An access monitoring system for a commodity storage system includes at least one processor, and at least one non-transitory computer-readable storage medium storing instructions thereon that, when executed by the at least one processor, cause the access monitoring system to receive a request to access a container storing the commodity, cause one or more sensors within a container storing the commodity, to obtain sensor data comprising a concentration of one or more of carbon dioxide, ammonia, hydrogen sulfide, oxygen, and dust, receive the sensor data at a location remove from the container, and responsive to receiving the access request and the sensor data, provide an indication of whether a worker may enter the container, based at least in part, on the sensor data. Related methods and systems are also disclosed.
A monitoring system for a commodity handling system includes at least one processor and at least one non-transitory computer-readable storage medium storing instructions thereon that, when executed by the at least one processor, cause the monitoring system to receive, from an access controller, access data from one or more access sensors in a container, the access data indicative of an access condition of the container, receive an access request from a client device, and responsive to receiving the access request, cause the access controller to cause at least one door of the container to unlock. Related methods and commodity handling system are also disclosed.
A monitoring system configured to generate at least one image depicting a commodity within a container storing the commodity, determine a location of one or more abnormalities within the commodity, and provide a notification indicative of the location of the one or more abnormalities within the container. A method includes applying energy to a commodity within a container and measuring reflected energy that has passed through at least a portion of the commodity, based on the measured reflected energy, generating, with a commodity monitoring system, at least one image depicting the commodity within the container, and determining a location of one or more abnormalities within the commodity relative to a location of an auger of the container. Related systems are also disclosed.
An exoskeletal rehabilitation device supports a hand, a lower arm portion, and an upper arm portion of a user relative to a supporting surface for rehabilitating the arm. The device has a shoulder frame that pivots about a first shoulder axis relative to a base frame fixed onto the supporting surface. An upper arm frame alongside the upper arm portion pivots on the shoulder frame about a second shoulder axis transverse to the first. A lower arm frame alongside the lower arm portion pivots on the upper arm frame about an upright elbow axis. A wrist frame supports a handle frame that receives the hand relative to the lower arm frame. The wrist frame pivots on the lower arm frame about a longitudinal axis longitudinal of the lower arm portion, while the handle frame pivots on the wrist frame about a wrist axis for flexion and extension of the hand.
Novel methodology and controller for hysteresis current control in modular multilevel converters (MMCs). With this novel acceleration slope-based hysteresis current control, the MMC can behave as a high-bandwidth and high-precision current source with much reduced power loss in comparison with the two-level voltage source converter (VSC) with traditional hysteresis current control. At regular sampling intervals, a value of the outputted AC current signal is compared against a prescribed range whose upper and lower limits straddle a reference current signal to which the outputted AC current signal is to be conformed. If the measured value is above or below the range, a current/time slope of the reference current is decreased or increased, respectively, to modify a reference voltage to be imparted at the output port of the MMC to control the outputted AC current signal.
NSCs expressing the full length human SOD1 increasingly express biomarkers of cellular senescence with repeated passages in vitro. In this process, levels of misfolded hSOD1 in the NSCs increase with the increased number of passages. Selective removal of misfolded SOD1 from NSCs remarkably increases proliferation and sternness of NSCs. Our study also reveals that extracellular vesicles (EVs) derived from senescent NSCs expressing the wild type hSOD1 contain high level of misfolded SOD1 that is oxidized and toxic to cultured neurons. Also provided is a method for growing cells comprising: growing a quantity of cells in a suitable growth media comprising an effective amount of a peptide comprising a lysosomal targeting motif and a domain specific for the derlin-binding region of superoxide dismutase 1.
Pseudomonas aeruginosaPseudomonas aeruginosa infections is enhanced with the inclusion of an outer membrane permeabilizing tobramycin derivative.The optimized guanidinylated tobramycin-biphenyl derivatives are non-cytotoxic and demonstrated the ability to potentiate ceftazidime and aztreonam monotherapy and in dual combinations with avibactam against multidrug-resistant and β-lactamase harboring isolates of P. aeruginosa. The triple combination of ceftazidime/avibactam plus guanidinylated tobramycin-biphenyl resulted in a rapid bactericidal activity within 4 – 8 hours of treatment, demonstrating the potential application of these guanidinylated amphiphilic tobramycin derivatives in augmenting BL/BLI.
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
Building strong underwater bioadhesion is important for several applications but proved to be an extremely challenging task. In a wet/underwater environment, the water boundary layer hinders interfacial adhesion, which is further undermined by water-induced swelling in bioadhesives. In contrast to current hydrophilic bioadhesives, we here propose an underwater and in-situ applicable hydrophobic adhesive (UIHA). We report polydimethylsiloxane (PDMS) tangled with macromolecular silicone fluid as a dissipation phase to provide strong interface adhesion strength. The silicone fluid repels the surface boundary water layer, overcomes capillary break up in water, and rapidly gelates with PDMS, while a small amount of silane (<0.2%) can bridge the hydrophobic adhesive and tissue substrates to an exceptional underwater adhesive strength. UIHA presents in-situ and instant adhesive performances when tested on artery, lung, bone, and skin tissues.
Compounds, compositions and method of using these compounds are disclosed for treating a disease or disorder in which it is desirable to inhibit BAX, such as a cardiovascular disease or disorder.
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
C07D 209/86 - CarbazolesCarbazoles hydrogénés avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du système cyclique
C07D 209/88 - CarbazolesCarbazoles hydrogénés avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du système cyclique
C07D 279/26 - Thiazines-1, 4Thiazines-1, 4 hydrogénées condensés avec des carbocycles ou avec des systèmes carbocycliques condensés en [b, e] avec deux cycles à six chaînons avec des atomes de carbone liés directement à l'atome d'azote du cycle avec des radicaux hydrocarbonés, substitués par des radicaux amino, liés à l'atome d'azote du cycle sans autres substituants liés au système cyclique
C07D 295/13 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'azote liés par des liaisons simples ou doubles avec les atomes d'azote du cycle et les atomes d'azote substituants liés à la même chaîne carbonée, qui n'est pas interrompue par des cycles carbocycliques à une chaîne acyclique saturée
A biosensor for real-time monitoring of a wound can provide valuable data regarding the presence of bacteria. A nanofibrous biosensor is provided for monitoring wound status at the point of care. The colorimetric biosensor changes color in response to low levels of bacteria and fungi, making it visible to unaided and untrained eyes. A colorimetric probe is a hemicyanine dye that changes color from yellow to green in the presence of lipase. Dye is incorporated into a shell composition of core-shell nanofibers made of polyurethane and polyvinylpyrrolidone. As a means of increasing the biosensor's sensitivity, the alignment of nanofibers is controlled and a surfactant added to the shell (e.g., Tween 80). Alignment of nanofiber enables better localization, and Tween 80 increases lipase activity, which facilitates near immediate color changes above critical levels of Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Candida aureus. All ESKAPEE bacteria are detected within 2 hours.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
C12Q 1/44 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase une estérase
11.
Energy Storage and Reutilization for a Single-Rod Electro-Hydrostatic Actuator
A method for storing and reutilizing energy during operation of a hydrostatic actuator (EHA) having a hydraulic cylinder, a first bidirectional pump-motor rotationally coupled to an electric motor, and EHA valving and connections between the first pump-motor and the hydraulic cylinder. During at least one of two motoring quadrants, a hydraulic accumulator is charged using a second pump-motor whose rotation is driven by load-driven motoring of the first bidirectional pump-motor. During at least one of the pumping quadrants, driven rotation is imparted to the second pump-motor using stored energy from the accumulator, and said driven rotation of the second pump-motor is used to augment powered rotation of the first bidirectional pump-motor by the electric motor.
F15B 1/033 - Installations ou systèmes comprenant des accumulateurs comportant des dispositifs de remplissage des accumulateurs avec des moyens de commande électriques
F15B 1/02 - Installations ou systèmes comprenant des accumulateurs
F15B 1/027 - Installations ou systèmes comprenant des accumulateurs comportant des dispositifs de remplissage des accumulateurs
12.
METHOD OF OBTAINING CHANNEL STATE INFORMATION IN WIRELESS COMMUNICATION NETWORK HAVING ARTIFICIAL WAVE TRANSFORMER
A method of obtaining channel state information of a communication channel between a user device and an access point with plural antennas features steps of forming separate statistical models representative of a first channel portion between the access point and a wave transformer located at a geographically intermediate location between the access point and the user device, which is configured to reflect electromagnetic signals between the access point and the user device and has electronically reconfigurable antennas, and a second channel portion between the wave transformer and the user device; and processing, using respective machine learning algorithms configured to determine parameters of a type of tractable statistical distribution selected to represent both the first and second portions of the channel, a transmitted signal so as to form parametrized tractable statistical distributions respectively defining the separate statistical models of the first and second portions of the communication channel.
H04B 7/06 - Systèmes de diversitéSystèmes à plusieurs antennes, c.-à-d. émission ou réception utilisant plusieurs antennes utilisant plusieurs antennes indépendantes espacées à la station d'émission
H04W 24/02 - Dispositions pour optimiser l'état de fonctionnement
13.
Method for Determining Conductors Involved in a Fault on a Power Transmission Line and Fault Location Using Local Current Measurements
There is disclosed a method for identifying one or more faulted conductors in a power transmission system having at least two power-transmitting conductors and a method for determining fault location. Both methods include steps of monitoring current signals which are representative of currents in the conductors at a generally common location within the power transmission system; filtering the current signals; determining a maximum rate of change of each filtered current signal within a predetermined time interval after the fault event has commenced; and calculating a ratio of a pair of the maximum rates of change of the filtered current signals. For fault classification, the ratio is compared against a discrimination factor to identify the one or more faulted conductors. For fault location, the calculated ratio is compared against the calibration data to determine the distance from the connection terminal of the faulted conductor to the fault location.
G01R 31/08 - Localisation de défauts dans les câbles, les lignes de transmission ou les réseaux
H02J 3/00 - Circuits pour réseaux principaux ou de distribution, à courant alternatif
H02J 3/36 - Dispositions pour le transfert de puissance électrique entre réseaux à courant alternatif par l'intermédiaire de haute tension à courant continu
H02J 13/00 - Circuits pour pourvoir à l'indication à distance des conditions d'un réseau, p. ex. un enregistrement instantané des conditions d'ouverture ou de fermeture de chaque sectionneur du réseauCircuits pour pourvoir à la commande à distance des moyens de commutation dans un réseau de distribution d'énergie, p. ex. mise en ou hors circuit de consommateurs de courant par l'utilisation de signaux d'impulsion codés transmis par le réseau
14.
COMPUTER-IMPLEMENTED METHOD FOR GENERATING ANTI-NOISE
A method for generating anti-noise comprises receiving a sound signal representative of ambient sound including noise from a noise source, anti-noise from an anti-noise generator, and propagation noise from environment; processing the sound signal using a deep learning algorithm configured to generate an anti-noise signal to form anti-noise; and outputting the anti-noise signal to the anti-noise generator. The deep learning algorithm features an iterative encoder module forming plural feature maps; an attention module generating plural attention maps respectively based on the feature maps; a recurrent neural network (RNN), with long short-term memory layers receiving the feature map of the final iteration of the encoder module, predicting a future portion of the sound signal and modelling temporal features of the feature map of the final encoder module iteration; and an iterative decoder module mapping the output of the RNN to the anti-noise signal having common dimensions as the sound signal.
G10K 11/178 - Procédés ou dispositifs de protection contre le bruit ou les autres ondes acoustiques ou pour amortir ceux-ci, en général utilisant des effets d'interférenceMasquage du son par régénération électro-acoustique en opposition de phase des ondes acoustiques originales
15.
SYSTEMS AND METHODS FOR IN-SITU CHARACTERIZATION OF PERMAFROST SITES
A method of quantifying a plurality of parameters of a subsurface structure comprising a region of interest, the method comprising the steps of: with at least one vibratory source, emitting an input wave signal into the subsurface structure to cause generation of seismic wave signals in the subsurface structure; with at least one receiver, acquiring and measuring the seismic wave signals from the subsurface structure, wherein the seismic wave signals comprise at least one first Rayleigh wave (R1) signal and at least one second Rayleigh wave (R2) signal associated with the region of interest; generating, at a data processing apparatus, seismic data associated with measurements of the seismic wave signals; determining, at the data processing apparatus, from the seismic data a relationship between the Rayleigh wave (R1, R2) signals, wherein the Rayleigh wave (R1, R2) signals are dependent on at least one of the plurality of parameters.
A system for analyzing internet traffic passing through an exposed computer device includes a preprocessing module for filtering the traffic so as to substantially isolate from the traffic features carrying data representative of a cyberattack, a perception module for extracting the data from the isolated features, a detection module for processing the extracted data to detect characteristics indicative of the cyberattack, and a mitigation module for generating responsive action if a cyberattack is detected.
A commodity monitoring system configured to receive measurement data from an antenna probe of an antenna array mounted within a container, compare the received measurement data to reference measurement data of a known state of the antenna probe of the antenna array, and based at least partially on the comparison, determine whether the antenna probe of the antenna array is in a commodity within the container or out of the commodity within the container. A method includes applying an energy to the commodity via at least one antenna probe, receiving remaining energy via at least one other antenna probe of the antenna array, based on the received remaining energy, determine measurement data; compare the determined measurement data to reference measurement data, and determine whether the given antenna probe of the antenna array is in the commodity within the container or out of the commodity within the container.
A new fluorine-free tantalum carbide MXene-tantalum oxides (TTO) nanostructure was developed as a biocompatible electrode material for size-sensitive applications. The TTO hybrid structure is biocompatible with different types of human cells, and offers excellent volumetric capacitance, energy density, power density, and cyclability when assembled into a symmetric supercapacitor. The TTO offers high promise for future biomedical energy storage devices.
We have recently developed a novel DC-targeting vaccine platform using Ebola glycoprotein (EboGP) DC-targeting domain-based fusion protein technology. Here, we will use this technology to generate universal vaccines against Influenza A by fusing a DC-targeting/activation domain (EboGPAM), derived from EboGP to I) a tetrameric conserved extracellular domain of M2 (M2e) of Influenza A strains from human, birds, and swine; 2) the conserved stalk regions (HAcs) of HA and an M2 polypeptide from H5N1 strain; and 3) the HA head regions polypeptides (HAH5-1-3) derived from H5N1, H1 N1 and H3N2 strains.
Treatments for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof. The treatments includes administration of compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.
A61K 31/5513 - 1,4-Benzodiazépines, p. ex. diazépam
A61K 31/46 - Aza-8-bicyclo[3.2.1]octaneSes dérivés, p. ex. atropine, cocaïne
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/5517 - 1,4-Benzodiazépines, p. ex. diazépam condensées avec des cycles à cinq chaînons ayant l'azote comme hétéro-atome d'un cycle, p. ex. imidazobenzodiazépines, triazolam
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
In one embodiment, an electromagnetic imaging method, comprising: determining frequency domain information from measurements; converting the frequency domain information to time domain information; and using the time domain information to parametrically describe a state of a stored commodity.
In one embodiment, a method, comprising: receiving measurement data of a container with contents stored within the container; performing a phaseless parametric inversion on the measurement data to provide a background model; determining calibration coefficients for each of a plurality of channels based on the measurement data and the background model; and determining calibrated scattered field measurements based on the background model and the calibration coefficients.
In one embodiment, a system, comprising: a neural network, configured to: receive electromagnetic field measurement data from an object of interest as input to the neural network, the neural network trained on labeled data; and reconstruct a three-dimensional (3D) distribution image of a physical property of the object of interest from the received electromagnetic field measurement data, the reconstruction implemented without performing a forward solve during the reconstruction.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
24.
1H-PYRAZOLE ANALOGUES AND METHODS AND USES THEREOF
A compound having a structure of Formula (I), a pharmaceutically-acceptable salt thereof, hydrate thereof, solvate thereof, tautomer thereof, geometric isomer thereof, enantiomer thereof, diastereomer thereof, N-oxide thereof, metabolite thereof, isotopomer thereof, isotopologue thereof, prodrug thereof, or combination thereof. The compound/composition may be used for prevention and/or treatment of a disease, condition and/or disorder associated with oxidative stress, such as, but not limited to, neurodegeneration, aging, etc.
Elevated bile acids in patients with Fontan circulation have an inverse relationship with age, frailty, skeletal muscle mass and body composition, exercise capacity and hemodynamic parameters. While not wishing to be bound to a particular theory or hypothesis, it is believed that bile acids mediate mitochondrial dysfunction leading to impaired cardiomyocyte contractility resulting in diastolic dysfunction, impaired response to physiological stress (inability to increase heart rate and hence augment cardiac output), as well as progressive liver fibrosis and skeletal muscle wasting. As such, screening of blood samples of Fontan patients can be carried out, wherein elevated bile acid pools are indicative that intervention should be undertaken to reduce these bile acid pools, thereby preventing or slowing liver fibrosis and ultimately liver cirrhosis and myocardial dysfunction.
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/92 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des lipides, p. ex. le cholestérol
G01N 33/483 - Analyse physique de matériau biologique
26.
Electromagnetic detection and localization of storage bin hazards and human entry
A system for detecting human entry into a container using electromagnetic imaging to generate image maps of the container. The system includes a door monitor configured to detect an entry door open event associated with the container. The system uses one or more processors and a memory with instructions to generate a baseline image map of the container, detect an entry door open event with the door monitor associated with the container, generate a post entry door open event image map of the container, and compare the baseline image map generated before the entry door open event with image map generated after the entry door open event.
G01S 13/04 - Systèmes déterminant la présence d'une cible
B65D 88/08 - Grands réceptacles rigides cylindriques à axe vertical
B65D 90/00 - Parties constitutives, détails ou accessoires des grands réceptacles
B65D 90/22 - Caractéristiques relatives à la sécurité
G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c.-à-d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
G01S 7/41 - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe utilisant l'analyse du signal d'écho pour la caractérisation de la cibleSignature de cibleSurface équivalente de cible
G06T 7/62 - Analyse des attributs géométriques de la superficie, du périmètre, du diamètre ou du volume
27.
METHOD OF CALIBRATING OPTICAL COHERENCE TOMOGRAPHY APPARATUS TO MEASURE DEPTH
A method of calibrating an apparatus configured to perform optical coherence tomography to measure depth of an article of a prescribed type comprises (a) using an existing measurement system configured to measure depth, measuring a sample of the article to obtain reference depth measurements; b) using the optical coherence tomography apparatus, capturing sectional images of the sample at the same positions at which the reference depth measurements were obtained; c) determining, in each sectional image, a number of pixels in a depth direction of the sample; and d) determining, using the reference depth measurements and the numbers of pixels from the sectional images, a correlation curve to associate pixels in images captured by optical coherence tomography with physical depth. Measuring the sample comprises performing plural measurements at different positions on the sample. Each measurement is in the form of a profile of the sample at a corresponding position thereon.
G01B 9/02055 - Réduction ou prévention d’erreursTestÉtalonnage
G01B 9/02091 - Interféromètres tomographiques, p. ex. à cohérence optique
G01B 11/22 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la profondeur
G06T 7/521 - Récupération de la profondeur ou de la forme à partir de la télémétrie laser, p. ex. par interférométrieRécupération de la profondeur ou de la forme à partir de la projection de lumière structurée
28.
CHRONIC GRAFT-VERSUS-HOST DISEASE (CGVHD) DIAGNOSTIC AND RISK BIOMARKER PANELS, METHODS AND USES THEREOF
This invention provides chronic graft-versus-host disease (cGVHD) biomarker panels for use in diagnostic and risk assignment methods. More particularly, the invention relates to particular combinations of biomarkers for diagnosing cGVHD and for predicting whether there is a low, intermediate or high risk of developing cGVHD. Furthermore, there are provided different treatment options depending on a patient's risk level or whether they have moderate to severe cGVHD.
C40B 40/02 - Bibliothèques contenues ou présentées dans des micro-organismes, p. ex. des bactéries ou des cellules animalesBibliothèques contenues ou présentées dans des vecteurs, p. ex. des plasmidesBibliothèques contenant uniquement des micro-organismes ou des vecteurs
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
C40B 30/00 - Procédés de criblage des bibliothèques
C40B 40/10 - Bibliothèques comprenant des peptides ou des polypeptides ou leurs dérivés
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/483 - Analyse physique de matériau biologique
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G16B 25/10 - Profilage de l’expression de gènes ou de protéinesEstimation ou normalisation de ratio d’expression
29.
Variable Split Displacement Ratio Axial Piston Machines
A variable split displacement ratio axial piston machine, featuring a rotatable driveshaft, a tapered swashplate disposed around said rotatable driveshaft, a first working section disposed on a first side of the tapered swashplate, and a second working section disposed on a second side of the tapered swashplate. Each working section includes a respective set of pistons slidably received in a respective set of cylinder bores to draw and expel fluid into and from said cylinder bores. The first and second working sections respectively interface with first and second outer faces of the tapered swashplate in respective first and second facial planes. Tiltable adjustment of a working position of the tapered swashplate is operable to adjust respective orientations of the facial planes, which dictate relative piston stroke lengths of the piston sets. Such tiltable adjustment imparts control over a variable split displacement ratio between the working sections.
F04B 1/29 - Commande pour "machines" ou pompes à cylindres immobiles en modifiant les positions relatives d'un plateau oscillant et d'un bloc-cylindres
F04B 17/03 - Pompes caractérisées par leur combinaison avec des machines motrices ou moteurs particuliers qui les entraînent ou par leur adaptation à ceux-ci entraînées par des moteurs électriques
F15B 15/18 - Ensembles combinés comportant moteur et pompe
A transducer for use with a rotary bearing rotatably interconnecting an inner member along a rotational axis and an outer member supporting the rotary bearing comprises a piezoelectric body arranged for physical deformation; a pair of electrodes arranged to receive an electrical signal generated by the piezoelectric body in response to physical deformation thereof; a substantially incompressible force-transmission member on one end of the piezoelectric body and defining an exterior contact surface for operative mechanical engagement with the rotary bearing to receive vibration therefrom; electrical insulation surrounding the piezoelectric body and arranged to prevent transmission of an electrical signal generated thereby to a proximal electrically conductive body; and a substantially electrically nonconductive base in opposite relation to the force-transmission member and covering a corresponding end of the piezoelectric body. In use, the transducer is mounted adjacent a receptacle receiving the bearing so as to be in operative mechanical engagement therewith.
In one embodiment, a method implemented by an electromagnetic imaging system for imaging material within a metal container, the method comprising: transmitting to, and receiving signals from, a plurality of antennas attached to an interior wall of the metal container, the signals delivered over a plurality of channels, each of the plurality of antennas comprising a ferrite loaded, shielded half-loop antenna; measuring a plurality of scattering parameters (S-parameters) for all of the plurality of channels; calibrating the measurements; and providing an image of the material using an inversion algorithm based on the calibrated measurements.
G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c.-à-d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
H01Q 1/22 - SupportsMoyens de montage par association structurale avec d'autres équipements ou objets
H01Q 1/52 - Moyens pour réduire le couplage entre les antennesMoyens pour réduire le couplage entre une antenne et une autre structure
H01Q 7/06 - Cadres ayant une distribution du courant sensiblement uniforme et un diagramme de rayonnement directif perpendiculaire au plan du cadre avec un noyau en matière ferromagnétique
32.
ELECTROMAGNETIC IMAGING FOR LARGE STORAGE BINS USING FERRITE LOADED SHIELDED HALF-LOOP ANTENNAS
In one embodiment, a method implemented by an electromagnetic imaging system for imaging material within a metal container, the method comprising: transmitting to, and receiving signals from, plural antennas attached to an interior wall of the metal container, the signals delivered over a plurality of channels, each of the plural antennas comprising a ferrite loaded, shielded half- loop antenna; measuring a plurality of scattering parameters (S-parameters) for all of the plurality of channels; calibrating the measurements; and providing an image of the material using an inversion algorithm based on the calibrated measurements.
G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c.-à-d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
H01Q 1/38 - Forme structurale pour éléments rayonnants, p. ex. cône, spirale, parapluie formés par une couche conductrice sur un support isolant
A generalization of the Harrow/Hassidim/Lloyd algorithm is developed by providing an alternative unitary for eigenphase estimation adopted from research in the area of quantum walks, which has the advantage of being well defined for any arbitrary matrix equation. The procedure is most useful for sparse matrix equations, as it allows for the inverse of a matrix to be applied with (Nnz log(N)) complexity, where N is the number of unknowns, and Nnz is the total number of nonzero elements in the system matrix. This efficiency is independent of the matrix structure, and hence the quantum procedure can outperform classical methods for many common system types. We show this using the example of sparse approximate inverse (SPAI) preconditioning, which involves the application of matrix inverses for matrices with Nnz=(N).
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
Multiple sclerosis (MS) is characterized by immune mediated neurodegeneration that results in progressive, life-long neurological and cognitive impairments. Yet, the endogenous mechanisms underlying MS pathophysiology are not fully understood. Here, we provide compelling evidence that associates dysregulation of neuregulin-1 beta 1 (Nrg-1β1) with MS pathogenesis and progression. In the experimental autoimmune encephalomyelitis (EAE) model of MS, we demonstrate that Nrg-1β1 levels are abated within spinal cord lesions and peripherally in the plasma and spleen during presymptomatic, onset and progressive course of the disease. We demonstrate that plasma levels of Nrg-1β1 are also significantly reduced in individuals with early MS and is positively associated with progression to relapsing-remitting MS. The functional impact of Nrg-1β1 downregulation preceded disease onset and progression, and its systemic restoration was sufficient to delay EAE symptoms and alleviate disease burden. Intriguingly, Nrg-1β1 therapy exhibited a desirable and extended therapeutic time window of efficacy when administered prophylactically, symptomatically, acutely or chronically. Using in vivo and in vitro assessments, we identified that Nrg-1β1 treatment mediates its beneficial effects in EAE by providing a more balanced immune response. Mechanistically, Nrg-1β1 moderated monocyte infiltration at the blood-central nervous system interface by attenuating chondroitin sulfate proteoglycans and matrix metalloproteinase-9. Moreover, Nrg-1β1 fostered a regulatory and reparative phenotype in macrophages, T helper type 1 (Th1) cells and microglia in the spinal cord lesions of EAE mice. Taken together, our new findings in MS and EAE have uncovered a novel regulatory role for Nrg-1β1 early in the disease course and suggest its potential as a specific therapeutic target to ameliorate disease progression and severity.
In one embodiment, a system comprising: a container configured to store commodity; a measurement system comprising a vector network analyzer (VNA), a switch module, a plurality of cables, the container, and a plurality of antennas coupled to interior walls of the container, the switch module configured to switch signals transmitted to and received from the plurality of antennas via a plurality of channels, the VNA configured to measure scattering parameters (S-parameters) of all of the plurality of channels; a non-transitory computer readable medium comprising software; and a processor configured by the software to: de-embed a combined effect of the measurement system based on a 2-port network de-embedding technique using only a subset of the S-parameters; and provide an image of the commodity using an inversion algorithm based on input of a calibrated S-parameter after the de-embedding.
G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c.-à-d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
Screening for novel antibacterial compounds in small molecule libraries has a low success rate. Here, we applied a machine learning (ML)-based virtual screening for antibacterial activity and evaluated its predictive power by experimental validation. We first binarized thirty-thousand compounds according to their growth inhibitory activity (hit rate 0.67%) against the antibiotic-resistant bacterium Burkholderia cenocepacia and described their molecular features with a directed-message passing neural network (D-MPNN). Then, we used the data to train an ML model that achieved a receiver operating characteristic (ROC) score of 0.823 on the test set. Finally, we predicted antibacterial activity in virtual libraries corresponding to 1,614 compounds from the Food and Drug Administration (FDA)-approved list and 224,205 natural products. A hit rate of 26% and 12%, respectively, was obtained when we tested the top ranked predicted compounds for growth inhibitory activity against B. cenocepacia, which represents at least a 12-fold increase from the previous hit rate. In addition, more than 51 % of the predicted antibacterial natural compounds inhibited ESKAPE pathogens showing that predictions expand beyond the organism-specific dataset to a broad range of bacteria. Overall, the developed ML approach can be used for compound prioritization prior to screening, increasing the typical hit rate of high throughput screens. Also described are anti-bacterial compounds isolated by the screen.
A61K 31/35 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle
A61K 31/045 - Composés hydroxylés, p. ex. alcoolsLeurs sels, p. ex. alcoolates
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 31/382 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des cycles à six chaînons, p. ex. thioxanthènes
A61K 31/409 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant quatre de ces cycles, p. ex. dérivés de la porphine, bilirubine, biliverdine
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61K 31/473 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. acridines, phénantridines
A61K 31/4045 - Indole-alkylaminesLeurs amides, p. ex. sérotonine, mélatonine
A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
C07C 35/21 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons polycycliques, avec au moins un groupe hydroxyle lié à un cycle non condensé
C07C 205/04 - Composés contenant des groupes nitro liés à un squelette carboné ayant des groupes nitro liés à des atomes de carbone acycliques d'un squelette carboné non saturé contenant des cycles aromatiques à six chaînons
C07C 229/12 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe amino et un seul groupe carboxyle liés au squelette carboné l'atome d'azote du groupe amino étant lié de plus à des atomes de carbone acycliques ou à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons à des atomes de carbone de squelettes carbonés acycliques
C07C 229/26 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant plus d'un groupe amino lié au squelette carboné, p. ex. lysine
C07D 207/32 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
C07D 311/20 - Benzo [b] pyrannes non hydrogénés dans le carbocycle avec des atomes d'oxygène ou de soufre liés directement en position 2 hydrogénés dans l'hétérocycle
C07D 335/02 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome de soufre comme unique hétéro-atome du cycle non condensés avec d'autres cycles
A wearable rehabilitation device features a wearable support sized and shaped for worn fitting thereof over a body part of a patient, one or more vibratory stimulators on the wearable support that are positioned and operable to stimulate muscle tendon tissue of said body part of the patient, and one or more accelerometers on the wearable support configured to generate output signals responsive to vibration of said one or more vibratory stimulators. A controller compares output signals from the accelerometer against a targeted vibrational frequency, and adjusts operating conditions of the stimulator based on detected disagreement to achieve the targeted frequency for optimal therapeutic effect.
A61H 23/02 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement électrique ou magnétique
39.
VIBRATORY BURROWING PROBE FOR INVESTIGATING SUBSURFACE REGIONS OF GRANULAR MEDIA IN 1G AND LOW/MICRO GRAVITY CONDITIONS
A compact vibratory burrowing probe, particularly beneficial in low gravity space exploration environments, uses lateral or stirring-like vibrations to fluidize a surrounding regolith, thereby decreasing the penetration resistance, and compensating for the light overhead weight to improve the burrowing action of the probe into the surface of the terrain of explored moons, planets, or asteroids. Included is a novel vibratory mechanism capable of imparting the novel lateral or stirring vibration, as well as a more conventionally oriented longitudinal vibration.
E21B 7/24 - Forage utilisant des moyens vibrants ou oscillants, p. ex. des masses déséquilibrées
E21B 49/00 - Test pour déterminer la nature des parois des trous de forageEssais de couchesProcédés ou appareils pour prélever des échantillons du terrain ou de fluides en provenance des puits, spécialement adaptés au forage du sol ou aux puits
40.
MICROFLUIDIC URINE ALBUMIN/CREATININE CHIP (UACR-CHIP) FOR CHRONIC KIDNEY DISEASE EVALUATION
Provided is a microfluidic device for measurement of albumin and creatinine in a biological sample, such as urine, and methods for fabricating such devices. Also provided are methods of detecting albumin and creatinine and a ratio of albumin to creatinine in a biological fluid sample to diagnose or monitor a chronic kidney disease.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p. ex. utilisation de bandes de papier indicateur
41.
CELL-FREE WIRELESS COMMUNICATION NETWORK FOR COMMUNICATING WITH DISTRIBUTED USERS AND RELATED METHODS
A wireless communication network comprises access points distributed across a geographical area and configured to wirelessly communicate with distributed user devices in the area, and a central server communicatively connected to the access points and configured to control the network. The access points are grouped, based on channel state information, to form a plurality of communication clusters each in wireless communication with a subset of the user devices in geographically proximal location thereto, and each communication cluster and its subset of user devices forms a subnetwork. The subnetworks are arranged for wireless communication in nonoverlapping portions of the geographical area. The access points of a common subnetwork are configured to wirelessly exchange data with the subnetwork’s user devices using a common frequency range. Each communication cluster comprises an edge computing device formed by one or more of the access points belonging thereto and configured to exchange data with the server.
A novel, integrated dual-modal breast imaging system that requires minimal or no movement of the breast between scans. A static receptacle holds the breast or other target object still. An acoustic imaging fixture with acoustic transducers, and an electromagnetic imaging chamber with electromagnetic antennae, each perform imaging of the target object when occupying a respective working position of surrounding relationship to the receptacle, and at least one thereof is movable relative to said static receptacle into and out of the respective working position, without repositioning of the static receptacle. Acoustic imaging is performed, and prior information extracted from the sound-speed image is incorporated into the electromagnetic inversion algorithm, whereby low-resolution sound-speed reconstructions are used to improve tumour detection via electromagnetic imaging.
An electromagnetic imaging method uses a reduced set of whole domain basis functions that is chosen in an informed manner from prior information about the imaging problem, using prior information to tailor the choice of 'alternative' basis functions, e.g., first seeking layered structure in a grain storage bin, then providing support for hot-spots. In one embodiment, the method first uses a pulse basis and then projects the basis onto the 'alternative' basis. This allows for more than one 'alternative' basis at each iteration. Similarities and differences between the target reconstruction in different alternative bases can be used to guide the reconstruction procedure. In an alternate embodiment the method constructs the 'alternative basis' directly and modifies the underlying inversion algorithm to accommodate the new basis. The method uses the information to parametrically describe a state of a stored commodity.
Provided are paper-based microfluidic devices for measurement of cystatin C in a biological sample, such as blood or a blood fraction, and methods for fabricating such devices. Also provided are methods of detecting cystatin C in a biological fluid sample to diagnose or monitor a chronic kidney disease.
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/537 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec séparation du complexe immunologique de l'antigène ou de l'anticorps non liés
G01N 33/541 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec séparation du complexe immunologique de l'antigène ou de l'anticorps non liés faisant intervenir un réactif de précipitation faisant intervenir un double ou un deuxième anticorps
G01N 33/558 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet utilisant la diffusion ou la migration de l'anticorps ou de l'antigène
B81B 1/00 - Dispositifs sans éléments mobiles ou flexibles, p. ex. dispositifs capillaires microscopiques
A computer-implemented method for generating anti-noise using an anti-noise generator to suppress noise from a noise source in an environment comprises processing a sound signal, which is representative of ambient sound including noise, anti-noise and propagation noise from the environment, using a deep learning algorithm configured to generate an anti-noise signal to form anti-noise. The deep learning algorithm comprises a convolution layer; after the convolution layer, a series of atrous scaled convolution modules, wherein each of the atrous scaled convolution modules comprises an atrous convolution, a nonlinear activation function after the atrous convolution, and a pointwise convolution after the nonlinear activation function; after the series of atrous scaled convolution modules, a recurrent neural network; and after the recurrent neural network, a plurality of fully connected layers.
G10K 11/178 - Procédés ou dispositifs de protection contre le bruit ou les autres ondes acoustiques ou pour amortir ceux-ci, en général utilisant des effets d'interférenceMasquage du son par régénération électro-acoustique en opposition de phase des ondes acoustiques originales
In one embodiment, a system, comprising: one or more processors; and a memory comprising instructions, wherein the one or more processors are configured by the instructions to: receive first electromagnetic data at a plurality of frequencies; process the first electromagnetic data; and generate prediction parameters by passing the processed first electromagnetic data through a neural network trained on data corresponding to a synthetic training set, the prediction parameters corresponding to a container and contents located within the container.
Described herein is a “paperclip” structured dsRNA (pcRNA) that has two closed ends (FIG. 1), and was developed and tested for its ability to enter insect cells and induce RNAi. While conventional dsRNAs, with their two collinear RNA strands, enter insect cells by clathrin-mediated endocytosis, the pcRNAs can enter cells by a clathrin-independent mechanism. The new structured dsRNA can be used to deliver dsRNA to insects that either develop resistance through alterations to their conventional uptake mechanisms and to insects that are naturally refractory to dsRNAs, including lepidopteran pests.
The present disclosure relates to a reusable facemask that is endowed with a potential for antimicrobial properties. In some embodiments of the present disclosure, the antimicrobial properties are chargeable and rechargeable by exposure to a halogen. Without being bound by any particular theory, such reusable masks with rechargeable antiviral properties may offer a variety of benefits, including active killing of the virus during filtration, reducing the risk of contamination due to handling PPE during or after use, alleviating demand-driven pressure on PPE supply chains, and reducing waste due to the reusable nature of the mask.
C09D 7/80 - Procédés pour l'incorporation d'ingrédients
A41D 13/11 - Masques de protection du visage, p. ex. pour utilisation chirurgicale ou pour utilisation en atmosphère polluée
A61L 2/16 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques
A device for electrically connecting a direct current (DC) microgrid to a DC bus of an electrical power network, which is operating at a higher voltage than the microgrid, comprises a pair of electrical port each configured for connection with either the DC bus or the microgrid; a DC-DC power converter operatively interconnecting the electrical ports for power transmission therebetween from a first voltage at the port connected to the DC bus to a lower second voltage at the port connected to the DC microgrid; a DC circuit breaker connected between the DC-DC power converter and one of the electrical ports for selectively conducting current therebetween; and a controller which is configured to communicate with constituent devices in the DC microgrid as well as a control center representative of the electrical power network in order to exchange information about electrical energy consumption in the DC microgrid and the larger network.
H02J 13/00 - Circuits pour pourvoir à l'indication à distance des conditions d'un réseau, p. ex. un enregistrement instantané des conditions d'ouverture ou de fermeture de chaque sectionneur du réseauCircuits pour pourvoir à la commande à distance des moyens de commutation dans un réseau de distribution d'énergie, p. ex. mise en ou hors circuit de consommateurs de courant par l'utilisation de signaux d'impulsion codés transmis par le réseau
A 3D vision system in viewing relationship to an industrial robot's workspace obtains a 3D point cloud to identify and locate an arbitrarily placed target part, calculates required adjustment of the target part's actual position against an initially "taught" reference position, and automatically adjusts the robot's programmed movements to accurately match the target part's position. Teaching of desired robot pose(s) relative to the reference position is performed with a physical reference part without need for CAD models, offline programming or operator expertise. The robot can execute simple pick and place operations involving a singular taught robot pose, but also more complex operations with toolpaths whose waypoints are composed of a plurality of taught robot poses. Rather than transforming taught robot poses, another implementation involves deriving a part frame from taught reference points, transforming the part frame, and updating the active working frame of the robot to the transformed part frame.
An exoskeletal rehabilitation device supports a hand, a lower arm portion, and an upper arm portion of a user relative to a supporting surface for rehabilitating the arm. The device has a shoulder frame that pivots about a first shoulder axis relative to a base frame fixed onto the supporting surface. An upper arm frame alongside the upper arm portion pivots on the shoulder frame about a second shoulder axis transverse to the first. A lower arm frame alongside the lower arm portion pivots on the upper arm frame about an upright elbow axis. A wrist frame supports a handle frame that receives the hand relative to the lower arm frame. The wrist frame pivots on the lower arm frame about a longitudinal axis longitudinal of the lower arm portion, while the handle frame pivots on the wrist frame about a wrist axis for flexion and extension of the hand.
A61H 1/00 - Appareils pour l'exercice passifAppareils vibrateursDispositifs de chiropractie, p. ex. dispositifs pour appliquer des chocs au corps, dispositifs externes pour étirer ou aligner de façon brève des os non fracturés
Described herein is a strategy for converting 2D transition-metal titanium carbide MXene (M3X2Tx) sheets to multi-dimensional GerMXene superlattice heterostructure. The GerMXene possesses a unique microstructure with enhanced surface properties compared to its parent materials, MXene and Xene (GeH). Also, GerMXene offers excellent biocompatibility and bioactivity with tailored electrical and optical properties for application in multiple fields.
Building strong underwater bioadhesion is important for several applications but proved to be an extremely challenging task. In a wet/underwater environment, the water boundary layer hinders interfacial adhesion, which is further undermined by water-induced swelling in bioadhesives. In contrast to current hydrophilic bioadhesives, we here propose an underwater and in-situ applicable hydrophobic adhesive (UIHA). We report polydimethylsiloxane (PDMS) tangled with macromolecular silicone fluid as a dissipation phase to provide strong interface adhesion strength. The silicone fluid repels the surface boundary water layer, overcomes capillary break up in water, and rapidly gelates with PDMS, while a small amount of silane (<0.2%) can bridge the hydrophobic adhesive and tissue substrates to an exceptional underwater adhesive strength. UIHA presents in-situ and instant adhesive performances when tested on artery, lung, bone, and skin tissues.
Described herein is a biocompatible lipid nanoparticle (LNP) composition suitable for delivering RNA payloads into cells and tissues of a subject. The biocompatible LNPs comprise an ionizable cationic lipid as a core component and have a net neutral surface charge at physiological pH. Delivery of LNP-encapsulated siRNA inhibiting the expression Spermidine/spermine N1-acetyltransferase 1 (SAT1) is shown to inhibit proliferation of a glioblastoma cell line, but not in other cells pertinent to brain tissue such as microvascular endothelial cells, primary human astrocytes, and macrophage cells. Use of a cadherin-binding peptide to increase delivery of LNP-encapsulated siRNA across a blood-brain barrier monolayer model is also described.
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
59.
GLIOBLASTOMA TUMOR GROWTH INHIBITON BY SAT1 KNOCKDOWN
Described herein is a biocompatible lipid nanoparticle (LNP) composition suitable for delivering RNA payloads into cells and tissues of a subject. The biocompatible LNPs comprise an ionizable cationic lipid as a core component and have a net neutral surface charge at physiological pH. Delivery of LNP-encapsulated siRNA inhibiting the expression Spermidine/spermine N1-acetyltransferase 1 (SAT1) is shown to inhibit proliferation of a glioblastoma cell line, but not in other cells pertinent to brain tissue such as microvascular endothelial cells, primary human astrocytes, and macrophage cells. Use of a cadherin-binding peptide to increase delivery of LNP-encapsulated siRNA across a blood-brain barrier monolayer model is also described.
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
60.
CONDUCTING POLYMER-BASED ELECTRODE MATRICES FOR LITHIUM-ION BATTERIES
Polypyrrole:carboxymethyl cellulose (PPy:CMC) composites were synthesized by in situ chemical oxidative polymerization. Following that, carbon-additive-free LiCoO2/PPy:CMC cathodes were fabricated by using water as a processing solvent. Carbon-additive-free cathodes were then cycled to study the performance of PPy:CMC electrode matrices. The results indicate that PPy:CMC composites were electrochemically stable within the cathode operating voltage window. As the cycle number increased, electrolyte anions became dopants for PPy units in PPy:CMC composites. The sharp spike in cell voltage of LiCoO2/PPy:CMC cathodes in the first charging cycle indicated that undoped/neutral PPy units in PPy:CMC composite were oxidized and doped to become fully conductive. This unique phenomena teaches an activation procedure for using other CP-based electrode matrices in Li-ion batteries such as polyaniline:carboxymethyl cellulose (PANI:CMC) composites.
H01M 4/137 - Électrodes à base de polymères électro-actifs
H01M 4/1399 - Procédés de fabrication d’électrodes à base de polymères électro-actifs
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
61.
CONDUCTING POLYMER-BASED ELECTRODE MATRICES FOR LITHIUM-ION BATTERIES
Polypyrrole:carboxymethyl cellulose (PPy:CMC) composites were synthesized by in situ chemical oxidative polymerization. Following that, carbon-additive-free LiCoO2/PPy:CMC cathodes were fabricated by using water as a processing solvent. Carbon-additive-free cathodes were then cycled to study the performance of PPy:CMC electrode matrices. The results indicate that PPy:CMC composites were electrochemically stable within the cathode operating voltage window. As the cycle number increased, electrolyte anions became dopants for PPy units in PPy:CMC composites. The sharp spike in cell voltage of LiCoO2/PPy:CMC cathodes in the first charging cycle indicated that undoped/neutral PPy units in PPy:CMC composite were oxidized and doped to become fully conductive. This unique phenomena teaches an activation procedure for using other CP-based electrode matrices in Li-ion batteries such as polyaniline:carboxymethyl cellulose (PANI:CMC) composites.
H01M 4/137 - Électrodes à base de polymères électro-actifs
H01M 4/1399 - Procédés de fabrication d’électrodes à base de polymères électro-actifs
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
62.
DUAL-ACTION RECOMBINANT VESICULAR STOMATITIS VIRUS (RVSV)-BASED VACCINE (DAV) AGAINST COVID-19 AND INFLUENZA VIRUSES
Described herein is a replicative Vesicular stomatitis virus (rVSV) comprising: a first Filoviridae glycoprotein comprising one or more influenza virus matrix 2 ectodomain peptide inserted into the first Filoviridae glycoprotein; and a second Filoviridae glycoprotein comprising a SARS-CoV2 Spike protein peptide inserted into the second Filoviridae glycoprotein, or a first Filoviridae glycoprotein comprising one or more influenza virus matrix 2 ectodomain peptide inserted into the first Filoviridae glycoprotein and a non-functional but immunogenic SARS-CoV2 Spike protein. The Spike protein or Spike protein peptide can be derived from different CoV- 2 variants. The rVSV can be used as a Dual Action vaccine for vaccinating individuals simultaneously against both influenza virus and SARS CoV2 virus.
C07K 14/71 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des facteurs de croissanceRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des régulateurs de croissance
C07K 14/165 - Coronaviridae, p. ex. virus de la bronchite infectieuse aviaire
This invention provides methods and apparatuses for the rapid assessment of cell permeability by a drug. More particularly, described herein a method of determining membrane permeability (influx and/or efflux) of a cell to a drug, the method including: (a) obtaining a biological sample; (b) dispersing at least one cell from the biological sample to a discrete location; (c) exposing the at least one cell to one member of a drug panel in a drug solution, wherein the drug panel is composed of drugs of a given concentration; (d) incubating the at least one cell from the biological sample in the drug for a given time; (e) obtaining at least one electro-analytical measurement of the discrete location adjacent the at least one cell.
G01Q 60/60 - Microscopie électrochimique à balayage SECM [Scanning Electro-Chemical Microscopy] ou appareils à cet effet, p. ex. sondes SECM
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
G01N 27/30 - Électrodes, p. ex. électrodes pour testsDemi-cellules
There are provided processes for treating a residual. For example, such processes can comprise treating a mixture comprising the residual, a peracid or source thereof and an ammonium salt in a reactor, with an electric field, by means of at least one anode and at least one cathode that define therebetween an electrokinetic zone for treating the mixture. Such processes allow for inactivation of at least one type of pathogen in the residual so as to obtain a treated residual.
C02F 11/00 - Traitement des boues d'égoutDispositifs à cet effet
B09C 1/08 - Régénération de sols pollués par des procédés chimiques
C02F 1/467 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse par désinfection électrochimique
A direct current circuit breaker comprises a mechanical relay in a first supply line configured to conduct electrical current during steady-state operation and an auxiliary relay assembly in parallel with the mechanical relay to define an auxiliary breaker path for conducting electrical current during transient operation of the circuit breaker. The auxiliary relay assembly comprises a power-semiconductor circuit configured for selective current conduction and for bidirectional current blocking when in a non-conductive state. There is also a controller configured to (i) activate the power-semiconductor circuit to conduct in response to a command signal to stop transfer of the electrical power, in order to provide a zero voltage condition under which the mechanical relay is to deactivate; (ii) deactivate the mechanical relay when current is being conducted through the auxiliary breaker path; and (iii) deactivate the power-semiconductor circuit after the mechanical relay is deactivated to stop the transfer of the power.
A method of quantifying a plurality of parameters of a subsurface structure comprising a region of interest, the method comprising the steps of: with at least one vibratory source, emitting an input wave signal into the subsurface structure to cause generation of seismic wave signals in the subsurface structure; with at least one receiver, acquiring and measuring the seismic wave signals from the subsurface structure, wherein the seismic wave signals comprise at least one first Rayleigh wave (R1) signal and at least one second Rayleigh wave (R2) signal associated with the region of interest; generating, at a data processing apparatus, seismic data associated with measurements of the seismic wave signals; determining, at the data processing apparatus, from the seismic data a relationship between the Rayleigh wave (R1, R2) signals, wherein the Rayleigh wave (R1, R2) signals are dependent on at least one of the plurality of parameters.
A computer-implemented method for analyzing an image to detect an article of interest (AOI) comprises processing the image using a machine learning algorithm configured to detect the AOI and comprising a convolutional neural network (CNN); and displaying the image with location of the AOI being indicated if determined to be present. The CNN comprises an input module configured to receive the image and comprising at least one convolutional layer, batch normalization and a nonlinear activation function; an encoder thereafter and configured to extract features indicative of a present AOI to form a feature map; a decoder thereafter and configured to discard features from the feature map that are not associated with the present AOI and to revert the feature map to a size matching an initial image size; and a concatenation module configured to link outputs of the input module, the encoder and the decoder for subsequent segmentation.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 10/77 - Traitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source
G06V 10/771 - Sélection de caractéristiques, p. ex. sélection des caractéristiques représentatives à partir d’un espace multidimensionnel de caractéristiques
G06V 10/26 - Segmentation de formes dans le champ d’imageDécoupage ou fusion d’éléments d’image visant à établir la région de motif, p. ex. techniques de regroupementDétection d’occlusion
G06V 10/80 - Fusion, c.-à-d. combinaison des données de diverses sources au niveau du capteur, du prétraitement, de l’extraction des caractéristiques ou de la classification
A new fluorine-free tantalum carbide MXene-tantalum oxides (TTO) nanostructure was developed as a biocompatible electrode material for size-sensitive applications. The TTO hybrid structure is biocompatible with different types of human cells, and offers excellent volumetric capacitance, energy density, power density, and cyclability when assembled into a symmetric supercapacitor. The TTO offers high promise for future biomedical energy storage devices.
The present disclosure includes a boron containing complex that includes a boron compound including boron-10 (10B); and a carrier compound including a right-handed coiled coil-nanotube (RHCC-NT) portion, the RHCC-NT portion having at least one internal cavity, wherein the boron compound is located within the at least one internal cavity of the RHCC-NT portion of the carrier compound to form the boron containing complex. Methods of making and using the boron containing complex are also included.
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A rapid, low-cost, portable and reliable method for on-site detection of deoxynivalenol (DON), a representative mycotoxin predominantly occurring in grains, would be helpful to control mycotoxin contamination. Herein, a paper-based microfluidic chip capable of measuring deoxynivalenol (DON-Chip) in foods, feeds and feed ingredients was developed. As discussed herein, the DON-Chip incorporated a colorimetric competitive immunoassay into a paper microfluidic device and used gold nanoparticles as a signal indicator. Furthermore, a novel ratiometric analysis method was used to improve signal resolvability at low concentrations of DON. Detection of DON in aqueous extracts from solid foods, feeds or feed ingredients was successfully validated with a detection range from 0.01-20 ppm (using dilution factors from 10-104). Compared with conventional methods, the novel DON-Chip greatly reduces the cost and time of mycotoxin detection in the food and feed industry.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
In one embodiment, an electromagnetic imaging method comprises: determining frequency domain information from measurements (104); converting the frequency domain information to time domain information (106); and using the time domain information to parametrically describe a state of a stored commodity (108).
In one embodiment, an electromagnetic imaging method comprises: determining electromagnetic resonance data based on interrogating a stored commodity (112); and estimating features of the stored commodity based on the electromagnetic resonance data (114).
In one embodiment, a method, comprising: receiving measurement data of a container with contents stored within the container; performing a phaseless parametric inversion on the measurement data to provide a background model; determining calibration coefficients for each of a plurality of channels based on the measurement data and the background model; and determining calibrated scattered field measurements based on the background model and the calibration coefficients.
In one embodiment, an electromagnetic imaging method comprises: determining electromagnetic resonance data based on interrogating a stored commodity (112); and estimating features of the stored commodity based on the electromagnetic resonance data (114).
In one embodiment, a method, comprising: receiving measurement data of a container with contents stored within the container; performing a phaseless parametric inversion on the measurement data to provide a background model; determining calibration coefficients for each of a plurality of channels based on the measurement data and the background model; and determining calibrated scattered field measurements based on the background model and the calibration coefficients.
In one embodiment, a system, comprising: a neural network, configured to: receive electromagnetic field measurement data from an object of interest as input to the neural network, the neural network trained on labeled data; and reconstruct a three-dimensional (3D) distribution image of a physical property of the object of interest from the received electromagnetic field measurement data, the reconstruction implemented without performing a forward solve during the reconstruction.
In one embodiment, an electromagnetic imaging method comprises: determining frequency domain information from measurements (104); converting the frequency domain information to time domain information (106); and using the time domain information to parametrically describe a state of a stored commodity (108).
In one embodiment, a system, comprising: a neural network, configured to: receive electromagnetic field measurement data from an object of interest as input to the neural network, the neural network trained on labeled data; and reconstruct a three-dimensional (3D) distribution image of a physical property of the object of interest from the received electromagnetic field measurement data, the reconstruction implemented without performing a forward solve during the reconstruction.
An ultrasonic sensing technique and a signal interpretation method based on a spectral element multiphase poromechanical approach overcomes critical gaps in permafrost, frozen soil, and saturated soil characterization. Ultrasonic sensing produces high-quality response signals that are sensitive to the soil properties. A transfer function denoting a ratio of induced displacement and applied force in the frequency domain, is independent of the distribution of the stress force applied by the transducer to the sample, and allows interpretation of the measured electrical signal using a theoretical transfer function relation to efficiently determine the most probable properties from response signals using an inverse spectral element multiphase poromechanical approach. This ultrasonic sensing technique enables rapid characterization of soil samples in terms of both physical and mechanical properties. The Quantitative Ultrasound (QUS) system can be used in a laboratory setup or brought on site for in-situ investigation of permafrost, frozen, and saturated soil samples.
Disclosed is an olfaction system based on integration of gas sensitive conducting polymers and Floating Gate Metal Oxide Semiconductor (FGMOS) sensors. A sensing polymer, polypyrrole for example, is electrochemically deposited onto sensor pads which are electrically connected to floating gate of the sensor. The response of these sensing polymers to any vapour analyte can be tailored using several techniques that include the use of different dopants, changing electrolyte concentrations or varying growth potential at the time of electrodeposition. Using an array of floating gate sensors, coupled to these chemically diverse polymers, this system will facilitate a signature-like response from the sensors in the array. Every sensor can be accessed and analysed individually using a specially designed addressing circuit. The response from the sensors is amplified through a trans-impedance amplifier and converted to 8-bit digital data for ease of analyte identification and quantification.
Herein, we describe conducting polymer composites that demonstrate pressure-sensitive electrical conductivity. These composites can be fabricated by inexpensive and environmental-friendly chemical polymerization. One example thereof are polypyrrole:carboxymethyl-cellulose (PPy:CMC) composites that have a unique core-shell structure where a thin layer of non-conductive CMC matrix covers electrically conductive PPy:CMC spheres. Such a structure-assisted quantum tunneling conduction takes place whenever pressure is applied. Also described herein is the designing of pressure-sensing devices derived from conducting polymers.
H01L 29/12 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
G01L 1/18 - Mesure des forces ou des contraintes, en général en utilisant des propriétés des matériaux piézo-résistants, c.-à-d. des matériaux dont la résistance ohmique varie suivant les modifications de la grandeur ou de la direction de la force appliquée au matériau
82.
Computer-implemented method of analyzing an image to segment article of interest therein
2 pixels and a depth of d channels; (ii) processing the image using a machine learning algorithm configured to segment the article of interest, the machine learning algorithm comprising a convolutional neural network including: at least one convolution layer; after said at least one convolution layer, at least one separable convolution module comprising a series of separable convolutions, each separable convolution comprising a depthwise convolution and a pointwise convolution; after said at least one separable convolution module, a pooling module; and a decoder module after the pooling module; and (iii) displaying the image with location of the article of interest being indicated if determined to be present by the machine learning algorithm.
in vitroin vitro. This novel microfluidic device allowed us, for the first time, to quantitatively analyze human T cell migration in a multicellular 3D environment under controlled single and competing chemical gradient conditions. We demonstrate the feasibility and potential of this SoC model as a new medium throughput discovery and screening tool to study the involvement of T cell trafficking in complex chemical fields during cytokine-stimulated skin inflammation.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
84.
Homodimeric Tobramycin Adjuvant Repurposes Novobiocin as an Effective Antibacterial Agent Against Gram-Negative Bacteria
Low permeability across the outer membrane is a major reason why most antibiotics are ineffective against Gram-negative bacteria. Agents that permeabilize the outer membrane are typically toxic at their effective concentrations. Here, we report the development of a broad-spectrum homodimeric tobramycin adjuvant that is non-toxic and more potent than the gold standard permeabilizing agent, polymyxin B nonapeptide. In pilot studies, the adjuvant confers potent bactericidal activity on novobiocin against Gram-negative bacteria, including carbapenem-resistant and colistin-resistant strains bearing plasmid-borne mcr-1 genes. Resistance development to the combination was significantly reduced, relative to novobiocin alone, and there was no induction of cross-resistance to other antibiotics, including the gyrase-acting fluoroquinolones. Tobramycin homodimer may allow the use of lower doses of novobiocin, overcoming its twin-problem of efficacy and toxicity.
A61K 31/41 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec plusieurs hétéro-atomes cycliques, l'un au moins étant l'azote, p. ex. tétrazole
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
A61K 47/55 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique l’agent de modification étant aussi un agent pharmacologiquement ou thérapeutiquement actif, c.-à-d. le conjugué entier étant un co-médicament, p. ex. un dimère, un oligomère ou un polymère de composés pharmacologiquement ou thérapeutiquement actifs
Flea beetles (species of the genus Phyllotreta) are serious pests of cruciferous crops, causing millions of dollars losses each year, despite the use of chemical pesticides. Our current pesticides are broad-spectrum in their activity, killing not just the pests, but also many non-target species, including beneficial insects such as pollinators and predators. Here, an alternative set of pesticides, based on double-stranded RNA (dsRNA), is shown to be effective at killing flea beetles when the dsRNAs are applied to a leaf surface and fed to the insects. Insects that fed on leaves sprayed with the dsRNAs died within 8 days of first exposure, but also showed reduced feeding activity within several days, thereby reducing feeding damage to the plants. Importantly, the dsRNAs were designed to be specific for the flea beetles, and when delivered to non-target beetles, no adverse effects were observed, illustrating the specificity of this new type of pesticide.
We identified Panx1 as a new binding partner of STIM proteins and demonstrate how ER Ca2+ store depletion induces activation of Panx1 channels in a STIM dependent manner. Using Panx1 deletion variants, we identified the STIM interaction domain within the intracellular N-terminus of Panx1 (amino acids 1-18), which is necessary for promoting Panx1 activation. Further, in hippocampal cultured neurons we show that ionotropic function of NMDARs causes Panx1 activation and knockdown of STIM inhibits Panx1 activation. Panx1-STIM region controls NMDAR-initiated Panx1 activation confirming the model of NMDAR-STIM-Panx1 signalling. N-term (amino acids 19-35) is responsible for plasma membrane trafficking of Panx1 channels. The STIM interaction region of Panx1 is at amino acids 13-18. This region is required to stimulate the pathological activation of Panx1, a response linked to detrimental actions of amyloid beta. This technology provides a target to treat Alzheimer's disease.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p. ex. utilisation de bandes de papier indicateur
87.
SPECTRAL DIFFERENTIAL EQUATION APPROXIMATION METHOD FOR MIXED POTENTIAL GREEN'S FUNCTIONS IN MULTILAYERED MEDIA
The invention provides a method to compute the mixed potential contributions to electric and magnetic field in multilayered media, which can be applied in microwave engineering, integrated circuit analysis, and remote sensing. The Spectral Differential EquationApproximation Method (SDEAM) for solving Michalski-Zheng's mixed-potential Green's functions in fully shielded, partially open, and fully open multilayered media are described. The main advantage of SDEAM over other methods is that for a fixed location of the source elevation z', it does not require fitting from scratch for every z, z', and ρ combination. Because of this advantage, SDEAM can be superior in both performance and accuracy to other existing methods.The well-established boundary value problem numerical solvers also provide SDEAM with robustness for miscellaneous planar multilayered structures.
G01N 27/00 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques
G01R 31/00 - Dispositions pour tester les propriétés électriquesDispositions pour la localisation des pannes électriquesDispositions pour tests électriques caractérisées par ce qui est testé, non prévues ailleurs
G01R 31/28 - Test de circuits électroniques, p. ex. à l'aide d'un traceur de signaux
G01V 3/00 - Prospection ou détection électrique ou magnétiqueMesure des caractéristiques du champ magnétique de la terre, p. ex. de la déclinaison ou de la déviation
G06F 17/13 - Opérations mathématiques complexes pour la résolution d'équations d'équations différentielles
G06F 17/14 - Transformations de Fourier, de Walsh ou transformations d'espace analogues
G16C 20/00 - Chémo-informatique, c.-à-d. TIC spécialement adaptées au maniement des données physicochimiques ou structurelles des particules, des éléments, des composés ou des mélanges chimiques
88.
A WEARABLE MUSCLE TENDON VIBRATION DEVICE FOR REHABILITATION
A wearable rehabilitation device features a wearable support sized and shaped for worn fitting thereof over a body part of a patient, one or more vibratory stimulators on the wearable support that are positioned and operable to stimulate muscle tendon tissue of said body part of the patient, and one or more accelerometers on the wearable support configured to generate output signals responsive to vibration of said one or more vibratory stimulators. A controller compares output signals from the accelerometer against a targeted vibrational frequency, and adjusts operating conditions of the stimulator based on detected disagreement to achieve the targeted frequency for optimal therapeutic effect.
A61H 1/00 - Appareils pour l'exercice passifAppareils vibrateursDispositifs de chiropractie, p. ex. dispositifs pour appliquer des chocs au corps, dispositifs externes pour étirer ou aligner de façon brève des os non fracturés
89.
USE OF NRG-1BETA1 FOR DETECTION AND/OR TREATMENT OF MULTIPLE SCLEROSIS
Multiple sclerosis (MS) is characterized by immune mediated neurodegeneration that results in progressive, life-long neurological and cognitive impairments. Yet, the endogenous mechanisms underlying MS pathophysiology are not fully understood. Here, we provide compelling evidence that associates dysregulation of neuregulin-1 beta 1 (Nrg-1β1) with MS pathogenesis and progression. In the experimental autoimmune encephalomyelitis (EAE) model of MS, we demonstrate that Nrg-1β1 levels are abated within spinal cord lesions and peripherally in the plasma and spleen during pre-symptomatic, onset and progressive course of the disease. We demonstrate that plasma levels of Nrg-1β1 are also significantly reduced in individuals with early MS and is positively associated with progression to relapsing-remitting MS. The functional impact of Nrg-1β1 downregulation preceded disease onset and progression, and its systemic restoration was sufficient to delay EAE symptoms and alleviate disease burden. Intriguingly, Nrg-1β1 therapy exhibited a desirable and extended therapeutic time window of efficacy when administered prophylactically, symptomatically, acutely or chronically. Using in vivo and in vitro assessments, we identified that Nrg-1β1 treatment mediates its beneficial effects in EAE by providing a more balanced immune response. Mechanistically, Nrg-1β1 moderated monocyte infiltration at the blood-central nervous system interface by attenuating chondroitin sulfate proteoglycans and matrix metalloproteinase-9. Moreover, Nrg-1β1 fostered a regulatory and reparative phenotype in macrophages, T helper type 1 (Th1) cells and microglia in the spinal cord lesions of EAE mice. Taken together, our new findings in MS and EAE have uncovered a novel regulatory role for Nrg-1β1 early in the disease course and suggest its potential as a specific therapeutic target to ameliorate disease progression and severity.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 14/485 - Facteur de croissance de l'épiderme [EGF], c.-à-d. urogastrone
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
90.
USE OF NRG-1BETA1 FOR DETECTION AND/OR TREATMENT OF MULTIPLE SCLEROSIS
Multiple sclerosis (MS) is characterized by immune mediated neurodegeneration that results in progressive, life-long neurological and cognitive impairments. Yet, the endogenous mechanisms underlying MS pathophysiology are not fully understood. Here, we provide compelling evidence that associates dysregulation of neuregulin-1 beta 1 (Nrg-1?1) with MS pathogenesis and progression. In the experimental autoimmune encephalomyelitis (EAE) model of MS, we demonstrate that Nrg-1?1 levels are abated within spinal cord lesions and peripherally in the plasma and spleen during pre-symptomatic, onset and progressive course of the disease. We demonstrate that plasma levels of Nrg-1?1 are also significantly reduced in individuals with early MS and is positively associated with progression to relapsing-remitting MS. The functional impact of Nrg-1?1 downregulation preceded disease onset and progression, and its systemic restoration was sufficient to delay EAE symptoms and alleviate disease burden. Intriguingly, Nrg-1?1 therapy exhibited a desirable and extended therapeutic time window of efficacy when administered prophylactically, symptomatically, acutely or chronically. Using in vivo and in vitro assessments, we identified that Nrg-1?1 treatment mediates its beneficial effects in EAE by providing a more balanced immune response. Mechanistically, Nrg-1?1 moderated monocyte infiltration at the blood-central nervous system interface by attenuating chondroitin sulfate proteoglycans and matrix metalloproteinase-9. Moreover, Nrg-1?1 fostered a regulatory and reparative phenotype in macrophages, T helper type 1 (Th1) cells and microglia in the spinal cord lesions of EAE mice. Taken together, our new findings in MS and EAE have uncovered a novel regulatory role for Nrg-1?1 early in the disease course and suggest its potential as a specific therapeutic target to ameliorate disease progression and severity.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 14/485 - Facteur de croissance de l'épiderme [EGF], c.-à-d. urogastrone
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
91.
Metal complexes, methods of making the same, and uses thereof
The present disclosure relates to new metal complexes, including derivatives thereof, methods of making the metal complexes, and uses thereof, including uses, for example, as photosensitizers and as photocatalysts. In an embodiment, a metal complex having the structure of Formula (I): a salt, hydrate, solvate, tautomer, optical isomer, or combination thereof.
H10K 30/30 - Dispositifs organiques sensibles au rayonnement infrarouge, à la lumière, au rayonnement électromagnétique de plus courte longueur d'onde ou au rayonnement corpusculaire comprenant des hétérojonctions de masse, p. ex. des réseaux interpénétrés de domaines de matériaux donneurs et accepteurs
B01J 31/18 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination contenant de l'azote, du phosphore, de l'arsenic ou de l'antimoine
Herein, we demonstrate a hierarchical nano-structured water purification membrane fabricated with polyvinyl alcohol (PVA) nanofibers and polypyrrole (PPy) nanoparticles to achieve efficient emulsion separation with low oil-adhesion property as well as high-rate seawater desalination. The membrane exhibits the integrated properties of mechanical robustness, superhydrophilic/underwater superoleophobic wettability and broadband solar absorption.
C08L 29/04 - Alcool polyvinyliqueHomopolymères ou copolymères d'esters partiellement hydrolysés d'alcools non saturés avec des acides carboxyliques saturés
In one embodiment, a system, comprising: one or more processors; and a memory comprising instructions, wherein the one or more processors are configured by the instructions to: receive first electromagnetic data at a plurality of frequencies; process the first electromagnetic data; and generate prediction parameters by passing the processed first electromagnetic data through a neural network trained on data corresponding to a synthetic training set, the prediction parameters corresponding to a container and contents located within the container.
G01V 3/12 - Prospection ou détection électrique ou magnétiqueMesure des caractéristiques du champ magnétique de la terre, p. ex. de la déclinaison ou de la déviation fonctionnant par ondes électromagnétiques
G01F 23/00 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p. ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme
In one embodiment, a system, comprising: one or more processors; and a memory comprising instructions, wherein the one or more processors are configured by the instructions to: receive first electromagnetic data at a plurality of frequencies; process the first electromagnetic data; and generate prediction parameters by passing the processed first electromagnetic data through a neural network trained on data corresponding to a synthetic training set, the prediction parameters corresponding to a container and contents located within the container.
G01F 23/00 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p. ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme
G01V 3/12 - Prospection ou détection électrique ou magnétiqueMesure des caractéristiques du champ magnétique de la terre, p. ex. de la déclinaison ou de la déviation fonctionnant par ondes électromagnétiques
We developed a method using monoclonal antibodies (mAbs) targeting different protein domains of FRAS-related extracellular matrix protein 1 (FREM1) to detect and quantify soluble toll-like interleukin-1 receptor regulator (sTILRR) in human plasma samples. We used affinity purification and Western blot analysis to validate the results. Using these methods we quantified sTILRR in the plasma samples. Our study showed that TILRR exists as a soluble protein in human blood plasma that can be quantified.
G01N 33/577 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet faisant intervenir des anticorps monoclonaux
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
A bacteria-responsive color-changing, core-shell nanofiber, comprising polyurethane (PU), a hemicyanine-based chromogenic probe localized in the core-shell nanofiber near the surface of the shell, polyvinylpyrrolidone (PVP) dopant in the shell, the hemicyanine-based chromogenic probe further comprising a labile ester linkage that is enzymatically cleavable by bacterial lipase released from clinically relevant strains of bacteria including Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA).
D01D 5/00 - Formation des filaments, fils ou similaires
A61L 15/24 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carboneLeurs dérivés
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61F 13/00 - Bandages ou pansementsGarnitures absorbantes
A61L 15/26 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carboneLeurs dérivés
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61L 15/46 - Désodorisants ou produits pour neutraliser les mauvaises odeurs, p. ex. pour inhiber la formation d'ammoniac ou la multiplication de bactéries
D01F 1/10 - Autres agents modifiant les propriétés de ces filaments
D01F 8/14 - Filaments, ou similaires, faits par l’homme, conjugués, c.-à-d. à plusieurs composantsLeur fabrication à partir de polymères synthétiques avec au moins un polyester comme constituant
D01F 8/10 - Filaments, ou similaires, faits par l’homme, conjugués, c.-à-d. à plusieurs composantsLeur fabrication à partir de polymères synthétiques avec au moins un autre composé macromoléculaire obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone comme constituant
A method for receiving, at a communications station which has a plurality of antennas, messages from a plurality of users in wireless communication with the communications station, comprising the steps of: (i) receiving, from the users, using the plurality of antennas, time-slotted information chunks formed from the messages of the users, wherein the information chunks are free of any encoded user-identifiers representative of the users transmitting the messages; (ii) after receiving all of the information chunks, estimating vectors representative of respective communication channels between the antennas and the users based on the received information chunks; (iii) grouping the information chunks based on the estimated vectors to form clusters of the information chunks respectively associated with the users; and (iv) recovering the messages of the users from the clusters of the information chunks.
H04B 7/04 - Systèmes de diversitéSystèmes à plusieurs antennes, c.-à-d. émission ou réception utilisant plusieurs antennes utilisant plusieurs antennes indépendantes espacées
A wearable rehabilitation device features a wearable support sized and shaped for worn fitting thereof over a body part of a patient, one or more vibratory stimulators on the wearable support that are positioned and operable to stimulate muscle tendon tissue of said body part of the patient, and one or more accelerometers on the wearable support configured to generate output signals responsive to vibration of said one or more vibratory stimulators. A controller compares output signals from the accelerometer against a targeted vibrational frequency, and adjusts operating conditions of the stimulator based on detected disagreement to achieve the targeted frequency for optimal therapeutic effect.
A61H 1/00 - Appareils pour l'exercice passifAppareils vibrateursDispositifs de chiropractie, p. ex. dispositifs pour appliquer des chocs au corps, dispositifs externes pour étirer ou aligner de façon brève des os non fracturés
99.
USE OF PAPERCLIP RNA STRUCTURE TO INHIBIT TARGET GENE EXPRESSION
Described herein is a "paperclip" structured dsRNA (pcRNA) that has two closed ends (Figure 1), and was developed and tested for its ability to enter insect cells and induce RNAi. While conventional dsRNAs, with their two collinear RNA strands, enter insect cells by clathrin-mediated endocytosis, the pcRNAs can enter cells by a clathrin-independent mechanism. The new structured dsRNA can be used to deliver dsRNA to insects that either develop resistance through alterations to their conventional uptake mechanisms and to insects that are naturally refractory to dsRNAs, including lepidopteran pests.
An ultrasonic sensing technique and a signal interpretation method based on a spectral element multiphase poromechanical approach overcomes critical gaps in permafrost characterization. Ultrasonic sensing produces high-quality response signals that are sensitive to the permafrost properties. A transfer function denoting a ratio of induced displacement and applied force in the frequency domain, is independent of the distribution of the stress force applied by the transducer to the permafrost sample, and allows interpretation of the measured electrical signal using a theoretical transfer function relation to efficiently determine the most probable permafrost properties from response signals using an inverse spectral element multiphase poromechanical approach. This ultrasonic sensing technique enables rapid characterization of permafrost samples in terms of both physical and mechanical properties. The Quantitative Ultrasound (QUS) system can be used in a laboratory setup or brought on site for in-situ investigation of permafrost or frozen soil samples.
G01N 29/30 - Dispositions pour l'étalonnage ou la comparaison, p. ex. avec des objets standard
G01N 29/52 - Traitement du signal de réponse détecté en utilisant des procédés d'inversion autres que l'analyse spectrale, p. ex. inversion conjuguée de gradient
G01V 1/00 - SéismologieProspection ou détection sismique ou acoustique
