Produits et services

Automatic liquid-flow control machines and instruments; Dosage dispensers for measuring and dispensing portions of liquids, not for medical use; Medical laboratory research instruments for sample preparation; Scientific instrumentation for measuring liquids[not for medical use]; Scientific instrumentation for measuring volume[not for medical use]; Scientific instrumentation for measuring biological samples[not for medical use] Infusion pumps; Infusion sets

Abrégé

Methods of detection of congenital heart defect (CHD) in a newborn human patient, are provided according to aspects of the present disclosure which include: performing an assay for one or more biomarkers of CHD selected from the group consisting of: soluble Suppression of Tumorigenicity 2 protein (sST2), and Galectin-3 in a dried blood sample obtained from the newborn human patient, thereby determining a level of one or both biomarkers present in the dried blood sample. The determined level of the biomarker(s) present in the dried blood sample is compared with a standard representing a normal newborn control without CHD, thereby determining whether the determined level is increased or decreased compared to the standard, wherein an increased level of one or both biomarkers present in the dried blood sample, compared with a standard representing a normal newborn control without congenital heart defect, indicates detection of CHD in the newborn human patient.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux

Abrégé

Methods of detection of congenital heart defect (CHD) in a newborn human patient, are provided according to aspects of the present disclosure which include: performing an assay for one or more biomarkers of CHD selected from the group consisting of: soluble Suppression of Tumorigenicity 2 protein (sST2), and Galectin-3 in a dried blood sample obtained from the newborn human patient, thereby determining a level of one or both biomarkers present in the dried blood sample. The determined level of the biomarker(s) present in the dried blood sample is compared with a standard representing a normal newborn control without CHD, thereby determining whether the determined level is increased or decreased compared to the standard, wherein an increased level of one or both biomarkers present in the dried blood sample, compared with a standard representing a normal newborn control without congenital heart defect, indicates detection of CHD in the newborn human patient.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A method for applying pairwise differential privacy to variables in a data set is disclosed. The method includes designating a random instance seed value to a first data set variable in an original data set and designating the random instance seed value to at least one additional data set variable in the original data set if a high degree of correlation is identified between the first data set variable and the at least one additional data set variable. The method further includes determining an adaptive sensitivity parameter corresponding to the first data set variable and utilizing, by a noise generation manager, two or more among the first data set variable, the random instance seed value, and/or the adaptive sensitivity parameter to generate and apply additive noise to the first data set variable to produce a pseudonymized variable for inclusion in a pseudonymized data set associated with the original data set.

Classes IPC  ?

• G06F 17/18 - Opérations mathématiques complexes pour l'évaluation de données statistiques
• H04N 5/60 - Circuits de réception pour les signaux du canal son

Abrégé

The present disclosure relates to a method, system, and kit for analyzing a biological sample that has been dried on a sample carrier, the method comprising: a) creating a combination within a vessel, the combination comprising the sample carrier, an elution solution, and a reaction solution, wherein the sample carrier has not been subjected to incubation prior to creating the combination; and b) incubating the combination within the vessel to elute the biological sample from the sample carrier and to perform qPCR on the biological sample.

Classes IPC  ?

• C12Q 1/6851 - Amplification quantitative

Abrégé

A method for applying pairwise differential privacy to variables in a data set is disclosed. The method includes designating a random instance seed value to a first data set variable in an original data set and designating the random instance seed value to at least one additional data set variable in the original data set if a high degree of correlation is identified between the first data set variable and the at least one additional data set variable. The method further includes determining an adaptive sensitivity parameter corresponding to the first data set variable and utilizing, by a noise generation manager, two or more among the first data set variable, the random instance seed value, and/or the adaptive sensitivity parameter to generate and apply additive noise to the first data set variable to produce a pseudonymized variable for inclusion in a pseudonymized data set associated with the original data set.

Classes IPC  ?

• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p.ex. par clés ou règles de contrôle de l’accès

Produits et services

Diagnostic reagents for medical use; medical diagnostic reagents and assays for testing of body fluids; diagnostic preparations for medical or veterinary purposes; preparations for detecting genetic predispositions for medical purposes; reagents and media for medical and veterinary diagnostic purposes; reagents for medical use; reagents for use in diagnostic tests [for medical purposes]; reagents for use in diagnostic tests [for veterinary purposes]; reagents for use with analyzers [for medical purposes]; reagents for use with analyzers [for veterinary purposes]; immunoassay reagents for medical use; enzyme preparations for medical purposes. Medical and veterinary apparatus and instruments; analytical instruments for medical use; apparatus for use in medical analysis; apparatus for carrying-out diagnostic tests for medical purposes; instruments for use in medical analysis; diagnostic apparatus for medical purposes; diagnostic instruments for medical use; medical diagnostic apparatus for medical purposes; medical diagnostic instruments; testing instruments for medical diagnostic purposes; diagnostic testing apparatus for use in immunoassay procedures [medical]; diagnostic testing instruments for use in immunoassay procedure [medical]; diagnostic imaging apparatus for medical use; medical imaging apparatus; automated analyzers for body fluids [for medical use].

Abrégé

A lateral flow test strip reader (500) for reading an output of a lateral flow assay to determine a presence or absence of a target in a sample includes: a housing (510) having a lateral flow test strip receptacle (512) for receiving a lateral flow test strip (300) therein, the lateral flow test strip receptacle defining a test region and a control region for a lateral flow test strip; a light source (520) that generates an excitation light beam; an optical detector (540) configured to simultaneously detect an image comprising emission signals from the test region and the control region, and at least one lens (not shown) configured to direct the emission signals from at least one of the test region and the control region of the test strip to the optical detector, the at least one lens comprising an excitation light transmission region configured to transmit the excitation to the test strip, wherein the detected emission signals indicate a presence or absence of a target in the sample.

Classes IPC  ?

• G01N 21/84 - Systèmes spécialement adaptés à des applications particulières

Produits et services

Diagnostic reagents for medical use; medical diagnostic reagents and assays for testing of body fluids; diagnostic preparations for medical or veterinary purposes; preparations for detecting genetic predispositions for medical purposes; reagents and media for medical and veterinary diagnostic purposes; reagents for medical use; reagents for use in diagnostic tests for medical purposes; reagents for use in diagnostic tests for veterinary purposes; reagents for use with analyzers for medical purposes; reagents for use with analyzers for veterinary purposes; immunoassay reagents for medical use; enzyme preparations for medical purposes Medical and veterinary apparatus and instruments, namely, blood testing apparatus; analytical instruments for screening disorders in newborns based on blood samples for medical use; blood testing apparatus for use in medical analysis; genetic testing apparatus for carrying-out diagnostic tests for medical purposes; diagnostic instruments for detecting genetic predispositions for use in medical analysis; diagnostic apparatus for detecting genetic predispositions and screening disorders in newborns based on blood samples for medical purposes; diagnostic instruments for the analysis of body fluids for medical use; medical diagnostic apparatus for the analysis of body fluids for medical purposes; medical diagnostic instruments for the analysis of body fluids; testing instruments for the analysis of body fluids for medical diagnostic purposes; medical diagnostic testing apparatus for the analysis of body fluids for use in immunoassay procedures; medical diagnostic testing instruments for detecting genetic predispositions for use in immunoassay procedure; diagnostic imaging apparatus for medical use; medical imaging apparatus; automated analyzers for body fluids for medical use

Abrégé

A lateral flow test strip reader for reading an output of a lateral flow assay to determine a presence or absence of a target in a sample includes: a housing having a lateral flow test strip receptacle for receiving a lateral flow test strip therein, the lateral flow test strip receptacle defining a test region and a control region for a lateral flow test strip; a light source that generates an excitation light beam; at least one lens for optically expanding the excitation light beam in a direction across the test region and the control region such that the excitation light beam is configured to simultaneously impinge and excite both the test region and the control region; and an optical detector configured to simultaneously detect an image comprising emission signals from the test region and the control region, wherein the detected emission signals indicate a presence or absence of a target in the sample.

Classes IPC  ?

• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 21/64 - Fluorescence; Phosphorescence

Produits et services

Diagnostic reagents for medical use; Medical diagnostic reagents and assays for testing of body fluids; Diagnostic preparations for medical or veterinary purposes; Preparations for detecting genetic predispositions for medical purposes; Reagents and media for medical and veterinary diagnostic purposes; Reagents for medical use; Reagents for use in diagnostic tests [for medical purposes]; Reagents for use in diagnostic tests [for veterinary purposes]; Reagents for use with analyzers [for medical purposes]; Reagents for use with analyzers [for veterinary purposes]; Immunoassay reagents for medical use; Enzyme preparations for medical purposes. Medical and veterinary apparatus and instruments; Analytical instruments for medical use; Apparatus for use in medical analysis; Apparatus for carrying-out diagnostic tests for medical purposes; Instruments for use in medical analysis; Diagnostic apparatus for medical purposes; Diagnostic instruments for medical use; Medical diagnostic apparatus for medical purposes; Medical diagnostic instruments; Testing instruments for medical diagnostic purposes; Diagnostic testing apparatus for use in immunoassay procedures [medical]; Diagnostic testing instruments for use in immunoassay procedure [medical]; Diagnostic imaging apparatus for medical use; Medical imaging apparatus; Automated analyzers for body fluids [for medical use].

Abrégé

A microplate comprising: a plurality of wells arranged in a two-dimensional array, each of the wells comprising: a bottom surface, sidewalls extending from the bottom surface to form an open top; and at least two subwells in the bottom surface, the at least two subwells having sidewalls that extend below the bottom surface of the well, wherein each of the at least two subwells comprises a capture binding agent that is configured to bind to a target analyte, if present, in a sample. A sample is added to the well such that the sample fluidically contacts each of the at least two subwells such that a target analyte, if present, binds to the capture binding agent in one or more of the at least two subwells, wherein a labeled conjugate (e.g., an upconverting nanoparticle (UCNP) labeled conjugate) in the sample binds with the target analyte, if present. A label (e.g., UCNP) of the labeled conjugate is detected at one or more of the at least two subwells to thereby determine whether the target analyte is present in the sample.

Classes IPC  ?

• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques

Abrégé

A lateral flow test strip reader for reading an output of a lateral flow assay to determine a presence or absence of a target in a sample includes: a housing having a lateral flow test strip receptacle for receiving a lateral flow test strip therein, the lateral flow test strip receptacle defining a test region and a control region for a lateral flow test strip; a light source that generates an excitation light beam; at least one lens for optically expanding the excitation light beam in a direction across the test region and the control region such that the excitation light beam is configured to simultaneously impinge and excite both the test region and the control region; and an optical detector configured to simultaneously detect an image comprising emission signals from the test region and the control region, wherein the detected emission signals indicate a presence or absence of a target in the sample.

Classes IPC  ?

• G01N 33/76 - Gonadotropine chorionique humaine
• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• C12N 5/073 - Cellules ou tissus embryonnaires; Cellules fœtales ou tissus fœtaux

Abrégé

A lateral flow test strip reader for reading an output of a lateral flow assay to determine a presence or absence of a target in a sample includes: a housing having a lateral flow test strip receptacle for receiving a lateral flow test strip therein, the lateral flow test strip receptacle defining a test region and a control region for a lateral flow test strip; a light source that generates an excitation light beam; at least one lens for optically expanding the excitation light beam in a direction across the test region and the control region such that the excitation light beam is configured to simultaneously impinge and excite both the test region and the control region; and an optical detector configured to simultaneously detect an image comprising emission signals from the test region and the control region, wherein the detected emission signals indicate a presence or absence of a target in the sample.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• C12N 5/073 - Cellules ou tissus embryonnaires; Cellules fœtales ou tissus fœtaux
• G01N 21/01 - Dispositions ou appareils pour faciliter la recherche optique
• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
• G01N 33/76 - Gonadotropine chorionique humaine

Abrégé

A microplate comprising: a plurality of wells arranged in a two-dimensional array, each of the wells comprising: a bottom surface, sidewalls extending from the bottom surface to form an open top; and at least two subwells in the bottom surface, the at least two subwells having sidewalls that extend below the bottom surface of the well, wherein each of the at least two subwells comprises a capture binding agent that is configured to bind to a target analyte, if present, in a sample. A sample is added to the well such that the sample fluidically contacts each of the at least two subwells such that a target analyte, if present, binds to the capture binding agent in one or more of the at least two subwells, wherein a labeled conjugate (e.g., an upconverting nanoparticle (UCNP) labeled conjugate) in the sample binds with the target analyte, if present. A label (e.g., UCNP) of the labeled conjugate is detected at one or more of the at least two subwells to thereby determine whether the target analyte is present in the sample.

Classes IPC  ?

• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 21/01 - Dispositions ou appareils pour faciliter la recherche optique
• G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
• G01N 33/76 - Gonadotropine chorionique humaine

Abrégé

The present disclosure relates to a method, system, and kit for analyzing a biological sample that has been dried on a sample carrier, the method comprising: a) creating a combination within a vessel, the combination comprising the sample carrier, an elution solution, and a reaction solution, wherein the sample carrier has not been subjected to incubation prior to creating the combination; and b) incubating the combination within the vessel to elute the biological sample from the sample carrier and to perform qPCR on the biological sample.

Classes IPC  ?

• C12Q 1/6851 - Amplification quantitative

Produits et services

Diagnostic reagents and preparations, except for medical or veterinary use; diagnostic reagents for scientific or research use; reagents for research purposes; reagents for industrial purposes; reagents for use in analytical tests [other than for medical or veterinary purposes]; diagnostic preparations for scientific use; diagnostic preparations for scientific or research use other than for medical use; diagnostic reagents, other than for medical use for sale in kit form; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; reagents for use with analyzers [other than for medical or veterinary purposes]; chemical reagents for use with immunoassay analyzers, other than for medical or veterinary use; immunoassay reagents, other than for medical use; chemically treated test strips, other than for medical purposes; chemical paper for use with assays; lateral flow assay test strips, other than for medical or veterinary purposes; chemical testing kits comprised of lateral flow assay test strips and diagnostic reagents for scientific or research use. Diagnostic reagents for medical use; medical diagnostic reagents and assays for testing of body fluids; diagnostic preparations for medical or veterinary purposes; preparations for detecting genetic predispositions for medical purposes; reagents and media for medical and veterinary diagnostic purposes; reagents for medical use; reagents for use in diagnostic tests [for medical purposes]; reagents for use in diagnostic tests [for veterinary purposes]; reagents for use with analyzers [for medical purposes]; reagents for use with analyzers [for veterinary purposes]; immunoassay reagents for medical use; medical diagnostic test strips; lateral flow assay test strips for medical and veterinary diagnostic purposes; medical diagnostic kits comprised of lateral flow assay test strips and diagnostic reagents for medical use. Laboratory apparatus and instruments; diagnostic apparatus, not for medical purposes; laboratory instruments [other than for medical use]; testing apparatus not for medical purposes; testing apparatus for diagnostic purposes [other than medical]; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; laboratory instrument for the detection of pathogens and toxins in a biological sample for research use; imaging devices for scientific purposes; fluorescence analyzers; luminescence analyzers; nanoparticle size analyzers; optical readers; lateral flow readers for scientific purposes; computer software relating to the medical field; computer software for use in medical decision support systems; computer software for use in medical diagnosis and testing; computer software for medical and veterinary apparatus and instruments; computer software for laboratory apparatus and instruments. Medical and veterinary apparatus and instruments; analytical instruments for medical use; apparatus for use in medical analysis; apparatus for carrying-out diagnostic tests for medical purposes; instruments for use in medical analysis; diagnostic apparatus for medical purposes; diagnostic instruments for medical use; medical diagnostic apparatus for medical purposes; medical diagnostic instruments; testing instruments for medical diagnostic purposes; diagnostic testing apparatus for use in immunoassay procedures [medical]; diagnostic testing instruments for use in immunoassay procedure [medical]; diagnostic imaging apparatus for medical use; medical imaging apparatus; automated analyzers for body fluids [for medical use]; kits for testing for the presence of analytes in biological fluids, other fluids and other matrices, all for medical purposes; lateral flow readers for use in medical analysis and diagnostics. Providing temporary use of online non-downloadable software; installation, maintenance, updating and upgrading of computer software.

Produits et services

(1) Diagnostic reagents and preparations, except for medical or veterinary use; diagnostic reagents for scientific or research use; reagents for research purposes; reagents for industrial purposes; reagents for use in analytical tests [other than for medical or veterinary purposes]; diagnostic preparations for scientific use; diagnostic preparations for scientific or research use other than for medical use; diagnostic reagents, other than for medical use for sale in kit form; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; reagents for use with analyzers [other than for medical or veterinary purposes]; chemical reagents for use with immunoassay analyzers, other than for medical or veterinary use; immunoassay reagents, other than for medical use; chemically treated test strips, other than for medical purposes; chemical paper for use with assays; lateral flow assay test strips, other than for medical or veterinary purposes; chemical testing kits comprised of lateral flow assay test strips and diagnostic reagents for scientific or research use. (2) Diagnostic reagents for medical use; medical diagnostic reagents and assays for testing of body fluids; diagnostic preparations for medical or veterinary purposes; preparations for detecting genetic predispositions for medical purposes; reagents and media for medical and veterinary diagnostic purposes; reagents for medical use; reagents for use in diagnostic tests [for medical purposes]; reagents for use in diagnostic tests [for veterinary purposes]; reagents for use with analyzers [for medical purposes]; reagents for use with analyzers [for veterinary purposes]; immunoassay reagents for medical use; medical diagnostic test strips; lateral flow assay test strips for medical and veterinary diagnostic purposes; medical diagnostic kits comprised of lateral flow assay test strips and diagnostic reagents for medical use. (3) Laboratory apparatus and instruments; diagnostic apparatus, not for medical purposes; laboratory instruments [other than for medical use]; testing apparatus not for medical purposes; testing apparatus for diagnostic purposes [other than medical]; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; laboratory instrument for the detection of pathogens and toxins in a biological sample for research use; imaging devices for scientific purposes; fluorescence analyzers; luminescence analyzers; nanoparticle size analyzers; optical readers; lateral flow readers for scientific purposes; computer software relating to the medical field; computer software for use in medical decision support systems; computer software for use in medical diagnosis and testing; computer software for medical and veterinary apparatus and instruments; computer software for laboratory apparatus and instruments. (4) Medical and veterinary apparatus and instruments; analytical instruments for medical use; apparatus for use in medical analysis; apparatus for carrying-out diagnostic tests for medical purposes; instruments for use in medical analysis; diagnostic apparatus for medical purposes; diagnostic instruments for medical use; medical diagnostic apparatus for medical purposes; medical diagnostic instruments; testing instruments for medical diagnostic purposes; diagnostic testing apparatus for use in immunoassay procedures [medical]; diagnostic testing instruments for use in immunoassay procedure [medical]; diagnostic imaging apparatus for medical use; medical imaging apparatus; automated analyzers for body fluids [for medical use]; kits for testing for the presence of analytes in biological fluids, other fluids and other matrices, all for medical purposes; lateral flow readers for use in medical analysis and diagnostics. (1) Providing temporary use of online non-downloadable software; installation, maintenance, updating and upgrading of computer software.

Produits et services

Diagnostic reagents and preparations, except for medical or veterinary use; diagnostic reagents for scientific or research use; reagents for research purposes; chemical reagents for industrial purposes; chemical reagents for use in analytical tests other than for medical or veterinary purposes; diagnostic preparations for scientific use; diagnostic preparations for scientific or research use other than for medical use; diagnostic reagents, other than for medical use or veterinary use for sale in kit form; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; chemical reagents for use with analyzers other than for medical or veterinary purposes; chemical reagents for use with immunoassay analyzers, other than for medical or veterinary use; immunoassay reagents, other than for medical use or veterinary use; chemically treated test strips, other than for medical purposes, for testing blood, serum, saliva and urine; chemical test paper for use with assays; lateral flow assay test strips, other than for medical or veterinary purposes for testing blood, serum, saliva and urine; chemical testing kits comprised of lateral flow assay test strips and diagnostic reagents for scientific or research use for testing blood, serum, saliva and urine Diagnostic reagents for medical use; medical diagnostic reagents and assays for testing of body fluids; diagnostic preparations for medical or veterinary purposes; preparations for detecting genetic predispositions for medical purposes; reagents and media for medical and veterinary diagnostic purposes; reagents for medical use; reagents for use in diagnostic tests for medical purposes; reagents for use in diagnostic tests for veterinary purposes; reagents for use with analyzers for medical purposes; reagents for use with analyzers for veterinary purposes; immunoassay reagents for medical use; medical diagnostic test strips for blood, serum, saliva and urine analysis; lateral flow assay test strips for medical and veterinary diagnostic purposes for blood, serum, saliva and urine analysis; medical diagnostic kits comprised of lateral flow assay test strips and diagnostic reagents for medical use for blood, serum, saliva and urine analysis Laboratory apparatus and instruments, namely, research laboratory analyzers in the form of sample readers for use in fluorescence, luminescence and photometric assays; diagnostic apparatus, not for medical purposes, namely, diagnostic apparatus for measuring, testing and analyzing blood and other bodily fluids; laboratory instruments other than for medical use, namely, blood collection instruments for laboratory research use; testing apparatus not for medical purposes, namely, diagnostic apparatus for placental growth factor testing; testing apparatus for diagnostic purposes other than medical, namely, diagnostic apparatus for testing proteins in blood, serum, saliva and urine; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; laboratory instrument for the detection of pathogens and toxins in a biological sample for research use; imaging devices for scientific purposes, namely, photometric analyzers other than for medical use; x-ray fluorescence analyzers; luminescence analyzers, namely, photo electron spectroscopy analyzers, not for medical purposes; nanoparticle size analyzers; optical readers; lateral flow readers for scientific purposes; downloadable and recorded computer software relating to the medical field for medical imaging in the field of medical diagnostics; downloadable and recorded computer software for use in medical decision support systems for blood, serum, saliva and urine testing and analysis; downloadable and recorded computer software for use in medical diagnosis and testing for blood, serum, saliva and urine testing and analysis; downloadable and recorded computer software for medical and veterinary apparatus and instruments for blood, serum, saliva and urine testing and analysis; downloadable and recorded computer software for laboratory apparatus and instruments for blood, serum, saliva and urine testing and analysis Medical and veterinary apparatus and instruments for testing and analysis of blood, serum, saliva and urine; analytical instruments for medical use, namely, apparatus for blood, serum, saliva and urine analysis; apparatus for use in medical analysis, namely, apparatus for blood, serum, saliva and urine analysis; apparatus for carrying-out diagnostic tests for medical purposes, namely, medical diagnostic apparatus for placental growth factor testing; instruments for use in medical analysis, namely, blood collection medical instruments; diagnostic apparatus for medical purposes, namely, medical diagnostic apparatus for blood, serum, saliva and urine analysis; diagnostic instruments for medical use, namely, medical diagnostic instruments for blood, serum, saliva and urine analysis; medical diagnostic apparatus for medical purposes, namely, medical diagnostic apparatus for testing proteins in blood, serum, saliva and urine; medical diagnostic instruments for the analysis of body fluids; testing instruments for medical diagnostic purposes, namely, medical diagnostic apparatus for testing proteins in blood, serum, saliva and urine; medical diagnostic testing apparatus for use in immunoassay procedures; medical diagnostic testing instruments for use in immunoassay procedures; diagnostic imaging apparatus for medical use; medical imaging apparatus; automated analyzers for body fluids for medical use; kits for testing for the presence of analytes in biological fluids, other fluids and other matrices, all for medical purposes comprising sample pipettes, calibration cassettes, lateral flow cassettes and assay buffers; lateral flow readers for use in medical analysis and diagnostics Providing temporary use of online non-downloadable software for blood, serum, saliva and urine testing and analysis; installation, maintenance, updating and upgrading of computer software

Produits et services

Diagnostic reagents and preparations, except for medical or veterinary use; Diagnostic reagents for scientific or research use; Reagents for research purposes; Reagents for industrial purposes; Reagents for use in analytical tests [other than for medical or veterinary purposes]; Diagnostic preparations for scientific use; Diagnostic preparations for scientific or research use other than for medical use; Diagnostic reagents, other than for medical use for sale in kit form; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Reagents for use with analyzers [other than for medical or veterinary purposes]; Chemical reagents for use with immunoassay analyzers, other than for medical or veterinary use; Immunoassay reagents, other than for medical use; Chemically treated test strips, other than for medical purposes; Chemical paper for use with assays; Lateral flow assay test strips, other than for medical or veterinary purposes; Chemical testing kits comprised of lateral flow assay test strips and diagnostic reagents for scientific or research use. Diagnostic reagents for medical use; Medical diagnostic reagents and assays for testing of body fluids; Diagnostic preparations for medical or veterinary purposes; Preparations for detecting genetic predispositions for medical purposes; Reagents and media for medical and veterinary diagnostic purposes; Reagents for medical use; Reagents for use in diagnostic tests [for medical purposes]; Reagents for use in diagnostic tests [for veterinary purposes]; Reagents for use with analyzers [for medical purposes]; Reagents for use with analyzers [for veterinary purposes]; Immunoassay reagents for medical use; Medical diagnostic test strips; Lateral flow assay test strips for medical and veterinary diagnostic purposes; Medical diagnostic kits comprised of lateral flow assay test strips and diagnostic reagents for medical use. Laboratory apparatus and instruments; Diagnostic apparatus, not for medical purposes; Laboratory instruments [other than for medical use]; Testing apparatus not for medical purposes; Testing apparatus for diagnostic purposes [other than medical]; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Laboratory instrument for the detection of pathogens and toxins in a biological sample for research use; Imaging devices for scientific purposes; Fluorescence analyzers; Luminescence analyzers; Nanoparticle size analyzers; Optical readers; Lateral flow readers for scientific purposes; Computer software relating to the medical field; Computer software for use in medical decision support systems; Computer software for use in medical diagnosis and testing; Computer software for medical and veterinary apparatus and instruments; Computer software for laboratory apparatus and instruments. Medical and veterinary apparatus and instruments; Analytical instruments for medical use; Apparatus for use in medical analysis; Apparatus for carrying-out diagnostic tests for medical purposes; Instruments for use in medical analysis; Diagnostic apparatus for medical purposes; Diagnostic instruments for medical use; Medical diagnostic apparatus for medical purposes; Medical diagnostic instruments; Testing instruments for medical diagnostic purposes; Diagnostic testing apparatus for use in immunoassay procedures [medical]; Diagnostic testing instruments for use in immunoassay procedure [medical]; Diagnostic imaging apparatus for medical use; Medical imaging apparatus; Automated analyzers for body fluids [for medical use]; Kits for testing for the presence of analytes in biological fluids, other fluids and other matrices, all for medical purposes; Lateral flow readers for use in medical analysis and diagnostics. Providing temporary use of online non-downloadable software; Installation, maintenance, updating and upgrading of computer software.

Produits et services

Diagnostic reagents and preparations, except for medical or veterinary use; Diagnostic reagents for scientific or research use; Reagents for research purposes; Reagents for industrial purposes; Reagents for use in analytical tests [other than for medical or veterinary purposes]; Diagnostic preparations for scientific use; Diagnostic preparations for scientific or research use other than for medical use; Diagnostic reagents, other than for medical use for sale in kit form; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Reagents for use with analyzers [other than for medical or veterinary purposes]; Chemical reagents for use with immunoassay analyzers, other than for medical or veterinary use; Immunoassay reagents, other than for medical use; Chemically treated test strips, other than for medical purposes; Chemical paper for use with assays; Lateral flow assay test strips, other than for medical or veterinary purposes; Chemical testing kits comprised of lateral flow assay test strips and diagnostic reagents for scientific or research use. Diagnostic reagents for medical use; Medical diagnostic reagents and assays for testing of body fluids; Diagnostic preparations for medical or veterinary purposes; Preparations for detecting genetic predispositions for medical purposes; Reagents and media for medical and veterinary diagnostic purposes; Reagents for medical use; Reagents for use in diagnostic tests [for medical purposes]; Reagents for use in diagnostic tests [for veterinary purposes]; Reagents for use with analyzers [for medical purposes]; Reagents for use with analyzers [for veterinary purposes]; Immunoassay reagents for medical use; Medical diagnostic test strips; Lateral flow assay test strips for medical and veterinary diagnostic purposes; Medical diagnostic kits comprised of lateral flow assay test strips and diagnostic reagents for medical use. Laboratory apparatus and instruments; Diagnostic apparatus, not for medical purposes; Laboratory instruments [other than for medical use]; Testing apparatus not for medical purposes; Testing apparatus for diagnostic purposes [other than medical]; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Laboratory instrument for the detection of pathogens and toxins in a biological sample for research use; Imaging devices for scientific purposes; Fluorescence analyzers; Luminescence analyzers; Nanoparticle size analyzers; Optical readers; Lateral flow readers for scientific purposes; Computer software relating to the medical field; Computer software for use in medical decision support systems; Computer software for use in medical diagnosis and testing; Computer software for medical and veterinary apparatus and instruments; Computer software for laboratory apparatus and instruments. Medical and veterinary apparatus and instruments; Analytical instruments for medical use; Apparatus for use in medical analysis; Apparatus for carrying-out diagnostic tests for medical purposes; Instruments for use in medical analysis; Diagnostic apparatus for medical purposes; Diagnostic instruments for medical use; Medical diagnostic apparatus for medical purposes; Medical diagnostic instruments; Testing instruments for medical diagnostic purposes; Diagnostic testing apparatus for use in immunoassay procedures [medical]; Diagnostic testing instruments for use in immunoassay procedure [medical]; Diagnostic imaging apparatus for medical use; Medical imaging apparatus; Automated analyzers for body fluids [for medical use]; Kits for testing for the presence of analytes in biological fluids, other fluids and other matrices, all for medical purposes; Lateral flow readers for use in medical analysis and diagnostics. Providing temporary use of online non-downloadable software; Installation, maintenance, updating and upgrading of computer software.

Abrégé

The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNFR1, PIGF2, Activin A, uE3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A device for managing a sample to be analyzed comprises magnetizing equipment (302) for producing magnetic field capable of interacting, when the sample is moving to or located in a sample well, with magnetically amplifying material attached to the sample, where the magnetically amplifying material has relative magnetic permeability constant greater than one. With the aid of the magnetizing element the movement of the sample to the sample well and/or the position of the sample in the sample well can be monitored and/or controlled. The device can be, for example but not necessarily, an instrument for dispensing samples to sample wells or an optical measurement instrument.

Classes IPC  ?

• G01N 1/28 - Préparation d'échantillons pour l'analyse
• G01N 21/03 - Dispositions ou appareils pour faciliter la recherche optique - Détails de structure des cuvettes
• G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
• G01R 33/02 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques

Abrégé

A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Produits et services

Diagnostic apparatus for the detection of pathogens for laboratory or research use; electrophoresis apparatus not for medical purposes; medical laboratory research instruments for dna analysis; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; scientific instrumentation for measuring proteins; apparatus and instruments for electrophoresis and mass spectrometry.

Abrégé

A device for cutting off one or more sample regions from a sample carrier that contains impregnated sample material, e.g. blood, is described. The device includes: a cutting unit (103) for cutting off the one or more sample regions from the sample carrier, an optical imaging unit (101) for producing an electronic image of the sample carrier, and a processor (102) for controlling a display screen (108) to display the image (104) and one or more indicators (105, 105′) each expressing the location of one sample region to be cut off. Thus, an operator of the device is enabled to monitor, without direct visual communication to the sample carrier, what region or regions of the sample carrier is/are to be cut off. As no direct visual communication with the sample carrier is needed, the working ergonomics of the operator can be improved.

Classes IPC  ?

• B26D 5/00 - Dispositions pour manœuvrer et commander les machines ou les dispositifs de coupe, découpage, poinçonnage, perforation ou séparation autrement que par coupe
• G01N 1/28 - Préparation d'échantillons pour l'analyse

Produits et services

Diagnostic apparatus for the detection of pathogens for laboratory or research use; Electrophoresis apparatus not for medical purposes; Medical laboratory research instruments for DNA analysis; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Scientific instrumentation for measuring proteins; Apparatus and instruments for electrophoresis and mass spectrometry

Abrégé

A measurement device includes mechanical support elements (101-104) for supporting a sample well, other mechanical support elements (105-109) for supporting a measurement head (112) suitable for optical measurements, and a control system (111) configured to control the measurement head to carry out at least two optical measurements from at least two different measurement locations inside the sample well, where each measurement location is a center point of a capture range from which radiation is captured in the respective optical measurement. The final measurement result is formed from the results of the at least two optical measurements in accordance with a pre-determined rule. The use of the at least two optical measurements from different measurement locations reduces measurement variation in situations where the sample well (153) contains a piece (158) of sample carrier.

Classes IPC  ?

• G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
• G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G01N 1/28 - Préparation d'échantillons pour l'analyse
• G01N 21/47 - Dispersion, c. à d. réflexion diffuse
• G01D 18/00 - Test ou étalonnage des appareils ou des dispositions prévus dans les groupes
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

A dispenser device includes: a valve system, a dispensing head for dispensing liquid and connected with a transfer tube to the valve system, a dispensing pump connected to the valve system, a first inlet port for conducting rinse liquid to the valve system, and a second inlet port for conducting rinse gas to the valve system. The device includes control equipment for operating the valve system so that the flow via the transfer tube towards the dispensing head includes both the rinse liquid and the rinse gas. The rinse gas is capable of collecting gas bubbles formed on the inner walls of the transfer tube to larger amounts of gas. Thus, the rinse gas facilitates the removal of the gas bubbles with the aid of the rinse liquid.

Classes IPC  ?

• G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
• B01L 3/02 - Burettes; Pipettes
• G01F 11/02 - Appareils qu'il faut actionner de l'extérieur, adaptés à chaque opération répétée et identique, pour mesurer et séparer le volume prédéterminé d'un fluide ou d'un matériau solide fluent à partir d'une alimentation ou d'un récipient sans tenir compte avec chambres de mesure qui se dilatent ou se contractent au cours du mesurage
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• G01F 11/00 - Appareils qu'il faut actionner de l'extérieur, adaptés à chaque opération répétée et identique, pour mesurer et séparer le volume prédéterminé d'un fluide ou d'un matériau solide fluent à partir d'une alimentation ou d'un récipient sans tenir compte

Abrégé

The present description relates to a method for determining the risk of a pregnant woman with chronic hypertension developing early or late onset pre-eclampsia. The present description provides methods useful for determining risk that a pregnant individual with chronic hypertension will develop an early pre-eclampsia or late pre-eclampsia. Useful combination of biochemical markers including PlGF and sP-Selectin and related clinical population studies are described herein.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/74 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des hormones

Abrégé

The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNR1, P1GF2, Activin A, Ue3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet

Abrégé

A device for detecting whether a sample well (352) contains a sample is presented. The sample well contains one or more fluorescent substances needed for an optical analysis of the sample. The device includes a controller (312) configured to compute, on the basis of a luminescence, e.g. fluorescence, emission signal measured from the sample well, an indicator value indicative of a decay time of the measured fluorescence emission signal. The controller is configured to compare the indicator value to a reference value and to set, in accordance with the comparison, a detection result to express that the sample well contains the sample or that the sample well does not contain the sample.

Classes IPC  ?

• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

A device for managing a sample to be analyzed comprises magnetizing equipment (302) for producing magnetic field capable of interacting, when the sample is moving to or located in a sample well, with magnetically amplifying material attached to the sample, where the magnetically amplifying material has relative magnetic permeability constant greater than one. With the aid of the magnetizing element the movement of the sample to the sample well and/or the position of the sample in the sample well can be monitored and/or controlled. The device can be, for example but not necessarily, an instrument for dispensing samples to sample wells or an optical measurement instrument.

Classes IPC  ?

• G01N 1/28 - Préparation d'échantillons pour l'analyse
• G01N 21/03 - Dispositions ou appareils pour faciliter la recherche optique - Détails de structure des cuvettes
• G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
• G01R 33/02 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques

Abrégé

An instrument for processing sample carrier cards (116-118) is described. Each sample carrier card contains impregnated sample material, e.g. blood. The instrument comprises actuators (108-110) capable of doing actions related to the sample carrier cards when the sample carrier cards are located on operating areas of the actuators. The actions may comprise e.g. optical imaging, cutting off sample pieces from a sample carrier card, and reading machine-readable information from a sample carrier card. The instrument comprises a rotatably supported carousel element (102) for carrying the sample carrier cards so that separate ones of the sample carrier cards are on separate ones of the operating areas and the sample carrier cards are movable between the operating areas by rotating the carousel element. Thus, the actions can be carried out in parallel and therefore the sample carrier cards can be processed in a pipelined manner enabling a higher processing rate.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
• G01N 1/28 - Préparation d'échantillons pour l'analyse
• G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
• B01L 9/00 - Dispositifs de support; Dispositifs de serrage

Abrégé

The invention relates to a method and apparatus for detecting elution of a sample from a sample substrate to incubation buffer contained in a sample well while the sample substrate is still within the well. The method comprises measuring light absorption of the contents of the sample well at a predefined wavelength or wavelength range, and determining, based on the absorption measurement, the degree of elution of the sample. According to the invention, a wavelength or wavelength range is used which is absorbed by at least one elutable component of the sample but transmitted by the sample substrate. The invention provides a reliable way of determining the degree of elution of blood samples in neonatal screening, for example.

Classes IPC  ?

• G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• G01N 21/31 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique

Abrégé

A dispenser device comprises: a valve system (101), a dispensing head (102) for dispensing liquid and connected with a transfer tube (103) to the valve system, a dispensing pump (104) connected to the valve system, a first inlet port (105) for conducting rinse liquid to the valve system, and a second inlet port (106) for con- ducting rinse gas to the valve system. The device comprises control equipment (107) for operating the valve system so that the flow via the transfer tube towards the dispensing head comprises both the rinse liquid and the rinse gas. The rinse gas is capable of collecting gas bubbles formed on the inner walls of the transfer tube to larger amounts of gas. Thus, the rinse gas facilitates the removal of the gas bubbles with the aid of the rinse liquid.

Classes IPC  ?

• B01L 3/02 - Burettes; Pipettes
• B01L 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
• G01F 15/12 - Dispositions pour le nettoyage; Filtres
• G01F 11/02 - Appareils qu'il faut actionner de l'extérieur, adaptés à chaque opération répétée et identique, pour mesurer et séparer le volume prédéterminé d'un fluide ou d'un matériau solide fluent à partir d'une alimentation ou d'un récipient sans tenir compte avec chambres de mesure qui se dilatent ou se contractent au cours du mesurage
• G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection

Abrégé

A dispenser device comprises: a valve system (101), a dispensing head (102) for dispensing liquid and connected with a transfer tube (103) to the valve system, a dispensing pump (104) connected to the valve system, a first inlet port (105) for conducting rinse liquid to the valve system, and a second inlet port (106) for con- ducting rinse gas to the valve system. The device comprises control equipment (107) for operating the valve system so that the flow via the transfer tube towards the dispensing head comprises both the rinse liquid and the rinse gas. The rinse gas is capable of collecting gas bubbles formed on the inner walls of the transfer tube to larger amounts of gas. Thus, the rinse gas facilitates the removal of the gas bubbles with the aid of the rinse liquid.

Classes IPC  ?

• B01L 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
• B01L 3/02 - Burettes; Pipettes
• G01F 11/02 - Appareils qu'il faut actionner de l'extérieur, adaptés à chaque opération répétée et identique, pour mesurer et séparer le volume prédéterminé d'un fluide ou d'un matériau solide fluent à partir d'une alimentation ou d'un récipient sans tenir compte avec chambres de mesure qui se dilatent ou se contractent au cours du mesurage
• G01F 15/12 - Dispositions pour le nettoyage; Filtres
• G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection

Abrégé

The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNR1, PlGF2, Activin A, Ue3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present description relates to a method for determining the risk of a pregnant woman with chronic hypertension developing early or late onset pre-eclampsia. The present description provides methods useful for determining risk that a pregnant individual with chronic hypertension will develop an early pre-eclampsia or late pre-eclampsia. Useful combination of biochemical markers including PlGF and sP-Selectin and related clinical population studies are described herein.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A method for cross-talk correction of intensities measured on mutually separate detection wavelength bands is presented. Each detection wavelength band relates to one of analyte-specific probe-populations contained by a sample to be analyzed. Each probe-population is capable of emitting a first signal component and a second signal component whose spectra have maxima at different wavelengths and at least the first signal component is dependent on presence of analyte detectable with that probe-population. Cross-talk corrected intensities are computed on the basis of a) the intensities measured on the detection wavelength bands, b) a value indicative of intensity occurring on an auxiliary wavelength band outside the detection wavelength bands and at least partially caused by the second signal components, and c) pre-determined cross-talk parameters. For example in con-junction with FRET-based assays, the dependency of a background signal on the percentage of hybridized probes can be taken into account in the cross-talk correction.

Classes IPC  ?

• H04Q 11/00 - Dispositifs de sélection pour systèmes multiplex
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
• G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtainedfrom the pregnant individualto determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of Amylin, 17β-Estradiol, and Lipocalin-2, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsiveto the identifying, determining a prediction corresponding to a relative risk of the pregnantindividual having or developing GDM.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A device for detecting whether a sample well (352) contains a sample is presented. The sample well contains one or more fluorescent substances needed for an optical analysis of the sample. The device comprises a controller (312) configured to compute, on the basis of a luminescence, e.g. fluorescence, emission signal measured from the sample well (352), an indicator value indicative of a decay time of the measured fluorescence emission signal. The controller (312) is configured to compare the indicator value to a reference value and to set, in accordance with the comparison, a detection result to express that the sample well (352) contains the sample or that the sample well (352) does not contain the sample.

Classes IPC  ?

• G01N 21/62 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

A device for detecting whether a sample well (352) contains a sample is presented. The sample well contains one or more fluorescent substances needed for an optical analysis of the sample. The device comprises a controller (312) configured to compute, on the basis of a luminescence, e.g. fluorescence, emission signal measured from the sample well (352), an indicator value indicative of a decay time of the measured fluorescence emission signal. The controller (312) is configured to compare the indicator value to a reference value and to set, in accordance with the comparison, a detection result to express that the sample well (352) contains the sample or that the sample well (352) does not contain the sample.

Classes IPC  ?

• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

A device for managing a sample to be analyzed comprises magnetizing equipment (302) for producing magnetic field capable of interacting, when the sample is moving to or located in a sample well, with magnetically amplifying material attached to the sample, where the magnetically amplifying material has relative magnetic permeability constant greater than one. With the aid of the magnetizing element the movement of the sample to the sample well and/or the position of the sample in the sample well can be monitored and/or controlled. The device can be, for example but not necessarily, an instrument for dispensing samples to sample wells or an optical measurement instrument.

Classes IPC  ?

• G01N 1/28 - Préparation d'échantillons pour l'analyse
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet

Abrégé

A switch device for producing one or more electrical signals in response to mechanical force includes a body-part (101) and one or more electric transducers (102-105) connected to the body-part and arranged to produce the one or more electrical signals in response to mechanical force directed to the body-part. The body-part includes a cavity (106), and a wall constituting the bottom of the cavity is capable of being bent by mechanical force directed to the wall from the opposite side with respect to the cavity. The one or more electric transducers are located in the cavity and arranged to produce the one or more electrical signals when the bottom of the cavity is bent. The switch device can be built, for example, into a working plane of an electrical instrument so that a plate constituting the working plane constitutes also the body-part of the switch device.

Classes IPC  ?

• H01L 41/113 - Eléments piézo-électriques ou électrostrictifs à entrée mécanique et sortie électrique
• H03K 17/96 - Commutateurs à effleurement

Abrégé

A method for cross-talk correction of intensities measured on mutually separate detection wavelength bands is presented. Each detection wavelength band relates to one of analyte-specific probe-populations contained by a sample to be analyzed. Each probe-population is capable of emitting a first signal component and a second signal component whose spectra have maxima at different wavelengths and at least the first signal component is dependent on presence of analyte detectable with that probe-population. Cross-talk corrected intensities are computed on the basis of a) the intensities measured on the detection wavelength bands, b) a value indicative of intensity occurring on an auxiliary wavelength band outside the detection wavelength bands and at least partially caused by the second signal components, and c) pre-determined cross-talk parameters. For example in con- junction with FRET-based assays, the dependency of a background signal on the percentage of hybridized probes can be taken into account in the cross-talk correction.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
• G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A method for predicting risk of pre-eclampsia in a pregnant individual includes measuring one or more biochemical markers including an RBP4 biochemical marker in a blood sample obtained from the pregnant individual to determine one or more biomarker levels including an RBP4 biomarker level, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A measurement device includes mechanical support elements (101-104) for supporting a sample well, other mechanical support elements (105-109) for supporting a measurement head (112) suitable for optical measurements, and a control system (111) configured to control the measurement head to carry out at least two optical measurements from at least two different measurement locations inside the sample well, where each measurement location is a center point of a capture range from which radiation is captured in the respective optical measurement. The final measurement result is formed from the results of the at least two optical measurements in accordance with a pre-determined rule. The use of the at least two optical measurements from different measurement locations reduces measurement variation in situations where the sample well (153) contains a piece (158) of sample carrier.

Classes IPC  ?

• G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
• G01N 21/64 - Fluorescence; Phosphorescence
• G01D 18/00 - Test ou étalonnage des appareils ou des dispositions prévus dans les groupes

Abrégé

The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual is carrying a fetus having a chromosomal abnormality based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers.

Classes IPC  ?

• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
• G01N 31/00 - Recherche ou analyse des matériaux non biologiques par l'emploi des procédés chimiques spécifiés dans les sous-groupes; Appareils spécialement adaptés à de tels procédés
• G06Q 50/24 - Gestion de dossiers médicaux (traitement de données médicales ou biologiques à des fins scientifiques G06F 19/00)
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)

Abrégé

Described herein are methods and apparatus for storing and transferring patient information related to biological sample testing using biological sample cards and short range communications. In certain embodiments, the disclosed technology provides for the localized data transfer with biological sample cards equipped with a transmission and storage device that is capable of storing data such as patient information so that errors associated with manually entering handwritten patient information are reduced. The transmission and storage device may include a radio frequency identification (RFID) tag/chip such as a near field communication (NFC) tag/chip.

Classes IPC  ?

• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)

Abrégé

A method for diminishing variation between and/or within individual sheets of filter papers which are suitable for collecting samples of biological material, e.g. blood, is described. The method includes at least one of the following: subjecting the sheets of filter paper to gaseous substance containing at least 30 grams water per cubic meter and/or wetting the sheets of filter paper with water and subsequently drying the sheets of filter paper. According to tests, the above-described treatment significantly reduces the undesirable variation between results analyzed from sheets of filter paper and impregnated with same biological material for test purposes.

Classes IPC  ?

• G01N 31/00 - Recherche ou analyse des matériaux non biologiques par l'emploi des procédés chimiques spécifiés dans les sous-groupes; Appareils spécialement adaptés à de tels procédés
• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
• F26B 1/00 - Traitement préliminaire d'un matériau solide ou d'objets pour faciliter le séchage
• G01N 1/28 - Préparation d'échantillons pour l'analyse
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur

Abrégé

The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual is carrying a fetus having a chromosomal abnormality based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers.

Classes IPC  ?

• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
• G01N 31/00 - Recherche ou analyse des matériaux non biologiques par l'emploi des procédés chimiques spécifiés dans les sous-groupes; Appareils spécialement adaptés à de tels procédés

Abrégé

An apparatus and a system for filtering a liquid sample in a sample well (310) by transferring the liquid out of the sample well (310) through a filter member (320) situated at a bottom part of the sample well (310). The apparatus and the system include a syringe (100), and a seal member (200) arranged around a nozzle (140) of the syringe (100) in such a way that the syringe (100) is adjustable in connection with an upper part of the sample well (310) in a substantially airtight manner. A method for filtering a liquid sample and use of the system for filtering eluted blood are also disclosed.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B01L 3/02 - Burettes; Pipettes

Abrégé

A switch device for producing one or more electrical signals in response to mechanical force comprises a body-part (101) and one or more electric transducers (102-105) connected to the body-part and arranged to produce the one or more electrical signals in response to mechanical force directed to the body-part. The body-part comprises a cavity (106), and a wall constituting the bottom of the cavity is capable of being bent by mechanical force directed to the wall from the opposite side with respect to the cavity. The one or more electric transducers are located in the cavity and arranged to produce the one or more electrical signals when the bottom of the cavity is bent. The switch device can be built, for example, into a working plane of an electrical instrument so that a plate constituting the working plane constitutes also the body-part of the switch device.

Classes IPC  ?

• H03K 17/96 - Commutateurs à effleurement

Abrégé

A measurement device comprises mechanical support elements (101-104) for supporting a sample well, other mechanical support elements (105-109) for supporting a measurement head (112) suitable for optical measurements, and a control system (111) configured to control the measurement head to carry out at least two optical measurements from at least two different measurement locations inside the sample well, where each measurement location is a center point of a capture range from which radiation is captured in the respective optical measurement. The final measurement result is formed from the results of the at least two optical measurements in accordance with a pre-determined rule. The use of the at least two optical measurements from different measurement locations reduces measurement variation in situations where the sample well (153) contains a piece (158) of sample carrier.

Classes IPC  ?

• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

A measurement device comprises mechanical support elements (101-104) for supporting a sample well, other mechanical support elements (105-109) for supporting a measurement head (112) suitable for optical measurements, and a control system (111) configured to control the measurement head to carry out at least two optical measurements from at least two different measurement locations inside the sample well, where each measurement location is a center point of a capture range from which radiation is captured in the respective optical measurement. The final measurement result is formed from the results of the at least two optical measurements in accordance with a pre-determined rule. The use of the at least two optical measurements from different measurement locations reduces measurement variation in situations where the sample well (153) contains a piece (158) of sample carrier.

Classes IPC  ?

• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

An optical measurement instrument includes: an excitation light source (120) arranged to produce an excitation beam for at least one of samples to be measured and a detector (132) arranged to detect an emission beam emitted by one of the samples to be measured and to produce a detection signal responsive to the detected emission beam. The optical measurement instrument further includes an arrangement for controlling temperature of the samples to be measured. The arrangement includes: one or more temperature sensors (176) for producing one or more temperature signals responsive to temperature of a measurement chamber (170) of the optical measurement instrument, one or more heating resistors (171-175) arranged to warm the measurement chamber, and a controller (177) arranged to control electrical power supplied to the heating resistors on the basis of the one or more temperature signals.

Classes IPC  ?

• G01N 21/01 - Dispositions ou appareils pour faciliter la recherche optique
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 21/03 - Dispositions ou appareils pour faciliter la recherche optique - Détails de structure des cuvettes

Abrégé

A method for diminishing variation between and/or within individual sheets of filter papers which are suitable for collecting samples of biological material, e.g. blood, is described. The method comprises at least one of the following: subjecting the sheets of filter paper to gaseous substance containing at least 30 grams water per cubic meter and/or wetting the sheets of filter paper with water and subsequently drying the sheets of filter paper. According to tests, the above-described treatment significantly reduces the undesirable variation between results analyzed from sheets of filter paper and impregnated with same biological material for test purposes.

Classes IPC  ?

• G01N 1/28 - Préparation d'échantillons pour l'analyse
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur

Abrégé

A method for diminishing variation between and/or within individual sheets of filter papers which are suitable for collecting samples of biological material, e.g. blood, is described. The method comprises at least one of the following: subjecting the sheets of filter paper to gaseous substance containing at least 30 grams water per cubic meter and/or wetting the sheets of filter paper with water and subsequently drying the sheets of filter paper. According to tests, the above-described treatment significantly reduces the undesirable variation between results analyzed from sheets of filter paper and impregnated with same biological material for test purposes.

Classes IPC  ?

• G01N 1/28 - Préparation d'échantillons pour l'analyse
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur

Abrégé

A device for cutting off one or more sample regions from a sample carrier that contains impregnated sample material, e.g. blood, is described. The device comprises: a cutting unit (101) for cutting off the one or more sample regions from the sample carrier, a support element (102) for supporting a sample well element (117) so that a sample well of the sample well element is able to receive each sample region cut off from the sample carrier, and an ionizer (103) for ionizing gas, e.g. air, that is, when the sample well element has been placed to the support element, in contact with the sample well element so as to discharge possible static electricity from the sample well element with the aid of the ionized gas. Therefore, the adverse effect of static electricity that can be present in the sample well element can be reduced or eliminated.

Classes IPC  ?

• G01N 1/04 - Dispositifs pour prélever des échantillons à l'état solide, p.ex. par coupe à l'outil

Abrégé

A device for cutting off one or more sample regions from a sample carrier that contains impregnated sample material, e.g. blood, is described. The device comprises: a cutting unit (103) for cutting off the one or more sample regions from the sample carrier, an optical imaging unit (101 ) for producing an electronic image of the sample carrier, and a processor (102) for controlling a display screen (108) to display the image (104) and one or more indicators (105, 105') each expressing the location of one sample region to be cut off. Thus, an operator of the device is enabled to monitor, without direct visual communication to the sample carrier, what region or regions of the sample carrier is/are to be cut off. As no direct visual communication with the sample carrier is needed, the working ergonomics of the operator can be improved.

Classes IPC  ?

• G01N 1/28 - Préparation d'échantillons pour l'analyse

Abrégé

The present description relates to a method for determining the risk of a pregnant woman developing a hypertensive disorder, more specifically gestational hyper-tension or late onset preeclampsia. The present description provides methods useful for determining risk that a pregnant individual will develop a hypertensive disorder or condition of pregnancy, such as gestational hypertension, early preeclampsia, late preeclampsia and related disorders. Several useful combinations of biochemical markers and related clinical population studies are described herein. Additionally, it is proposed herein that certain sets of biochemical markers can be used to determine risk of multiple hypertensive disorders in a single screen. The biochemical markers are PlGF, Activin A and optionally P-Selectin.

Classes IPC  ?

• G01N 31/00 - Recherche ou analyse des matériaux non biologiques par l'emploi des procédés chimiques spécifiés dans les sous-groupes; Appareils spécialement adaptés à de tels procédés
• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
• G01N 33/74 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des hormones

Abrégé

A lens and reflector unit for optical measurements includes first and second convex surface sections of the lens and reflector unit. Both have their respective central normal lines. A first flat surface section has a normal direction that divides the angle between the central normal lines into equal halves. A third convex surface section has a third central normal line, and the fourth convex surface section has a fourth central normal line. A second flat surface section has a normal direction that divides the angle between the third and fourth central normal lines into to equal halves.

Classes IPC  ?

• G01N 21/64 - Fluorescence; Phosphorescence
• G02B 17/00 - Systèmes avec surfaces réfléchissantes, avec ou sans éléments de réfraction
• G02B 17/08 - Systèmes catadioptriques

Abrégé

The present technology discloses biotinidase assay, biotinidase substrates (I) and a kit wherein the biotinidase substrate includes a label molecule separated from the biotin carbamoyl group by a linker X longer than about 4 Å but shorter than about 27 Å.

Classes IPC  ?

• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une hydrolase
• C07D 403/02 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles
• C07D 235/00 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, condensés avec d'autres cycles
• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 de la classification périodique

Abrégé

An optical measurement instrument includes one or more temperature sensors (122) arranged to measure sample well specific temperatures from sample wells (111-117) arranged to store samples (103-109) to be optically measured. A processing device (121) of the optical measurement instrument is arranged to correct, using a pre-determined mathematical rule, measurement results obtained by the optical measurements on the basis of the measured sample well specific temperatures. Hence, the adverse effect caused by temperature differences between different samples on the accuracy of the temperature correction of the measurement results is mitigated.

Classes IPC  ?

• G01N 25/20 - Recherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant la production de quantités de chaleur, c. à d. la calorimétrie, p.ex. en mesurant la chaleur spécifique, en mesurant la conductivité thermique
• G01J 5/08 - Dispositions optiques
• G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

An optical measurement instrument comprises operational modules (101-107) that are interconnected via a digital communication network (110). Each operational module comprises a transceiver (111-117) connected to the digital communication network and arranged to support a pre-determined digital communication protocol employed in the digital communication network. Those operational modules that include a detector further comprise an analog-to-digital converter (118) for converting a detected signal into a digital form and a digital circuitry (119) for providing digital information based on the detected signal with address data related to a particular operational module to which the digital information is to be delivered via the digital communication network. As information is transferred between operational modules via the digital communication network using the pre-determined digital communication protocol, the operational modules can be tested independently of each other using a test bench system arranged to support the pre-determined digital communication protocol.

Classes IPC  ?

• H04B 10/00 - Systèmes de transmission utilisant des ondes électromagnétiques autres que les ondes hertziennes, p.ex. les infrarouges, la lumière visible ou ultraviolette, ou utilisant des radiations corpusculaires, p.ex. les communications quantiques

Abrégé

A body module of an optical measurement instrument includes: a reception device (201) for receiving samples, a first plate (202), a second plate (203) substantially parallel with the first plate and movably supported relative to the first plate in a direction perpendicular to the first and second plates, and walls extending from outer edges of the first plate to outer edges of the second plate. The reception device is located in a measurement chamber constituted by the walls and the first and second plates. At least the second plate includes a fastening interface provided with an aperture. The fastening interface is suitable for an optical module to be mounted to the second plate. The measuring chamber provides protection against undesired stray light from surroundings. The movability of the second plate allows adjustment of a distance between a sample and an optical module mounted to the second plate.

Classes IPC  ?

• G01J 1/58 - Photométrie, p.ex. posemètres photographiques en utilisant une luminescence produite par la lumière
• G21H 3/02 - Dispositions pour la conversion directe de l'énergie de rayonnement des sources radioactives en des formes d'énergie autres que l'énergie électrique, p.ex. en lumière dans lesquelles le matériau est excité à la luminescence par le rayonnement
• G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide

Abrégé

Certain aspects and examples are directed to systems and methods for assessing risk of chromosomal disorders. Certain embodiments are directed to systems and methods that use nuchal translucency values from both twins to provide a fetus specific risk of a chromosomal disorder in at least one fetus of the twins fetuses.

Classes IPC  ?

• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
• A61B 5/107 - Mesure de dimensions corporelles, p.ex. la taille du corps entier ou de parties de celui-ci
• A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements

Produits et services

Chemicals for use in science and industry; diagnostic preparations for scientific or research use; [ diagnostic preparations for clinical or medical laboratory use; ] diagnostic reagents for scientific and research purposes; [ diagnostic reagents for clinical or medical laboratory use; ] assays and reagents for use in genetic research; diagnostic kits consisting primarily of polymerase chain reaction (PCR) mixes for detection of aneuploidies in chromosomes for scientific or research use; chemical analysis kit for use in DNA analysis, not for medical or veterinary use; chemical test kits for cell assays for laboratory or research use Chemical reagents for medical or veterinary purposes; [ diagnostic preparations for medical or veterinary purposes; diagnostic reagents for medical purposes; ] preparations for detecting genetic predispositions for medical purposes; [ medical diagnostic reagents and assays for testing bodily fluids; diagnostic kits consisting primarily of polymerase chain reaction (PCR) mixes for detection of aneuploidies in chromosomes for medical use; diagnostic reagents, assays and kits for medical use, namely, for detecting, diagnosing, treating and monitoring of genetic disorders; ] chemical test kits for cell assays for medical and veterinary use

Abrégé

The invention relates to method and apparatus for determining from a sample carrier containing an impregnated biological sample a sample region to be removed. The method comprises optically imaging the sample carrier into a digital matrix form, where the optical brightness of each physical location of the sample is represented by elements of the matrix; determining a first threshold value at least partly on the basis of the elements of the matrix; and calculating coordinates corresponding to the sample region to be removed from the sample carrier, the coordinates being such that the sample region contains only areas of the sample carrier having an optical brightness lower than or equal to said first threshold value. The invention allows for more efficient use of samples in sample cards.

Classes IPC  ?

• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet

Produits et services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; Unprocessed artificial resins, unprocessed plastics; Manures; Fire extinguishing compositions; Tempering and soldering preparations; Chemical substances for preserving foodstuffs; Tanning substances; Adhesives used in industry. Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; Apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; Apparatus for recording, transmission or reproduction of sound or images; Magnetic data carriers, recording discs; Automatic vending machines and mechanisms for coin-operated apparatus; Cash registers, calculating machines, data processing equipment and computers; Fire-extinguishing apparatus; Computer peripheral devices; Computer programmes [programs], recorded; Computer programs [downloadable software]; Computer software, recorded; Electronic publications [downloadable]; Interfaces for computers; Monitors [computer programs]; Furniture especially made for laboratories; Microscope slides (Containers for -).

Abrégé

An optical measurement instrument comprises: an excitation light source (120) arranged to produce an excitation beam for at least one of samples to be measured and a detector (132) arranged to detect an emission beam emitted by one of the samples to be measured and to produce a detection signal responsive to the detected emission beam. The optical measurement instrument further comprises an arrangement for controlling temperature of the samples to be measured. The arrangement comprises: one or more temperature sensors (176) for producing one or more temperature signals responsive to temperature of a measurement chamber (170) of the optical measurement instrument, one or more heating resistors (171-175) arranged to warm the measurement chamber, and a controller (177) arranged to control electrical power supplied to the heating resistors on the basis of the one or more temperature signals.

Classes IPC  ?

• G05D 23/19 - Commande de la température caractérisée par l'utilisation de moyens électriques
• G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

The present invention relates to an integrated method of nucleic acid analysis, and more particularly to a simplified sample pre-treatment, which renders the method more easily automated, where the sample is provided on or applied onto a solid matrix and the subsequent amplification and detection steps are performed in one single, sealed reaction vial without removing the matrix.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques

Produits et services

Chemicals for use in science and industry; DNA preparations for scientific or research use; DNA preparations for clinical or medical laboratory use; reagents and nucleic acids for scientific and research purposes; assays and reagents for use in genetic research; chemical preparations for use in industry and science used for DNA amplification; DNA amplification kits for enabling research using DNA and comprising DNA polymerase, buffers, and reagents for scientific and research use; chemical solutions and preparations consisting of pre-mixed reactants and reagents for scientific and research use in connection with amplification, analysis or labeling of nucleic acid; chemical analysis kit for use in DNA analysis, not for medical or veterinary use; chemical test kits for cell assays for laboratory or research use. Chemical reagents for medical or veterinary purposes; DNA preparations for medical or veterinary purposes; DNA reagents and nucleic acids for medical purposes; DNA amplification kits for enabling research using DNA and comprising DNA polymerase, buffers, and reagents for medical, medical diagnostic or veterinary use; chemical solutions and preparations consisting of pre-mixed reactants and reagents for medical, medical diagnostic or veterinary use in connection with amplification, analysis or labeling of nucleic acid; chemical analysis kit for use in DNA analysis for medical or veterinary use; chemical test kits for cell assays for medical and veterinary use.

Produits et services

Chemicals for use in science and industry; diagnostic preparations for scientific or research use; diagnostic preparations for clinical or medical laboratory use; diagnostic reagents for scientific and research purposes; diagnostic reagents for clinical or medical laboratory use; assays and reagents for use in genetic research; diagnostic kits consisting primarily of polymerase chain reaction (PCR) mixes for detection of aneuploidies in chromosomes for scientific or research use; chemical analysis kit for use in DNA analysis, not for medical or veterinary use; chemical test kits for cell assays for laboratory or research use. Chemical reagents for medical or veterinary purposes; diagnostic preparations for medical or veterinary purposes; diagnostic reagents for medical purposes; preparations for detecting genetic predispositions for medical purposes; medical diagnostic reagents and assays for testing bodily fluids; diagnostic kits consisting primarily of polymerase chain reaction (PCR) mixes for detection of aneuploidies in chromosomes for medical use; diagnostic reagents, assays and kits for medical use, namely, for detecting, diagnosing, treating and monitoring of genetic disorders; chemical test kits for cell assays for medical and veterinary use; none of the aforesaid including diagnostic imaging agents for in-vivo use.

Abrégé

The invention relates to a method and apparatus for detecting elution of a sample from a sample substrate to incubation buffer contained in a sample well while the sample substrate is still within the well. The method comprises measuring light absorption of the contents of the sample well at a predefined wavelength or wavelength range, and determining, based on the absorption measurement, the degree of elution of the sample. According to the invention, a wavelength or wavelength range is used which is absorbed by at least one elutable component of the sample but transmitted by the sample substrate. The invention provides a reliable way of determining the degree of elution of blood samples in neonatal screening, for example.

Classes IPC  ?

• G01N 21/31 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique
• G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Produits et services

Computer software for patient data management; computer software for medical applications, namely, software for recording, checking, distributing, calculating, analyzing and reporting medical images and medical information; computer software for use in medical diagnosis and testing; computer software for calculation and assessment of health risks and risks for genetic disorders.

Abrégé

The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual is carrying a fetus having a chromosomal abnormality based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers.

Classes IPC  ?

• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
• G01N 31/00 - Recherche ou analyse des matériaux non biologiques par l'emploi des procédés chimiques spécifiés dans les sous-groupes; Appareils spécialement adaptés à de tels procédés

Abrégé

The present description relates to a method for determining the risk of a pregnant woman developing a hypertensive disorder, more specifically gestational hyper-tension or late onset preeclampsia. The present description provides methods useful for determining risk that a pregnant individual will develop a hypertensive disorder or condition of pregnancy, such as gestational hypertension, early preec-lampsia, late preeclampsia and related disorders. Several useful combinations of biochemical markers and related clinical population studies are described herein. Additionally, it is proposed herein that certain sets of biochemical markers can be used to determine risk of multiple hypertensive disorders in a single screen. The biochemical markers are PlGF, Activin A and optionally P-Selectin.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/74 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des hormones

Abrégé

The present description relates to a method for determining the risk of a pregnant woman developing a hypertensive disorder, more specifically gestational hyper-tension or late onset preeclampsia. The present description provides methods useful for determining risk that a pregnant individual will develop a hypertensive disorder or condition of pregnancy, such as gestational hypertension, early preec-lampsia, late preeclampsia and related disorders. Several useful combinations of biochemical markers and related clinical population studies are described herein. Additionally, it is proposed herein that certain sets of biochemical markers can be used to determine risk of multiple hypertensive disorders in a single screen. The biochemical markers are P1GF, Activin A and optionally P-Selectin.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/74 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des hormones

Abrégé

The present invention provides an immunoassay, wherein the analyte is adsorbed to an underivatized hydrophobic sample surface. The assay is suitable for screening of haemoglobinopathies.

Classes IPC  ?

• G01N 33/72 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir les pigments du sang, p.ex. l'hémoglobine, la bilirubine

Abrégé

An apparatus for optically analyzing samples contained in sample sites of a sample holder, the apparatus has a first light source and at least one second light source, a monochromator having an input to which first light source is optically connected or connectable and an output for monochromatized light, light guiding portion for guiding light originating from the first and from the at least one second light sources to the sample sites, and a detector for detecting light from the sample sites. A light relay having a first input optically connected to the output of the monochromator, at least one second input optically connected or connectable to a second light source such that the light from the second light source by-passes the monochromator, and a first output for guiding light from selected input of the light relay to the sample sites. Based on the apparatus and light relay a versatile sample analyzer can be achieved in a cost-effective manner.

Classes IPC  ?

• G01N 21/64 - Fluorescence; Phosphorescence
• G01J 3/10 - Aménagements de sources lumineuses spécialement adaptées à la spectrométrie ou à la colorimétrie
• G01J 3/44 - Spectrométrie Raman; Spectrométrie par diffusion
• G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G01J 3/42 - Spectrométrie d'absorption; Spectrométrie à double faisceau; Spectrométrie par scintillement; Spectrométrie par réflexion
• G01J 3/12 - Production du spectre; Monochromateurs
• G02B 6/42 - Couplage de guides de lumière avec des éléments opto-électroniques
• G01J 3/02 - Spectrométrie; Spectrophotométrie; Monochromateurs; Mesure de la couleur - Parties constitutives

Abrégé

The present technology discloses biotinidase assay, biotinidase substrates (I) and a kit wherein the biotinidase substrate includes a label molecule separated from the biotin carbamoyl group by a linker X longer than about 4.ANG. but shorter than about 27.ANG..

Classes IPC  ?

• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une hydrolase
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur

Abrégé

The present technology discloses biotinidase assay, biotinidase substrates (I) and a kit wherein the biotinidase substrate includes a label molecule separated from the biotin carbamoyl group by a linker X longer than about 4Å but shorter than about 27Å.

Classes IPC  ?

• C12Q 1/10 - Entérobactéries
• C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase

Produits et services

Software for processing and analyzing images; life science software, namely, microarray image analysis software.

Abrégé

An optical measurement instrument,which is equipped with transportation protection, includes a body structure (201), a mechanical support element(202) for supporting an optical interface, a moveably supported receptable element (211) for receiving a sample plate and located between the mechanical support element and the body structure, and a detachable transportation protection element (212-215) arranged to mechanically restrict movements of the receptable element and the mechanical support element. The transportation protection element is arranged to be pressed between the mechanical support element (202) and the body structure (201).Hence, for the transportation protection,there is no need to usee.g. a bolt that may be more laborious to install and remove than the transportation protection element to be pressed between the mechanical support element (202) and the body structure (201).

Classes IPC  ?

• G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
• G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• B65D 85/38 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour objets particulièrement sensibles aux dommages par chocs ou compression pour appareils optiques de mesure, de calcul ou de commande délicats
• B65D 81/05 - Réceptacles, éléments d'emballage ou paquets pour contenus présentant des problèmes particuliers de stockage ou de transport ou adaptés pour servir à d'autres fins que l'emballage après avoir été vidés de leur contenu spécialement adaptés pour protéger leur contenu des dommages mécaniques maintenant le contenu en position éloignée des parois de l'emballage ou des autres pièces du contenu

Abrégé

Instrumentation and a method for efficient and reliable assaying and measuring samples. The teachings include an automated self-contained instrument, wherein the samples are located on wells of sample plates, and the instrument includes a plurality of units for processing or storing sample plates. The instrument may includes at least one dispensing unit for dispensing reagents or other assay components to the sample wells, at least two units for simultaneously processing or storing a plurality of sample plates, at least one unit for removing substance from the sample wells, and one or several measurement units for optically measuring samples in at least two measurement modes. Further, the instrument includes a manipulator for moving the sample plates in three orthogonal directions or combinations thereof and for rotating the sample plates in relation to a vertical axis for transferring the sample plates to the units.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet

Abrégé

This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.

Classes IPC  ?

• A61K 51/00 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo
• A61M 36/14 - Pansements radioactifs

Abrégé

An optical measurement instrument comprises operational modules (101 -107) that are interconnected via a digital communication network (110). Each operational module comprises a transceiver (111 -117) connected to the digital communication network and arranged to support a pre-determined digital communication protocol employed in the digital communication network. Those operational modules that include a detector further comprise an analog-to-digital converter (118) for converting a detected signal into a digital form and a digital circuitry (119) for providing digital information based on the detected signal with address data related to a particular operational module to which the digital information is to be delivered via the digital communication network. As information is transferred between operational modules via the digital communication network using the pre-determined digital communication protocol, the operational modules can be tested independently of each other using a test bench system arranged to support the pre-determined digital communication protocol.

Classes IPC  ?

• H04J 3/06 - Dispositions de synchronisation
• H04L 12/40 - Réseaux à ligne bus

Abrégé

An optical measurement instrument comprises a measurement head (101) and mechanical support elements (102, 103) arranged to support a sample plate (106). The measurement head is moved towards the sample plate and, after the measurement head has touched the sample plate, the measurement head is moved backwards away from the sample plate so as to provide a desired distance between the measurement head and the sample plate. A sensor device (112, 113) is attached to the mechanical support elements and arranged detect a mechanical effect occurring in the mechanical support elements due to force directed by the measurement head to the sample plate. Hence, the situation in which the measurement head touches the sample plate can be detected without a need to provide the measurement head with a force sensor. This is advantageous because the measurement head can be a changeable module of the optical measurement instrument.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
• G01N 21/13 - Transport des cuvettes ou des échantillons solides vers ou à partir de l'emplacement de recherche

Abrégé

A lens and reflector unit for optical measurements comprises first and second convex surface sections of said lens and reflector unit. Both have their respective central normal lines. A first flat surface section has a normal direction that divides the angle between the central normal lines into equal halves. A third convex surface section has a third central normal line,and the fourth convex surface section has a fourth central normal line. A second flat surface section has a normal direction that divides the angle between the third and fourth central normal lines into to equal halves.

Classes IPC  ?

• G02B 17/00 - Systèmes avec surfaces réfléchissantes, avec ou sans éléments de réfraction
• G02B 17/08 - Systèmes catadioptriques
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

A body module of an optical measurement instrument comprises: a reception de- vice (201) for receiving samples, a first plate (202), a second plate (203) substantially parallel with the first plate and movably supported relative to the first plate in a direction perpendicular to the first and second plates, and walls extending from outer edges of the first plate to outer edges of the second plate. The reception de- vice is located in a measurement chamber constituted by the walls and the first and second plates. At least the second plate comprises a fastening interface provided with an aperture. The fastening interface is suitable for an optical module to be mounted to the second plate. The measuring chamber provides protection against undesired stray light from surroundings. The movability of the second plate allows adjustment of a distance between a sample and an optical module mounted to the second plate.

Classes IPC  ?

• G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
• G01N 21/13 - Transport des cuvettes ou des échantillons solides vers ou à partir de l'emplacement de recherche

Abrégé

An optical measurement instrument according to the invention comprises one or more temperature sensors(122) arranged to measure sample well specific temperatures from sample wells(111-117) arranged to store samples (103-109) to be optically measured. A processing device (121) of the optical measurement instrument is arranged to correct, using a predetermined mathematical rule, measurement results obtained by the optical measurements on the basis of the measured sample well specific temperatures. Hence, the adverse effect caused by temperature differences between different samples on the accuracy of the temperature correction of the measurement results is mitigated.

Classes IPC  ?

• G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

A body module of an optical measurement instrument comprises: a reception de- vice (201) for receiving samples, a first plate (202), a second plate (203) substantially parallel with the first plate and movably supported relative to the first plate in a direction perpendicular to the first and second plates, and walls extending from outer edges of the first plate to outer edges of the second plate. The reception de- vice is located in a measurement chamber constituted by the walls and the first and second plates. At least the second plate comprises a fastening interface provided with an aperture. The fastening interface is suitable for an optical module to be mounted to the second plate. The measuring chamber provides protection against undesired stray light from surroundings. The movability of the second plate allows adjustment of a distance between a sample and an optical module mounted to the second plate.

Classes IPC  ?

• G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
• G01N 21/13 - Transport des cuvettes ou des échantillons solides vers ou à partir de l'emplacement de recherche

Abrégé

An optical measurement instrument comprises a measurement head (101 ) and mechanical support elements (102, 103) arranged to support a sample plate (106). The measurement head is moved towards the sample plate and, after the measurement head has touched the sample plate, the measurement head is moved backwards away from the sample plate so as to provide a desired distance between the measurement head and the sample plate. A sensor device (112, 113) is attached to the mechanical support elements and arranged detect a mechanical effect occurring in the mechanical support elements due to force directed by the measurement head to the sample plate. Hence, the situation in which the measurement head touches the sample plate can be detected without a need to provide the measurement head with a force sensor. This is advantageous because the measurement head can be a changeable module of the optical measurement instrument.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
• G01N 21/13 - Transport des cuvettes ou des échantillons solides vers ou à partir de l'emplacement de recherche

Abrégé

An optical measurement instrument comprises operational modules (101 -107) that are interconnected via a digital communication network (110). Each operational module comprises a transceiver (111 -117) connected to the digital communication network and arranged to support a pre-determined digital communication protocol employed in the digital communication network. Those operational modules that include a detector further comprise an analog-to-digital converter (118) for converting a detected signal into a digital form and a digital circuitry (119) for providing digital information based on the detected signal with address data related to a particular operational module to which the digital information is to be delivered via the digital communication network. As information is transferred between operational modules via the digital communication network using the pre-determined digital communication protocol, the operational modules can be tested independently of each other using a test bench system arranged to support the pre-determined digital communication protocol.

Classes IPC  ?

• H04J 3/06 - Dispositions de synchronisation
• H04L 12/40 - Réseaux à ligne bus

Produits et services

Chemical preparations for scientific purposes; chemical reagents for nonmedical purposes; chemical substances and preparations for analyses in laboratories; biochemical catalysts; biological preparations for scientific use in chemical assays

Abrégé

The present invention relates to a method for determining the risk of a pregnant woman developing pre-eclampsia. The method comprises i) determining the level of one or more biochemical markers in a sample obtained from a pregnant woman, and ii) comparing the level of the at least one biochemical marker in the sample with the level of the same biochemical marker in a control sample. A difference in the level of the biochemical marker in the sample relative to the control sample is indicative of an increased risk of developing pre-eclampsia. The isoform biochemical markers are preferably PlGF-2 and PlGF-3. The present invention relates also to a method for determining whether a pregnant woman has pre-eclampsia and as well as a kit for assessing the risk or presence of pre-eclampsia. In addition, the invention relates also to a computer program used in these determinations.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides