C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
G16B 25/10 - Profilage de l’expression de gènes ou de protéinesEstimation ou normalisation de ratio d’expression
Techniques are provided for generating an array-specific range of Tm values to be used for calling a sample in a given array positive or negative for a target nucleic acid sequence. A sample well in an array is provided with a control sample containing a control nucleic acid sequence. The control sample is amplified by thermal cycling the sample well. A Tm value for the control sample is identified and compared to an expected Tm value for the control nucleic acid sequence to calculate a relationship between the identified control Tm value and the expected control Tm value. By applying this relationship to an expected Tm value for a target nucleic acid sequence, an array-specific range of Tm values for the target nucleic acid sequence is generated and can be used for calling an experimental sample in the same array positive or negative for the target nucleic acid sequence.
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include nucleic acid amplification and detection and immuno-PCR.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Chemical preparations for industry and research; chemical
preparations for scientific use; chemical reagents and
biological preparations for diagnosis, other than for
medical use; reagents and culture media for the control,
detection, diagnosis and analysis of contaminating
microorganisms and substances in industrial, agri-food,
cosmetic and pharmaceutical products; reagents and media
enabling the control, diagnosis and analysis of
contaminating microorganisms and substances for detecting
biological threats and monitoring epidemics and pandemics. Reagents and culture media for medical and veterinary
diagnosis; laboratory reagents for use in clinical, medical
or veterinary laboratories; chemical, biochemical and
biological preparations for use in the medical and
veterinary fields; reagents and culture media for medical
and veterinary use enabling the control, diagnosis and
analysis of contaminating microorganisms and substances for
detecting biological threats and monitoring epidemics and
pandemics. Diagnostic apparatus and instruments, not for medical use;
scientific analysis and diagnostic apparatus and
instruments, other than for medical use; laboratory
instruments; Scientific apparatus and instruments for the
monitoring, detection, diagnosis and analysis of
contaminating substances in industrial, agri-food, cosmetic,
pharmaceutical and veterinary products; scientific apparatus
and instruments enabling the control, diagnosis and analysis
of contaminating microorganisms and substances for detecting
biological threats and monitoring epidemics and pandemics;
software for analyzing, processing and interpreting medical
and veterinary test results in the field of in vitro
diagnosis. Apparatus and instruments for medical and veterinary
diagnostic purposes; apparatus and instruments for medical
and veterinary use enabling the control, diagnosis and
analysis of contaminating microorganisms and substances for
detecting biological threats and monitoring epidemics and
pandemics.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Chemical preparations for industry and research; chemical preparations for scientific use; chemical reagents and biological preparations for use in science for diagnosis, other than for medical use; reagents and cell culture media other than for medical or veterinary purposes for the control, detection, diagnosis and analysis of contaminating microorganisms and substances in industrial, agri-food, cosmetic and pharmaceutical products; reagents and cell culture media for scientific and research use enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics Reagents and cell culture media for medical and veterinary diagnosis; laboratory reagents for use in clinical, medical or veterinary laboratories for medical and veterinary purposes; chemical, biochemical and biological preparations for use in the medical and veterinary fields for the control, detection, diagnosis and analysis of contaminating microorganisms for medical and veterinary diagnostic purposes; reagents and cell culture media for medical and veterinary use enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics Diagnostic apparatus and instruments for the detection of microorganisms, not for medical use; laboratory instruments, namely, laboratory instruments for detecting microorganisms; Scientific apparatus and instruments for the monitoring, detection, diagnosis and analysis of contaminating substances in industrial, agri-food, cosmetic, pharmaceutical and veterinary products; scientific apparatus and instruments enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics; downloadable software for analyzing, processing and interpreting medical and veterinary test results in the field of in vitro diagnosis Apparatus and instruments for detecting microorganisms for medical and veterinary diagnostic purposes; apparatus and instruments for medical and veterinary use enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Préparations chimiques pour l'industrie et la recherche; préparations chimiques à usage scientifique; réactifs chimiques et préparations biologiques pour le diagnostic, autres qu'à usage médical; réactifs et milieux de culture pour le contrôle, la détection, le diagnostic et l'analyse des microorganismes et des substances contaminantes dans les produits industriels, agro-alimentaires, cosmétiques et pharmaceutiques; réactifs et milieux permettant le contrôle, le diagnostic et l'analyse des microorganismes et des substances contaminantes pour la détection des menaces biologiques et la surveillance des épidémies et pandémies.
(2) Réactifs et milieux de culture pour le diagnostic médical et vétérinaire; réactifs de laboratoire destinés aux laboratoires cliniques, médicaux ou vétérinaires; préparations chimiques, biochimiques et biologiques destinées aux domaines médical et vétérinaire; réactifs et milieux de culture à usage médical et vétérinaire permettant le contrôle, le diagnostic et l'analyse des microorganismes et des substances contaminantes pour la détection des menaces biologiques et la surveillance des épidémies et pandémies.
(3) Appareils et instruments de diagnostic, non à usage médical; appareils et instruments scientifiques d'analyse et de diagnostics, autres qu'à usage médical; instruments de laboratoire; appareils et instruments scientifiques pour le contrôle, la détection, le diagnostic et l'analyse des substances contaminantes dans les produits industriels, agroalimentaires, cosmétiques, pharmaceutiques et vétérinaires; appareils et instruments scientifiques permettant le contrôle, le diagnostic et l'analyse des microorganismes et des substances contaminantes pour la détection des menaces biologiques et la surveillance des épidémies et pandémies; logiciels pour l'analyse, le traitement et l'interprétation de résultats de tests médicaux et vétérinaires dans le domaine du diagnostic in vitro.
(4) Appareils et instruments pour le diagnostic médical et vétérinaire; appareils et instruments à usage médical et vétérinaire permettant le contrôle, le diagnostic et l'analyse des microorganismes et des substances contaminantes pour la détection des menaces biologiques et la surveillance des épidémies et pandémies.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Chemicals used in industry, Chemical preparations for research; Chemical preparations for scientific purposes; Chemical diagnostic reagents, Biological diagnostic preparations, not for medical purposes; Reagents and Growing media, for use in the following fields: Monitoring, detection, diagnosis and analysis of microorganisms and contaminants in industrial goods, agri-foodstuffs, cosmetics and pharmaceuticals; Reagents and media for monitoring, diagnosing and analysing microorganisms and contaminants, for use in the following fields: Detection of biological threats and surveillance of epidemics and pandemics. Reagents and culture media, for use in the following fields: medical diagnosis and Veterinary diagnosis; Laboratory reagents for clinical, medical or veterinary laboratories; Chemical, biochemical and biological preparations, for use in the following fields: Medicine and Veterinary medicine; Reagents and media enabling the monitoring, diagnosis and analysis of microorganisms and contaminants, For medical purposes and Veterinary use, for use in the following fields: Detection of biological threats and surveillance of epidemics and pandemics. Diagnostic apparatus and instruments, not for medical purposes; Scientific analysis and diagnostic apparatus and instruments, Not for medical purposes; Laboratory instruments; Scientific apparatus and instruments, for use in the following fields: Monitoring, detection, diagnosis and analysis of contaminants in industrial goods, agri-foodstuffs, cosmetics, pharmaceuticals and veterinary goods; Scientific apparatus and instruments for monitoring, diagnosing and analysing microorganisms and contaminants, for use in the following fields: Detection of biological threats and surveillance of epidemics and pandemics; Software for analysis, processing and interpretation of medical and veterinary test results in the field of in vitro diagnosis. Instruments and apparatus for medical and veterinary diagnosis; Apparatus and instruments for monitoring, diagnosing and analysing microorganisms and contaminants, For medical and veterinary purposes, for use in the following fields: Detection of biological threats and surveillance of epidemics and pandemics.
12.
SYSTEMS AND METHODS FOR TARGETING TESTING PANEL BASED ON TEMPORAL, GEOGRAPHIC, AND DEMOGRAPHIC DATA
Methods for targeting the results provided by a testing panel based on patient population data are provided, comprising: identifying, by one or more processors, a set of relevant pathogen groups for each of a respective one or more populations of interest; obtaining, by the one or more processors, pathogen testing results for a particular individual, corresponding to a plurality of pathogen groups; and reporting, by the one or more processors, to a device associated with an individual or a medical provider of the individual, the pathogen testing results for the particular individual, corresponding to the set of relevant pathogen groups for a population, of the one or more populations of interest, with which the individual is associated.
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G16H 50/80 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la détection, le suivi ou la modélisation d’épidémies ou des pandémies, p. ex. de la grippe
G16H 10/00 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients
Methods and devices are provided for simultaneously amplifying a plurality of sample wells for a predetermined amount of amplification, detecting whether amplification has occurred in a first set of the wells, amplifying for an additional amount of amplification and detecting whether amplification has occurred in a second set of the wells. Methods are also provided for analyzing a target nucleic acid sequence using melt curves that were generated in a plurality of amplification cycles.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
G16B 25/10 - Profilage de l’expression de gènes ou de protéinesEstimation ou normalisation de ratio d’expression
G01N 33/94 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des narcotiques
The present disclosure relates to methods and systems suitable for simultaneously amplifying a number of potential targets and then performing a melt detection based on whether or not any amplification is detected for any target nucleic acid(s), wherein the melt parameters are limited by the melt temperature range characteristic for the target nucleic acid(s) for which amplification is detected. This invention retains the resolution achieved by nucleic acid melts with a slow, steady ramp rate between the annealing and denaturation temperatures, but does so faster by using faster ramp rates at temperatures where no melt signature is expected from the reaction, and slower at temperatures where a melt signature is expected from the reaction.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/24 - Méthodes d'échantillonnage, d'inoculation ou de développement d'un échantillonMéthodes pour isoler physiquement un micro-organisme intact
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include nucleic acid amplification and detection and immuno-PCR.
Techniques are provided for generating an array-specific range of Tm values to be used for calling a sample in a given array positive or negative for a target nucleic acid sequence. A sample well in an array is provided with a control sample containing a control nucleic acid sequence. The control sample is amplified by thermal cycling the sample well. A Tm value for the control sample is identified and compared to an expected Tm value for the control nucleic acid sequence to calculate a relationship between the identified control Tm value and the expected control Tm value. By applying this relationship to an expected Tm value for a target nucleic acid sequence, an array-specific range of Tm values for the target nucleic acid sequence is generated and can be used for calling an experimental sample in the same array positive or negative for the target nucleic acid sequence.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
C12Q 1/24 - Méthodes d'échantillonnage, d'inoculation ou de développement d'un échantillonMéthodes pour isoler physiquement un micro-organisme intact
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Downloadable software aimed at medical and/or veterinary fields, namely downloadable software for conducting medical and veterinary diagnostics; Computer software aimed at medical and/or veterinary fields, namely downloadable software for conducting medical and veterinary diagnostics. Software as a service [SAAS] services aimed at medical and/or veterinary fields featuring software for conducting medical and veterinary diagnostics.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Chemical, biochemical and biological preparations for use in
industry, science and research; diagnostic reagents for use
in biochemistry, clinical chemistry, biology and
microbiology diagnosis for use in industry, science and
research; reagents and media for the verification,
detection, diagnosis and analysis of contaminants in
industrial, food industry, cosmetic and pharmaceutical
products, not for medical or veterinary use. Reagents and media for medical and veterinary diagnosis;
chemical, biochemical and biological preparations for use in
the pharmaceutical, medical and veterinary fields for the
diagnosis of infectious disease and the in-vitro diagnosis
of medical diseases or general medical conditions for humans
and animals.
26.
APPARATUSES, METHODS, AND SYSTEMS FOR IN-SITU SEALING OF REACTION CONTAINERS
Systems, methods, and apparatus are provided for in-situ sealing of reaction wells. This invention provides reaction containers, methods, and systems for in-situ sealing of individual reaction wells illustratively in a closed reaction container using the conditions already present in a reaction (e.g., a thermocycling reaction) to deform a sealing material to seal the reaction wells and create a seal that is present during the reaction and that remains after the reaction is complete.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
B32B 3/30 - Produits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche continue dont le périmètre de la section droite a une allure particulièreProduits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche comportant des cavités ou des vides internes caractérisés par une couche comportant des retraits ou des saillies, p. ex. des gorges, des nervures
B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
B32B 27/36 - Produits stratifiés composés essentiellement de résine synthétique comprenant des polyesters
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Chemical, biochemical and biological preparations for use in industry, science and research; diagnostic reagents for use in biochemistry, clinical chemistry, biology and microbiology diagnosis for use in industry, science and research; reagents and media for the verification, detection, diagnosis and analysis of contaminants in industrial, food industry, cosmetic and pharmaceutical products, not for medical or veterinary use. Reagents and media for medical and veterinary diagnosis; Chemical, biochemical and biological preparations for use in the pharmaceutical, medical and veterinary fields for the diagnosis of infectious disease and the in-vitro diagnosis of medical diseases or general medical conditions for humans and animals.
Methods and devices are provided for simultaneously amplifying a plurality of sample wells for a predetermined amount of amplification, detecting whether amplification has occurred in a first set of the wells, amplifying for an additional amount of amplification and detecting whether amplification has occurred in a second set of the wells. Methods are also provided for analyzing a target nucleic acid sequence using melt curves that were generated in a plurality of amplification cycles.
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
32.
METHODS FOR NORMALIZATION AND QUANTIFICATION OF SEQUENCING DATA
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
33.
SYSTEM AND METHOD FOR IDENTIFYING ANALYTES IN ASSAY USING NORMALIZED TM VALUES
Techniques are provided for generating an array-specific range of Tm values to be used for calling a sample in a given array positive or negative for a target nucleic acid sequence. A sample well in an array is provided with a control sample containing a control nucleic acid sequence. The control sample is amplified by thermal cycling the sample well. A Tm value for the control sample is identified and compared to an expected Tm value for the control nucleic acid sequence to calculate a relationship between the identified control Tm value and the expected control Tm value. By applying this relationship to an expected Tm value for a target nucleic acid sequence, an array-specific range of Tm values for the target nucleic acid sequence is generated and can be used for calling an experimental sample in the same array positive or negative for the target nucleic acid sequence.
Methods, sample vessels, and instruments are provided for melting curve analysis. A sample is amplified by thermal cycling the sample well between at least an annealing temperature and a denaturation temperature through n cycles, where each cycle includes an in-cycle denaturation step. Fluorescent data is collected during the in-cycle denaturation step of n cycles where n is at least two. Then a composite melting curve is generated using the fluorescent data collected during the denaturation step of each of the n cycles, and the sample is called using the composite melting curve, where the call is a positive or a negative call.
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include high density nucleic acid amplification and detection and immuno-PCR.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Chemical, biochemical and biological preparations for use in industry, science and research; diagnostic reagents for use in biochemistry, clinical chemistry, biology and microbiology diagnosis for use in industry, science and research; reagents and media for the verification, detection, diagnosis and analysis of contaminants in industrial, food industry, cosmetic and pharmaceutical products, not for medical or veterinary use Reagents and media for medical and veterinary diagnosis; Chemical, biochemical and biological preparations for use in the pharmaceutical, medical and veterinary fields for the diagnosis of infectious disease and the in-vitro diagnosis of medical diseases or general medical conditions for humans and animals
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include nucleic acid amplification and detection and immuno-PCR.
Systems, methods, and apparatus are provided for in-situ sealing of reaction wells. This invention provides reaction containers, methods, and systems for in-situ sealing of individual reaction wells illustratively in a closed reaction container using the conditions already present in a reaction (e.g., a thermocycling reaction) to deform a sealing material to seal the reaction wells and create a seal that is present during the reaction and that remains after the reaction is complete.
Devices and methods are provided for spotting an array with fluid. Arrays produced by such methods are also provided. In one aspect of the invention, a spotter device for spotting a plurality of fluids into an array is described, the spotter device comprising a plurality of reservoirs provided in a first configuration, each reservoir holding its respective fluid, a print head having a plurality of positions provided in a second configuration, the second configuration being different from the first configuration, a plurality of tubes, each tube configured to provide fluid communication from a reservoir at a first end of the tube to a position in the print head at the second end of the tube, and a pump for pumping fluid through the tubes from the reservoir to the print head.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
In one illustrative embodiment, a cannulated vial is provided, the cannulated vial comprising a vial body having a top surface at one end, a bottom surface at an opposite end, and exterior wall therebetween defining an interior vial volume, the top surface having an opening, a cannula extending from the bottom surface and having a first end, a second end and an outer surface therebetween defining a cannula volume, the first end in fluid communication with the interior vial volume, and a cap having a tongue, the tongue sized to sealably close the opening, the tongue further having a volume greater than or equal to the cannula volume.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
G06F 19/18 - pour la génomique ou la protéomique fonctionnelle, p.ex. associations génotype-phénotype, déséquilibre de liaison, mutagénèse, génotypage ou annotation génomique, interactions protéines-protéines ou interactions protéines-acides nucléiques
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Chemical preparations; chemical preparations or biochemical
preparations and chemical or biochemical reagents for use in
industry and science; laboratory chemical and biochemical
reagents other than for medical or veterinary use; chemical
and biochemical reagents and chemical or biochemical assays
for use in the industrial, agri-food, cosmetic,
pharmaceutical, environmental fields, other than for medical
or veterinary use; reagents and assays for scientific
research or laboratory use; chemical preparations, chemical
reagents and assays for use in environmental bio-threat
detection and pandemic bio-surveillance. Chemical and biochemical reagents for medical,
pharmaceutical or veterinary purposes; biological reagents,
namely, biological preparations for the detection, analysis
and quantification of microbial contaminants; chemical
reagents and culture media for in-vitro medical,
pharmaceutical and veterinary diagnosis; medical diagnostic
reagents and assays that test for the presence of pathogens
and infection; medical diagnostic kits comprised of medical
diagnostic reagents and assays that test for the presence of
pathogens and infection; medical diagnostic reagents and
assays that test body fluids for microorganisms; medical
diagnostic kits comprised of medical diagnostic reagents and
assays that test body fluids for microorganisms; medical
diagnostic reagents for the extraction, amplification, and
purification of nucleic acids; clinical medical reagents and
assays for the extraction, amplification, and purification
of nucleic acids. Scientific apparatus and instruments for in-vitro diagnosis
not for medical use for industrial applications in the
agri-food, cosmetic, pharmaceutical and environmental
fields; kits comprised of laboratory instruments for
environmental bio-threat detection and pandemic
bio-surveillance as well as reagents and assays; laboratory
equipment, namely, instruments for the detection in
biological samples of pathogen targets in the nature of
viruses, bacteria, fungi, protozoa pathogens, yeast,
parasites and antibiotic resistance genes; laboratory
equipment, namely, kits comprising instruments for the
detection in biological samples of pathogen targets in the
nature of viruses, bacteria, fungi, protozoa pathogens,
yeast, parasites and antibiotic resistance genes; diagnostic
apparatus for the detection of virus, bacteria, fungi,
protozoa pathogens, yeast, parasites and antibiotic
resistance genes for laboratory or research use; diagnostic
kits comprised of diagnostic apparatus for the detection of
virus and bacteria pathogens and antibiotic resistance genes
for laboratory or research use; scientific apparatus and
instruments for in-vitro diagnosis not for medical use for
industrial applications in the agri-food, cosmetic,
pharmaceutical and environmental fields; computer software
used in the field of in-vitro diagnosis. Diagnostic apparatus for the detection of virus, bacteria,
fungi, protozoa pathogens, parasites, yeasts and antibiotic
resistance genes for medical use; diagnostic kits comprised
of diagnostic apparatus for the detection of virus,
bacteria, fungi, protozoa pathogens, parasites, yeasts and
antibiotic resistance genes for medical use.
G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Chemical preparations; chemical preparations or biochemical preparations and chemical or biochemical reagents for use in industry and science; laboratory chemical and biochemical reagents other than for medical or veterinary use; chemical and biochemical reagents and chemical or biochemical assays for use in the industrial, agri-food, cosmetic, pharmaceutical, environmental fields, other than for medical or veterinary use; reagents and assays for scientific research or laboratory use; chemical preparations, chemical reagents and assays for use in environmental bio-threat detection and pandemic bio-surveillance. Chemical and biochemical reagents for medical, pharmaceutical or veterinary purposes; biological reagents, namely, biological preparations for the detection, analysis and quantification of microbial contaminants; chemical reagents and culture media for in-vitro medical, pharmaceutical and veterinary diagnosis; medical diagnostic reagents and assays that test for the presence of pathogens and infection; medical diagnostic kits comprised of medical diagnostic reagents and assays that test for the presence of pathogens and infection; medical diagnostic reagents and assays that test body fluids for microorganisms; medical diagnostic kits comprised of medical diagnostic reagents and assays that test body fluids for microorganisms; medical diagnostic reagents for the extraction, amplification, and purification of nucleic acids; clinical medical reagents and assays for the extraction, amplification, and purification of nucleic acids. Scientific apparatus and instruments for in-vitro diagnosis not for medical use for industrial applications in the agri-food, cosmetic, pharmaceutical and environmental fields; kits comprised of laboratory instruments for environmental bio-threat detection and pandemic bio-surveillance as well as reagents and assays; laboratory equipment, namely, instruments for the detection in biological samples of pathogen targets in the nature of viruses, bacteria, fungi, protozoa pathogens, yeast, parasites and antibiotic resistance genes; laboratory equipment, namely, kits comprising instruments for the detection in biological samples of pathogen targets in the nature of viruses, bacteria, fungi, protozoa pathogens, yeast, parasites and antibiotic resistance genes; diagnostic apparatus for the detection of virus, bacteria, fungi, protozoa pathogens, yeast, parasites and antibiotic resistance genes for laboratory or research use; diagnostic kits comprised of diagnostic apparatus for the detection of virus and bacteria pathogens and antibiotic resistance genes for laboratory or research use; scientific apparatus and instruments for in-vitro diagnosis not for medical use for industrial applications in the agri-food, cosmetic, pharmaceutical and environmental fields. Diagnostic apparatus for the detection of virus, bacteria, fungi, protozoa pathogens, parasites, yeasts and antibiotic resistance genes for medical use; diagnostic kits comprised of diagnostic apparatus for the detection of virus, bacteria, fungi, protozoa pathogens, parasites, yeasts and antibiotic resistance genes for medical use.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Chemical preparations for detecting and testing pathogens in the agri-food, cosmetic, pharmaceutical and environmental fields, biochemical preparations for detecting and testing pathogens in the agri-food, cosmetic, pharmaceutical and environmental fields; Reagents and assays for scientific research or laboratory use, namely diagnostic reagents for scientific research use that test for pathogens in the agri-food, cosmetic, pharmaceutical and environmental fields; Chemical preparations, chemical reagents and assays for use in environmental bio-threat detection and pandemic bio-surveillance, for detecting and testing biothreat pathogens in environmental samples being air, water, soil and powder samples.
(2) Chemical and biochemical reagents for the detection of microorganisms for the diagnosis of disease in the medical or veterinary field; Medical diagnostic reagents and assays that test for the presence of pathogens and infection; Medical diagnostic reagents and assays that test body fluids for microorganisms for detecting infectious disease
(3) Scientific apparatus and instruments, namely molecular biology analyzers for the detection of microorganisms in the agri-food, cosmetic, pharmaceutical and environmental fields; Laboratory instruments for the detection of pathogens, infection, and toxins in biological samples in the nature of viruses, bacteria, fungi, protozoa pathogens, yeast, parasites and antibiotic resistance genes.
(4) Diagnostic apparatus for use in the diagnosis of virus, bacteria, fungi, protozoa pathogens, parasites, yeasts and antibiotic resistance genes for medical use; Diagnostic kits comprised of diagnostic apparatus, namely molecular biology analyzers for the detection of virus, bacteria, fungi, protozoa pathogens, parasites, yeasts and antibiotic resistance genes for medical use
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
Methods and devices are provided for simultaneously amplifying a plurality of sample wells for a predetermined amount of amplification, detecting whether amplification has occurred in a first set of the wells, amplifying for an additional amount of amplification and detecting whether amplification has occurred in a second set of the wells. Methods are also provided for analyzing a target nucleic acid sequence using melt curves that were generated in a plurality of amplification cycles.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Chemical and biochemical reagents for medical purposes; biological reagents, namely, biological preparations for the detection, analysis and quantification of microbial contaminants for medical diagnosis and for research purposes; chemical reagents and culture media for in-vitro medical diagnosis; Medical diagnostic reagents and assays that test for the presence of pathogens and infection; Medical diagnostic kits comprised of medical diagnostic reagents and assays that test for the presence of pathogens and infection; Medical diagnostic reagents and assays that test body fluids for microorganisms; Medical diagnostic kits comprised of medical diagnostic reagents and assays that test body fluids for microorganisms; Medical diagnostic reagents for the extraction, amplification, and purification of nucleic acids; Clinical medical reagents and assays for the extraction, amplification, and purification of nucleic acids Kits comprised of laboratory instruments for pandemic bio-surveillance as well as reagents and assays; Laboratory equipment, namely, instruments for the detection in biological samples of pathogen targets in the nature of viruses, bacteria; Laboratory equipment, namely, kits comprising instruments for the detection in biological samples of pathogen targets in the nature of viruses, bacteria,; Diagnostic apparatus for the detection of virus and bacteria for laboratory or research use; Diagnostic kits comprised of diagnostic apparatus for the detection of virus and bacteria pathogens for laboratory or research use.; computer software used in the field of in-vitro diagnosis for detecting, identifying, classifying, testing, analyzing, measuring, preparing, testing, biochemical, biological, genetic pathogens, bacteria, germs, viruses, diseases, contagions, materials and samples Diagnostic apparatus for the detection of virus and bacteria for medical use; Diagnostic kits comprised of diagnostic apparatus for the detection of virus and bacteria for medical use
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include high density nucleic acid amplification and detection and immune-PCR.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
Methods and containers are provided for identifying a species, illustratively a bacterial species. Illustrative methods comprise amplifying various genes in the nucleic acid from the bacterial species in a single reaction mixture using pairs of outer first-stage primers designed to hybridize to generally conserved regions of the respective genes to generate a plurality of first-stage amplicons, dividing the reaction mixture into a plurality of second-stage reactions, each using a unique pair of second-stage primers, each pair of second-stage primers specific for a target bacterial species or subset of bacterial species, detecting which of the second-stage reactions amplified, and identifying the bacterial species based on second-stage amplification. Methods for determining antibiotic resistance are also provided, such methods also using first-stage primers for amplifying genes known to affect antibiotic resistance a plurality of the second-stage reactions wherein each pair of second-stage primers specific for a specific gene for conferring antibiotic resistance.
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Biochemical and chemical reagents used for non-medical purposes for collecting, analyzing, checking and detecting contaminants in food, blood, industrial preparations, or in the environment of such preparations, namely in water, air or work surfaces; diagnostic reagents for scientific or research use, namely diagnostic reagents for collecting, analyzing, checking and detecting contaminants, or in the environment of such preparations, namely in water, air or work surfaces; Freeze-dried reagents for purification of DNA/RNA; Chemical products, namely, reagents, control solutions and control reagents, buffers, dyes and kits comprised of the foregoing, for scientific, research, industrial, quality control and calibration purposes, and for laboratory and field use in the environmental fields for treating environments or for use in testing the condition of environments, testing food, water, blood, air, and other liquids, powders and substances, for use in rapid screening, biological processing and assay analysis; Enzymes for industrial use, namely, testing food, water, blood, air, and other liquids, powders and substances; DNA genetic primers, DNA nucleic acid primers, biochemical reagents commonly known as probes, genetic probes and nucleic acid probes for detecting and analyzing molecules in food, water, blood, air, and other liquids, powders and substances; enzymes for environmental diagnostic use, environmental clinical use, environmental laboratory use and for detection of contaminants in industrial settings; Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for scientific or research use in the biological, pathological, genetic, bio-defense and bio-surveillance fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for scientific or research use in the biological, pathological, genetic, environmental, clinical diagnostic, bio-defense and bio-surveillance fields, and for laboratory use.
(2) Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for use in the medical and veterinary fields; control solutions, control reagents, buffers and diagnostic agents and preparations for clinical medical, medical, and veterinary use.
(3) Laboratory devices, apparatus and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, light emitters such as lasers and light bulbs, lenses, mirrors, stations for placement of microtiter plates, microtiter plate readers; laboratory materials, articles and disposable, namely, optical filters, computer chips, thermal control elements for heating and cooling, sample containers, transformer connectors, batteries, battery chargers, testing sample pouches, testing sample pouch holders, syringes and plungers, carrying packs specially adapted for carrying all of the above-named goods, plastic or other sampling vials, plastic or other preparation vials; computer software, computer programs and associated instruction manuals all for use in detecting, identifying, classifying, tagging, labeling, amplifying, testing, analyzing, determining sequence, evaluating, monitoring, purifying, counting, mapping, engineering, expressing, measuring, preparing, testing, mixing, heating and cooling chemical, biochemical, biological, genetic, pathological and toxic agents, pathogens, bacteria, germs, viruses, diseases, contagions, materials and samples; computer software, computer programs and computer firmware all for use in controlling processes, inputting, analyzing, modifying, transferring, displaying, reporting and storing medical, biological, chemical, biochemical, genetic, pathological, environmental data and results; laptop computers, hard drives for computers and computer hardware; probes for environmental purpose, namely for detecting environmental contaminants; analytical instruments, namely, a laboratory instrument combining a rapid air thermocycling apparatus and a fluorimeter; laboratory equipment, namely, units for the purification and amplification of nucleic acids and devices used to heat and cool biological samples; bio-defense and bio-surveillance systems and instruments, and food and water security testing systems and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling; scientific apparatus and instruments for measuring DNA, RNA and protein and parts and fittings therefor.
(4) Medical apparatus, devices, equipment and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, scanners, microtiter plate readers, stations for placement of microtiter plates, lenses, mirrors, computers, instrument software, analytical software, and cases to hold the foregoing, all for detecting, identifying, classifying, analyzing, evaluating, monitoring, preparing, testing, mixing, heating and cooling nucleic acid, cells, genes and chemical, biochemical, biological, genetic, pathological and toxic materials and samples for medical, clinical and diagnostic purposes; medical materials, articles, apparatus and disposable items, namely, thermal control elements for heating and cooling, containers specially adapted for medical use to hold samples for testing purposes, tubes specially adapted for medical use for testing purposes, microtiter plates, plastic and metal receiver cartridges all for medical, surgical, veterinary, clinical and diagnostic use; nucleic acid amplifiers for medical use.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
G06F 19/22 - pour la comparaison de séquences impliquant des nucléotides ou des acides aminés, p.ex. recherche d'homologie, identification de motifs ou de polymorphismes de nucléotides simples [SNP] ou alignement de séquences
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
Devices and methods are provided for spotting an array with fluid. Arrays produced by such methods are also provided. In one aspect of the invention, a spotter device for spotting a plurality of fluids into an array is described, the spotter device comprising a plurality of reservoirs provided in a first configuration, each reservoir holding its respective fluid, a print head having a plurality of positions provided in a second configuration, the second configuration being different from the first configuration, a plurality of tubes, each tube configured to provide fluid communication from a reservoir at a first end of the tube to a position in the print head at the second end of the tube, and a pump for pumping fluid through the tubes from the reservoir to the print head.
Devices and methods are provided for collecting and handling difficult sample types. In one aspect of the present disclosure, a sample collection method is provided, the method comprising collecting a sample comprising a biological or environmental substance using a swab, placing the swab with the collected sample in a sample buffer, and filtering the sample. In various illustrative embodiments, the sample buffer may include a protease or a detergent and the sample may be collected and transferred to the sample buffer using a flocked swab.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
C12Q 3/00 - Procédés de commande sensible aux conditions du milieu
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
Methods for typing a strain of an organism are provided, the methods comprising the steps of amplifying, in a single reaction mixture containing nucleic acid from the organism, dividing the reaction mixture into a plurality of sets of second-stage reaction wells, each set of second-stage reaction wells containing a different pair of second-stage primers, subjecting each of the second-stage reaction wells to amplification conditions to generate a plurality of second-stage amplicons, melting the second-stage amplicons to generate a melting curve for each second-stage amplicon, and identifying the strain of the organism from the melting curves.
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyzes include high density nucleic acid amplification and detection and immune-PCR.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
Methods and devices are provided for simultaneously amplifying a plurality of sample wells for a predetermined amount of amplification, detecting whether amplification has occurred in a first set of the wells, amplifying for an additional amount of amplification and detecting whether amplification has occurred in a second set of the wells. Methods are also provided for analyzing a target nucleic acid sequence using melt curves that were generated in a plurality of amplification cycles.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Biochemical and chemical reagents used for non-medical
purposes; diagnostic reagents for scientific or research
use; freeze-dried reagents for purification of dna/rna;
chemical products, namely, reagents, control solutions and
control reagents, buffers, dyes and kits comprised of the
foregoing, for scientific, research, industrial, quality
control and calibration purposes, and for laboratory and
field use in the environmental fields for treating
environments or for use in testing the condition of
environments, testing food, water, blood, air, and other
liquids, powders and substances, for use with scientific and
research apparatus, and for use in rapid screening,
biological processing and assay analysis; enzymes for
industrial use, namely, testing food, water, blood, air, and
other liquids, powders and substances; dna genetic primers,
dna nucleic acid primers, biochemical reagents commonly
known as probes, genetic probes and nucleic acid probes for
detecting and analyzing molecules in food, water, blood,
air, and other liquids, powders and substances; enzymes for
environmental diagnostic use, environmental clinical use,
environmental laboratory use and industrial use; diagnostic
reagents, buffers, dyes, and kits comprised of the
foregoing, for scientific or research use in the biological,
pathological, genetic, bio-defense and bio-surveillance
fields; control solutions, control reagents, buffers and
diagnostic agents and preparations for scientific or
research use in the biological, pathological, genetic,
environmental, clinical diagnostic, bio-defense and
bio-surveillance fields, and for laboratory use. Diagnostic reagents, buffers, dyes, and kits comprised of
the foregoing, for use in the medical and veterinary fields;
control solutions, control reagents, buffers and diagnostic
agents and preparations for clinical medical, medical, and
veterinary use. Laboratory devices, apparatus and instruments, namely,
imaging devices comprising fluorimeters used to record
fluorescence signals and produce data, thermal control
elements for heating and cooling, light emitters such as
lasers and light bulbs, lenses, mirrors, stations for
placement of microtiter plates, microtiter plate readers;
laboratory materials, articles and disposable, namely,
optical filters, computer chips, thermal control elements
for heating and cooling, sample containers, transformer
connectors, batteries, battery chargers, testing sample
pouches, testing sample pouch holders, syringes and
plungers, carrying packs specially adapted for carrying all
of the above-named goods, plastic or other sampling vials,
plastic or other preparation vials; computer software,
computer programs and associated instruction manuals all for
use in detecting, identifying, classifying, tagging,
labeling, amplifying, testing, analyzing, determining
sequence, evaluating, monitoring, purifying, counting,
mapping, engineering, expressing, measuring, preparing,
testing, mixing, heating and cooling chemical, biochemical,
biological, genetic, pathological and toxic agents,
pathogens, bacteria, germs, viruses, diseases, contagions,
materials and samples; computer software, computer programs
and computer firmware all for use in controlling processes,
inputting, analyzing, modifying, transferring, displaying,
reporting and storing data and results; laptop computers,
hard drives for computers and computer hardware; probes for
environmental purpose; analytical instruments, namely, a
laboratory instrument combining a rapid air thermocycling
apparatus and a fluorimeter; laboratory equipment, namely,
units for the purification and amplification of nucleic
acids and devices used to heat and cool biological samples;
bio-defense and bio-surveillance systems and instruments,
and food and water security testing systems and instruments,
namely, imaging devices comprising fluorimeters used to
record fluorescence signals and produce data, thermal
control elements for heating and cooling; scientific
apparatus and instruments for measuring dna, rna and protein
and parts and fittings therefor. Medical apparatus, devices, equipment and instruments,
namely, imaging devices comprising fluorimeters used to
record fluorescence signals and produce data, thermal
control elements for heating and cooling, scanners,
microtiter plate readers, stations for placement of
microtiter plates, lenses, mirrors, computers, instrument
software, analytical software, and cases to hold the
foregoing, all for detecting, identifying, classifying,
analyzing, evaluating, monitoring, preparing, testing,
mixing, heating and cooling nucleic acid, cells, genes and
chemical, biochemical, biological, genetic, pathological and
toxic materials and samples for medical, clinical and
diagnostic purposes; medical materials, articles, apparatus
and disposable items, namely, thermal control elements for
heating and cooling, containers specially adapted for
medical use to hold samples for testing purposes, tubes
specially adapted for medical use for testing purposes,
microtiter plates, plastic and metal receiver cartridges all
for medical, surgical, veterinary, clinical and diagnostic
use; nucleic acid amplifiers for medical use.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Biochemical and chemical reagents used for non-medical
purposes; diagnostic reagents for scientific or research
use; freeze-dried reagents for purification of dna/rna;
chemical products, namely, reagents, control solutions and
control reagents, buffers, dyes and kits comprised of the
foregoing, for scientific, research, industrial, quality
control and calibration purposes, and for laboratory and
field use in the environmental fields for treating
environments or for use in testing the condition of
environments, testing food, water, blood, air, and other
liquids, powders and substances, for use with scientific and
research apparatus, and for use in rapid screening,
biological processing and assay analysis; enzymes for
industrial use, namely, testing food, water, blood, air, and
other liquids, powders and substances; dna genetic primers,
dna nucleic acid primers, biochemical reagents commonly
known as probes, genetic probes and nucleic acid probes for
detecting and analyzing molecules in food, water, blood,
air, and other liquids, powders and substances; enzymes for
environmental diagnostic use, environmental clinical use,
environmental laboratory use and industrial use; diagnostic
reagents, buffers, dyes, and kits comprised of the
foregoing, for scientific or research use in the biological,
pathological, genetic, bio-defense and bio-surveillance
fields; control solutions, control reagents, buffers and
diagnostic agents and preparations for scientific or
research use in the biological, pathological, genetic,
environmental, clinical diagnostic, bio-defense and
bio-surveillance fields, and for laboratory use. Diagnostic reagents, buffers, dyes, and kits comprised of
the foregoing, for use in the medical and veterinary fields;
control solutions, control reagents, buffers and diagnostic
agents and preparations for clinical medical, medical, and
veterinary use. Laboratory devices, apparatus and instruments, namely,
imaging devices comprising fluorimeters used to record
fluorescence signals and produce data, thermal control
elements for heating and cooling, light emitters such as
lasers and light bulbs, lenses, mirrors, stations for
placement of microtiter plates, microtiter plate readers;
laboratory materials, articles and disposable, namely,
optical filters, computer chips, thermal control elements
for heating and cooling, sample containers, transformer
connectors, batteries, battery chargers, testing sample
pouches, testing sample pouch holders, syringes and
plungers, carrying packs specially adapted for carrying all
of the above-named goods, plastic or other sampling vials,
plastic or other preparation vials; computer software,
computer programs and associated instruction manuals all for
use in detecting, identifying, classifying, tagging,
labeling, amplifying, testing, analyzing, determining
sequence, evaluating, monitoring, purifying, counting,
mapping, engineering, expressing, measuring, preparing,
testing, mixing, heating and cooling chemical, biochemical,
biological, genetic, pathological and toxic agents,
pathogens, bacteria, germs, viruses, diseases, contagions,
materials and samples; computer software, computer programs
and computer firmware all for use in controlling processes,
inputting, analyzing, modifying, transferring, displaying,
reporting and storing data and results; laptop computers,
hard drives for computers and computer hardware; probes for
environmental purpose; analytical instruments, namely, a
laboratory instrument combining a rapid air thermocycling
apparatus and a fluorimeter; laboratory equipment, namely,
units for the purification and amplification of nucleic
acids and devices used to heat and cool biological samples;
bio-defense and bio-surveillance systems and instruments,
and food and water security testing systems and instruments,
namely, imaging devices comprising fluorimeters used to
record fluorescence signals and produce data, thermal
control elements for heating and cooling; scientific
apparatus and instruments for measuring dna, rna and protein
and parts and fittings therefor. Medical apparatus, devices, equipment and instruments,
namely, imaging devices comprising fluorimeters used to
record fluorescence signals and produce data, thermal
control elements for heating and cooling, scanners,
microtiter plate readers, stations for placement of
microtiter plates, lenses, mirrors, computers, instrument
software, analytical software, and cases to hold the
foregoing, all for detecting, identifying, classifying,
analyzing, evaluating, monitoring, preparing, testing,
mixing, heating and cooling nucleic acid, cells, genes and
chemical, biochemical, biological, genetic, pathological and
toxic materials and samples for medical, clinical and
diagnostic purposes; medical materials, articles, apparatus
and disposable items, namely, thermal control elements for
heating and cooling, containers specially adapted for
medical use to hold samples for testing purposes, tubes
specially adapted for medical use for testing purposes,
microtiter plates, plastic and metal receiver cartridges all
for medical, surgical, veterinary, clinical and diagnostic
use; nucleic acid amplifiers for medical use.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Biochemical and chemical reagents used for non-medical
purposes; diagnostic reagents for scientific or research
use; freeze-dried reagents for purification of dna/rna;
chemical products, namely, reagents, control solutions and
control reagents, buffers, dyes and kits comprised of the
foregoing, for scientific, research, industrial, quality
control and calibration purposes, and for laboratory and
field use in the environmental fields for treating
environments or for use in testing the condition of
environments, testing food, water, blood, air, and other
liquids, powders and substances, for use with scientific and
research apparatus, and for use in rapid screening,
biological processing and assay analysis; enzymes for
industrial use, namely, testing food, water, blood, air, and
other liquids, powders and substances; dna genetic primers,
dna nucleic acid primers, biochemical reagents commonly
known as probes, genetic probes and nucleic acid probes for
detecting and analyzing molecules in food, water, blood,
air, and other liquids, powders and substances; enzymes for
environmental diagnostic use, environmental clinical use,
environmental laboratory use and industrial use; diagnostic
reagents, buffers, dyes, and kits comprised of the
foregoing, for scientific or research use in the biological,
pathological, genetic, bio-defense and bio-surveillance
fields; control solutions, control reagents, buffers and
diagnostic agents and preparations for scientific or
research use in the biological, pathological, genetic,
environmental, clinical diagnostic, bio-defense and
bio-surveillance fields, and for laboratory use. Diagnostic reagents, buffers, dyes, and kits comprised of
the foregoing, for use in the medical and veterinary fields;
control solutions, control reagents, buffers and diagnostic
agents and preparations for clinical medical, medical, and
veterinary use. Laboratory devices, apparatus and instruments, namely,
imaging devices comprising fluorimeters used to record
fluorescence signals and produce data, thermal control
elements for heating and cooling, light emitters such as
lasers and light bulbs, lenses, mirrors, stations for
placement of microtiter plates, microtiter plate readers;
laboratory materials, articles and disposable, namely,
optical filters, computer chips, thermal control elements
for heating and cooling, sample containers, transformer
connectors, batteries, battery chargers, testing sample
pouches, testing sample pouch holders, syringes and
plungers, carrying packs specially adapted for carrying all
of the above-named goods, plastic or other sampling vials,
plastic or other preparation vials; computer software,
computer programs and associated instruction manuals all for
use in detecting, identifying, classifying, tagging,
labeling, amplifying, testing, analyzing, determining
sequence, evaluating, monitoring, purifying, counting,
mapping, engineering, expressing, measuring, preparing,
testing, mixing, heating and cooling chemical, biochemical,
biological, genetic, pathological and toxic agents,
pathogens, bacteria, germs, viruses, diseases, contagions,
materials and samples; computer software, computer programs
and computer firmware all for use in controlling processes,
inputting, analyzing, modifying, transferring, displaying,
reporting and storing data and results; laptop computers,
hard drives for computers and computer hardware; probes for
environmental purpose; analytical instruments, namely, a
laboratory instrument combining a rapid air thermocycling
apparatus and a fluorimeter; laboratory equipment, namely,
units for the purification and amplification of nucleic
acids and devices used to heat and cool biological samples;
bio-defense and bio-surveillance systems and instruments,
and food and water security testing systems and instruments,
namely, imaging devices comprising fluorimeters used to
record fluorescence signals and produce data, thermal
control elements for heating and cooling; scientific
apparatus and instruments for measuring dna, rna and protein
and parts and fittings therefor. Medical apparatus, devices, equipment and instruments,
namely, imaging devices comprising fluorimeters used to
record fluorescence signals and produce data, thermal
control elements for heating and cooling, scanners,
microtiter plate readers, stations for placement of
microtiter plates, lenses, mirrors, computers, instrument
software, analytical software, and cases to hold the
foregoing, all for detecting, identifying, classifying,
analyzing, evaluating, monitoring, preparing, testing,
mixing, heating and cooling nucleic acid, cells, genes and
chemical, biochemical, biological, genetic, pathological and
toxic materials and samples for medical, clinical and
diagnostic purposes; medical materials, articles, apparatus
and disposable items, namely, thermal control elements for
heating and cooling, containers specially adapted for
medical use to hold samples for testing purposes, tubes
specially adapted for medical use for testing purposes,
microtiter plates, plastic and metal receiver cartridges all
for medical, surgical, veterinary, clinical and diagnostic
use; nucleic acid amplifiers for medical use.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Reagents and assays for scientific research or laboratory
use; reagents and assays for the extraction, amplification,
and purification of nucleic acids, for scientific research
or laboratory use; chemical reagents and assays not for
medical use, namely, for use in environmental bio-threat
detection and pandemic bio-surveillance. Medical diagnostic reagents and assays that test for the
presence of pathogens and infection; medical diagnostic kits
comprised of medical diagnostic reagents and assays that
test for the presence of pathogens and infection; medical
diagnostic reagents and assays that test body fluids for
microorganisms; medical diagnostic kits comprised of medical
diagnostic reagents and assays that test body fluids for
microorganisms; medical diagnostic reagents for the
extraction, amplification, and purification of nucleic
acids; clinical medical reagents and assays for the
extraction, amplification, and purification of nucleic
acids. Kits comprised of laboratory instruments for environmental
bio-threat detection and pandemic bio-surveillance as well
as reagents and assays; laboratory equipment, namely,
instruments for the detection in biological samples of
pathogen targets in the nature of viruses, bacteria, and
antibiotic resistance genes; laboratory equipment, namely,
kits comprising instruments for the detection in biological
samples of pathogen targets in the nature of viruses,
bacteria, and antibiotic resistance genes; diagnostic
apparatus for the detection of virus and bacteria pathogens
and antibiotic resistance genes for laboratory or research
use; diagnostic kits comprised of diagnostic apparatus for
the detection of virus and bacteria pathogens and antibiotic
resistance genes for laboratory or research use. Diagnostic apparatus for the detection of virus, bacteria,
fungi, protozoa pathogens and antibiotic resistance genes
for medical use; diagnostic kits comprised of diagnostic
apparatus for the detection of virus, bacteria, fungi,
protozoa pathogens and antibiotic resistance genes for
medical use.
C12Q 3/00 - Procédés de commande sensible aux conditions du milieu
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include nucleic acid amplification and detection and immuno-PCR.
Vials for loading a fluid system are provided. The illustrative vials are configured to minimize air bubbles from being transferred into the fluid system. Certain vial embodiments are provided with filters to allow microbes to pass into the fluidic system, while retaining larger particulate matter.
Methods and containers are provided for identifying a species, illustratively a bacterial species. Illustrative methods comprise amplifying various genes in the nucleic acid from the bacterial species in a single reaction mixture using pairs of outer first-stage primers designed to hybridize to generally conserved regions of the respective genes to generate a plurality of first-stage amplicons, dividing the reaction mixture into a plurality of second-stage reactions, each using a unique pair of second-stage primers, each pair of second-stage primers specific for a target bacterial species or subset of bacterial species, detecting which of the second-stage reactions amplified, and identifying the bacterial species based on second-stage amplification. Methods for determining antibiotic resistance are also provided, such methods also using first-stage primers for amplifying genes known to affect antibiotic resistance a plurality of the second-stage reactions wherein each pair of second-stage primers specific for a specific gene for conferring antibiotic resistance.
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Reagents and assays for scientific research and laboratory use, namely chemical reagents and assays for detecting and testing biothreat pathogens in environmental samples namely, air, water, soil and powder; Reagents and assays for the extraction, amplification, and purification of nucleic acids, for scientific research or laboratory use; Chemical reagents and assays not for medical use, namely, for use in environmental bio-threat detection and pandemic bio-surveillance; medical diagnostic reagents and assays that test for the presence of pathogens and infection; Medical diagnostic kits comprised of medical diagnostic reagents and assays that test for the presence of pathogens and infection; Medical diagnostic reagents and assays that test body fluids for microorganisms; Medical diagnostic kits comprised of medical diagnostic reagents and assays that test body fluids for microorganisms; medical diagnostic reagents for the extraction, amplification, and purification of nucleic acids; Clinical medical reagents and assays for the extraction, amplification, and purification of nucleic acids; Kits comprised of laboratory instruments for environmental bio-threat detection and pandemic bio-surveillance as well as reagents and assays; Laboratory equipment, namely, instruments for the detection in biological samples of pathogen targets in the nature of viruses, bacteria, and antibiotic resistance genes; Laboratory equipment, namely, kits comprising instruments for the detection in biological samples of pathogen targets in the nature of viruses, bacteria, and antibiotic resistance genes; Diagnostic apparatus for the detection of virus and bacteria pathogens and antibiotic resistance genes for laboratory or research use; Diagnostic kits comprised of diagnostic apparatus for the detection of virus and bacteria pathogens and antibiotic resistance genes for laboratory or research use; Diagnostic apparatus for the detection of virus, bacteria, fungi, protozoa pathogens and antibiotic resistance genes for medical use; Diagnostic kits comprised of diagnostic apparatus for the detection of virus, bacteria, fungi, protozoa pathogens and antibiotic resistance genes for medical use.
(2) Diagnostic reagents and assays for medical, pharmaceutical and veterinary diagnostic use; software for application in the field of diagnostics and for the detection of contaminants (not for medical purposes).
Methods and devices are provided for simultaneously amplifying a plurality of sample wells for a predetermined amount of amplification, detecting whether amplification has occurred in a first set of the wells, amplifying for an additional amount of amplification and detecting whether amplification has occurred in a second set of the wells. Methods are also provided for analyzing a target nucleic acid sequence using melt curves that were generated in a plurality of amplification cycles.
C40B 30/04 - Procédés de criblage des bibliothèques en mesurant l'aptitude spécifique à se lier à une molécule cible, p. ex. liaison anticorps-antigène, liaison récepteur-ligand
C40B 40/00 - Bibliothèques en soi, p. ex. matrices, mélanges
Devices and methods are provided for spotting an array with fluid. Arrays produced by such methods are also provided. In one aspect of the invention, a spotter device for spotting a plurality of fluids into an array is described, the spotter device comprising a plurality of reservoirs provided in a first configuration, each reservoir holding its respective fluid, a print head having a plurality of positions provided in a second configuration, the second configuration being different from the first configuration, a plurality of tubes, each tube configured to provide fluid communication from a reservoir at a first end of the tube to a position in the print head at the second end of the tube, and a pump for pumping fluid through the tubes from the reservoir to the print head.
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyzes include nucleic acid amplification and detection and immuno-PCR.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include high density nucleic acid amplification and detection and immuno-PCR.
In one illustrative embodiment, a cannulated vial is provided, the cannulated vial comprising a vial body having a top surface at one end, a bottom surface at an opposite end, and exterior wall therebetween defining an interior vial volume, the top surface having an opening, a cannula extending from the bottom surface and having a first end, a second end and an outer surface therebetween defining a cannula volume, the first end in fluid communication with the interior vial volume, and a cap having a tongue, the tongue sized to sealably close the opening, the tongue further having a volume greater than or equal to the cannula volume.
A61J 1/05 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques pour recueillir, stocker ou administrer du sang, du plasma ou des liquides à usage médical
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Reagents and assays for scientific research or laboratory use; Reagents and assays for the extraction, amplification, and purification of nucleic acids, for scientific research or laboratory use; Chemical reagents and assays not for medical use, namely, for use in environmental bio-threat detection and pandemic bio-surveillance Medical diagnostic reagents and assays that test for the presence of pathogens and infection; Medical diagnostic kits comprised of medical diagnostic reagents and assays that test for the presence of pathogens and infection; Medical diagnostic reagents and assays that test body fluids for microorganisms; Medical diagnostic kits comprised of medical diagnostic reagents and assays that test body fluids for microorganisms; medical diagnostic reagents for the extraction, amplification, and purification of nucleic acids; Clinical medical reagents and assays for the extraction, amplification, and purification of nucleic acids Kits comprised of laboratory instruments for environmental bio-threat detection and pandemic bio-surveillance as well as reagents and assays; Laboratory equipment, namely, instruments for the detection in biological samples of pathogen targets in the nature of viruses, bacteria, and antibiotic resistance genes; Laboratory equipment, namely, kits comprising instruments for the detection in biological samples of pathogen targets in the nature of viruses, bacteria, and antibiotic resistance genes; Diagnostic apparatus for the detection of virus and bacteria pathogens and antibiotic resistance genes for laboratory or research use; Diagnostic kits comprised of diagnostic apparatus for the detection of virus and bacteria pathogens and antibiotic resistance genes for laboratory or research use Diagnostic apparatus for the detection of virus, bacteria, fungi, protozoa pathogens and antibiotic resistance genes for medical use; Diagnostic kits comprised of diagnostic apparatus for the detection of virus, bacteria, fungi, protozoa pathogens and antibiotic resistance genes for medical use
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
11 - Appareils de contrôle de l'environnement
Produits et services
(1) Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for use in the medical and veterinary fields. Control solutions, control reagents, buffers and diagnostic agents and preparations for clinical, medical, and veterinary use. Laboratory devices, apparatus and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, light emitters such as lasers and light bulbs, lenses, mirrors, stations for placement of microtiter plates, microtiter plate readers; Laboratory materials, articles and disposable, namely, optical filters, computer chips, thermal control elements for heating and cooling, sample containers, transformer connectors, batteries, battery chargers, testing sample pouches, testing sample pouch holders, syringes and plungers, carrying packs specially adapted for carrying all of the above-named goods, plastic or other sampling vials, plastic or other preparation vials; Computer software, computer programs and associated instruction manuals all for use in detecting, identifying, classifying, tagging, labeling, amplifying, testing, analyzing, determining sequence, evaluating, monitoring, purifying, counting, mapping, engineering, expressing, measuring, preparing, testing, mixing, heating and cooling chemical, biochemical, biological, genetic, pathological and toxic agents, pathogens, bacteria, germs, viruses, diseases, contagions, materials and samples; Computer software, computer programs and computer firmware all for use in controlling processes, inputting, analyzing, modifying, transferring, displaying, reporting and storing data and results; Laptop computers, hard drives for computers and computer hardware; Probes for environmental purpose; Analytical instruments, namely, a laboratory instrument combining a rapid air thermocycling apparatus and a fluorimeter; laboratory equipment, namely, units for the purification and amplification of nucleic acids and devices used to heat and cool biological samples; Bio-defense and bio-surveillance systems and instruments, and food and water security testing systems and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling; Scientific apparatus and instruments for measuring DNA, RNA and protein and parts and fittings therefor. Medical apparatus, devices, equipment and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, scanners, microtiter plate readers, stations for placement of microtiter plates, lenses, mirrors, computers, instrument software, analytical software, and cases to hold the foregoing, all for detecting, identifying, classifying, analyzing, evaluating, monitoring, preparing, testing, mixing, heating and cooling nucleic acid, cells, genes and chemical, biochemical, biological, genetic, pathological and toxic materials and samples for medical, clinical and diagnostic purposes; medical materials, articles, apparatus and disposable items, namely, thermal control elements for heating and cooling, containers specially adapted for medical use to hold samples for testing purposes, tubes specially adapted for medical use for testing purposes, microtiter plates, plastic and metal receiver cartridges all for medical, surgical, veterinary, clinical and diagnostic use; Nucleic acid amplifiers for medical use.
(2) Biochemical and chemical reagents used for non-medical purposes for collecting, analyzing, checking and detecting contaminants in food, blood, industrial preparations, or in the environment of such preparations, namely in water, air or work surfaces; diagnostic reagents for scientific or research use, namely diagnostic reagents for collecting, analyzing, checking and detecting contaminants in scientific or research preparations, or in the environment of such preparations, namely in water, air or work surfaces; Freeze-dried reagents for purification of DNA/RNA; Chemical products, namely, reagents, control solutions and control reagents, buffers, dyes and kits comprised of the foregoing, for scientific, research, industrial, quality control and calibration purposes, and for laboratory and field use in the environmental fields for treating environments or for use in testing the condition of environments, testing food, water, blood, air, and other liquids, powders and substances, for use with scientific and research apparatus, and for use in rapid screening, biological processing and assay analysis; Enzymes for industrial use, namely, testing food, water, blood, air, and other liquids, powders and substances; DNA genetic primers, DNA nucleic acid primers, biochemical reagents commonly known as probes, genetic probes and nucleic acid probes for detecting and analyzing molecules in food, water, blood, air, and other liquids, powders and substances; enzymes for environmental diagnostic use, environmental clinical use, environmental laboratory use and for detection of contaminants in industrial settings; Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for scientific or research use in the biological, pathological, genetic, bio-defense and bio-surveillance fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for scientific or research use in the biological, pathological, genetic, environmental, clinical diagnostic, bio-defense and bio-surveillance fields, and for laboratory use.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
11 - Appareils de contrôle de l'environnement
Produits et services
(1) Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for use in the medical and veterinary fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for clinical, medical, and veterinary use; laboratory devices, apparatus and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, light emitters such as lasers and light bulbs, lenses, mirrors, stations for placement of microtiter plates, microtiter plate readers; Laboratory materials, articles and disposable, namely, optical filters, computer chips, thermal control elements for heating and cooling, sample containers, transformer connectors, batteries, battery chargers, testing sample pouches, testing sample pouch holders, syringes and plungers, carrying packs specially adapted for carrying all of the above-named goods, plastic or other sampling vials, plastic or other preparation vials; Computer software, computer programs and associated instruction manuals all for use in detecting, identifying, classifying, tagging, labeling, amplifying, testing, analyzing, determining sequence, evaluating, monitoring, purifying, counting, mapping, engineering, expressing, measuring, preparing, testing, mixing, heating and cooling chemical, biochemical, biological, genetic, pathological and toxic agents, pathogens, bacteria, germs, viruses, diseases, contagions, materials and samples; Computer software, computer programs and computer firmware all for use in controlling processes, inputting, analyzing, modifying, transferring, displaying, reporting and storing data and results; Laptop computers, hard drives for computers and computer hardware; Probes for environmental purpose; Analytical instruments, namely, a laboratory instrument combining a rapid air thermocycling apparatus and a fluorimeter; laboratory equipment, namely, units for the purification and amplification of nucleic acids and devices used to heat and cool biological samples; Bio-defense and bio-surveillance systems and instruments, and food and water security testing systems and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling; Scientific apparatus and instruments for measuring DNA, RNA and protein and parts and fittings therefor; medical apparatus, devices, equipment and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, scanners, microtiter plate readers, stations for placement of microtiter plates, lenses, mirrors, computers, instrument software, analytical software, and cases to hold the foregoing, all for detecting, identifying, classifying, analyzing, evaluating, monitoring, preparing, testing, mixing, heating and cooling nucleic acid, cells, genes and chemical, biochemical, biological, genetic, pathological and toxic materials and samples for medical, clinical and diagnostic purposes; medical materials, articles, apparatus and disposable items, namely, thermal control elements for heating and cooling, containers specially adapted for medical use to hold samples for testing purposes, tubes specially adapted for medical use for testing purposes, microtiter plates, plastic and metal receiver cartridges all for medical, surgical, veterinary, clinical and diagnostic use; Nucleic acid amplifiers for medical use.
(2) Biochemical and chemical reagents used for non-medical purposes for collecting, analyzing, checking and detecting contaminants in food, blood, industrial preparations, or in the environment of such preparations, namely in water, air or work surfaces; diagnostic reagents for scientific or research use, namely diagnostic reagents for collecting, analyzing, checking and detecting contaminants in scientific or research preparations, or in the environment of such preparations, namely in water, air or work surfaces; Freeze-dried reagents for purification of DNA/RNA; Chemical products, namely, reagents, control solutions and control reagents, buffers, dyes and kits comprised of the foregoing, for scientific, research, industrial, quality control and calibration purposes, and for laboratory and field use in the environmental fields for treating environments or for use in testing the condition of environments, testing food, water, blood, air, and other liquids, powders and substances, for use with scientific and research apparatus, and for use in rapid screening, biological processing and assay analysis; Enzymes for industrial use, namely, testing food, water, blood, air, and other liquids, powders and substances; DNA genetic primers, DNA nucleic acid primers, biochemical reagents commonly known as probes, genetic probes and nucleic acid probes for detecting and analyzing molecules in food, water, blood, air, and other liquids, powders and substances; enzymes for environmental diagnostic use, environmental clinical use, environmental laboratory use and for detection of contaminants in industrial settings; Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for scientific or research use in the biological, pathological, genetic, bio-defense and bio-surveillance fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for scientific or research use in the biological, pathological, genetic, environmental, clinical diagnostic, bio-defense and bio-surveillance fields, and for laboratory use.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Biochemical and chemical reagents used for non-medical purposes; Diagnostic reagents for scientific or research use; Freeze-dried reagents for purification of DNA/RNA; Chemical products, namely reagents, control solutions and control reagents, buffers, dyes and kits comprised of the foregoing, for scientific, research, industrial, quality control and calibration purposes, and for laboratory and field use in the environmental fields for treating environments or for use in testing the condition of environments, testing food, water, blood, air, and other liquids, powders and substances, for use with scientific and research apparatus, and for use in rapid screening, biological processing and assay analysis; Enzymes for industrial use, in namely for testing food, water, blood, air, and other liquids, powders and substances; DNA genetic primers, DNA nucleic acid primers, biochemical reagents commonly known as probes, genetic probes and nucleic acid probes for detecting and analyzing molecules in food, water, blood, air, and other liquids, powders and substances; enzymes for environmental diagnostic use, environmental clinical use, environmental laboratory use and industrial use; Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for scientific or research use in the biological, pathological, genetic, bio-defense and bio-surveillance fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for scientific or research use in the biological, pathological, genetic, environmental, clinical diagnostic, bio-defense and bio-surveillance fields, and for laboratory use. Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for use in the medical and veterinary fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for clinical, medical, and veterinary use. Laboratory devices, apparatus and instruments, namely imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, light emitters such as lasers and light bulbs, lenses, mirrors, stations for placement of microtiter plates, microtiter plate readers; Laboratory materials, articles and disposable items, namely optical filters, computer chips, thermal control elements for heating and cooling, sample containers, transformer connectors, batteries, battery chargers, testing sample pouches, testing sample pouch holders, syringes and plungers, carrying packs specially adapted for carrying all of the above-named goods, plastic or other sampling vials, plastic or other preparation vials; Computer software, computer programs and associated instruction manuals all for use in detecting, identifying, classifying, tagging, labeling, amplifying, testing, analyzing, determining sequence, evaluating, monitoring, purifying, counting, mapping, engineering, expressing, measuring, preparing, testing, mixing, heating and cooling chemical, biochemical, biological, genetic, pathological and toxic agents, pathogens, bacteria, germs, viruses, diseases, contagions, materials and samples; Computer software, computer programs and computer firmware all for use in controlling processes, inputting, analyzing, modifying, transferring, displaying, reporting and storing data and results; Laptop computers, hard drives for computers and computer hardware; Probes for environmental purpose; Analytical instruments, in namely a laboratory instrument combining a rapid air thermocycling apparatus and a fluorimeter; laboratory equipment, namely units for the purification and amplification of nucleic acids and devices used to heat and cool biological samples; Bio-defense and bio-surveillance systems and instruments, and food and water security testing systems and instruments, namely imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling; Scientific apparatus and instruments for measuring DNA, RNA and protein and parts and fittings therefor. Medical apparatus, devices, equipment and instruments, namely imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, scanners, microtiter plate readers, stations for placement of microtiter plates, lenses, mirrors, computers, instrument software, analytical software, and cases to hold the foregoing, all for detecting, identifying, classifying, analyzing, evaluating, monitoring, preparing, testing, mixing, heating and cooling nucleic acid, cells, genes and chemical, biochemical, biological, genetic, pathological and toxic materials and samples for medical, clinical and diagnostic purposes; medical materials, articles, apparatus and disposable items, namely thermal control elements for heating and cooling, containers specially adapted for medical use to hold samples for testing purposes, tubes specially adapted for medical use for testing purposes, microtiter plates, plastic and metal receiver cartridges all for medical, surgical, veterinary, clinical and diagnostic use; Nucleic acid amplifiers for medical use. Development of technology for others in the fields of biotechnology and biochemistry; Scientific and laboratory research, design, development, testing, and diagnostics in the fields of biotechnology and biochemistry; Scientific and laboratory sample scanning, product development, software development and maintenance, online information and consulting services.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Biochemical and chemical reagents used for non-medical purposes; Diagnostic reagents for scientific or research use; Freeze-dried reagents for purification of DNA/RNA; Chemical products, namely reagents, control solutions and control reagents, buffers, dyes and kits comprised of the foregoing, for scientific, research, industrial, quality control and calibration purposes, and for laboratory and field use in the environmental fields for treating environments or for use in testing the condition of environments, testing food, water, blood, air, and other liquids, powders and substances, for use with scientific and research apparatus, and for use in rapid screening, biological processing and assay analysis; Enzymes for industrial use, in namely for testing food, water, blood, air, and other liquids, powders and substances; DNA genetic primers, DNA nucleic acid primers, biochemical reagents commonly known as probes, genetic probes and nucleic acid probes for detecting and analyzing molecules in food, water, blood, air, and other liquids, powders and substances; enzymes for environmental diagnostic use, environmental clinical use, environmental laboratory use and industrial use; Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for scientific or research use in the biological, pathological, genetic, bio-defense and bio-surveillance fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for scientific or research use in the biological, pathological, genetic, environmental, clinical diagnostic, bio-defense and bio-surveillance fields, and for laboratory use. Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for use in the medical and veterinary fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for clinical, medical, and veterinary use. Laboratory devices, apparatus and instruments, namely imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, light emitters such as lasers and light bulbs, lenses, mirrors, stations for placement of microtiter plates, microtiter plate readers; Laboratory materials, articles and disposable items, namely optical filters, computer chips, thermal control elements for heating and cooling, sample containers, transformer connectors, batteries, battery chargers, testing sample pouches, testing sample pouch holders, syringes and plungers, carrying packs specially adapted for carrying all of the above-named goods, plastic or other sampling vials, plastic or other preparation vials; Computer software, computer programs and associated instruction manuals all for use in detecting, identifying, classifying, tagging, labeling, amplifying, testing, analyzing, determining sequence, evaluating, monitoring, purifying, counting, mapping, engineering, expressing, measuring, preparing, testing, mixing, heating and cooling chemical, biochemical, biological, genetic, pathological and toxic agents, pathogens, bacteria, germs, viruses, diseases, contagions, materials and samples; Computer software, computer programs and computer firmware all for use in controlling processes, inputting, analyzing, modifying, transferring, displaying, reporting and storing data and results; Laptop computers, hard drives for computers and computer hardware; Probes for environmental purpose; Analytical instruments, in namely a laboratory instrument combining a rapid air thermocycling apparatus and a fluorimeter; laboratory equipment, namely units for the purification and amplification of nucleic acids and devices used to heat and cool biological samples; Bio-defense and bio-surveillance systems and instruments, and food and water security testing systems and instruments, namely imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling; Scientific apparatus and instruments for measuring DNA, RNA and protein and parts and fittings therefor. Medical apparatus, devices, equipment and instruments, namely imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, scanners, microtiter plate readers, stations for placement of microtiter plates, lenses, mirrors, computers, instrument software, analytical software, and cases to hold the foregoing, all for detecting, identifying, classifying, analyzing, evaluating, monitoring, preparing, testing, mixing, heating and cooling nucleic acid, cells, genes and chemical, biochemical, biological, genetic, pathological and toxic materials and samples for medical, clinical and diagnostic purposes; medical materials, articles, apparatus and disposable items, namely thermal control elements for heating and cooling, containers specially adapted for medical use to hold samples for testing purposes, tubes specially adapted for medical use for testing purposes, microtiter plates, plastic and metal receiver cartridges all for medical, surgical, veterinary, clinical and diagnostic use; Nucleic acid amplifiers for medical use. Development of technology for others in the fields of biotechnology and biochemistry; Scientific and laboratory research, design, development, testing, and diagnostics in the fields of biotechnology and biochemistry; Scientific and laboratory sample scanning, product development, software development and maintenance, online information and consulting services.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Laboratory devices, apparatus and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, light emitters such as lasers and light bulbs, lenses, mirrors, stations for placement of microtiter plates, microtiter plate readers; Laboratory materials, articles and disposable, namely, optical filters, computer chips, thermal control elements for heating and cooling, sample containers, transformer connectors, batteries, battery chargers, testing sample pouches, testing sample pouch holders, syringes and plungers, carrying packs specially adapted for carrying all of the above-named goods, plastic or other sampling vials, plastic or other preparation vials; Computer software, computer programs and associated instruction manuals all for use in detecting, identifying, classifying, tagging, labeling, amplifying, testing, analyzing, determining sequence, evaluating, monitoring, purifying, counting, mapping, engineering, expressing, measuring, preparing, testing, mixing, heating and cooling chemical, biochemical, biological, genetic, pathological and toxic agents, pathogens, bacteria, germs, viruses, diseases, contagions, materials and samples; Computer software, computer programs and computer firmware all for use in controlling processes, inputting, analyzing, modifying, transferring, displaying, reporting and storing data and results; Laptop computers, hard drives for computers and computer hardware; Probes for environmental purpose; Analytical instruments, namely, a laboratory instrument combining a rapid thermocycling apparatus and a fluorimeter; laboratory equipment, namely, units for the purification and amplification of nucleic acids and devices used to heat and cool biological samples; Bio-defense and bio-surveillance systems and instruments, and food and water security testing systems and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling; Scientific apparatus and instruments for measuring DNA, RNA and protein and parts and fittings therefor
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Biochemical and chemical reagents used for non-medical purposes; Diagnostic reagents for scientific or research use; Freeze-dried reagents for purification of DNA/RNA; Chemical products, namely, reagents, control solutions and control reagents, buffers, dyes and kits comprised of the foregoing, for scientific, research, industrial, quality control and calibration purposes, and for laboratory and field use in the environmental fields for treating environments or for use in testing the condition of environments, testing food, water, blood, air, and other liquids, powders and substances, for use with scientific and research apparatus, and for use in rapid screening, biological processing and assay analysis; Enzymes for industrial use, namely, testing food, water, blood, air, and other liquids, powders and substances; DNA genetic primers, DNA nucleic acid primers, biochemical reagents commonly known as probes, genetic probes and nucleic acid probes for detecting and analyzing molecules in food, water, blood, air, and other liquids, powders and substances; enzymes for environmental diagnostic use, environmental clinical use, environmental laboratory use and industrial use; Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for scientific or research use in the biological, pathological, genetic, bio-defense and bio-surveillance fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for scientific or research use in the biological, pathological, genetic, environmental, clinical diagnostic, bio-defense and bio-surveillance fields, and for laboratory use Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for use in the medical and veterinary fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for clinical medical, medical, and veterinary use
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Biochemical and chemical reagents used for non-medical purposes; Diagnostic reagents for scientific or research use; Freeze-dried reagents for purification of DNA/RNA; Chemical products, namely, reagents, control solutions and control reagents, buffers, dyes and kits comprised of the foregoing, for scientific, research, industrial, quality control and calibration purposes, and for laboratory and field use in the environmental fields for treating environments or for use in testing the condition of environments, testing food, water, blood, air, and other liquids, powders and substances, for use with scientific and research apparatus, and for use in rapid screening, biological processing and assay analysis; Enzymes for industrial use, namely, testing food, water, blood, air, and other liquids, powders and substances; DNA genetic primers, DNA nucleic acid primers, biochemical reagents commonly known as probes, genetic probes and nucleic acid probes for detecting and analyzing molecules in food, water, blood, air, and other liquids, powders and substances; enzymes for environmental diagnostic use, environmental clinical use, environmental laboratory use and industrial use; Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for scientific or research use in the biological, pathological, genetic, bio-defense and bio-surveillance fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for scientific or research use in the biological, pathological, genetic, environmental, clinical diagnostic, bio-defense and bio-surveillance fields, and for laboratory use Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for use in the medical and veterinary fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for clinical medical, medical, and veterinary use Medical apparatus, devices, equipment and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, scanners, microtiter plate readers, stations for placement of microtiter plates, lenses, mirrors, computers, instrument software, analytical software, and cases to hold the foregoing, all for detecting, identifying, classifying, analyzing, evaluating, monitoring, preparing, testing, mixing, heating and cooling nucleic acid, cells, genes and chemical, biochemical, biological, genetic, pathological and toxic materials and samples for medical, clinical and diagnostic purposes; medical materials, articles, apparatus and disposable items, namely, thermal control elements for heating and cooling, containers specially adapted for medical use to hold samples for testing purposes, tubes specially adapted for medical use for testing purposes, microtiter plates, plastic and metal receiver cartridges all for medical, surgical, veterinary, clinical and diagnostic use; Nucleic acid amplifiers for medical use
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Biochemical and chemical reagents used for non-medical purposes; Diagnostic reagents for scientific or research use; Freeze-dried reagents for purification of DNA/RNA; Chemical products, namely, reagents, control solutions and control reagents, buffers, dyes and kits comprised of the foregoing, for scientific, research, industrial, quality control and calibration purposes, and for laboratory and field use in the environmental fields for treating environments or for use in testing the condition of environments, testing food, water, blood, air, and other liquids, powders and substances, for use with scientific and research apparatus, and for use in rapid screening, biological processing and assay analysis; Enzymes for industrial use, namely, testing food, water, blood, air, and other liquids, powders and substances; DNA genetic primers, DNA nucleic acid primers, biochemical reagents commonly known as probes, genetic probes and nucleic acid probes for detecting and analyzing molecules in food, water, blood, air, and other liquids, powders and substances; enzymes for environmental diagnostic use, environmental clinical use, environmental laboratory use and industrial use; Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for scientific or research use in the biological, pathological, genetic, bio-defense and bio-surveillance fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for scientific or research use in the biological, pathological, genetic, environmental, clinical diagnostic, bio-defense and bio-surveillance fields, and for laboratory use Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for use in the medical and veterinary fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for clinical medical, medical, and veterinary use
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Biochemical and chemical reagents used for non-medical purposes; Diagnostic reagents for scientific or research use; Freeze-dried reagents for purification of DNA/RNA; Chemical products, namely, reagents, control solutions and control reagents, buffers, dyes and kits comprised of the foregoing, for scientific, research, industrial, quality control and calibration purposes, and for laboratory and field use in the environmental fields for treating environments or for use in testing the condition of environments, testing food, water, blood, air, and other liquids, powders and substances, for use with scientific and research apparatus, and for use in rapid screening, biological processing and assay analysis; Enzymes for industrial use, namely, testing food, water, blood, air, and other liquids, powders and substances; DNA genetic primers, DNA nucleic acid primers, biochemical reagents commonly known as probes, genetic probes and nucleic acid probes for detecting and analyzing molecules in food, water, blood, air, and other liquids, powders and substances; enzymes for environmental diagnostic use, environmental clinical use, environmental laboratory use and industrial use; Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for scientific or research use in the biological, pathological, genetic, bio-defense and bio-surveillance fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for scientific or research use in the biological, pathological, genetic, environmental, clinical diagnostic, bio-defense and bio-surveillance fields, and for laboratory use Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for use in the medical and veterinary fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for clinical medical, medical, and veterinary use Medical apparatus, devices, equipment and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, scanners, microtiter plate readers, stations for placement of microtiter plates, lenses, mirrors, computers, instrument software, analytical software, and cases to hold the foregoing, all for detecting, identifying, classifying, analyzing, evaluating, monitoring, preparing, testing, mixing, heating and cooling nucleic acid, cells, genes and chemical, biochemical, biological, genetic, pathological and toxic materials and samples for medical, clinical and diagnostic purposes; medical materials, articles, apparatus and disposable items, namely, thermal control elements for heating and cooling, containers specially adapted for medical use to hold samples for testing purposes, tubes specially adapted for medical use for testing purposes, microtiter plates, plastic and metal receiver cartridges all for medical, surgical, veterinary, clinical and diagnostic use; Nucleic acid amplifiers for medical use
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Biochemical and chemical reagents used for non-medical purposes; Diagnostic reagents for scientific or research use; Freeze-dried reagents for purification of DNA/RNA; Chemical products, namely, reagents, control solutions and control reagents, buffers, dyes and kits comprised of the foregoing, for scientific, research, industrial, quality control and calibration purposes, and for laboratory and field use in the environmental fields for treating environments or for use in testing the condition of environments, testing food, water, blood, air, and other liquids, powders and substances, for use with scientific and research apparatus, and for use in rapid screening, biological processing and assay analysis; Enzymes for industrial use, namely, testing food, water, blood, air, and other liquids, powders and substances; DNA genetic primers, DNA nucleic acid primers, biochemical reagents commonly known as probes, genetic probes and nucleic acid probes for detecting and analyzing molecules in food, water, blood, air, and other liquids, powders and substances; enzymes for environmental diagnostic use, environmental clinical use, environmental laboratory use and industrial use; Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for scientific or research use in the biological, pathological, genetic, bio-defense and bio-surveillance fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for scientific or research use in the biological, pathological, genetic, environmental, clinical diagnostic, bio-defense and bio-surveillance fields, and for laboratory use Diagnostic reagents, buffers, dyes, and kits comprised of the foregoing, for use in the medical and veterinary fields; Control solutions, control reagents, buffers and diagnostic agents and preparations for clinical medical, medical, and veterinary use Medical apparatus, devices, equipment and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, scanners, microtiter plate readers, stations for placement of microtiter plates, lenses, mirrors, computers, instrument software, analytical software, and cases to hold the foregoing, all for detecting, identifying, classifying, analyzing, evaluating, monitoring, preparing, testing, mixing, heating and cooling nucleic acid, cells, genes and chemical, biochemical, biological, genetic, pathological and toxic materials and samples for medical, clinical and diagnostic purposes; medical materials, articles, apparatus and disposable items, namely, thermal control elements for heating and cooling, containers specially adapted for medical use to hold samples for testing purposes, tubes specially adapted for medical use for testing purposes, microtiter plates, plastic and metal receiver cartridges all for medical, surgical, veterinary, clinical and diagnostic use; Nucleic acid amplifiers for medical use
09 - Appareils et instruments scientifiques et électriques
Produits et services
Laboratory devices, apparatus and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, light emitters such as lasers and light bulbs, lenses, mirrors, stations for placement of microtiter plates, microtiter plate readers; Laboratory materials, articles and disposable, namely, optical filters, computer chips, thermal control elements for heating and cooling, sample containers, transformer connectors, batteries, battery chargers, testing sample pouches, testing sample pouch holders, syringes and plungers, carrying packs specially adapted for carrying all of the above-named goods, plastic or other sampling vials, plastic or other preparation vials; Computer software, computer programs and associated instruction manuals all for use in detecting, identifying, classifying, tagging, labeling, amplifying, testing, analyzing, determining sequence, evaluating, monitoring, purifying, counting, mapping, engineering, expressing, measuring, preparing, testing, mixing, heating and cooling chemical, biochemical, biological, genetic, pathological and toxic agents, pathogens, bacteria, germs, viruses, diseases, contagions, materials and samples; Computer software, computer programs and computer firmware all for use in controlling processes, inputting, analyzing, modifying, transferring, displaying, reporting and storing data and results; Laptop computers, hard drives for computers and computer hardware; Probes for environmental purpose; Analytical instruments, namely, a laboratory instrument combining a rapid thermocycling apparatus and a fluorimeter; laboratory equipment, namely, units for the purification and amplification of nucleic acids and devices used to heat and cool biological samples; Bio-defense and bio-surveillance systems and instruments, and food and water security testing systems and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling; Scientific apparatus and instruments for measuring DNA, RNA and protein and parts and fittings therefor
09 - Appareils et instruments scientifiques et électriques
Produits et services
Laboratory devices, apparatus and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling, light emitters such as lasers and light bulbs, lenses, mirrors, stations for placement of microtiter plates, microtiter plate readers; Laboratory materials, articles and disposable, namely, optical filters, computer chips, thermal control elements for heating and cooling, sample containers, transformer connectors, batteries, battery chargers, testing sample pouches, testing sample pouch holders, syringes and plungers, carrying packs specially adapted for carrying all of the above-named goods, plastic or other sampling vials, plastic or other preparation vials; Computer software, computer programs and associated instruction manuals all for use in detecting, identifying, classifying, tagging, labeling, amplifying, testing, analyzing, determining sequence, evaluating, monitoring, purifying, counting, mapping, engineering, expressing, measuring, preparing, testing, mixing, heating and cooling chemical, biochemical, biological, genetic, pathological and toxic agents, pathogens, bacteria, germs, viruses, diseases, contagions, materials and samples; Computer software, computer programs and computer firmware all for use in controlling processes, inputting, analyzing, modifying, transferring, displaying, reporting and storing data and results; Laptop computers, hard drives for computers and computer hardware; Probes for environmental purpose; Analytical instruments, namely, a laboratory instrument combining a rapid thermocycling apparatus and a fluorimeter; laboratory equipment, namely, units for the purification and amplification of nucleic acids and devices used to heat and cool biological samples; Bio-defense and bio-surveillance systems and instruments, and food and water security testing systems and instruments, namely, imaging devices comprising fluorimeters used to record fluorescence signals and produce data, thermal control elements for heating and cooling; Scientific apparatus and instruments for measuring DNA, RNA and protein and parts and fittings therefor
Methods for typing a strain of an organism are provided, the methods comprising the steps of amplifying, in a single reaction mixture containing nucleic acid from the organism, dividing the reaction mixture into a plurality of sets of second-stage reaction wells, each set of second-stage reaction wells containing a different pair of second-stage primers, subjecting each of the second-stage reaction wells to amplification conditions to generate a plurality of second-stage amplicons, melting the second-stage amplicons to generate a melting curve for each second-stage amplicon, and identifying the strain of the organism from the melting curves.
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C07H 21/00 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analysis include nucleic acid amplification and detection and immuno-PCR.
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include high density nucleic acid amplification and detection and immuno-PCR.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
