Nucleoside analogues and compositions containing said nucleoside analogues are provided, according to a general formula (I) disclosed herein. Processes are provided for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the diagnosis, prevention and/or treatment of parasitic infections, more specifically for use in the diagnosis, prevention and/or treatment of a Trypanosoma infection.
A61K 31/7064 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées
C07H 19/23 - Radicaux hétérocycliques contenant au moins deux hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, non prévus dans les groupes
The current invention relates to a method for methanol production, wherein the method comprises the steps of: a) supplying one or more gaseous input streams to a plasma reactor, wherein the one or more gaseous input streams comprise at least CO2 and CH4, b) igniting a plasma in the plasma reactor, thereby dry reforming said CH4 to form a syngas comprising CO and H2, c) supplying said syngas to a methanol reactor, wherein said CO and H2 in the syngas are at least partially converted to a liquid phase comprising at least methanol, wherein said plasma outlet and said methanol reactor inlet are fluidly connected, and in that said gaseous input streams comprise a total amount of CH4 and a total amount of CO2 in a volume ratio of at least 2.
C07C 29/151 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par réduction exclusivement des oxydes de carbone avec de l'hydrogène ou des gaz contenant de l'hydrogène
The current invention relates to a method for methanol production, wherein the method comprises the steps of: (a) supplying one or more gaseous input streams to a plasma reactor, wherein the one or more gaseous input streams comprise at least CO2, H2O and CH4, (b) igniting a plasma in the plasma reactor, thereby allowing the CO2, H2O and CH4 to react and form syngas comprising CO and H2, (c) supplying said syngas to a methanol reactor, wherein said CO and H2 in the syngas are at least partially converted to methanol in said methanol reactor.
C07C 29/151 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par réduction exclusivement des oxydes de carbone avec de l'hydrogène ou des gaz contenant de l'hydrogène
The present disclosure relates to a plasma reactor for plasma-based gas conversion comprising a pin electrode extending along a longitudinal axis from a first end to a second end, an opposing electrode opposing a discharge tip of the 10 pin electrode, a plasma chamber for confining a glow discharge plasma, and an electrically-insulating body that comprises an inner bore extending along the longitudinal axis from a bore entrance to a bore exit. The second end of the pin electrode comprises a discharge tip. The pin electrode penetrates the inner bore from the bore entrance and extends at least partly through the inner bore and a15 radial wall of a portion of the inner bore located between the second end of the pin electrode and the opposing electrode, is radially delimiting the plasma chamber. The plasma reactor is further configured for varying an electrode separation distance between the discharge tip of the pin electrode and the opposing electrode.
B01J 19/08 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
C01B 3/34 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés organiques gazeux ou liquides avec des agents gazéifiants, p. ex. de l'eau, du gaz carbonique, de l'air par réaction d'hydrocarbures avec des agents gazéifiants
A process for the production of ammonium nitrate from water and a N2 and O2 including gas. The process relates to a system or method for electrified production of ammonium nitrate from air and water (for instance water comprised in the air). A certain aspect of the process is the use of ambient air surroundings in an apparatus to produce ammonium nitrate thereof.
A continuous flow reaction device (100) for an electrochemical process comprising: a reaction space (110), a pumping system (200) configured to generate a pulsatile flow, a plurality of discrete protrusions (120,a: 120,b) each configured such that a flow path (150a-150c) of the fluid contacting an inlet end (14) side of the discrete protrusion is split at least into two daughter flow paths (150b1; 150b2) on the outlet end (16) side of the discrete protrusion (120,a: 120,b); and the discrete protrusions (120,a: 120,b) being arranged so that at least one of the daughter flow paths (150b1) generated by one of the plurality of discrete protrusions (120) combines (152a) with at least one of the daughter flow paths (150a2) generated by another of the plurality of discrete protrusions (120) on the outlet end (16) side of both discrete protrusions (120) and wherein each (and every) discrete protrusion (120) is an electrode in the electrochemical process.
The present invention relates to a water treatment system and method, in particular a wastewater treatment system and method. The water treatment system combines the use of aeration membranes and filtration membranes which are periodically scoured, depending on the oxidative status of the water.
Force measuring device for measuring a force magnitude and a force direction applied to at least one body, wherein the force measuring device comprises a static portion including a connecting element configured to be connected to said at least one body; a dynamic portion; and at least two sensors configured to measure a tractive force and a pressure force or at least four sensors configured to measure one of a tractive force and a pressure force, each of said sensors being positioned between said static portion and said dynamic portion at a radial distance of said connecting element.
G01L 5/16 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques pour la mesure de plusieurs composantes de la force
A63B 69/16 - Appareils d'entraînement ou appareils destinés à des sports particuliers pour cyclisme
G01L 5/22 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques pour la mesure de la force appliquée aux organes de commande, p. ex. organes de commande des véhicules, détentes
A method of transferring a graphene layer onto a target substrate or support structure. The method includes obtaining a metal foil onto which the graphene layer is provided, stabilizing the graphene layer by applying a layer of a cellulose-based polymer onto the graphene layer, and placing the metal foil with the graphene and the polymer layers in or on an etching solution to dissolve the metal foil supporting the graphene layer. The method includes diluting and/or neutralizing the etching solution after the metal foil has been dissolved, and depositing the graphene layer onto the target by placing the target underneath the graphene layer and removing the diluted and/or neutralized solution until the graphene layer settles onto the target. The method includes a dry cleaning of the target to remove the polymer layer by embedding the target in activated carbon and heating.
B32B 37/00 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons
B32B 9/00 - Produits stratifiés composés essentiellement d'une substance particulière non couverte par les groupes
B32B 9/04 - Produits stratifiés composés essentiellement d'une substance particulière non couverte par les groupes comprenant une telle substance comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique
B32B 38/00 - Opérations auxiliaires liées aux procédés de stratification
B32B 38/10 - Enlèvement de couches ou de parties de couches, mécaniquement ou chimiquement
C23C 16/01 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] sur des substrats temporaires, p. ex. sur des substrats qui sont ensuite enlevés par attaque chimique
Network slice orchestration includes deploying both a performance monitor and a slice orchestrator in a core network of a host cellular telecommunications network and defining network slices therein, each with a different set of network resources accessible by different application instances executing at an edge portion of the host cellular telecommunications network. Thereafter, performance data is received from the performance monitor in respect to a particular mobile device accessing a corresponding application instance through an assigned network slice. The slice orchestrator then determines a mismatch in the performance data with respect to an expected performance for the application instance. Finally, in response to the determined mismatch, the slice orchestrator selects a different network slice and re-assigns the application instance to the different network slice.
H04L 41/0897 - Capacité à monter en charge au moyen de ressources horizontales ou verticales, ou au moyen d’entités de migration, p. ex. au moyen de ressources ou d’entités virtuelles
H04L 41/40 - Dispositions pour la maintenance, l’administration ou la gestion des réseaux de commutation de données, p. ex. des réseaux de commutation de paquets en utilisant la virtualisation des fonctions réseau ou ressources, p. ex. entités SDN ou NFV
H04L 41/5025 - Pratiques de respect de l’accord du niveau de service en réagissant de manière proactive aux changements de qualité du service, p. ex. par reconfiguration après dégradation ou mise à niveau de la qualité du service
H04L 43/08 - Surveillance ou test en fonction de métriques spécifiques, p. ex. la qualité du service [QoS], la consommation d’énergie ou les paramètres environnementaux
11.
POTASSIUM CHANNEL ACTIVATORS AND THEIR USE IN TREATING DISORDERS INVOLVING HYPEREXCITABILITY
FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (Allemagne)
THE MAGNA GRAECIA UNIVERSITY OF CATANZARO (Italie)
UNIVERSITEIT ANTWERPEN (Belgique)
UNIVERSITY OF NAPLES FEDERICO II (Italie)
VIB VZW (Belgique)
Inventeur(s)
Gribbon, Phil
Keminer, Oliver
Leo, Antonio
Citraro, Rita
De Sarro, Giovanbattista
Weckhuysen, Sarah
Taglialatela, Maurizio
Miceli, Francesco
Carotenuto, Lidia
Abrégé
The invention is based on the repurposing of a clinically safe compound as a potassium channel activator for treating hyperexcitability related disorders. The invention also relates to a pharmaceutical composition comprising a compound of the present invention, as well as a method of treating hyperexcitability related disorders using the disclosed compounds or a pharmaceutical composition of the invention.
Provided herein is a method for obtaining electron diffraction, ED, data from a sample (100) using an electron microscope, EM, having an EM beam, the sample (100) containing a particle region (110) comprising one particle (112) or a cluster of multiple particles (112), the method comprising steps: receiving a two-dimensional intensity map, 2D intensity map (200), from the sample (100) using the EM, wherein the 2D intensity map (200) contains a region 2D intensity map (210) corresponding to the particle region (110); determining, from the region 2D intensity map (210), a region perimeter (310); determining from the region 2D intensity map (210) one or more beam target locations (420 a to d) corresponding to one or more locations (320 a to d), perimeter locations, only on the region perimeter (310); acquiring electron diffraction, ED, data from the particle region (110), using the EM; wherein during the acquiring of ED data from the particle region (110) the EM beam is activated only at the one or more beam target locations (420 a to d).
Provided here is a method for generating a reconstructed image (500) from electron diffraction data of a test sample (100), comprising: - receiving the electron diffraction data of the test sample (100) comprising a plurality of test event-detected counts (210a, 210b, 210c); - selecting, for each test event-detected count (210a, 210b, 210c), a kernel image (e.g. 310b, e, h) (selected kernel image (e.g. 310b, e, h)) from a kernel image library (300) comprising a plurality of kernel images (e.g. 310a to i); wherein each kernel image of the kernel image library (300) (e.g. 310a to i) is a pre-calculated mosaic for adding to a reconstruction grid (400) of the reconstructed image (500), wherein multiple selected added mosaics are capable of mosaicking and rendering the reconstructed image (500); and - generating the reconstructed image (500), comprising adding each selected kernel image (310b, 310e, 310h) to the reconstruction grid (400) thereby gradually mosaicking and rendering the reconstructed image (500).
The invention provides therapeutic agents which can be used in the treatment of neuropathy, myopathy or cardio(myo)pathy. More particularly, the invention provides compounds which are capable of stimulating autophagy, methods for identifying subjects susceptible to treatment with such compounds and methods for identifying such compounds.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
A61K 31/165 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide
A computer-implemented method for determining water content of a moist sample of porous material from a spectral reflectance spectrum of the moist sample is provided. The method includes obtaining (201) a hyperspectral measurement of the moist sample having the spectral reflectance spectrum (212), and a spectral response function (211) associated with the hyperspectral measurement; and determining (202) a water-layer thickness (215) within the moist sample based on the spectral response function, the spectral reflectance spectrum of the moist sample, a spectral reflectance spectrum of an air-dried sample of the porous material, and an absorption spectrum of water. The water content of the moist sample (221) is determined according to a first predetermined relationship (220) or a second predetermined relationship (230) based on (203) the water-layer thickness within the moist sample.
The present invention relates to the field of mucins and mRNA isoforms thereof, more in particular the use of mucins and mRNA isoforms in subjects suspected having an intestinal disorder. Provided herein is an in vitro method for determining the presence of barrier damage to the intestinal tract and/or prediction of therapy response and recovery thereto by determining the expression of at least 3 mRNA isoforms originating from genes selected from the list comprising: MUC1, MUC2, MUC3A, MUC4, MUC5AC, MUC5B, MUC6, MUC12, MUC12-AS1, MUC13, MUC16, MUC17, MUC19, MUC20 or an overlapping transcript or a pseudogene thereof.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
17.
CROSSLINKABLE LIQUID COMPOSITION FOR USE IN A METHOD OF MYOPIA MANAGEMENT IN A SUBJECT
The invention relates to a crosslinkable liquid composition comprising a gelatin or a gelatin-based crosslinkable biomaterial for use in a method of myopia management in a subject, such as for use in a method of one or more of preventing or reducing the progression of myopia or preventing an eye disease associated with myopia progression in a subject. In particular, the method may comprise: applying a crosslinkable liquid composition onto the anterior corneal surface of the eyes of the subject, wherein the method comprises introducing the crosslinkable liquid composition into a mold which is positioned onto the anterior corneal surface of the eyes; crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eyes, thereby obtaining a crosslinked composition on the anterior corneal surface of the eyes; and correcting the curvature of the crosslinked composition to create a peripheral myopic defocus.
Present application discloses a method for converting CO2 to CO, comprising: supplying CO2 to a gliding arc plasma reactor, said gliding arc plasma reactor comprising multiple parallel electrode pairings, and igniting a plasma in said gliding arc plasma reactor; operating said gliding arc plasma reactor at a pressure Po of at least 0.95 atm; and operating said gliding arc plasma reactor at a specific energy input SEI between 4.5 and 7.0 kJ / L CO2.
Example embodiments relate to a computer-implemented method for determining a slope (216) of a linear relationship between a crowd size (174) and a mean attenuation (175) of signals exchanged between transceivers (111 - 117) of a first crowd counting system based on parameters of a second crowd counting system; wherein respective positions of the transceivers of a crowd counting system define an environment (105) monitored by the crowd counting system. The computer-implemented method comprising: determining (201) a first mean overlapping distance (211) for the first crowd counting system, and a second mean overlapping distance (212) for the second crowd counting system; obtaining (202) a first path loss model (213) for the first crowd counting system, and a second path loss model (214) for the second crowd counting system; obtaining (203) a slope of the second crowd counting system as a reference slope (216); and determining (204) the slope (216) of the first crowd counting system as proportional to the reference slope (215), to a ratio (217) of the first mean overlapping distance to the second mean overlapping distance, and to a ratio (218) of the first path loss model to the second path loss model.
G01S 7/00 - Détails des systèmes correspondant aux groupes , ,
G01S 13/00 - Systèmes utilisant la réflexion ou la reradiation d'ondes radio, p. ex. systèmes radarSystèmes analogues utilisant la réflexion ou la reradiation d'ondes dont la nature ou la longueur d'onde sont sans importance ou non spécifiées
G01S 13/04 - Systèmes déterminant la présence d'une cible
G01S 13/87 - Combinaisons de plusieurs systèmes radar, p. ex. d'un radar primaire et d'un radar secondaire
In a method, for training an artificial neural network (ANN) to reduce noise and/or artefacts in an electron microscopy image, a plurality of training image pairs is generated. For each pair, an undistorted synthetic specimen image and a distorted image are created by simulating additional noise and/or artefact features. The ANN is trained, in which the distorted images are used as input and the corresponding undistorted images as output. An adversarial training strategy is used in which the ANN is trained, as a generator network, in conjunction with concomitantly training a further ANN, as a discriminator network, to differentiate output produced by the generator network from synthetic images in the training set. In training, parameters of the ANN and further ANN are optimized using a generator loss function and a discriminator loss function, in which a dependency exists between said loss functions to train the networks in an adversarial manner.
G06T 5/10 - Amélioration ou restauration d'image utilisant le filtrage dans le domaine non spatial
G06V 10/75 - Organisation de procédés de l’appariement, p. ex. comparaisons simultanées ou séquentielles des caractéristiques d’images ou de vidéosApproches-approximative-fine, p. ex. approches multi-échellesAppariement de motifs d’image ou de vidéoMesures de proximité dans les espaces de caractéristiques utilisant l’analyse de contexteSélection des dictionnaires
The present invention relates to medical devices, more precisely medical devices in the field of cannulation techniques. In particular, the invention concerns a device to guide a needle and to support the formation of a tunnel in a subject's skin, and methods to use such a device in a subject.
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
A61M 5/42 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour insensibiliser la peau, pour soulever la peau en vue de faciliter la piqûre ou pour localiser le point du corps où la piqûre doit être effectuée
The current invention relates to a compound of Formula (I) or a stereoisomer, tautomer, racemic, metabolite, prodrug, salt, hydrate, or solvate thereof, The invention also relates to a pharmaceutical composition comprising said compound. The invention also relates to said pharmaceutical composition or said compound for use as a medicine, for use in the prevention and/or treatment of diseases.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
The present invention in general relates to the field of cancer diagnosis and/or monitoring. More in particular, the current invention provides a multi-cancer diagnosis or detection method by determining the DNA methylation status in a sample from a subject suspected of cancer. In particular, the method of the present invention determines the methylation status of CpG dinucleotides across 3 or more selected CpG sites as disclosed herein.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
24.
ACTIVE LAYERS FOR SECOND-ORDER NONLINEAR OPTICAL APPLICATIONS
A second-order nonlinear optical device, includes (i) an active layer and (ii) an electric field generator. The active layer includes a matrix material, and second-order nonlinear optical chromophores dispersed in the matrix material. Each chromophore has a conjugated system having at least a first nitrogen atom connected to a second nitrogen atom via a conjugated path and a positive charge localized on one of the nitrogen atoms. The chromophore is switchable between a first state in which the positive charge is localized on the first nitrogen atom and a second state in which the positive charge is localized on the second nitrogen atom, and under thermal equilibrium both states are populated. The electric field generator is for switching at least some of the chromophores from the first state to the second state or from the second state to the first state, or to reorient at least some of the chromophores.
Disclosed is a method for manufacturing anti-caking fertilizer particles (100) comprising an inorganic fertilizer core (102) and a nanoparticle coating (104), wherein the nanoparticle coating (104) is free of binders.
Anti-caking fertilizer particles (100) comprising an inorganic fertilizer core (102) and a bio-based wax coating (106) are disclosed. The bio-based wax coating (106) comprises nanoparticles (104). The nanoparticles (104) do not extend beyond the surface of the bio-based wax coating (106).
The present invention is directed to the field of dementia, providing non-purified CSF and CSF- derived EVs markers for differential dementia diagnosis in patients with Alzheimer's, Parkinson's and Lewy body dementia. It not only provides the markers, but equally the method in using said markers for differential dementia diagnosis amongst the aforementioned patients.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
28.
METHODS AND SYSTEMS FOR DETERMINING RESPIRATORY HEALTH
The present application provides methods for determining a respiratory health of a test subject based on mass spectrometry data of a sample of exhaled breath of the test subject. Also provided are methods for assessing the efficacy of a therapeutic treatment of a respiratory disease in a test subject based on mass spectrometry data of one or more samples of exhaled breath of the test subject. Further provided are systems or devices for use in said methods and the use of said systems or devices.
The present disclosure relates to a device for gas conversion comprising a plasma reactor and a chamber configured for receiving a gas flow of converted and unconverted feed gas evacuated from the plasma reactor. The chamber comprises a supply throughput for filling the chamber with solid reactant material so as to form the fixed bed of solid reactant material, and at least one gas exhaust window for extracting a product gas. The device for gas conversion further comprises a silo for storing a stock of the solid reactant material and a connecting tube connecting a bottom opening of the silo with the supply throughput of the chamber. The silo and the connecting tube are configured such that, when the device is in operation and solid reactant material is being depleted in the chamber, a flow of solid reactant material from the silo to the chamber is induced so as to maintain the chamber filled with solid reactant material, and wherein the flow of solid reactant material from the silo to the chamber is induced by a gravitational force or at least partly by a gravitational force. The present disclosure also relates to a method for gas-conversion.
B01J 8/08 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules mobiles
B01J 8/00 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés
B01J 8/10 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules mobiles mues par des agitateurs ou par des tambours rotatifs ou par des récipients tournants
B01J 8/12 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules mobiles se déplaçant par gravité en un flux descendant
An intraocular lens, which contributes to the focusing of incident light onto a user's retina, includes a first and second surfaces. The first surface is configured to focus the incident light refractively. The first surface exhibits a non-uniform refractive power. The second surface is provided with a diffraction generating profile configured to spatially separate the incident light into at least a first portion with a first spatial frequency characteristic and a second with a second spatial frequency characteristic. The spatial separation and the non-uniform refractive power of the first surface cause the first portion to be refracted by the first surface at a first level of refractive power and the second portion to be refracted by the first surface at a second level of refractive power. The first level of refractive power and the second level of refractive power are different.
A feeding system for feeding a powder material to a moving powder mass includes a moving device structured to move the powder mass along a movement direction and a feeding reservoir that is structured to provide the powder material to be fed to the moving mass. The feeding reservoir includes a plurality of feeding openings dimensioned for feeding the powder material to the moving powder mass. At least some of the plurality of feeding openings being arranged along the movement direction of the moving powder mass.
B65D 88/66 - Grands réceptacles caractérisés par des moyens pour faciliter le remplissage ou le vidage en empêchant la formation de ponts par des dispositifs à vibration ou à chocs
The invention provides methods of increasing the reproductivity, growth rate and/or pigmentation of an aquatic animal, such as fish by feeding said aquatic animal with a feed composition comprising purple bacteria. The invention further provides feed compositions for use in such methods.
A23K 10/18 - Ajout de micro-organismes ou de leurs produits d’extraction, p. ex. de protéines provenant d’organismes unicellulaires, à des compositions de produits alimentaires de micro-organismes vivants
A23K 50/80 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les animaux aquatiques, p. ex. pour les poissons, les crustacés ou les mollusques
Provided herein is a device (100) for generating plasma using a flowing gas comprising: - a longitudinal electrode assembly (30) comprising: - a longitudinal electrically insulative body (38) having a proximal (10) and distal (20) end, - a proximal electrode (32) configured for contacting the gas, provided only at the distal end (20) of the insulative body (38), and disposed in fixed relation thereto; - a gas flow assembly (60) comprising: - a gas flow body (62); - a through-opening (64) in the gas flow body configured for receiving the longitudinal insulative body (38); - one or more gas inlets (66) in the gas flow body (62) for inlet of the gas; - one or more gas outlets (70) configured for outflow of the gas; - a helical flow guide (80) comprising one or more helical channels (88), each helical channel (88) having at least 0.5 helical turns, configured to direct the gas provided from the one or more gas inlets (66) along the one or more helical channels (88) to the one or more gas outlets (36), wherein: - the electrically insulative body (38) is mounted in the through-opening (64), and - the one or more helical channels (88) and the one or more gas outlets (36) are both disposed peripheral (P) of the through opening (64).
There is described an air treatment system (10) and method for filtering volatile organic compounds. The air processing circuit (100) comprises a filter module (200) configured to remove volatile organic compounds and a filter regeneration module (300). The air processing circuit (100) is configured to be selectively operatable in an air purification mode (130) and a filter regeneration mode (140).
The present invention relates to the field of organic synthesis, and in particular, the present invention pertains to a process for preparing a levulinic acid or salt thereof, or levulinate.
The invention relates to combinations of Alzheimer disease risk loci, more in particular short genetic variant loci (SGVs). Combinations of such SGVs were identified that are significantly and synergistically pathogenic. Applications of these combinations, such as diagnostic applications, are included as well.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
37.
TOOL FOR CONTINUOUS INSERTION-DEPTH MONITORING FOR IMPLANTABLE LEAD
A system for regulated insertion into a subject's heart of an implantable lead configured to transmit electrical signals, the system comprising: an adapter with distal end and proximal end comprising: an adapter distal connector, providing dismountable mechanical, electrical attachment to a proximal connector of the lead, configured to mechanically attach in fixed rotational relation to the connector; a rotational interface, comprising a rotational joint having a distal body rotationally attached to a proximal body, configured to conduct electrical signals across the rotational joint; an adapter proximal connector configured for dismountable mechanical, electrical connection to a pacing spectrum analyser; the adapter configured so electrical signals are transmittable between a distal helical electrode of the lead and the adapter proximal connector during rotations of or in the distal body, thus changing the depth of the inserted electrode; reducing or eliminating rotation of the adapter during rotations of or in the distal body.
The invention concerns a crosslinkable liquid composition for use in a method of curative or preventive treatment of an eye disorder in an eye of a subject, or for use in a surgical method of preparing a corneal onlay on or a corneal inlay in an eye of a subject, wherein the crosslinkable liquid composition comprises: a crosslinkable biomaterial, wherein the crosslinkable biomaterial comprises a gelatin functionalized with one or more tyrosine-derived or phenol groups; and a visible and/or UV light photoinitiator system.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
39.
CROSSLINKABLE LIQUID COMPOSITION FOR USE IN A METHOD OF TREATING AN EYE DISORDER
The invention relates to a crosslinkable liquid composition comprising: (i) a polyethylene glycol diacrylate (PEGDA), (ii) a gelatin or gelatin-based crosslinkable biomaterial, and (iii) a photoinitiator and optionally a co-initiator, for use in a method of treating an eye disorder in an eye of a subject, wherein the method comprises applying a crosslinkable liquid composition onto an anterior corneal surface of said eye comprising said eye disorder using a mold, crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eye, thereby obtaining a crosslinked composition on the anterior corneal surface of the eye, and correcting the curvature of the crosslinked composition.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
40.
HYPOXIA-RESISTANT IMMUNE CELLS FOR SUSTAINED PERSISTENCE AND FUNCTIONALITY IN THE HYPOXIC TUMOR MICROENVIRONMENT
The invention concerns a population of hypoxia-resistant immune cells, such as hypoxia-resistant T cells or Natural Killer (NK) cells for use as a medicament. The hypoxia-resistant immune cells are considered for use in treating different cancers such as haematological malignancies and solid tumours. The invention further concerns methods for producing said hypoxia-resistant immune cells and pharmaceutical compositions comprising said hypoxia-resistant immune cells.
Eberhard Karls Universität Tübingen Medizinische Fakultät (Allemagne)
Universiteit Antwerpen (Belgique)
Inventeur(s)
Schütz, Monika
Renschler, Fabian
Schweers, Jonas Malte
Autenrieth, Ingo
Poso, Antti
Kronenberger, Thales
Augustyns, Koen
Kurki, Milla
Cantini, Niccolo
Valembois, Sophie
Abrégé
The invention relates to a novel compound for the treatment and prophylaxis of a disease, especially a bacterial infectious disease, for reducing pathogen virulence and promoting host-induced clearance of infection and/or sensitizing bacteria to antibiotic treatment, a method for preparing said compound, a pharmaceutical composition comprising said compound, and to a method for the treatment and/or prophylaxis of a disease, preferably a bacterial infectious disease.
The present invention is in the field of synthetic organic chemistry and chemical recycling, and relates to a method for obtaining one or more C-C double bond addition products. The present invention is particularly useful in obtaining one or more value products from a pyrolysis crude obtained from waste plastics, such as polyolefin type waste, and allowing separation and valorization of complex mixtures comprising saturated and unsaturated hydrocarbons.
C07C 67/04 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques sur des liaisons carbone-carbone non saturées
C07C 67/54 - SéparationPurificationStabilisationEmploi d'additifs par modification de l'état physique, p. ex. par cristallisation par distillation
C07C 29/48 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par des réactions d'oxydation avec formation de groupes hydroxyle
C07C 29/128 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par alcoolyse
C07C 31/125 - Alcools monohydroxyliques acycliques contenant de cinq à vingt-deux atomes de carbone
C07C 69/24 - Esters d'acides acycliques monocarboxyliques saturés dont le groupe carboxyle est lié à un atome de carbone acyclique ou à l'hydrogène avec au moins trois atomes de carbone dans la partie acide estérifiés par des composés monohydroxylés
C07C 69/63 - Esters contenant des atomes d'halogène d'acides saturés
C07C 29/09 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par hydrolyse
C10G 1/10 - Production de mélanges liquides d'hydrocarbures à partir de schiste bitumineux, de sable pétrolifère ou de matières carbonées solides non fusibles ou similaires, p. ex. bois, charbon à partir de caoutchouc ou de déchets de caoutchouc
43.
METHOD FOR PRODUCING AN ORGANIC FUNCTIONALIZED INORGANIC SUBSTRATE
Methods are disclosed for producing an organic functionalized solid inorganic substrate, a surface of the inorganic substrate comprising a hydroxide and/or an oxide comprising an element M, the element M being a metal or a metalloid. The method includes drying the surface; optionally removing protons from the surface; and contacting the surface with an organometallic reagent comprising at least one organic functional moiety, thereby obtaining the organic functionalized inorganic substrate, the at least one organic functional moiety being attached to the element M of the hydroxide and/or the oxide by means of a direct M-C bond. The drying step includes contacting the surface with a flow comprising an inert gas. The organic functionalized inorganic substrate obtained by the method may be used as a membrane, a catalyst, a sorbent, a sensor or an electronic component, or as a substrate in filtration, adsorption, chromatography and/or separation processes.
C09C 3/00 - Traitement, en général, de substances inorganiques, autres que des charges fibreuses, pour améliorer leurs propriétés de pigmentation ou de charge
C09C 3/04 - Traitement physique, p. ex. broyage, traitement par des vibrations ultrasoniques
C09C 3/08 - Traitement par des composés organiques de bas poids moléculaire
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
25 - Vêtements; chaussures; chapellerie
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
43 - Services de restauration (alimentation); hébergement temporaire
Produits et services
Scientific apparatus and instruments; electric and
electronic apparatus and instruments for input, storage,
processing, transmission and display of data; computers;
word processing apparatus and instruments; sound and video
recordings; slides and cinematographic films, ready for
display; teaching apparatus and instruments; parts of the
aforementioned goods; computer software; compact discs;
phonograph records; audio and video tapes; audio and video
cassettes; DVDs; data cartridges; magnetic data carriers;
apparatus for recording, transmission and reproduction of
sound or images; data carriers; interactive computer discs
and compact discs (read-only memory); computer programs and
software, provided online; software applications; electronic
publications, downloadable or on data carriers, whether or
not provided online. Paper; cardboard; bookbinding material; photographs;
stationery; adhesives for stationery or household purposes;
artists' and drawing materials; paintbrushes; typewriters
and office requisites (except furniture); instructional and
teaching materials (except apparatus); plastic materials for
wrapping and packaging, not included in other classes;
printers' type; printing blocks; printed matter, including
books, printed courses, magazines, leaflets and posters. Clothing, footwear, headgear. Administrative management of data relating to
accommodations; business administration; business analysis;
business research; providing information and advice relating
to business management; assistance and consultancy in the
field of business organization and economic business
assistance and consultancy; public relations; business
management assistance relating to the implementation of
research centres; retail trade services in the field of
downloadable electronic publications, computer programs,
data carriers, printed matter, teaching apparatus, books,
leaflets, posters, journals, monthly magazines, writing
material, office requisites, notepads, teaching materials,
plastic materials for wrapping and packaging, printed
courses, magazines, leaflets, posters, clothing, footwear
and headgear; organization of expositions and trade shows
for commercial and advertising purposes; word processing;
administrative processing of data; human resource management
in the field to career-related issues. Education; training; entertainment services; sporting and
cultural activities; educational activities and events, also
by academies; organizing lectures, seminars, courses and
conferences with an educational character; audiovisual
production; publishing books, courses, magazines and
brochures, whether electronically or otherwise. Scientific and technological services, including related
research and design services; industrial analysis and
research services; design and development of computers and
software. Providing temporary facilities for conventions, conferences,
lectures, expositions, day school, workshops and seminars;
providing of temporary accommodation; restaurant and pub
services; catering services.
A model for describing a specific nasal cavity shape has a generic nasal cavity shape model including an average nasal cavity shape and a set of nasal cavity shape eigenmodes. The model includes a set of specific parameters such that the specific nasal cavity shape is modelled by a combination of the average nasal cavity shape and a linear combination of the set of specific parameters with the set of nasal cavity shape eigenmodes.
A method of predicting spectroscopic data pertaining to a chemical processes to be analyzed. The method includes obtaining a feature vector (114; 204) for a set of process variables (111; 211) pertaining to the chemical process, by applying the set of process variables as inputs to a learning structure (112), and generating spectroscopic data (113; 213) in respect of the chemical process, by applying the feature vector as input to a decoder unit (105). The decoder unit is derived from an autoencoder (107) that encodes spectroscopic measurements (102) into code vectors (104). The learning structure generates feature vectors (114; 204) that are predictions of the code vectors (104), provided that the spectroscopic measurement (102) correlates with and relates to the same chemical process as the set of process variables (111; 211).
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
G01N 30/00 - Recherche ou analyse de matériaux par séparation en constituants utilisant l'adsorption, l'absorption ou des phénomènes similaires ou utilisant l'échange d'ions, p. ex. la chromatographie
G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
The present invention relates to devices for maintaining a state of equilibrium, and process set-ups to perform equilibrium reactions using heterogeneous catalysts, in particular said reactions are equilibrium reactions where at least one reaction product is volatile. The invention is especially interesting for enzymatic reactions using immobilized enzymes, although it is also useful for pure chemical reactions. The invention is characterized by a combination of non-impact mixing of components and volatilization and/or removal of excess molecules, thereby maintaining a state of equilibrium or driving an equilibrium reaction. The present invention also relates to devices and/or process set-ups and materials made using said processes.
B01J 8/10 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules mobiles mues par des agitateurs ou par des tambours rotatifs ou par des récipients tournants
B01J 8/08 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules mobiles
C12M 1/40 - Appareillage spécialement destiné à l'utilisation d'enzymes libres, immobilisées ou liées à un support, p. ex. appareils contenant un lit fluidisé d'enzymes immobilisées
The present invention relates to the field of polyurethane recycling and pertains to a method of recycling of a polyurethane, comprising a first alcoholysis step and a further thermolysis step. By means of the method according to the present invention, it is possible to recover both the polyols and isocyanates from said polyurethane.
C08J 11/24 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance organique par traitement avec des composés organiques contenant de l'oxygène contenant des groupes hydroxyle
C07C 29/00 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons
C07C 263/04 - Préparation de dérivés d'acide isocyanique à partir de, ou en passant par des carbamates ou des halogénures de carbamoyle
C07C 269/02 - Préparation de dérivés d'acide carbamique, c.-à-d. de composés contenant l'un des groupes l'atome d'azote ne faisant pas partie de groupes nitro ou nitroso à partir d'isocyanates avec formation de groupes carbamate
49.
A PHASE-CONTRAST X-RAY IMAGING SYSTEM FOR OBTAINING A DARK-FIELD IMAGE AND A METHOD THEREFOR
A computer-implemented method for obtaining dark-field X-ray projection data of an object includes: obtaining a first set of X-ray projection data of the object at a first energy spectrum; the first set of X-ray projection data having a first attenuation component, a first phase component, and a first dark-field component; obtaining a second set of X-ray projection data of the object acquired at a second energy spectrum having a higher effective energy than the first energy spectrum; and extracting the dark-field projection data from the first set of X-ray projection data by the second set of X-ray projection data having a lower dark-field component contribution than the first set of X-ray projection data.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/40 - Agencements pour générer des radiations spécialement adaptés au diagnostic par radiations
50.
METHOD AND SYSTEM FOR OBTAINING A PLURALITY OF CAMERA IMAGES OF A TARGET POSE OVER TIME
A method and a system for obtaining a plurality of camera images of a target pose of at least part of a target body over time, wherein said target body is a living body performing a repetitive movement, the method comprising the steps of obtaining a plurality of images captured by a first camera of at least part of said target body; for each of said plurality of obtained images, verifying a presence of a predetermined pose of at least part of said target body, wherein said predetermined pose corresponds to a pose intervening in said repetitive movement at a time span ΔT before the target pose; when said predetermined pose is detected, triggering a second camera to capture at least one image of said target pose.
H04N 23/611 - Commande des caméras ou des modules de caméras en fonction des objets reconnus les objets reconnus comprenant des parties du corps humain
H04N 23/661 - Transmission des signaux de commande de la caméra par le biais de réseaux, p. ex. la commande via Internet
H04N 23/73 - Circuits de compensation de la variation de luminosité dans la scène en influençant le temps d'exposition
The present application relates to a method for processing a rubber composite material, particularly a rubber composite material comprising vulcanized rubber polymers and a filler material, wherein the method comprises the steps of contacting the rubber composite material with a suitable solvent, thereby obtaining solvent swollen rubber composite material; contacting the solvent swollen rubber composite material with ozone, thereby obtaining solubilized reaction products in the solvent and a solid residue; separating the solubilized reaction products from the solid residue; followed by working up the solubilized reaction products with a suitable chemical agent such as water or an organic base to obtain bifunctional oxygen-containing compounds, and, advantageously, recovering the filler material from the solid residue.
C08J 11/16 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance inorganique
C08J 11/14 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec de la vapeur ou de l'eau
C08J 11/18 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance organique
Provided is a method for determining an effect of a potential active agent on a sample comprising a co-culture comprising a target cellular object, TCO, and one or more further cell types, FCT, wherein the TCO has been labelled with a flourescent live-cell marker having a first emission/excitation profile, and with a luminescent cell-death marker, and optionally the FCT has been labelled with a fluorescent live-cell marker having a second emission/excitation profile different from the first emission/excitation profile, comprising capturing, during an acquisition event using a microscope, a first fluorescent image from the fluorescent live-cell marker having the first emission/excitation profile, and optionally a second fluorescent image from the fluorescent live-cell marker having the second emission/excitation profile, and a luminescence measurement of the sample, and comparing fluorescent images and luminescent measurements between sample contacted with the potential active agent and sample not contacted with the potential active agent, determining from a difference between test datasets and control datasets an effect of the potential active agent.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
The present invention relates to Metal Organic Frameworks (MOF), linkers for said MOFs and method of manufacturing thereof, wherein the MOF linker comprises a core and spacers having aryl moieties.
C07D 409/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
B01J 31/16 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination
54.
PLASMA REACTOR FOR PLASMA-BASED GAS CONVERSION COMPRISING AN EFFUSION NOZZLE
The present disclosure relates to a plasma reactor for plasma-based gas conversion comprising a plasma chamber and an effusion nozzle coupled to the plasma chamber. The plasma chamber comprises one or more gas inlets configured for introducing a feed gas into the plasma chamber, a first and a second electrode for generating gas discharge plasma, and at least one gas outlet opening for evacuating converted and unconverted feed gas from the plasma chamber. The effusion nozzle comprises a radial circumferential wall radially delimiting a gas-receiving cavity elongating along a central axis from a first end to a second end, and the gas-receiving cavity comprises an axial entrance opening at the first end for receiving the gas flow from the reaction chamber and an axial wall at the second end. The effusion nozzle is forming an extension of the second electrode or the effusion nozzle is forming the second electrode. The effusion nozzle further comprises one or more effusion openings for evacuating converted and unconverted feed gas from the gas-receiving cavity.
This invention discloses a particular photo-electrochemical method for the quantification of biological components involving type II photosensitizers and particles to enhance the photo-electrochemical signal.
A computer-implemented prediction method (100) for the control of industry-scale batch distillation processes and a distillation apparatus (400) controlled by this method are disclosed. The methods comprises building a hybrid model (103) by combining a phenomenological model of the batch distillation process with a first and a second statistical model. The phenomenological model includes an energy balancing constraint (301-2) that uses a liquid enthalpy coefficient (h) and a heat transfer coefficient (U) as inputs. The first and second statistical model predict dynamic changes of the liquid enthalpy coefficient and the heat transfer coefficient respectively. The hybrid model is trained with experimental data relating to at least one measurable process variable of the process and a performance indicator of the process is predicted based on the trained hybrid model. A control output relating to a control variable of the batch distillation process may be generated (107) if the predicted performance indicator (PPV) deviates from a measured value (MPV) of the performance indicator.
G05B 13/04 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques impliquant l'usage de modèles ou de simulateurs
G05B 17/02 - Systèmes impliquant l'usage de modèles ou de simulateurs desdits systèmes électriques
57.
RADIO FREQUENCY SYSTEM AND RELATED METHOD FOR COUNTING AND ACTIVITY RECOGNITION
A radio frequency system (1) for characterizing one or more groups of individuals (2) in a space (3), comprising: − a transmitter (101) transmitting two waveforms (11;12); − a receiver (102) configured to: o receive echoes (21;22) of the waveforms (11;12); o generate a range profile comprising a range distribution of the echoes (21;22); o generate filtered range profiles by filtering static clutter; − a processing unit (103) configured to: o range normalize the filtered range profiles; o generate an updated spatial map or an updated combined range profile after thresholding; o determine a total power between two distances in the updated spatial map or in the updated combined range profile; o generate therefrom one or more power metrics relating the total power to a density and/or an activity of the groups of individuals (2) in the space (3).
G01S 7/41 - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe utilisant l'analyse du signal d'écho pour la caractérisation de la cibleSignature de cibleSurface équivalente de cible
G01S 13/88 - Radar ou systèmes analogues, spécialement adaptés pour des applications spécifiques
58.
IGFBP2 AS BIOMARKER FOR THORACIC AORTIC ANEURYSM AND DISSECTIONS
The present invention provides methods for detecting thoracic aortic aneurysms and thoracic aortic dissections. In particular, the present invention provides an in vitro method for detecting a thoracic aortic aneurysm in a subject which relies on determining the level of Insulin-like Growth Factor Binding Protein-2 (IGFBP2) in a biological sample of the patient. The invention further provides a kit of parts for conducting the methods subject of the invention, and methods to monitor clinical progression of thoracic aortic aneurysm and assessing the efficacy of a therapeutic treatment directed against thoracic aortic aneurysm.
G01N 33/74 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des hormones
The present disclosure relates to an apparatus for generating a fluidized bed comprising solid particles mixed with a fluid. The apparatus comprises a fluidization compartment wherein a bottom side comprises a fluid distributor for distributing a fluid into the fluidization compartment and wherein an upper side comprises an opening. The apparatus further comprises a fluid supply compartment configured for supplying the fluid to be distributed by the fluid distributor, and a disengagement compartment comprising a bottom side having an opening matching or at least partly matching with the opening of the upper side of the fluidization compartment such that fluid can flow from the fluidization compartment to the disengagement compartment. The apparatus is characterized in that the fluidization compartment is rotatably mounted with respect to the fluidization compartment and with respect to the disengagement compartment such that the fluidization compartment is rotatable around a central axis while the fluid supply compartment and the
B01J 8/18 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés les particules étant fluidisées
B01J 8/00 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés
The present invention provides vaccines and compositions, methods and uses of immunogenic vaccine compositions for eliciting an immune response to members of trypanosomatids such as Trypanosoma brucei, T. cruzi and Leishmania species.
The present disclosure relates to the field of magnetic resonance imaging, specifically addressing a method for processing magnetic resonance image to identifying structural changes between magnetic resonance images acquired at different points of time. Additionally, the disclosure describes a system configured for the same. An aspect of the disclosure relates to a method comprising the steps of: acquiring a first image dataset through MRI scanning of the target volume at a first point in time; acquiring a second image dataset through MRI scanning of the target volume at a second point in time; reconstructing a magnitude image from the first image dataset, thereby obtaining a reference image; transforming the reference image to correspond with the second image dataset, thereby obtaining a transformed image comprising transformed image data, based on a set of deformation parameters; and optimizing a cost function configured to adjust the values of the set of deformation parameters until a stopping condition is satisfied, thereby obtaining a deformation vector field describing the structural changes in the target volume from the first time point to the second time point.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
25 - Vêtements; chaussures; chapellerie
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
43 - Services de restauration (alimentation); hébergement temporaire
Produits et services
Scientific apparatus and instruments, namely, microscopes; electric and electronic apparatus and instruments for input, storage, processing, transmission and display of data, namely, data input equipment being data processing equipment, data storage equipment blank tapes for storage of computer data, data processing equipment, data transmission equipment being wireless communication devices for data transmission, equipment for displaying data being LCD large-screen displays; word processing apparatus and instruments being word processing equipment; sound and video recordings featuring pre-recorded educational lectures, massive open online courses in the field of education, mini-documentaries; photographic slides and exposed cinematographic films, ready for display; teaching apparatus and instruments, namely, computers, overhead projectors; structural parts of the aforementioned goods; downloadable computer software for database management, medical diagnosis, learning and teaching being accessing and conducting online instructional courses, conducting and monitoring scientific research and data analysis, financial and HR Management, conducting and managing educational assessments and exams, conducting and managing quality assurance and accreditation reviews of educational assessments, and creating and managing virtual learning environments and simulations; downloadable software for creating and managing student information systems, for creating and managing library and information management systems, downloadable software tools for creating and managing student and faculty communication and collaboration platforms, and downloadable software tools for managing facility IT and infrastructure systems; compact discs featuring educational lectures, instructional videos and tutorial sessions, lab demonstrations and simulations, podcasts and interview series, research communication, training and onboarding, communication and promotional videos, event recording instructions, student presentations, all in the field of education, research, valorization and public service; audio and video tapes featuring educational lectures, instructional videos and tutorial sessions, lab demonstrations and simulations, podcasts and interview series, research communication, training and onboarding, communication and promotional videos, event recording instructions, student presentations, all in the field of education, research, valorization and public service; audio and video cassettes featuring educational lectures, instructional videos and tutorial sessions, lab demonstrations and simulations, podcasts and interview series, research communication, training and onboarding, communication and promotional videos, event recording instructions, student presentations, all in the field of education, research, valorization and public service; pre-recorded DVDs featuring educational lectures, instructional videos and tutorial sessions, lab demonstrations and simulations, podcasts and interview series, research communication, training and onboarding, communication and promotional videos, event recording instructions, student presentations, all in the field of education, research, valorization and public service; data cartridges featuring educational lectures, instructional videos and tutorial sessions, lab demonstrations and simulations, podcasts and interview series, research communication, training and onboarding, communication and promotional videos, event recording instructions, student presentations, all in the field of education, research, valorization and public service; magnetic data carriers featuring educational lectures, instructional videos and tutorial sessions, lab demonstrations and simulations, podcasts and interview series, research communication, training and onboarding, communication and promotional videos, event recording instructions, student presentations, all in the field of education, research, valorization and public service; apparatus for recording, transmission and reproduction of sound or images; data carriers featuring educational lectures, instructional videos and tutorial sessions, lab demonstrations and simulations, podcasts and interview series, research communication, training and onboarding, communication and promotional videos, event recording instructions, student presentations, all in the field of education, research, valorization and public service; interactive computer discs and read-only memory compact discs featuring educational lectures, instructional videos and tutorial sessions, lab demonstrations and simulations, podcasts and interview series, research communication, training and onboarding, communication and promotional videos, event recording instructions, student presentations, all in the field of education, research, valorization and public service; downloadable computer programs and software, provided online, for learning and teaching being accessing, conducting, and monitoring online courses of instruction, conducting and monitoring scientific research and data analysis, financial and HR Management, conducting, reviewing, and analyzing educational assessment and exams, conducting and managing quality assurance and accreditation reviews of educational assessments, creating and managing virtual learning environments and simulations; downloadable computer programs and software, provided online, being downloadable software for creating and managing student information systems, for creating and managing library and information management systems, downloadable software tools for creating and managing student and faculty communication and collaboration platforms, and downloadable software tools for managing facility IT and infrastructure systems; downloadable software applications for learning and teaching being accessing, conducting, and monitoring online courses of instruction, conducting and monitoring scientific research and data analysis, financial and HR Management, conducting, reviewing, and analyzing educational assessment and exams, conducting and managing quality assurance and accreditation reviews of educational assessments, creating and managing virtual learning environments and simulation; downloadable software applications being downloadable software for creating and managing student information systems, for creating and managing library and information management systems, downloadable software tools for creating and managing student and faculty communication and collaboration platforms, and downloadable software tools for managing facility IT and infrastructure systems; electronic publications, downloadable or recorded on data carriers, whether or not provided online, in the nature of books, newsletters, manuals, magazines, podcasts, newspapers, periodicals and videos, in the field of applied engineering, fine arts, business and economics, design sciences, law, medicine and health sciences, pharmaceutical-biomedical and veterinary sciences, science, social science, education, personal development, valorization Paper; cardboard; printed photographs; stationery; adhesives for stationery or household purposes; artists' and drawing materials, namely, drawing paper, canvas for painting, pencils, pens, markers, paint brushes, paint trays, erasers; typewriters and office requisites except furniture, namely, pens, ball-point pens; printed instructional and teaching materials in the field of applied engineering, fine arts, business and economics, design sciences, law, medicine and health sciences, pharmaceutical-biomedical and veterinary sciences, science, social science, education, personal development, valorization; plastic materials, namely, plastic sheets, for wrapping and packaging; printers' type; printing blocks; printed matter, namely, books, printed lessons, magazines, leaflets, posters, newspapers, and periodicals, all in the field of applied engineering, fine arts, business and economics, design sciences, law, medicine and health sciences, pharmaceutical-biomedical and veterinary sciences, science, social science, education, personal development, valorization Clothing, namely, hoodies, t-shirts, baby rompers, sports shirts, sports pants, slippers, fingerless gloves, fleece jackets, socks, scarfs; headwear Business administrative management of data relating to accommodations; business administration; business data analysis; business research; providing information and advice relating to business management; assistance and consultancy in the field of business organization and economic business assistance and consultancy; public relations; business management assistance relating to the implementation of research centres; retail store services featuring downloadable electronic publications, computer programs, data carriers, printed matter, teaching apparatus, books, leaflets, posters, journals, monthly magazines, writing material, office requisites, notepads, teaching materials, plastic materials for wrapping and packaging, printed courses, magazines, leaflets, posters, clothing, footwear and headwear; business administrative processing of data; human resource management in the field to career-related issues Educational services, namely, providing courses of instruction, classes, seminars, conferences, workshops, field trips in the field of applied engineering, fine arts, business and economics, design sciences, law, medicine and health sciences, pharmaceutical-biomedical and veterinary sciences, science, social science, education, personal development, valorization; training in the field of applied engineering, fine arts, business and economics, design sciences, law, medicine and health sciences, pharmaceutical-biomedical and veterinary sciences, science, social science, education, personal development, valorization; providing information relating to organizing community sporting and cultural activities; organization of sporting events in the field of student leisure; organizing and conducting college sport competitions; organizing cultural and international weeks for students; educational activities and events, also by academies, namely, educational activities and events, also by academies, namely, arranging exhibitions for entertainment purposes, academic and instructional activities, being lectures and seminars, workshops and skill trainings, laboratory sessions, field trips and site visits, final year projects, study groups and peer tutoring, all in the field of university and graduate education; educational activities and events, also by academies, namely, research-focused events, being research symposia and conferences in the field of education, science; educational activities and events, also by academies, namely, thesis or dissertation defences, research poster sessions, hackathons and innovation challenges, interdisciplinary research days, community and outreach events, being open days, campus tours, school partnership programs, all in the field of university and graduate education; educational activities and events, also by academies, namely, career fairs, networking fairs; alumni talks, student conferences, all in the field of university and graduate education; organizing lectures, seminars, courses and conferences with an educational character in the field of applied engineering, fine arts, business and economics, design sciences, law, medicine and health sciences, pharmaceutical-biomedical and veterinary sciences, science, social science, education, personal development, valorization; production of audiovisual film, documentaries and videos Scientific and technological services, including related research and design services, namely, scientific research services, scientific analysis services, technological research services, technological engineering analysis services, design and development of visualization technologies in the field of science, infographic design, prototyping and production design; scientific industrial analysis and research services in the field of applied engineering, fine arts, business and economics, design sciences, law, medicine and health sciences, pharmaceutical-biomedical and veterinary sciences, science, social science, education, personal development, valorization Providing temporary facilities for conventions, conferences, lectures, expositions, day school, workshops and seminars; providing of temporary accommodation; restaurant and pub services; catering services.
The invention provides a natural killer (NK) cell engineered to express a chimeric antigen receptor (CAR), wherein the CAR comprises the extracellular domain of CD27 or a CD70-binding portion thereof, as well as compositions comprising the engineered NK cell, methods for producing the engineered NK cell, and therapeutic applications of the engineered NK cell, such as for treating neoplastic diseases.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
25 - Vêtements; chaussures; chapellerie
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
43 - Services de restauration (alimentation); hébergement temporaire
Produits et services
Scientific apparatus and instruments; Electrical and electronic apparatus and instruments for the input, storage, processing, transmission and display of data; Computers; Word processing apparatus and instruments; Sound and video recordings; Photographic slides and cinematographic films, all prepared for exhibition; Teaching apparatus and instruments; Parts of the aforementioned goods; Computer software; Blank optical discs; Phonograph records; Audio tapes and Videotapes; Audio cassettes and Video cassettes; DVDs; Data cartridges; Magnetic data media; Apparatus for recording, transmission or reproduction of sound or images; Data storage media; Interactive compact discs and CD-ROMs; Computer programs and software, By online delivery; Application software; Electronic publications, downloadable or on data carriers, Including online. Paper; Cardboard; Bookbinding material; Photographs [printed]; Writing cases [stationery]; Gums [adhesives] for stationery or household purposes; Artists' materials; Brush pens; Typewriters and office requisites (except furniture); Teaching materials [except apparatus]; Plastic materials for packaging (not included in other classes); Printing type; Printing blocks; Printed matter, including the following products: Books, Courses, Magazines, brochures and Posters. Clothing, footwear, headgear. Administrative management of data, in the following fields: Gîtes; Business administration; Commercial analysis; Commercial research; Business management information and Advisory services for business management; Assistance and Consultancy in the following fields: Business economy and Business organization; Public relations services; Business organisation assistance, In the field of the implementation of research centres; Retail services in relation to the following goods: downloadable elctronic publications, Computer programs, Data carriers, Printed matter, Teaching apparatus, Books, manuals, Posters, Periodicals, Writing materials, Stationery items, Note pads, instructional materials, teaching material, Plastic materials for packaging, Seminars, Magazines, brochures, Posters, and clothing, footwear, and head gear; Organization of fairs andexhibitions for commercial and advertising purposes; Word processing; Administrative processing of data; Management of personnel, in the following fields: Issues relating to careers. Education; Training; Entertainment services; Sporting and cultural activities; Educational activities and events, including provided by academies; Arranging of lectures, seminars, courses and congresses of an educational nature; Recording and adaptation of sound or images; Electronic and non-electronic publishing In connection with the following goods: books, Courses, Magazines and brochures. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software. Providing of the following goods: Temporary premises for conventions, conferences, lectures, exhibitions, day schools, workshops and seminars; Providing of temporary accommodation; Restaurant services, Café services and Bar services; Food and drink catering.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
25 - Vêtements; chaussures; chapellerie
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
43 - Services de restauration (alimentation); hébergement temporaire
Produits et services
Scientific apparatus and instruments; Electrical and electronic apparatus and instruments for the input, storage, processing, transmission and display of data; Computers; Word processing apparatus and instruments; Sound and video recordings; Photographic slides and cinematographic films, all prepared for exhibition; Teaching apparatus and instruments; Parts of the aforementioned goods; Computer software; Blank optical discs; Phonograph records; Audio tapes and Videotapes; Audio cassettes and Video cassettes; DVDs; Data cartridges; Magnetic data media; Apparatus for recording, transmission or reproduction of sound or images; Data storage media; Interactive compact discs and CD-ROMs; Computer programs and software, By online delivery; Application software; Electronic publications, downloadable or on data carriers, Including online. Paper; Cardboard; Bookbinding material; Photographs [printed]; Writing cases [stationery]; Gums [adhesives] for stationery or household purposes; Artists' materials; Brush pens; Typewriters and office requisites (except furniture); Teaching materials [except apparatus]; Plastic materials for packaging (not included in other classes); Printing type; Printing blocks; Printed matter, including the following products: Books, Courses, Magazines, brochures and Posters. Clothing, footwear, headgear. Administrative management of data, in the following fields: Gîtes; Business administration; Commercial analysis; Commercial research; Business management information and Advisory services for business management; Assistance and Consultancy in the following fields: Business economy and Business organization; Public relations services; Business organisation assistance, In the field of the implementation of research centres; Retail services in relation to the following goods: downloadable elctronic publications, Computer programs, Data carriers, Printed matter, Teaching apparatus, Books, manuals, Posters, Periodicals, Writing materials, Stationery items, Note pads, instructional materials, teaching material, Plastic materials for packaging, Seminars, Magazines, brochures, Posters, and clothing, footwear, and head gear; Organization of fairs andexhibitions for commercial and advertising purposes; Word processing; Administrative processing of data; Management of personnel, in the following fields: Issues relating to careers. Education; Training; Entertainment services; Sporting and cultural activities; Educational activities and events, including provided by academies; Arranging of lectures, seminars, courses and congresses of an educational nature; Recording and adaptation of sound or images; Electronic and non-electronic publishing In connection with the following goods: books, Courses, Magazines and brochures. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software. Providing of the following goods: Temporary premises for conventions, conferences, lectures, exhibitions, day schools, workshops and seminars; Providing of temporary accommodation; Restaurant services, Café services and Bar services; Food and drink catering.
66.
SYSTEM AND METHOD FOR THE ELECTROCHEMICAL CONVERSION OF A GASEOUS COMPOUND
A system and method with improved water management for the electrochemical conversion of a gaseous compound, in particular CO2, in a zero-gap electrolyzer comprises the direct injection of a liquid, such as water, in the gaseous feed comprising the gaseous compound (CO2) and providing the gas/liquid mixture to the membrane electrode assembly of the zero-gap electrolyser via an interdigitated flow channel. This way, the gas and the liquid are forced through the porous electrode structures, thus ensuring that both the liquid and the gaseous compound (CO2) are in close contact with the electrode, resulting in an improved hydration of the electrode and an efficient conversion of the gaseous compound (CO2).
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
C25B 3/07 - Composés contenant au moins un atome d’oxygène
The present disclosure relates to the field of medical image processing and, more in particular, to a method for determining an anatomical fracture reconstruction based on one or more medical images of a broken bone, and a system configured for the same. According to an aspect the method comprises the steps of: receiving medical image data associated with the broken bone, identifying the plurality of bone fragments in the medical image data, generating a plurality of 3D surface models that virtually represent the bone fragments; registering a plurality of landmarks matching the surface models; generating a reconstructed model representing a reconstructed form of the broken bone by selecting at least two landmarks; generating a template model representing an optimal alignment of the surface models; repositioning the surface models to align at the selected landmarks set using the template model as reference; iteratively refining the reconstructed model by selecting different landmarks; changing the position of the surface models to align at the different landmarks; evaluating a quality measure that quantifies how changing the position affects the quality of the reconstructed model until a stopping condition is satisfied; and determining an anatomical reconstruction of the broken bone by comparing the position of the identified bone fragments in the medical image data with the position of the corresponding surface models in the reconstructed model.
G06T 19/20 - Édition d'images tridimensionnelles [3D], p. ex. modification de formes ou de couleurs, alignement d'objets ou positionnements de parties
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G06T 7/33 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur les caractéristiques
68.
SUBSTITUTED PHENOTHIAZINES AS FERROPTOSIS INHIBITORS
The present invention relates to a compound of formula (I) or a stereoisomer, or tautomer, wherein R1, R2, R3, and R4 have the same meaning as that defined in the claims and the description. The present invention also relates to the use of such compounds for the prevention and/or treatment of a disease associated with ferroptosis and/or oxytosis such as liver disease, chronic kidney disease, ocular surface diseases, wound healing, multiple organ dysfunction syndrome, neurological disease, acute renal failure, ischemia-reperfusion injury, sepsis, prevention of transplant rejection, and iron metabolism-related disease. The present invention also provides pharmaceutical compositions comprising such compounds, as well as the use of the compounds as a medicament.
C07D 279/18 - Thiazines-1, 4Thiazines-1, 4 hydrogénées condensés avec des carbocycles ou avec des systèmes carbocycliques condensés en [b, e] avec deux cycles à six chaînons
A61K 31/5415 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame condensés en ortho ou en péri avec des systèmes carbocycliques, p. ex. phénothiazine, chlorpromazine, piroxicam
69.
SYSTEM FOR GUIDING IMPLANTATION OF A LEAD OF AN IMPLANTABLE PULSE GENERATOR FOR TREATMENT OF A PELVIC FLOOR DYSFUNCTION AND/OR OF A PELVIC FLOOR-RELATED DISORDER
A system comprising a processor wherein the processor is configured to: - receive measured data of the subject comprising: - pelvic floor muscle electromyography, PFM-EMG data of the subject, wherein the PFM-EMG data comprises at least: - a) action potential, AP, growth data, comprising one or more measurements of the peak-to-peak action potential growth, AP growth, of the subject, wherein the AP growth is an indication of an increase in contraction force per unit of stimulation delivered by the pulse generator (160); - determine from the measured data, real time guidance information for guiding a position and/or orientation of an electrode portion (126) during implantation, set of operating parameters of the pulse generator.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61B 5/391 - Électromyographie [EMG] des organes génito-urinaires
A61B 5/395 - Détails de la stimulation, p. ex. stimulation d’un nerf pour provoquer une réponse EMG
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/296 - Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électromyographie [EMG]
A computer implemented method for training a learning model for traffic prediction at respective localities by means of a learning system includes a convolution engine and an encoder-decoder. The method involves constructing a graph representation of the localities based on a spatial relation between the respective localities; populating the constructed graph with traffic data characterizing the traffic in the respective localities at respective time periods; convolving, by the convolution engine, for a respective locality and for a respective time period, the traffic data in the respective locality with the traffic data in its neighboring localities, thereby obtaining relation-based traffic representation; processing, by the encoder-decoder, for a respective locality and for a respective time period, the relation-based traffic representation, thereby obtaining a gradient information; and updating, for a respective locality, the learning model with the obtained gradient information, thereby training the learning model.
G06N 3/0442 - Réseaux récurrents, p. ex. réseaux de Hopfield caractérisés par la présence de mémoire ou de portes, p. ex. mémoire longue à court terme [LSTM] ou unités récurrentes à porte [GRU]
G08G 1/01 - Détection du mouvement du trafic pour le comptage ou la commande
The present disclosure relates to a sample support device for charged particle microscopy and related methods. The device comprises a substrate and a heating and/or biasing element integrated in or on the substrate to heat (or apply a bias voltage to) a sample when positioned in an observation region of the device. The device comprises a membrane covering an opening in the heater element and/or substrate in the observation region of the device. The membrane is perforated to form at least one hole covered by a graphene layer to form a sample support to place a sample of interest thereon for study. A cap covers the membrane such that a chamber is formed in which the sample can be isolated in a controllable gaseous environment.
The application discloses methods of ensuring pelvic health and/or treating a disease or disorder characterized by a dysfunctional autonomous nervous system in a subject with neuromodulation. The methods are characterized by the application of a burst stimulation pattern comprising a plurality of groups of electric pulses of high frequencies to the subject.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
73.
METHOD AND SYSTEM FOR PROCESSING A PLURALITY OF CAMERA IMAGES OF A HUMAN BODY TARGET AREA OVER TIME
A method and a system for processing a plurality of camera images of a human body surface target area over time, the method comprising the steps of obtaining a plurality of images of a human body surface target area of a human body captured by a first camera over time; obtaining physical data of said human body; and generating a 3D model of at least said human body surface target area.
The present invention relates to the field of combination immunotherapy, more in particular to a combination comprising ILL-15 and a CD40 agonist for use in the treatment of cancer, such as and not limited to, melanoma skin cancer (e.g.: superficial spreading melanoma, nodular melanoma, acral-lentiginous melanoma, lentigo maligna melanoma, amelanotic and desmoplastic melanomas, ocular melanoma, and metastatic melanoma).
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
The invention relates to methods for modifying T regulatory cells by introducing RNApolynucleotides thereto by electroporation, and further pertains to the modified Treg cells and their compositions and uses.
The present invention relates generally to an ammonia capture system or method comprising plasma NOx and, more particularly to such system and method for ammonia capture comprising a two-tank NOx absorption system. Furthermore the present invention concerns a system to produce ammonium nitrate in solution or as a solid from atmospheric ammonium.
The present invention relates to the field of combination immunotherapy, more in particular to a combination comprising IL-15 and a CD40 agonist for use in the treatment of cancer, such as and not limited to mesothelioma (e.g. pleural, peritoneal, pericardial or testicular mesothelioma).
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
The present invention to the identification of a novel isolated bacterial strain, the Limosilactobacillus reuteri strain which is characterized by a naturally occurring overproduction of riboflavin (vitamin B2) compared to other known strains of lactobacilli. Said strain of the Limosilactobacillus species is deposited under accession number LMG P-32020. In a further aspect, also the uses of said L. reuteri strain are disclosed herein. In particular, the use of said strain in food and feed industry, human and veterinary health, large-scale vitamin production, cosmetics and consumer care products is disclosed.
C12P 25/00 - Préparation de composés contenant des noyaux alloxazine ou iso-alloxazine, p. ex. riboflavine
C12N 9/78 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5)
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
The present invention relates to a compound of formula (I) or a stereoisomer, or tautomer, for use in the prevention or treatment of a disease associated with the activation of receptor tyrosine-protein kinase (erbB4). In formula (I), wherein n, A1, A2, A3, A4, A5, R1, R2, R3, and R4 have the same meaning as that defined in the claims and the description. The present invention also relates uses of such compounds for the prevention and/or treatment of a disease associated with the activation of receptor tyrosine-protein kinase (erbB-4) such as heart failure, metabolic disorders, inflammatory disorders, fibrotic disorders, and cancer. The present invention also provides pharmaceutical compositions comprising such compounds, as well as the use of the compounds as a medicament.
The present invention relates to a compound of formula (I) or a stereoisomer, or tautomer, for use in the prevention or treatment of a disease associated with the activation of receptor tyrosine-protein kinase (erbB4). In formula (I), wherein n, A1, A2, A3, A4, A5, R1, R2, R3, and R4 have the same meaning as that defined in the claims and the description. The present invention also relates uses of such compounds for the prevention and/or treatment of a disease associated with the activation of receptor tyrosine-protein kinase (erbB-4) such as heart failure, metabolic disorders, inflammatory disorders, fibrotic disorders, and cancer. The present invention also provides pharmaceutical compositions comprising such compounds, as well as the use of the compounds as a medicament.
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
Provided is a method for determining a status of a sample comprising a co-culture comprising a target cellular object, TCO (520), and one or more stroma-forming cell types, SCT (510, a to b), wherein: the TCO (520) has been labelled with a fluorescent live-cell marker having a first emission/excitation profile, and the SCT (510, a to b) has been labelled with a fluorescent live-cell marker having a second emission/excitation profile different from the first emission/excitation profile, the method comprising the steps: capturing, during an acquisition event using a microscope, a dataset comprising: a first fluorescent image from the fluorescent live-cell marker having the first emission/excitation profile, and a second fluorescent image from the fluorescent live-cell marker having the second emission/excitation profile, and wherein: at least one dataset is captured, for each dataset, a stroma (512) is identified for the TCO (520), wherein: a stroma (512) comprises at least one cluster (514, a to d); a cluster (514, a to d) comprises a plurality of cells of the SCT (510, a to b), and each SCT (510, a to b) cell in the cluster (514, a to d) directly contacts the TCO (520) or indirectly contacts the TCO (520) via one or more other SCTs (510, a to b) cells, wherein the status of the sample is determined from at least one parameter of the stroma (512).
Provided herein are compositions for topical use comprising an imidazole or a salt thereof, and domiphen bromide as active ingredients for use in treating or preventing a fungal infection, wherein said imidazole is chosen from ketoconazole and clotrimazole as active ingredients for use in treating or preventing a fungal infection.
The present disclosure relates to a vortex chamber comprising a cavity elongating along a central axis and a swirl generator. The swirl generator comprises a plurality of swirl channels configured for introducing a gas flow into the cavity as a vortex flow about the central axis, each swirl channel comprising a channel entrance and a channel exit. The swirl generator further comprises a gas redistribution chamber comprising one or more main gas supply inlets for receiving a gas, a distribution channel configured for distributing the gas received from the one or more main gas supply inlets to the channel entrances of the swirl channels, and one or more blocking walls configured for blocking and unblocking one or more entrances of the plurality of swirl channels. The vortex chamber is further configured for relatively rotating the channel entrances of the swirl channels with respect to the one or more blocking walls from a first angular position to at least a second angular position and vice versa, and wherein when in the second angular position the one or more blocking walls block a larger number of channel entrances than when in the first angular position.
The present invention is directed to a novel isolated bacterial strain of the Streptococcus salivahus (S. salivahus) species. More in particular, a strain of the S. salivahus species deposited at BCCM under accession number LMG P-31813. Further, the present invention relates to a composition comprising an isolated bacterial strain of the S. salivahus species. In another aspect, the present invention further relates to the isolated bacterial strain according to the present invention or the composition according to the present invention for use in immunomodulation and/or in the treatment and/or prevention of infections of diseases.
C07K 14/315 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Streptococcus (G), p. ex. Enterocoques
C022 0C00202, supplying the atomic oxygen into the mixing area at a first supply rate and supplying the carbon dioxide into the mixing area at a second supply rate, defining the first supply rate and the second supply rate such that a ratio between the first supply rate and the second supply rate remains within a pre-defined lower and upper threshold, and extracting carbon monoxide from the mixing area. The present disclosure also relates to an apparatus for converting carbon dioxide into carbon monoxide.
The present invention provides methods for detecting multiple biomarkers indicative for lysosomal storage diseases from a dried blood spot. In particular, the present invention provides a method that is suited for detecting multiple biomarkers, each indicative for the presence of a distinct lysosomal storage disease in a subject, based on a single sample preparation procedure. In particular, the method allows simultaneous extraction of different biomarkers such as Lyso-Gb1 (GlcSph), Lyso-Gb3, and others from a dried blood spot sample. The invention further provides a kit of parts comprising means for conducting the methods subject of the invention. Finally, the invention provides a set of reference ranges for Lyso-Gb1 (GlcSph) and Lyso-Gb3 in healthy subjects starting from dried blot spot samples.
G01N 33/92 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des lipides, p. ex. le cholestérol
The present application relates to a membraneless electrolysis reactor comprising a flow channel reactor having an inlet and an outlet; a first electrode and a second electrode; a first and a second distal flow channel which are directly connected to the outlet of the flow channel reactor, and an elongated divider or mesh comprising a plurality of openings located in the flow channel reactor between the first and second electrode. The present application further relates to a method of electrochemically producing at least one product, in particular a gaseous product, comprising (i) providing a membraneless electrolysis reactor according to the present application, (ii) flowing a stream of a liquid, particularly an electrolyte or a liquid comprising a reactant, through the flow channel reactor of the membraneless electrolysis reactor, under laminar flow conditions, in contact with the first and the second electrodes, (iii) generating an oxidation reaction product at the first electrode and a reduction reaction product at the second electrode, wherein the perforated divider or mesh and the laminar flow confine the oxidation reaction product and the reduction reaction product to opposing sides of the flow channel reactor.
The current invention relates to a compound of Formula (I) or a stereoisomer, tautomer, racemic, metabolite, prodrug, salt, hydrate, or solvate thereof, The invention also relates to a pharmaceutical composition comprising said compound. The invention also relates to said pharmaceutical composition or said compound for use as a medicine, for use in the prevention and/or treatment of diseases.
The invention provides methods of treating an eye disorder and compositions for use therein, the methods comprising applying a crosslinkable liquid composition onto an anterior corneal surface of said eye using a mold; crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eye, thereby obtaining a crosslinked composition on the anterior corneal surface of the eye; and correcting the curvature of the crosslinked composition.
The invention relates to new compounds of the general Formula (I), which are Dipeptidyl peptidase 9 (DPP9) enzyme inhibitors. The present invention further relates to specific compounds based on Formula (I) that binds to an E3 ligase and to DPP9 and induce proteolysis of DPP9. The invention also relates to specific DPP9 binding compounds comprising a probe moiety, according to formula (I). The present invention further relates to pharmaceutical compositions and their use thereof.
C07D 401/08 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
The present disclosure relates to a plasma reactor for plasma-based gas conversion comprising a pin electrode extending along a longitudinal axis from a first end to a second end, an opposing electrode opposing a discharge tip of the 10 pin electrode, a plasma chamber for confining a glow discharge plasma, and an electrically-insulating body that comprises an inner bore extending along the longitudinal axis from a bore entrance to a bore exit. The second end of the pin electrode comprises a discharge tip. The pin electrode penetrates the inner bore from the bore entrance and extends at least partly through the inner bore and a15 radial wall of a portion of the inner bore located between the second end of the pin electrode and the opposing electrode, is radially delimiting the plasma chamber. The plasma reactor is further configured for varying an electrode separation distance between the discharge tip of the pin electrode and the opposing electrode.
The present invention relates to a process for preparing a polycarbonate using metal-catalyzed cross- coupling, including the reaction of an iodinated diaryl carbonate with a structure of formula (I) and a terminal alkyne with a structure of formula (IIa) or a terminal alkene with a structure of formula (IIb). Furthermore, the invention relates to a polycarbonate comprising a repeating unit with a structure of formula (IIIa) or (IIIb).
Mucins and isoforms thereof are provided herein for use in the diagnosis, monitoring, prevention, and/or treatment of a disease characterized by barrier dysfunction, such as, but not limited to a gastrointestinal disorder (e.g. Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), cancer, gastrointestinal infections, obesitas, non-alcoholic fatty liver disease (NAFLD)), neurodegenerative disorders, respiratory infections, and more in particular coronaviral infections. In a specific embodiment, said mucins and/or isoforms thereof are selected from the list comprising: MUC16, MUC21, MUC20, MUC2, MUC4, MUC5AC, MUC5B, MUC13, and MUC1, and isoforms thereof.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
94.
CONTINUOUS FLOW REACTION DEVICE FOR AN ELECTROCHEMICAL PROCESS
A continuous flow reaction device (100) for an electrochemical process comprising: a reaction space (110), a pumping system (200) configured to generate a pulsatile flow, a plurality of discrete protrusions (120,a: 120,b) each configured such that a flow path (150a-150c) of the fluid contacting an inlet end (14) side of the discrete protrusion is split at least into two daughter flow paths (150b1; 150b2) on the outlet end (16) side of the discrete protrusion (120,a: 120,b); and the discrete protrusions (120,a: 120,b) being arranged so that at least one of the daughter flow paths (150b1) generated by one of the plurality of discrete protrusions (120) combines (152a) with at least one of the daughter flow paths (150a2) generated by another of the plurality of discrete protrusions (120) on the outlet end (16) side of both discrete protrusions (120) and wherein each (and every) discrete protrusion (120) is an electrode in the electrochemical process.
An in-air sonar system is provided for determining location and velocity information of objects in an environment. The in-air sonar system includes at least two emitters configured to emit respective sound signals into the environment; at least two receivers configured to receive sound signals from the environment; and a processing unit configured to perform: obtaining, from the receivers, respective received sound signals comprising the emitted sound signal reflected from objects in the environment; calculating, from the respective received sound signals, respective velocity-dependent range maps; deriving, from the calculated velocity-dependent range maps and the spatial diversity of the receivers, a velocity-dependent range-direction map comprising range information as a function of a received direction; determining therefrom a location of the respective objects; and extracting, from the velocity-dependent range maps and the spatial diversity of the receivers, a velocity of the respective objects based on the determined location.
A regenerable gas filter includes a housing having in-line an entrance and an exit, a pleated activated carbon fibre sheet or tube, with electrical conductors in the tip of each pleat and further electrical conductors being optionally attached to the ends of said sheet. The conductors are disposed substantially perpendicularly to the gas flow through the housing and the conductors on one side of the pleated sheet are connected to a single central conductor, which in turn was coupled to an electrical DC power source, which is repeated for the conductors on the other side of the pleated sheet. The sheet is stretched over and in electrical contact with the conductors and the pleated sheet or tube is provided with a sealing means to the housing. The regenerable gas filter is used for the purification of air in a Heating, Ventilation and Air Conditioning (HVAC) system.
B01D 53/04 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p. ex. chromatographie préparatoire en phase gazeuse avec adsorbants fixes
B01J 20/20 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone libreCompositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone obtenu par des procédés de carbonisation
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
The present invention relates to a method (1) of transferring a graphene layer onto a target substrate or support structure. The method comprises obtaining (2) a metal foil (12) onto which the graphene layer (11) is provided, stabilizing the graphene layer (11) by applying (4) a layer (13) of a cellulose-based polymer onto the graphene layer (11), and placing (5) the metal foil (12) with the graphene and the polymer layers in or on an etching solution (25) to dissolve the metal foil (12) supporting the graphene layer (11). The method comprises diluting and/or neutralizing (6) the etching solution (25) after the metal foil (12) has been dissolved, and depositing (7) the graphene layer (11) onto the target (20) by placing (27) the target underneath the graphene layer and removing (28) the diluted and/or neutralized solution until the graphene layer settles onto the target. The method comprises a dry cleaning (10) of the target to remove the polymer layer (13) by embedding the target in activated carbon (31) and heating.
A method for determining a three-dimensional atomic distribution of a sample having a tip, during an atom probe tomography process. The method accounts for the tip not being axial symmetric and not having a hemispherical shaped apex throughout the evaporation process.
H01J 37/26 - Microscopes électroniques ou ioniquesTubes à diffraction d'électrons ou d'ions
G01N 23/046 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux en utilisant la tomographie, p. ex. la tomographie informatisée
99.
COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR DETERMINING A DEGREE OF RESPIRATORY AIRFLOW
A computer-implemented method for determining a degree of respiratory airflow, the method comprising the steps of obtaining lung sound data over time including inspiration breathing sounds and expiration breathing sounds of at least one breathing cycle, the at least one breathing cycle including an inspiration phase and an expiration phase; pre-processing said lung sound data obtaining denoised lung sound data.
