Abrégé

A wearable sensing device (120) and associated method are provided for determining whether or not a drink (112) has been spiked. The sensing device (120) includes a sensor (310) for holding against a container (110) including the drink (112). The sensor (310) includes at least first and second light sources (170) which are configured to be placed against the side of the container (110) to transmit light at first and second wavelengths into the container (110), wherein the first wavelength is different from the second wavelength. The sensor (310) further includes at least one photoreceptor (160) configured to be placed against the side of the container (110) to receive light which has been transmitted into the container (110) by the light sources (170) and reflected out of the container (110). The intensity of the light received by the photoreceptor (160) for the first and second wavelengths is compared with reference characteristics to determine whether or not the drink (112) has been spiked.

Classes IPC  ?

• G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
• G01N 33/14 - Boissons

Abrégé

in vivo in vivoMycobacterium tuberculosis Mycobacterium tuberculosis (Mtb) when delivered within the nanoparticles is less than the amount of the same antimicrobial delivered alone.

Classes IPC  ?

• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 38/03 - Peptides ayant jusqu'à 20 amino-acides dans une séquence indéterminée ou partiellement déterminéeLeurs dérivés
• A61K 38/04 - Peptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminéeLeurs dérivés
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61P 31/04 - Agents antibactériens

Abrégé

Disclosed is a gas sensing apparatus which includes a gas sensor, a modulator, and a processor. A gas sensitive property affects an output signal of the gas sensor and is sensitive to a gas of interest with a sensitivity dependent on a gas sensor parameter. The modulator is configured in operation to modulate the gas sensor parameter at a modulation frequency. The processor is configured in operation to receive the output signal of the gas sensor and to identify or selectively emphasise main and/or higher harmonics of the modulation frequency in the output signal of the gas sensor for sensing of the gas of interest. The modulation has a period less than an average gas adsorption time constant of the gas sensor. A method of gas detection is also disclosed.

Classes IPC  ?

• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes

Abrégé

The present invention concerns new surface-active polyethylene glycol)-derived hydrogels that are crosslinked by using thiol-Michael addition and a crosslinker. The new concept of preparing thermally responsive hydrogels with a thin active surface layer relies on the forced emulsion formation and sedimentation from the aqueous prepolymer solution by using a crosslinker that is engineered to serve as an antisolvent for the prepolymer while at the same time exhibiting a suitable solubility profile in the sedimented hydrogel layer with respect to the supernatant aqueous phase. The solubility of the crosslinker is higher in the supernatant aqueous phase as compared to the sedimented hydrogel phase. This leads to different concentrations of crosslinker at the bottom and interfacial layers of the hydrogel, different degrees of crosslinking, as well as a higher equilibrium water concentration in the top active layer.

Classes IPC  ?

• C08J 3/075 - Gels macromoléculaires
• C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
• C07C 67/08 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques avec le groupe hydroxyle ou O-métal de composés organiques
• G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur
• C08L 71/02 - Oxydes des polyalkylènes
• C08G 65/332 - Polymères modifiés par post-traitement chimique avec des composés organiques contenant de l'oxygène contenant des groupes carboxyle, ou leurs halogénures ou esters

Abrégé

The invention concerns colostrum and, in particular, colostrum in tablet form, as well as methods to produce such tablets. A method is provided for making colostrum tablets, the method comprising: providing colostrum powder; wet granulating the colostrum powder; dry mixing the granulated colostrum powder with microcrystalline cellulose; adding a lubricant; and compressing the resultant mix.

Classes IPC  ?

• A23C 9/20 - Produits diététiques à base de lait non couverts par les groupes
• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 35/20 - LaitPetit-laitColostrum

Abrégé

The present invention provides for a method of prognosing preeclampsia in a pregnant subject wherein the method comprises measuring the level of at least three biomarkers in a sample from the subject; optionally determining at least one clinical cofactor from the subject; generating a prediction value, wherein the prediction value indicates whether the subject will develop or will not develop preeclampsia during the ongoing pregnancy; the prediction value being based on the levels of the at least three biomarkers in the sample from the subject and optionally based on the at least one clinical cofactor.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

Disclosed herein are methods for treating metabolic syndrome in a subject using a vitamin D receptor agonist. A preferred vitamin D receptor agonist for the present invention is elocalcitol.

Classes IPC  ?

• A61K 31/59 - Composés contenant le système cyclique du 9,10-séco-cyclopenta[a]hydrophénanthrène
• A61K 31/045 - Composés hydroxylés, p. ex. alcoolsLeurs sels, p. ex. alcoolates
• A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
• A61K 31/185 - AcidesLeurs anhydrides, halogénures ou sels, p. ex. acides du soufre, acides imidiques, hydrazoniques ou hydroximiques
• A61K 31/593 - Dérivés du 9,10-séco-cholestane, p. ex. cholécalciférol, vitamine D3

Abrégé

An analysis device (100, 200, 300) for analysing a liquid sample (130) for one or more analytes (141-145) is proposed, wherein the device (100, 200, 300) comprises two or more analytic regions (123, 126, 128a) and one or more non-analytic regions (112); each of the analytic regions (123, 126, 128a) is provided as a sample interaction region and/or a detection region for the one or more analytes (141-145); the two or more analytic regions (123, 126, 128a) and the one or more non-analytic regions (112) are provided in one or more substrates in one or more planes; at least one of the two or more analytic regions (123, 126, 128a) is formed by a porous material made from particles and a binder; and the two or more analytic regions (123, 126, 128a) being separated from the one or more non-analytic regions (112) by diffusion barriers (113) for fluid in the one or more analytic regions (123, 126, 128a) corresponding analysis arrangement (1000), a method of producing a corresponding analysis device, and a corresponding analysis method are also provided.

Classes IPC  ?

• G01N 30/60 - Préparation de la colonne
• G01N 30/92 - Préparation de la plaque
• G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes

Abrégé

The invention relates to novel membrane-permeable constructs and membrane-permeable constructs for use in the transport of cargo across a lipid membrane and subsequent delivery of said cargo into a cell. The cargo may be mRNA and the cell may be in vivo, such as cell of the spleen. Also provided are pharmaceutical compositions comprising the membrane- permeable constructs and use thereof in methods of raising an immune response in a subject.

Classes IPC  ?

• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61P 35/00 - Agents anticancéreux

Abrégé

Polypeptides that traverse the blood-brain-barrier (BBB) are disclosed. The peptide can serve as BBB-traversing transport vehicles for delivering active agents from the circulation into across the BBB to contact cells and tissues within the CNS and/or brain. Therefore, composition of conjugates including polypeptides that traverse the BBB, conjugated with one or more active agents are provided. The BBB-traversing peptides can be a fusion protein that includes one or more additional domains such as a targeting moiety, a linker, an active agent, a purification tag, or any combination thereof. Exemplary BBB- traversing peptides include polypeptides having an amino acid sequence RRVISRAKLAAAL (SEQ ID NO:1), or a functional variant thereof, or the amino acid sequence of CVGTNCY (SEQ ID NO:2).

Classes IPC  ?

• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• A61P 29/02 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS] sans effet anti-inflammatoire
• A61P 31/00 - Agents anti-infectieux, c.-à-d. antibiotiques, antiseptiques, chimiothérapeutiques
• A61P 35/00 - Agents anticancéreux
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• A61P 25/04 - Analgésiques centraux, p. ex. opioïdes

Abrégé

A hybrid computing system configured to estimate a derivative of a parameter-dependent physical quantity that is dependent on a first control parameter θ of a parameterised quantum evolution executed by the quantum computing system. The classical computing system determines, based on an input bounding value and phase-correction value, a subset multiset of shift-values which define an equivalent subset multiset of trial control parameter values and corresponding weighting values and summation factors such that the trial control parameter values obey a targeted probability distribution. The quantum computing system executes the parameterised quantum evolution at the trial control parameter values and measures a parameter-dependent physical quantity for each trial control parameter value. On the classical computing system, the measurement results from these measurements are combined with the weighting values and summation factors to calculate at an estimate of a phase-correction-scaled derivative of the parameter-dependent physical quantity.

Classes IPC  ?

• G06N 10/20 - Modèles d’informatique quantique, p. ex. circuits quantiques ou ordinateurs quantiques universels
• G06N 10/80 - Programmation quantique, p. ex. interfaces, langages ou boîtes à outils de développement logiciel pour la création ou la manipulation de programmes capables de fonctionner sur des ordinateurs quantiquesPlate-formes pour la simulation ou l’accès aux ordinateurs quantiques, p. ex. informatique quantique en nuage

Abrégé

A hybrid computing system comprising a quantum computing system and a classical computing system, the quantum computing system comprising a quantum system having one or more quantum devices. The hybrid computing system is configured to estimate a derivative of a parameter-dependent physical quantity that is dependent on a first control parameter 0 of a parameterised quantum evolution executed by the quantum computing system. The classical computing system determines, based on an input bounding value and phase-correction value, a subset multiset of shift-values which define an equivalent subset multiset of trial control parameter values and corresponding weighting values and summation factors such that the trial control parameter values obey a targeted probability distribution. The quantum computing system executes the parameterised quantum evolution at the trial control parameter values and measures a parameter-dependent physical quantity for each trial control parameter value. On the classical computing system, the measurement results from these measurements are combined with the weighting values and summation factors to calculate at an estimate of a phase-correction-scaled derivative of the parameter-dependent physical quantity. In this way, the derivative can be provided to a gradient-descent optimiser to optimise the control parameters of a quantum algorithm.

Classes IPC  ?

• G06N 10/60 - Algorithmes quantiques, p. ex. fondés sur l'optimisation quantique ou les transformées quantiques de Fourier ou de Hadamard

Abrégé

A method and apparatus are disclosed for assessing gas exchange of plants. The method includes receiving in a gas analyzer a plurality of test air samples from a leaf chamber corresponding respectively to first and second plant leaf samples received separately and in sequence in the leaf chamber while being exposed to light to form the first and second test air samples, the first and second test air samples being received in sequence in the gas analyzer as an integrated gas stream, and the gas analyzer analyzing the integrated gas stream as it flows therethrough. The measuring apparatus includes a leaf chamber for receiving therein a plant leaf sample to be tested, a pump communicating with the leaf chamber for supplying air thereto, and an analyzer communicating with the leaf chamber for receiving air therefrom and for analyzing the air received.

Classes IPC  ?

• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
• G01N 1/24 - Dispositifs d'aspiration

Abrégé

The present invention relates to methods for the encapsulation of bioactive entities, and formation into solid materials. The method comprises encapsulation of a bioactive entity via microfluidics and electrospinning into polymer fibres. The invention also relates to electrospun polymer fibres comprising bioactive entity-containing hydrophilic and/or gel-forming polymer microparticles embedded within fibres of at least one hydrophobic polymer. The invention also relates to a wound dressing comprising the electrospun fibres.

Classes IPC  ?

• D01D 5/00 - Formation des filaments, fils ou similaires
• A61L 15/44 - Médicaments
• D01F 1/10 - Autres agents modifiant les propriétés de ces filaments

Abrégé

The present invention relates to a method of preparing a nanoparticle comprising at least one cell- penetrating peptide (CPP) and a cargo molecule, said method comprising the steps: preparing a CPP solution comprising a CPP, a dry alcohol; and 1-50% (v/v) of an aprotic solvent; diluting the CPP solution in water to a concentration of 2 to 500 µM, and adding the cargo molecule to the CPP solution to obtain a CPP:CM mixture; whereby nanoparticles comprising CPP and cargo molecule are formed. The invention further relates to a nanoparticle obtained or obtainable by the method, as well as pharmaceutical compositions comprising such nanoparticles.

Classes IPC  ?

• A61K 9/51 - Nanocapsules
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61K 47/08 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant de l'oxygène
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés

Abrégé

The present invention is based on evidence of non-contact transfer of embryonic RNA transcripts to endometrium in an in vitro embryo-maternal cross-talk model. RNA is taken up by the endometrial cells and the expression of endogenous transcripts is altered as a result. The effect can be seen in endometrial cells treated with embryo derived extracellular vesicles (EVs) or conditioned medium derived from IVF embryos. RNA from EVs derived from human IVF embryos and conditioned culture media from the human IVF embryos have the potential to change the level of endometrial transcripts. Interestingly, only good-prognosis viable embryos, i.e., capable of producing pregnancies, induced the observed effect while non-competent, e.g., degenerated, embryos failed to initiate any changes. Hence, the capability of inducing a change in RNA transcripts can be used to determine quality of IVF embryos and in predicting pregnancy outcome.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

A method of measuring a biomechanical parameter of soft biological tissue is described. The method includes a pre-measurement process wherein an impulse applying device applies a pre-pressure to a surface of the tissue via an end portion contacting the tissue surface. While maintaining the pre-pressure, the device generates at least two impulses separated by a time interval, each impulse causing the end portion to impart to the tissue an action with certain parameters, each action inducing a response of the tissue. A value of a biomechanical parameter of the tissue is determined from each response induced. A determination is made as to whether the determined values of the biomechanical parameter are sufficiently similar to each other to indicate that the pre-pressure, the parameters of the end portion actions and the time interval are acceptable for use in a measurement process to be conducted on the surface of the tissue.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 9/00 - Instruments pour l'examen par percussionPlessimètres

Abrégé

The present invention relates generally to methods of producing products by bacterial cells. More particularly, the present invention relates to methods of producing products by bacterial cells, the methods comprising a step of irreversibly inactivating an origin of replication in the bacterial cell. The present invention also relates to modified bacterial cells, polynucleotide vectors, and uses thereof for producing products.

Classes IPC  ?

• C12N 1/20 - BactériesLeurs milieux de culture
• C12N 1/36 - Adaptation ou atténuation de cellules
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora

Abrégé

Disclosed are compositions, compounds, and methods relating to peptides that can target and home to cancer, tumors, and extracellular matrix. This is based on the discovery of peptides that can specifically bind to fibronectin extra domain B (FN-EDB), tenascin-C C domain (TNC-C), or both.

Classes IPC  ?

• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• A61P 35/00 - Agents anticancéreux

Abrégé

This invention relates to a vaccine comprising live attenuated Zika virus comprising a partly codon deoptimized viral genome, a Zika virus comprising a partly codon deoptimized viral genome, as well as their use in methods of treatment and prevention of viral infection. is deoptimized along the nonstructural ZIKV coding region. In some embodiments, the non-structural region of the viral genome is codon deoptimized, and preferably one or more of the genes NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 are codon deoptimized.

Classes IPC  ?

• A61K 39/12 - Antigènes viraux
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present invention provides for a method of prognosing preeclampsia in a pregnant subject wherein the method comprises measuring the level of at least three biomarkers in a sample from the subject; optionally determining at least one clinical cofactor from the subject; generating a prediction value, wherein the prediction value indicates whether the subject will develop or will not develop preeclampsia during the ongoing pregnancy; the prediction value being based on the levels of the at least three biomarkers in the sample from the subject and optionally based on the at least one clinical cofactor.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

- 24 - Abstract Method and apparatus for assessing gas exchange of plants A method is disclosed for assessing gas exchange of plants, comprising 5 receiving in a gas analyzer a plurality of test air samples from a leaf chamber corresponding respectively to first and second plant leaf samples received separately and in sequence in the leaf chamber while being exposed to light to form the first and second test air samples, the first and second test air samples being received in sequence in the gas analyzer as an integrated gas stream, and the gas 10 analyzer analysing the integrated gas stream as it flows therethrough. Measuring apparatus for assessing gas exchange of plants is also disclosed, comprising a leaf chamber for receiving therein a plant leaf sample to be tested, a pump communicating with the leaf chamber for supplying air thereto, an analyzer communicating with the leaf chamber for receiving air therefrom and for analysing 15 the air received, wherein the pump is configured to be filled with a single charge of air and to supply plural doses of air from that single charge each for sequentially testing a respective plant leaf sample of a plurality of plant leaf samples. 20 25 30 35

Classes IPC  ?

• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes

Abrégé

Provided herein are polypeptides, polynucleotides, expression vectors, infectious clones, virus particles and immunogenic compositions of recombinant alphaviruses which can be used as vaccines. Also provided are methods for eliciting an immune response against alphavirus infection using the immunogenic composition comprising the alphavirus mutants described herein.

Classes IPC  ?

• C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61K 39/12 - Antigènes viraux
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present invention is based on evidence of non-contact transfer of embryonic RNA transcripts to endometrium in an in vitro embryo-maternal cross-talk model. RNA is taken up by the endometrial cells and the expression of endogenous transcripts is altered as a result. The effect can be seen in endometrial cells treated with embryo derived extracellular vesicles (EVs) or conditioned medium derived from IVF embryos. RNA from EVs derived from human IVF embryos and conditioned culture media from the human IVF embryos have the potential to change the level of endometrial transcripts. Interestingly, only good- prognosis viable embryos, i.e., capable of producing pregnancies, induced the observed effect while non- competent, e.g., degenerated, embryos failed to initiate any changes. Hence, the capability of inducing a change in RNA transcripts can be used to determine quality of IVF embryos and in predicting pregnancy outcome.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
• A01K 67/00 - Élevage ou obtention d'animaux, non prévus ailleursNouvelles races ou races modifiées d'animaux

Abrégé

A method of preparing an alcogel for use as a source of fuel includes the steps of hydrolysing at least one tetraalkoxysilane with water in the presence of a solvent and catalyst, wherein the solvent includes at least one alcohol, and wherein the molar ratio (R) of water to alkoxide is greater than 4. The alcogel can then be stored in a hermetically sealed container in order to minimise evaporation of the alcohol, and used as a source of fuel, for example for use when camping.

Classes IPC  ?

• C10L 7/04 - Combustibles produits par solidification de combustibles fluides combustibles liquides alcool

Abrégé

The present invention provides for a method of prognosing or diagnosing preeclampsia in a subject wherein the method comprises measuring the level of at least four biomarkers in a blood sample from the subject; optionally determining at least one clinical cofactor from the subject; generating a prediction value, wherein the prediction value indicates whether the subject will develop or will not develop preeclampsia or has preeclampsia; the prediction value being based on the levels of the at least four biomarkers in the blood sample from the subject and optionally based on the at least one clinical cofactor.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A method of noninvasively measuring a biomechanical parameter of soft biological tissue, using an impulse applying device comprising a movable testing body having an end portion to be placed in contact with a surface of the tissue, the method comprising a pre-measurement process which comprises: the impulse applying device applying a pre-pressure to the surface of the tissue via the end portion in contact with the surface of the tissue; whilst maintaining said pre-pressure, the impulse applying device generating at least two impulses separated by a time interval, each impulse causing the end portion to impart to the tissue an action with certain parameters, and each of the end portion actions inducing a response of the tissue; determining a value of a biomechanical parameter of the tissue from the response induced by each end portion action; and determining if the values of the biomechanical parameter determined from the response induced by each end portion action are sufficiently similar to each other to indicate that the pre-pressure, the parameters of the end portion actions and the time interval are acceptable for a measurement process to be conducted on the surface of the tissue using the same pre-pressure, a plurality of end portion actions with the same parameters and the same time interval.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 9/00 - Instruments pour l'examen par percussionPlessimètres

Abrégé

Disclosed are compositions, compounds, and methods relating to peptides that can target and home to cancer, tumors, and extracellular matrix. This is based on the discovery of peptides that can specifically bind to fibronectin extra domain B (FN-EDB), tenascin-C C domain (TNC-C), or both.

Classes IPC  ?

• A61K 38/04 - Peptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminéeLeurs dérivés
• A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C07K 7/00 - Peptides ayant de 5 à 20 amino-acides dans une séquence entièrement déterminéeLeurs dérivés
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides

Abrégé

Disclosed are compositions, compounds, and methods relating to peptides that can target and home to cancer, tumors, and extracellular matrix. This is based on the discovery of peptides that can specifically bind to fibronectin extra domain B (FN-EDB), tenascin-C C domain (TNC-C), or both.

Classes IPC  ?

• C07K 7/00 - Peptides ayant de 5 à 20 amino-acides dans une séquence entièrement déterminéeLeurs dérivés
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• A61K 38/04 - Peptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminéeLeurs dérivés
• A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés

Abrégé

The present invention provides for a membrane-permeable construct for transport of cargo across a lipid membrane and subsequent delivery of cargo into cells, wherein the construct comprises a cell penetrating amino acid sequence and a fatty acid chain attached to the N terminus thereof, wherein the cell penetrating amino acid sequence comprises the sequence of SEQ ID NO: 1, or comprises a modified sequence of SEQ ID NO: 1, wherein the cell penetrating amino acid sequence comprises two or more histidine residues by substitution to its N-terminal part and/or addition to its N-terminus, and wherein the cell penetrating amino acid sequence is optionally chemically modified at the C terminus.

Classes IPC  ?

• A61K 47/62 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant une protéine, un peptide ou un acide polyaminé
• C12N 15/87 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation

Abrégé

A method for producing a carbon nanomaterial for use as a catalyst, including the steps of: (a) providing a precursor which is a source of lignin, (b) heating the precursor to an activation temperature from 700°C to 800°C in the presence of an alkali solution in order to produce an activated precursor, and (c) reacting the activated precursor with a source of nitrogen atoms in order to dope the activated precursor with nitrogen atoms, wherein the precursor is heated in step (b) to the activation temperature at a rate of at least 500°C per minute.

Classes IPC  ?

• H01M 4/88 - Procédés de fabrication
• H01M 4/90 - Emploi de matériau catalytique spécifié

Abrégé

This invention relates to a vaccine comprising live attenuated Zika virus comprising a partly codon deoptimized viral genome, a Zika virus comprising a partly codon deoptimized viral genome, as well as their use in methods of treatment and prevention of viral infection. is deoptimized along the nonstructural ZIKV coding region. In some embodiments, the non-structural region of the viral genome is codon deoptimized, and preferably one or more of the genes NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 are codon deoptimized.

Classes IPC  ?

• A61K 39/12 - Antigènes viraux
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification

Abrégé

The present invention relates to novel catalysts, methods of making said catalysts, associated chemical intermediates and uses of said catalysts.

Classes IPC  ?

• H01M 4/90 - Emploi de matériau catalytique spécifié
• H01M 4/96 - Électrodes à base de carbone
• B01J 37/08 - Traitement thermique
• B01J 23/70 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe du cuivre ou des métaux du groupe du fer
• B01J 21/18 - Carbone

Abrégé

The present invention generally relates to polypeptides, polynucleotides, expression vectors, infectious clones, virus particles and immunogenic compositions of recombinant alphaviruses which can be used as vaccines. The present disclosure also relates to methods for eliciting an immune response against alphavirus infection using the immunogenic composition comprising the alphavirus mutants described herein.

Classes IPC  ?

• C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61K 39/12 - Antigènes viraux
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

endoexog2d,95nn = 80.6 kg/mol) was determined for the polymethacrylate with Ac-substitute.

Classes IPC  ?

• C12P 41/00 - Procédés utilisant des enzymes ou des micro-organismes pour la séparation d'isomères optiques à partir d'un mélange racémique
• C07D 493/04 - Systèmes condensés en ortho
• C08F 124/00 - Homopolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un hétérocycle contenant de l'oxygène
• C12P 7/62 - Esters d’acides carboxyliques
• C12P 17/18 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, p. ex. rifamycine

Abrégé

The present invention generally relates to a recombinant polypeptides comprising an amino acid sequence, or a variant thereof derived from the Chikungunya virus non-structural polyprotein (SEQ ID NO: 1 ) comprising one or more mutations selected from the group consisting of (a) a mutation at a position equivalent to amino acid position 532 of SEQ ID NO: 1, and (b) a mutation at a position equivalent at amino acid position 1050 of SEQ ID NO: 1. Also claimed are polynucleotides, expression vectors, infectious clones, virus particles and immunogenic compositions of recombinant alphaviruses comprising said polypeptides. The present disclosure also relates to methods for eliciting an immune response against alphavirus infection using the immunogenic compositions of alphaviruses mutants described herein.

Classes IPC  ?

• C07K 14/18 - Togaviridae, p. ex. flavivirus, virus de la peste, virus de la fièvre jaune, virus de l'hépatite C, virus de l'encéphalite japonaise
• A61K 39/12 - Antigènes viraux
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

The present invention relates to a method for forming a capacitor having carbon or metal electrodes and an electrolyte which is also a source of electropolymerisable anions. Applying a sufficiently positive voltage, a thin dielectric layer forms at the positive electrode, enabling the use of cell voltages higher than 3.5 V. The construction and characteristics of capacitors with 5, 6.3, and 10 V of cell voltages, having reduced graphene oxide electrodes and an ionic liquid electrolyte, are shown. Further, a method of forming a capacitor, including the steps of: (a) providing a first electrode; (b) providing a first electrolyte including an anionic compound, wherein said compound includes at least one cyano group or at least one nitrile group; (c) electropolymerising said anionic compound in order to form a dielectric layer on at least part of the first electrode; (d) forming a capacitor including the electrode of step (c), a second electrode and a second electrolyte, which is the same or different to the first electrolyte, is claimed. In a further aspect of the invention, there is provided an electronic device including a capacitor, a transistor or an electrode produced by means of a method as defined above. It is believed that a number of dielectric compounds produced by the method as defined above are new compounds not previously isolated. Accordingly, polytetracyanoborate, polycyani, or polytricyanomethanide.

Classes IPC  ?

• H01G 9/00 - Condensateurs électrolytiques, redresseurs électrolytiques, détecteurs électrolytiques, dispositifs de commutation électrolytiques, dispositifs électrolytiques photosensibles ou sensibles à la températureProcédés pour leur fabrication
• C25D 9/02 - Revêtement électrolytique autrement qu'avec des métaux avec des matières organiques
• H01G 9/028 - Électrolytes organiques semi-conducteurs, p. ex. TCNQ
• H01G 9/15 - Condensateurs à électrolyte solide
• H01L 21/28 - Fabrication des électrodes sur les corps semi-conducteurs par emploi de procédés ou d'appareils non couverts par les groupes
• H01G 9/042 - Électrodes caractérisées par le matériau
• H01G 9/048 - Électrodes caractérisées par leur structure
• H01G 11/86 - Procédés de fabrication de condensateurs hybrides ou EDL ou de leurs composants spécialement adaptés pour les électrodes
• H01G 11/32 - Électrodes caractérisées par leur matériau à base de carbone
• H01G 11/26 - Électrodes caractérisées par leur structure, p. ex. multicouches, selon la porosité ou les caractéristiques de surface
• H01G 11/56 - Électrolytes solides, p. ex. gelsAdditifs pour ceux-ci
• H01L 29/51 - Matériaux isolants associés à ces électrodes
• C08G 73/02 - Polyamines

Abrégé

Electrodes, separators, half-cells, and full cells of electrical energy storage devices are made with electrospinning and isostatic compression. The electrical energy storage device may include electrochemical double layer capacitors (EDLCs, also known as “supercapacitors”), hybrid supercapacitors (“HSCs”), Li-ion capacitors and electrochemical storage devices, Na-ion capacitors and electrochemical storage devices, polymer electrolyte fuel cells, and still other capacitors and electrochemical storage cells.

Classes IPC  ?

• D01D 5/00 - Formation des filaments, fils ou similaires
• H01M 2/14 - Séparateurs; Membranes; Diaphragmes; Eléments d'espacement
• H01M 2/16 - Séparateurs; Membranes; Diaphragmes; Eléments d'espacement caractérisés par le matériau
• H01M 4/88 - Procédés de fabrication
• H01M 4/04 - Procédés de fabrication en général
• H01M 4/92 - Métaux du groupe du platine
• H01M 8/1081 - Matériaux d’électrolyte polymère caractérisés par le procédé de fabrication à partir de solutions, de dispersions ou de suspensions de polymères uniquement
• H01M 8/1086 - Post-traitement de la membrane autrement que par polymérisation
• H01M 8/1004 - Éléments à combustible avec électrolytes solides caractérisés par les ensembles membrane-électrodes [MEA]
• H01G 11/86 - Procédés de fabrication de condensateurs hybrides ou EDL ou de leurs composants spécialement adaptés pour les électrodes
• H01G 11/04 - Condensateurs hybrides
• H01G 11/38 - Pâtes ou mélanges de carboneLiants ou additifs
• H01G 11/46 - Oxydes métalliques
• H01G 11/52 - Séparateurs
• H01G 11/70 - Collecteurs de courant caractérisés par leur structure
• H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
• H01M 8/1018 - Matériaux d’électrolyte polymère
• H01M 10/052 - Accumulateurs au lithium

Abrégé

The application relates to flexible ionic electroactive polymer (IEAP) laminates also known as ionic capacitive laminates (ICLs) particularly used for actuators, sensors or capacitors. More specifically, the invention relates to ICLs capable of fabrication on an industrial scale. An ionic electroactive polymer laminate suitable for use as an actuator is described, comprising opposing planar electrodes separated by an electrode-separating layer, wherein the electrode separating layer comprises a flexible porous reinforcing web suitable for supporting the laminate during fabrication, the electrode- separating layer further including an ion permeable polymer membrane within the pores of the reinforcing web. A method of producing an ionic electroactive polymer laminate suitable for use as an actuator is also described, comprising the steps of producing a planar electrode-separator by supporting a flexible, porous reinforcing web so that it is taught, impregnating the reinforcing web with a membrane solution that includes a polymer suitable for forming an ion permeable membrane, a pore- forming liquid and a solvent, evaporating the solvent to form an ion permeable membrane within the structure of the reinforcing web, the method further including the steps of coating each side of the planar electrode-separator with an electrode solution comprising material suitable for forming electrodes and an electrode solvent, evaporating the electrode solvent to form planar electrodes separated by the electrode-separator.

Classes IPC  ?

• F03G 7/00 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs

Produits et services

Electronic downloadable publications; Electronic notice boards; Electronic publications, downloadable; Downloadable newspapers and magazines; Reflecting strips for wear, reflecting discs for wear; Reflective safety vests; Eyewear. Paper; Paperboard; Cardboard boxes; Stickers [stationery]; Notepaper; Writing paper; Printed matter, including newspapers, magazines, scrapbooks, almanacs, pamplets, photographs, information materials, calendars, maps, calatogues, prospectuses, books, notebooks, postcards, labels (not of textile), postage stamps, stationery; Office requisites; Teaching materials (except apparatus); Packaging and packaging materials of paper and cardboard; Plastic film for wrapping; Bags [envelopes, pouches] of paper or plastics, for packaging; Luggage tags of paper; Sports trading cards. Casual bags; Sport bags; Backpacks; Suitcases; Baggage tags; Umbrellas. Clothing, sports clothing, tee-shirts, headgear, sports headgear, headbands; Footwear not for sports; Sports shoes. Beers; Mineral and aerated waters and other non-alcoholic beverages; Sports drinks. Business management of sporting facilities [for others]; Advice relating to the business management of sport clubs; Business management in the field of sports; Promoting the goods and services of others by arranging for sponsors to affiliate their goods and services with sports competitions; Promoting the goods and services of others by arranging for sponsors to affiliate their goods and services with sporting activities; Advertising, including promotion of products and services of third parties through sponsoring arrangements and licence agreements relating to international sports' events. Organisation of sports competitions; Production of sporting events; Sport camp services; Sports-park services; Rental of sports equipment, except vehicles; Games equipment rental; Rental of sports grounds; Providing sports facilities; Rental of tennis courts; Health club services [health and fitness training]; Coaching [training]; Sports training; Personal trainer services [fitness training]; Officiating at sports contests; Physical education; Entertainment; Arranging of competitions for education or entertainment; Tutoring; Entertainment provided during intervals of sporting events; Arranging and conducting of courses, seminars and workshops.

Abrégé

The present invention relates to a method for forming a capacitor having carbon or metal electrodes and an electrolyte which is also a source of electropolymerisable anions. Applying a sufficiently positive voltage, a thin dielectric layer forms at the positive electrode, enabling the use of cell voltages higher than 3.5 V. The construction and characteristics of capacitors with 5, 6.3, and 10 V of cell voltages, having reduced graphene oxide electrodes and an ionic liquid electrolyte, are shown. Further, a method of forming a capacitor, including the steps of: (a) providing a first electrode; (b) providing a first electrolyte including an anionic compound, wherein said compound includes at least one cyano group or at least one nitrile group; (c) electropolymerising said anionic compound in order to form a dielectric layer on at least part of the first electrode; (d) forming a capacitor including the electrode of step (c), a second electrode and a second electrolyte, which is the same or different to the first electrolyte, is claimed. In a further aspect of the invention, there is provided an electronic device including a capacitor, a transistor or an electrode produced by means of a method as defined above. It is believed that a number of dielectric compounds produced by the method as defined above are new compounds not previously isolated. Accordingly, polytetracyanoborate, polycyani, or polytricyanomethanide.

Classes IPC  ?

• H01G 4/33 - Condensateurs à film mince ou à film épais
• H01G 9/028 - Électrolytes organiques semi-conducteurs, p. ex. TCNQ
• H01G 9/035 - Électrolytes liquides, p. ex. matériaux d'imprégnation
• H01G 11/36 - Nanostructures, p. ex. nanofibres, nanotubes ou fullerènes
• H01G 11/56 - Électrolytes solides, p. ex. gelsAdditifs pour ceux-ci
• H01G 11/86 - Procédés de fabrication de condensateurs hybrides ou EDL ou de leurs composants spécialement adaptés pour les électrodes
• H01G 4/18 - Diélectriques organiques en matériau synthétique, p. ex. en dérivés de la cellulose

Abrégé

A method for preparing thin double-structured composite corrosion resistant and/or passivating coatings that consist of a thin metal oxide-hydroxide subcoating prepared by anodizing the metal substrate materials near-surface part and then provided with an atomic layer deposition (ALD) topmost nanocoating, of e.g. oxide, nitride, carbonate, carbide etc. or their mixes or laminates, or laminates with ceramic and metallic layers, or laminates with inorganic or organic polymers and ceramic layers.

Classes IPC  ?

• C23C 16/00 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD]
• C25D 5/48 - Post-traitement des surfaces revêtues de métaux par voie électrolytique
• C25D 11/02 - Anodisation
• C25D 11/06 - Anodisation de l'aluminium ou de ses alliages caractérisée par les électrolytes utilisés
• C25D 11/18 - Post-traitement, p. ex. bouchage des pores
• C23C 28/04 - Revêtements uniquement de matériaux inorganiques non métalliques
• C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction
• C23C 16/48 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement par irradiation, p. ex. par photolyse, radiolyse ou rayonnement corpusculaire
• C23C 16/50 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement au moyen de décharges électriques

Abrégé

Lactobacillus fermentum ME-3 strain DSM 14241 for use in preventing, alleviating the symptoms of or treating, alone or as an adjuvant component, a metabolic syndrome related disorder selected from prediabetes, type 2 diabetes and cardiovascular disease. The effect may be achieved by simultaneously: decreasing the level of glycated haemoglobin HbA1c, decreasing or preventing low-grade inflammation on a cellular level and increasing the level of adiponectin.

Classes IPC  ?

• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• A61K 35/747 - Lactobacilles, p. ex. L. acidophilus ou L. brevis
• A23G 1/42 - Produits à base de cacao, p. ex. chocolatLeurs succédanés caractérisés par la composition contenant des micro-organismes ou des enzymesProduits à base de cacao, p. ex. chocolatLeurs succédanés caractérisés par la composition contenant des agents paramédicaux ou diététiques, p. ex. des vitamines

Abrégé

A method and device for monitoring a treatment of posture of different body parts in which a local mechanotherapeutic stimulus is applied to a subject (e.g. a human or animal). The device comprises an elastic material 1 which is to be worn over the part of the body, a pressure regulating support 4, a pressure applicator 7 and a pressure sensor 8. The support 4 is fixed to the elastic material 1 and passes over a region where mechanotherapeutic stimulus is to be applied and allows for tension in the support to be varied and to act on a convex rear face of the pressure applicator 7. The sensor 8 is rigidly attached to the pressure applicator 7 and they are together received in a pocket. The sensor senses pressure and hence a stimulus applied to the part as a result of the tension in the support, the sensor being configured to output a signal indicative of the pressure applied, providing the opportunity to change the stimulus to within a given range based on the feedback from the sensor.

Classes IPC  ?

• A61F 5/01 - Dispositifs orthopédiques, p. ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61F 5/32 - Coussinets de compression réglables

Abrégé

There is provided inter alia a compound of formula (I), Q-L-P wherein Q is a moiety that binds to the ATP -binding site of a Pim kinase; L is an organic tether that connects Q to P and permits simultaneous binding of Q and P to a Pim kinase; P is a moiety that binds to the protein binding domain of Pim kinase; and wherein the compound of formula (I) is optionally labelled with a fluorophore.

Classes IPC  ?

• A61K 38/00 - Préparations médicinales contenant des peptides
• C07K 19/00 - Peptides hybrides
• C07D 235/10 - Radicaux substitués par des atomes d'halogènes ou des radicaux nitro
• C07D 239/22 - Composés hétérocycliques contenant des cycles diazine-1, 3 ou diazine-1, 3 hydrogéné non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des hétéro-atomes liés directement aux atomes de carbone du cycle

Abrégé

The invention provides a composition comprising Lactobacillus fermentum ME-3 strain DSM 14241 for use in preventing, alleviating the symptoms of or treating, alone or as an adjuvant component,a metabolic syndrome related disorder selected from prediabetes, type 2 diabetes and cardiovascular disease. The effect may be achieved by simultaneously:decreasing the level of glycated haemoglobin HbA1c, decreasing or preventing low-grade inflammation on a cellular level and increasing the level of adiponectin.

Classes IPC  ?

• A61K 35/74 - Bactéries
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A61P 39/06 - Antiradicaux libres ou antioxydants

Abrégé

A method for preparing thin double-structured composite corrosion resistant and/or passivating coatings that consist of a thin metal oxide-hydroxide subcoating prepared by anodizing the metal substrate materials near-surface part and then provided with an atomic layer deposition (ALD) topmost nanocoating, of e.g. oxide, nitride, carbonate, carbide etc. or their mixes or laminates, or laminates with ceramic and metallic layers, or laminates with inorganic or organic polymers and ceramic layers.

Classes IPC  ?

• C25D 11/18 - Post-traitement, p. ex. bouchage des pores
• C23C 28/04 - Revêtements uniquement de matériaux inorganiques non métalliques

Abrégé

The invention provides a composition comprising Lactobacillus fermentum ME-3 strain DSM 14241 for use in preventing, alleviating the symptoms of or treating, alone or as an adjuvant component,a metabolic syndrome related disorder selected from prediabetes, type 2 diabetes and cardiovascular disease. The effect may be achieved by simultaneously:decreasing the level of glycated haemoglobin HbA1c, decreasing or preventing low-grade inflammation on a cellular level and increasing the level of adiponectin.

Classes IPC  ?

• A61K 35/74 - Bactéries
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
• A61P 39/06 - Antiradicaux libres ou antioxydants

Abrégé

The present invention is related to a method for detecting neoplastic cells originating from lung tissue with DNA and RNA-based biomarkers whereas the method comprising steps of isolating DNA or RNA from lung tissue or remote body fluids, detecting the methylation state of DNA of one or more, and/or detecting the expression levels of one or more micro-RNAs, thereafter determining the presence of neoplastic cells by comparing the methylation level and/or expression level of the genes with the levels of same genes in non-neoplastic cells, whereas if the methylation or expression level in the cell differs from the normal methylation or expression level in the cell said cell is considered neoplastic. There have been identified genes with altered methylation and microRNAs with aberrant expression in NSCLC.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The present invention involves detection of differential expression of specific microRNAs (miRNAs) in certain biological/pathological conditions, and functional applications of miR-511, miR-193b,miR-99b and other listed miRNAs as markers and targets in cancer and immune system related diseases. The microRNAs are used as an expression modulation targets for influencing proliferative properties of a cell and/or immune functions of an organism.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The present invention relates to a method of spraying the analyte or the effluent comprising the analyte from ionisation source into mass spectrometer whereas into the spray of the effluent is directed additional inner spray of the nebulising gas for breaking the spray of the effluent and for reducing the size of the effluent droplets. For implementing of said method is proposed a injector capillary system where into the external capillary (A) of the outer nebulizer gas is placed the capillary (B) of the analyte or effluent comprising the analyte into which is respectively placed additional third inner capillary (C) or the bundle of inner capillaries of the nebulizer gas where through capillary (C) the nebulising gas is directed into the spray of the effluent.

Classes IPC  ?

• H01J 49/16 - Sources d'ionsCanons à ions utilisant une ionisation de surface, p. ex. émission thermo-ionique ou photo-électrique

Abrégé

The present application describes a sensor device used, for example, in robotics, biotechnology, biomedicine and medicine, whereas the sensor device is manufactured from carbon-ionic liquid-polymer composite, comprising at least two separator layers, which are made from carbon-ionic liquid-polymer composite material and comprises at least two electrode layers manufactured of carbon film and separated by a layer manufactured as porous polymer membrane comprising an ionic liquid not having electronic conductivity. At the same time the sensor device acts as actuator, which allows immediate feedback of the actuator curvature, its velocity and change of direction of movement.

Classes IPC  ?

• F03G 7/00 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs
• H02N 11/00 - Générateurs ou moteurs non prévus ailleursMouvements dits perpétuels obtenus par des moyens électriques ou magnétiques

Abrégé

The invention concerns novel molecular complexes with photoluminescent probes whose specific association with purine-binding proteins leads to increased emission of long lifetime luminescence, and the application of the probes for monitoring activity of protein kinases (PKs) and other purine-binding proteins, screening of compounds as inhibitors of PKs and characterization of inhibitors targeted to the kinase, and methods of manufacturing of such probes. The invention concerns also the use of the improved method for monitoring activity of protein kinases in living cells, characterization of inhibitors of protein kinases, analysis of protein kinase-based disease biomarkers and other tasks of biological and medical importance.

Classes IPC  ?

• C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
• G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
• G01N 33/573 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour enzymes ou isoenzymes
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
• C07D 233/00 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles
• C07D 333/00 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant un atome de soufre comme unique hétéro-atome du cycle
• C07D 473/00 - Composés hétérocycliques contenant des systèmes cycliques purine

Abrégé

The present invention prescribes a new sol-gel method of preparing and formation of the metal oxide microtubes. According to the method firstly is prepared the precursor sol from metal oxides or mixtures of metal oxides and alkoxides, thereafter from the precursor sol are extruded the fibres, which are gelatinised afterwards until the inner sol which is less viscous of fibres is converted to thinner wall until alcohol from the precursor is left trough walls. The metal oxide microtubes are applicable as to conduct liquids or gasses, as ionic conductors, as catalyst carriers and as light emitters.

Classes IPC  ?

• C04B 35/622 - Procédés de mise en formeTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques
• D01D 5/24 - Formation des filaments, fils ou similaires à structure creuseEnsembles de filage à cet effet
• D01F 9/10 - Filaments, ou similaires, faits par l’homme, formés d’autres substancesLeur fabricationAppareils spécialement adaptés à la fabrication de filaments de carbone de matière inorganique par décomposition de substances organiques

Abrégé

The present invention concerns nano colloidal water-sol of SnO2, and its use in the preparation of microspheres, micro and nano containers or solid and liquid filled microcapsules. According to the method firstly the stannic oxide is mixed with alcohol and the obtained mixture is poured quickly into the water. The resulting precipitate is transformed into homogeneous liquid whereas the alcohol is removed during transforming process. The aqueous solution is purified with alcohol and concentrated in vacuum at a temperature of 70-85 °C until the water solution becomes viscous syrop-like emulsion of the precursor.

Classes IPC  ?

• C01G 19/02 - Oxydes

Abrégé

A layered actuator (10) comprising at least two electrode layers (2,4) and an electronically nonconductive membrane (3) in between, where at least one electrode layer (2;4) contains carbide-derived carbon, a polymer material and an ionic liquid. The layered actuator bends due to relocation of the membrane ions when direct current is applied to the electrodes.

Classes IPC  ?

• F03G 7/00 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs

Abrégé

The present invention is related to the method and device for measuring the chemical and biological analyte or viscosity and surface tension of the liquid. The device is comprised of a tuning fork type quartz crystal resonator having an associated resonant frequency and the sensing part attached to at least one prong of the resonator. The sensing part is made from low density and high surface area material, e.g. carbon nanotube fibre. Method comprises the immersing of only the sensing part of the device into the liquid, excitation of the sensor with electric field and registration of the changes in resonant frequency due to changes in mass of the sensing part or due to changes in viscosity and surface tension of the liquid.

Classes IPC  ?

• G01N 27/00 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques
• G01N 29/02 - Analyse de fluides
• G01N 29/036 - Analyse de fluides en mesurant la fréquence ou la résonance des ondes acoustiques

Abrégé

The present invention finds application in the field of medicine and, in particular, to new compounds particularly active in inhibiting Rac1 member of the Rho family. Pharmaceutical preparations containing them useful for the treatment and/or prevention of heart failure are disclosed as well.

Classes IPC  ?

• C07D 239/47 - Un atome d'azote et un atome d'oxygène ou de soufre, p. ex. cytosine
• C07D 239/48 - Deux atomes d'azote
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61P 9/04 - Agents inotropes, c.-à-d. stimulants de la contraction cardiaqueMédicaments pour le traitement de l'insuffisance cardiaque

Abrégé

Method of preparation of surface coating of variable transmittance and an electro-optical layered appliance including the same comprises dispersing of liquid crystal microdroplets in hydrolyzable and polymerizable precursors and applying obtained mixture on a surface by spraying. Applying the material to the surface by spraying is intrinsically related to the synthesis processes because the properties of the surrounding environment (i.e. content of water and acidity, UV radiation) and the chemical reactions that take place during spraying have considerable influence on the properties (i.e. driving voltage, thickness of obtained layer). Obtained layered appliance comprises of a matrix material with dispersed microdroplets of liquid crystal obtained by the described method, electrically conductive transparent electrodes with contacts, a dielectric material, substrate and covering layers.

Classes IPC  ?

• C09K 19/52 - Substances formant des cristaux liquides caractérisées par des constituants qui ne sont pas des cristaux liquides, p. ex. additifs
• C09K 19/54 - Additifs n'ayant pas de mésophase spécifique
• G02F 1/133 - Dispositions relatives à la structureExcitation de cellules à cristaux liquidesDispositions relatives aux circuits
• G02F 1/1333 - Dispositions relatives à la structure
• G02F 1/1334 - Dispositions relatives à la structure basées sur des cristaux liquides dispersés dans un polymère, p. ex. cristaux liquides micro-encapsulés
• G02F 1/1343 - Électrodes
• G02F 1/139 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des cristaux liquides, p. ex. cellules d'affichage individuelles à cristaux liquides caractérisés par l'effet électro-optique ou magnéto-optique, p. ex. transition de phase induite par un champ, effet d'orientation, interaction entre milieu récepteur et matière additive ou diffusion dynamique basés sur des effets d'orientation où les cristaux liquides restent transparents
• C09D 183/04 - Polysiloxanes
• B05D 1/02 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces réalisés par pulvérisation
• B05D 1/34 - Application simultanée de liquides ou d'autres matériaux fluides, différents
• C09D 4/00 - Compositions de revêtement, p. ex. peintures, vernis ou vernis-laques, à base de composés non macromoléculaires organiques ayant au moins une liaison non saturée carbone-carbone polymérisable

Abrégé

A vaccine for treating melanoma, comprising at least one melanoma antigen and a viral-like particle comprising potato virus A coat protein. Use of vaccine for treating melanoma, including protein and DNA vaccines, based on potato virus A coat protein.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/12 - Antigènes viraux
• C07K 14/08 - Virus à ARN
• C07K 19/00 - Peptides hybrides

Abrégé

Actuator comprises at least one layer, composed of nanoporous carbide derived carbon, and containing an electrolyte, such as ionic liquid. The actuator extends linearly when voltage is applied to the actuator. Nanoporous carbide derived carbon layer preferably contains 80 to 100 volume percent of a material having an average pore size is less than 1 nanometer and at least 50 per cent of the total pores volume is from the pores with the size less than 1.1 nanometers. Actuator may comprise two layers of nanoporous materials, separated by membrane of polymer material.

Classes IPC  ?

• H02N 11/00 - Générateurs ou moteurs non prévus ailleursMouvements dits perpétuels obtenus par des moyens électriques ou magnétiques
• F03G 7/00 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs

Abrégé

The present invention provides a method and a kit for determining the human with genetic predisposition to increased consumption of carbohydrates and to develop metabolic, psychiatric or neurological disease or disorder, or obesity. The invention further pertains to the detection of a human's ADRA2A genotype, and if there will be detected the homozygous nucleotide G at the position C-1291 of the ADRA2A gene, then the named human has a predisposition to increased consumption of carbohydrates and to develop metabolic, psychiatric or neurological diseases or disorders or obesity, and there is a need to decrease the intake of carbohydrates.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

In the current invention a method for the preparation of an oxide material was described that involves bringing the sol onto the substrate, the gelation of the solution and thermal treatment of the gel. Alkoxides are used as precursor mterials for the sol preparation and substrate free structures are employed for the manufacturing of the oxide material. A gel film with thickness ranging from 5 nm to 1 μm is created onto the sol layer. The gelled film is separated into pieces by self organizing and the gelled part is disconnected from the substrate. Substrate free tubular structures with diameters ranging from 0.01-100 μm are formed of the gel film which are then heated at temperature range of 200-1600 C during a period of 5 minutes to 10 hours. The manufactured oxide materials are employed as catalysts, gas sensors, stationary phases of chromatographic columns, composite materials, thermal isolation materials and micro- or nano electronic mechanical systems (MEMS or NEMS) components.

Classes IPC  ?

• C01B 13/32 - Méthodes de préparation des oxydes ou hydroxydes en général par oxydation ou hydrolyse d'éléments ou de composés à l'état liquide ou solide
• C01G 23/053 - Obtention par voie humide, p. ex. par hydrolyse de sels de titane
• C01G 25/02 - Oxydes
• C01G 27/02 - Oxydes

Abrégé

A device that can be attached to a fin of a suf board or similar water craft. The device contains an opening (13) for receiving the fin (3). The device is made of elastic material and the area of the device is at least 1.5 times larger than the area of the fin of the surfboard or similar water craft. In one embodiment, the area of the device is 1.5 to 5 times larger that the area of the fin. In another embodiment, the area of the device is about 3 times larger than the area of the fin. The device may be equipped with clamping means for securely fixing the device to the fin.

Classes IPC  ?

• B63B 35/79 - Planches de glisse, p.ex. planches à voile 

Abrégé

The invention relates to a method for introducing changes into a eukaryotic genome in vivo wherein the HPV genome, which comprises HPV replication origin sequence, is used together with HPV early proteins in order to achieve DNA replication in vivo. There is also disclosed a kit for in vivo amplification, excision, translocation and/or inversion of a DNA sequence, which comprises a vector carrying HPV genome or a part of HPV genome including HPV replication origin sequence, and expression vector or vectors encoding HPV early proteins.

Classes IPC  ?

• C07K 14/025 - Papovaviridae, p. ex. virus du papillome, virus du polyome, SV40, virus BK, virus JC

Abrégé

A shape changing manipulator comprising a plurality of elements at least partly made of a bending electroactive polymer material, whereby these elements comprise integrated sensing means so as to form self-sensing actuators.

Classes IPC  ?

• B25J 9/10 - Manipulateurs à commande programmée caractérisés par des moyens pour régler la position des éléments manipulateurs

Abrégé

This invention relates to fluorescent probes for identification of compounds binding to protein kinases, for measurement of the affinity of inhibitors of protein kinases, and determination of the active concentration of protein kinases binding to the probe. Bisubstrate-analog character of the probe enables the simultaneous evaluation of inhibitors targeted to both ATP binding site and substrate protein/peptide binding domain of the kinase. High affinity of the probe (Kd = 1.0 nM towards cAMP-dependent protein kinase) affords the application of the enzymes at low concentration which leads to the substantial decrease of the consumption of the kinase. Due to the ability of the conjugates of oligo(D-arginine) with a ATP binding site targeted inhibitors of this invention to bind with high affinity to a wide spectrum of (basophilic) kinases, a single Fluorescent probe is applicable for assessment of inhibitory potency of compounds towards a great number of protein kinases.

Classes IPC  ?

• C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
• A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament

Abrégé

A self- sensing actuator of electroactive polymer material such as ionic polymer-metal compound comprises a rigidly fixed part (4) and a moveable part (5) connected to each other. A control signal contact pair (2) for applying a control voltage to the actuator and a first sensor signal contact pair (3) are attached to the moveable part of the actuator. A second sensor signal contact pair (1) for obtaining a reference potential is attached to the rigidly fixed part of the actuator. The shape change of the moveable part during operation of the actuator is determined from the difference of the signals at the two sensor signals contact pairs. A method for controlling the shape of the actuator is also disclosed.

Classes IPC  ?

• H02N 2/00 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction
• H01L 41/08 - Eléments piézo-électriques ou électrostrictifs