Abrégé

A nuclear magnetic resonance tube (100) is disclosed, sized for fitting within an NMR machine (101). It comprises a semi-permeable membrane (105) located within the NMR tube (100) for providing a semi-permeable boundary between first a sample region (103) within the NMR tube (100) and a second sample region (104) within the NMR tube (100). The first sample region (103) is configured for holding a first sample. The second sample region (104) is configured for holding a second sample.

Classes IPC  ?

• G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
• G01R 33/30 - Dispositions pour le traitement des échantillons, p. ex. cellules d'essai, mécanismes rotationnels

Abrégé

A biological assay apparatus (2) for analysing motile biological structures is provided. The biological assay apparatus comprises an input region (12) for receiving a sample of motile biological structures and an assessment structure (6) defining a pathway (14) extending from the input region and along which the sample of motile biological structures can move. The assessment structure comprises one or more obstacles (10) which extend at least partially perpendicular to the pathway and which at least partially define the pathway.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

An apparatus for volumetric imaging is provided. The apparatus comprises an illumination assembly arranged to direct light to illuminate a plurality of planes in a sample region sequentially at an illumination rate, each plane extending over a plurality of depths in the sample region; an image sensor comprising a plurality of sections of pixels and arranged to sense each section of pixels sequentially at a sensing rate; and a light-receiving assembly arranged to receive light from the sample region and to direct light received from each of said planes in the sample region to a different respective section of said sections of pixels. The light-receiving assembly comprises a multi-plane optical assembly arranged to receive light from the plurality of depths in the sample region and, for each section of said sections of pixels, to direct light simultaneously from each of the plurality of depths in the respective plane to a different respective subsection of said section. The illumination rate is equal to the sensing rate, such that each section of pixels is arranged to sense light from the plurality of depths in the respective plane as the plane is illuminated by the illumination assembly.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné

Abrégé

An optical reference target (2) is provided. The target comprises a reference structure (6) provided by a polymer fibre. Polymer fibres can be created with predictable, controllable and uniform diameters, widths and/or thicknesses at a micro-scale or nano-scale at relatively low cost. Polymer fibres can also be manufactured to have other predictable, controllable and uniform properties such as refractive index (RI). The optical reference target can thus provide a reliable calibration and/or characterisation tool at very small scales and for a wide variety of optical imaging systems.

Classes IPC  ?

• G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope
• D01D 5/00 - Formation des filaments, fils ou similaires
• G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique

Abrégé

A system (2) for concentrating a substance dispersed in a fluid is provided. The system comprises a nanofluidic structure (14). The nanofluidic structure (14) comprises at least one dead-end nanochannel (18) extending in an extension direction from an entrance (22) to a dead-end (24). The dead-end nanochannel has a length in the extension direction and a width perpendicular to the extension direction, the length being greater than the width. The system further comprises an electrical apparatus (5) arranged to apply an electric field over the nanofluidic structure which is at least partially aligned with the extension direction of the dead-end nanochannel, to encourage a concentration of the substance to increase at the entrance and/or the dead-end of the dead-end nanochannel.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• G01N 1/40 - Concentration des échantillons
• G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux

Abrégé

A system (2) for analysing a sample comprising a motile cell (900) comprising at least a head portion (902). The system comprises an input interface (24) arranged to receive image data comprising a time series (100) of images (102, 104, 106) of the sample. The system further comprises a processing apparatus (16) arranged to determine one or more morphological parameters of the cell and to determine a motion trace of the head portion of the cell. The processing apparatus is arranged to use the one or more morphological parameters of the cell and the motion trace of the head portion of the cell to determine a quality metric for the cell.

Classes IPC  ?

• G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
• G06T 3/4046 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement utilisant des réseaux neuronaux
• G06T 3/4053 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement basé sur la super-résolution, c.-à-d. où la résolution de l’image obtenue est plus élevée que la résolution du capteur
• G06T 3/4069 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement basé sur la super-résolution, c.-à-d. où la résolution de l’image obtenue est plus élevée que la résolution du capteur par déplacements sous-pixelliques
• G06T 7/00 - Analyse d'image
• G06T 7/246 - Analyse du mouvement utilisant des procédés basés sur les caractéristiques, p. ex. le suivi des coins ou des segments
• G06V 10/20 - Prétraitement de l’image
• G06V 10/26 - Segmentation de formes dans le champ d’imageDécoupage ou fusion d’éléments d’image visant à établir la région de motif, p. ex. techniques de regroupementDétection d’occlusion
• G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
• G06V 10/62 - Extraction de caractéristiques d’images ou de vidéos relative à une dimension temporelle, p. ex. extraction de caractéristiques axées sur le tempsSuivi de modèle
• G06V 10/80 - Fusion, c.-à-d. combinaison des données de diverses sources au niveau du capteur, du prétraitement, de l’extraction des caractéristiques ou de la classification
• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires

Abrégé

The present invention relates generally to human medicine, and more specifically microRNA (miR)-replacement therapy for management of Venous Thromboembolism (VTE). In particular, the present invention provides pharmaceutical compositions comprising a miR mimic and a pharmaceutically acceptable carrier. The pharmaceutical compositions disclosed herein may be administered systemically, in particular by intravenous administration (IV).

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice

Abrégé

Computer software, a computer system (212) and a corresponding method for assessing health of a heart valve of a heart of a subject (202) are disclosed. A plurality of murmur-grade values are received, wherein each murmur-grade value is associated with a different respective auscultation position (102, 104, 106, 108). The plurality of murmur-grade values are input to a first trained software model (304), implemented by the computer software. The first trained software model (304) is operated to generate a value indicative of health of the heart valve. The value indicative of health of the heart valve is output from the first trained software model (304).

Classes IPC  ?

• A61B 7/04 - Stéthoscopes électriques
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

An optical component (6) comprises a substrate (10), an input (12) arranged to receive light, an output (14) arranged to output light and a waveguide arrangement (16) arranged to direct light from the input to the output. The waveguide arrangement comprises a membrane (18) extending over a channel (22) in the substrate to form an unsupported portion (20) that is separated from the substrate. The unsupported portion comprises an uninterrupted core section (24) extending between first and second surfaces of the membrane and a structured section (26) adjacent the core section comprising a plurality of holes (28) in said membrane. The core and structured sections form a waveguide arranged to direct light at least partway from the input to the output.

Classes IPC  ?

• G01N 21/3504 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse des gaz, p. ex. analyse de mélanges de gaz
• G01N 21/552 - Réflexion totale atténuée
• G02B 6/122 - Éléments optiques de base, p. ex. voies de guidage de la lumière

Abrégé

A method, apparatus and computer software for determining rate estimates from sounds emanating from a heart or respiratory system of a human or animal body. A plurality of sound recordings of a heart or respiratory system of a human or animal body are received, wherein each sound recording is or has been captured by a microphone positioned at a respective location on the exterior of the human or animal body. For each of the sound recordings, a respective individual rate is determined (51) by analysing a respective autocorrelation function of the sound recording and determining a respective quality measure. An aggregate rate estimate for the heart or respiratory system is determined (53) by evaluating a weighted combination of two or more of the plurality of individual rate estimates, wherein each of the individual rate estimates included in the weighted combination is weighted at least in part by the respective quality measure for the respective sound recording.

Classes IPC  ?

• A61B 7/00 - Instruments d'auscultation
• A61B 7/04 - Stéthoscopes électriques
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
• A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire

Abrégé

A computer-implemented method of processing image data to produce an output image is provided. The method comprises receiving image data comprising a stack of images (300), captured at different times, of part or all of a sample region (104) containing a sample (103); selecting from the stack of images a plurality of windows (wi), each window comprising a respective stack of spatially-coincident sections of the images. Each window is processed to determine indicator values (f) for test points representative of a likelihood of a part of said sample being present at a location of the sample region corresponding to the test point. The indicator values are combined to produce an output image (800) of the part or all of the sample region. At least one decomposing, calculating or determining step in the processing of the windows is carried out for a first window of the plurality of windows at the same time as at least one decomposing, calculating or determining step is carried out for a second window of the plurality of windows.

Classes IPC  ?

• G06T 5/50 - Amélioration ou restauration d'image utilisant plusieurs images, p. ex. moyenne ou soustraction
• G06T 1/20 - Architectures de processeursConfiguration de processeurs p. ex. configuration en pipeline

Abrégé

The present invention relates to enzymes having DNA polymerase and 3′-5′ exonuclease activities. In particular, the present invention relates to a heat labile enzyme possessing a DNA polymerase II activity and a 3′-5′ exonuclease activity of marine origin. Furthermore, the present invention relates to a DNA polymerase primarily exerting a 3′-5′ activity, i.e. where the polymerase activity is absent. The present invention furthermore relates to the use of the exonuclease activity to degrade the 3′-5′ strand of double stranded DNA to perform single stranded overhang, e.g. in recombinant cloning processes, or in processes for removal of contaminating nucleic acid molecules.

Classes IPC  ?

• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12N 9/16 - Hydrolases (3.) agissant sur les liaisons esters (3.1)

Abrégé

The present invention relates to DNA polymerases. In particular, the present invention relates to heat labile DNA polymerases of marine origin, having high polymerase activity, strand displacement activity and 3-5′ exonuclease activity. Furthermore, the present invention provides heat labile DNA polymerases substantially without strand-displacement activity.

Classes IPC  ?

• C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase

Abrégé

The present invention relates to recombinant DNA technology, in particular to methods for assembling two or more double stranded (ds) nucleic acid molecules with overlapping terminal sequences. In particular, the present invention relates to the use of a thermolabile DNA polymerase II derived 3′-5′ exonuclease isolated from Moritella viscoa and a thermolabile DNA polymerase I of marine origin in multi DNA assembly processes.

Classes IPC  ?

• C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)

Abrégé

The present invention relates to a method of determining whether a patient in remission from ulcerative colitis (UC) is in stable remission, said method comprising quantifying the level of gene expression of IFNG and IL33 in a gastrointestinal (Gl) mucosal sample from said patient and comparing said expression levels; in particular wherein a high level of expression of IL33 relative to IFNG is prognostic of stable remission and a level of expression of IL33 relative to IFNG which is not high, is prognostic of relapse.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The present invention relates to the use of a single-strand DNA binding protein (SSB) which exhibits at least 50% of its maximum ssDNA binding capability in the presence of 500 mM of sodium ions, to dehybridize a DNA molecule or to prevent hybridisation of a complementary ssDNA, wherein the SSB comprises the amino acid sequence of SEQ ID NO:1 or an amino acid sequence which is at least 75% identical to SEQ ID NO:1, or a functional fragment thereof, and wherein the DNA molecule or ssDNA is present in or exposed to a solution containing one or more of the following (i) at least 350 mM of sodium ions; (ii) at least 50 mM of potassium ions; (iii) at least 150 mM of magnesium ions; or (iv) at least 200 mM of calcium ions.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
• C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries

Abrégé

An apparatus (2) for volumetric imaging is provided. The apparatus (2) comprises an illumination assembly (8) arranged to direct light to illuminate a plurality of planes (22) in a sample region (4) sequentially at an illumination rate, each plane (22) extending over a plurality of depths (22a, 22b, 22c, 22d) in the sample region (4); an image sensor (6) comprising a plurality of sections of pixels (12) and arranged to sense each section of pixels (12) sequentially at a sensing rate; and a light-receiving assembly arranged to receive light from the sample region (4) and to direct light received from each of said planes (22) in the sample region (4) to a different respective section (12) of said sections of pixels. The light-receiving assembly comprises a multi-plane optical assembly (10) arranged to receive light from the plurality of depths (22a, 22b, 22c, 22d) in the sample region (4) and, for each section (12) of said sections of pixels, to direct light simultaneously from each of the plurality of depths (22a, 22b, 22c, 22d) in the respective plane (22) to a different respective subsection (12a, 12b, 12c, 12d) of said section (12). The illumination rate is equal to the sensing rate, such that each section of pixels (12) is arranged to sense light from the plurality of depths (22a, 22b, 22c, 22d) in the respective plane (22) as the plane is illuminated by the illumination assembly (8).

Classes IPC  ?

• G02B 21/00 - Microscopes
• G02B 21/08 - Condensateurs
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 27/10 - Systèmes divisant ou combinant des faisceaux
• H04N 3/14 - Détails des dispositifs de balayage des systèmes de télévisionLeur combinaison avec la production des tensions d'alimentation par des moyens non exclusivement optiques-mécaniques au moyen de dispositifs à l'état solide à balayage électronique

Abrégé

The present invention provides a DNA polymerase including the sequence of SEQ ID NO. 1 or a sequence which is at least 70% identical thereto, but wherein the aspartic acid residue at position 18 of SEQ ID NO. 1, or the equivalent aspartic acid residue in other sequences, has been replaced by a non-negatively charged amino acid residue. It further provides DNA polymerases comprising the amino acid sequences of SEQ ID NO. 2, 11 and 12 and variants thereof. The present invention also provides nucleic acids encoding the DNA polymerases, a method of producing said DNA polymerases, and compositions, expression vectors and host cells or viruses comprising said DNA polymerases. The present invention also provides uses of said DNA polymerases in nucleotide polymerisation, amplification, and sequencing reactions.

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques

Abrégé

The present invention relates generally to algaculture, and in particular to cultivation of diatoms. The present invention provides a growth medium for cultivation of diatoms in large volume vertical column bioreactors. Further, the invention also provides use of the growth medium for cultivation of diatoms as well as methods for cultivation of diatoms.

Classes IPC  ?

• C12N 1/12 - Algues unicellulairesLeurs milieux de culture
• C01B 33/00 - SiliciumSes composés
• C01B 33/113 - Oxydes de siliciumLeurs hydrates
• C01B 33/46 - Silicates amorphes, p. ex. zéolites dites "amorphes"

Abrégé

The invention concerns a jet-engine comprising an outer casing having an opening end for allowing inlet gas to enter therein, a combustor system comprising a combustor container enclosing a combustor chamber, a hot gas combustor inlet for allowing gas to enter within the combustor chamber and a fuel combustor inlet for allowing fuel to enter within the combustor chamber. A first end of the combustor container is arranged in fluid communication with an end of the outer casing opposite its opening end. The jet engine further comprises a fuel cell system employed to heat compressed gas prior to entering the combustor chamber and to provide electric power to electric components.

Classes IPC  ?

• F02C 1/05 - Ensembles fonctionnels de turbines à gaz caractérisés par l'utilisation de gaz chauds ou de gaz sous pression non chauffés, comme fluide de travail le fluide de travail étant chauffé indirectement caractérisés par le type ou la source de chaleur, p. ex. utilisant l'énergie nucléaire ou solaire
• F02K 3/10 - Ensembles fonctionnels comportant une turbine à gaz entraînant un compresseur ou un ventilateur soufflant avec réchauffage supplémentaire du fluide de travailLeur commande par postcombustion
• F02K 5/00 - Ensembles fonctionnels comportant un moteur, autre qu'une turbine à gaz, entraînant un compresseur ou un ventilateur soufflant

Abrégé

The present invention relates to a method for determining salt water readiness of salmonid fish, such as e.g. Atlantic salmon. In particular, the present invention relates to genetic markers useful in determining whether juvenile fish (parr) has transformed into a migratory form (smolt) that are ready for transfer to salt water.

Classes IPC  ?

• A01K 61/10 - Élevage des animaux aquatiques des poissons
• C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle

Abrégé

The present invention relates to a method for determining salt water readiness of salmonid fish, such as e.g. Atlantic salmon. In particular, the present invention relates to genetic markers useful in determining whether juvenile fish (parr) has transformed into a migratory form (smolt) that are ready for transfer to salt water.

Classes IPC  ?

• A01K 61/10 - Élevage des animaux aquatiques des poissons
• C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle

Abrégé

Aliivibrio wodanis are also provided.

Classes IPC  ?

• C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p. ex. glutathion
• C12N 9/16 - Hydrolases (3.) agissant sur les liaisons esters (3.1)

Abrégé

An optical component for illuminating a sample region with a periodic light pattern comprises: a first waveguide, a further waveguide and an optical splitter. The optical splitter has an input for receiving light, a first output and a second output. The first waveguide is optically coupled to the first output, to direct the first input light into the sample region in a first direction. The second output is optically coupled to the sample region to direct second input light into the sample region in a second direction. The further waveguide is arranged to receive third input light which is directed into the sample region in a third direction. The first direction, second direction and third direction are different from one another. The first and second input light interferes to form a periodic pattern in the sample region. The optical component may be used for structured illumination microscopy.

Classes IPC  ?

• G01J 4/00 - Mesure de la polarisation de la lumière
• G02B 21/00 - Microscopes
• G01N 21/64 - FluorescencePhosphorescence
• G02B 27/10 - Systèmes divisant ou combinant des faisceaux
• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée

Abrégé

The present invention relates to enzymes having DNA polymerase and 3'-5' exonuclease activities. In particular, the present invention relates to a heat labile enzyme possessing a DNA polymerase II activity and a 3'-5' exonuclease activity of marine origin. Furthermore, the present invention relates to a DNA polymerase primarily exerting a 3'-5' activity, i.e. where the polymerase activity is absent. The present invention furthermore relates to the use of the exonuclease activity to degrade the 3'-5' strand of double stranded DNA to perform single stranded overhang, e.g. in recombinant cloning processes, or in processes for removal of contaminating nucleic acid molecules.

Classes IPC  ?

• C12N 9/22 - Ribonucléases
• C12N 1/08 - Réduction de la teneur en acide nucléique
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12N 15/09 - Technologie d'ADN recombinant
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12N 15/55 - Hydrolases (3)
• C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides

Abrégé

The present invention relates to DNA polymerases. In particular, the present invention relates to heat labile DNA polymerases of marine origin, having high polymerase activity, strand displacement activity and 3'-5' exonuclease activity. Furthermore, the present invention provides heat labile DNA polymerases substantially without strand-displacement activity.

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• C12N 15/09 - Technologie d'ADN recombinant
• C12N 15/54 - Transférases (2)
• C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
• C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p. ex. glutathion
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The present invention relates to enzymes having DNA polymerase and 3'-5' exonuclease activities. In particular, the present invention relates to a heat labile enzyme possessing a DNA polymerase II activity and a 3'-5' exonuclease activity of marine origin. Furthermore, the present invention relates to a DNA polymerase primarily exerting a 3'-5' activity, i.e. where the polymerase activity is absent. The present invention furthermore relates to the use of the exonuclease activity to degrade the 3'-5' strand of double stranded DNA to perform single stranded overhang, e.g. in recombinant cloning processes, or in processes for removal of contaminating nucleic acid molecules.

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)

Abrégé

Transmission microscopy apparatus (2) comprises an illumination apparatus (10) arranged to illuminate a sample region (6) with first and second monochromatic coherent light beams (12, 14), and an objective lens (4), having an imaging axis (A), for collecting light emanating from a sample (8) within the sample region (6). In a first configuration the first light beam (12) enters the sample region (6) along a first linear path from a first reflecting element (328; 406a; 506a) and the second light beam (14) enters along a second linear path from a second reflecting element (330; 406b; 506b) such that the first and second light beams interfere within the sample region to illuminate the sample with a first interference pattern (16). In a second configuration the first light beam (12) enters the sample region (6) along a different, third linear path such that the first and second light beams (12, 14) illuminate the sample (8) with a different, second interference pattern (18) which is not the same as any translation, rotation, or translation and rotation of the first pattern (16). The first, second and third paths are at respective angles α1, α2, α3 to the imaging axis and at least one is oblique to the imaging axis.

Classes IPC  ?

• G02B 21/06 - Moyens pour éclairer un échantillon
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G01B 11/24 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer des contours ou des courbes
• G01N 21/64 - FluorescencePhosphorescence

Abrégé

The present invention relates to DNA polymerases. In particular, the present invention relates to heat labile DNA polymerases of marine origin, having high polymerase activity, strand displacement activity and 3'-5' exonuclease activity. Furthermore, the present invention provides heat labile DNA polymerases substantially without strand-displacement activity.

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)

Abrégé

Moritella viscoa Moritella viscoa and a thermolabile DNA polymerase I of marine origin in multi DNA assembly processes.

Classes IPC  ?

• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12N 15/64 - Méthodes générales pour la préparation du vecteur, pour son introduction dans la cellule ou pour la sélection de l'hôte contenant le vecteur

Abrégé

A film comprising a piezoelectric polymer has an upper surface and a lower surface. The film has an active region comprising the piezoelectric polymer, which extends from the upper surface of the film to the lower surface of the film. The film also comprises an adhesive sheet, which defines part of the upper or lower surface of the film. Circuit sheets may be bonded to the upper and lower surfaces in a lamination process to produce a laminated piezoelectric device.

Classes IPC  ?

• H01L 41/083 - Eléments piézo-électriques ou électrostrictifs avec une structure empilée ou multicouche
• B32B 27/06 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique
• C08L 27/12 - Compositions contenant des homopolymères ou des copolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, chacun ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un halogèneCompositions contenant des dérivés de tels polymères non modifiées par un post-traitement chimique contenant du fluor
• H01L 41/053 - Montures, supports, enveloppes ou boîtiers
• H01L 41/187 - Compositions céramiques
• H01L 41/193 - Compositions macromoléculaires
• H01L 41/29 - Formation d’électrodes, de connexions électriques ou de dispositions de bornes
• H04R 17/00 - Transducteurs piézo-électriquesTransducteurs électrostrictifs
• H01L 41/23 - Formation d'enceintes ou d'enveloppes
• H01L 41/45 - Matériaux organiques
• H01L 41/37 - Matériaux composites
• H01L 41/00 - DISPOSITIFS À SEMI-CONDUCTEURS; DISPOSITIFS ÉLECTRIQUES À L'ÉTAT SOLIDE NON PRÉVUS AILLEURS - Détails
• H01L 41/08 - Eléments piézo-électriques ou électrostrictifs
• H01L 41/16 - Emploi de matériaux spécifiés
• H01L 41/27 - Fabrication de dispositifs piézo-électriques ou électrostrictifs multicouches ou de leurs parties constitutives, p.ex. en empilant des corps piézo-électriques et des électrodes
• B32B 15/04 - Produits stratifiés composés essentiellement de métal comprenant un métal comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique

Abrégé

The present invention provides a DNA polymerase including the sequence of SEQ ID NO. 1 or a sequence which is at least 70% identical thereto, but wherein the aspartic acid residue at position 18 of SEQ ID NO. 1, or the equivalent aspartic acid residue in other sequences, has been replaced by a non-negatively charged amino acid residue. It further provides DNA polymerases comprising the amino acid sequences of SEQ ID NO. 2, 11 and 12 and variants thereof. The present invention also provides nucleic acids encoding the DNA polymerases, a method of producing said DNA polymerases, and compositions, expression vectors and host cells or viruses comprising said DNA polymerases. The present invention also provides uses of said DNA polymerases in nucleotide polymerisation, amplification and sequencing reactions.

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 15/54 - Transférases (2)

Abrégé

2; (ii) is substantially specific for single stranded DNA; and (iii) has a 3′-5′ exonuclease activity. The invention further provides a method of removing single stranded DNA from a sample, a method of nucleic acid amplification, a method of reverse transcription and a method of nucleic acid sequence analysis in which the exonuclease or enzymatically active fragment thereof is used. The invention still further provides nucleic acids encoding said exonuclease or an enzymatically active fragment thereof and kits or compositions comprising the same.

Classes IPC  ?

• C12Q 1/6869 - Méthodes de séquençage
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• C12N 9/22 - Ribonucléases
• C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
• G01N 1/30 - TeintureImprégnation

Abrégé

A method and a system for controlling an energy harvesting operation in a wireless terminal device, WT, have been disclosed. The method comprises the steps of determining (420), by an energy center point device, CP, if the WT needs to harvest energy; and transmitting (430), by the CP, energy harvesting information to WT, the energy harvesting information identifying time slots in which the WT may harvest energy. Harvesting may be performed during the time slots identified by the energy harvesting information. Embodiments include CP initiated and WT initiated energy harvesting operations. The method and system may be implemented in a standard wireless communication protocol, such as Zigbee/IEEE 802.15.4. Energy harvesting information may be transmitted in a modified frame in the wireless communication protocol.

Classes IPC  ?

• H02J 50/00 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique
• H02J 50/80 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique mettant en œuvre l’échange de données, concernant l’alimentation ou la distribution d’énergie électrique, entre les dispositifs de transmission et les dispositifs de réception
• H04B 1/00 - Détails des systèmes de transmission, non couverts par l'un des groupes Détails des systèmes de transmission non caractérisés par le milieu utilisé pour la transmission

Abrégé

The present invention relates to a wash bottle for storing and dispensing a liquid, where the wash bottle comprises a bottle body having flexible sidewalls defining an interior reservoir and an open end providing access to the interior reservoir, a closure connected to the open end, a dispensing tube having a first end being in communication with the interior reservoir and an opposite second end being in communication with ambient air outside the wash bottle, where a back-flush valve is connected to at least one of the first and second ends of the dispensing tube, or the back flush valve is arranged arbitrary between the first and second end of the dispensing tube and where a vent valve is provided in the closure.

Classes IPC  ?

• B01L 3/10 - Flacons laveurs
• B05B 11/04 - Récipients déformables produisant l’écoulement, p. ex. bouteilles compressibles
• B65D 83/00 - Réceptacles ou paquets comportant des moyens particuliers pour distribuer leur contenu

Abrégé

The present invention relates generally to the field of inflammatory bowel disease (IBD), and in particular ulcerative colitis (UC). The present invention provides methods for predicting clinical course of UC in a patient. By being able to predict the clinical course of UC, it is now possible to conclude on a therapeutic approach adapted to reflect the actual clinical picture of the patient at an early stage. Such a diagnostic test will create new knowledge of high clinical utility for the clinician, create a personalized therapy for the patient, improve the prognosis for the patient and reduce health costs for the society.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present invention relates to bioactive cyclic compounds and their use as antimicrobial agents. In particular, the present invention relates to barbiturate mimics of Eusynstyelamides or small antimicrobial peptides. The compounds of the invention are represented by Formula (I). (I)

Classes IPC  ?

• C07D 239/62 - Acides barbituriques
• A61P 31/04 - Agents antibactériens

Abrégé

The present invention concerns a rechargeable iron-ion (Fe-ion) battery cell comprising an anode, a cathode, and an electrolyte interposed between the anode and the cathode, and the use thereof. The electrolyte itself may comprise the Fe-ions, and/or can obtain the Fe-ions from the anode or cathode. A Fe-ion refers to an ion containing Fe element. The cathode is preferably made of Fe element containing materials. Aqueous electrolyte and organic electrolyte may be utilized as electrolyte for Fe-ion battery fabrication. In order to further improve the performance of Fe-ion battery, ionic liquid may be utilized as electrolyte, wherein the ionic liquid electrolyte transports Fe-ions between said anode and cathode.

Classes IPC  ?

• H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p. ex. au magnésium ou à l'aluminium

Abrégé

Aliivibrio wodanisAliivibrio wodanisAliivibrio wodanis are also provided.

Classes IPC  ?

• C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p. ex. glutathion

Abrégé

The present invention relates to the use of a single-strand DNA binding protein (SSB) which exhibits at least 50% of its maximum ssDNA binding capability in the presence of 500 mM of sodium ions, to dehybridize a DNA molecule or to prevent hybridisation of a complementary ssDNA, wherein the SSB comprises the amino acid sequence of SEQ ID NO:1 or an amino acid sequence which is at least 75% identical to SEQ ID NO:1, or a functional fragment thereof, and wherein the DNA molecule or ssDNA is present in or exposed to a solution containing one or more of the following (i) at least 350 mM of sodium ions; (ii) at least 50 mM of potassium ions; (iii) at least 150 mM of magnesium ions; or (iv) at least 200 mM of calcium ions.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
• C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries

Abrégé

A film (1) comprising a piezoelectric polymer (2) has an upper surface and a lower surface. The film has an active region comprising the piezoelectric polymer (2), which extends from the upper surface of the film to the lower surface of the film. The film also comprises an adhesive sheet (3), which defines part of the upper or lower surface of the film. Circuit sheets (4, 5) may be bonded to the upper and lower surfaces in a lamination process to produce a laminated piezoelectric device.

Classes IPC  ?

• H01L 41/27 - Fabrication de dispositifs piézo-électriques ou électrostrictifs multicouches ou de leurs parties constitutives, p.ex. en empilant des corps piézo-électriques et des électrodes
• B32B 27/06 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique
• C08L 27/12 - Compositions contenant des homopolymères ou des copolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, chacun ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un halogèneCompositions contenant des dérivés de tels polymères non modifiées par un post-traitement chimique contenant du fluor
• H01L 41/053 - Montures, supports, enveloppes ou boîtiers
• H01L 41/187 - Compositions céramiques
• H01L 41/193 - Compositions macromoléculaires
• H01L 41/29 - Formation d’électrodes, de connexions électriques ou de dispositions de bornes
• H04R 17/00 - Transducteurs piézo-électriquesTransducteurs électrostrictifs
• H01L 41/083 - Eléments piézo-électriques ou électrostrictifs avec une structure empilée ou multicouche
• H01L 41/23 - Formation d'enceintes ou d'enveloppes
• H01L 41/45 - Matériaux organiques
• H01L 41/37 - Matériaux composites
• H01L 41/00 - DISPOSITIFS À SEMI-CONDUCTEURS; DISPOSITIFS ÉLECTRIQUES À L'ÉTAT SOLIDE NON PRÉVUS AILLEURS - Détails
• H01L 41/08 - Eléments piézo-électriques ou électrostrictifs
• H01L 41/16 - Emploi de matériaux spécifiés
• B32B 15/04 - Produits stratifiés composés essentiellement de métal comprenant un métal comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique

Abrégé

The present invention provides a DNA polymerase including the sequence of SEQ ID NO. 1 or a sequence which is at least 70% identical thereto, but wherein the aspartic acid residue at position 18 of SEQ ID NO. 1, or the equivalent aspartic acid residue in other sequences, has been replaced by a non-negatively charged amino acid residue. It further provides DNA polymerases comprising the amino acid sequences of SEQ ID NO. 2, 11 and 12 and variants thereof. The present invention also provides nucleic acids encoding the DNA polymerases, a method of producing said DNA polymerases, and compositions, expression vectors and host cells or viruses comprising said DNA polymerases. The present invention also provides uses of said DNA polymerases in nucleotide polymerisation, amplification and sequencing reactions.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)

Abrégé

The present invention provides a DNA polymerase including the sequence of SEQ ID NO. 1 or a sequence which is at least 70% identical thereto, but wherein the aspartic acid residue at position 18 of SEQ ID NO. 1, or the equivalent aspartic acid residue in other sequences, has been replaced by a non-negatively charged amino acid residue. It further provides DNA polymerases comprising the amino acid sequences of SEQ ID NO. 2, 11 and 12 and variants thereof. The present invention also provides nucleic acids encoding the DNA polymerases, a method of producing said DNA polymerases, and compositions, expression vectors and host cells or viruses comprising said DNA polymerases. The present invention also provides uses of said DNA polymerases in nucleotide polymerisation, amplification and sequencing reactions.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)

Abrégé

Psychrobacillus sp. The present invention provides an isolated DNA polymerase or an enzymatically active fragment thereof, said DNA polymerase comprising the amino acid sequence of SEQ ID NO:1 or comprising an amino acid sequence which is at least 70% identical to SEQ ID NO:1. The invention also provides nucleic acid molecules comprising a nucleotide sequence that encodes the DNA polymerase. The invention also provides a method of nucleotide polymerisation and a method of amplifying a nucleic acid in which the DNA polymerase or an enzymatically active fragment thereof is used.

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques

Abrégé

2; (ii) is substantially specific for single stranded DNA; and (iii) has a 3′-5′ exonuclease activity. The invention further provides a method of removing single stranded DNA from a sample, a method of nucleic acid amplification, a method of reverse transcription and a method of nucleic acid sequence analysis in which the exonuclease or enzymatically active fragment thereof is used. The invention still further provides nucleic acids encoding said exonuclease or an enzymatically active fragment thereof and kits or compositions comprising the same.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• C12N 9/16 - Hydrolases (3.) agissant sur les liaisons esters (3.1)
• C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
• C12N 9/22 - Ribonucléases
• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
• G01N 1/30 - TeintureImprégnation

Abrégé

An optical component (910) for illuminating a sample region (955) with a periodic light pattern comprises: a first waveguide (914), a further waveguide (916, 917, 918, 919) and an optical splitter (913a). The optical splitter (913a) has an input (911) for receiving light, a first output and a second output. The first waveguide (914) is optically coupled to the first output, to direct the first input light into the sample region (955) in a first direction (914a). The second output is optically coupled to the sample region (955) to direct second input light into the sample region (955) in a second direction (915a). The further waveguide (916, 917, 918, 919) is arranged to receive third input light which is directed into the sample region in a third direction (916a, 917a, 918a, 919a). The first direction (914a), second direction (915a) and third direction (916a, 917a, 918a, 919a) are different from one another. The first and second input light interferes to form a periodic pattern in the sample region (955). The optical component (910) may be used for structured illumination microscopy.

Classes IPC  ?

• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée
• G02B 21/00 - Microscopes
• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/24 - Structure du bâti ou statif

Abrégé

An optical component (910) for illuminating a sample region (955) with a periodic light pattern comprises: a first waveguide (914), a further waveguide (916, 917, 918, 919) and an optical splitter (913a). The optical splitter (913a) has an input (911) for receiving light, a first output and a second output. The first waveguide (914) is optically coupled to the first output, to direct the first input light into the sample region (955) in a first direction (914a). The second output is optically coupled to the sample region (955) to direct second input light into the sample region (955) in a second direction (915a). The further waveguide (916, 917, 918, 919) is arranged to receive third input light which is directed into the sample region in a third direction (916a, 917a, 918a, 919a). The first direction (914a), second direction (915a) and third direction (916a, 917a, 918a, 919a) are different from one another. The first and second input light interferes to form a periodic pattern in the sample region (955). The optical component (910) may be used for structured illumination microscopy.

Classes IPC  ?

• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée
• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes
• G02B 21/24 - Structure du bâti ou statif

Abrégé

The present invention relates to bioactive cyclic compounds and their use as antimicrobial agents. In particular, the present invention relates to barbiturate mimics of Eusynstyelamides or small antimicrobial peptides. The compounds of the invention are represented by Formula (I). (I)

Classes IPC  ?

• C07D 239/64 - Sels des bases organiquesComposés organiques doubles
• A61K 31/515 - Acides barbituriquesLeurs dérivés, p. ex. pentobarbital sodique
• A61P 31/00 - Agents anti-infectieux, c.-à-d. antibiotiques, antiseptiques, chimiothérapeutiques
• A61P 35/00 - Agents anticancéreux
• C07D 233/96 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques

Abrégé

The present invention relates to bioactive cyclic compounds and their use as antimicrobial agents. In particular, the present invention relates to barbiturate mimics of Eusynstyelamides or small antimicrobial peptides. The compounds of the invention are represented by Formula (I). (I)

Classes IPC  ?

• C07D 233/96 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
• A61K 31/515 - Acides barbituriquesLeurs dérivés, p. ex. pentobarbital sodique
• A61P 35/00 - Agents anticancéreux
• A61P 31/00 - Agents anti-infectieux, c.-à-d. antibiotiques, antiseptiques, chimiothérapeutiques

Abrégé

The present invention relates to the use of a single-strand DNA binding protein (SSB) which exhibits at least 50% of its maximum ssDNA binding capability in the presence of 500mM of sodium ions, to dehybridize a DNA molecule or to prevent hybridisation of a complementary ssDNA, wherein the SSB comprises the amino acid sequence of SEQ ID NO:1 or an amino acid sequence which is at least 75% identical to SEQ ID NO:1, or a functional fragment thereof, and wherein the DNA molecule or ssDNA is present in or exposed to a solution containing one or more of the following (i) at least 350mM of sodium ions; (ii) at least 50mM of potassium ions; (iii) at least 150mM of magnesium ions; or (iv) at least 200mM of calcium ions.

Classes IPC  ?

• C12N 15/31 - Gènes codant pour des protéines microbiennes, p. ex. entérotoxines
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• C12Q 1/6865 - Amplification à base de promoteurs, p. ex. amplification de séquence d’acide nucléique [NASBA], système de réplication de séquence auto-entretenue [3SR] ou d’amplification à base de transcription [TAS]
• C12Q 1/6869 - Méthodes de séquençage
• C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The present invention relates to the use of a single-strand DNA binding protein (SSB) which exhibits at least 50% of its maximum ssDNA binding capability in the presence of 500mM of sodium ions, to dehybridize a DNA molecule or to prevent hybridisation of a complementary ssDNA, wherein the SSB comprises the amino acid sequence of SEQ ID NO:1 or an amino acid sequence which is at least 75% identical to SEQ ID NO:1, or a functional fragment thereof, and wherein the DNA molecule or ssDNA is present in or exposed to a solution containing one or more of the following (i) at least 350mM of sodium ions; (ii) at least 50mM of potassium ions; (iii) at least 150mM of magnesium ions; or (iv) at least 200mM of calcium ions.

Classes IPC  ?

• C12Q 1/6813 - Tests d’hybridation
• C12Q 1/6832 - Amélioration de la réaction d’hybridation

Abrégé

The present invention relates to peptides of SEQ ID NO: 27 and peptidomimetics thereof and to their use as antimicrobial and anticancer agents. Said peptides being based on the heavy chain (HC) of a centrocin from the sea urchin Echinus esculentus.

Classes IPC  ?

• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains

Abrégé

A film (1) comprising a piezoelectric polymer (2) has an upper surface and a lower surface. The film has an active region comprising the piezoelectric polymer (2), which extends from the upper surface of the film to the lower surface of the film. The film also comprises an adhesive sheet (3), which defines part of the upper or lower surface of the film. Circuit sheets (4, 5) may be bonded to the upper and lower surfaces in a lamination process to produce a laminated piezoelectric device.

Classes IPC  ?

• H01L 41/053 - Montures, supports, enveloppes ou boîtiers
• H01L 41/193 - Compositions macromoléculaires
• H01L 41/29 - Formation d’électrodes, de connexions électriques ou de dispositions de bornes
• H04R 17/00 - Transducteurs piézo-électriquesTransducteurs électrostrictifs

Abrégé

A film (1) comprising a piezoelectric polymer (2) has an upper surface and a lower surface. The film has an active region comprising the piezoelectric polymer (2), which extends from the upper surface of the film to the lower surface of the film. The film also comprises an adhesive sheet (3), which defines part of the upper or lower surface of the film. Circuit sheets (4, 5) may be bonded to the upper and lower surfaces in a lamination process to produce a laminated piezoelectric device.

Classes IPC  ?

• H10N 30/80 - Détails de structure
• H10N 30/073 - Formation de parties ou de corps piézo-électriques ou électrostrictifs sur un élément électrique ou sur un autre support par laminage ou collage de corps piézo-électriques ou électrostrictifs par fusion de métaux ou par adhésifs
• H10N 30/85 - Matériaux actifs piézo-électriques ou électrostrictifs
• H10N 30/87 - Électrodes ou interconnexions, p. ex. connexions électriques ou bornes
• C09J 7/10 - Adhésifs sous forme de films ou de pellicules sans support
• B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
• H04R 17/00 - Transducteurs piézo-électriquesTransducteurs électrostrictifs

Abrégé

An apparatus, for super-resolution imaging of a sample, comprising: an objective lens (4) that collects light emanating from the sample (2) within a forward field of view (30); a processing arrangement (20) that performs super-resolution imaging of the sample with the collected light; a waveguide component (1) arranged to (i) receive input light from outside the field of view, and (ii) use total internal reflection within the waveguide component to direct excitation light onto the sample; and an electronic optical-path control system (40) that causes the input light to: follow, at a first time, a first optical path corresponding to a first optical mode within the waveguide component; and follow, at a second time, a second optical path corresponding to a second optical mode within the waveguide component, wherein the second time is different from the first time, and the second optical mode is different from the first optical mode.

Classes IPC  ?

• G02B 21/16 - Microscopes adaptés pour éclairage ultraviolet
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 27/56 - Optique utilisant des ondes évanescentes, c.-à-d. ondes non homogènes
• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée

Abrégé

An apparatus, for super-resolution imaging of a sample, comprising: an objective lens (4) that collects light emanating from the sample (2) within a forward field of view (30); a processing arrangement (20) that performs super-resolution imaging of the sample with the collected light; a waveguide component (1) arranged to (i) receive input light from outside the field of view, and (ii) use total internal reflection within the waveguide component to direct excitation light onto the sample; and an electronic optical-path control system (40) that causes the input light to: follow, at a first time, a first optical path corresponding to a first optical mode within the waveguide component; and follow, at a second time, a second optical path corresponding to a second optical mode within the waveguide component, wherein the second time is different from the first time, and the second optical mode is different from the first optical mode.

Classes IPC  ?

• G02B 21/16 - Microscopes adaptés pour éclairage ultraviolet
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 27/56 - Optique utilisant des ondes évanescentes, c.-à-d. ondes non homogènes
• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée

Abrégé

The present invention relates to DNA polymerases. In particular, the present invention relates to DNA polymerases based on a DNA polymerase from a Psychrobacillus sp. The present invention provides an isolated DNA polymerase or an enzymatically active fragment thereof, said DNA polymerase comprising the amino acid sequence of SEQ ID NO:1 or comprising an amino acid sequence which is at least 70% identical to SEQ ID NO:1. The invention also provides nucleic acid molecules comprising a nucleotide sequence that encodes the DNA polymerase. The invention also provides a method of nucleotide polymerisation and a method of amplifying a nucleic acid in which the DNA polymerase or an enzymatically active fragment thereof is used.

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)

Abrégé

The present invention relates to DNA polymerases. In particular, the present invention relates to DNA polymerases based on a DNA polymerase from a Psychrobacillus sp. The present invention provides an isolated DNA polymerase or an enzymatically active fragment thereof, said DNA polymerase comprising the amino acid sequence of SEQ ID NO:1 or comprising an amino acid sequence which is at least 70% identical to SEQ ID NO:1. The invention also provides nucleic acid molecules comprising a nucleotide sequence that encodes the DNA polymerase. The invention also provides a method of nucleotide polymerisation and a method of amplifying a nucleic acid in which the DNA polymerase or an enzymatically active fragment thereof is used.

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)

Abrégé

2; (ii) is substantially specific for single stranded DNA; and (iii) has a 3′-5′ exonuclease activity. The invention further provides a method of removing single stranded DNA from a sample, a method of nucleic acid amplification, a method of reverse transcription and a method of nucleic acid sequence analysis in which the exonuclease or enzymatically active fragment thereof is used. The invention still further provides nucleic acids encoding said exonuclease or an enzymatically active fragment thereof and kits or compositions comprising the same.

Classes IPC  ?

• C12N 9/22 - Ribonucléases
• C12Q 1/686 - Réaction en chaine par polymérase [PCR]
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
• G01N 1/30 - TeintureImprégnation

Abrégé

The invention provides an exonuclease or an enzymatically active fragment thereof, said exonuclease having the amino acid sequence of SEQ ID No. 1 or an amino acid sequence which is at least about 50% identical thereto, wherein said exonuclease or enzymatically active fragment thereof (i) is substantially irreversibly inactivated by heating at a temperature of about 55 °C for 10 minutes in a buffer consisting of 10 mM Tris-HCI, pH 8.5 at 25 °C, 50 mM KCI and 5 mM MgCI2; (ii) is substantially specific for single stranded DNA; and (iii) has a 3'-5' exonuclease activity. The invention further provides a method of removing single stranded DNA from a sample, a method of nucleic acid amplification, a method of reverse transcription and a method of nucleic acid sequence analysis in which the exonuclease or enzymatically active fragment thereof is used. The invention still further provides nucleic acids encoding said exonuclease or an enzymatically active fragment thereof and kits or compositions comprising the same.

Classes IPC  ?

• C12N 9/22 - Ribonucléases
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
• C12Q 1/6813 - Tests d’hybridation
• C12Q 1/6869 - Méthodes de séquençage
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12N 15/55 - Hydrolases (3)
• C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides

Abrégé

The invention provides an exonuclease or an enzymatically active fragment thereof, said exonuclease having the amino acid sequence of SEQ ID No. 1 or an amino acid sequence which is at least about 50% identical thereto, wherein said exonuclease or enzymatically active fragment thereof (i) is substantially irreversibly inactivated by heating at a temperature of about 55 °C for 10 minutes in a buffer consisting of 10 mM Tris-HCI, pH 8.5 at 25 °C, 50 mM KCI and 5 mM MgCI2; (ii) is substantially specific for single stranded DNA; and (iii) has a 3'-5' exonuclease activity. The invention further provides a method of removing single stranded DNA from a sample, a method of nucleic acid amplification, a method of reverse transcription and a method of nucleic acid sequence analysis in which the exonuclease or enzymatically active fragment thereof is used. The invention still further provides nucleic acids encoding said exonuclease or an enzymatically active fragment thereof and kits or compositions comprising the same.

Classes IPC  ?

• C12N 9/22 - Ribonucléases

Abrégé

The present invention provides to methods for the production of neuraminic acid or derivatives thereof under alkaline conditions and to the use of neuraminate lyases showing improved characteristics under alkaline conditions in the production of neuraminic acid or its derivatives. More particularly, the present invention employs inter alia a N-acetylneuraminate lyase which has been isolated from the psychrophilic bacterium Aliivibrio salmonicida LFI1238 and has shown to have improved characteristics under alkaline conditions.

Classes IPC  ?

• C12P 19/28 - N-glucosides
• C12N 9/88 - Lyases (4.)

Abrégé

The present invention provides an isolated antibody that specifically binds to HPA- a. Also provided is a nucleic acid molecule that encodes the antibody, and compositions comprising the antibody. Also provided is a method of producing the antibody and methods and uses which employ the antibody. Also provided are therapeutic uses of the antibody, for example in the treatment or prophylaxis of fetal and neonatal alloimmune thrombocytopenia (FNAIT).

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire

Abrégé

The present invention provides a peptide which: (i) consists of 10 to 16 amino acids; (ii) has at least 8 cationic amino acids with either (a) a side chain comprising a guanidinium group, or (b) a side chain comprising an amino group, of which no more than 7 are consecutive; and (iii) has 2 or 3 tryptophan residues which are not both, or not all, consecutive, said peptide optionally in the form of a salt, ester or amide, or a peptidomimetic of said peptide. The invention further relates to pharmaceutical compositions containing these compounds, the use of these compounds in therapy, particularly as anti-tumour (e.g. anti-lymphoma) agents and non-therapeutic uses of these compounds.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides

Abrégé

The present invention provides a peptide which: (i) consists of 10 to 16 amino acids; (ii) has at least 8 cationic amino acids with either (a) a side chain comprising a guanidinium group, or (b) a side chain comprising an amino group, of which no more than 7 are consecutive; and (iii) has 2 or 3 tryptophan residues which are not both, or not all, consecutive, said peptide optionally in the form of a salt, ester or amide, or a peptidomimetic of said peptide. The invention further relates to pharmaceutical compositions containing these compounds, the use of these compounds in therapy, particularly as anti-tumour (e.g. anti-lymphoma) agents and non-therapeutic uses of these compounds.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides