bifidobacterium animalis lactis, or (iii) Clostridium butyricum, or (iv) Bifidobacterium crudilactis, as probiotic and one or more prebiotics, this composition being intended for administration to a pregnant or nursing sow and/or to a nursing and/or post-weaning piglet, in order to promote an anti-inflammatory environment in the intestine of the nursing and/or post-weaning piglet.
A23K 10/18 - Ajout de micro-organismes ou de leurs produits d’extraction, p. ex. de protéines provenant d’organismes unicellulaires, à des compositions de produits alimentaires de micro-organismes vivants
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
Inventeur(s)
Oury, Cécile
Lancellotti, Patrizio
Nchimi, Alain
Luxen, André
Goffin, Eric
Stouse, Adrien
Abrégé
A method of imaging a bacterial infection in a host mammal using Triazolo[4,5-d]pyrimidine derivatives of formula (I):
A method of imaging a bacterial infection in a host mammal using Triazolo[4,5-d]pyrimidine derivatives of formula (I):
A method of imaging a bacterial infection in a host mammal using Triazolo[4,5-d]pyrimidine derivatives of formula (I):
Also disclosed are compositions including the triazolo[4,5-d]pyrimidine derivative.
The present invention relates to a method and a composition for eliciting at least one defense mechanism in plants against plant pests and plant diseases.
A01N 37/42 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant dans le même squelette carboné un groupe carboxylique ou un thio-analogue, ou un de leurs dérivés, et un atome de carbone ne comportant que deux liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. acides cétocarboxyliques
A01P 21/00 - Régulateurs de croissance des végétaux
The invention provides a complex comprising at least one proteinaceous agent, an ionic polymer comprising a repetitive unit of formula (I): wherein R1represents a hydrogen atom or a straight or branched chain alkyl group, preferably a straight or branched chain alkyl group comprising from 1 to 6 carbon atoms, for example a methyl group; R2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at a physiological pH; and optionally a surfactant; a complex for use in a method of medical treatment; a pharmaceutical composition
A61K 47/58 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. poly[méth]acrylate, polyacrylamide, polystyrène, polyvinylpyrrolidone, alcool polyvinylique ou résine d’acide sulfonique de polystyrène
53.
Agonists of Human Kisspeptin Receptor for Modulating Sexual Desire
The present application relates to an agonist of a human kisspeptin receptor for use in a method of treating a disorder of sexual desire in human females, a method of treating a disorder of sexual desire in a human female patient, comprising administering to said patient a therapeutically effective amount of an agonist of a human kisspeptin receptor and a non-therapeutic method of enhancing libido or inducing sexual arousal in a human female subject, comprising administering to said subject an amount of an agonist of a human kisspeptin receptor sufficient to enhance libido in said subject.
A61P 15/00 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/568 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p. ex. androstane, testostérone
A61K 31/5685 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p. ex. androstane, testostérone ayant un groupe oxo en position 17, p. ex. androstérone
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
Disclosed is a container system for receiving a liquid sample, the system comprising a receptacle including a substantially tubular portion for receiving a predetermined volume of the sample, the substantially tubular portion having a first open end and an at least partially openable second end; and a chamber at least partially surrounding the substantially tubular portion, the chamber having an at least partially open upper portion and a closed bottom.
In a first aspect, the present invention relates to a composite anode material, comprising: (i) a layer of silicon-carbon (Si/C) composite material comprising silicon-carbon composite particles, and (ii) a graphene oxide (GO) layer covering the layer of silicon-carbon composite material; wherein the silicon-carbon composite particles each comprise a plurality of silicon (Si) particles intermixed with a carbon-based material, and wherein the silicon-carbon composite particles comprise a porous shell surrounding a hollow, the porous shell comprising the plurality of silicon particles intermixed with the carbon-based material.
H01M 4/36 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
H01M 10/36 - Accumulateurs non prévus dans les groupes
H01M 4/134 - Électrodes à base de métaux, de Si ou d'alliages
H01M 4/133 - Électrodes à base de matériau carboné, p. ex. composés d'intercalation du graphite ou CFx
H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
An inhalable cyclodextrin for use in the treatment and prevention of late phase bronchoconstriction in allergen-induced asthma is disclosed. Further disclosed is the use of a cyclodextrin in the treatment and prevention by inhalation of late phase bronchoconstriction in allergen-induced asthma.
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
VRIJE UNIVERSITEIT BRUSSEL (Belgique)
Inventeur(s)
Caers, Jo
Duray, Elodie
Dumoulin, Mireille
D’huyvetter, Matthias
Abrégé
The present invention relates to medical imaging, disease monitoring and theranostic approaches in neoplastic diseases of certain anti-CD38 single-domain antibodies (sdAb).
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
The invention relates to a process for preparing core-shell particles comprising the steps of (i) providing a dispersion of primary magnetic particles having a mean diameter lower than 200 nm in a solvent; (ii) adding one or more (semi-)metal (oxyhydr)oxide(s) and/or one or more precursor(s) of a (semi-)metal (oxyhydr)oxide to said dispersion; (iii) optionally adding a hydrolysis agent for said one or more precursor(s); (iv) injecting the dispersion in a spray dryer; whereby a (semi-)metal (oxyhydr)oxide shell is formed on the magnetic particles during spray drying. The invention also relates to particles obtainable by said process, to a formulation of said particles in a solvent and to the use of said particles or said formulation for RNA or DNA extraction.
B01J 2/06 - Procédés ou dispositifs pour la granulation de substances, en généralTraitement de matériaux particulaires leur permettant de s'écouler librement, en général, p. ex. en les rendant hydrophobes par division du produit liquide en gouttelettes, p. ex. par pulvérisation, et solidification des gouttelettes en milieu liquide
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
B01J 20/08 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe contenant de l'oxyde ou de l'hydroxyde d'aluminiumCompositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe contenant de la bauxite
59.
METHODS AND TOOLS FOR ANALYSING THE DUCHENNE MUSCULAR DYSTROPHY (DMD) GENE
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
UNIVERSITÉ DE LIÈGE (Belgique)
Inventeur(s)
Beckers, Pablo
Boemer, François
Servais, Laurent
Bours, Vincent
Abrégé
DMDDMDDMD gene in a sample containing genetic material of a subject, wherein the method detects the presence or absence of at least exons 7, 43, 44, 45, 46, 49, 50, 51, 52 and 54 of the DMD gene in the genetic material of the subject, and wherein the sample is blood. Additional aspects of the invention provide tools applicable in the disclosed methods, such as primers, primer pairs, primer pair sets, oligonucleotide probes and probe sets, as well as compositions and kits containing the same.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
60.
PYRIMIDINE DERIVATIVES FOR PREVENTION AND TREATMENT OF GRAM-NEGATIVE BACTERIAL INFECTION, CONTAMINATION AND FOULING
New pyrimidine derivatives together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-negative bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-negative biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives together with a membrane penetrating agent; for use as radiotracer in diagnosing or prognosing Gram-negative bacterial infection in a host mammal.
A01N 43/90 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant plusieurs hétérocycles déterminants condensés entre eux ou avec un système carbocyclique commun
A01N 43/713 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec au moins quatre atomes d'azote comme uniques hétéro-atomes du cycle
61.
DEPLETION OF EXT1 EXPRESSION AND/OR ACTIVITY IMPROVES CELLULAR PRODUCTION OF BIOLOGICAL ENTITIES
The present invention relates to the use of an inhibitor of EXT1 expression and/or activity for the production of a biological entity in a cell. The invention also relates to the use of a cell having at least depleted EXT1 expression and/or activity for the production of a biological entity. The inventors provide herein evidences about the role of glycosylation in rapid dynamism of ER shaping and function. In particular, depletion of EXT1 results in a recomposed ER shaping, which could benefit production of recombinant proteins.
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
Inventeur(s)
Nikkels, Arjen
Abrégé
Fat tissue removal device comprising a cannula (100) comprising an evacuation tube (150) for connecting an evacuation system, a blunt cap (110) provided at a distal end of the cannula (100), and a rotatable shaft (130) comprising a cutting element (120) attached to the rotatable shaft, said rotatable shaft further being configured to be connectable to a driving device, the blunt cap (110) comprising a grinding chamber (160) for grinding fat tissue with the cutting element (120), an assembly comprising such device, a kit of parts for the removal of fat tissue, and a method for the removal of fat tissue with such device.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
The present invention relates to the use of an inhibitor of EXT1 expression and/or activity for the production of a biological entity in a cell. The invention also relates to the use of a cell having at least depleted EXT1 expression and/or activity for the production of a biological entity. The inventors provide herein evidences about the role of glycosylation in rapid dynamism of ER shaping and function. In particular, depletion of EXT1 results in a recomposed ER shaping, which could benefit production of recombinant proteins.
The present invention relates to a herbicidal composition comprising at least one essential oil as an active compound, at least one surfactant and at least one oily substance, said composition being under the form of an emulsion.
A01N 25/30 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles caractérisés par les agents tensio-actifs
A01N 65/44 - Poaceae ou Gramineae [famille des céréales], p. ex. bambou, citronnelle ou verveine des Indes
A01N 65/24 - Lauraceae [famille du laurier], p. ex. laurier, avocat, sassafras, cannelle ou camphre
65.
Microfluidic module for co-encapsulation in droplets
A microfluidic module for co-encapsulation in droplets of two populations of particles may include first and second modules for sorting the two populations. The modules may have their first outlets including first obstructive valves configured to at least partially obstruct the first outlets. The first outlets may be fluidly connected to a fusion module, including a fusion module means for merging at least one droplet from the first droplet population and at least one droplet from the second droplet population into a merged droplet comprising the two population of particles, and a control unit for controlling the first obstructive valves from information originating from a first and second module detection portion located upstream of the first outlets.
B01F 33/301 - Micromixeurs utilisant des moyens spécifiques pour disposer les écoulements à mélanger, p. ex. des géométries ou des dispositions de canaux
B01F 33/302 - Micromixeurs les matières à mélanger s'écoulant sous forme de gouttelettes
B01F 35/214 - Mesure caractérisée par les moyens pour mesurer
B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression
The present invention relates to a method for detecting an integration pattern of a virus, such as human papilloma virus (HPV) in a host genome. In particular, a method is provided encompassing selective cleavage of circularized DNA fragments carrying viral DNA with an RNA-guided endonuclease and at least one guide RNA or at least one pool of guide RNAs, followed by inverse PCR, in particular inverse long-range PCR, and sequencing ("Pooled CRISPR Inverse PCR sequencing (PCIP-seq)". The invention further relates to kits for performing the method and application of the method.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
67.
Pyrimidine derivatives for prevention and treatment of bacterial infections
Pyrimidine derivatives of formula (I):
optionally with a detectable isotope, pharmaceutical composition and method of preparation thereof. Pyrimidine derivatives for use in treatment or prevention of bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. Pyrimidine derivatives for use as radiotracer in diagnosing or prognosing bacterial infection in a host mammal.
C07D 473/40 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'halogènes ou des radicaux perhalogénoalkyles liés directement en position 2 ou 6
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The present invention relates to methods for determining the concentration of a carbapenem antibiotic in a biological sample. In particular, the present invention relates to methods for determining the concentration of a carbapenem antibiotic in a biological sample, comprising the steps of: (a) providing a blaOXA-48 class D beta-lactamase (blaOXA-48) or a functionally active variant or fragment thereof; (b) providing a biological sample; (c) contacting the blaOXA-48 or functionally active variant or fragment thereof with the biological sample; and (d) determining the concentration of the carbapenem antibiotic in the biological sample.
C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
C12N 9/78 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5)
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
G01N 33/94 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des narcotiques
69.
METHODS FOR DETERMINING THE CONCENTRATION OF A CARBAPENEM ANTIBIOTIC IN A BIOLOGICAL SAMPLE
The present invention relates to methods for determining the concentration of a carbapenem antibiotic in a biological sample. In particular, the present invention relates to methods for determining the concentration of a carbapenem antibiotic in a biological sample, comprising the steps of: (a) providing a blaOXA-48 class D beta-lactamase (blaOXA-48) or a functionally active variant or fragment thereof; (b) providing a biological sample; (c) contacting the blaOXA-48 or functionally active variant or fragment thereof with the biological sample; and (d) determining the concentration of the carbapenem antibiotic in the biological sample.
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
G01N 33/94 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des narcotiques
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE (Belgique)
Inventeur(s)
Oury, Cecile
Lancellotti, Patrizio
Nchimi, Alain
Luxen, Andre
Goffin, Eric
Abrégé
Triazolo[4,5-d]pyrimidine derivatives of formula (I) for use in prognosis and/or diagnosis of bacterial infection in a host mammal and method of imaging thereof. Formula (I) wherein R1 is C3-5 alkyl optionally substituted by one or more halogen atoms; R2 is a phenyl group, optionally substituted by one or more halogen atoms; R3 and R4 are each hydroxyl; R is XOH, wherein X is CH2, OCH2CH2, or a bond; or a pharmaceutical acceptable salt or solvate thereof, or a solvate of such a salt provided that when X is CH2 or a bond, R1 is not propyl; when X is CH2 and R1 CH2CH2CF3, butyl or pentyl, the phenyl group at R2 must be substituted by fluorine; when X is OCH2CH2 and R1 is propyl, the phenyl group at R2 must be substituted by fluorine.
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
Inventeur(s)
Oury, Cécile
Lancellotti, Patrizio
Nchimi, Alain
Luxen, André
Goffin, Eric
Abrégé
Triazolo[4,5-d]pyrimidine derivatives of formula (I) for use in prognosis and/or diagnosis of bacterial infection in a host mammal and method of imaging thereof. Formula (I) wherein R13-53-5 alkyl optionally substituted by one or more halogen atoms; R2is a phenyl group, optionally substituted by one or more halogen atoms; R3and R422222 or a bond, R122 and R12233, butyl or pentyl, the phenyl group at R2222 and R1 is propyl, the phenyl group at R2 must be substituted by fluorine.
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE (Belgique)
Inventeur(s)
Guiot, Julien
Struman, Ingrid
Njock, Makon-Sebastien
Abrégé
The present invention relates to pharmaceutical formulations comprising extracellular vesicles wherein the content of the vesicles comprises microRNA miR-142-3p, methods for producing the pharmaceutical formulations, and uses of the formulations to treat fibro-inflammatory diseases in a subject.
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
73.
EXTRACELLULAR VESICLES CONTAINING MIR-142-3P TO TREAT FIBROSING DISEASES
CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE (Belgique)
Inventeur(s)
Guiot, Julien
Struman, Ingrid
Njock, Makon-Sébastien
Abrégé
The present invention relates to pharmaceutical formulations comprising extracellular vesicles wherein the content of the vesicles comprises microRNA miR-142-3p, methods for producing the pharmaceutical formulations, and uses of the formulations to treat fibro-inflammatory diseases in a subject.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
The present invention relates to a curable isocyanate-free formulation for preparing a polyurethane self-blowing foam comprising at least one multifunctional cyclic carbonate having at least two cyclic carbonate groups at the end of the chain (compound A), at least one multifunctional amine (compound B), at least one multifunctional thiol (compound C) and at least one catalyst (compound D), to a process for preparing said foams and to the thus obtained foams.
C08J 9/02 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par la réaction des monomères ou par des agents de modification durant la préparation ou la modification des macromolécules
The present invention relates to a herbicidal composition comprising at least one phenolic active compound being myricitrin. The invention also relates to the use of such a herbicidal composition.
A01N 43/42 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons condensés avec des carbocycles
A01N 37/10 - Acides carboxyliques aromatiques ou araliphatiques, ou leurs thio-analoguesLeurs dérivés
76.
Method for the diagnosis of airway disease inflammatory subtype
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE (Belgique)
Inventeur(s)
Schleich, Florence
Louis, Renaud
Bessonov, Kyrylo
Van Steen, Kristel
Van Schooten, Frederik-Jan
Dallinga, Jan
Abrégé
In vitro methods for diagnosing, prognosing and/or monitoring and treating neutrophilic or eosinophilic airway inflammation in a subject, including determining the amount of one or more volatile organic compounds (VOCs) in exhaled breath from said subject. The invention also provides devices for use in said methods.
New pyrimidine derivatives together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-negative bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-negative biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives together with a membrane penetrating agent; for use as radiotracer in diagnosing or prognosing Gram-negative bacterial infection in a host mammal.
C07D 473/24 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 un atome d'azote et un atome de soufre
New pyrimidine derivatives together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-negative bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-negative biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives together with a membrane penetrating agent; for use as radiotracer in diagnosing or prognosing Gram-negative bacterial infection in a host mammal.
C07D 473/24 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 un atome d'azote et un atome de soufre
The present application relates to an agonist of a human kisspeptin receptor for use in a method of treating a disorder of sexual desire in human females, a method of treating a disorder of sexual desire in a human female patient, comprising administering to said patient a therapeutically effective amount of an agonist of a human kisspeptin receptor and a non-therapeutic method of enhancing libido or inducing sexual arousal in a human female subject, comprising administering to said subject an amount of an agonist of a human kisspeptin receptor sufficient to enhance libido in said subject.
A polyvinyl alcohol has a number-average molecular weight (Mn) from 4,400 to 440,000, a molecular weight distribution (Mw/Mn) from 1.05 to 1.70, a degree of saponification from 80 to 99.99 mol %, wherein the polyvinyl alcohol contains an end group represented by a formula (I) below, and a molar ratio (X) of the end group based on total monomer units and the number-average molecular weight (Mn) satisfy a formula (1) below. Such a polyvinyl alcohol has a narrow molecular weight distribution and a high number-average molecular weight with hue good.
X·Mn/44≥0.5 (1)
In a first aspect, the present invention relates to a composite anode material, comprising: (i) a layer of silicon-carbon (Si/C) composite material comprising silicon-carbon composite particles, and (ii) a graphene oxide (GO) layer covering the layer of silicon-carbon composite material; wherein the silicon-carbon composite particles each comprise a plurality of silicon (Si) particles intermixed with a carbon-based material, and wherein the silicon-carbon composite particles comprise a porous shell surrounding a hollow, the porous shell comprising the plurality of silicon particles intermixed with the carbon-based material.
H01M 4/134 - Électrodes à base de métaux, de Si ou d'alliages
H01M 4/1395 - Procédés de fabrication d’électrodes à base de métaux, de Si ou d'alliages
H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif
In a first aspect, the present invention relates to a composite anode material, comprising: (i) a layer of silicon-carbon (Si/C) composite material comprising silicon-carbon composite particles, and (ii) a graphene oxide (GO) layer covering the layer of silicon-carbon composite material; wherein the silicon-carbon composite particles each comprise a plurality of silicon (Si) particles intermixed with a carbon-based material, and wherein the silicon-carbon composite particles comprise a porous shell surrounding a hollow, the porous shell comprising the plurality of silicon particles intermixed with the carbon-based material.
H01M 4/134 - Électrodes à base de métaux, de Si ou d'alliages
H01M 4/1395 - Procédés de fabrication d’électrodes à base de métaux, de Si ou d'alliages
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif
H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
83.
Inducible promoter for gene expression and synthetic biology
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (France)
UNIVERSITE LIBRE DE BRUXELLES (Belgique)
UNIVERSITE DE LIEGE (Belgique)
Inventeur(s)
Nicaud, Jean-Marc
Trassaert, Marion
Thomas, Stephane
Fickers, Patrick
Vandermies, Marie
Carly, Frederic
Abrégé
The invention is related to an inducible promoter for improved and regulated gene expression, useful in synthetic biology and metabolic engineering. In particular, the present invention relates to a nucleotide sequence comprising the regulatory regions of an erythritol- and erythrulose-inducible promoter in yeast and uses thereof in an expression system thus allowing an improved and regulated gene expression and production of gene product.
Microfluidic module (100) for co-encapsulation in droplets of two populations of particles, comprising a first (1) and a second (2) modules for sorting said two populations, said modules (1, 2) having their first outlets (12, 22) comprising first obstructive valves (121, 221) configured to at least partially obstruct said first outlets (12, 22), said first outlets (12, 22) being fluidly connected to: - a fusion module (3) comprising: • a fusion module means (30) for merging at least one droplet from the first droplet population and at least one droplet from the second droplet population into a merged droplet comprising said two population of particles, - a control unit (4) for controlling: • said first obstructive valves (121, 221) from information originating from a first (19) and second (29) module detection portion located upstream of said first outlets (12, 22).
Microfluidic module (100) for co-encapsulation in droplets of two populations of particles, comprising a first (1) and a second (2) modules for sorting said two populations, said modules (1, 2) having their first outlets (12, 22) comprising first obstructive valves (121, 221) configured to at least partially obstruct said first outlets (12, 22), said first outlets (12, 22) being fluidly connected to: - a fusion module (3) comprising: a fusion module means (30) for merging at least one droplet from the first droplet population and at least one droplet from the second droplet population into a merged droplet comprising said two population of particles, - a control unit (4) for controlling: said first obstructive valves (121, 221) from information originating from a first (19) and second (29) module detection portion located upstream of said first outlets (12, 22).
A composition comprises: an at least partially hydrolysed polyvinyl acetate component having an hydrolysation degree of at least 5%; a polyalkylene glycol component having a number average molecular mass Mn lower than 9000 g/mol and consisting of one or more substances selected from the group consisting of polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol and propylene glycol, and their derivatives; a positive or negative electrode active component; and a conductive component; wherein the mass ratio between the at least partially hydrolysed polyvinyl acetate component and the positive or negative electrode active component equals at least 0.12 and at most 0.30, and wherein the mass ratio between the polyalkylene glycol component and the positive or negative electrode active component equals at least 0.012 and at most 0.10.
This apparatus (30) for the production of microalgae comprises a vessel (1) intended to receive a culture medium of the microalgae, and a lighting device (6) intended to be positioned in the vessel inside the culture medium. The lighting device (6) is configured to emit light at least in a range of wavelengths useful for the photosynthesis of the microalgae. The apparatus comprises a control system (15) for automatically controlling a power supply of the lighting device (6) so as to adjust the output light intensity of the lighting device (6) according to the concentration of microalgae in the vessel (1).
This apparatus (30) for the production of microalgae comprises a vessel (1) intended to receive a culture medium of the microalgae, and a lighting device (6) intended to be positioned in the vessel inside the culture medium. The lighting device (6) is configured to emit light at least in a range of wavelengths useful for the photosynthesis of the microalgae. The apparatus comprises a control system (15) for automatically controlling a power supply of the lighting device (6) so as to adjust the output light intensity of the lighting device (6) according to the concentration of microalgae in the vessel (1).
Herbicidal composition comprising at least one essential oil The present invention relates to a herbicidal composition comprising at least one essential oil as an active compound, at least one surfactant and at least one oily substance, said composition being under the form of an emulsion.
A01N 65/12 - Asteraceae ou Compositae [famille de l'aster ou du tournesol], p. ex. marguerite, pyrèthre, artichaut, laitue, tournesol, armoise ou estragon
A01N 65/24 - Lauraceae [famille du laurier], p. ex. laurier, avocat, sassafras, cannelle ou camphre
A01N 65/28 - Myrtaceae [famille du myrte], p. ex. cajeputier ou clou de girofle
A01N 65/44 - Poaceae ou Gramineae [famille des céréales], p. ex. bambou, citronnelle ou verveine des Indes
A01N 25/30 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles caractérisés par les agents tensio-actifs
A computer-implemented method for training a neural network for classifying image data and a related computer program product are disclosed. A labelled input data set comprising a plurality of labelled image data samples is provided together with a neural network. The neural network comprises an input layer, at least one intermediate layer, and an output layer having one channel per label class. Each channel comprises a plurality of neurons of the output layer and is generating a multidimensional feature vector in response to an image data sample presented to the input layer of the neural network. Furthermore, the input layer of a decoder network for reconstructing image data samples at its output is connected to the output layer of the neural network. A classifier predicts class labels as the labels of those channels for which a normed distance of its corresponding feature vector relative to a pre-determined reference point is smallest. A loss function for the neural network is suitable for steering, for each channel, the feature vectors onto which image data samples of the associated class are mapped, into a convex region around the pre-determined reference point.
Herbicidal composition comprising at least one essential oil The present invention relates to a herbicidal composition comprising at least one essential oil as an active compound, at least one surfactant and at least one oily substance, said composition being under the form of an emulsion.
A01N 25/30 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles caractérisés par les agents tensio-actifs
A01N 65/24 - Lauraceae [famille du laurier], p. ex. laurier, avocat, sassafras, cannelle ou camphre
A01N 65/12 - Asteraceae ou Compositae [famille de l'aster ou du tournesol], p. ex. marguerite, pyrèthre, artichaut, laitue, tournesol, armoise ou estragon
A01N 65/44 - Poaceae ou Gramineae [famille des céréales], p. ex. bambou, citronnelle ou verveine des Indes
A01N 65/28 - Myrtaceae [famille du myrte], p. ex. cajeputier ou clou de girofle
BIOTECHNOLOGY CENTER AT THE TECHNOPOLE OF BORJ-CEDRIA (CBBC) (Tunisie)
Inventeur(s)
Ben Kaab, Sofiene
Jijakli, Haissam
Ksouri, Riadh
Parisi, Olivier
Dal Maso, Simon
Abrégé
Herbicidal composition comprising at least one phenolic active compound The present invention relates to a herbicidal composition comprising at least one phenolic active compound being myricitrin. The invention also relates to the use of such a herbicidal composition.
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
93.
Process to prepare an electrode for an electrochemical storage device
A process to prepare an electrode for an electrochemical storage device by spraying an aqueous slurry composition comprising water, xanthan gum, a source of conducting carbon particles and an active material on an electrode base. The slurry may be made by first mixing solid xanthan gum with the conducting carbon particles and the active material and secondly adding water to the resulting mixture. Alternatively the slurry is obtained by mixing solid xanthan gum with a carbon-based active material and adding water to the resulting mixture obtained.
H01M 4/36 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs
H01M 4/1315 - Électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx contenant des atomes d'halogène, p. ex. LiCoOxFy
H01M 4/133 - Électrodes à base de matériau carboné, p. ex. composés d'intercalation du graphite ou CFx
H01M 4/1391 - Procédés de fabrication d'électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx
H01M 4/1393 - Procédés de fabrication d’électrodes à base de matériau carboné, p. ex. composés au graphite d'intercalation ou CFx
H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p. ex. LiNiO2, LiCoO2 ou LiCoOxFy
H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
H01M 10/54 - Récupération des parties utiles des accumulateurs usagés
H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
H01M 4/587 - Matériau carboné, p. ex. composés au graphite d'intercalation ou CFx pour insérer ou intercaler des métaux légers
H01M 4/1397 - Procédés de fabrication d’électrodes à base de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFy
H01M 4/485 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques d'oxydes ou d'hydroxydes mixtes pour insérer ou intercaler des métaux légers, p. ex. LiTi2O4 ou LiTi2OxFy
H01M 4/136 - Électrodes à base de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFy
H01M 4/1395 - Procédés de fabrication d’électrodes à base de métaux, de Si ou d'alliages
H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
H01M 4/131 - Électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx
94.
Method of early diagnosis of immune-mediated inflammatory disease
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE (Belgique)
Inventeur(s)
Malaise, Michel
De Seny, Dominique
Abrégé
An in-vitro method for early diagnosing or prediction of immune-mediated inflammatory diseases, comprising: —obtaining a sample from a subject; —quantifying simultaneously by one LC/MS-MS analysis of said sample, a presence of V65 vitronectin fragment or fragment, variant or degradation product thereof; and a presence of a complement C3f or fragment or variant or degradation products thereof.
G01N 33/564 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
The present application relates to methods for determining the proportion or quantity of DNA contributed by individual animals to a volume of milk collected from a plurality of individual animals, wherein the method employs allele sampling for DNA sequence polymorphisms in DNA extracted from a sample of the volume of milk by shallow whole genome sequencing (SWGS). The present methods are useful for example in detecting mastitis or subclinical mastitis in animals contributing milk to the volume of milk.
C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
The present application relates to methods for determining the proportion or quantity of DNA contributed by individual animals to a volume of milk collected from a plurality of individual animals, wherein the method employs allele sampling for DNA sequence polymorphisms in DNA extracted from a sample of the volume of milk by shallow whole genome sequencing (SWGS). The present methods are useful for example in detecting mastitis or subclinical mastitis in animals contributing milk to the volume of milk.
C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
97.
HERBICIDAL COMPOSITION COMPRISING AT LEAST ONE PHENOLIC ACTIVE COMPOUND
FACULTE DES SCIENCES MATHEMATIQUES, PHYSIQUES ET NATURELLES DE TUNIS (Tunisie)
BIOTECHNOLOGY CENTER AT THE TECHNOPOLE OF BORJ-CEDRIA (CBBC) (Tunisie)
Inventeur(s)
Ben Kaab, Sofiene
Jijakli, Haissam
Ksouri, Riadh
Parisi, Olivier
Dal Maso, Simon
Abrégé
The present invention relates to a herbicidal composition comprising at least one phenolic active compound being myricitrin. The invention also relates to the use of such a herbicidal composition.
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
A01N 25/30 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles caractérisés par les agents tensio-actifs
A process to prepare an electrode for an electrochemical storage device by spraying an aqueous slurry composition comprising water, xanthan gum, a source of conducting carbon particles and an active material on an electrode base. The slurry may be made by first mixing solid xanthan gum with the conducting carbon particles and the active material and secondly adding water to the resulting mixture. Alternatively the slurry is obtained by mixing solid xanthan gum with a carbon-based active material and adding water to the resulting mixture obtained.
H01M 4/36 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs
H01M 4/1315 - Électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx contenant des atomes d'halogène, p. ex. LiCoOxFy
H01M 4/133 - Électrodes à base de matériau carboné, p. ex. composés d'intercalation du graphite ou CFx
H01M 4/1391 - Procédés de fabrication d'électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx
H01M 4/1393 - Procédés de fabrication d’électrodes à base de matériau carboné, p. ex. composés au graphite d'intercalation ou CFx
H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p. ex. LiNiO2, LiCoO2 ou LiCoOxFy
H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
H01M 10/54 - Récupération des parties utiles des accumulateurs usagés
H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
H01M 4/587 - Matériau carboné, p. ex. composés au graphite d'intercalation ou CFx pour insérer ou intercaler des métaux légers
H01M 4/1397 - Procédés de fabrication d’électrodes à base de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFy
H01M 4/485 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques d'oxydes ou d'hydroxydes mixtes pour insérer ou intercaler des métaux légers, p. ex. LiTi2O4 ou LiTi2OxFy
H01M 4/136 - Électrodes à base de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFy
H01M 4/1395 - Procédés de fabrication d’électrodes à base de métaux, de Si ou d'alliages
H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
H01M 4/131 - Électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx
99.
HERBICIDAL COMPOSITION COMPRISING AT LEAST ONE PHENOLIC ACTIVE COMPOUND
BIOTECHNOLOGY CENTER AT THE TECHNOPOLE OF BORJ-CEDRIA (CBBC) (Tunisie)
Inventeur(s)
Ben Kaab, Sofiene
Jijakli, Haissam
Ksouri, Riadh
Parisi, Olivier
Dal Maso, Simon
Abrégé
The present invention relates to a herbicidal composition comprising at least one phenolic active compound being myricitrin. The invention also relates to the use of such a herbicidal composition.
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
100.
PYRIMIDINE DERIVATIVES FOR PREVENTION AND TREATMENT OF BACTERIAL INFECTIONS
New pyrimidine derivatives of formula (I), optionally with a detectable isotope, pharmaceutical composition and method of preparation thereof. New pyrimidine derivatives for use in treatment or prevention of bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives for use as radiotracer in diagnosing or prognosing bacterial infection in a host mammal.
C07D 473/24 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 un atome d'azote et un atome de soufre
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
C07D 473/18 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 un atome d'oxygène et un atome d'azote, p. ex. guanine