Abrégé

The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRD and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRD and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein). The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRD and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein). The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

Classes IPC  ?

• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 49/00 - Préparations pour examen in vivo
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres

Abrégé

The present invention relates to a FUBP1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of FUBP1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules, such as oligonucleotides including siRNA, shRNA and antisense oligonucleotides, which are complementary to FUBP1 and capable of reducing a FUBP1 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides

Abrégé

The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. 1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein). The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

Classes IPC  ?

• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 49/00 - Préparations pour examen in vivo
• B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
• B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

A compression method includes simplifying a mesh that represents a textured 3D-object by replacing polygons in the mesh with new ones that have broader faces. The method includes identifying adjacent polygons with different textures and adding vertices at the same positions as two vertices in the polygons. This creates two new edges and an intermediate polygon interposed between the two adjacent polygons. The new edges have zero length and the new polygon has zero area.

Classes IPC  ?

• G06T 9/00 - Codage d'image
• G06T 17/20 - Description filaire, p. ex. polygonalisation ou tessellation
• G06T 15/04 - Mappage de texture

Abrégé

The device (2) is capable of: - calculating a spectral power PSPG(t) of alpha waves measured uniquely inside a right or left central zone, the right and left central zones being the surfaces of the skull of the patient which contain, respectively, only positions C3, C5, C5h, FCC5h, CCP5h and positions C4, C6, C6h, FCC6h, CCP6h of the nomenclature of the 10-5 system, - determining a mean level NMPG of the spectral power of the alpha waves measured uniquely inside the right or left central zone, - verifying the following condition: PSPG(t) ≤ S1 x NMPG for a least one of the central zones, where S1 is a predetermined positive coefficient less than 0.9, and - triggering the signalling of a pain felt by the patient only if the condition is verified.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/048 - Détection de la répartition de fréquence dans les signaux

Abrégé

This method comprises: - the estimation (102), on the basis of the reflectance of an object, of at least one parameter chosen from the group composed of: a volume fraction of melanin contained in a layer of epidermis, a volume fraction of haemoglobin contained in a layer of the dermis, a proportion of melanin present in eumelanin form, a proportion of melanin present in pheomelanin form, a proportion of haemoglobin present in the form of oxygenated haemoglobin, a proportion of haemoglobin present in the form of deoxygenated haemoglobin, a thickness of the layer of epidermis, and a thickness of the layer of the dermis; - the automatic classification (104) of this object in one or other of the following categories depending on said at least one parameter estimated: a category containing skins from a living human being and a category containing inanimate decoys of human skins.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

A copolymer containing a unit including an optionally neutralized styrene sulphonic acid unit and a unit containing at least one optionally neutralized (poly)carboxylic acid unit or a (poly)amido-amine unit, to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil. It also relates to a method to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil, including the injection of a fluid containing the abovementioned copolymer into a wellbore, a subterranean formation or a gas or oil well.

Classes IPC  ?

• C09K 8/54 - Compositions pour inhiber in situ la corrosion dans les puits ou les trous de forage
• C09K 8/532 - Soufre
• C08F 12/30 - Soufre
• E21B 37/06 - Procédés ou appareils pour nettoyer les trous de forage ou les puits utilisant des moyens chimiques pour empêcher ou limiter le dépôt de paraffine ou de substances analogues

Abrégé

The invention relates to a method for compressing data representing a digital three-dimensional object, comprising: acquiring a three-dimensional object comprising a mesh formed from a plurality of polygons (12, 14), and a texture atlas of the polygons of the mesh, and simplifying the mesh by deletion of vertices, which deletes polygons and replaces same with new polygons having a broader face; and wherein, before the deletion of the vertices, the method comprises: identifying first (12) and second (14) adjacent polygons with different textures in the mesh, then splitting the first (B) and second (C) shared vertices by creating third (B') and fourth (C') vertices.

Classes IPC  ?

• G06T 9/00 - Codage d'image
• G06T 17/20 - Description filaire, p. ex. polygonalisation ou tessellation

Abrégé

The invention relates to a method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. The invention also relates to the use of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.

Classes IPC  ?

• E21B 37/06 - Procédés ou appareils pour nettoyer les trous de forage ou les puits utilisant des moyens chimiques pour empêcher ou limiter le dépôt de paraffine ou de substances analogues
• C09K 8/528 - Compositions pour éviter, limiter ou éliminer les dépôts, p. ex. pour le nettoyage les dépôts inorganiques, p. ex. sulfates ou carbonates
• E21B 47/10 - Localisation des fuites, intrusions ou mouvements du fluide
• C09K 8/54 - Compositions pour inhiber in situ la corrosion dans les puits ou les trous de forage

Abrégé

The present invention relates to the use of a copolymer containing a unit comprising an optionally neutralised styrene sulphonic acid unit and a unit containing at least one optionally neutralised (poly)carboxylic acid unit or a (poly)amido-amine unit, to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil. It also relates to a method to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil, comprising the injection of a fluid containing the abovementioned copolymer into a wellbore, a subterranean formation or a gas or oil well.

Classes IPC  ?

• C09K 8/532 - Soufre
• C08L 25/04 - Homopolymères ou copolymères du styrène

Abrégé

This invention relates to an electronic system including a radiative electromagnetic emitter for emitting an activation signal including sequentially an energy supply signal followed by an identification signal, the power of the energy supply signal being at least ten times greater than the power of the identification signal, further including an interface connected to an energy supply source; an electric load; a circuit for deactivating a placing of electric load on standby, including: a receiver including a reception interface, a rectifier configured to generate a DC activation voltage on the basis of an activation signal, a switch configured to selectively connect/disconnect to the load from the energy supply, an identification circuit configured to extract an identifier of the activation signal and configured to apply the activation voltage as closure control signal for turning off the switch if a match of the identifier is determined.

Classes IPC  ?

• H02J 5/00 - Circuits pour le transfert d'énergie électrique entre réseaux à courant alternatif et réseaux à courant continu
• H02M 7/217 - Transformation d'une puissance d'entrée en courant alternatif en une puissance de sortie en courant continu sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
• H04W 52/02 - Dispositions d'économie de puissance

Abrégé

The invention relates to a fibre-optic component (1) including: - an optical fibre (3), - at least one cylindrical interferential mirror (5) incorporated into the optical fibre (3) and made up of longitudinal inclusions (7) made from a material having a refraction index n greater than or equal to two times the refraction index n of the optical fibre (3).

Classes IPC  ?

• G02B 6/02 - Fibres optiques avec revêtement

Abrégé

The invention concerns a radio antenna, comprising - a dielectric substrate (8); - an electrically conductive track (10), of width W, extending longitudinally between two terminal ends (20, 22), only within a strip (24) of width L delimited, on one side, by an outer limit (26) and, on the other side, by an inner limit (28), said limits each forming a closed loop; and in which: - the track defines a periodic "U"- or "V"-shaped pattern (30), repeated N times, and comprising strands of track, separated from each other by a spacing distance S and forming side bars of the "U" or "V", -L is less than 5 mm; -N is greater than 3; -W is greater than or equal to 0.15 mm; -S is greater than or equal to 0.01 mm.

Classes IPC  ?

• H01Q 1/22 - SupportsMoyens de montage par association structurale avec d'autres équipements ou objets
• H01Q 1/38 - Forme structurale pour éléments rayonnants, p. ex. cône, spirale, parapluie formés par une couche conductrice sur un support isolant
• H01Q 7/00 - Cadres ayant une distribution du courant sensiblement uniforme et un diagramme de rayonnement directif perpendiculaire au plan du cadre
• H01Q 19/13 - Combinaisons d'éléments actifs primaires d'antennes avec des dispositifs secondaires, p. ex. avec des dispositifs quasi optiques, pour donner à une antenne une caractéristique directionnelle désirée utilisant des surfaces réfléchissantes où les surfaces sont concaves la source rayonnante primaire étant un élément rayonnant unique, p. ex. un dipôle, une fente, une terminaison de guide d'onde

Abrégé

A method for the localised transfer of a palladium species onto a substrate by pad printing, said method comprising the preparation (52) of an intermediate layer of molecules covering a contact face of a pad, said molecules each comprising a main chain, one end of said main chain ending in a less polar group and an opposite end of this main chain ending in a more polar group, the more polar group being chosen from the group consisting of thiols, amines, phosphines and disulphides, the less polar group having a polarity that is strictly lower than that of the more polar group, such that these molecules are only fixed to the contact face by means of Van Der Waals forces and such that the palladium species to be transferred bonds with the more polar group of the molecules, the main chain being a hydrocarbon chain comprising fewer than twenty carbon atoms.

Classes IPC  ?

• B05D 1/28 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par transfert de liquides ou d'autres matériaux fluides, à partir de la surface d'éléments porteurs, p. ex. de pinceaux, tampons, rouleaux
• C23C 18/30 - Activation
• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
• B05D 1/18 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par immersion

Abrégé

A method of pad printing comprising: a) preparing (52) a self-assembled layer of molecules covering a contact face of the pad, a self-assembled layer being a layer in which the main chains of the self-assembled molecules are parallel to each other and form an angle α that is strictly less than 90° with the direction normal to the contact face, less polar groups of the self-assembled molecules being adsorbed on the contact face and more polar groups being turned outward from the pad such that the wettability of the contact face covered with the self-assembled layer corresponds to an angle of contact with distilled water of which the value is less than 70°, b) then, following step a), moving (62) the pad to bring the self-assembled layer into contact with the face to be printed, and c) next, removing (66) the pad to leave the self-assembled layer on the face to be printed.

Classes IPC  ?

• B05D 1/18 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par immersion
• B05D 1/28 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par transfert de liquides ou d'autres matériaux fluides, à partir de la surface d'éléments porteurs, p. ex. de pinceaux, tampons, rouleaux
• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
• G03F 7/16 - Procédés de couchageAppareillages à cet effet
• B05D 1/20 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par immersion les substances à appliquer flottant sur un fluide

Abrégé

The invention relates to a method for automatically estimating a value SPT,E ( D) of a survival rate of biological cells irradiated by a dose D of a first ionising radiation comprising particles of type T and energy E, said cells having a partial oxygen pressure P. Said method comprises: determining (150) a quantity Qi representing a quantity of a given chemical species R, produced by radiolysis of the intracellular medium of the biological cells under the effect of the dose D of the first ionising radiation, when said cells have the partial oxygen pressure P; and determining (152) a dose D' of a second ionising radiation to be applied to the biological cells in order to obtain the same quantity Qi, by radiolysis of said cellular medium, when said cells have a partial oxygen pression P2.

Classes IPC  ?

• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
• A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules

Abrégé

The invention proposes a method for identifying cells in a biological tissue, each cell including a cytoplasm defined by a cell membrane, the method comprising: a) acquiring (10) a raw digital image of a section of the biological tissue containing the cells to be identified, said raw image comprising a plurality of pixels having different intensity values; b) automatically generating (30, 60, 80) at least one thresholded image; c) automatically searching (40, 70, 90), in the thresholded image, for surfaces each formed from a plurality of contiguous pixels and having the same predefined intensity value, each surface found in this way constituting a candidate cell. According to the invention, the predefined intensity value is whichever of the first and second intensity values corresponds to the cytoplasm.

Classes IPC  ?

• G06T 7/00 - Analyse d'image

Abrégé

The invention concerns a reactor (2) for implementing a nuclear fusion reaction, comprising: -a heat transfer liquid containing (4) first (10) and second (12) atomic elements in solution; - a bubble generator (6) capable of creating a bubble (14) in the heat transfer liquid, said bubble enclosing a gaseous medium (15) containing at least the first atomic element; - a laser source (8) designed to apply a femtosecond laser pulse (18) to the heat transfer liquid, directed at the bubble and having a duration of less than 100fs and an intensity greater than 1014 W.cm-2, to trigger a coulomb explosion in the gaseous medium, said explosion accelerating atomic nucleii of said first atomic elements to trigger a nuclear fusion reaction between atomic nucleii of the first and second atomic elements.

Classes IPC  ?

• G21B 3/00 - Réacteurs de fusion nucléaire à basse température, p. ex. réacteurs de fusion dite froide

Abrégé

The invention concerns a motor vehicle drive unit, comprising: a fuel cell (3) comprising a flat nonlinear control whereof control input Ppac* is a setpoint of the electrical power to be delivered by the fuel cell; a reversible electrical energy storage system (2); an electric motor (4); an electrical connection element (11) configured to selectively connect the fuel cell and/or the energy storage system to the electric motor (4); a control circuit (5, 31): - memorising a model of the dihydrogen consumption of the fuel cell on the basis of the electrical power delivered by said fuel cell g(Ppac*) = a*Ppac*2 + b*Ppac* + c; - configured to calculate a coefficient of power distribution between the fuel cell and the storage system: formula (K) - configured to apply power setpoint Ppac*, where Ppac*=(λ1-b)/(2a).

Classes IPC  ?

• B60L 11/18 - utilisant de l'énergie fournie par des piles primaires, des piles secondaires ou des piles à combustibles

Abrégé

The invention relates to a device (1) for assessing cognitive abilities, including: a display device (3); a testing device (2) configured to determine the location of the display device watched by an eye of the patient and to automatically carry out the following sequence: the display (3) of a test visual; the determination of the number of transitions of the gaze between a matrix and answer choices; and the repetition of the sequence for a plurality of test visuals.

Classes IPC  ?

• A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
• A61B 3/113 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour déterminer ou enregistrer le mouvement de l'œil
• G09B 5/00 - Matériel à but éducatif à commande électrique

Abrégé

The invention concerns a circuit (2) in which each trajectory portion (6) - is contained in a square (4), - starts at an apex of the square or in the middle of a side of the square at a point A and ends at another apex of the square or in the middle of another side of the square at a point B, - is tangent at A and at B to the lines respectively linking the centre of the square to points A and B, - necessarily belongs to one of six different sets of trajectory portions, the circuit comprising, for each portion (6), only one guide piece capable of guiding the vehicle along this trajectory portion. The circuit comprises at least five trajectory portions, each belonging to a respective set different from the sets to which the other trajectory portions of the six possible sets belong.

Classes IPC  ?

• A63H 18/02 - Construction ou disposition de la voie de roulement
• A63H 19/28 - Systèmes de trains mécaniques

Abrégé

The invention relates to an electronic system (1), comprising: - a radiative electromagnetic emitter (2) for emitting an activation signal including sequentially an energy supply signal followed by an identification signal, the power of the energy supply signal being at least ten times greater than the power of the identification signal; - an interface connecting to an energy supply source (6); - an electric load (71); - a circuit (5) for deactivating a placing of the electric load on standby, including: - a receiver (3) comprising: - a reception interface; - a rectifier configured to generate a DC activation voltage on the basis of an activation signal; - a switch (4) configured to selectively connect/disconnect the load (71) from the energy supply; - an identification circuit configured to extract an identifier of the activation signal and configured to apply the activation voltage as closure control signal for turning off the switch (4) if a match of the identifier is determined.

Classes IPC  ?

• G06F 1/32 - Moyens destinés à économiser de l'énergie
• H04W 52/02 - Dispositions d'économie de puissance

Abrégé

The invention relates to a field-emission electron source, comprising an electron-emitting tip (12-14), the greatest width of the cross-section of which is greater than 0.4 mm, wherein the outer surface of said tip is made of a composite material consisting of a matrix of an electrically insulating material, inside which and at the surface of which carbon particles are randomly distributed so as to render the tip electrically conductive. The carbon particles constitute less than 40 wt % of the composite material. The carbon particles are carbon-black particles having a specific surface area of more than 150 m2/g, or graphite-powder particles, and the tip is made entirely of said composite material.

Classes IPC  ?

• H01J 49/14 - Sources d'ionsCanons à ions utilisant un bombardement de particules, p. ex. chambres d'ionisation
• H01J 1/304 - Cathodes à émission d'électrons de champ
• H01J 9/02 - Fabrication des électrodes ou des systèmes d'électrodes
• H01J 3/02 - Canons à électrons

Abrégé

The invention relates to a method for characterizing an electronic system to be included in an electronic integrated circuit, wherein the method comprises the steps of: recovering respective digital simulation models (50B, 50C) of first and second blocks; recovering a digital simulation model of the system (50A) including said first and second blocks; applying, to the digital simulation model of the system (50A), various concurrent performance metric values of the blocks, which belong to various validity domains, so as to generate performance metric values of the system; generating a function representative of a Pareto frontier and defining a second of said output performance metrics of the system on the basis of a first of said output metrics of the system; and generating a function defining performance metric values of the blocks on the basis of the output metric of the system.

Classes IPC  ?

• G06F 17/50 - Conception assistée par ordinateur

Abrégé

The invention relates to a device for measuring currents (3) in the conductors of a sheathed cable of a polyphase network, comprising at least three magnetic sensors (300) arranged around a central hole (312) through which the cable to be measured is intended to pass, the number of conductors in said cable being less than the number of sensors, and a calculation device (330) configured to: access a library of matrices [K] and [K]+, where [K]+ is a pseudo-inverse matrix of matrix [K]; form a vector [B] including a magnetic field measurement for each of the sensors; for various cable configurations and various angular positions of the sensors relative to the cables, calculate a residual vector [R] = [K].[K]+.[B] - [B]; select the matrix [K]+ for which the norm of the vector [R] is minimal; and calculate [1] = [K]+.[B], where [K]+ is the selected matrix.

Classes IPC  ?

• G01R 15/20 - Adaptations fournissant une isolation en tension ou en courant, p. ex. adaptations pour les réseaux à haute tension ou à courant fort utilisant des dispositifs galvano-magnétiques, p. ex. des dispositifs à effet Hall

Abrégé

This method of establishing a final score of similarity between a digital image acquired and a pre-recorded digital image, comprises: a) the construction (42) on the basis of the image acquired of H maps Ji, of gradients calculated according to a respective set i of directions, b) for each map of gradients Ji, the calculation (52) of an intermediate score Si, of similarity between this map of gradients Ji, and a corresponding reference map Jiref, each intermediate score Si of similarity being a real number representing the degree of similitude between the compared maps, the reference map Jiref being a map of gradients calculated according to the same set i of directions as the map of gradients Ji, on the basis of the pre-recorded image, and c) the establishment (54) of a final score Sf of similarity between the image acquired and the pre-recorded image as a function of the H intermediate scores Si of similarity.

Classes IPC  ?

• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• G06K 9/46 - Extraction d'éléments ou de caractéristiques de l'image

Abrégé

A ion source comprises: - a chamber (45), - an injection to inject matter into the chamber, wherein said matter comprises at least a first species, a tip with an apex located in the chamber, wherein the apex has a surface made of a metallic second species, - a generator to generate ions of said species, - a regulation system adapted to set operative conditions of the chamber to alternatively generate ions from the gaseous first species, and ions from the non¬ gaseous metallic second species.

Classes IPC  ?

• H01J 37/08 - Sources d'ionsCanons à ions
• H01J 37/305 - Tubes à faisceau électronique ou ionique destinés aux traitements localisés d'objets pour couler, fondre, évaporer ou décaper

Abrégé

The invention relates to an aid (1) for controlling the blood glucose level of a patient, including: an interface (4) for inputting the glycated hemoglobin level of a patient and for inputting the blood glucose level of the patient; computing means (61) for automatically determining a target blood glucose level for the patient on the basis of the inputted glycated hemoglobin level, comparing the determined target blood glucose level with the inputted blood glucose level, and determining an amount of insulin to be administered to the patient on the basis of the comparison results.

Classes IPC  ?

• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang

Abrégé

Pumping installation for obtaining a high vacuum and pumping method using such an installation. Specifically, the invention relates to a pumping installation comprising: a chamber (5), first and second vacuum pumps (PAV1, PAV2), and a distribution circuit designed to continuously measure a first pressure (P1) at the inlet of the second vacuum pump (PAV2) and a second pressure (P2) in the chamber (5). If one of the pressures chosen from the first pressure (P1) and the second pressure (P2) is higher than a threshold pressure (Ps), a low vacuum is established with the action of the first vacuum pump (PAV1) alone, otherwise, a high vacuum is established with the first and second vacuum pumps (PAV1, PAV2) acting in series.

Classes IPC  ?

• F04B 37/14 - Pompes spécialement adaptées aux fluides compressibles et ayant des caractéristiques pertinentes non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes pour utilisation particulière pour obtenir un vide élevé
• F04B 49/22 - Commande des "machines", pompes ou installations de pompage ou mesures de sécurité les concernant non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes par clapets
• C23C 14/56 - Appareillage spécialement adapté au revêtement en continuDispositifs pour maintenir le vide, p. ex. fermeture étanche
• F04D 27/00 - Commande, p. ex. régulation, des pompes, des installations ou des systèmes de pompage spécialement adaptés aux fluides compressibles

Abrégé

The invention relates to a method for dynamically determining the position and orientation of the bone elements of the spine of a person by internal imaging, in particular radiological imaging by digitizing 2D radiographs of the spine, and by the external 3D imaging of the rear of the trunk of said person and calculations in a computing means. According to the invention, in a first stage t, the relationships of the vertebrae to one another and relative to the surface of the back are calculated, and then equations are determined for a dynamic mechanical model of the spine and for internal stresses on the spine and interactions between the spine and the surface of the back, and, in a second stage t+1, 3D images of the outer surface of the back of said person are produced, and, for said stage t+1, the position and orientation of each of the vertebrae are determined from data acquired from 3D images of the outer surface of the back during stage t+1 and from static position and orientation data calculated for each of the vertebrae as well as for the shape of the surface of the back during stage t, by solving the dynamic model of the spine represented by the equations thereof with the application of forces and stresses established from the data acquired at t+1 and calculated at t, the forces and stresses being internal forces and stresses on the spine and forces and stresses from interactions of the spine with the surface of the back.

Classes IPC  ?

• G06T 7/20 - Analyse du mouvement

Abrégé

The invention relates to novel biocompatible hybrid nanoparticles of very small size that are of use in particular for diagnosis and/or therapy. The objective of the invention is to provide novel nanoparticles which are of use in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which are more effective than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high metal (e.g. rare earth) loading rate, in particular so as to have, in imaging (e.g. MRI), a strong enhancement and a correct response (increased relaxivity) at high frequencies. Thus, the nanoparticles according to the invention, of diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations, optionally associated with doping cations; a DTPABA (diethylenetriaminepentaacetic acid bisanhydride) chelating C1 graft bonded to the POS matrix via -Si-C- covalent bonding, and present in sufficient amount to be able to complex all the gadolinium cations; and optionally an other functionalization graft Gf* bonded to the POS matrix via -Si-C- covalent bonding (it being possible for Gf* to result from a hydrophilic compound (PEG); from a compound comprising an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein)). The method for obtaining these nanoparticles and the uses thereof in imaging and in therapy are also part of the invention.

Classes IPC  ?

• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
• B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires

Abrégé

The invention relates to a novel method for producing methane gas in situ, wherein: at least one natural kerogen-rich layer is selected from the superficial geological subsoil down to a depth of 1,500 m, the growth and activity of the indigenous microorganisms naturally contained in said kerogens are stimulated in order to increase methane production, and the methane produced is extracted. The method can include a step comprising the injection of fluids in order to increase the production of methane in the kerogens, said fluids comprising at least water, nutrients for the syntroph and methanogenic microorganisms, and at least one additive. Reference is also made to the nutrient composition forming part of said fluids, as well as compositions of trace elements, vitamin solution and inhibitors of indigenous microbiological populations, each of which forms part of said nutrient composition. The methane production method can include a preliminary prospecting phase for selecting at least one layer having a high gas potential at a given geological site.

Classes IPC  ?

• E21B 43/22 - Emploi de produits chimiques ou à activité bactérienne
• E21B 43/25 - Procédés pour activer la production
• C12P 5/02 - Préparation des hydrocarbures acycliques
• C09K 8/60 - Compositions pour activer la production en agissant sur la formation souterraine
• C09K 8/582 - Compositions pour les méthodes de récupération assistée pour l'extraction d'hydrocarbures, c.-à-d. pour améliorer la mobilité de l'huile, p. ex. fluides de déplacement caractérisées par l'utilisation de bactéries
• C12N 1/38 - Stimulation chimique de la croissance ou de l'activité par addition de composés chimiques qui ne sont pas des facteurs essentiels de croissanceStimulation de la croissance par élimination d'un composé chimique
• C12N 1/28 - Procédés utilisant des hydrocarbures ou milieux de culture en contenant aliphatiques

Abrégé

This guide device comprises: - a wall (20) such as to have a wettability that is modifiable from a value θ1 to a value θ2 in response to a control signal and this wall being shaped in such a way that the liquid flows along this wall: - for a distance d1 in the direction of flow before detaching from the wall when the wettability has the value θ1, and - for a distance d2 in the direction of flow before detaching from the wall when the wettability has the value θ2, and - a control unit (30) suitable for generating a control signal to modify the wettability of the wall from the value θ1 to the value θ2.

Classes IPC  ?

• F15D 1/00 - Action sur l'écoulement des fluides

Abrégé

The invention relates to a machine for machining a part by micro-electrical discharge machining, said machine comprising a mechanism (44, 45, 46, 48) for modifying the configuration of the machine so as to alternatively and reversibly switch from a machining configuration to a sharpening configuration in which the tip of a same etching electrode (20) and another electrode (64) are dipped in an electrolyte bath in order to sharpen the tip of the etching electrode by electrochemical corrosion.

Classes IPC  ?

• B23H 3/04 - Électrodes spécialement adaptées à cet effet ou leur fabrication
• B23H 9/00 - Usinage spécialement conçu pour le traitement d'objets métalliques particuliers ou pour obtenir des effets ou des résultats particuliers sur des objets métalliques
• B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat