Provided are non-exogenous nucleic acid-modified specific killer T cells, a preparation method therefor, and use thereof. The present invention pertains to the technical field of biological medicines. The preparation method for the specific killer T cells comprises the following steps: co-culturing CD3 +T cells and target cells, and simultaneously supplementing the co-culture with co-stimulatory activation factor CD28 ligands, wherein T cells with a cell diameter of 9.5-14.5 μm are specifically activated killer T cells and can be obtained and purified by means of flow cytometry sorting. The specifically activated killer T cells avoid various potential risks caused by exogenous nucleic acid introduction required for existing engineered specific killer T cell technologies, such as CAR-T and TCR-T. In addition, obtaining specific killer T cells from blood results in a much larger number of cells than obtaining specific killer T cells from tumor-infiltrating lymphocytes does and is convenient and efficient. The specific killer T cells can play an important role in the field of tumor cell therapy.
A method for C(sp2)-H bond deuteration in a benzene ring, comprising the following step: in a solvent and under phenol, alkali, and visible light conditions, subjecting a substance A to a deuteration reaction with a deuterium source to obtain a substance B. The photocatalytic benzene ring deuteration method is easy to operate and has wide application prospects.
C07D 209/00 - Composés hétérocycliques contenant des cycles à cinq chaînons condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle
3.
Primers and Probes and Reagent Kit for Synchronous Detection of CymMV, ORSV, and CymRSV, and Applications Thereof
FLOWER RESEARCH INSTITUTE OF YUNNAN ACADEMY OF AGRICULTURAL SCIENCES (Chine)
YUNNAN UNIVERSITY (Chine)
Inventeur(s)
Wang, Lihua
Sun, Aiqing
Wu, Xuewei
Qu, Suping
Zhang, Yiping
Yang, Xiumei
Su, Yan
Xu, Feng
Zhang, Lifang
Abrégé
A set of primers and probes for simultaneous detection of Cymbidium mosaic virus (CymMV), Odontoglossum ringspot virus (ORSV), and Cymbidium ringspot virus (CymRSV) and a method for detecting CymMV, ORSV, and CymRSV, along with a method for their detection, are disclosed. The method involves designing multiplex real-time quantitative PCR detection primers and probes for CymMV, ORSV, and CymRSV and applying these primers and probes to the real-time quantitative PCR simultaneous detection of CymMV, ORSV, and CymRSV. It allows for faster detection of CymMV, ORSV, and CymRSV, taking only one-third of the time compared to uniplex real-time quantitative PCR technology, thereby reducing testing costs by approximately ⅓ to ½ for each sample. The primers and probes are highly specific and sensitive, with a sensitivity as low as 1 to 10 copies. It provides an efficient and feasible detection method for early detection and prevention of CymMV, ORSV, and CymRSV.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
Provided is use of a steroid Taccoside A in preparing a tumor immunotherapy drug. The steroid Taccoside A can regulate T lymphocytes of the human immune system to effectively kill various types of tumor cells, including various non-solid tumor cells and solid tumor cells, and the cell viability results show that the survival rates of different types of tumor cells are 10% or below. The steroid Taccoside A can further show the same effective tumor immune killing effect on T lymphocytes from different blood type sources. Moreover, the steroid Taccoside A is a low-toxicity, highly effective tumor immunotherapy molecule that is applicable to a wide range of people and has killing effects on various types of tumor cells.
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
The present invention provides an environmentally friendly gold leaching method for gold ore containing carbon, sulfur and arsenic, and relates to the technical field of the metallurgical industry. The present invention utilizes fine grinding to open sediment with gold ore containing carbon, sulfur and arsenic, thus facilitating gold leaching; gold enrichment is achieved through jet pulse flotation, thus reducing the amount of ore processed; then an oxidation reaction is used to convert arsenic to arsenate and sulfur to sulfate, carbon passivation is performed and fine gold is exposed; then, a precipitation reaction is used to convert arsenic to scorodite, preventing the future dissolution of the arsenic; sulfate and carbonate are converted to calcium sulfate and calcium carbonate, the calcium carbonate is removed, and caustic soda is regenerated and reused; the present invention utilizes a cyanide-free gold leaching agent for leaching gold from a gold ore from which carbon, sulfur and arsenic have been removed, using an environmentally friendly agent not containing toxic cyanide and not harming the environment. The environmentally friendly gold leaching method of the present invention is carried out at normal temperature and normal pressure, is approximately neutral (a pH value of 6-8), and is suitable for widespread use.
The present disclosure provides an ultrafast Doppler ultrasound method for estimating a blood flow velocity through repetitive compounding of multi-angle plane waves. The method includes: controlling an ultrasonic transducer to cyclically transmit plane waves (101) according to a sequence of deflection angles of {0, −β, β, −β}; receiving echo signals (102) of the plane waves reflected by an area to be scanned; searching for three consecutive frames of signals with deflection angles in a sequence of {0, −β, β} and {β, −β, 0} in the echo signals to obtain multiple frame groups (103); compounding the three consecutive frames of signals of each frame group to obtain a compounded radio frequency (RF) signal (105); calculating a blood flow velocity (106) according to the compounded RF signal; and performing color coding on the blood flow velocity to generate a two-dimensional (2D) blood flow velocity image (107).
The present invention belongs to the technical field of photoelectric materials, and particularly relates to an organic room-temperature electrophosphorescent material, and a preparation method therefor and an organic electroluminescent diode thereof. The organic room-temperature electrophosphorescent material provided in the present invention has the characteristic structure of a fused arylamine electron donor D and an electron acceptor A, wherein the fused arylamine electron donor D has a structure of formula II-1 or II-2, and the fused arylamine electron donor provides molecular rigidity to inhibit the non-radiative attenuation of triplet-state excitons; X regulates and controls the intramolecular charge transfer while enhancing the spin-orbit coupling effect; A, serving as an electron acceptor, receives electrons provided by D; and finally, an effective room-temperature phosphorescence is obtained in an amorphous state.
C07D 265/38 - Oxazines-1, 4Oxazines-1, 4 hydrogénées condensés avec des carbocycles condensés en [b, e] avec deux cycles à six chaînons
C07D 279/22 - Thiazines-1, 4Thiazines-1, 4 hydrogénées condensés avec des carbocycles ou avec des systèmes carbocycliques condensés en [b, e] avec deux cycles à six chaînons avec des atomes de carbone liés directement à l'atome d'azote du cycle
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 513/22 - Composés hétérocycliques contenant dans le système condensé au moins un hétérocycle comportant des atomes d'azote et de soufre comme uniques hétéro-atomes du cycle, non prévus dans les groupes , ou dans lesquels le système condensé contient au moins quatre hétérocycles
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
C07F 9/6578 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle comportant des atomes de phosphore, avec ou sans atomes d'azote, d'oxygène, de soufre, de sélénium ou de tellure, comme hétéro-atomes du cycle comportant des atomes de phosphore et de soufre, avec ou sans atomes d'oxygène, comme hétéro-atomes du cycle
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
8.
METHOD FOR PROPAGATING SPOROPHYTE RECESSIVE NUCLEAR MALE STERILE
Provided is a method for propagating sporophyte recessive nuclear male sterile. The steps are as follows: transferring in a chain manner a sporophyte male fertile gene Y, a down-regulating expression element Xi of an endogenous gametophyte male fertile gene, a herbicide A resistance gene AR, a down-regulating element Bi of a herbicide B resistance gene, and an anthocyanin gene C or a down-regulating element Ci thereof to sterile mutants of the sporophyte fertile gene Y, and pollinating sterile plants with positive plants to propagate a sporophyte nuclear sterile line. The method is universal and applicable to all plants, and can obtain a sporophyte nuclear sterile line having a sterile plant rate of 100%, reduce the cost of separating sterile lines and maintainer lines, perform purity identification in an early, intuitive, fast, accurate and economic manner, and improve the purities of sterile lines of unqualified purities in an early, quick, economic and thorough manner for continued seed production; and related regulating elements can all select to be endogenous nucleic acid fragments.
A01H 1/02 - Méthodes ou appareils d'hybridationPollinisation artificielle
A01G 7/06 - Traitement des arbres ou des plantes en cours de croissance, p. ex. pour prévenir la décomposition du bois, pour teinter les fleurs ou le bois, pour prolonger la vie des plantes
C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
Provided are a rice pollen tube growth-related gene OsPTD1 (Pollen Tube Development) and an application. A protein encoded by the gene is an amino acid sequence represented by SEQ ID NO. 1, or a protein which has the same function as an OsPTD1 protein and is obtained by substituting, deleting, or adding at least one amino acid. The nucleotide sequence of a protein composed of the amino acid sequence represented by SEQ ID NO. 1 is represented by SEQ ID NO. 2. The OsPTD1 gene encodes ascorbic acid oxidase and is an essential gene for normal growth of a pollen tube; abnormality in functions of the gene may cause the pollen tube to rupture prematurely, thus insemination cannot be completed, and gametophytic male sterility is generated. The gene can be used for preparing gametophytic male sterility, and plays an important role in preventing transgenes from drifting with pollen, and genic male sterility of reproductive sporophytes.
C12N 15/29 - Gènes codant pour des protéines végétales, p. ex. thaumatine
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
A01H 6/46 - Gramineae ou Poaceae, p. ex. ivraie, riz, blé ou maïs
10.
ULTRASONIC DOPPLER BLOOD FLOW IMAGING METHOD AND SYSTEM
Disclosed are an ultrasonic Doppler blood flow imaging method and system. The imaging method comprises: acquiring a blood flow speed measuring interest region and the number of transmitting sub-apertures (101); determining, according to the number of transmitting sub-apertures, the inclination angle of a plane wave in each transmitting sub-aperture (102); determining, according to the inclination angle, an array element excitation delay time in each transmitting sub-aperture (103); controlling, according to the array element excitation delay time, all the transmitting sub-apertures to synchronously transmit plane waves, and receiving echo signals by using a full aperture (104); generating a radio frequency signal sequence according to the echo signals (105); extracting blood flow Doppler signals of the blood flow speed measuring interest region according to the radio frequency signal sequence (106); determining a blood flow speed according to the blood flow Doppler signals (107); and generating a Doppler blood flow image of the blood flow speed measuring interest region according to the blood flow speed (108). By means of the imaging method and system, the largest pulse repetition frequency can be realized, and motion artifacts introduced by radio frequency signal composition in ultra-fast ultrasonic Doppler blood flow imaging can also be suppressed.
A carotid pulse wave velocity estimation method and system. The method comprises: acquiring pulse waves of N lines of sound beam positions on a carotid artery to obtain N lines of pulse waves (S1); determining a first line of a pulse wave among the N lines of pulse waves as a reference pulse wave, and determining multiple reference template segments of the reference pulse wave; each reference template segment corresponds to one reference point position parameter and one length parameter (S2); determining a pulse wave variance sum corresponding to each reference template segment; the pulse wave variance sum is the sum of the smallest sum of variances; the sum of the smallest sum of variances is obtained by a reference template segment tracking an upshoot section of an nth line of the pulse wave from the wave trough to the wave crest; n∈[2,N] (S3); determining a reference template segment corresponding to the smallest pulse wave variance sum as an optimal template segment (S4); determining the reference point position parameter and length parameter corresponding to the optimal template segment as optimal parameters (S5); and estimating carotid pulse wave velocity from the optimal parameters (S6). The carotid pulse wave velocity estimation method and system can improve the estimation accuracy of pulse wave velocity.
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
A61B 5/0285 - Mesure de la vitesse de propagation de l'onde pulsatile
12.
ECOLOGICAL INTELLIGENT INDOOR THREE-DIMENSIONAL PLANT WALL AND CULTIVATION METHOD USING SAME
The present invention relates to an ecological intelligent indoor three-dimensional plant wall and a cultivation method using same. The ecological intelligent indoor three-dimensional plant wall comprises a planting module, a drip irrigation module, a light supplementing module, and an intelligent control module. The planting module comprises a planting board, vertical side boards, triangular nonwoven fabric planting bags, sphagnum, soilless culture media, and various plants. The drip irrigation module comprises an automatic water supply and fish breeding pool, a water pump having a filtering device, and a drip irrigation zone. The light supplementing module comprises spotlight rails and long-arm spotlights. The intelligent control module comprises an intelligent socket and an Internet network. These modules are combined to achieve the ecological intelligent indoor three-dimensional plant wall. The cultivation method using the ecological intelligent indoor three-dimensional plant wall can achieve not only a free plant-arrangement design and long-term stable growth of the plants, but also long-term stable growth of bred fishes.
This disclosure relates to pharmaceutical chemistry, and more particularly to a metalloporphyrin compound, and a preparation and application thereof. The metalloporphyrin compound is shown in formula (I), or an optical isomer, a pharmaceutically-acceptable salt or a solvate thereof, and can specifically recognize the HIV RNA and effectively inhibit HIV reverse transcriptase. This disclosure also provides uses of the compound in the preparation of a reagent for selectively recognizing HIV TAR RNA and a HIV reverse transcriptase inhibitor.
A method for ultrafast ultrasonic Doppler blood flow estimation by multi-angle plane wave repeated combination. The method comprises: controlling an ultrasonic transducer to circularly emit plane waves with deflection angles being {0, -beta, beta, -beta} in sequence (101); receiving echo signals of plane waves reflected by an area to be scanned (102); searching three frames of continuous signals of which the deflection angles are sequentially {0, -beta, beta} and the deflection angles are sequentially {beta, -beta, 0} in the echo signals so as to obtain a plurality of frame groups (103); superposing three frames of continuous signals in each frame group so as to obtain a combined radio frequency signal (105); calculating a blood flow velocity according to the combined radio frequency signal (106); and performing color coding on the blood flow velocity so as to generate a two-dimensional blood flow velocity image (107). In coherent combination, the last radio frequency echo signal is repeatedly used for next combination; and compared with a conventional coherent combination technology in which all radio frequency echo signals are only combined once, the method improves the pulse repetition frequency by 50%, so that the maximum blood flow velocity detectable range of the ultrafast ultrasonic Doppler technology is improved.
Kunming Institute of Zoology, Chinese Academy of Sciences (Chine)
Inventeur(s)
He, Yanping
Zhang, Hongbin
Zheng, Yongtang
Zhang, Yufang
Tang, Chengrun
Ding, Wei
Yang, Liumeng
Li, Yiming
Abrégé
Disclosed is a DACOs-type NNRTIs amino acid ester derivative, a preparation method thereof, a pharmaceutical composition, and an application thereof. The structure of the DACOs-type NNRTIs amino acid ester derivative is represented by formula (I). The DACOs-type NNRTIs amino acid ester derivative represented by formula (I) can be used as HIV-1 inhibitors and for the preparation of a drug for treating and/or preventing immunodeficiency viruses.
C07D 239/56 - Un atome d'oxygène et un atome de soufre
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
16.
Pyrimidinone-containing compound, preparation method thereof, pharmaceutical composition and application thereof
Kunming Institute of Zoology, Chinese Academy of Sciences (Chine)
Inventeur(s)
He, Yanping
Zhang, Hongbin
Zheng, Yongtang
Wu, Yumeng
Tang, Chengrun
Rui, Ruomei
Yang, Liumeng
Wang, Jiangyuan
Abrégé
Disclosed is a pyrimidinone-containing compound represented by formula I, a preparation method thereof, a pharmaceutical composition, and an application thereof. The pyrimidinone-containing compound of the present disclosure can be used as HIV-1 inhibitor and can be also used in the treatment of human immunodeficiency virus infection.
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 403/14 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having an oxadiazole-oxadiazolone structure (e.g., oxadiazole-phenyl-oxadiazolone compounds, oxadiazole-pyridine-oxadiazolone compounds, oxadiazole-indole-oxadiazolone compounds, oxadiazole-quinoline-oxadiazolone compounds, oxadiazole-pyrrole-oxadiazolone compounds, and oxadiazole-vinyl-oxadiazolone compounds), and their use as therapeutics for the treatment of cancer and other diseases.
C07D 413/10 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles aromatiques
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
18.
Saponin compound targeting PD-1 and application thereof
East China University Of Science And Technology (Chine)
Yunnan University (Chine)
Shanghai Institute of Materia Medica, Chinese Academy of Sciences (Chine)
Inventeur(s)
Li, Honglin
Xiao, Weilie
Zhu, Lili
Quan, Lina
Li, Qiao
Diao, Yanyan
Zhao, Zhenjiang
Jiang, Hualiang
Abrégé
Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease.
A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine liés à un système carbocyclique condensé, p. ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
A skid mounted device for upper-spreading internal diffusion vertical plug flow photocatalytic wastewater treatment includes internal diffusion vertical plug flow photocatalytic reaction tank groups and a skid base. The internal diffusion vertical plug flow photocatalytic reaction tank groups are arranged on the skid base. The internal diffusion vertical plug flow photocatalytic reaction tank groups are connected to each other in series, in parallel, or in series-parallel. Each internal diffusion vertical plug flow photocatalytic reaction tank group consists of two or more photocatalytic reaction tanks connected in series, in parallel, or in series-parallel. The wastewater pipes connected to the photocatalytic reaction tanks in each internal diffusion vertical plug flow photocatalytic reaction tank group are mounted above the photocatalytic reaction tanks.
A method for synthesizing 4-(Hydroxymethyl)benzoic acid using P-xylene (PX) as a raw material, including: dissolving PX in an organic solvent to undergo an oxidation reaction with an oxidizing agent under an action of an M-MOF catalyst; and after the oxidation reaction, performing a post-treatment to obtain the 4-(Hydroxymethyl)benzoic acid; wherein, the metal element M in the M-MOF catalyst is Fe, Cu, Cr, Mn, Cu/Fe, Cu/Cr, Cu/Mn, Fe/Mn, Cr/Fe or Cr/Mn. The by-product produced in the reaction process is little, the yield is high, and the separation is convenient. The acid-base neutralization is not required in the reaction process, reducing pollution. A one-step reaction is employed which has mild reaction conditions, short reaction time, low pollution and is convenient for industrialized mass production; and the obtained 4-(Hydroxymethyl)benzoic acid can be used for preparing medicines and liquid crystal materials having wide applications.
C07C 51/285 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par oxydation avec des composés peroxydés
B01J 31/16 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination
C07C 65/01 - Composés comportant des groupes carboxyle liés à des atomes de carbone de cycles aromatiques à six chaînons et contenant l'un des groupes OH, O-métal, —CHO, cétone, éther, des groupes , des groupes ou des groupes contenant des groupes hydroxyle ou O-métal
21.
Layered metal oxide field effect material and its application
2/V·s, and overcomes the problem that the carrier mobility of a conventional metal oxide field effect material is low, it is required to fabricate the metal oxide field effect material into a crystal phase structure with a relatively high cost, and even that a substrate thereof with a crystal phase structure is required.
H01L 51/52 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés pour l'émission de lumière, p.ex. diodes émettrices de lumière organiques (OLED) ou dispositifs émetteurs de lumière à base de polymères (PLED) - Détails des dispositifs
H01L 51/05 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés au redressement, à l'amplification, à la génération d'oscillations ou à la commutation et ayant au moins une barrière de potentiel ou une barrière de surface; Condensateurs ou résistances à l'état solide, ayant au moins une barrière de potentiel ou une barrière de surface
H01L 27/32 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des composants qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux avec des composants spécialement adaptés pour l'émission de lumière, p.ex. panneaux d'affichage plats utilisant des diodes émettrices de lumière organiques
H01L 51/00 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives
H01L 51/10 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés au redressement, à l'amplification, à la génération d'oscillations ou à la commutation et ayant au moins une barrière de potentiel ou une barrière de surface; Condensateurs ou résistances à l'état solide, ayant au moins une barrière de potentiel ou une barrière de surface - Détails des dispositifs
H01L 51/50 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés pour l'émission de lumière, p.ex. diodes émettrices de lumière organiques (OLED) ou dispositifs émetteurs de lumière à base de polymères (PLED)
A layered metal oxide field effect electrode includes multiple metal strips and layered metal oxide films. The band gap width of the first thin metal oxide film material is less than 3 eV; the band gap width of the second thin metal oxide film material is greater than 3 eV; the band gap width of the third thin metal oxide film material is less than 3 eV; the difference between the band gap width of the second thin metal oxide film material and the band gap width of the first thin metal oxide film material is greater than 1 eV; the difference between the band gap width of the second thin metal oxide film material and the band gap width of the third thin metal oxide film material is greater than 1 eV; and the thicknesses of the first thin metal oxide film, the second thin metal oxide film, and the third thin metal oxide film are each smaller than or equal to 10 nm. The layered metal oxide field effect electrode has the advantages of high light transmittance and a good field conduction performance.
H01L 29/08 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices avec des régions semi-conductrices connectées à une électrode transportant le courant à redresser, amplifier ou commuter, cette électrode faisant partie d'un dispositif à semi-conducteur qui comporte trois électrodes ou plus
H01L 51/52 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés pour l'émission de lumière, p.ex. diodes émettrices de lumière organiques (OLED) ou dispositifs émetteurs de lumière à base de polymères (PLED) - Détails des dispositifs
H01L 51/00 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives
23.
METHOD FOR PREPARING ELECTROCHEMICAL SENSOR FOR NON-CODING RNA AND USE THEREOF
344, respectively; after confirming that the materials are successfully constructed by means of material characterization, the target is electrochemically detected using screen-printed electrodes with toluidine blue and other substances as electrical signal substances. The electrochemical sensor prepared by this method can achieve the detection of the expression quantity of different lengths of transcripts of the non-coding region 3'UTR produced by alternative cleavage and polyadenylation (APA).
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
A method for preparing a layered metal oxide field effect material includes depositing a first metal oxide, a core-layer metal, and a second metal oxide sequentially on the substrate by vacuum vapor deposition, the first metal oxide and the core-layer metal undergoing a redox reaction to form a first surface layer and a core-layer precursor on the substrate, and the core-layer precursor and the second metal oxide undergoing a redox reaction to form a core layer and a second surface layer; and the band gap of the metal oxide in the core layer is ≥3 eV, the band gaps of the metal oxide in the first surface layer and the second surface layer are independently ≤3 eV, and the difference between the band gap of the metal oxide in the core layer and the band gap of the metal oxide in the first surface layer is ≥1 eV. The present preparation method has advantages of simple operation, a low production cost, a good film forming property, and the high carrier mobility of the product.
H01L 29/10 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices avec des régions semi-conductrices connectées à une électrode ne transportant pas le courant à redresser, amplifier ou commuter, cette électrode faisant partie d'un dispositif à semi-conducteur qui comporte trois électrodes ou plus
H01L 51/52 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés pour l'émission de lumière, p.ex. diodes émettrices de lumière organiques (OLED) ou dispositifs émetteurs de lumière à base de polymères (PLED) - Détails des dispositifs
H01L 51/05 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés au redressement, à l'amplification, à la génération d'oscillations ou à la commutation et ayant au moins une barrière de potentiel ou une barrière de surface; Condensateurs ou résistances à l'état solide, ayant au moins une barrière de potentiel ou une barrière de surface
H01L 27/32 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des composants qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux avec des composants spécialement adaptés pour l'émission de lumière, p.ex. panneaux d'affichage plats utilisant des diodes émettrices de lumière organiques
H01L 51/10 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés au redressement, à l'amplification, à la génération d'oscillations ou à la commutation et ayant au moins une barrière de potentiel ou une barrière de surface; Condensateurs ou résistances à l'état solide, ayant au moins une barrière de potentiel ou une barrière de surface - Détails des dispositifs
H01L 51/56 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives
H01L 51/50 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés pour l'émission de lumière, p.ex. diodes émettrices de lumière organiques (OLED) ou dispositifs émetteurs de lumière à base de polymères (PLED)
H01L 51/00 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives
KUNMING INSTITUTE OF BOTANY, CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Zhang, Hongbin
Wu, Mingjiang
Li, Yan
He, Yanping
Chen, Jingbo
Yang, Xiaodong
Chen, Wen
Gong, Yaxiao
Abrégé
The present invention discloses a gibberellin-like compound, a preparation method therefor, a pharmaceutical composition, uses and an intermediate thereof, wherein the gibberellin-like compound shown in formula (I) has relatively good in-vitro antitumor and cytotoxic activity, and has particularly remarkable in-vitro cytotoxic activity against breast cancer cells or colon cancer cells. (I)
C07C 49/747 - Composés non saturés comportant un groupe cétone faisant partie d'un cycle contenant des groupes hydroxyle contenant des cycles aromatiques à six chaînons
C07C 247/10 - Composés contenant des groupes azido avec des groupes azido liés à des atomes de carbone acycliques d'un squelette carboné étant non saturé et contenant des cycles
A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
26.
2-THIOMETHYLPYRAZOLOPYRIMIDINONE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
KUNMING INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
He, Yanping
Zhang, Hongbin
Zheng, Yongtang
Wu, Yumeng
Tang, Chengrun
Rui, Ruomei
Yang, Liumeng
Wang, Jiangyuan
Abrégé
31163623112366202106203a2103b441-6166 branched or linear alkoxy. The 2-thiomethylpyrazolopyrimidinone compound of the present invention can be used as an HIV-1 inhibitor and for the preparation of a drug for treating and/or preventing immunodeficiency viruses.
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
A61K 31/513 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p. ex. cytosine
A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
27.
DACOS TYPE NNRTIS AMINO ACID ESTER DERIVATIVE, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
KUNMING INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
He, Yanping
Zhang, Hongbin
Zheng, Yongtang
Zhang, Yufang
Tang, Chengrun
Ding, Wei
Yang, Liumeng
Li, Yiming
Abrégé
116 36211236112211221121126202106202a2102b323266 heterocycloalkyl group. The DACOs-type NNRTIs amino acid ester derivatives of the present invention can be used as HIV-1 inhibitors and for the preparation of a drug for treating and/or preventing immunodeficiency viruses.
C07D 239/56 - Un atome d'oxygène et un atome de soufre
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61K 31/513 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p. ex. cytosine
A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having an oxadiazole-oxadiazolone structure (e.g., oxadiazole-phenyl-oxadiazolone compounds, oxadiazole-pyridine-oxadiazolone compounds, oxadiazole-indole-oxadiazolone compounds, oxadiazole-quinoline-oxadiazolone compounds, oxadiazole-pyrrole-oxadiazolone compounds, and oxadiazole-vinyl-oxadiazolone compounds), and their use as therapeutics for the treatment of cancer and other diseases.
EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (Chine)
YUNNAN UNIVERSITY (Chine)
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Li, Honglin
Xiao, Weilie
Zhu, Lili
Quan, Lina
Li, Qiao
Diao, Yanyan
Zhao, Zhenjiang
Jiang, Hualiang
Abrégé
Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease.
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine liés à un système carbocyclique condensé, p. ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
A61K 31/7056 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à cinq chaînons avec l'azote comme hétéro-atome d'un cycle
A skid mounted device (4) of upper-spreading in-diffusion vertical pushing photocatalytic wastewater treatment, comprising in-diffusion vertical pushing photocatalytic reaction tank groups (2) and skid bases (7); the in-diffusion vertical pushing photocatalytic reaction tank groups (2) are arranged on the skid bases (7); the in-diffusion vertical pushing photocatalytic reaction tank groups (2) are connected to each other in series, in parallel, or in serial-parallel fashion; each in-diffusion vertical pushing photocatalytic reaction tank group (2) consists of two or more photocatalytic reaction tanks (21) connected in series, in parallel, or in serial-parallel fashion; and wastewater pipes (29) connected to the photocatalytic reaction tanks (21) in each in-diffusion vertical pushing photocatalytic reaction tank group (2) are mounted at the tops of the photocatalytic reaction tanks (21). The photocatalytic reaction tanks (21) and the photocatalytic reaction tank groups (2) are connected in series, in parallel, or in serial-parallel fashion, improving the wastewater treatment efficiency and effect; moreover, components are arranged on the skid base (7) to form an integrated structure. The device is compact and simple in structure, convenient to install and detach, convenient to adjust and clean, low in maintenance and operation costs, plenty in decontamination types, high in efficiency and stable in running, easy in management, and applicable to all types of wastewater treatment.
Discloses is a method for synthesizing 4-hydroxybenzoic acid by using PX as a raw material. PX is dissolved in an organic solvent and undergoes oxidation reaction with an oxidant under the action of an M-MOF catalyst, after the reaction is completed, post-treatment is performed to obtain 4-hydroxybenzoic acid. The metal element M in the M-MOF catalyst is Fe, Cu, Cr, Mn, Cu/Fe, Cu/Cr, Cu/Mn, Fe/Mn, Cr/Fe or Cr/Mn. The raw materials of the present invention are abundant in sources and low in price; less by-products are generated in the reaction process, the yield is high, and separation is convenient; acid-base neutralization is not needed in the reaction process, and pollution is reduced; and the present invention is a one-step reaction and is mild in reaction conditions, short in reaction time, low in pollution, and convenient for industrialized scale-up production. The prepared 4-hydroxybenzoic acid can be used for preparing medicines, liquid crystal materials, etc., is widely used and has high value.
C07C 51/265 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par oxydation avec l'oxygène moléculaire de composés contenant des cycles aromatiques à six chaînons sans ouverture du cycle comportant des chaînes latérales alkylées qui sont oxydées en groupes carboxyle
C07C 51/285 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par oxydation avec des composés peroxydés
C07C 51/275 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par oxydation avec des oxydes d'azote ou des acides minéraux contenant de l'azote de groupes hydrocarbyle
C07C 51/305 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par oxydation avec du soufre ou des composés contenant du soufre
C07C 65/01 - Composés comportant des groupes carboxyle liés à des atomes de carbone de cycles aromatiques à six chaînons et contenant l'un des groupes OH, O-métal, —CHO, cétone, éther, des groupes , des groupes ou des groupes contenant des groupes hydroxyle ou O-métal
A reservoir tail reverse regulation method for native fish protection. The method comprises: firstly, determining a breeding habitat of native fishes at a reservoir tail of a cascade hydroelectric dam; then determining a breeding characteristic of migrating native fishes, and carrying out an ecological conservation project on a reach of the breeding habitat at the reservoir tail; afterwards, by means of field investigation, determining the length of the reservoir tail of a downstream hydropower station of a cascade hydroelectric project between March and May, and recognizing the maximum range of a natural river course downstream of an upstream cascade power station dam; and finally, reversely regulating the flow state of the reach at the reservoir tail, so as to achieve the goals of exposing the natural river course at the reservoir tail and ensuring the natural flow state of the natural river course.
FOOD CROPS RESEARCH INSTITUTE,YUNNAN ACADEMY OF AGRICULTURAL SCIENCES (Chine)
Inventeur(s)
Hu, Fengyi
Zhang, Shilai
Huang, Liyu
Tao, Dayun
Zhang, Jing
Huang, Guangfu
Hu, Jian
Dao, Jinrong
Abrégé
A method for cultivating perennial rice having perenniality using an asexual propagation characteristic of oryza longistaminata, wherein a perennial rice carrying a perennial genetic locus of oryza longistaminata and adapting to different ecological types is cultivated, which makes it possible to harvest for two or more years by means of planting only once, thereby increasing efficiency of rice cultivation and production.
FOOD CROPS RESEARCH INSTITUTE, YUNNAN ACADEMY OF AGRICULTURAL SCIENCES (Chine)
Inventeur(s)
Hu, Fengyi
Huang, Liyu
Zhang, Shilai
Huang, Guangfu
Zhang, Jing
Abrégé
Provided are a method and an application for stabilizing hybrid vigor by utilizing vegetative propagation characteristics of oryza longistaminata. The method comprises the steps: cultivating perennial hybrid rice by utilizing the vegetative propagation characteristics of oryza longistaminata, and stabilizing the hybrid vigor. According to the method and application of the invention, a rice cultivation production manner of continuously harvesting hybrid rice for many years (repeatedly) by planting once due to vegetative propagation is realized, the hybrid vigor of rice cultivation is stabilized, the rice production cost is reduced, and the rice production benefits are improved.
The invention relates to the field of metal-organic framework materials and the field of medical technology, relates to a method for inhibiting tumor angiogenesis or preventing and/or treating tumor, comprising administering to a subject in need thereof an effective amount of a metal-organic framework comprising Fe and ligand. The invention further relates to a method for inhibiting the expression of matrix metalloproteinase in a cell, comprising administering to the cell an effective amount of a metal-organic framework comprising Fe and ligand.
An antidepressant and screening method thereof. An active pharmaceutical ingredient of the antidepressant targets a dendritic-cell-associated C-type lectin-1. The antidepressant exerts an antidepressant effect by binding, activating, and/or increasing the expression of the dendritic-cell-associated C-type lectin-1. The active pharmaceutical ingredient is a β-glucan.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
37.
USE OF MAITAKE AND MAITAKE GRIFOLAN D COMPONENT IN PREPARATION OF ANTIDEPRESSANT DRUG
A use of maitake, maitake extract and/or maitake polysaccharide D component serving as an active ingredient in the preparation of an antidepressant drug; the drug is used to treat or prevent depressive disorder, and has a marked antidepressant effect and no toxic and side effect such as inducing epilepsy or ataxia.
A nitrogen oxide ammonia-free low-temperature selective reduction catalyst, a preparation method therefor, and uses thereof. The catalyst comprises active components and carriers. The active components comprise manganese oxide and copper oxide. The mass percentages of the components in the catalyst are: manganese oxide accounts for 1-15%, copper oxide accounts for 1-8%, and carrier residues. The catalyst can satisfy a flue gas denitrification process in a low-temperature condition, and the ammonia as a reduction catalyst is not required when denitrification is conducted, and accordingly, processing costs of an enterprise can be effectively reduced. When flue gas denitrification is conducted by using the catalyst, CO and H2 comprised in flue gas can meet reduction requirements in the denitrification; even in the later stage of the processing, the denitrification is incomplete due to the activity reduction of the catalyst, the denitrification can be normally conducted by means of conversion of two denitrification reduction catalysis towers; in another denitrification reduction catalysis tower, NOx or nitrate or nitrite is reduced to N2 under the action of the introduction of water gas, and meanwhile, the objective of reactivating the catalyst is achieved.
KUNMING INSTITUTE OF BOTANY, THE CHINESE ACADEMY OF SCIENCES (Chine)
YUNNAN UNIVERSITY (Chine)
KUNMING INSTITUTE OF ZOOLOGY, THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Liu, Jingping
Sun, Handong
Zhang, Hongbin
Zheng, Yongtang
Xiao, Weilie
Pu, Jianxin
Wang, Ruirui
Yang, Liumeng
Abrégé
Nitrogen-containing biphenyl compounds as represented by formula (I), pharmaceutically acceptable salts or derivatives thereof, pharmaceutical compositions, and preparation methods therefore, and anti-HIV-1 use of the compound. Each substituent group in formula (I) is as defined in the description.
Medicinal compounds with general formula (I) in medicine health and chemistry field. 13-halo-3,15-dioxy gibberellic acid esters and the preparation methods thereof. Antitumor activity experiments prove that these compounds have higher antitumor effects and low toxicity to normal cells. R1=CH3, Alkyl with 2-5 carbon atoms, PhCH2 R2=F, Cl, Br, I.
C07D 307/77 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle condensés en ortho ou en péri avec des carbocycles ou avec des systèmes carbocycliques
A61K 31/343 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à cinq chaînons avec un oxygène comme seul hétéro-atome d'un cycle, p. ex. isosorbide condensés avec un carbocycle, p. ex. coumarane, bufaralol, béfunolol, clobenfurol, amiodarone
brevets
