Abrégé

A vaccine for the treatment or prevention of Pseudomonas aeruginosa infection in a subject. A composition comprising one or more immunogens is provided. The composition is for use in vaccine therapy to treat or prevent P. aeruginosa infection in subject.

Classes IPC  ?

• A61K 39/104 - Pseudomonas
• C07K 14/21 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Pseudomonadaceae (F)
• C07K 16/12 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de bactéries
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire

Abrégé

A microneedle for transdermal drug delivery, the microneedle comprising an input channel extending through the microneedle along a longitudinal axis of the microneedle, the input channel defining a sidewall, a first end, and a second end, the input channel configured to receive fluid input into the microneedle. The microneedle comprises one or more outlet channels extending between an interior surface of the sidewall, and an exterior surface of the sidewall, such that each of the one or more outlet channels define a fluid path between the input channel and the exterior surface of the sidewall. The one or more outlet channels are angled relative to the longitudinal axis of the microneedle at an angle which is greater than 0° and less than 90°.

Classes IPC  ?

• A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau

Abrégé

Broadly speaking, the present techniques generally relate to a method for processing images of an organ (or part thereof) using a trained machine learning, ML, model in order to more efficiently and accurately provide information on different tissue regions of the organ. Advantageously, the ML model generates an augmented image of the organ showing the different tissue regions, such as diseased tissue regions and healthy tissue regions. This may help a surgeon to decide where to perform a surgical intervention in a way that only diseased tissue is excised.

Classes IPC  ?

• G06T 7/11 - Découpage basé sur les zones
• G06T 7/194 - DécoupageDétection de bords impliquant une segmentation premier plan-arrière-plan

Abrégé

The present invention relates to diagnostic and prognostic methods and their use in diagnosing or predicting disease progression in a subject with Ulcerative Colitis (UC). More particularly, the present invention relates to a gene expression signature and the use thereof in determining the likelihood of progression of Ulcerative Colitis in a subject, as well as compositions for the detection thereof. The invention also extends to the use of biomarkers as targets to improve the treatment of Ulcerative Colitis in patients.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

A fractional frequency divider configured to suppress spurious tones resulting from requantization of an accumulated quantization error has a multi-modulus divider (MMD) and one or more digital-to-time converters (DTCs). Each DTC includes a gain and/or digital predistortion, a dithered requantizer having a multibit input signa, a multibit output signal, and a multibit digitally-controllable delay (DCD). The quantized time delay between the input and output of the DTC is determined by the input from the MMD controller, the gain/digital predistortion and the requantizer. The MMD controller provides an input to the DTC that is proportional to the accumulated time quantization error introduced by the MMD controller, the gain/digital predistortion scales by a gain factor to produce a signal (a[k]) that is combined with a discrete-valued dither signal in the dithered requantizer to provide the control input of the DCD.

Classes IPC  ?

• H03K 21/08 - Circuits de sortie
• H03K 5/00 - Transformation d'impulsions non couvertes par l'un des autres groupes principaux de la présente sous-classe
• H03K 5/1252 - Suppression ou limitation du bruit ou des interférences

Abrégé

1212122, and CTH assayed from a biological sample from the subject with no cancer, the individual is predicted to have an increased probability of having disease free status and having an increased chance of overall survival.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention relates to diagnostic and prognostic methods and their use in diagnosing or predicting disease progression in a subject with colorectal cancer (CRC). More particularly, the present invention relates to a gene expression signature and the use thereof in determining the likelihood of progression of CRC to metastatic CRC (mCRC) in a subject, as well as compositions for the detection thereof. The present invention also extends to clinical markers and compositions for use in the treatment and/or prognosis of CRC and in particular mCRC.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention is concerned with an endovascular occlusion device for use in occluding a lumen of the endovascular system to treat certain medical conditions such as vascular malformations, bleeding vessels or occluding vessels in order to induce tissue ischemia or necrosis, the occlusion device including a deformable sleeve displaceable between a collapsed state and an expanded state and a conical array of cantilevered arms extending from a distal end of the sleeve and converging towards distal tips such as to define a first haemostatic valve about the distal end of the sleeve. The distal end of the sleeve will be at least partially covered with a polymer fluid impermeable membrane in order to provide a seal to prevent fluid flow through the occlusion device. The internal valve will be haemostatic regardless of the initial direction of blood flow and will allow distal endovascular delivery of a surgical instrument such as a catheter that can be manipulated and used to deliver therapeutic agents such as liquid or small particle embolics.

Classes IPC  ?

• A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux

Abrégé

The present disclosure describes a charging system for directing power flow between multiple devices. The charging system can include a connector box including a vehicle inlet port configured to receive a vehicle connector configured to connect to a direct current (DC) or alternating current (AC) vehicle charging station; a locking mechanism configured to secure the vehicle connector within the vehicle inlet port, wherein the locking mechanism is configured to be activated upon insertion of the vehicle connector into the vehicle inlet port and remain activated until deactivation by an authorized user; and an outlet port configured to supply electrical power received via the vehicle inlet port and to an apparatus, the apparatus configured to supply the electrical power from the outlet port to a vehicle connected to the apparatus in a vehicle charging session.

Classes IPC  ?

• B60L 53/16 - Connecteurs, p. ex. fiches ou prises, spécialement adaptés pour recharger des véhicules électriques
• B60L 53/18 - Câbles spécialement adaptés pour recharger des véhicules électriques
• B60L 53/30 - Détails de construction des stations de charge
• B60L 53/66 - Transfert de données entre les stations de charge et le véhicule
• B60L 53/68 - Surveillance ou commande hors site, p. ex. télécommande

Abrégé

Disclosed is a computer-implemented method for real-time classification of cells in a body tissue that includes capturing one or more images of a cytology slide sample of the body tissue, pre-processing the captured one or more images, detecting and extracting a plurality of regions of interest in the pre-processed images using a cell detection process, wherein each region of interest includes one or more cells or cell clusters of interest, segmenting each individual cell or cluster in the regions of interest and extracting pixel content of each segmented cell or cluster, extracting semantic features from each segmented cell image using an embedding extraction model, classifying each individual cell or cell cluster based on corresponding extracted sematic features, and predicting a class of the cytology slide sample, based on one or more positions and relationships among one or more classified cells, using a slide level decision model.

Classes IPC  ?

• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G06V 10/426 - Représentations graphiques
• G06V 10/762 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant le regroupement, p. ex. de visages similaires sur les réseaux sociaux
• G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
• G06T 7/00 - Analyse d'image

Abrégé

This invention relates to a computer-implemented method and system for performing security evaluation on a machine learning (ML) model. The method includes determining a taxonomy of the ML model and of the environment in which the machine learning model is implemented at one or more stages in the model's lifecycle. The method additionally includes generating, based on the determined taxonomy, a set of assumptions about the ML model and the environment. An adversarial test attack is performed on the ML model at a stage in its lifecycle, based at least in part on the set of assumptions, and one or more failure modes in the ML model are identified based on the result of the first adversarial attack. The system may include a threat modelling component, an assessment component, a reporting component, and a risk mitigation component.

Classes IPC  ?

• G06N 20/00 - Apprentissage automatique

Abrégé

The present disclosure describes a vehicle charging system comprising a vehicle charging gun comprising at least two pins, a protective earth (PE) pin configured to connect to ground and a proximity pilot (PP) pin configured to detect when the vehicle charging gun has been inserted into a vehicle; and an apparatus to couple with the vehicle charging gun, the apparatus comprising: a switch operable between a first position and a second position, the switch being controlled by a controller, wherein, when the switch is in the first position, the switch enables the vehicle or a vehicle charging station to detect that the vehicle charging gun is inserted into a vehicle inlet port of the vehicle, and when the switch is in the second position, the apparatus generates an electrical effect that simulates the removal of the vehicle charging gun from the vehicle inlet port.

Classes IPC  ?

• H02J 7/00 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries
• B60L 53/10 - Procédés de chargement de batteries spécialement adaptées aux véhicules électriquesStations de charge ou équipements de charge embarqués pour ces batteriesÉchange d'éléments d’emmagasinage d'énergie dans les véhicules électriques caractérisés par le transfert d’énergie entre la station de charge et le véhicule
• B60L 53/12 - Transfert d'énergie par induction
• B60L 53/14 - Transfert d'énergie par conduction
• B60L 53/16 - Connecteurs, p. ex. fiches ou prises, spécialement adaptés pour recharger des véhicules électriques
• B60L 53/60 - Surveillance et commande des stations de charge
• B60L 53/66 - Transfert de données entre les stations de charge et le véhicule
• B60L 53/67 - Commande de plusieurs stations de charge
• B60L 55/00 - Dispositions relatives à la fourniture d'énergie emmagasinée dans un véhicule à un réseau électrique, c.-à-d. du véhicule au réseau [V2G]
• H01R 13/639 - Moyens additionnels pour maintenir ou verrouiller les pièces de couplage entre elles après l'engagement
• H02J 3/14 - Circuits pour réseaux principaux ou de distribution, à courant alternatif pour règler la tension dans des réseaux à courant alternatif par changement d'une caractéristique de la charge du réseau par interruption, ou mise en circuit, des charges du réseau, p. ex. charge équilibrée progressivement

Abrégé

A device (1) is provided for controlling transmission of electromagnetic radiation through a transparent substrate. The device comprises a first plurality of electrodes (5a, 5b) arranged as a first layer (2) and a second plurality of electrodes (8a, 8b) arranged as a second layer (4) spaced apart from the first layer. A carrier material (6) is located between the first plurality of electrodes and the second plurality of electrodes comprising a plurality of molecules (10) configured to change their orientation in the presence of an electric field thereby to alter the transmission of electromagnetic radiation through the device. The first plurality of electrodes and the second plurality of electrodes are configured to generate an electric field in the carrier material upon application of a potential difference between the first and second plurality of electrodes, to alter the transmission of electromagnetic radiation through the device.

Classes IPC  ?

• G02F 1/169 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des particules orientables non sphériques ayant une caractéristique optique commune, p. ex. des particules suspendues de copeaux de métal réfléchissant
• E06B 9/24 - Écrans ou autres dispositifs protecteurs contre la lumière, notamment contre la lumière solaireÉcrans similaires pour protection de l'intimité ou pour des raisons esthétiques

Abrégé

A computer implemented method of generating a restructured graph-based dataset (100b) of transactions within a public ledger, the method comprising: providing an original graph-based dataset (100a) of transactions within a public ledger, the original graph-based dataset (100a) comprising nodes (102, 104, 106) and edges (110, 112); determining a relatedness score for each of a plurality of pairs of nodes (102, 104, 106) in the original graph -based dataset (100a); and for each of the pairs of nodes (102, 104, 106): comparing the relatedness score to a threshold; and updating the original graph-based dataset (100a) to include a new edge (114) between the pair of nodes (102, 104, 106) if the relatedness score exceeds the threshold.

Classes IPC  ?

• G06N 3/082 - Méthodes d'apprentissage modifiant l’architecture, p. ex. par ajout, suppression ou mise sous silence de nœuds ou de connexions
• G06F 18/2323 - Techniques non hiérarchiques basées sur la théorie des graphes, p. ex. les arbres couvrants de poids minimal [MST] ou les coupes de graphes
• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 5/022 - Ingénierie de la connaissanceAcquisition de la connaissance
• G06Q 50/26 - Services gouvernementaux ou services publics
• G06Q 20/40 - Autorisation, p. ex. identification du payeur ou du bénéficiaire, vérification des références du client ou du magasinExamen et approbation des payeurs, p. ex. contrôle des lignes de crédit ou des listes négatives

Abrégé

The present disclosure describes a connector box, comprising a vehicle inlet port configured to receive a vehicle connector configured to connect to a direct current (DC) or alternating current (AC) vehicle charging station; a locking mechanism configured to secure the vehicle connector within the vehicle inlet port, wherein the locking mechanism is configured to be activated upon insertion of the vehicle connector into the vehicle inlet port and remain activated until deactivation by an authorized user; and an outlet port configured to supply electrical power received via the vehicle inlet port and to an apparatus, the apparatus configured to supply the electrical power from the outlet port to a vehicle connected to the apparatus in a vehicle charging session.

Classes IPC  ?

• H02J 7/00 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries
• B60L 53/10 - Procédés de chargement de batteries spécialement adaptées aux véhicules électriquesStations de charge ou équipements de charge embarqués pour ces batteriesÉchange d'éléments d’emmagasinage d'énergie dans les véhicules électriques caractérisés par le transfert d’énergie entre la station de charge et le véhicule
• B60L 53/12 - Transfert d'énergie par induction
• B60L 53/14 - Transfert d'énergie par conduction
• B60L 53/16 - Connecteurs, p. ex. fiches ou prises, spécialement adaptés pour recharger des véhicules électriques
• B60L 53/60 - Surveillance et commande des stations de charge
• B60L 53/66 - Transfert de données entre les stations de charge et le véhicule
• B60L 53/67 - Commande de plusieurs stations de charge
• B60L 55/00 - Dispositions relatives à la fourniture d'énergie emmagasinée dans un véhicule à un réseau électrique, c.-à-d. du véhicule au réseau [V2G]
• H01R 13/639 - Moyens additionnels pour maintenir ou verrouiller les pièces de couplage entre elles après l'engagement
• H02J 3/14 - Circuits pour réseaux principaux ou de distribution, à courant alternatif pour règler la tension dans des réseaux à courant alternatif par changement d'une caractéristique de la charge du réseau par interruption, ou mise en circuit, des charges du réseau, p. ex. charge équilibrée progressivement

Abrégé

The present disclosure describes an apparatus comprising a first set of inlet ports to connect with a vehicle charging station, the first set of inlet ports configured to receive first power from a vehicle charging station; a second set of inlet ports to connect with an external power source, the second set of inlet ports configured to receive second power from the external power source; a first set of outlet ports to supply the first power from the vehicle charging station to a first vehicle in a first configuration and the second power from the external power source to the first vehicle in a second configuration; and a second set of outlet ports to direct the first power from the vehicle charging station to a second apparatus in the second configuration, wherein the second apparatus is configured to supply the first power to a second vehicle.

Classes IPC  ?

• H02J 7/00 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries
• B60L 53/10 - Procédés de chargement de batteries spécialement adaptées aux véhicules électriquesStations de charge ou équipements de charge embarqués pour ces batteriesÉchange d'éléments d’emmagasinage d'énergie dans les véhicules électriques caractérisés par le transfert d’énergie entre la station de charge et le véhicule
• B60L 53/12 - Transfert d'énergie par induction
• B60L 53/14 - Transfert d'énergie par conduction
• B60L 53/16 - Connecteurs, p. ex. fiches ou prises, spécialement adaptés pour recharger des véhicules électriques
• B60L 53/60 - Surveillance et commande des stations de charge
• B60L 53/66 - Transfert de données entre les stations de charge et le véhicule
• B60L 53/67 - Commande de plusieurs stations de charge
• B60L 55/00 - Dispositions relatives à la fourniture d'énergie emmagasinée dans un véhicule à un réseau électrique, c.-à-d. du véhicule au réseau [V2G]
• H01R 13/639 - Moyens additionnels pour maintenir ou verrouiller les pièces de couplage entre elles après l'engagement
• H02J 3/14 - Circuits pour réseaux principaux ou de distribution, à courant alternatif pour règler la tension dans des réseaux à courant alternatif par changement d'une caractéristique de la charge du réseau par interruption, ou mise en circuit, des charges du réseau, p. ex. charge équilibrée progressivement

Produits et services

Leadership training program consisting of leadership training, mentoring and networking; educational and training services; providing of training; entertainment; sporting and cultural activities.

Abrégé

There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a dithiolsaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

Classes IPC  ?

• C07H 5/10 - Composés contenant des radicaux saccharide dans lesquels les liaisons carbone-oxygène ont été remplacées par le même nombre de liaisons carbone-hétéro-atomes à des atomes d'halogènes, d'azote, de soufre, de sélénium ou de tellure au soufre, au sélénium ou au tellure au soufre
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61P 11/12 - Mucolytiques

Abrégé

There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a dithiolsaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

Classes IPC  ?

• C07H 5/10 - Composés contenant des radicaux saccharide dans lesquels les liaisons carbone-oxygène ont été remplacées par le même nombre de liaisons carbone-hétéro-atomes à des atomes d'halogènes, d'azote, de soufre, de sélénium ou de tellure au soufre, au sélénium ou au tellure au soufre
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61P 11/12 - Mucolytiques

Abrégé

NicotianaNicotiana tabacum Nicotiana sylvestris Nicotiana sylvestris.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

A composition comprising BpPA26 is provided. The composition is for use in vaccine therapy to treat or prevent pathogenic Burkholderia species infection in a mammal, typically a human or an equine mammal. The species include Burkholderia cepacia complex, Burkholderia mallei, and Burkholderia pseudomallei.

Classes IPC  ?

• A61K 39/02 - Antigènes bactériens
• A61P 31/04 - Agents antibactériens
• C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries

Abrégé

A composition for cell culture, the composition comprising glycosaminoglycan (GAG) having a molecular weight of from 60 to 2000 kDa, wherein the GAG has a molecular weight distribution comprising two or more peaks. Use of the composition for enhancing or influencing ECM deposition in a cell culture; or as a macromolecular crowding agent in cell culture. A cell culture medium comprising the composition. A method of eukaryote cell culture; a method of enhancing or influencing ECM deposition in eukaryote cell culture; and a method of manufacturing a cell culture medium.

Classes IPC  ?

• C08L 5/08 - ChitineSulfate de chondroïtineAcide hyaluroniqueLeurs dérivés
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet

Abrégé

The present invention relates to a compound of Formula I, Li(ox)]2[MlmM2nM3k(OH)pFq; wherein M1, M2 and M3 are metals; and X is a halogen chosen from F, Cl and Br; and m, n and k are, independently, a number between 0 and 5, the sum of m, n and k is 5; p and q are, independently, a number between 0 and 8, and the sum of p and q is 8; and to uses thereof and methods of synthesis thereof.

Classes IPC  ?

• C01G 53/00 - Composés du nickel
• C01G 51/00 - Composés du cobalt
• C07C 51/41 - Préparation de sels d'acides carboxyliques par conversion de ces acides ou de leurs sels en sels ayant la même partie acide carboxylique
• C07F 15/06 - Composés du cobalt
• H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p. ex. LiNiO2, LiCoO2 ou LiCoOxFy

Abrégé

An optical element (100) comprises a substrate (110) and a conductive portion (120) configured to, upon application of an electrical current therethrough, generate heat through joule heating. The substrate is configured to receive heat generated in the conductive portion and, in response, undergo thermal expansion so as to change the curvature of a surface of the optical element. A method of changing the curvature of an optical element is also provided. The method comprises generating heat within the optical element so as to cause thermal expansion within the optical element.

Classes IPC  ?

• G02B 3/14 - Lentilles remplies d'un fluide ou à l'intérieur desquelles le vide a été fait à distance focale variable
• G02B 26/08 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la direction de la lumière

Abrégé

The present invention composition relates to compositions and combination therapies for use in the prevention, management, amelioration or treatment of a cancer or RASopathy disorders in which targeted therapy is used, the composition comprising two enzyme inhibitors targeting two different conformations of an enzyme, or enzymes in the same functional family, implicated in the cancer or RASopathy disorders. The present invention also relates to methods for identifying enzyme inhibitors which may be suitable for use in treatments.

Classes IPC  ?

• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
• A61K 31/4409 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 4, p. ex. isoniazide, iproniazide
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 35/00 - Agents anticancéreux

Abrégé

A microfluidic nucleic acid extraction chip (1), the chip (1) comprising a membrane-containing chamber (6) bonded between a first layer (2) and a second layer (3), wherein the first layer (2) comprises a sample inlet port (4) in fluid communication with the membrane-containing chamber (6) by a first microchannel (8), and a wash buffer inlet port (10) and an elution buffer waste collection port (12) in fluid communication with the membrane-containing chamber (6) by a second microchannel (14); wherein the second layer (3) comprises an elution buffer inlet port (5) in fluid communication with an eluate collection port (7) adapted to deliver extracted nucleic acid to a nucleic acid amplification module via a third microchannel (9); and wherein the membrane-containing chamber (6) is in fluid communication with the second layer (3) through an extraction microchannel (11); and the membrane-containing chamber (6) contains a silica membrane modified with a hyperbranched, cationic group.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]

Abrégé

A computer implemented method and system for dynamically recommending footwear size includes receiving a plurality of images of a foot of a user during a current scan of the user foot, analysing the plurality of images to generate a 3D foot profile of the user, determining a foot size of the user based on the 3D foot profile, predicting a foot growth pattern of the user based on the 3D foot profile, and a user profile, recommending one or more footwear size for the user based on the foot size, the predicted foot growth pattern, one or more footwear brands and models, and predicting a time of next scan of the foot based on the recommended footwear size and the predicted foot growth pattern.

Classes IPC  ?

• G06Q 30/0601 - Commerce électronique [e-commerce]

Abrégé

Disclosed is a computer-implemented method of dynamically compressing and scaling a base model during run-time, wherein the base model is a deep neural network containing a task-specific head and a backbone divided into a plurality of segments. The method includes providing a plurality of candidate early exit modules and corresponding plurality of candidate threshold values for each segment, heuristically searching a plurality of optimal early exit configurations for the base model, based on a plurality of combinations of accuracy and complexity with respect to the base model, wherein an early exit configuration enumerates which early exit module and what threshold value to be used at output of each segment, loading an optimal early exit configuration onto the base model during run-time, and running the backbone part of the base model segment by segment and ending the run-time at a segment when a confidence value of an output of corresponding early exit module exceeds corresponding threshold value.

Classes IPC  ?

• G06N 3/082 - Méthodes d'apprentissage modifiant l’architecture, p. ex. par ajout, suppression ou mise sous silence de nœuds ou de connexions
• G06N 3/045 - Combinaisons de réseaux
• G06N 3/0985 - Optimisation d’hyperparamètresMeta-apprentissageApprendre à apprendre
• G06N 3/096 - Apprentissage par transfert
• G06N 3/0464 - Réseaux convolutifs [CNN, ConvNet]

Abrégé

The invention relates to a serine protease inhibitor (Serpin) comprising a modified Reactive Centre Loop (RCL), wherein the modified RCL comprises a transmembrane serine protease 2 (TMPRSS2) inhibitory sequence having one or more amino acid substitutions at positions P4 to P1′. The invention also relates to a method of treating and/or preventing a condition in a subject in need thereof, where the TMPRSS2 activity is implicated in said condition, the method comprising administering the Serpin of the present invention.

Classes IPC  ?

• A61K 38/55 - Inhibiteurs de protéases
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07K 14/81 - Inhibiteurs de protéase

Abrégé

A method of performing hybrid electrochemical and abrasive fluid polishing is provided. The method comprised disposing (202) a workpiece to be polished and a cathode in a flow of polishing fluid, wherein the polishing fluid comprises at least one electrolyte and at least one abrasive medium. The method further comprises connecting (204) the workpiece and the cathode to an electrical power supply. An apparatus (100) is also provided for hybrid electrochemical and abrasive fluid polishing. The apparatus comprises a vessel (102) comprising an inlet (103a) and an outlet (103b) to allow a flow of fluid through the vessel. The apparatus further comprises one or more mounts (104) configured to hold a workpiece (108) to be polished in the vessel between the inlet and the outlet. The apparatus also comprises one or more connectors (106) configured to connect the workpiece and a cathode (110) to an electrical power supply.

Classes IPC  ?

• B23H 5/08 - Meulage électrolytique
• C09G 1/02 - Compositions de produits à polir contenant des abrasifs ou agents de polissage
• C25F 3/16 - Polissage
• C25F 7/00 - Éléments de construction des cellules, ou leur assemblage, pour l'enlèvement électrolytique de matières d'objetsEntretien ou conduite

Abrégé

A microfluidic chip (1,100) microfluidic chip (1,100) comprising at least two inlets (2, 4, 4a-4j) that meet at a junction (5, 5a, 5b) that is in fluid communication with a proximal end (3) of a channel (8, 8a, 8b, 8c) thereof and an outlet (6) that is in fluid communication with a distal end (7) of the channel (8), wherein the channel (8, 8a, 8b, 8c) comprises either a plurality of spaced-apart baffle structures (10) continuous with an inner wall (12) of the channel (8, 8a, 8b, 8c) or at least one aerofoil-shaped baffle structure (14), or a combination thereof, and forms a microchannel (9) in the channel (8, 8a, 8b, 8c) adapted to accommodate a fluid.

Classes IPC  ?

• B01F 23/41 - Émulsion
• B01F 25/431 - Tubes de mélange droits avec des chicanes ou des obstructions qui ne provoquent pas de chute de pression importanteChicanes à cet effet
• B01F 25/433 - Tubes de mélange dans lesquels la forme du tube influence le mélange, p. ex. tubes de mélange ayant une section transversale variable ou pourvus de profils s'étendant vers l'intérieur
• B01F 33/30 - Micromixeurs

Abrégé

The present invention relates to a system for measurement of peripheral aberration of the human eye. The system is characterized by a specially designed multifaced mirror having its each face distributed along an elliptical contour. The normal to any point on the elliptical contour bisects an angle formed by the point and the line connecting the two focal points of the elliptical contour. The length of the multifaced mirror is equal to the length of a line segment formed between the intersections of a plurality of tangents drawn at each intersection of the elliptical contour and a plurality of rays. The plurality of rays extends from a focal point at the centre of the entrance pupil to a plurality of other focal points at the centre of the entrance pupil. Each ray has a predetermined difference in gradient with respect to each other adjacent ray.

Classes IPC  ?

• A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
• A61B 3/00 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux

Abrégé

A molecular evaluation method for predicting the molecular mechanisms through which a perturbation promotes or inhibits a cellular transition from a first cell state to a second cell state. Cells are clustered in a multi-dimensional representation to identify distinct cell states, with dimensions corresponding to molecular features, which are ranked according to a vector component directed towards a separating hypersurface. Core network components are identified with the highest ranking and a reduced dimension space is used, without the core component dimensions, to assess the effects of perturbations in terms of a Dynamic Phenotype Descriptor (DPD) which represents the remainder of the global network on which the core network acts. Bayesian Modular Response Analysis is used to reconstruct the topology and signs and strengths of causal connections between nodes of the core network and the DPD. A resulting mechanistic model based on ordinary differential equations (ODE) is derived that calculates the quality and quantity of changes which are needed to convert one cell state into another permitting interventions to be identified that will promote or inhibit particular cell transitions.

Classes IPC  ?

• G16B 5/20 - Modèles probabilistes
• G16B 20/00 - TIC spécialement adaptées à la génomique ou protéomique fonctionnelle, p. ex. corrélations génotype-phénotype
• G16B 40/20 - Analyse de données supervisée

Abrégé

Disclosed is a system and method for assessing spectral residual viability (SRV) and corresponding remaining shelf life (RSL) of a food product, comprising capturing one or more images of the food product by a camera; analysing the one or more images to perform a visual assessment of a plurality of individual attributes of the food product, using respective plurality of vectoral algorithms; estimating a Quality Index (QI) of the food product based on an average summation of each individual analysis of each individual IE attribute; receiving a future storage temperature at which the food product is stored or transported; estimating a SRV and corresponding RSL of the food product based on the QI and the future storage temperature. The present invention provides a system and method that has the functional capability to merge both biologic product specific degradation models with user defined predicted consequence to predict SRV and corresponding RSL of the product.

Classes IPC  ?

• G06V 20/68 - Aliments, p. ex. fruits ou légumes
• G01N 33/02 - Nourriture
• G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
• G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes

Abrégé

The present invention provides a tear stimulation device and method for delivering thermal energy at controlled rates to stimulate the creation of a natural tear by activating the thermo-receptors on the sensory nerves of the eye and extended orbital region, modulation of the thermal energy resulting in controlled, repeated tearing to provide a naturally lubricated and nourishing environment in which the ocular surface can heal.

Classes IPC  ?

• A61F 7/00 - Appareils de chauffage ou de refroidissement pour traitement médical ou thérapeutique du corps humain

Abrégé

A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

Disclosed is a video summarisation method that includes converting an input video file to a video transcript using speech recognition, segmenting the video transcript into a plurality of paragraphs using a transformer based model, performing relevance ranking of the plurality of paragraphs by assigning a paragraph importance score to each paragraph, based on relevance of each paragraph to an overall content of the video transcript, creating a plurality of candidate summaries from the plurality of paragraphs, each candidate summary comprising two or more paragraphs, performing coherence reranking of the plurality of candidate summaries based on a combination of coherence and relevance of each candidate summary, and selecting a summary based on the coherence reranking.

Classes IPC  ?

• H04N 21/8549 - Création de résumés vidéo, p. ex. bande annonce
• G06F 40/40 - Traitement ou traduction du langage naturel
• G10L 15/26 - Systèmes de synthèse de texte à partir de la parole

Abrégé

An imaging device comprising: an electromagnetic radiation, EMR, source, configured to provide first EMR, preferably monochromatic EMR, having a first wavelength in a range from 0.1 μm to 3 μm, preferably in a range from 0.4 μm to 1.4 μm, more preferably in range from 0.75 μm to 0.85 μm, most preferably in range from 780 nm to 805 nm, for example about 785 nm; a set of flexible fibre-optic bundles, including a first fibre-optic bundle, having respective proximal ends and distal ends, wherein the proximal end of the first fibre-optic bundle is optically coupled to the EMR source and wherein the distal end of the first fibre-optic bundle is flexibly positionable and/or orientable to illuminate a target with the first EMR, incident thereupon, provided by the EMR source; and an EMR detector configured to detect second EMR, having a second wavelength in a range from 0.1 μm to 3 μm, preferably in a range from 0.4 μm to 1.4 μm, more preferably in range from 0.80 μm to 0.85 μm, most preferably in range from 810 nm to 830 nm, for example about 825 nm, emitted by the illuminated target and to output signals corresponding to the detected second EMR.

Classes IPC  ?

• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
• A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
• A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
• A61B 1/07 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement utilisant des moyens conduisant la lumière, p. ex. des fibres optiques

Abrégé

The present disclosure relates to a system and method for treating wastewater, the method comprising the steps of: providing a vessel for receiving wastewater and a gas, wherein the gas comprises one or more constituent gas components; directing the wastewater and a first gas component of the gas to the vessel; reducing the temperature of the contents of the vessel from a first temperature to a second temperature to facilitate the formation of clathrate hydrates comprising the wastewater and the first gas component; increasing the temperature of the contents of the vessel with respect to the second temperature to facilitate melting of the clathrate hydrates; and removing clean water and/or the first gas component from the vessel.

Classes IPC  ?

• B01F 33/05 - Mélangeurs utilisant des radiations, p. ex. des champs magnétiques ou des micro-ondes pour mélanger les matières
• B01D 53/14 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par absorption
• B01D 53/32 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par effets électriques autres que ceux prévus au groupe
• B01F 23/23 - Mélange de gaz avec des liquides en introduisant des gaz dans des milieux liquides, p. ex. pour produire des liquides aérés
• B01F 23/411 - Émulsion en utilisant des champs électriques ou magnétiques, de la chaleur ou des vibrations
• B01F 31/00 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants
• B01F 35/21 - Mesure
• B01F 35/92 - Systèmes de chauffage ou de refroidissement pour chauffer l'extérieur du récipient, p. ex. vestes chauffantes ou brûleurs
• C02F 1/22 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par congélation
• C02F 3/28 - Procédés de digestion anaérobies

Abrégé

The present invention relates to a host cell. The host cell finds utility as a biosensor by comprising at least one nucleic acid modification in the nucleic acid sequence of at least one gene. Also disclosed is the host cell for use as a biosensor, use of the host cell as a biosensor, a method of producing a biosensor, and a method of identifying the presence, absence or quantity of an analyte in a sample.

Classes IPC  ?

• C07K 14/245 - Escherichia (G)
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
• C12R 1/19 - Escherichia coli

Abrégé

A method and a generator for producing nanobubbles or nanodroplets at ambient conditions; the method comprising: providing a volume for accommodating a liquid; distributing a medium within the liquid, wherein the medium is provided to the volume at ambient conditions; generating an electric field using an electrode in the proximity of the volume for facilitating the generation of nanobubbles or nanodroplets; wherein the electrode and the liquid are not in direct electrical contact to prevent electrolysis occurring within the volume.

Classes IPC  ?

• B01F 23/23 - Mélange de gaz avec des liquides en introduisant des gaz dans des milieux liquides, p. ex. pour produire des liquides aérés
• B01D 53/14 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par absorption
• B01D 53/32 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par effets électriques autres que ceux prévus au groupe
• B01F 23/2375 - Mélange de gaz avec des liquides en introduisant des gaz dans des milieux liquides, p. ex. pour produire des liquides aérés caractérisé par les propriétés physiques ou chimiques des gaz ou des vapeurs introduits dans le milieu liquide pour obtenir des bulles fines, c.-à-d. des bulles d'une taille inférieure à 100 µm pour obtenir des bulles fines, c.-à-d. des bulles d'une taille inférieure à 1 µm
• B01F 33/05 - Mélangeurs utilisant des radiations, p. ex. des champs magnétiques ou des micro-ondes pour mélanger les matières
• B01F 35/21 - Mesure
• B01F 35/90 - Systèmes de chauffage ou de refroidissement
• C02F 1/22 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par congélation

Abrégé

A method of discriminating between a first tissue status and a second tissue status of an organ or a part thereof, the method implemented by a computer comprising a processor and a memory, the method comprising: obtaining a first time series of images, including a first image and a second image, of the organ, having a set of spatial regions including a first spatial region, having the first tissue status, and a second spatial region, during a first time period after a first perfusion of the organ with a first contrast agent and before controlling perfusion of the organ; generating a first set of intensity-time profiles of the set of spatial regions, including a first intensity-time profile of the first spatial region, using respective intensities of the set of spatial regions of the first time series of images; obtaining a second time series of images, including a first image and a second image, of the organ, during a second time period after a second perfusion of the organ with a second contrast agent and after controlling perfusion of the organ; generating a second set of intensity-time profiles of the set of spatial regions, including a first intensity-time profile of the first spatial region and a second intensity-time profile of the second spatial region, using respective intensities of the set of spatial regions of the second series of images; comparing the first set of intensity-time profiles and the second set of intensity-time profiles; and discriminating between the first spatial region and the second spatial region based on a result of comparing the first set of intensity-time profiles and the second set of intensity-time profiles.

Classes IPC  ?

• G06T 7/00 - Analyse d'image

Abrégé

The present invention is concerned with an endovascular occlusion device for use in occluding a lumen of the endovascular system to treat certain medical conditions such as vascular malformations, bleeding vessels or occluding vessels in order to induce tissue ischemia or necrosis, the occlusion device including a deformable sleeve displaceable between a collapsed state and an expanded state and a conical array of cantilevered arms extending from a distal end of the sleeve and converging towards distal tips such as to define a first haemostatic valve about the distal end of the sleeve. The distal end of the sleeve will be at least partially covered with a polymer fluid impermeable membrane in order to provide a seal to prevent fluid flow through the occlusion device. The internal valve will be haemostatic regardless of the initial direction of blood flow and will allow distal endovascular delivery of a surgical instrument such as a catheter that can be manipulated and used to deliver therapeutic agents such as liquid or small particle embolics.

Classes IPC  ?

• A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical

Abrégé

Protein agglomeration is inhibited in a protein-containing liquid, within an industrial processing plant, using a microwave resonance cavity having an inlet conduit and an outlet conduit. The liquid is transported into and out of the cavity, and while within the cavity, it is exposed to a microwave electromagnetic field. This field exposure reduces the tendency of proteins within the liquid to agglomerate, and inhibits coagulation or protein deposition for an extended period of time after leaving the cavity.

Classes IPC  ?

• A23C 3/07 - Conservation du lait ou de préparations à base de lait par irradiation, p.ex. par micro-ondes

Abrégé

Disclosed is a recurrent DVR model and a DVR based recurrent neural network for generating a non-linear output signal. The recurrent DVR model includes a magnitude recurrent filter that comprises a recurrent neural network for combining a magnitude of a current input signal with previous sequence information of the magnitude recurrent filter in a recurrent manner, to generate an intermediate output magnitude, a phase recurrent filter that comprises a recurrent neural network for combining a phase of a current input signal with previous sequence information of the phase recurrent filter in a recurrent manner, to generate an output phase, a DVR module for performing a DVR operation on the intermediate output magnitude to generate an output magnitude, and a multiplier for multiplying the output magnitude with cos and sine components of the output phase to generate cos and sine magnitude components of the non-linear output signal respectively.

Classes IPC  ?

• H03F 3/34 - Amplificateurs de courant continu dans lesquels tous les étages sont couplés en courant continu
• H03F 1/32 - Modifications des amplificateurs pour réduire la distorsion non linéaire
• H03F 3/24 - Amplificateurs de puissance, p. ex. amplificateurs de classe B, amplificateur de classe C d'étages transmetteurs de sortie
• H03F 1/02 - Modifications des amplificateurs pour augmenter leur rendement, p. ex. étages classe A à pente glissante, utilisation d'une oscillation auxiliaire
• H03F 1/00 - Détails des amplificateurs comportant comme éléments d'amplification uniquement des tubes à décharge, uniquement des dispositifs à semi-conducteurs ou uniquement des composants non spécifiés

Abrégé

A vaccine comprising one or more VTEC immunogens. The vaccine is for use in vaccine therapy to treat or prevent VTEC infection in a mammal and for use in vaccine therapy to treat or prevent HUS in a mammal. A method of diagnosing VTEC infection in a subject is also provided.

Classes IPC  ?

• A61K 39/ -
• A61P 1/ -

Abrégé

A surface preparation method (200) for a composite material (104) having an original surface (110), the material (104) comprising fibres (104a) within a matrix (104b), comprises removing (204) a surface portion of the matrix (104b) by plasma ablation so as to reveal and activate (206) a new surface (120) with at least a portion of a plurality of the fibres (104a) exposed thereon, without creating a residual heat-affected zone.

Classes IPC  ?

• H01J 37/02 - Tubes à décharge pourvus de moyens permettant l'introduction d'objets ou d'un matériau à exposer à la décharge, p. ex. pour y subir un examen ou un traitement Détails
• H01J 37/32 - Tubes à décharge en atmosphère gazeuse

Abrégé

A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles

Abrégé

An effective amount of a Saccharomyces cerevisiae-derived (1→3)-β-D-glucan particle for use in a method to program bone marrow hematopoietic stem and progenitor cells (HSPC) to promote multipotent progenitor (MPPs) expansion in favour of myelopoiesis in a subject.

Classes IPC  ?

• A61K 31/716 - Glucanes
• A61P 37/04 - Immunostimulants

Abrégé

The present invention relates to a cell, wherein the cell is modified to: reduce O-GalNAc galactosylation activity in the cell by reduction of functional COSMC molecular chaperone in the cell and/or by reduction of functional T-synthase in the cell; and overexpress β1,4-galactosyltransferase in the cell; and associated methods, kits and uses.

Classes IPC  ?

• C12P 21/00 - Préparation de peptides ou de protéines
• C12N 9/10 - Transférases (2.)
• C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux

Abrégé

A sensor device (300) comprises a direct or indirect light source (310). The sensor device further comprises a light angle sensor (320) configured to measure the angle and of incident light from the light source. The sensor device also comprises a deformable element (330) configured to support the light source at a position above the light angle sensor so as to direct light onto the light angle sensor. The device is configured to detect displacement of the light source and/or a reference point in or on the deformable element relative to the light angle sensor based, at least in part, on a change in the measured incident light angle produced by a deformation of the element that displaces the light source from a rest position.

Classes IPC  ?

• G01L 1/24 - Mesure des forces ou des contraintes, en général en mesurant les variations des propriétés optiques du matériau quand il est soumis à une contrainte, p. ex. par l'analyse des contraintes par photo-élasticité
• G01L 5/00 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques

Abrégé

A microneedle for transdermal drug delivery, the microneedle comprising an input channel extending through the microneedle along a longitudinal axis of the microneedle, the input channel defining a sidewall, a first end, and a second end, the input channel configured to receive fluid input into the microneedle. The microneedle comprises one or more outlet channels extending between an interior surface of the sidewall, and an exterior surface of the sidewall, such that each of the one or more outlet channels define a fluid path between the input channel and the exterior surface of the sidewall. The one or more outlet channels are angled relative to the longitudinal axis of the microneedle at an angle which is greater than 0˚ and less than 90˚.

Classes IPC  ?

• A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau

Abrégé

Provided are an apparatus and system for directing power flow between multiple devices, the apparatus comprising: one or more inlet ports for connection to one or more devices; a plurality of outlet ports configured for supplying electrical power; and a computing device configured to route power from the one or more inlet ports to the outlet ports. The system comprises a plurality of the apparatus connected to each other.

Classes IPC  ?

• H02J 7/00 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries
• B60L 53/12 - Transfert d'énergie par induction
• B60L 53/60 - Surveillance et commande des stations de charge
• B60L 53/67 - Commande de plusieurs stations de charge
• H01R 13/639 - Moyens additionnels pour maintenir ou verrouiller les pièces de couplage entre elles après l'engagement
• B60L 53/16 - Connecteurs, p. ex. fiches ou prises, spécialement adaptés pour recharger des véhicules électriques
• B60L 53/10 - Procédés de chargement de batteries spécialement adaptées aux véhicules électriquesStations de charge ou équipements de charge embarqués pour ces batteriesÉchange d'éléments d’emmagasinage d'énergie dans les véhicules électriques caractérisés par le transfert d’énergie entre la station de charge et le véhicule
• B60L 55/00 - Dispositions relatives à la fourniture d'énergie emmagasinée dans un véhicule à un réseau électrique, c.-à-d. du véhicule au réseau [V2G]
• B60L 53/66 - Transfert de données entre les stations de charge et le véhicule
• B60L 53/14 - Transfert d'énergie par conduction
• H02J 3/14 - Circuits pour réseaux principaux ou de distribution, à courant alternatif pour règler la tension dans des réseaux à courant alternatif par changement d'une caractéristique de la charge du réseau par interruption, ou mise en circuit, des charges du réseau, p. ex. charge équilibrée progressivement

Abrégé

Serious gaming for interrelated critical infrastructure (CI) resilience improvement includes receiving from a serious gaming participant a selection of an anomalous event for a geographic region for which a hierarchy of CI elements has been modeled, and a specified change in allocation of at least one resource in a corresponding one of the CI elements. A previously determined cascading impact upon the CI elements resulting from the anomalous event is then retrieved and compared to a hypothetical cascading impact produced by a simulation of the model with the specified change. A visualization of the comparison is transmitted to the serious gaming participant so as to show the result of the hypothetical change in resources upon the cascading impact of the event in the hierarchy of CI elements.

Classes IPC  ?

• G06Q 50/26 - Services gouvernementaux ou services publics

Abrégé

A heating system (1) for use with a 3D printer, the heating system (1) comprising an infrared heat source (20) that is configured to be proximal to a printhead (500) of the 3D printer, wherein the infrared heat source (20) is configured to (a) heat the material as it is extruded from the printhead (500) and deposited on a substrate, and to (b) apply heat in form of a heat footprint (22) to an area below the printhead (500), including the substrate and the deposited material, after the material is deposited and starts to cool.

Classes IPC  ?

• B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
• B29C 64/209 - TêtesBuses
• B29C 64/295 - Éléments de chauffage
• B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
• B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
• H05B 1/02 - Dispositions de commutation automatique spécialement adaptées aux appareils de chauffage
• H05B 3/40 - Éléments chauffants ayant la forme de tiges ou de tubes

Abrégé

A composition comprising a polymer and a salt of a pharmaceutical compound, wherein the salt is an ionic liquid is described. A solid dosage form comprising such a composition, and a method of preparing the composition are also described.

Classes IPC  ?

• A61K 31/4164 - 1,3-Diazoles
• A61K 31/37 - Coumarines, p. ex. psoralène
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 31/14 - Composés d'ammonium quaternaire, p. ex. édrophonium, choline

Abrégé

A process for producing a bio-based surfactant comprising an alkyl disulphate salt comprises the steps of methanolysis of medium chain length polyhydroxyalkanoic acid (mcl-PHA) to provide hydroxy fatty acid methyl ester monomers (HFAME's), reduction of the HFAME's to provide 1,3 alkyl diols, sulphation of the 1,3 alkyl diols to provide 1,3 alkyl disulphates, and neutralisation of the alkyl disulphates to provide a bio-based surfactant comprising 1,3 alkyl disulphate salt. A bio-based surfactant comprising a mixture of medium chain length 1,3 alkyl disulphate salts is also described.

Classes IPC  ?

• A61K 8/46 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du soufre
• A61Q 5/02 - Préparations pour le lavage des cheveux
• A61Q 11/00 - Préparations pour le nettoyage des dents, de la bouche ou des prothèses dentaires, p. ex. dentifricesBains de bouche
• A61Q 19/10 - Préparations pour le nettoyage ou le bain
• C07C 303/24 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides d'esters d'acides sulfuriques
• C11D 1/16 - Esters des acides sulfoniques ou de l'acide sulfuriqueLeurs sels dérivés d'alcools divalents ou polyvalents
• C12P 7/6409 - Acides gras

Abrégé

Embodiments of the present invention provide a method, system and computer program product for tiered data sharing privacy assurance in responding for requests to inspect investigative data. In an embodiment of the invention, a method for tiered data sharing privacy assurance in responding for requests to inspect investigative data includes receiving a request to access investigative data and applying a privacy test to the request to determine if the request is specific for an individual or generic to any individual. On condition that the privacy test is determined to be generic, the request may be denied. But otherwise, on condition the test is determined to be specific, a data sharing rule that defines a degree to which the investigative data is to be shared may be applied and the request responded to according to the defined degree.

Classes IPC  ?

• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p. ex. par clés ou règles de contrôle de l’accès

Abrégé

A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: NTF ⁡ ( z ) = Az - Q ( 1 + ∑ i = 1 K c i ⁢ z - i ) A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: NTF ⁡ ( z ) = Az - Q ( 1 + ∑ i = 1 K c i ⁢ z - i ) where A, Q and K are constants, coefficients ci are real valued and cK≠0 and wherein at least one of the zeroes zj of A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: NTF ⁡ ( z ) = Az - Q ( 1 + ∑ i = 1 K c i ⁢ z - i ) where A, Q and K are constants, coefficients ci are real valued and cK≠0 and wherein at least one of the zeroes zj of ( 1 + ∑ i = 1 K c i ⁢ z - i ) A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: NTF ⁡ ( z ) = Az - Q ( 1 + ∑ i = 1 K c i ⁢ z - i ) where A, Q and K are constants, coefficients ci are real valued and cK≠0 and wherein at least one of the zeroes zj of ( 1 + ∑ i = 1 K c i ⁢ z - i ) satisfies zj≠+1 for j=1, 2, . . . , K

Classes IPC  ?

• H03M 3/00 - Conversion de valeurs analogiques en, ou à partir d'une modulation différentielle

Abrégé

A device (1) is provided for controlling transmission of electromagnetic radiation through a transparent substrate. The device comprises a first plurality of electrodes (5a, 5b) arranged as a first layer (2) and a second plurality of electrodes (8a, 8b) arranged as a second layer (4) spaced apart from the first layer. A carrier material (6) is located between the first plurality of electrodes and the second plurality of electrodes comprising a plurality of molecules (10) configured to change their orientation in the presence of an electric field thereby to alter the transmission of electromagnetic radiation through the device. The first plurality of electrodes and the second plurality of electrodes are configured to generate an electric field in the carrier material upon application of a potential difference between the first and second plurality of electrodes, to alter the transmission of electromagnetic radiation through the device.

Classes IPC  ?

• G02F 1/169 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des particules orientables non sphériques ayant une caractéristique optique commune, p. ex. des particules suspendues de copeaux de métal réfléchissant
• G02F 1/17 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments à absorption variable non prévus dans les groupes
• G02F 1/19 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments à réflexion ou réfraction variable non prévus dans les groupes
• E06B 9/24 - Écrans ou autres dispositifs protecteurs contre la lumière, notamment contre la lumière solaireÉcrans similaires pour protection de l'intimité ou pour des raisons esthétiques

Abrégé

A window system for controlling the transmission of thermal radiation from an external source of electromagnetic radiation comprises a windowpane (101, 103) comprising a transparent substrate, a first electrode layer (2) and a second electrode layer (4). A carrier material (6) is located between the first and second electrode layers comprising a plurality of molecules (10) orientable in the presence of an electric field. A processor (503) is configured to determine a position of an external source of electromagnetic radiation, calculate a direction of incidence of the electromagnetic radiation, determine electrodes in the first and second electrode layer to apply a potential difference between, and apply a potential difference between the determined electrode in the first electrode layer and the determined electrode in the second electrode layer.

Classes IPC  ?

• G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur
• E06B 3/67 - Blocs comprenant plusieurs panneaux de verre ou analogues qui sont espacés et fixés les uns aux autres de façon permanente, p. ex. le long des bords caractérisés par des aménagements ou des dispositifs additionnels pour l'isolation thermique ou acoustique
• G02F 1/13 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des cristaux liquides, p. ex. cellules d'affichage individuelles à cristaux liquides

Abrégé

Disclosed is a method of pruning an artificial neural network (ANN) that includes recording activations of the ANN on an input dataset that includes a plurality of data inputs of a plurality of classes, scoring each neuron of the ANN based on a class-separation ability of a neuron in corresponding activations, and pruning the one or more neurons based on the scoring. The scoring of a neuron comprises computing a plurality of activation scores of a neuron for corresponding plurality of data inputs for each class, calculating a class centre of the neuron based on an average value of the plurality of activation scores for said class for each class, calculating a set of Euclidean distances for the neuron, for corresponding sets of class pairs, wherein a Euclidean distance is distance between class centres of corresponding pair, and calculating a class-separation score of the neuron, wherein the class-separation score is a median value of the plurality of Euclidean distances.

Classes IPC  ?

• G06N 3/08 - Méthodes d'apprentissage
• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 3/0464 - Réseaux convolutifs [CNN, ConvNet]

Abrégé

wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: j of j≠+1 for j=1, 2, . . . , K.

Classes IPC  ?

• H03M 7/32 - Conversion en, ou à partir d'une modulation delta, c.-à-d. une modulation différentielle à un bit
• H03M 7/36 - Conversion en, ou à partir d'une modulation différentielle à plusieurs bits, c.-à-d. la différence entre des échantillons successifs étant codée par plus d'un bit

Abrégé

The present invention relates to a compound of Formula I, Li(ox)]2[M1mM2nM3k(OH)pFq; wherein M1, M2 and M3 are metals; and X is a halogen chosen from F, Cl and Br; and m, n and k are, independently, a number between 0 and 5, the sum of m, n and k is 5; p and q are, independently, a number between 0 and 8, and the sum of p and q is 8; and to uses thereof and methods of synthesis thereof.

Classes IPC  ?

• C07F 15/06 - Composés du cobalt
• H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
• C07C 53/00 - Composés saturés ne comportant qu'un groupe carboxyle lié à un atome de carbone acyclique ou à un atome d'hydrogène
• C07C 55/06 - Acide oxalique
• C01G 51/00 - Composés du cobalt
• C01G 53/00 - Composés du nickel

Abrégé

Disclosed herein, inter alia, are methods of using thiosaccharide compounds for treating coronavirus infection.

Classes IPC  ?

• A61K 31/7016 - Disaccharides, p. ex. lactose, lactulose
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]

Abrégé

The present invention relates to a method of diagnosing and/or prognosing preeclampsia. Specifically, the method involves determining the quantitative level of one or more biomarkers in a biological sample from the subject and either diagnosing preeclampsia; prognosing unstable moderate early-onset preeclampsia; and/or diagnosing preeclampsia and prognosing unstable moderate early-onset preeclampsia in the subject.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present invention relates to proteins and protein libraries particularly for use in methods of screening to identify novel binding partners including diagnostic and therapeutic molecules.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Produits et services

Promoting and raising public awareness of the importance of the bioeconomy and the production, utilization and conservation of biological resources; promoting and raising public awareness of the importance of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering and research in the foregoing areas; promoting and raising public awareness of the use of biotechnology in the production of bio-based goods and services from biological material; administrative services, namely, organising and administering grant applications; administrative services, namely, administering peer review of research proposals; administrative services, namely, organising and administering grant schemes, and research programmes in respect of which grants have been made; administrative services, namely, organising and administering research and educational programmes in the field of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering; administrative services, namely, administration and management of research grants; administrative services, namely, management of grant funding for research programs in respect of which grants have been made; administrative services, namely, management of grant funding for the research and educational programs of others in the field of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering; business consultancy and advisory services. Providing grants, awards and other financial sponsorship in the fields of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering and research in the foregoing areas; raising funds for research in the fields of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering and research in the foregoing areas; provision of finance and grant aid; funding and investment in relation to research and development; financial assistance and financial aid in research development projects; providing financial grant applications; assessing proposals for research projects for the purpose of making financial grants; providing funding for symposia, seminars and courses of instruction related to environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering subject matter and intellectual property. Treatment and conversion of organic materials; Treatment and conversion of organic materials into energy sources using biological processes and agents; Conversion of plant and animal waste into energy sources; Conversion of plant and animal waste into useable products; waste treatment (conversion); treatment, transformation, recycling and recovery of wastes and bioresources; consultancy in the field of energy production. Education; Education services relating to the bioeconomy and the production, utilization and conservation of biological resources; Education and training relating to nature conservation and the environment; Education in the fields of environmental conservation, bioconversion, science, technology, innovation and engineering; educational services, namely, assessing proposals for research projects and ongoing assessments and review of research projects; provision of training in the field of environmental conservation, bioconversion, science, technology, innovation and engineering; arranging and conducting workshops in respect of research techniques and in the fields of environmental conservation, bioconversion, science, technology, innovation and engineering generally; symposia, seminars and courses of instruction related to scientific subject matter, intellectual property and/or the importance of environmental conservation, science, technology, innovation and engineering generally; publication of books, newspapers, magazines, pamphlets, periodicals and other printed matter, texts and databases in the fields of environmental conservation, bioconversion, science, technology, innovation and engineering; issuing of awards and conducting award ceremonies in the field of environmental conservation, bioconversion, science, technology, innovation and engineering; providing peer review of educational research proposals; providing assessment of educational research projects. Providing assistance and aid in the nature of expert advice and recommendations to Governmental and regulatory organisations in relation to research and development projects; providing peer review in the field of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering; providing a database of information relating to environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering in the nature of descriptions of funded projects and reports of progress made on funded projects; providing ongoing review and assessments of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering research projects; Research in the field of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering; Professional consultancy relating to the conservation of energy; consultancy in the field of energy-saving and energy use; agricultural research services; laboratory services. Agricultural, horticulture and forestry services; Providing information about agriculture, horticulture, and forestry services; Consultancy and advisory services relating to agriculture, horticulture and forestry; agricultural services relating to environmental conservation.

Abrégé

The present invention relates to a method for multivariate spatial data analysis of agricultural fields to provide actionable insights into spatial variability. The method is based on the spatial and temporal correlations of multiple localised parameters. The method comprises the step of combining a historical yield frequency map of a spatially contiguous set of regions with two or more Normalized Difference Vegetation Index (NDVI) maps of the regions from an ongoing cropping season, using multivariate geostatistical techniques such as Geographically Weighted Regression (GWR) model, wherein the latest captured NDVI map is the response variable, and the NDVI maps captured prior to the latest captured NDVI maps and the historical yield frequency map are the explanatory variables. Based on the parameter surface for each explanatory variable for the entire field, regions of interest such as under/over performance or variable performance can be identified. The method further provides a mean of automatically identifying the relative local weightings of each conflated data layer in relation to yield at each point across a field.

Classes IPC  ?

• G06V 20/13 - Images satellite
• G06V 20/10 - Scènes terrestres
• G06T 7/00 - Analyse d'image

Abrégé

A computer implemented method and system for dynamically recommending footwear size includes receiving a plurality of images of a foot of a user during a current scan of the user foot, analysing the plurality of images to generate a 3D foot profile of the user, determining a foot size of the user based on the 3D foot profile, predicting a foot growth pattern of the user based on the 3D foot profile, and a user profile, recommending one or more footwear size for the user based on the foot size, the predicted foot growth pattern, one or more footwear brands and models, and predicting a time of next scan of the foot based on the recommended footwear size and the predicted foot growth pattern.

Classes IPC  ?

• A43D 1/02 - Dispositifs de mesure du pied
• G06Q 30/06 - Transactions d’achat, de vente ou de crédit-bail

Abrégé

The present disclosure relates to a phase-locked loop (PLL) based on a charge-sharing locking technique, capable of both fractional-N and integer-N operation. The PLL comprises a voltage pre-setting stage; an oscillator: a shared capacitive load; and a switching network configured for selectively connecting the voltage pre-setting stage to the shared capacitive load during a voltage pre-setting stage for applying an expectant voltage to the capacitive load. The switching network is being further configured for selectively connecting the capacitive load to the oscillator during a charge-sharing locking stage for correcting a phase error in response to a difference between the expected voltage of the capacitor and the voltage of the oscillator. Frequency-tracking and waveform-learning stages are also provided for maintaining PVT (process, voltage, temperature) robustness and for suppressing fractional-N spur, respectively.

Classes IPC  ?

• H03L 7/099 - Détails de la boucle verrouillée en phase concernant principalement l'oscillateur commandé de la boucle
• H03L 7/04 - Commande automatique de fréquence ou de phaseSynchronisation utilisant un discriminateur de fréquence comportant un élément passif déterminant la fréquence dans lequel l'élément déterminant la fréquence comporte des inductances et des capacités réparties
• H03L 7/085 - Détails de la boucle verrouillée en phase concernant principalement l'agencement de détection de phase ou de fréquence, y compris le filtrage ou l'amplification de son signal de sortie

Abrégé

A clinical decision support system and method provides a practitioner with an indication of individual specific prospective usefulness of a referral. The practitioner is provided with individual-specific indication of prospective usefulness of findings for a referral, wherein comparative and statistical input data is supplemented by nuanced data to predict the usefulness of findings from optional and/or select subsequent diagnostic tests relative to individual specific propensity for a condition/disease.

Classes IPC  ?

• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne

Abrégé

The invention relates to a method of determining the likelihood of an individual transitioning to a first episode of psychosis (FEP), the method comprising determining the level of selected markers in a bodily fluid sample from the individual, wherein the increase or decrease in the markers is predictive of the individual transitioning to a first episode of psychosis (FEP). The invention also relates to a method of predicting the functional outcome for an individual following a first episode of psychosis (FEP), the method comprising determining the level of selected markers in a bodily fluid sample from the individual, wherein the increase or decrease in the markers is predictive of an increased risk of functional disability outcome for the individual.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present invention relates to a system for measurement of peripheral aberration of the human eye. The system is characterized by a specially designed multifaced mirror having its each face distributed along an elliptical contour. The normal to any point on the elliptical contour bisects an angle formed by the point and the line connecting the two focal points of the elliptical contour. The length of the multifaced mirror is equal to the length of a line segment formed between the intersections of a plurality of tangents drawn at each intersection of the elliptical contour and a plurality of rays. The plurality of rays extends from a focal point at the centre of the entrance pupil to a plurality of other focal points at the centre of the entrance pupil. Each ray has a predetermined difference in gradient with respect to each other adjacent ray.

Classes IPC  ?

• A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
• A61B 3/103 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour la détermination de la réfraction, p. ex. réfractomètres, skiascopes
• A61B 3/14 - Dispositions spécialement adaptées à la photographie de l'œil

Abrégé

38 ABSTRACT REMOTE MONITORING OF RESPIRATION 5 A computer-implemented method is provided for characterising breathing audio data. The method/system comprises acquiring breathing audio data. The method/system further comprises determining an estimated respiration rate based on the breathing audio data. The method/system also comprises identifying exhales in the breathing audio data using the estimated respiration rate. One or more computer-readable storage media are10 also provided comprising instructions that, when executed by a computer, cause the computer to determine an estimated respiration rate based on breathing audio data, and identify exhales in the breathing audio data using the estimated respiration rate. [To be accompanied, when published, by Figure 1 of the drawings.]15

Classes IPC  ?

• A61B 7/00 - Instruments d'auscultation
• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires

Abrégé

Hyperbranched cationic polymers are described. The polymers employ a 4-branching monomer resulting in an increase in the number of functional terminal groups due to the extra branching units, providing excellent transfection efficiency and cytocompatibility in different cell types, including aADSC, HeLa, Neu7 and RDEB keratinocytes, and delivering different genetic therapy approaches such GFP plasmid DNA and a ribonucleoprotein CRISP-Cas 9 complex for COL7A1 exon 80 skipping. In addition, the extra branching units of the polymer of the invention increases the positive charge on the polymer, which provides for improved endosomal escape within the cell. The 4-branching unit can be a diamine component, or a tetraacrylate component, although other 4-branching monomers may be employed such as for example any component with tetra acrylamide groups (i.e. 4-arm PEG acrylamide, 4-arm PEG maleimide), any component with tetra N- hydroxysuccinimide (NHS) groups (i.e. 4-arm PEG-succinimidyl carbonate NHS ester), any type of tetrathiol component (i.e. Pentaerythritol tetrakis(3-mercaptopropionate), 4-arm PEG-thiol, Tetra(2- mercaptoethyl)silane), and any tetraepoxy component (i.e. TetraGlycidyl methylenedianiline, Tetraglycidyl 1, 1′-methylenebis(naphthalene-2,7-diol), Pentaerythritol tetraglycidyl ether, 4-arm peg epoxide).

Classes IPC  ?

• C08G 73/02 - Polyamines
• C08G 63/685 - Polyesters contenant des atomes autres que le carbone, l'hydrogène et l'oxygène contenant de l'azote
• C08G 83/00 - Composés macromoléculaires non prévus dans les groupes
• C12N 15/87 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation

Abrégé

A method of performing hybrid electrochemical and abrasive fluid polishing is provided. The method comprised disposing (202) a workpiece to be polished and a cathode in a flow of polishing fluid, wherein the polishing fluid comprises at least one electrolyte and at least one abrasive medium. The method further comprises connecting (204) the workpiece and the cathode to an electrical power supply. An apparatus (100) is also provided for hybrid electrochemical and abrasive fluid polishing. The apparatus comprises a vessel (102) comprising an inlet (103a) and an outlet (103b) to allow a flow of fluid through the vessel. The apparatus further comprises one or more mounts (104) configured to hold a workpiece (108) to be polished in the vessel between the inlet and the outlet. The apparatus also comprises one or more connectors (106) configured to connect the workpiece and a cathode (110) to an electrical power supply.

Classes IPC  ?

• C25F 3/16 - Polissage
• B23H 5/08 - Meulage électrolytique
• C25F 3/24 - Polissage des métaux lourds du fer ou de l'acier
• C25F 3/26 - Polissage des métaux lourds des métaux réfractaires
• H01L 21/321 - Post-traitement

Abrégé

A continuous liquid-liquid phase separator (100) comprising a porous insert (101) housed concentrically within a non-permeable outer tube (102), the outer tube (102) having an inside surface (103), and wherein the configuration of the outer tube (102) and porous insert (101) form an annular gap (104) therebetween.

Classes IPC  ?

• B01D 63/06 - Modules à membranes tubulaires
• B01D 71/36 - Polytétrafluoro-éthylène

Abrégé

A molecular evaluation method for predicting the molecular mechanisms through which a perturbation promotes or inhibits a cellular transition from a first cell state to a second cell state. Cells are clustered in a multi-dimensional representation to identify distinct cell states, with dimensions corresponding to molecular features, which are ranked according to a vector component directed towards a separating hypersurface. Core network components are identified with the highest ranking and a reduced dimension space is used, without the core component dimensions, to assess the effects of perturbations in terms of a Dynamic Phenotype Descriptor (DPD) which represents the remainder of the global network on which the core network acts. Bayesian Modular Response Analysis is used to reconstruct the topology and signs and strengths of causal connections between nodes of the core network and the DPD. A resulting mechanistic model based on ordinary differential equations (ODE) is derived that calculates the quality and quantity of changes which are needed to convert one cell state into another permitting interventions to be identified that will promote or inhibit particular cell transitions.

Classes IPC  ?

• G16B 5/10 - Modèles booléens
• G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs

Abrégé

The present invention provides a tear stimulation device and method for delivering thermal energy at controlled rates to stimulate the creation of a natural tear by activating the thermo-receptors on the sensory nerves of the eye and extended orbital region, modulation of the thermal energy resulting in controlled, repeated tearing to provide a naturally lubricated and nourishing environment in which the ocular surface can heal.

Classes IPC  ?

• A61F 7/00 - Appareils de chauffage ou de refroidissement pour traitement médical ou thérapeutique du corps humain
• A61F 7/02 - Compresses ou cataplasmes procurant de la chaleur ou du froid

Abrégé

Mycobacterium tuberculosisMycobacterium bovis (M. bovis)Mycobacterium bovis (M. bovis) and other intracellular mycobacterial pathogens. In particular the invention relates to a panel of biomarkers which indicate increased gene expression that is indicative of tuberculosis infection in a subject. Suitably such a panel may allow advantageous characterisation of an infection status of a subject, for example an animal, for example cattle.

Classes IPC  ?

• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries

Abrégé

A lung perfusion solution comprises a base solution comprising a physiological mixture of electrolytes and buffers, 3.5-5.5% (w/v) a first macromolecule having a molecular weight of 40-100 KDa, and an amount of a second, high molecular weight, macromolecule sufficient to adjust the relative viscosity of the solution to 2.0-3.0.

Classes IPC  ?

• A01N 1/165 - Procédés liés à la pression, p. ex. en suivant une courbe de pression prédéfinie dans le temps
• A01N 1/126 - Agents physiologiquement actifs, p. ex. antioxydants ou nutriments
• A01N 1/143 - Appareils pour la perfusion d'organes

Abrégé

The present invention provides a tissue anchor and a system and method employing same, the anchors including a body having a first section and a second section reversibly engagable with one another, each section including a plurality of barbs in the form of microneedles projecting from the underside therefore, the barbs on one section being inclined towards barbs on the other section, such that tissue may be captured and deformed between the barbs through displacement of the first section relative to the second section in order to achieve robust retention of the tissue anchor at a deployment site.

Classes IPC  ?

• A61B 17/064 - Agrafes chirurgicales
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour la suture des plaiesSupports ou emballages pour aiguilles ou matériaux de suture
• A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau

Abrégé

A nanoparticulate composition comprises a gene editing ribonucleoprotein system complexed within a cationic polymer. The cationic polymer may be a Poly-beta amino ester hyperbranched polymer, especially a 4-branching hyperbranched polymer. The gene editing ribonucleoprotein system may be a CRISPR-Cas9 gene editing system configured to excise a mutation or exon in a gene, replace a mutation in a gene, or produce a knock-down or knock-out of a gene, and in particular configured to excise exon 80 of the COL7A1 gene which codes for the collagen VII protein. Data shows that using

Classes IPC  ?

• C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
• A61K 9/51 - Nanocapsules

Abrégé

Cannabis sativaCannabis sativaCannabis sativa plant is grown under continuous light conditions; providing a flower induction, pollination and seed setting period during which the plant is grown under short-day conditions; and providing a seed-ripening period during which the plant is grown under continuous light and water stress conditions. The vegetative growth period is a period of from 10 to 30 days and the flower induction, pollination and seed-setting period is a period of from 21 to 35 days.

Classes IPC  ?

• A01G 7/00 - Botanique en général
• A01G 22/00 - Culture de plantes spécifiques non prévue ailleurs

Abrégé

The invention provides a method of preparing a silica-protein sub-micron particle, the method comprising contacting, in an aqueous medium having a pH in the range of about 7.5 to 10 and having an ionic strength in the range of about 1.2 to 60 mM, (i) protein sub-micron particle cores comprising 0.2 to 3 μmoles, per mg of the protein sub-micron particle cores, of a basic compound of formula (I) or an ester and/or amide thereof wherein n is an integer selected from 1 to 10, and p is an integer selected from 1 to 3, with (ii) orthosilicic acid or an ester thereof, in an amount equivalent to 5 to 60% (w/w) orthosilicic acid per mg of the protein sub-micron particle cores, to form the silica-protein sub-micron particle. The invention also provides a method of making a GLP-1 receptor agonist sub-micron particle core, by a. contacting a peptide in an aqueous medium at a pH of about 5.0-8.0 and comprising about 0.3-1.3 mM peptide, wherein the peptide is a GLP-1 receptor agonist, with the above-mentioned basic compound of formula (I) or an ester and/or amide thereof: wherein n is an integer selected from 1 to 10, and p is an integer selected from 1 to 3; in a molar ratio between the peptide and the basic compound of from 1:about 20 to 1:about 90 to form a step a. reaction mixture having a pH of about 7.5 to 10.0; optionally about 9.5; b. contacting the step a. reaction mixture with zinc to form a step b. reaction mixture, wherein the ratio of peptide:basic compound:zinc in the step b. reaction mixture is 1:about 20 to 110:9 to 30; whereby the GLP-1 receptor agonist sub-micron particle core is formed. The invention also provides a method of making an insulin sub-micron particle core, the method comprising the steps of: a. contacting insulin in an aqueous medium having a pH of less than about 6.0 and comprising about 0.50 to about 1.50 mg/mL insulin, with the aforementioned basic compound of formula (I) or an ester and/or amide thereof; in a molar ratio between the insulin and the basic compound of from about 1:40 to about 1:140 to form a step a. reaction mixture having a pH of about 7.5 to 10; b. contacting the step a. reaction mixture with zinc to form a step b. reaction mixture, wherein the molar ratio of insulin:zinc in the step b. reaction mixture is 1:about 0.5 to about 10; whereby the insulin sub-micron particle core is formed.

Classes IPC  ?

• A61K 38/28 - Insulines
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 38/26 - Glucagons
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques

Abrégé

An imaging apparatus for imaging a sample (7) comprises an array of electronically addressable pixels (6) wherein each pixel is arranged to support a surface plasmon resonance therein to generate an evanescent electromagnetic field. This field extends transversely from the pixel so as to be salient from the array at a first side of the array for illuminating the sample at said first side. A light source (15) is arranged to illuminate the array with excitation light therewith to generate said surface plasmon resonance. An optical detector (12A, 12B, 12C) is arranged at a second side of the array which is opposite to said first side of the array for detecting optical radiation returned from the array in response to illumination of the array by said excitation light. A processing unit (4) is arranged to associate the detected optical radiation with the address of the pixel or pixels within the array at which the surface plasmon resonance was generated.

Classes IPC  ?

• G01N 21/552 - Réflexion totale atténuée
• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
• G01N 21/64 - FluorescencePhosphorescence

Abrégé

Disclosed herein is a method of treating a substance use disorder in a subject suffering from sustained substance exposure, comprising: administering to the subject a therapeutically effective amount of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), or a pharmaceutically acceptable derivative or salt thereof.

Classes IPC  ?

• A61K 31/4045 - Indole-alkylaminesLeurs amides, p. ex. sérotonine, mélatonine
• A61K 31/436 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'oxygène comme hétéro-atome du cycle, p. ex. rapamycine
• A61K 31/438 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle étant condensé en spiro avec des systèmes carbocycliques ou hétérocycliques
• A61K 31/4535 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un hétérocycle avec le soufre comme hétéro-atome du cycle, p. ex. pizotifène
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
• A61P 25/30 - Médicaments pour le traitement des troubles du système nerveux des états d'abus ou de dépendance
• A61P 39/02 - Antidotes

Abrégé

A method (100) of determining the temporal occurrences of one or more events characterising movement of a person is provided. The method comprises processing (102) kinematic data relating to movement of the person to determine the temporal occurrences of the events. The processing of the kinematic data comprises processing the kinematic data using the Teager-Kaiser energy operator. A system for measuring the temporal occurrences of one or more events characterising movement of a person is also provided.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre

Abrégé

The present application relates to a surgical delivery device (10) suitable for submucosal dye delivery or for introduction or extraction of fluidic or gaseous material into or from tissue (T), the surgical delivery device comprising an elongate main body (12) defining an evacuatable chamber (18) internally thereof, a lateral window (20) in the body in communication with the chamber and a guideway (24a) extending through the body and into the chamber.

Classes IPC  ?

• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
• A61B 17/34 - TrocartsAiguilles à ponction
• A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures

Abrégé

Protein agglomeration is inhibited in a protein-containing liquid, within an industrial processing plant, using a microwave resonance cavity having an inlet conduit and an outlet conduit. The liquid is transported into and out of the cavity, and while within the cavity, it is exposed to a microwave electromagnetic field. This field exposure reduces the tendency of proteins within the liquid to agglomerate, and inhibits coagulation or protein deposition for an extended period of time after leaving the cavity.

Classes IPC  ?

• A23C 3/07 - Conservation du lait ou de préparations à base de lait par irradiation, p.ex. par micro-ondes
• A23L 3/01 - Conservation des aliments ou produits alimentaires, en général, p.ex. pasteurisation ou stérilisation, spécialement adaptée aux aliments ou produits alimentaires par chauffage au moyen d'irradiation ou d'un traitement électrique au moyen de micro-ondes ou par chauffage diélectrique

Abrégé

Computer implemented methods for calculating configurational energy of a system with periodic boundary conditions having a plurality of particles are described. In an embodiment the method comprises steps of defining a cut-off radius defining a non-electrostatic interaction potential cut-off distance between particles in the system; defining a set of cell vectors to generate a simulation cell; defining a set of supercell vectors to generate a supercell that comprises a plurality of replicas of the simulation cell; calculating, for each particle located within the supercell, non-electrostatic pair potentials between the particle and any and all additional particles surrounding the particle within the cut-off radius, said non-electrostatic pair potentials resulting from the interaction of the particle with any and all other particles located within the cut-off radius; and summing all distinct non-electrostatic pair potentials to provide a non-electrostatic configurational energy of the system.

Classes IPC  ?

• G16C 20/30 - Prévision des propriétés des composés, des compositions ou des mélanges chimiques
• G16C 20/50 - Conception moléculaire, p. ex. de médicaments
• G06F 30/20 - Optimisation, vérification ou simulation de l’objet conçu

Abrégé

A broadband power amplifier circuit is disclosed for providing load modulation, and includes an active element for receiving an impedance matched signal and for amplifying the impedance matched signal to supply an amplified signal, and an output matching network having a load impedance and coupled to the active element for receiving the amplified signal, the output matching network matches the load impedance to an optimum load impedance of the active element.

Classes IPC  ?

• H03F 1/56 - Modifications des impédances d'entrée ou de sortie, non prévues ailleurs
• H03F 1/02 - Modifications des amplificateurs pour augmenter leur rendement, p. ex. étages classe A à pente glissante, utilisation d'une oscillation auxiliaire
• H03F 3/24 - Amplificateurs de puissance, p. ex. amplificateurs de classe B, amplificateur de classe C d'étages transmetteurs de sortie
• H03F 3/68 - Combinaisons d'amplificateurs, p. ex. amplificateurs à plusieurs voies pour stéréophonie

Abrégé

A whole (1→3)-β-D-glucan particle for treating or preventing a hepatic metabolic condition associated with obesity or diabetes in a subject is provided. The method comprises administering an effective amount of a whole (1→3)-β-D-glucan particle to said subject. The glucan is β-1,6 branched β-1,3 glucan.

Classes IPC  ?

• A61K 31/716 - Glucanes
• A23L 33/14 - Levures ou leurs dérivés
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques

Abrégé

A composition comprising a polymer and a salt of a pharmaceutical compound, wherein the salt is an ionic liquid is described. A solid dosage form comprising such a composition, and a method of preparing the composition are also described.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 31/138 - Aryloxyalkylamines, p. ex. propranolol, tamoxifène, phénoxybenzamine
• A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
• A61K 31/37 - Coumarines, p. ex. psoralène
• C07D 311/56 - Benzo [b] pyrannes non hydrogénés dans le carbocycle avec des atomes d'oxygène ou de soufre en positions 2 et 4 sans atome d'hydrogène en position 3

Abrégé

The present invention relates to a cell, wherein the cell is modified to: reduce O-GalNAc galactosylation activity in the cell by reduction of functional COSMC molecular chaperone in the cell and/or by reduction of functional T-synthase in the cell; and overexpress β1,4-galactosyltransferase in the cell; and associated methods, kits and uses.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux

Abrégé

The invention provides a method of prognosing and/or diagnosing heart disease or heart failure in a subject, comprising determining the methylation status and/or expression level of at least one methylation marker selected from the group consisting of MFSD2B, miR24-1, TTPA, GALNT15, ITGBL1, SMOC2, MSR1, PVT1, MYOM3, COX17, MYBPC3, HEY2, and MRPL44 wherein the methylation status and/or expression level of at least one methylation marker is indicative of the prognosis and/or diagnosis of said subject. A panel of biomarkers, means, a kit and a device for use in assessing risk of HCM, ISCM and DCM are disclosed.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

The present invention relates to a device for use in the delivery of an active agent. Specifically, the present invention relates to a device comprising a scaffold that can be formed from a polymer or co-polymer; a matrix; and at least one active agent. The device finds utility in the delivery of at least one active agent, and is useful in methods of reducing cell infiltration, inflammation and collagen deposition in a tissue or treating fibrosis in a tissue. In an aspect, the device can alleviate post-operative inflammation and/or fibrosis; and can also improve patient compliance for effective delivery of an active agent.

Classes IPC  ?

• A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 27/20 - Polysaccharides
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61L 31/04 - Matériaux macromoléculaires
• A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
• A61L 31/16 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques

Abrégé

The present invention provides a fractional-N frequency synthesizer comprising a divider controller comprising a multistage noise Shaping (MASH) digital delta-sigma modulator comprising L error feedback modulator (EFM) stages, wherein the jth EFM stage is configured to receive as an input the sum of the error of the preceding EFM stage and a high amplitude dither signal derived from the error of the kth EFM stage, where 1≤j≤k≤L.

Classes IPC  ?

• H03L 7/197 - Synthèse de fréquence indirecte, c.-à-d. production d'une fréquence désirée parmi un certain nombre de fréquences prédéterminées en utilisant une boucle verrouillée en fréquence ou en phase en utilisant un diviseur de fréquence ou un compteur dans la boucle une différence de temps étant utilisée pour verrouiller la boucle, le compteur comptant entre des nombres variables dans le temps ou le diviseur de fréquence divisant par un facteur variable dans le temps, p. ex. pour obtenir une division de fréquence fractionnaire
• H03M 3/00 - Conversion de valeurs analogiques en, ou à partir d'une modulation différentielle

Abrégé

A method of analysing a target bodily tissue of a subject. The method involves manipulating image data from the target bodily tissue and a background bodily tissue after dosing the subject with a contrast agent. The relative intensities of the light emitted from selected areas of the target bodily tissue and background bodily tissue at different time points after dosing are compared to determine whether 1) the intensity of light emitted from the target bodily tissue is lower than the intensity of light emitted from the background bodily tissue during the first part of the time period; and/or 2) the intensity of light emitted from the target bodily tissue is higher than the intensity of light emitted from the background bodily tissue during the second part of the time period; to assist in the determination of whether the target bodily tissue is benign or malignant.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 1/31 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour le rectum, p. ex. proctoscopes, sigmoïdoscopes
• A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
• A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement