A contactless system for assessing tissue viability and other hemodynamic parameters includes one or more light sources configured to emit lights at a predetermined wavelength sensitive to hemoglobin concentration associated with spontaneous hemodynamic oscillations at tissue in a predetermined area of a human subject. One or more polarizers are each coupled to one or more of the one or more light sources and are configured to polarize the light to a polarized state such that the polarized light in the polarized state diffuses into the tissue in the predetermined area at a predetermined depth and the polarized light is maintained in the polarized state at the predetermined depth. One or more detectors each including a detector polarizer coupled thereto are configured to discriminate the light maintained in the polarized state and at the predetermined depth and are configured to generate a plurality of frames of the tissue in the predetermined area at the predetermined depth. A controller is coupled to the one or more light sources and the one or more detectors. The controller is configured to: acquire the plurality of frames, select a region of interest having the same coordinates for each of the plurality of frames, average the number of pixels within each region of interest to create a raw reference signal, detrend the raw reference signal to create a detrended raw reference signal, perform frequency domain analysis of the detrended raw reference signal, identify a frequency band of interest associated with the spontaneous hemodynamic oscillations, and perform an inverse fast Fourier transform within the frequency band of interest to generate a reference signal indicative of blood volume oscillations at a selected spontaneous hemodynamic oscillation. For each sample of the reference signal at a predetermined point in time, the controller multiplies the sample by each pixel of a frame at the same predetermined point in time to generate a three-dimensional coordinate matrix including a plurality of correlation matrix frames at each predetermined point in time. The controller adds the plurality of correlation matrix frames at each predetermined point in time to generate a two-dimensional hemodynamic map indicative of the strength of the spontaneous hemodynamic oscillation to assess the viability of the tissue in the predetermined area.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/349 - Détection de paramètres spécifiques du cycle de l'électrocardiogramme
A system for cooling the brain of a human subject, includes a cooling subsystem which inputs a flow of air or breathable gas, cool the air or breathable gas, and output cooled air or breathable gas which is delivered to a human subject. A flow control device controls a flow rate of the flow of the air or breathable gas input to the cooling subsystem and a flow rate of the cooled air or breathable gas delivered to the human subject. One or more flow rate sensors measure at least a flow rate of flow of cooled air or breathable gas. One or more temperature sensors measure at least a temperature of a brain and the temperature of the flow of cooled air or breathable gas. A controller adjusts a cooling rate, the temperature, and the flow rate of flow of cooled air or breathable gas delivered to the human subject to cool the brain of the human subject.
A61F 7/00 - Appareils de chauffage ou de refroidissement pour traitement médical ou thérapeutique du corps humain
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
A61M 16/06 - Masques respiratoires ou pour l'anesthésie
A61M 16/10 - Préparation de gaz ou vapeurs à respirer
A61B 5/01 - Mesure de la température de parties du corps
A61M 5/44 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour refroidir ou pour chauffer les dispositifs ou les agents
3.
Contactless system and method for assessing tissue viability and other hemodynamic parameters
A contactless system for assessing tissue viability and other hemodynamic parameters includes one or more light sources configured to emit lights at a predetermined wavelength sensitive to hemoglobin concentration associated with spontaneous hemodynamic oscillations at tissue in a predetermined area of a human subject. One or more polarizers are each coupled to one or more of the one or more light sources and are configured to polarize the light to a polarized state such that the polarized light in the polarized state diffuses into the tissue in the predetermined area at a predetermined depth and the polarized light is maintained in the polarized state at the predetermined depth. One or more detectors each including a detector polarizer coupled thereto are configured to discriminate the light maintained in the polarized state and at the predetermined depth and are configured to generate a plurality of frames of the tissue in the predetermined area at the predetermined depth. A controller is coupled to the one or more light sources and the one or more detectors. The controller is configured to: acquire the plurality of frames, select a region of interest having the same coordinates for each of the plurality of frames, average the number of pixels within each region of interest to create a raw reference signal, detrend the raw reference signal to create a detrended raw reference signal, perform frequency domain analysis of the detrended raw reference signal, identify a frequency band of interest associated with the spontaneous hemodynamic oscillations, and perform an inverse fast Fourier transform within the frequency band of interest to generate a reference signal indicative of blood volume oscillations at a selected spontaneous hemodynamic oscillation. For each sample of the reference signal at a predetermined point in time, the controller multiplies the sample by each pixel of a frame at the same predetermined point in time to generate a three-dimensional coordinate matrix including a plurality of correlation matrix frames at each predetermined point in time. The controller adds the plurality of correlation matrix frames at each predetermined point in time to generate a two-dimensional hemodynamic map indicative of the strength of the spontaneous hemodynamic oscillation to assess the viability of the tissue in the predetermined area.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
A61B 5/349 - Détection de paramètres spécifiques du cycle de l'électrocardiogramme
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base, a restrictive distal opening which is stretchable to larger sizes, an internal strut structure, and an external stent structure.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61F 2/82 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p. ex. stents
A61M 29/02 - Dilatateurs gonflablesDilatateurs faits de matériaux dilatables
5.
SENSOR APPARATUS FOR SENSING CHARACTERISTIC OF FLUID, AND METHOD
A sensor apparatus includes a conduit receiver having an opening with a height that is greater than its width, such that the opening receives a portion of a fluid conduit with a diameter greater than the width of the opening. The fluid conduit is for simultaneously transporting at least a first fluid and a second fluid. A sensor is disposed adjacent to the opening in the conduit receiver and configured to detect at least one characteristic of at least one of the first fluid and the second fluid. A sensing height of the sensor is greater than the width of the opening of the conduit receiver. A processor is configured to receive signals output from the sensor and to make a determination related to the first fluid and the second fluid based on the received signals. A method is described for conducting such sensing.
An apparatus for exchanging small molecules with blood has a channel with a fluid- contacting surface having an affinity to one of blood and a carrier fluid, and further has a flow control device that controls a flow rate of the blood and the carrier fluid through the channel to create a stable bolus flow. An apparatus for exchanging small molecules with blood has a channel that includes a portion that provides a non-linear flow path configured to cause microcirculation. An apparatus for exchanging small molecules with blood has a channel with a surface that has an affinity to one of blood and a carrier fluid in the channel, and a fluid guide disposed in the channel that has an affinity to the other of the blood and carrier fluid. An apparatus for exchanging small molecules with blood has a separation device or section for separating blood and a carrier fluid.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
F15D 1/02 - Action sur l'écoulement des fluides dans les tuyaux ou les conduits
7.
SYSTEM AND METHOD FOR DETECTING AND/OR MONITORING THE PRESENCE OF AT LEAST ONE OF PNEUMOTHORAX, HEMOPNEUMOTHORAX, OR HEMOTHORAX IN A LIVING SUBJECT USING ONE OR MORE LIGHT SOURCES AND ONE OR MORE LIGHT DETECTORS
A system for detecting and/or monitoring at least one of pneumothorax,hemopneumolhorax, or hemothorax using one or more light sources and one or more lightdetectors. The system includes one or more light sources adapted to be placed on skirt of aliving subject The one or more tight detectors are adapted to be placed on the skin of theliving subject. A processing subsystem is coupled to the one or1 more light sources and theone or rnore tight detectors detects and/or monitors the presence of at least one ofpneumothorax, hen»pneumothorax, or hemothorax in the living subject.
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/083 - Mesure du taux de métabolisme en utilisant un essai respiratoire, p. ex. mesure du taux de consommation d'oxygène
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
A61B 5/1477 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques non invasifs
8.
SYSTEM AND METHOD FOR DETECTING AND/OR MONITORING THE PRESENCE OF AT LEAST ONE OF PNEUMOTHORAX, HEMOPNEUMOTHORAX, OR HEMOTHORAX IN A LIVING SUBJECT USING ONE OR MORE LIGHT SOURCES AND ONE OR MORE LIGHT DETECTORS
A system for detecting and/or monitoring at least one of pneumothorax, hemopneumothorax, or hemothorax using one or more light sources and one or more light detectors. The system includes one or more light sources adapted to be placed on skin of a living subject. The one or more light detectors are adapted to be placed on the skin of the living subject. A processing subsystem is coupled to the one or more light sources and the one or more light detectors detects and/or monitors the presence of at least one of pneumothorax, hemopneumothorax, or hemothorax in the living subject.
A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base and a restrictive distal opening which is stretchable to larger sizes. A self-expanding frame is attached to the proximal base of the membrane for securing the membrane within the pulmonary artery.
A61F 2/82 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p. ex. stents
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61M 29/02 - Dilatateurs gonflablesDilatateurs faits de matériaux dilatables
A system for non-invasively determining an indication and/or an assessment of intracranial pressure (ICP) is featured. The system includes at least one intracranial light source adapted to be placed on skin above a cranium of a living subject configured to emit light which penetrates the cranium and targets intracranial space of a living subject. The system includes a least one extracranial light source adapted to be placed on skin above a predetermined area of the living subject configured to emit light which penetrates and targets extracranial space of the living subject. A detector subsystem including at least a first detector is configured to detect reflected light from the intracranial space and the extracranial space and is configured to output intracranial output signals associated with light detected from the intracranial space and/or output extracranial output signals associated with light detected from the extracranial space. A processing subsystem is coupled to the at least one intracranial light source, the at least one extracranial light source, and the detector subsystem. The processing subsystem is configured to determine intracranial oxygen saturation and extracranial oxygen saturation and non-invasively determine an indication and/or an assessment of ICP using a ratio of the intracranial oxygen saturation to the extracranial oxygen saturation.
A system for noninvasively measuring blood alcohol concentration using light includes one or more emitters each configured to emit light in the near infrared or infrared light spectrum at one or more wavelengths that respond to varied chromophore concentrations of ethanol and water in blood of a human subject. One or more detectors is configured to detect light emitted at the one or more wavelengths and output a representation of a photoplethysmography (PPG) waveform for one or more of the one or more wavelengths. A processing subsystem is coupled to the one or more emitters and the one or more detectors. The processing subsystem is configured to determine a measure of an amplitude of the representation of the PPG waveform for each of the one or more wavelengths and determine the blood alcohol concentration by referencing the measured amplitude for each of the one or more wavelengths to a molar absorptivity plot which indicates a measure of the absorption or scattering at alcohol and water solutions ranging between a solution of 100% alcohol and a solution of 100% water.
A contactless system for assessing and/or determining hemodynamic parameters and/or vital signs is featured. The system includes one or more contactless light sources configured to emit light incident on a moving living subject at one more wavelengths absorbed by one or more chromophores associated with spontaneous hemodynamic oscillations in a predetermined area of the living subject. The system includes a camera subsystem including one or more cameras configured to receive reflected light from the predetermined area of the moving living subject and configured to track motion of the predetermined area of the living subject within a field of view of the camera subsystem and configured to generate a time sequence of images of the predetermined area of the living subject. A controller is coupled the one or more light sources and the camera subsystem and is configured to acquire the time sequence of images and configured to generate one or more non-contact PPG waveforms and to assess and/or and determine one or hemodynamic parameters and/or vital signs from the one or more non-contact PPG waveforms.
A system for non-invasively determining intracranial pressure (ICP) is disclosed. The system includes an intracranial light source for placement on skin above a subject's cranium to emit light penetrating the cranium, targeting the subject's intracranial space. The system includes an extracranial light source for predetermined placement on the subject's skin to emit light penetratinhg and targeting the subject's extracranial space. A detector subsystem detects light reflected from the intracranial space and the extracranial space and outputs intracranial output signals associated with light detected from the intracranial space and/or extracranial output signals associated with light detected from the extracranial space. A processing subsystem, coupled to the intracranial light source, extracranial light source, and the detector subsystem, determines intracranial oxygen saturation and extracranial oxygen saturation and determines an indication and/or assessment of ICP using a ratio of the intracranial oxygen saturation to the extracranial oxygen saturation.
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/03 - Mesure de la pression des fluides à l'intérieur du corps autre que la pression du sang, p. ex. de la pression cérébrale
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
G01N 21/359 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge proche
14.
System and method for non-invasively determining an indication and/or an assessment of intracranial pressure
A system for non-invasively determining an indication and/or an assessment of intracranial pressure (ICP) is featured. The system includes at least one intracranial light source adapted to be placed on skin above a cranium of a living subject configured to emit light which penetrates the cranium and targets intracranial space of a living subject. The system includes at least one extracranial light source adapted to be placed on skin above a predetermined area of the living subject configured to emit light which penetrates and targets extracranial space of the living subject. A detector subsystem including at least a first detector is configured to detect reflected light from the intracranial space and the extracranial space and is configured to output intracranial output signals associated with light detected from the intracranial space and/or output extracranial output signals associated with light detected from the extracranial space. A processing subsystem is coupled to the at least one intracranial light source, the at least one extracranial light source, and the detector subsystem. The processing subsystem is configured to determine intracranial oxygen saturation and extracranial oxygen saturation and non-invasively determine an indication and/or an assessment of ICP using a ratio of the intracranial oxygen saturation to the extracranial oxygen saturation.
A contactless system for assessing and/or determining hemodynamic parameters and/or vital signs is featured. The system includes one or more contactless light sources configured to emit light incident on a moving living subject at one more wavelengths absorbed by one or more chromophores associated with spontaneous hemodynamic oscillations in a predetermined area of the living subject. The system includes a camera subsystem including one or more cameras configured to receive reflected light from the predetermined area of the moving living subject and configured to track motion of the predetermined area of the living subject within a field of view of the camera subsystem and configured to generate a time sequence of images of the predetermined area of the living subject. A controller is coupled the one or more light sources and the camera subsystem and is configured to acquire the time sequence of images and configured to generate one or more non-contact PPG waveforms and to assess and/or and determine one or hemodynamic parameters and/or vital signs from the one or more non-contact PPG waveforms. One or more polarizers are preferably each coupled to one of the one or more light sources are preferably configured to polarize the light to a polarized state such that the polarized light in the polarized state diffuses into the tissue in the predetermined area at a predetermined depth range and the polarized light is maintained in the polarized state at the predetermined depth range. A detector polarizer is preferably coupled to each of the one or more cameras and is configured to discriminate the light maintained in the polarized state and at the predetermined depth range and configured to generate the time sequence of images of the predetermined area with improved signal quality of the resulting non-contact PPG waveform.
A system for non-invasively measuring blood volume oscillations inside a cranium of a human subject. The system includes a first light source adapted to be placed on the skin above the cranium of the human subject configured to emit light which penetrates a superficial space outside the cranium. A detector is adapted to be placed on the skin above the cranium of the human subject spaced from the first light source to detect light which reflects from the superficial space outside the cranium and output superficial output signals. A second light source is adapted be placed on the skin above the cranium configured to emit light which penetrates through the superficial space outside the cranium to inside the cranium and causes the detector to detect light which reflects from inside the cranium and output cranial output signals. The system and method to measure blood volume oscillations inside the cranium of a human subject may use the measured blood volume oscillation to non-invasively measure ICR.
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
A system for non-invasively measuring blood volume oscillations inside a cranium of a human subject. The system includes a first light source adapted to be placed on the skin above the cranium of the human subject configured to emit light which penetrates a superficial space outside the cranium. A detector is adapted to be placed on the skin above the cranium of the human subject spaced from the first light source by a first predetermined separation distance that causes the detector to detect light which reflects from the superficial space outside the cranium and output superficial output signals. A second light source is adapted be placed on the skin above the cranium configured to emit light which penetrates through the superficial space outside the cranium to inside the cranium and the detector is spaced from the second light source by a second predetermined separation distance that causes the detector to detect light which reflects from inside the cranium and output cranial output signals. A processing subsystem is coupled to the first light source, the second light source, and the detector. The processing subsystem is configured to alternately enable the first light source and the second light source and alternately enable the detector to detect the light which reflects from the superficial space outside the cranium and the light which reflects from inside the cranium to generate the superficial output signals and cranial output signals. The processing subsystem is responsive to the superficial output signals and the cranial output signals and is further configured to reduce contributions from the superficial space existing in the cranial output signals and generate corrected cranial output signals indicative of blood volume oscillations inside the cranium. The system and method to measure blood volume oscillations inside the cranium of a human subject may use the measured blood volume oscillation to non-invasively measure ICP.
A system to electronically coordinate and document patient care regardless of physical setting. The system includes a wearable subsystem attached to a patient at the point of injury and configured to remain attached to the patient at the point of injury and during one or more encounters with medical personnel or to a time the patient reaches a clinical health care facility. The wearable subsystem is configured to store patient identification information and critical health care information received via wireless communication from an end user computing device at the point of injury and is configured to store added health care information provided by medical personnel from or at the point of injury and during the one or more encounters with the medical personnel or to a time the patient reaches a clinical care facility.
G16H 10/65 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients stockées sur des supports d’enregistrement portables, p. ex. des cartes à puce, des étiquettes d’identification radio-fréquence [RFID] ou des CD
H04W 4/80 - Services utilisant la communication de courte portée, p. ex. la communication en champ proche, l'identification par radiofréquence ou la communication à faible consommation d’énergie
A system to electronically coordinate and document patient care regardless of physical setting. The system includes a wearable subsystem attached to a patient at the point of injury and configured to remain attached to the patient at the point of injury and during one or more encounters with medical personnel or to a time the patient reaches a clinical health care facility. The wearable subsystem is configured to store patient. identification information and critical health care information received via wireless communication From an end user computing device at the point of injury and is configured to store added health care information provided by medical personnel from or at the point of injury and during the one or more encounters with the medical personnel or to a time the patient reaches a clinical care facility.
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
A61B 5/01 - Mesure de la température de parties du corps
G05B 1/01 - Éléments de comparaison, c.-à-d. éléments pour effectuer la comparaison directement ou indirectement entre une valeur désirée et des valeurs existantes ou prévues électriques
20.
System and method for noninvasively measuring blood alcohol concentration using light
A system for noninvasively measuring blood alcohol concentration using light includes one or more emitters each configured to emit light in the near infrared or infrared light spectrum at one or more wavelengths that respond to varied chromophore concentrations of ethanol and water in blood of a human subject. One or more detectors is configured to detect light emitted at the one or more wavelengths and output a representation of a photoplethysmography (PPG) waveform for one or more of the one or more wavelengths. A processing subsystem is coupled to the one or more emitters and the one or more detectors. The processing subsystem is configured to determine a measure of an amplitude of the representation of the PPG waveform for each of the one or more wavelengths and determine the blood alcohol concentration by referencing the measured amplitude for each of the one or more wavelengths to a molar absorptivity plot which indicates a measure of the absorption or scattering at alcohol and water solutions ranging between a solution of 100% alcohol and a solution of 100% water.
A system for noninvasively measuring blood alcohol concentration using light includes one or more emitters each configured io emir light in the near infrared or infrared Sight spectrum at one or more wavelengths that respond to varied chromophore concentrations of ethanol and water in blood of a human subject. One or more detectors is configured to detect light emitted at the one or more wavelengths and output a representation of a phatopleihysmography (PPG) waveform for one or more of the one or more wavelengths. A processing subsystem is coupled to the one or more emitters and the one or more detectors. The processing subsystem is configured to determine a measure of an amplitude of the representation of the PPG waveform for each of the one or more wavelengths and determine the blood alcohol concentration by referencing the measured amplitude for each of the one or more wavelengths to a molar absorptivity plot which indicates a measure of the absorption or scattering at alcohol and water solutions ranging between a solution of 100% alcohol and a solution of 100% water.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
B60K 28/02 - Dispositifs de sécurité pour la commande des ensembles de propulsion spécialement adaptés aux véhicules ou aménagés dans ceux-ci, p. ex. empêchant l'alimentation en carburant ou l'allumage en cas de danger sensibles à des conditions relatives au conducteur
B60K 28/06 - Dispositifs de sécurité pour la commande des ensembles de propulsion spécialement adaptés aux véhicules ou aménagés dans ceux-ci, p. ex. empêchant l'alimentation en carburant ou l'allumage en cas de danger sensibles à des conditions relatives au conducteur sensibles à l'incapacité du conducteur
B60W 50/08 - Interaction entre le conducteur et le système d'aide à la conduite
B60W 50/14 - Moyens d'information du conducteur, pour l'avertir ou provoquer son intervention
22.
Transcatheter device and minimally invasive method for constricting and adjusting blood flow through a blood vessel
A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base and a restrictive distal opening which is stretchable to larger sizes. A self-expanding frame is attached to the proximal base of the membrane for securing the membrane within the pulmonary artery.
A61F 2/82 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p. ex. stents
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61M 29/02 - Dilatateurs gonflablesDilatateurs faits de matériaux dilatables
A system for cooling the brain of a human subject, includes a cooling subsystem which inputs a flow of air or breathable gas, cool the air or breathable gas, and outputs cooled air or breathable gas which is delivered to a human subject. A flow control device controls a flow rate of the flow of the air or breathable gas input to the cooling subsystem and a flow rate of the cooled air or breathable gas delivered to the human subject. One or more flow rate sensors measure at least a flow rate of flow of cooled air or breathable gas. One or more temperature sensors measure at least a temperature of a brain and the temperature of the flow of cooled air or breathable gas. A controller adjusts a cooling rate, the temperature, and the flow rate of flow of cooled air or breathable gas delivered to the human subject to cool the brain of the human subject.
A61M 16/10 - Préparation de gaz ou vapeurs à respirer
A61M 16/06 - Masques respiratoires ou pour l'anesthésie
A61F 7/00 - Appareils de chauffage ou de refroidissement pour traitement médical ou thérapeutique du corps humain
A61B 5/01 - Mesure de la température de parties du corps
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
A61M 5/44 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour refroidir ou pour chauffer les dispositifs ou les agents
Apparatuses for flowing multiple fluids in a single channel while substantially maintaining fluid separation are disclosed. In one configuration, the apparatus includes a first internal surface portion with an affinity to a first fluid and a second internal surface portion with an affinity to a second fluid. In another configuration, the apparatus includes a first fluid channel portion, a second fluid channel portion wrapped helically around the first fluid channel portion, and an opening therebetween. Also disclosed is an apparatus for maintaining substantially even fluid flow in fluid pathways having a first flow resistor portion, a second flow resistor portion, and a fluid channel therebetween.
F15B 21/06 - Utilisation de fluides particuliers, p. ex. de métal liquideAdaptations particulières des systèmes à pression de fluide, ou commande de leurs éléments, pour l'utilisation de tels fluides
F15D 1/06 - Action sur l'écoulement des fluides dans les tuyaux ou les conduits en agissant sur la couche-limite
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (USA)
Inventeur(s)
Pierro, Michele
Quinn, Kyle
Woessner, Alan
Abrégé
A contactless system for assessing tissue viability and other hemodynamic parameters includes one or more light sources configured to emit lights at a predetermined wavelength sensitive to hemoglobin concentration associated with spontaneous hemodynamic oscillations at tissue in a predetermined area of a human subject. One or more polarizers are each coupled to one or more of the light sources and are configured to polarize the light to a polarized stale such that the polarized light in the polarized state diffuses into the tissue in the predetermined area at a predetermined depth and the polarized light is maintained in the polarized state at the predetermined depth. One or more detectors, each including a detector polarizer coupled thereto are configured to discriminate the light maintained in the polarized state and at the predetermined depth, are configured to generate a plurality of frames of the tissue in the predetermined area at the predetermined depth.
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
26.
Contactless system and method for assessing tissue viability and other hemodynamic parameters
The Board of Trustees of The University of Arkansas (USA)
Inventeur(s)
Pierro, Michele
Quinn, Kyle
Woessner, Alan
Abrégé
A contactless system for assessing tissue viability and other hemodynamic parameters includes one or more light sources configured to emit lights at a predetermined wavelength sensitive to hemoglobin concentration associated with spontaneous hemodynamic oscillations at tissue in a predetermined area of a human subject. One or more polarizers are each coupled to one or more of the one or more light sources and are configured to polarize the light to a polarized state such that the polarized light in the polarized state diffuses into the tissue in the predetermined area at a predetermined depth and the polarized light is maintained in the polarized state at the predetermined depth. One or more detectors each including a detector polarizer coupled thereto are configured to discriminate the light maintained in the polarized state and at the predetermined depth and are configured to generate a plurality of frames of the tissue in the predetermined area at the predetermined depth. A controller is coupled to the one or more light sources and the one or more detectors. The controller is configured to: acquire the plurality of frames, select a region of interest having the same coordinates for each of the plurality of frames, average the number of pixels within each region of interest to create a raw reference signal, detrend the raw reference signal to create a detrended raw reference signal, perform frequency domain analysis of the detrended raw reference signal, identify a frequency band of interest associated with the spontaneous hemodynamic oscillations, and perform an inverse fast Fourier transform within the frequency band of interest to generate a reference signal indicative of blood volume oscillations at a selected spontaneous hemodynamic oscillation. For each sample of the reference signal at a predetermined point in time, the controller multiplies the sample by each pixel of a frame at the same predetermined point in time to generate a three-dimensional coordinate matrix including a plurality of correlation matrix frames at each predetermined point in time. The controller adds the plurality of correlation matrix frames at each predetermined point in time to generate a two-dimensional hemodynamic map indicative of the strength of the spontaneous hemodynamic oscillation to assess the viability of the tissue in the predetermined area.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
27.
SYSTEM AND METHOD FOR COOLING THE BRAIN OF A HUMAN SUBJECT
A system for cooling the brain of a human subject, including a cooling subsystem to input a flow of air or breathable gas, cool the air or breathable gas, and output cooled air or breathable gas to a line coupled to a device adapted to deliver the cooled gas to a human. A flow control device controls a flow rate of the flow of the gas input to the cooling subsystem and a flow rate of the cooled gas output to the line. One or more How rate sensors measure a flow rate of the flow of gas. One or more temperature sensors measure a temperature of a brain or a brain correlative site of the human subject and the temperature of the cooled gas. A controller adjusts a cooling rate, the temperature, and the flow rate of flow of cooled gas delivered to the human subject.
A system for cooling the brain of a human subject, includes a cooling subsystem which inputs a flow of air or breathable gas, cool the air or breathable gas, and output cooled air or breathable gas which is delivered to a human subject. A flow control device to controls a flow rate of the flow of the air or breathable gas input to the cooling subsystem and a flow rate of the cooled air or breathable gas delivered to the human subject. One or more flow rate sensors measure at least a flow rate of flow of cooled air or breathable gas. One or more temperature sensors measure at least a temperature of a brain and the temperature of the flow of cooled air or breathable gas. A controller adjusts a cooling rate, the temperature, and the flow rate of flow of cooled air or breathable gas delivered to the human subject to cool the brain of the human subject.
A system for cooling the brain of a human subject* the system including a cooling subsystem configured to input a flow of air or breathable gas, cool the air or breathable gas, and output cooled air or breathable gas to a line coupled to a device adapted to deliver the cooled air or breathable gas to a human subject. A flow control device coupled to the cooling subsystem is configured to control a flow rate of the flow of the air or breathable gas input to the cooling subsystem and a flow rate of the cooled air or breathable gas output to the line. One or more How rate sensors coupled to the cooling subsystem are configured to measure at least a flow rate of flow of cooled air or breathable gas. One or more temperature sensors are configured to measure at least a temperature of a brain or a brain correlative site of the human subject and the temperature of the flow of cooled air or breathable gas. A controller is coupled to the cooling subsystem, the flow control device, the one or more flow rate sensors, and the one or more temperature sensors and is configured to adjust a cooling rate, the temperature, and the flow rate of flow of cooled air or breathable gas delivered to the human subject based on at least the measured temperature of the brain or the brain correlative site and the measured flow rate of the flow of cooled air or breathable gas to cool the brain of the human subject.
UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER (USA)
Inventeur(s)
Cohen, Ian
Hirschman, Gordon, B.
Galea, Anna, M
Ma, Hsiang-Wei
Yavuz, Metin
Adams, Linda
Ersen, Ali
Abrégé
A system for measuring and controlling foot temperature. The system comprises a heating or cooling device including one or more sealed fluidic pathways having a cooling or heating fluid therein and disposed in or on an article of footwear or a sock. A pumping device coupled to the heating or cooling device is configured to circulate the fluid in the one or more sealed fluidic pathways, A heat exchanger coupled to the heating or cooling device is configured to remove or add heat from or to the fluid in the one or more sealed fluidic pathways. A controller coupled to the pumping device and the heat exchanger is configured to control the pumping device and the heat exchanger to cool or heat a foot located inside the article of footwear or the sock.
University of North Texas Health Science Center (USA)
Inventeur(s)
Cohen, Ian
Hirschman, Gordon B.
Galea, Anna M
Ma, Hsiang-Wei
Yavuz, Metin
Adams, Linda
Ersen, Ali
Abrégé
A system for measuring and controlling foot temperature. The system comprises a heating or cooling device including one or more sealed fluidic pathways having a cooling or heating fluid therein and disposed in or on an article of footwear or a sock. A pumping device coupled to the heating or cooling device is configured to circulate the fluid in the one or more sealed fluidic pathways. A heat exchanger coupled to the heating or cooling device is configured to remove or add heat from or to the fluid in the one or more sealed fluidic pathways. A controller coupled to the pumping device and the heat exchanger is configured to control the pumping device and the heat exchanger to cool or heat a foot located inside the article of footwear or the sock.
A prosthetic socket cooling system and method includes a thermally conductive heat spreader including a curved shaped portion configured to maximize contact with a residual limb of a user. A heat extraction subsystem is coupled through a wall of the prosthetic socket and to the thermally conductive heat spreader and is configured to maintain a desired temperature inside the prosthetic socket.
A61F 7/00 - Appareils de chauffage ou de refroidissement pour traitement médical ou thérapeutique du corps humain
H01L 35/30 - DISPOSITIFS À SEMI-CONDUCTEURS; DISPOSITIFS ÉLECTRIQUES À L'ÉTAT SOLIDE NON PRÉVUS AILLEURS - Détails fonctionnant exclusivement par effet Peltier ou effet Seebeck caractérisés par les moyens d'échange de chaleur à la jonction
A61F 2/60 - Jambes ou pieds artificiels ou leurs parties
A61F 2/78 - Moyens pour protéger les prothèses ou pour les assujettir au corps, p. ex. bandages, harnais, courroies ou bas pour moignons
A61F 7/02 - Compresses ou cataplasmes procurant de la chaleur ou du froid
A61F 5/01 - Dispositifs orthopédiques, p. ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles
33.
Non-invasive intracranial pressure monitoring system and method thereof
A system which includes a first sensor placed proximate to a perfusion field of an artery receiving blood which emanates from the cranial cavity is configured to monitor pulsations of the artery receiving blood which emanates from the cranial cavity artery. A second sensor placed proximate to a perfusion field of an artery which does not receive blood emanating from the cranial cavity configured to monitor pulsations of the artery which does not receive blood emanating from the cranial cavity. A third sensor configured to monitor pulsations of a distal artery. A processing system responsive to signals from the first, second, and third sensors is configured to determine intracranial pressure.
A contactless system for measuring and continuously monitoring arterial blood pressure includes a light source configured to illuminate light having at least one predetermined wavelength at a predetermined area of a human subject having an artery therein. A detector responsive to reflected light from the predetermined area is configured to continuously acquire images of the artery in the predetermined area.
A contactless system for measuring and continuously monitoring arterial blood pressure includes a light source configured to illuminate light having at least one predetermined wavelength at a predetermined area of a human subject having an artery therein. A detector responsive to reflected light from the predetermined area to continuously acquire images of the artery in the predetermined area. A processor processes the images and determines when an image at a proximal location of the predetermined area is darker indicating transition of a pulse wave into the artery at the proximal location and at a proximal time and when an image at a distal location of the predetermined area is darker indicating transition of the pulse wave into the artery at a distal location at a distal time to contactlessly and continuously calculate the arterial blood pressure for each cardiac cycle of the human subject.
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (USA)
Inventeur(s)
Galea, Anna M.
Cevette, Michael J.
Pradhan, Gaurav N.
Stepanek, Jan
Cocco, Daniela
Oakley Holbert, Sarah
Scheibler, Linsey S.
Bogle, Jamie M.
Abrégé
A system for suppressing vestibular activity of a human subject includes an electronics module configured to generate one or more electrical stimulation signals. A plurality of electrodes each placed proximate a predetermined location on a head of a human subject is configured to deliver the one or more electrical stimulation signals to the predetermined location to suppress vestibular activity of the human subject.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
37.
System and method for suppressing vestibular activity of a human subject
Mayo Foundation For Medical Education and Research (USA)
Inventeur(s)
Galea, Anna M
Cevette, Michael J.
Pradhan, Gaurav N.
Stepanek, Jan
Cocco, Daniela
Oakley Holbert, Sarah
Scheibler, Linsey S.
Bogle, Jamie M.
Abrégé
A system for suppressing vestibular activity of a human subject includes an electronics module configured to generate one or more electrical stimulation signals. A plurality of electrodes each placed proximate a predetermined location on a head of a human subject is configured to deliver the one or more electrical stimulation signals to the predetermined location to suppress vestibular activity of the human subject.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/20 - Application de courants électriques par électrodes de contact courants continus ininterrompus
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (USA)
Inventeur(s)
Galea, Anna, M.
Cevette, Michael, J.
Pradhan, Gaurav, N.
Stepanek, Jan
Cocco, Daniela
Oakley Holbert, Sarah
Scheibler, Linsey, S.
Bogle, Jamie, M.
Abrégé
A system for suppressing vestibular activity of a human subject includes an electronics module configured to generate one or more electrical stimulation signals. A plurality of electrodes each placed proximate a predetermined location on a head of a human subject is configured to deliver the one or more electrical stimulation signals to the predetermined location to suppress vestibular activity of the human subject.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
39.
TRANSCATHETER DEVICE AND MINIMALLY INVASIVE METHOD FOR CONSTRICTING AND ADJUSTING BLOOD FLOW THROUGH A BLOOD VESSEL
A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base and a restrictive distal opening which is stretchable to larger sizes. A self-expanding frame is attached to the proximal base of the membrane for securing the membrane within the pulmonary artery.
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base and a restrictive distal opening which is stretchable to larger sizes. A self-expanding frame is attached to the proximal base of the membrane for securing the membrane within the pulmonary artery.
A61F 2/82 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p. ex. stents
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61M 29/02 - Dilatateurs gonflablesDilatateurs faits de matériaux dilatables
A system which includes a first sensor placed proximate to a perfusion field of an artery receiving blood which emanates from the cranial cavity is configured to monitor pulsations of the artery receiving blood which emanates from the cranial cavity artery. A second sensor placed proximate to a perfusion field of an artery which does not receive blood emanating from the cranial cavity configured to monitor pulsations of the artery which does not receive blood emanating from the cranial cavity. A third sensor configured to monitor pulsations of a distal artery. A processing system responsive to signals from the first, second, and third sensors is configured to determine intracranial pressure.
A flow rate sensor system for non-invasively measuring the flow rate of a bodily fluid. The system includes an encapsulated implant having a flow tube having an inlet and an outlet configured to receive a flow of a bodily fluid. A heating element externally coupled to the flow tube is configured to dissipate heat at a predetermined rate over a predetermined amount of time. A temperature sensor externally coupled to the heating element is configured to measure a temperature rise of the heating element over the predetermined amount of time.
A flow rate sensor system for non-invasively measuring the flow rate of a bodily fluid. The system includes an encapsulated implant having a flow tube having an inlet and an outlet configured to receive a flow of a bodily fluid. A heating element externally coupled to the flow tube is configured to dissipate heat at a predetermined rate over a predetermined amount of time. A temperature sensor externally coupled to the heating element is configured to measure a temperature rise of the heating element over the predetermined amount of time.
An array of hollow fibers including a plurality of hollow fibers of a predetermined diameter configured to receive a gas having oxygen therein and transfer the oxygen to a fluid and/or transfer carbon dioxide in the fluid to a gas. The array is configured in a predetermined pattern having a predetermined packing density that is a fraction of a total cross-sectional area of the array occupied by the hollow fibers.
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
A system which includes a first sensor placed proximate to a perfusion field of an artery receiving blood which emanates from the cranial cavity is configured to monitor pulsations of the artery receiving blood which emanates from the cranial cavity artery. A second sensor placed proximate to a perfusion field of an artery which does not receive blood emanating from the cranial cavity and approximately the same distance from the heart as the first sensor configured to monitor pulsations of the artery which does not receive blood emanating from the cranial cavity. A third sensor placed distally from a heart is configured to monitor pulsations of a distal artery. A processing system responsive to signals from the first, second, and third sensors is configured to determine intracranial pressure.
A system which includes a first sensor placed proximate to a perfusion field of an artery receiving blood which emanates from the cranial cavity is configured to monitor pulsations of the artery receiving blood which emanates from the cranial cavity artery. A second sensor placed proximate to a perfusion field of an artery which does not receive blood emanating from the cranial cavity and approximately the same distance from the heart as the first sensor configured to monitor pulsations of the artery which does not receive blood emanating from the cranial cavity. A third sensor placed distally from a heart is configured to monitor pulsations of a distal artery. A processing system responsive to signals from the first, second, and third sensors is configured to determine intracranial pressure.
The invention generally relates to aptamers that bind CD271. In certain aspects, the invention provides an isolated nucleic acid ligand that binds to CD271, in which the nucleic acid ligand includes the nucleotide sequence of SEQ ID NO: 1 or the nucleotide sequence of SEQ ID NO: 2.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
48.
SYSTEM AND METHOD FOR DETERMINING A MEASURE OF THE RESISTANC E OF PERIPHERAL VASCULATURE
A system for determining the resistance of peripheral vasculature including a sensor configured to generate output signals proportional to the amount of blood in the peripheral vasculature over time, and a computer subsystem configured to determine the resistance of the peripheral vasculature in response to the output signals.
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
An orientation tracking system including a first tracking system subject to drift. A second tracking system is configured to provide an output for calibrating the first tracking system to reduce the drift of the first tracking system. The second tracking system includes at least one inclinometer, each inclinometer including a light source adjacent one side of the inclinometer, a light sensor adjacent an opposing side of the inclinometer, and a light obscuring material within the inclinometer for obscuring the light between the light source and light sensor to indicate an orientation of the inclinometer.
G01B 11/26 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer des angles ou des cônesDispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour tester l'alignement des axes
50.
Array of hollow fibers and a system and method of manufacturing same
An array of hollow fibers including a plurality of hollow fibers of a predetermined diameter configured to receive a gas having oxygen therein and transfer the oxygen to a fluid and/or transfer carbon dioxide in the fluid to a gas. The array is configured in a predetermined pattern having a predetermined packing density that is a fraction of a total cross-sectional area of the array occupied by the hollow fibers.
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
B01D 63/04 - Modules à fibres creuses comprenant plusieurs ensembles à fibres creuses
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
A two-stage system for oxygenating and removing carbon dioxide from a physiological fluid, including: a primary exchange module configured to receive a gas having oxygen therein and a carrier fluid having carbon dioxide therein. The primary exchange module is configured to transfer oxygen from the gas to the carrier fluid and transfer carbon dioxide from the carrier fluid to the gas to create an oxygen loaded carrier fluid and a carbon dioxide load gas. A secondary exchange module is configured to receive the oxygen loaded carrier fluid and a physiological fluid having the carbon dioxide therein. The secondary exchange module is configured to transfer the oxygen from the oxygen loaded carrier fluid to the physiological fluid and transfer carbon dioxide from the physiological fluid to the carrier fluid to create an oxygen loaded physiological fluid.
A61F 2/04 - Éléments ou organes creux ou tubulaires, p. ex. vessies, trachées, bronches ou voies biliaires
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid ligand of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate mixture of nucleic acids, in which the nucleic acids have different affinities for the target molecule, and separating in a single step nucleic acids that bind the target molecule with greatest affinity from nucleic acids that bind the target molecule with a lesser affinity and nucleic acids that do not bind the target molecule, thereby identifying the nucleic acid ligand of the target molecule.
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
brevets
