The present invention relates to a novel antigen binding protein comprising at least two CH1 domains, wherein the at least two CH1 domains comprise a cysteine residue at an amino acid position corresponding to position 222 according to Kabat numbering of human IgG1 CH1 domain. The invention further provides related nucleic acids, expression vectors, and host cells. The present invention also provides pharmaceutical compositions comprising said antigen binding protein. Finally, the invention also provides a method for increasing the activity of antigen binding protein.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
An apparatus that displays synthetic scene images for augmented reality, virtual reality and other display types. One or more pairs of input beams (70, 76) are injected into a display panel incorporating a layer (100) of phase matched nonlinear optical (NLO) material. The input beams of each pair are brought to cross each other in the NLO material in a noncollinear geometry to generate a product beam (84) by sum frequency generation that is directed to the eye (160) of a viewer. The synthetic scene image information is impressed on each input beam pair by amplitude and phase modulation to set the amplitude (i.e. brightness), wavevector (i.e. direction) and wavefront radius of curvature (i.e. depth) of the synthetic scene image. For colour display, three pairs of input beams with respective sum frequencies in three primary colours are used.
G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur
G02B 27/00 - Systèmes ou appareils optiques non prévus dans aucun des groupes ,
G02F 1/355 - Optique non linéaire caractérisée par les matériaux utilisés
G02F 1/37 - Optique non linéaire pour la génération de l'harmonique deux
H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
G02B 23/12 - Télescopes ou lunettes d'approche, p. ex. jumellesPériscopesInstruments pour voir à l'intérieur de corps creuxViseursPointage optique ou appareils de visée avec des moyens pour renverser ou intensifier l'image
G02B 26/06 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la phase de la lumière
3.
NANOSTRUCTURED BIREFRINGENT OPTICAL ELEMENTS AND MICROSCOPES WITH NANOSTRUCTURED BIREFRINGENT OPTICAL ELEMENTS
A birefringent optical element for transforming an incident beam of light into two spatially separated output beams of light with orthogonal linear polarizations comprises: a transparent substrate with an input face for receiving the incident beam, an output face, and a uniform thickness between the input face and the output face, the substrate having a non-uniform birefringence in a plane parallel to the input face, the birefringence provided by a plurality of randomly positioned nanostructures within the substrate and configured to cause the incident beam to shear within the substrate into two output beams with orthogonal linear polarisations and wavefronts at an angle to one another so that the output beams leave the output face with a spatial separation along a shear direction parallel to the output face; wherein each nanostructure has an oblate spheroidal shape.
A polarized light microscope includes a light source configured to illuminate a specimen and an imaging sensor configured to capture an image of the specimen. The polarized light microscope also includes a first circular polarizer positioned between the light source and the specimen. A birefringent mosaic mask is positioned between the specimen and the imaging sensor. The polarized light microscope also includes a second polarizer positioned between the mask and the imaging sensor.
Apparatus for use in four wave mixing is disclosed, comprising a nonlinear medium for receiving a plurality of light beams copropagating along an optical path through the nonlinear medium, the plurality of light beams including at least one signal wave having a signal frequency and one or two pump waves having respective pump frequencies, the light beams generating one or more unwanted idler waves in the nonlinear medium. The apparatus further comprises phase adjusting means arranged to selectively apply to wavelengths of light in the nonlinear medium, respective wavelength-dependent phase shifts to adjust the phase difference between the or each pump wave and the signal wave, such that unwanted idler waves are generated along the optical path of the nonlinear medium so as to destructively interfere, suppressing unwanted idler waves at an output of the nonlinear medium. A method of configuring the phase adjusting means is disclosed.
There is provided a method of identifying one or more substances in a sample by: illuminating the sample with light of each of a plurality of different excitation modes; measuring an intensity and/or polarisation of light from the sample at a plurality of wavelengths to obtain a measured spectrum for each of the excitation modes; and identifying one or more substances in the sample using the measured spectra together, wherein: the excitation modes differ in one or both of wavelength and polarisation; and the identifying of the one or more substances uses contributions to the measured spectra from a plurality of photophysical processes in the sample including inelastic scattering of light. An apparatus suitable for carrying out the method is also provided.
The present document discloses a monitoring device for attaching to a marine animal comprising: a pressure sensor for measuring underwater pressure; a first temperature sensor for measuring water temperature; a satellite positioning system for geopositioning the device once on the surface; a first section for facing incoming water when the device is attached to the marine animal, comprising: a first oxygen sensor for measuring dissolved oxygen in the water; a second section for extending beyond a water surface when the device is released from the marine animal and floating, comprising: one or more antennas for communicating with a remote server and receiving and/or transmitting a geolocation signal; wherein the first and second section comprise a floatable outer layer and are coupled in a watertight connection; wherein the first section is a conical frustum, pyramidal frustum, spherical frustum, or trumpet-shaped; wherein the second section is dome-shaped. It is also disclosed a corresponding method of operation and production of the monitoring device.
A method of cooling hydrogen, the method comprising the steps of: (a) flowing an inflow stream of hydrogen vapour from an upstream device into a cooling system; (b) within the cooling system, heating a cold-side solid heat transfer surface with heat transferred, directly or indirectly, from hydrogen undergoing cooling, and providing at least some or all of the cooled hydrogen as a supply of cooled hydrogen; (c) within the cooling system, heating hydrogen with heat transferred by direct contact with the cold-side solid heat transfer surface to form heated hydrogen; and (d) within the cooling system or the upstream device, exposing hydrogen, which hydrogen is in, or to be comprised in, the heated hydrogen and/or the supply of cooled hydrogen, to a catalyst which endothermically yields a net conversion of para-hydrogen to ortho-hydrogen. Also disclosed in an apparatus for cooling hydrogen for implementing the method. There is also disclosed a method and apparatus for cooling a fluid using a regenerator.
An electrochemical flow system is disclosed. In one arrangement, the electrochemical flow system comprises a plurality of flow cells. Each of the flow cells is configured to allow flow of an electrolyte through the flow cell and to contact the electrolyte in the flow cell with one or more electrodes. A flow management system is also provided, comprising a conduit arrangement comprising a first flow unit, the flow cells, and a second flow unit. The conduit arrangement is configured to guide a flow of the electrolyte from the first flow unit through the flow cells and into the second flow unit along an electrolyte flow path. A flow driving arrangement is also provided, configured to drive the flow of the electrolyte along the electrolyte flow path. The flow management system is configured to provide one or more insulating buffers, each insulating buffer spanning the electrolyte flow path upstream or downstream of the plurality of flow cells. The insulating buffer spans the flow path such that, during the flow of the electrolyte through the flow cells, electrolyte located within each flow cell is electrically separated from electrolyte in the other flow cells. This electrical separation is at least via paths through electrolyte respectively upstream or downstream of the plurality of flow cells, by the insulating buffer blocking the paths.
H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires
H01M 8/04186 - Dispositions pour la commande des paramètres des réactifs, p. ex. de la pression ou de la concentration des réactifs chargés en liquide ou en électrolyte
H01M 50/77 - Dispositions pour brasser ou faire circuler l’électrolyte avec un circuit de circulation extérieur
An optical source comprises: a pump source operable to generate laser light at a first wavelength; a single mode optical fibre arranged to receive laser light at the first wavelength from the pump source, the optical fibre being fabricated from material having a Raman gain profile for stimulated Raman scattering of light at the first wavelength, and a Brillouin gain profile for stimulated Brillouin scattering of light at the second wavelength to a third wavelength longer than the second wavelength; and a superstructured fibre Bragg grating formed in the optical fibre, the grating comprising: a periodic refractive index profile along a core of the optical fibre, giving transmission of the first wavelength to allow received laser light at the first wavelength to enter the superstructured fibre Bragg grating, reflection of the second wavelength at a first level, and reflection of the third wavelength at a second level lower than the first level; and a phase shift at an intermediate location along a length of the grating; wherein the series of pulses at the third wavelength comprise a pulsed output of the optical source.
H01S 3/094 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique par de la lumière cohérente
H01S 3/0941 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique par de la lumière cohérente produite par un laser à semi-conducteur, p. ex. par une diode laser
H01S 3/102 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande du milieu actif, p. ex. par commande des procédés ou des appareils pour l'excitation
H01S 3/137 - Stabilisation de paramètres de sortie de laser, p. ex. fréquence ou amplitude par commande de dispositifs placés dans la cavité pour la stabilisation de la fréquence
H01S 3/30 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet utilisant des effets de diffusion, p. ex. l'effet Brillouin ou Raman stimulé
A method of diagnosing tuberculosis in a subject, the method comprising: a) providing a sample obtained from the subject; b) determining the level of at least one protein in the sample, wherein the at least one protein is selected from the group consisting of Transcription termination factor 1, Fetuin-B, Heparin cofactor 2, Alpha- 1- antichymotrypsin, Gamma-glutamyl hydrolase, Plastin-2, low affinity immunoglobulin gamma Fc region receptor III-B, and variants thereof; c) comparing the level of the at least one protein from step b) with a reference level of the at least one protein; and d) using the results from c) to diagnose or determine if the subject has tuberculosis, wherein the reference level of the at least one protein is the level of the at least one protein that is present in an individual that does not have tuberculosis, and wherein the subject is identified as having tuberculosis if the level of the at least one protein from step b) is higher than the reference level of the at least one protein.
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
The present invention is related to compounds, methods, compositions and uses that are able to restore responsiveness to immunotherapy, in particular immune check point inhibitors or anti-cancer vaccine or to anti-angiogenesis treatment.
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61K 31/4025 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil non condensés et contenant d'autres hétérocycles, p. ex. cromakalim
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
A wave absorber device for absorbing energy from an incident wave that is at least partly spatially coherent comprises: a pair of reflective surfaces configured to reflect the incident wave and with an angle between the reflective surfaces of less than 180 degrees, the pair of reflective surfaces arranged to each intercept a different spatial portion of the wavefront of the incident wave and reflect the spatial portion along a direction away from a propagation direction of the incident wave; and an absorber configured to at least partly absorb the incident wave and having two opposite sides, the absorber arranged between the pair of reflective surfaces so as to receive, from the pair of reflective surfaces, a different spatial portion on each of the opposite sides such that the different spatial portions interfere with one another to form a standing wave at the absorber.
A metalens and its method of manufacture, the metalens being designed and fabricated to transform a laser beam into a pre-defined arbitrary optical field carrying spin angular momentum and/or orbital angular momentum in defined directions, which can be transferred to nanoparticles trapped by levitation in the optical field of the laser beam that has passed through the metalens. The metalens can be incorporated into an optical levitation system in which a nanoparticle can be trapped in the arbitrary optical field. Light intensity scattered from the trapped nanoparticle is then measured and used as a basis for measuring a physical field value.
Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
The present invention provides a new method of treating a solid tumour with an ATM (ataxia telangiectasia mutated) inhibitor and/or a CHK2 (checkpoint kinase 2) inhibitor. New therapy combinations, formulations and kits are also provided.
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
A61K 31/427 - Thiazoles non condensés et contenant d'autres hétérocycles
A61K 31/4535 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un hétérocycle avec le soufre comme hétéro-atome du cycle, p. ex. pizotifène
A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
An intervertebral disc prosthesis comprising an annulus (8) and a nucleus (46), the annulus comprising an elastomeric annular body (10) defining a central aperture (18), reinforcing means comprising at least one strand of reinforcing material (30, 32) extending around the central aperture, and two flexible annular endplates (12, 14) located at opposite ends of the annular body (10), each of the endplates comprising fixing means (40) for fixing the disc to a respective vertebra.
The invention provides a non-toxic method for producing cyclic peptides within a mammalian cell, comprising the steps of a) introducing a vector into the mammalian cell, wherein the vector comprises a construct encoding a C-terminus intein domain, a polypeptide sequence to be cyclised, an N-terminus intein domain, and a degradation tag, wherein the degradation tag is attached to at least one intein domain, and b) expressing the construct to produce an intermediate comprising an active intein and the polypeptide sequence, wherein the active intein, once formed, undergoes splicing and cyclises the polypeptide and wherein the degradation tag degrades the active intein. The invention further provides a cyclic peptide library produced according to this method, and the incorporation of the non-toxic cyclic peptide-producing construct of the above method into a genetic construct, a vector, or a mammalian cell.
The invention provides cyclic peptides that are able to disrupt the typical response to hypoxia and which have particular utility in the treatment of cancers and von Hippel-Lindau disease.
A spectrometer comprises a flat optical fibre having a length along a propagation direction for light input into the flat optical fibre, a width orthogonal to the length, a thickness less than the width and orthogonal to the length and the width, an input face bounded by the width and the thickness, and an output face bounded by the width and the length; an input optical fibre optically coupled to the input face to transmit incident light into the flat optical fibre along the propagation direction; and a scattering structure within the flat optical fibre configured to receive and scatter the incident light to create a speckle pattern via interference of the scattered incident light, a component of the speckle pattern being emitted for detection from the flat optical fibre through the output face along a direction orthogonal to the propagation direction.
G01L 1/24 - Mesure des forces ou des contraintes, en général en mesurant les variations des propriétés optiques du matériau quand il est soumis à une contrainte, p. ex. par l'analyse des contraintes par photo-élasticité
A regenerative shock absorber having an input module for receiving input linear vibration. A transmission mechanism having an output shaft, and configured to convert relative linear motion of opposite first and second end parts of the shock absorber into rotational motion of the output shaft. A generator module having a flywheel fitted to the output shaft, and an electromagnetic generator. The output shaft may comprise a self-reversing leadscrew which is rotated in a unidirectional direction of rotation when a clutch mechanism fitted thereto is translationally moved relative to the output shaft in each of opposite first and second linear directions. Alternatively, the output shaft may comprise a single threaded leadscrew. The electromagnetic generator is driven when a clutch mechanism fitted to the output shaft is translationally moved relative to the output shaft in one linear direction, and a second electromagnetic generator fitted to the clutch mechanism is driven when the clutch mechanism is translationally moved relative to the output shaft in the opposite linear direction.
B60G 13/14 - Suspensions élastiques caractérisées par la disposition, l'emplacement ou le type des amortisseurs de vibrations ayant des amortisseurs emmagasinant l'énergie sous une forme utilisable, p. ex. comprimant l'air
H02K 7/02 - Masses additionnelles pour augmenter l'inertie, p. ex. volants
H02K 7/108 - Association structurelle avec des embrayages, des freins, des engrenages, des poulies ou des démarreurs mécaniques avec des embrayages à friction
H02K 7/18 - Association structurelle de génératrices électriques à des moteurs mécaniques d'entraînement, p. ex. à des turbines
22.
METHOD OF DETECTING PHOTONS AND PHOTON DETECTOR ARRANGEMENT
According to embodiments of the present invention, a method of detecting photons is provided. The method includes arranging a plurality of light absorbing elements to interact with an electromagnetic standing wave at a corresponding plurality of points of the electromagnetic standing wave to absorb at least part of the electromagnetic standing wave, the plurality of light absorbing elements being spaced apart from each other, and detecting electrical signals generated in response to the absorption to detect photons corresponding to the electromagnetic standing wave. According to further embodiments of the present invention, a photon detector arrangement is also provided.
A method of making an optical fibre preform comprising providing a hollow outer tube of glass, providing a hollow primary capillary tube of glass with an outer diameter smaller than an inner diameter of the outer tube, positioning the primary capillary tube inside the outer tube such that an outer surface of the primary capillary tube lies against an inner surface of the outer tube along a contact line parallel to the longitudinal axes of the primary capillary tube and the outer tube, and bonding the primary capillary tube into its position inside the outer tube by directing a laser beam onto a surface of the outer tube or the primary capillary at one or more locations aligned with the contact line.
A method of impedance flow cytometry comprises: flowing a fluid along a flow channel; applying electrical signals to current paths through the fluid, the current paths comprising at least first and second current paths, and further first and second current paths, wherein the electrical signals applied to the first and further first current paths have a frequency, magnitude and phase, and the electrical signals applied to the second and further second current paths have substantially equal frequency and magnitude and opposite phase to the electrical signals applied to the first and first further current path; detecting current flow in the current paths; producing a first summed signal representing the sum of the current flows detected in the current paths, and a second summed signal representing the sum of the current flows detected in the further current paths; and obtaining a differential signal representing the difference between the summed signals.
G01N 15/12 - Recherche de particules individuelles en mesurant des effets électriques ou magnétiques en observant des changements de résistance ou d’impédance à travers des fentes traversées par des particules individuelles, p. ex. en utilisant le principe de Coulter
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
25.
MICRORNA BIOMARKERS FOR MULTI CANCER EARLY DETECTION TEST (MCED)
The invention relates to a method of diagnosing a cancer in a subject, wherein the method comprises determining the expression level of a set of miRNAs in a sample obtained from the subject. The invention also relates to a method of identifying the site of localisation of a cancer in a subject. The invention also provides method of treating a subject with cancer.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST (Royaume‑Uni)
Inventeur(s)
Wilkinson, Tom
Bennett, Michael John
Welham, Benjamin
Abrégé
A method is provided for determining a measure of disease in a region of the body of a subject. The method comprises receiving imaging data obtained from imaging the region of the body of the subject comprising data representative of a distribution of a marker within the region administered to the subject prior to the imaging. The marker binds to a biological target related to the disease. The imaging data is processed to obtain a measure of marker signal in the region. The measure of marker signal is corrected for an effect on the marker signal of tissue structure within the region. The measure of the disease is determined for the region using the corrected measure of marker signal. Also provided is an apparatus configured to carry out the method.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
The invention provides cyclic peptides that are able to disrupt the typical response to hypoxia and which have particular utility in the treatment of cancers and von Hippel- Lindau disease.
An integrated reference electrode for use in an electrochemical measurement system, comprising: a reference electrode in combination with a hygroscopic hydrogel electrolyte impregnated and contained in a porous framework, wherein the hygroscopic hydrogel electrolyte is adapted to contact the reference electrode when in a hydrated state. Also, an ion selective membrane with an aromatic epoxy polymer made from one or more monomers having at least one epoxide group, and a chloride salt or a silver—silver chloride physically trapped in the aromatic epoxy polymer. On contact with water the aromatic epoxy polymer forms a network of channels for ion exchange. The membrane may be used between an electrolyte and an external fluid environment; or the membrane may be coated upon the surface of a reference electrode.
A61B 5/1473 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques invasifs, p. ex. introduits dans le corps par un cathéter
G01N 27/333 - Électrodes ou membranes sélectives à l'égard des ions
G01N 27/30 - Électrodes, p. ex. électrodes pour testsDemi-cellules
An electric heating system for heating a fluid flow, the system comprising: a plurality of annular walls composed of an electrically conductive material, the walls being nested to define a plurality of annular flow channels which are serially arranged concentrically about a longitudinal axis, wherein the plurality of annular walls are mechanically connected together whereby adjacent flow channels have opposite fluid flow directions and are connected at adjacent ends of the respective channels to define an alternating serpentine flow path which has an input end at the fluid input and an output end at the fluid output, wherein the input and output ends are respectively located at radially outer and radially inner positions relative to the longitudinal axis.
F24H 3/04 - Appareils de chauffage d'air à circulation forcée l'air étant en contact direct avec l'agent chauffant, p. ex. élément chauffant électrique
B64G 1/40 - Aménagements ou adaptations des systèmes de propulsion
F24H 9/00 - APPAREILS DE CHAUFFAGE DE FLUIDES, p. ex. DE L'AIR OU DE L'EAU, COMPORTANT DES MOYENS DE PRODUCTION DE CHALEUR, p. ex. DES POMPES À CHALEUR, EN GÉNÉRAL Parties constitutives
F24H 9/1863 - Disposition ou montage des éléments chauffants électriques
H05B 3/06 - Éléments chauffants combinés constructivement avec des éléments d'accouplement ou avec des supports
H05B 3/44 - Éléments chauffants ayant la forme de tiges ou de tubes non flexibles le conducteur chauffant disposé à l'intérieur des tiges ou tubes en matériau isolant
H05B 3/78 - Dispositions pour le chauffage spécialement adaptées au chauffage par immersion
31.
MODULATION OF GENE EXPRESSION AND SCREENING FOR DEREGULATED PROTEIN EXPRESSION
Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
An apparatus that displays synthetic scene images for augmented reality, virtual reality and other display types. One or more pairs of input beams (70, 76) are injected into a display panel incorporating a layer (100) of phase matched nonlinear optical (NLO) material. The input beams of each pair are brought to cross each other in the NLO material in a noncollinear geometry to generate a product beam (84) by sum frequency generation that is directed to the eye (160) of a viewer. The synthetic scene image information is impressed on each input beam pair by amplitude and phase modulation to set the amplitude (i.e. brightness), wavevector (i.e. direction) and wavefront radius of curvature (i.e. depth) of the synthetic scene image. For colour display, three pairs of input beams with respective sum frequencies in three primary colours are used.
A hollow core optical waveguide comprises a hollow core; and a structured arrangement of longitudinally extending capillaries surrounding the hollow core to form a cladding; wherein one or both of the hollow core and the cladding contains gas configured to provide a refractive index difference between the hollow core and the cladding.
An optical trap for laser cooling and trapping atoms. Three pairs of laser beams are directed to cross in a vacuum chamber at a common intersection volume, wherein each pair is formed by two counterpropagating beams. Rather than having a mutually orthogonal arrangement in which each beam pair forms an angle χ of 45° to a reference axis, z, these angles are instead between 5°≤χ≤40°. Moreover, in each beam pair, the counterpropagating beams are not precisely aligned in a common path, as in a conventional magneto-optical trap, but are slightly misaligned by respective misalignment angles [α, β, κ] of typically 0.1° to 2°. The misalignment angles and beam widths are however selected so that a common intersection volume for all six beams is maintained. This provides an all-optical trap in which laser cooling and trapping of atoms takes place without a magnetic field being present.
G21K 1/00 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer
G21K 1/06 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant la diffraction, la réfraction ou la réflexion, p. ex. monochromateurs
35.
COMBINED USE OF FC GAMMA RIIB (CD32B) AND CD20 SPECIFIC ANTIBODIES
The invention provides a method of treating a patient having target cells that express FcγRIIb, the method comprising administering (i) an antibody molecule that specifically binds a surface antigen of the target cell, which antibody molecule has an Fc domain capable of binding FcγRIIb; in combination with (ii) an agent that prevents or reduces binding between the Fc domain of the antibody molecule and FcγRIIb; characterized in that the patient is selected on the basis that their target cells express an elevated level of FcγRIIb.
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
36.
COMPOSITIONS FOR CANCER TREATMENT AND METHODS AND USES FOR CANCER TREATMENT AND PROGNOSIS
Global transcriptional profiling of CTLs in tumors and adjacent non-tumor tissue from treatment-naïve patients with early stage lung cancer revealed molecular features associated with robustness of anti-tumor immune responses. Major differences in the transcriptional program of tumor-infiltrating CTLs were observed that are shared across tumor subtypes. Pathway analysis revealed enrichment of genes in cell cycle, T cell receptor (TCR) activation and co-stimulation pathways, indicating tumor-driven expansion of presumed tumor antigen-specific CTLs. Marked heterogeneity in the expression of molecules associated with TCR activation and immune checkpoints such as 4-1BB, PD1, TIM3, was also observed and their expression was positively correlated with the density of tumor-infiltrating CTLs. Transcripts linked to tissue-resident memory cells (TRM), such as CD103, were enriched in tumors containing a high density of CTLs, and CTLs from CD103high tumors displayed features of enhanced cytotoxicity, implying better anti-tumor activity. In an independent cohort of 689 lung cancer patients, patients with CD103high (TRM rich) tumors survived significantly longer. In summary, the molecular fingerprint of tumor-infiltrating CTLs at the site of primary tumor was defined and a number of novel targets identified that appear to be important in modulating the magnitude and specificity of anti-tumor immune responses in lung cancer.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
37.
DRUGS CONJUGATED WITH HEXOSE PHOSPHATE AND METHODS OF MAKING AND USING SAME
A drug conjugate, composition, and method for delivering active antimicrobials based on existing antibiotics through a hexose phosphate transporter (UhpT) by conjugating the antimicrobials with non-metabolizable hexose phosphates. Methods of co-administering antibiotics with non-metabolizable hexose phosphates as antimicrobials are also disclosed. Non-metabolizable hexose phosphates can constitutively and strongly induce expression of UhpT which significantly improves the efficacy and/or antimicrobial spectrum of antibiotics. This drug conjugate, composition and method will permit reuse of many FDA approved antibiotics that have been abandoned or fallen into disuse due to their current low efficacy and/or resistance to these antibiotics by pathogens.
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
An apparatus (102; 202) for transferring heat from a heat source (104) to a fluid when the apparatus (102; 202) is connected to the heat source (104) is disclosed. The apparatus (102; 202) includes a heat sink (106; 206) with a heat sink base (108) and fins (110) extending in a longitudinal direction (112). The heat sink base (108) and the fins (110) form longitudinal channels (114) for streams of the fluid. The apparatus (102) further includes one or more flaps (118) having a longitudinal extension (119) and being located in the longitudinal channels (114). By means of the flaps (118), turbulence is introduced, which enhances mixing of heated fluid (heated by the fins) with the main stream of initially cold fluid through the longitudinal channels (114), whereby the heat transfer efficiency of the heat sink is improved. A network access node for a wireless communication system is also provided, wherein the network access node comprises an apparatus (102; 202) of the above-mentioned sort.
Described is the use of a first antibody molecule that specifically binds Fc RIIB via its Fab region, but lacks Fc region or has reduced binding to Fc receptors via its Fc region, for use in combination with a second antibody molecule that specifically binds to a receptor present on a tumor cell, which second antibody molecule has an Fc region that binds to at least one activating Fc receptor in the treatment of an FcγRIIB-negative cancer in a patient, as well as pharmaceutical compositions and kits comprising these to antibody molecules, and methods of treating cancer using these two antibodies.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
An optical trap for laser cooling and trapping atoms. Three Z pairs of laser beams are directed to cross in a vacuum chamber at a common intersection volume, wherein each pair is formed by two counterpropagating beams. Rather than having a mutually orthogonal arrangement in which each beam pair forms an angle χ of 45° to a reference axis, z, these angles are instead between 5°≤χ≤40°. Moreover, in each beam pair, the counterpropagating beams are not precisely aligned in a common path, as in a conventional magneto-optical trap, but are slightly misaligned by respective misalignement angles [α, β, κ] of typically 0.1° to 2°. The misalignment angles and beam widths are however selected so that a common intersection volume for all six beams is maintained This provides an all-optical trap in which laser cooling and trapping of atoms takes place without a magnetic field being present.
G21K 1/00 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer
G21K 1/06 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant la diffraction, la réfraction ou la réflexion, p. ex. monochromateurs
41.
OPTICAL TIME DOMAIN REFLECTOMETRY FOR HOLLOW CORE OPTICAL FIBRES
A method of assessing an optical system comprising a hollow core optical fibre comprises providing an optical time domain reflectometry system comprising: an optical source configured to generate optical pulses with wavelength λ; an optical detector configured to detect light at wavelength λ; and an input/output fibre comprising a solid core optical fibre optically coupled at a proximal end to receive optical pulses from the optical source and deliver light to the optical detector, and having at its distal end an end facet with an applied treatment configured to suppress back-reflection of light at wavelength λ caused at an interface of glass forming the core of the solid core optical fibre and air at the end facet; aligning the distal end of the input/output fibre with a proximal end of a hollow core optical fibre having gas present in the hollow core, for optical transmission between the input/output fibre and the hollow core optical fibre; operating the optical source to generate optical pulses for propagation along the input/output fibre and into the hollow core fibre; receiving backscattered light produced by Rayleigh scattering of the optical pulses from the gas in the hollow core of the hollow core fibre and detecting the backscattered light with the optical detector to generate a detected signal; and processing the detected signal to create an optical time domain reflectometry profile comprising a distribution of backscattered optical power along a length of the hollow core optical fibre.
Apparatus for use in four wave mixing is disclosed, comprising a nonlinear medium for receiving a plurality of light beams copropagating along an optical path through the nonlinear medium, the plurality of light beams including at least one signal wave having a signal frequency and one or two pump waves having respective pump frequencies, the light beams generating one or more unwanted idler waves in the nonlinear medium. The apparatus further comprises phase adjusting means arranged to selectively apply to wavelengths of light in the nonlinear medium, respective wavelength-dependent phase shifts to adjust the phase difference between the or each pump wave and the signal wave, such that unwanted idler waves are generated along the optical path of the nonlinear medium so as to destructively interfere, suppressing unwanted idler waves at an output of the nonlinear medium. A method of configuring the phase adjusting means is disclosed.
A birefringent optical element for transforming an incident beam of light into two spatially separated output beams of light with orthogonal linear polarizations comprises: a transparent substrate with an input face for receiving the incident beam, an output face, and a uniform thickness between the input face and the output face, the substrate having a non-uniform birefringence in a plane parallel to the input face, the birefringence provided by a plurality of randomly positioned nanostructures within the substrate and configured to cause the incident beam to shear within the substrate into two output beams with orthogonal linear polarisations and wavefronts at an angle to one another so that the output beams leave the output face with a spatial separation along a shear direction parallel to the output face; wherein each nanostructure has an oblate spheroidal shape with an elliptical cross-section in a plane parallel to the input face, the orientation of the elliptical cross-section giving a slow axis orientation of birefringence and a size of the oblate spheroidal shape giving a retardance value of birefringence, the orientation and the size varying between the nanostructures to provide the non-uniform birefringence of the substrate.
A polarized light microscope includes a light source configured to illuminate a specimen and an imaging sensor configured to capture an image of the specimen. The polarized light microscope also includes a first circular polarizer positioned between the light source and the specimen. A birefringent mosaic mask is positioned between the specimen and the imaging sensor. The polarized light microscope also includes a second polarizer positioned between the mask and the imaging sensor.
A flexible elongate atmospheric plasma generator for generating a transverse atmospheric plasma within configured for insertion into an internal channel of an elongate endoscope tube, the plasma generator including an elongate body of dielectric material, an elongate first electrode centrally located within the body of dielectric material and an elongate second electrode around an elongate external surface of the body of dielectric material, the second electrode having a plurality of electrically conductive elements forming a mesh defining holes in the second electrode, wherein application of a potential difference across the first and second electrodes can generate a plasma within atmospheric air surrounding the atmospheric plasma generator.
A61L 2/14 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques du plasma, c.-à-d. des gaz ionisés
A microfluidic culture apparatus for use in an NMR/MRI system. In one arrangement, the apparatus comprises an insertion module and a flow controller. The flow controller drives flow of a culture medium in a first flow line and of a gas in a second flow line. The insertion module comprises a first passage forming at least part of the first flow line, a culture chamber for containing a sample of living tissue, a second passage forming at least part of the second flow line, and a gas exchange arrangement that allows gas to pass from the second passage to the first passage.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
47.
MULTI-EXCITATION RAMAN SPECTROSCOPY METHOD AND APPARATUS
There is provided a method of identifying one or more substances in a sample comprising: illuminating the sample with light of each of a plurality of different excitation modes; measuring an intensity and/or polarisation of light from the sample at a plurality of wavelengths to obtain a measured spectrum for each of the excitation modes; and identifying one or more substances in the sample using the measured spectra together, wherein: the excitation modes differ in one or both of wavelength and polarisation; and the identifying of the one or more substances uses contributions to the measured spectra from a plurality of photophysical processes in the sample including inelastic scattering of light. An apparatus suitable for carrying out the method is also provided.
Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
49.
RAPID SCREEN FOR ANTIBIOTIC RESISTANCE AND TREATMENT REGIMEN
SECRETARY OF STATE FOR HEALTH AND SOCIAL CARE (Royaume‑Uni)
THE UNIVERSITY OF SOUTHAMPTON (Royaume‑Uni)
Inventeur(s)
Sutton, John Mark
Hind, Charlotte
Morgan, Hywel
Spencer, Daniel
Abrégé
Methods are presented which use impedance flow cytometry for rapid susceptibility testing of antimicrobial agents including phage, antimicrobial peptides and rapid analysis of antimicrobial mediated serum bactericidal assays.
This disclosure provides methods of treating autoimmune disease or conditions, inflammatory disease, and/or aberrant immune responses, including asthma and fibrotic disease, in a subject by modulating a population of T-cells that exhibits higher or lower than baseline expression of the one or more genes disclosed herein. In other aspects, methods are provided to diagnose such disease and determine prognosis of such patients. Also provided are methods to identify markers associated with the isolated and/or purified cell populations that elicit a more positive prognosis.
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
G01N 33/564 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes
An optical source comprises: a pump source operable to generate laser light at a first wavelength; a single mode optical fibre arranged to receive laser light at the first wavelength from the pump source, the optical fibre being fabricated from material having a Raman gain profile for stimulated Raman scattering of light at the first wavelength such that received laser light at the first wavelength experiences stimulated Raman scattering within the optical fibre to a second wavelength longer than the first wavelength, and a Brillouin gain profile for stimulated Brillouin scattering of light at the second wavelength to a third wavelength longer than the second wavelength; and a superstructured fibre Bragg grating formed in the optical fibre, the grating comprising: a periodic refractive index profile along a core of the optical fibre, giving transmission of the first wavelength to allow received laser light at the first wavelength to enter the superstructured fibre Bragg grating, reflection of the second wavelength at a first level, and reflection of the third wavelength at a second level lower than the first level; and a phase shift at an intermediate location along a length of the grating to create, via the reflection at the first level, a resonant cavity for the second wavelength that enables light at the second wavelength to reach an intracavity power sufficient for the stimulated Brillouin scattering to occur so that light at the second wavelength undergoes a wavelength shift to the third wavelength until the intracavity power at the second wavelength becomes insufficient for the stimulated Brillouin scattering to occur, the light at the third wavelength coupling out of the resonant cavity, via the reflection at the second level, as a series of pulses corresponding to the intracavity power at the second wavelength being sufficient for the stimulated Brillouin scattering to occur; wherein the series of pulses at the third wavelength comprise a pulsed output of the optical source.
H01S 3/30 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet utilisant des effets de diffusion, p. ex. l'effet Brillouin ou Raman stimulé
H01S 3/102 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande du milieu actif, p. ex. par commande des procédés ou des appareils pour l'excitation
H01S 3/11 - Blocage de modesCommutation-QAutres techniques d'impulsions géantes, p. ex. vidange de cavité
H01S 3/094 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique par de la lumière cohérente
H01S 3/106 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité
H01S 3/0941 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique par de la lumière cohérente produite par un laser à semi-conducteur, p. ex. par une diode laser
H01S 3/137 - Stabilisation de paramètres de sortie de laser, p. ex. fréquence ou amplitude par commande de dispositifs placés dans la cavité pour la stabilisation de la fréquence
The present disclosure provides antisense compounds, methods, and compositions for silencing ADAM33 mRNA. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with ADAM33 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with ADAM33.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
53.
Method and apparatus for obtaining chemical and/or material specific information of a sample using light scattered by Rayleigh scattering and/or Raman scattering
A method for obtaining chemical and/or material specific information of a sample based on scattered light. The method comprises receiving detection data comprising at least two images. Each image is indicative of the intensity of scattered light i) for incident light of a different wavelength, or ii) for incident light of a different polarization state, or iii) of a different polarization state. The scattered light comprises an elastic scattering component that is due to Rayleigh scattering of the incident light in at least a portion of the sample. Alternatively, each image is indicative of the intensity of scattered light i) of a different wavelength, or ii) for incident light of a different polarization state, or iii) of a different polarization state, wherein the scattered light comprises an inelastic scattering component that is due to Raman scattering of the incident light in at least a portion of the sample. The method further comprises determining the chemical and/or material specific information of the sample based on the change in intensity of the elastic scattering component in dependence on the change in wavelength and/or the change in polarization state of the incident and/or scattered light.
Described are anti-LILRB3 antibody molecules, such as agonistic anti-LILRB3 antibody molecules for use in treatment of graft rejection or autoimmunity via reprograming of human myeloid cells. Described are also specific anti-LILRB3 antibody molecules and use of such antibody molecules in medicine, for example in treatment of graft rejection, autoimmune disorders or inflammatory disorders.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
The invention relates to a hybrid solid-liquid electrolyte comprising a solid electrolyte and a liquid electrolyte, wherein the solid electrolyte contacts the liquid electrolyte to form a solid/liquid electrolyte interphase, and wherein the liquid electrolyte comprises: at least one organic solvent; at least one salt; and an additive, wherein the additive comprises water, and wherein the areal resistance at the solid/liquid electrolyte interphase of the hybrid solid-liquid electrolyte is reduced relative to the areal resistance at the solid/liquid electrolyte interphase of an equivalent hybrid solid-liquid electrolyte in which the liquid electrolyte does not comprise the additive.
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
H01M 10/056 - Accumulateurs à électrolyte non aqueux caractérisés par les matériaux utilisés comme électrolytes, p. ex. électrolytes mixtes inorganiques/organiques
H01M 10/42 - Procédés ou dispositions pour assurer le fonctionnement ou l'entretien des éléments secondaires ou des demi-éléments secondaires
56.
Method and apparatus for instruction checkpointing in a data processing device powered by an unpredictable power source
A method and apparatus generate computer executable code as one or more code portions, detect a number of processing operations required to reach one or more predetermined stages in execution of each code portion, and associate with each code portion one or more progress indicators, each representing a respective execution stage of the one or more predetermined stages within execution of that code portion. Further aspects include, when a current execution stage of the program code is at least at the execution stage represented by the progress indicator, a first operation may be performed, and when the current execution stage of the program code is before the execution stage represented by the progress indicator, a second operation different from the first operation is performed.
G06F 1/3228 - Surveillance d’exécution de tâches, p. ex. par utilisation de temporisations d’attente, de commandes d’arrêt ou de commandes d’attente
G06F 1/30 - Moyens pour agir en cas de panne ou d'interruption d'alimentation
G06F 1/3212 - Surveillance du niveau de charge de la batterie, p. ex. un mode d’économie d’énergie étant activé lorsque la tension de la batterie descend sous un certain niveau
G06F 1/3296 - Économie d’énergie caractérisée par l'action entreprise par diminution de la tension d’alimentation ou de la tension de fonctionnement
G06F 11/14 - Détection ou correction d'erreur dans les données par redondance dans les opérations, p. ex. en utilisant différentes séquences d'opérations aboutissant au même résultat
An optical reflector device comprises: two or more device elements, each device element comprising: an antenna element configured to receive and re-emit incident light; a half-length phase shifter optically coupled to the antenna element and configured to apply a first half of a phase shift to light received by the antenna element; and a reflector arranged to receive the light from the phase shifter and redirect it back through the phase shifter for the phase shifter to apply a second half of the phase shift to the light before the light is re-emitted by the antenna element; wherein: the antenna elements are arranged in a matrix such that each antenna element receives a portion of a light beam incident on the matrix, the portions combining into a reflected light beam when re-emitted from the antenna elements; and the phase shifters are configured to be controllable such that the phase shifter of each device element applies a different phase shift to the portion of the light beam in the device element, the phase shifts selectable to provide an angle of propagation for the reflected light beam defined by constructive interference of the re-emitted portions of the light beam.
H04Q 11/00 - Dispositifs de sélection pour systèmes multiplex
G02F 1/315 - Dispositifs de déflexion numérique basés sur une réflexion totale interne commandée
G02F 1/225 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur par interférence dans une structure de guide d'ondes optique
58.
METHOD AND APPARATUS FOR OPTICAL PULSE SEQUENCE GENERATION
A method of generating multiple channels of optical pulses comprises: providing a continuous wave optical input having an optical power; dividing the optical power of the optical input into equal consecutive slices in the time domain; and allocating the consecutive slices sequentially to two or more optical outputs such that each output forms a channel of optical pulses of equal pulse repetition rate shifted in time relative to the or each other channel.
An optical modulator. The optical modulator comprising: a micro-ring resonator; and a bus waveguide, including an input waveguide region, an output waveguide region, and a coupling waveguide region optically coupled to the micro-ring resonator and located between the input waveguide region and the output waveguide region. The micro-ring resonator includes a modulation region, the modulation region being formed of a silicon portion and a III-V semiconductor portion separated by a crystalline rare earth oxide dielectric layer.
G02F 1/025 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments à semi-conducteurs ayant des barrières de potentiel, p. ex. une jonction PN ou PIN dans une structure de guide d'ondes optique
G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur
A method of manufacturing a photonic chip. The method comprises providing a wafer comprising a silicon substrate, and a low refractive index layer above the silicon substrate, forming a first trench having a first height and a second trench having a second height by etching the low refractive index layer. The second height is greater than the first height and the second trench has a bottom surface that is closer to the substrate than a bottom surface of the first trench.
G02B 6/122 - Éléments optiques de base, p. ex. voies de guidage de la lumière
G02B 6/13 - Circuits optiques intégrés caractérisés par le procédé de fabrication
G02B 6/132 - Circuits optiques intégrés caractérisés par le procédé de fabrication par le dépôt de couches minces
G02B 6/136 - Circuits optiques intégrés caractérisés par le procédé de fabrication par gravure
G02B 6/12 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
61.
SUPPRESSIVE T CELL POPULATIONS AND METHODS OF CANCER IMMUNOTHERAPY
FRFR), ST2 Treg, highly suppressive Treg, activated Treg, or effector Treg cells in the sample; (c) comparing the at least one level or activity of the T cells in the sample to a level or activity of the T cells in a reference sample, respectively, for a specific tumor type or a healthy subject; and (d) if the patient has the at least one of the high level or activity of the T cells systemically as compared to the reference sample, then administering a cancer therapy to the patient that comprises a modified dosage or administration of a Phosphoinositide 3 -kinase (PI3K) inhibitor.
Regenerative Shock Absorber A regenerative shock absorber comprises an input module for receiving input linear vibration. A transmission mechanism comprises an output shaft, and is configured to convert relative linear motion of opposite first and second end parts of the shock absorber into rotational motion of the output shaft. A generator module comprises a flywheel fitted to the output shaft, and an electromagnetic generator. The output shaft may comprise a self-reversing leadscrew which is rotated in a unidirectional direction of rotation when a clutch mechanism fitted thereto is translationally moved relative to the output shaft in each of opposite first and second linear directions. Alternatively, the output shaft may comprise a single threaded leadscrew. The electromagnetic generator is driven when a clutch mechanism fitted to the output shaft is translationally moved relative to the output shaft in one linear direction, and a second electromagnetic generator fitted to the clutch mechanism is driven when the clutch mechanism is translationally moved relative to the output shaft in the opposite linear direction.
F16F 7/10 - Amortisseurs de vibrationsAmortisseurs de chocs utilisant un effet d'inertie
F16F 15/03 - Suppression des vibrations dans les systèmes non rotatifs, p. ex. dans des systèmes alternatifsSuppression des vibrations dans les systèmes rotatifs par l'utilisation d'organes ne se déplaçant pas avec le système rotatif utilisant des moyens électromagnétiques
An energy harvesting device comprises an input module for receiving input linear vibration. A transmission mechanism comprises an output shaft, and is configured to convert relative linear motion of opposite first and second end parts of the energy harvesting device into rotational motion of the output shaft. A generator module comprises a flywheel fitted to the output shaft, and an electromagnetic generator. The output shaft may comprise a self-reversing leadscrew which is rotated in a unidirectional direction of rotation when a clutch mechanism fitted thereto is translationally moved relative to the output shaft in each of opposite first and second linear directions. Alternatively, the output shaft may comprise a single threaded leadscrew. The electromagnetic generator is driven when a clutch mechanism fitted to the output shaft is translationally moved relative to the output shaft in one linear direction, and a second electromagnetic generator fitted to the clutch mechanism is driven when the clutch mechanism is translationally moved relative to the output shaft in the opposite linear direction. The energy harvesting device may comprise a flywheel having a variable moment of inertia which varies the resonant frequency of the energy harvesting device to broaden the operating bandwidth of the energy harvesting device.
H02K 7/06 - Moyens de transformation d'un mouvement alternatif en un mouvement circulaire ou vice versa
H02K 7/18 - Association structurelle de génératrices électriques à des moteurs mécaniques d'entraînement, p. ex. à des turbines
F03B 13/18 - Utilisation du mouvement relatif entre un élément déplacé par les vagues et un autre élément l'autre élément étant fixé, à au moins un point, par rapport au fond ou au bord de la mer
64.
METHOD OF DETECTING PHOTONS AND PHOTON DETECTOR ARRANGEMENT
According to embodiments of the present invention, a method of detecting photons is provided. The method includes arranging a plurality of light absorbing elements to interact with an electromagnetic standing wave at a corresponding plurality of points of the electromagnetic standing wave to absorb at least part of the electromagnetic standing wave, the plurality of light absorbing elements being spaced apart from each other, and detecting electrical signals generated in response to the absorption to detect photons corresponding to the electromagnetic standing wave. According to further embodiments of the present invention, a photon detector arrangement is also provided.
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (USA)
UNIVERSITY OF SOUTHAMPTON (Royaume‑Uni)
Inventeur(s)
Vijayanand, Pandurangan
Ottensmeier, Christian
Eschweiler, Simon
Abrégé
The present invention includes methods of detecting follicular regulatory T cells (TFR) comprising: obtaining a biological sample from a subject and detecting whether TFR are increased in the tumor sample by contacting the biological sample with antibodies that detect CD3+CD4+ FOXP3+BCL6+ T cells CD3+CD4+CXCR5+GITR+ T cells, or both, when compared to a healthy subject, and detecting the increase of TFR in the tumor sample. The present invention also includes combination therapy that depletes follicular regulatory T cells (TFR) with minimal effect on regulatory T cells (TREGS) to prevent or reduce immune related adverse effects (irAEs).
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
Methods, systems, apparatuses and computer readable media are provided for characterizing a molecular phenotype of a biological sample using a biological interaction network. A biological interaction network includes a plurality of nodes, each node associated with a corresponding gene or protein. A method includes associating, with each node of the biological interaction network, a corresponding differential abundance value for the gene or protein to which that node corresponds, the differential abundance value derived from a comparison of a representative abundance value for the gene or protein in a biological sample exhibiting the molecular phenotype and a reference abundance value for the gene or protein. The method includes, using the differential abundance values of the nodes of the biological interaction network, performing a hill-climbing algorithm to partition the biological interaction network into clusters. The method includes determining, from the topology of the clusters, a signature of the molecular phenotype.
G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
An optical fiber has corrugations on an outer surface to dissipate a portion of an input light beam, allowing the remaining portion of the light beam to be coupled to the optical fiber. By dissipating the portion of input light, damage to the optical fiber by uncoupled light is reduced.
A nested anti-resonant nodeless hollow core fiber (NANF) enables transmission of multi-kilowatt, continuous wave (CW) light beams operating in wavelengths between 1050 nm and 1100 nm provided by single mode lasers. Such a NANF has little loss over kilometer ranges, and can be employed in long distance subsurface applications, such as in the petroleum industry.
A method for fabricating an optical waveguide comprises: providing a sample of lithium niobate doped with magnesium oxide and having at least one grating of periodic domain inversion defined therein; applying a layer of metallic zinc to a surface of the sample over the at least one grating using sputter deposition; heating the sample in an atmosphere of pure oxygen to cause the zinc to indiffuse into the lithium niobate to form a waveguiding layer of increased refractive index under the surface of the sample; and using a dicing blade to cut two substantially parallel channels along a length direction of the at least one grating, to define a ridge waveguide between the two channels.
G02F 1/377 - Optique non linéaire pour la génération de l'harmonique deux dans une structure de guide d'ondes optique
B26D 3/12 - Fente des portions du pourtour de la pièce, c.-à-d. formation d'entailles sans enlèvement de matière, pour former un certain angle, p. ex. un angle droit, avec le bord de la pièce
A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A catheter (100) for retrieving a cardiovascular device from within a blood vessel, the catheter (100) comprising: a retrieval module (115) configured to magnetically engage a cardiovascular device within the blood vessel (10) so as to disengage the cardiovascular device from the blood vessel for retrieval from within the blood vessel (10) using the catheter (100).
The present invention provides a series of tripeptides according to the compound of formula (I) that inhibit the interaction of both HIF-1α and HIF-2α with HIf-1 β by binding to the PAS-B domain of the α subunit of HIF. The tripeptides and methods disclosed herein are useful in treating diseases or conditions that involve the response to hypoxia.
A method of fabricating an optical element includes providing a substrate of a transparent material in which is to be formed a plurality of birefringent nanostructures spaced apart; generating from the output of a source of femtosecond laser pulses a laser beam group comprising a plurality of focused seeding beams having a circular polarisation; directing the laser beam group onto the surface of the substrate at a first position and applying one or more femtosecond laser pulses from each beam to corresponding volumes in the substrate; repeatedly translating the laser beam group relative to the substrate parallel to the line of seeding beams; translating the laser beam group relative to the substrate and repeating the repeated translation and application of the femtosecond laser pulses; wherein the relative translation of the laser beam group and the substrate aligns the writing beam with successive corresponding volumes.
G11B 7/09 - Dispositions ou montage des têtes ou des sources lumineuses par rapport aux supports d'enregistrement comportant des dispositions pour déplacer le rayon lumineux ou son plan focal dans le but de maintenir l'alignement relatif du rayon lumineux et du support d'enregistrement pendant l'opération de transduction, p. ex. pour compenser les irrégularités de surface ou pour suivre les pistes du support
C03C 23/00 - Autres traitements de surface du verre, autre que sous forme de fibres ou de filaments
A method of imaging comprises: generating a superoscillatory field from coherent electromagnetic radiation; placing an object in the superoscillatory field; detecting one or more intensity distributions of the superoscillatory field scattered by the object; and determining at least one characteristic of the object from the one or more intensity distributions.
G06V 10/145 - Éclairage spécialement adapté à la reconnaissance de formes, p. ex. utilisant des réseaux
G06V 10/147 - Détails de capteurs, p. ex. lentilles de capteurs
G06V 10/774 - Génération d'ensembles de motifs de formationTraitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source méthodes de Bootstrap, p. ex. "bagging” ou “boosting”
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 20/66 - Colifichets, p. ex. boutons de chemise ou bijoux
Described is the combined use of a first antibody molecule that specifically binds FcyRIIb via its Fab region and that binds an Fey receptor via its Fc region, and a second antibody molecule that specifically binds PD-1 and that binds at least one Fey receptor via its Fc region, in the treatment of cancer in a patient having tumor infiltrating T lymphocytes with a medium or high PD-1 expression, as well as pharmaceutical compositions and kits comprising these two antibody molecules, and methods of treating cancer using these two antibodies. Described is also a diagnostic test for identification of patients benefitting from the treatment described herein.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A semiconductor device for use in an optoelectronic integrated circuit; the device comprising: a group four substrate, a waveguide, and a group III/V multilayer stack; wherein the group III/V multilayer stack comprises a quantum component for producing light for the waveguide; wherein the waveguide comprises a material with a deposition temperature below 550 degrees Celsius and a refractive index of any value between 1.3 and 3.8.
H01S 5/343 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH] dans des composés AIIIBV, p. ex. laser AlGaAs
G02B 6/12 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
G02B 6/13 - Circuits optiques intégrés caractérisés par le procédé de fabrication
H01S 5/02 - Détails ou composants structurels non essentiels au fonctionnement laser
H01S 5/026 - Composants intégrés monolithiques, p. ex. guides d'ondes, photodétecteurs de surveillance ou dispositifs d'attaque
H01S 5/34 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH]
77.
METHODS OF OPTICAL DETECTION AND OPTICAL DETECTION APPARATUS
A method of optical detection comprises arranging a optical transmission channel to propagate photons as a single channel of information; and detecting an optical output from the optical transmission channel, the optical output comprising the photons carrying the single channel of information only, using an optical detector comprising a plurality of single photon detector elements arranged in a spatial array, each single photon detector element producing an output, the outputs of all the plurality of single photon detector elements being combined into a detector output for the optical detector.
G01K 11/32 - Mesure de la température basée sur les variations physiques ou chimiques, n'entrant pas dans les groupes , , ou utilisant des changements dans la transmittance, la diffusion ou la luminescence dans les fibres optiques
G01K 11/324 - Mesure de la température basée sur les variations physiques ou chimiques, n'entrant pas dans les groupes , , ou utilisant des changements dans la transmittance, la diffusion ou la luminescence dans les fibres optiques utilisant la diffusion Raman
G01J 1/42 - Photométrie, p. ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
G06N 10/00 - Informatique quantique, c.-à-d. traitement de l’information fondé sur des phénomènes de mécanique quantique
A resonator modulator for modulating light in a photonic circuit, the modulator comprising: a capacitor formed of a ring-shaped insulating region sandwiched between an outer conductive region and an inner conductive region, wherein at least one of the outer conductive regions or the inner conductive regions is a polycrystalline semiconductor material.
G02F 1/025 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments à semi-conducteurs ayant des barrières de potentiel, p. ex. une jonction PN ou PIN dans une structure de guide d'ondes optique
A resonator modulator (10) for modulating light in a photonic circuit, the modulator comprising: a capacitor formed of a ring-shaped insulating region (102) sandwiched between an outer conductive region (101a) and an inner conductive region (101b), wherein at least one of the outer (101a) conductive regions or the inner conductive regions (101b) is a polycrystalline semiconductor material.
G02F 1/025 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments à semi-conducteurs ayant des barrières de potentiel, p. ex. une jonction PN ou PIN dans une structure de guide d'ondes optique
The present invention relates to nucleic acid vaccines which encode at least a MAGED4B protein, for use in the treatment of cancer in particular. Synergistic combinations with other anti-cancer agents are described, particularly immune checkpoint inhibitors. The cancer vaccine may further comprise an immunologically active fragment to enhance the immune response, and an additional cancer antigen, such as FJX1. Particular combination therapies of interest include immunotherapies, radiotherapy, targeted therapies and chemotherapies.
A computer-implemented method for creating encoded data for use in a cognitive computing system. The method comprises the steps of receiving a plurality of hypervectors, each representing a respective semantic object; element-wise modular addition of two or more of the plurality of hypervectors, thereby binding the corresponding semantic objects; and vector concatenation of two or more of the plurality of hypervectors, thereby superposing the corresponding semantic objects. The method may be carried out by a cognitive processing unit that may be part of a cognitive computing system.
G06N 3/063 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques
G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
The invention provides a photonic chip comprising: a silicon substrate, an low refractive index layer above the silicon substrate, and a tapered waveguide above the low refractive index layer, the tapered waveguide having a first height at a first end of the tapered waveguide and a second height at a second end of the tapered waveguide, the second height being greater than the first height, and the tapered waveguide having a bottom surface that is closer to the substrate at the second end than at the first end. The invention further provides a method of manufacturing a photonic chip, the method comprising: providing a wafer comprising a silicon substrate, and an low refractive index layer above the silicon substrate, etching the low refractive index layer to form a tapered trench having a first height at a first end of the tapered trench and a second height at a second end of the tapered trench, the first second height being greater than the second first height, and the tapered trench having a bottom surface that is closer to the substrate at the first second end than at the second first end, and forming a tapered waveguide in the tapered trench.
G02B 6/12 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
G02B 6/122 - Éléments optiques de base, p. ex. voies de guidage de la lumière
G02B 6/13 - Circuits optiques intégrés caractérisés par le procédé de fabrication
G02B 6/132 - Circuits optiques intégrés caractérisés par le procédé de fabrication par le dépôt de couches minces
G02B 6/136 - Circuits optiques intégrés caractérisés par le procédé de fabrication par gravure
The invention relates to a method for producing cartilage from pluripotent stem cells (PSCs), the method comprising providing chondrocytes by: 1) providing pluripotent stem cells (PSCs); 2) inducing differentiation of the PSCs into a primitive streak/mesendoderm by culturing the PSCs in hypoxic conditions, in a (mesendodermic) culture media comprising: i) a Wingless/Integrated (WNT) family member, ii) an Activin family member, and iii) a Fibroblast Growth Factor (FGF) family member; 3) inducing differentiation of the primitive streak/mesendoderm into a mesoderm by culturing the primitive streak/mesendoderm in hypoxic conditions, in a (mesodermic) culture media comprising: i) a FGF family member, ii) a bone morphogenetic protein (BMP) family member, iii) Follistatin, and iv) a Neurotrophin (NT); and 4) inducing differentiation of the mesoderm into chondrocytes by culturing the mesoderm in hypoxic conditions, in a (chondroinductive) culture media comprising: i) a FGF family member, ii) a BMP family member, iii) a Neurotrophin, and iv) a Growth/Differentiation Factor (GDF) family member; and forming a pellet of the chondrocytes and culturing the pellet of the chondrocytes in a culture media under hypoxic conditions to produce the cartilage. The invention further relates to methods of chondrocyte production, synthetically produced cartilage, and use in therapy.
C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
84.
Antiresonant hollow core fibre, preform therefor and method of fabrication
A shaped tube (50,51) for use as a component in the fabrication of an antiresonant hollow core optical fibre, the shaped tube having a side wall with a transverse cross-sectional shape comprising a number of major curved portions (52) alternating with the same number of minor substantially straight portions (54), each curved portion (52) having an inwardly curving shape, and each straight portion (54) being equidistant from a central longitudinal axis of the shaped tube (50,51).
An integrated reference electrode for use in an electrochemical measurement system, comprising: a reference electrode in combination with a hygroscopic hydrogel electrolyte impregnated and contained in a porous framework, wherein the hygroscopic hydrogel electrolyte is adapted to contact the reference electrode when in a hydrated state. Also, an ion selective membrane with an aromatic epoxy polymer made from one or more monomers having at least one epoxide group, and a chloride salt or a silver - silver chloride physically trapped in the aromatic epoxy polymer. On contact with water the aromatic epoxy polymer forms a network of channels for ion exchange. The membrane may be used between an electrolyte and an external fluid environment; or the membrane may be coated upon the surface of a reference electrode.
A61B 5/1468 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
An electric heating system for heating a fluid flow, the system comprising: a housing having an inlet for a fluid flow to be heated by the electric heating system and an outlet for the fluid flow which has been heated by the electric heating system; and a resistive heater mounted within the housing. The resistive heater comprises a fluid input and a fluid output which are fluidically coupled, respectively, to the inlet and the outlet, a plurality of annular walls composed of an electrically conductive material, the walls being nested to define a plurality of annular flow channels which are serially arranged concentrically about a longitudinal axis, wherein the walls extend between opposite first and second ends of the resistive heater which are mutually separated along the longitudinal axis, and first and second electrical terminals for connection to a source of electrical energy to heat the walls of the resistive heater, the first and second electrical terminals being electrically connected to respective first and second walls which are mutually adjacent and comprise an outer pair of the walls which are located at a radially outer side of the resistive heater. The plurality of annular walls are mechanically connected together whereby adjacent flow channels have opposite fluid flow directions and are connected at adjacent ends of the respective channels to define an alternating serpentine flow path which has an input end at the fluid input and an output end at the fluid output, wherein the input and output ends are respectively located at radially outer and radially inner positions relative to the longitudinal axis. The plurality of annular walls are electrically connected together to define a continuous electrically conductive path extending between the first and second electrical terminals, the conductive path having a first part which extends from the first wall to a centre of the resistive heater and a second part which extends from the centre of the resistive heater to the second wall. Also disclosed is a method of producing a high-temperature fluid flow using the electric heating system.
H05B 3/78 - Dispositions pour le chauffage spécialement adaptées au chauffage par immersion
F24H 3/04 - Appareils de chauffage d'air à circulation forcée l'air étant en contact direct avec l'agent chauffant, p. ex. élément chauffant électrique
F24H 9/00 - APPAREILS DE CHAUFFAGE DE FLUIDES, p. ex. DE L'AIR OU DE L'EAU, COMPORTANT DES MOYENS DE PRODUCTION DE CHALEUR, p. ex. DES POMPES À CHALEUR, EN GÉNÉRAL Parties constitutives
F24H 9/1863 - Disposition ou montage des éléments chauffants électriques
F02K 9/00 - Moteurs-fusées, c.-à-d. ensembles fonctionnels portant à la fois le combustible et son oxydantLeur commande
The invention provides cyclic peptides that are able to disrupt the typical response to hypoxia and which have particular utility in the treatment of cancers and von Hippel-Lindau disease.
A hollow core optical fibre comprises a tubular jacket; a cladding comprising a plurality of primary capillaries spaced apart from one another in a ring and each bonded to an inner surface of the jacket at a peripheral location around the circumference of the jacket; and a hollow core formed by a central void within the ring of primary capillaries; wherein the cladding further comprises, within each primary capillary, two secondary capillaries and no more, the two secondary capillaries spaced apart from one another and each bonded to an inner surface of the primary capillary at an azimuthal location around the circumference of the primary capillary which is displaced from the peripheral location of the primary capillary.
An optical trap for laser cooling and trapping atoms. Three pairs of laser beams are directed to cross in a vacuum chamber at a common intersection volume, wherein each pair is formed by two counterpropagating beams. Rather than having a mutually orthogonal arrangement in which each beam pair forms an angle χ of 45° to a reference axis, z, these angles are instead between 5° ≤ χ ≤ 40°. Moreover, in each beam pair, the counterpropagating beams are not precisely aligned in a common path, as in a conventional magneto-optical trap, but are slightly misaligned by respective misalignement angles [α, β, κ] of typically 0.1° to 2°. The misalignment angles and beam widths are however selected so that a common intersection volume for all six beams is maintained. This provides an all-optical trap in which laser cooling and trapping of atoms takes place without a magnetic field being present.
An optical modulation system comprises a signal source configured to generate an amplitude modulated electrical signal having a bandwidth and divided into frequency components comprising at least a first frequency component covering a first portion of the bandwidth and a second frequency component covering a second portion of the bandwidth; and an electro-optic modulator for receiving an input optical signal, the modulator having a first optical path and a second optical path, the input optical signal being divided between the first optical path and the second optical path and recombined after propagation along the first optical path and the second optical path to produce an output optical signal, and at least one of the first optical path and the second optical path comprising a phase shifter comprising a pair of electrodes in which each electrode is configured to receive a driving signal; wherein the or each phase shifter is coupled to the signal source to receive at least one of said frequency components as a driving signal for an electrode, and the phase shifters are arranged such that the or each phase shifter receives a different pair of driving signals.
H04B 10/2513 - Dispositions spécifiques à la transmission par fibres pour réduire ou éliminer la distorsion ou la dispersion due à la dispersion chromatique
H04B 10/079 - Dispositions pour la surveillance ou le test de systèmes de transmissionDispositions pour la mesure des défauts de systèmes de transmission utilisant un signal en service utilisant des mesures du signal de données
91.
METHOD FOR FABRICATING NANOSTRUCTURED OPTICAL ELEMENTS
A method of fabricating an optical element comprises: providing a substrate of a transparent material; applying a plurality of circularly polarised focused femtosecond laser pulses to a volume within the substrate to create substantially spherical nanopores in the volume; and applying at least one and not more than ten non-circularly polarised focused femtosecond laser pulses to the volume to transform the spherical nanopores into oblate spheroidal nanopores.
B23K 26/55 - Travail par transmission du faisceau laser à travers ou dans la pièce à travailler pour créer des vides dans la pièce à travailler, p. ex. pour former des passages ou des configurations de flux
G11C 13/04 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou utilisant des éléments optiques
B23K 26/0622 - Mise en forme du faisceau laser, p. ex. à l’aide de masques ou de foyers multiples par commande directe du faisceau laser par impulsions de mise en forme
B23K 26/00 - Travail par rayon laser, p. ex. soudage, découpage ou perçage
The invention relates to a method of treatment or prophylaxis of cancer, wherein the cancer overexpresses exportin-1, the method comprising the administration of: a peptide capable of activating NK cell-mediated immunity to cancer cells that overexpress exportin-1, the peptide comprising or consisting of the amino acid sequence XnAX2X1, wherein Xn is an amino acid sequence of between 5 and 12 residues, and X1 is any amino acid; or leucine or phenylalanine; and X2 is alanine, threonine or serine; or administration of one or more of a nucleic acid encoding the peptide; an immunogenic composition comprising the peptide; a complex comprising the peptide; a vesicle comprising the peptide or nucleic acid encoding the peptide; a dendritic cell comprising the peptide and/or comprising nucleic acid encoding the peptide; an activated NK cell, that has been activated by the peptide; or a virus or virus like particle comprising the peptide and/or comprising nucleic acid encoding the peptide.
The invention relates to a method for assembling a clay-nanoparticle gel suitable for loading with one or more molecule species such that they are spatially structured therein, and a method for forming a clay-nanoparticle gel comprising one or more spatially structured molecule species. The invention further relates to structured clay nanoparticle gel and their use, for example in treatment.
A61L 27/44 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
A61K 38/18 - Facteurs de croissanceRégulateurs de croissance
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 31/4188 - 1,3-Diazoles condensés avec des systèmes hétérocycliques, p. ex. biotine, sorbinil
A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
94.
HOLLOW CORE OPTICAL WAVEGUIDES AND METHODS FOR MODIFICATION THEREOF
A hollow core optical waveguide comprises a hollow core; and a structured arrangement of longitudinally extending capillaries surrounding the hollow core to form a cladding; wherein one or both of the hollow core and the cladding contains gas configured to provide a refractive index difference between the hollow core and the cladding.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
ETAT FRANÇAIS, SERVICE DE SANTÉ DES ARMÉES REPRÉSENTÉ PAR LE DÉLÉGUÉ GÉNÉRAL DE L'ARMEMENT (France)
UNIVERSITÉ DE STRASBOURG (France)
UNIVERSITY OF SOUTHAMPTON (Royaume‑Uni)
Inventeur(s)
Baati, Rachid
Brown, Richard
Dias, José
Maryan-Instone, Alex
Nachon, Florian
Yerri, Jagadeesh
Voros, Camille
Abrégé
The present invention relates to a compound of formula (I). It also relates to a pharmaceutical composition comprising at least one compound of formula (I) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and/or respiratory failure due to intoxication with at least one organophosphorous nerve agent; in the treatment of neurological diseases such as Alzheimer's disease; and/or in the treatment of cancer.
C07D 213/65 - Un atome d'oxygène lié en position 3 ou 5
C07D 401/06 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Compounds of general formula (1):
Compounds of general formula (1):
Compounds of general formula (1):
wherein R1, R2 and R3 are as defined herein;
are of use in the treatment and prevention of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease.
C07J 9/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de plus de deux atomes de carbone, p. ex. cholane, cholestane, coprostane
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07J 31/00 - Stéroïdes normaux contenant un ou plusieurs atomes de soufre n'appartenant pas à un hétérocycle
C07J 43/00 - Stéroïdes normaux ayant un hétérocycle contenant de l'azote non condensé ou condensé en spiro avec le squelette du cyclopenta[a]hydrophénanthrène
C07J 33/00 - Stéroïdes normaux ayant un hétérocycle contenant du soufre non condensé ou condensé en spiro avec le squelette du cyclopenta[a]hydrophénanthrène
Impedance flow cytometry apparatus comprises: a flow channel for carrying a flow of fluid comprising particles suspended in an electrolyte from an inlet to an outlet; a first electrode group and a second electrode group, each electrode group providing first and second current paths through fluid flowing in the flow channel; wherein each electrode group comprises: a first signal electrode to provide to the first current path a first electrical signal of frequency, magnitude and phase; a second signal electrode to provide to the second current path a second electrical signal of substantially equal frequency and magnitude as the first electrical signal and of opposite phase to the first electrical signal; and one or more measurement electrodes to detect current flow in the first current path and the second current path and produce a summed signal representing the sum of the current flow in the first current path and the current flow in the second current path; wherein the first electrode group produces a first summed signal and the second electrode group produces a second summed signal; and circuitry to determine a differential signal representing the difference between the first summed signal and the second summed signal.
A method of antimicrobial susceptibility testing comprises: preparing samples of microorganisms suspended in an electrolyte, comprising a first sample of the microorganisms unexposed to antimicrobial agents and a second sample of the microorganisms exposed to an antimicrobial agent; passing the first sample through an impedance flow cytometer to obtain a first impedance signal representing one or more components of impedance values of the unexposed microorganisms; passing the second sample through the impedance flow cytometer to obtain a second impedance signal representing one or more components of the impedance values of the exposed microorganisms; comparing the first impedance signal and the second impedance signal; and determining a susceptibility of the microorganisms to the antimicrobial agent based on any differences between the first impedance signal and second impedance signal.
G01N 15/12 - Recherche de particules individuelles en mesurant des effets électriques ou magnétiques en observant des changements de résistance ou d’impédance à travers des fentes traversées par des particules individuelles, p. ex. en utilisant le principe de Coulter
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 15/0227 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’imagerieRecherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’holographie
G01N 15/10 - Recherche de particules individuelles
G01N 15/1031 - Recherche de particules individuelles en mesurant des effets électriques ou magnétiques
99.
METHODS AND COMPOSITONS FOR MODULATIONS OF IMMUNE RESPONSE
Disclosed herein are isolated follicular helper T cell (TFH) and engineered follicular helper T cell (TFH) and methods of isolating or engineering such cells. Further disclosed herein are methods of using such cells for treating diseases, such as cancer.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilized to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.
C07F 5/00 - Composés contenant des éléments des groupes 3 ou 13 du tableau périodique
C07D 255/02 - Composés hétérocycliques contenant des cycles comportant trois atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par les groupes non condensés avec d'autres cycles
