The present invention relates to: a veterinary pharmaceutical composition, in the form of a palatable tablet, containing a combination of tryptophan, valerian extract and passionflower extract; to the use of the composition for the treatment of noise phobias in companion animals and/or domestic animals, preferably in dogs, more specifically, as well as in rescued wild animals and zoo animals: and to the veterinary pharmaceutical composition in which the pharmaceutically and/or veterinarily acceptable excipients act synergistically to provide a tablet with adequate hardness and low friability.
The present invention relates to: a veterinary pharmaceutical composition, in the form of a palatable tablet, containing a combination of tryptophan, valerian extract and passion flower extract; to the use of the composition for the treatment of noise phobias in companion animals and/or domestic animals, preferably in dogs, more specifically, as well as in rescued wild animals and zoo animals; and to a veterinary pharmaceutical composition in which the pharmaceutically and/or veterinarily acceptable excipients act synergistically to provide a tablet with adequate hardness and low friability.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
Produits et services
Cosmetic preparations; cosmetic products for skincare, namely, facial cleaning preparations, acne foam cleansers and moisturizers, not for medical purposes; non-medicated facial soaps; toilet products, namely, moisturizing preparations for the skin; cosmetic pencils; tissues impregnated with cosmetic lotions; bath preparations, not for medical purposes; lotions for cosmetic purposes
7.
STEREOISOMERS OF THE COMPOUND 3-(BENZO[D][1,3]DIOXOL-5-YL)-7-(1-HYDROXYPROPAN-2-YL)-1-(1H-INDOL-3-YL)-6,7-DIHYDRO-3H-OXAZOL[3,4-A]PYRAZINE-5,8-DIONE AND USE THEREOF AS AN ANTITUMOR AGENT AND PHOSPHODIESTERASE ENZYME INHIBITOR
The present invention relates to the compounds 3 -(benzo[d][1,3]dioxol-5-yl)-7-(1-hydroxypropan-2-yl)-1-(1H -indol-3-yl)-6,7-dihydro-3H-oxazol[3,4-a]pyrazine-5,8-dione of formula (I)),
The present invention relates to the compounds 3 -(benzo[d][1,3]dioxol-5-yl)-7-(1-hydroxypropan-2-yl)-1-(1H -indol-3-yl)-6,7-dihydro-3H-oxazol[3,4-a]pyrazine-5,8-dione of formula (I)),
The present invention relates to the compounds 3 -(benzo[d][1,3]dioxol-5-yl)-7-(1-hydroxypropan-2-yl)-1-(1H -indol-3-yl)-6,7-dihydro-3H-oxazol[3,4-a]pyrazine-5,8-dione of formula (I)),
and also to pharmaceutically acceptable stereoisomers, salts, solvates, hydrates, prodrugs and esters thereof; the stereoisomers being in their separate individual forms and/or in the forms of racemic mixtures or non-racemic mixtures with diastereomeric excess in any proportions, a pharmaceutical composition comprising at least one of the compounds described; the use of said stereoisomers as an antitumor agent or phosphodiesterase enzyme inhibitor, and the use of said stereoisomers in the treatment of benign prostatic hyperplasia and cancer, more specifically prostate cancer.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Cosmetic preparations; cosmetic products for skincare, namely, facial cleaning preparations, acne foam cleansers and facial moisturizers, not for medical purposes; cosmetic preparations for sun protection; hair lotions; preparations for nail care; facial soaps being skin soap; toilet products, namely, moisturizing preparations for the skin Medicines for human and veterinary use, namely, pharmaceutical and veterinary pharmaceutical preparations for in the treatment of disorders of the nervous system, the immune system, the cardiovascular system, the metabolic system, the respiratory system, the musculoskeletal system, and the genitourinary system for the treatment of inflammatory disorders and for use in dermatology, antifungal, oncology, hematology and in tissue and organ transplantation, in ophthalmology and for gastroenterological disorders; adjuvants for medical purposes; pharmaceutical preparations for human and veterinary use for the treatment and prevention of disorders of the nervous system, the immune system, the cardiovascular system, the metabolic system, the respiratory system, the musculoskeletal system, and the genitourinary system for the treatment of inflammatory disorders and for use in dermatology, antifungal, oncology, hematology and in tissue and organ transplantation, in ophthalmology and for gastroenterological disorders; chemical-pharmaceutical preparations for the treatment of disorders of the nervous system, the immune system, the cardio-vascular system, the metabolic system, the respiratory system, the musculoskeletal system, and the genitourinary system for the treatment of inflammatory disorders and for use in dermatology, antifungal, oncology, hematology and in tissue and organ transplantation, in ophthalmology and for gastroenterological disorders; nutritional complements in the nature of nutritional supplements; mineral food supplements; vitamins and mineral supplements; dietetic food, namely, cereals, powdered milk for babies, salt, and sugar adapted for medical use
9.
STEREOISOMERS OF THE COMPOUND 3-(BENZO[D][1,3]DIOXOL-5-YL)-7-(1-HYDROXYPROPAN-2-YL)-1-(1H-INDOL-3-YL)-6,7-DIHYDRO-3H-OXAZOL[3,4-A]PYRAZINE-5,8-DIONE AND USE THEREOF AS AN ANTITUMORAGENT AND PHOSPHODIESTERASE ENZYME INHIBITOR
The present invention relates to the compound 3-(benzo[d][1,3]dioxol-5-yl)-7-(1-hydroxypropan-2-yl)-1-(1H-indol-3-yl)-6,7-dihydro-3H-oxazol[3,4-a]pyrazine-5,8-dione of formula (I), and also to pharmaceutically acceptable stereoisomers, salts, solvates, hydrates, prodrugs and esters thereof, the stereoisomers being in their separate individual forms and/or in the form of racemic mixtures or non-racemic mixtures with diastereomeric excess in any proportion; to a pharmaceutical composition comprising at least one of the compounds described; to the use of said stereoisomers as an antitumour agent or phosphodiesterase enzyme inhibitor; and to the use of said stereoisomers for treating benign prostatic hyperplasia and cancer, more specifically prostate cancer.
The present invention relates to the compound 3-(benzo[d][1,3]dioxol-5-yl)-7-(1-hydroxypropan-2-yl)-1-(1H-indol-3-yl)-6,7-dihydro-3H-oxazol[3,4-a]pyrazine-5,8-dione of formula (I), and also to pharmaceutically acceptable stereoisomers, salts, solvates, hydrates, prodrugs and esters thereof, the stereoisomers being in their separate individual forms and/or in the form of racemic mixtures or non-racemic mixtures with diastereomeric excess in any proportion; to a pharmaceutical composition comprising at least one of the compounds described; to the use of said stereoisomers as an antitumour agent or phosphodiesterase enzyme inhibitor; and to the use of said stereoisomers for treating benign prostatic hyperplasia and cancer, more specifically prostate cancer.
The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I):
or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
Produits et services
(1) Cosmetic preparations, namely, cosmetics and make-up; cosmetic products for skincare; facial soaps; toilet products, namely, moisturizing preparations for the skin; cosmetic pencils; bath preparations, not for medical purposes, namely, non-medicated bubble bath preparations
13.
Dermocosmetic composition, production process of the topical composition, method for strengthening fragile nails and use of the composition
The present invention relates to a dermocosmetic composition comprising natural substances for topical use, to improve the appearance, protection and strengthening of nails as well as assisting in the recovery of nail disorders. Additionally, the present invention also relates to a process for preparing said composition, a method for strengthening of fragile nails, and the use of this composition in the preparation of a topical composition for the treatment of nail disorders.
The present invention relates to a dermocosmetic composition comprising natural substances for topical use, to improve the appearance, protection and strengthening of nails as well as assisting in the recovery of nail disorders. Additionally, the present invention also relates to a process for preparing said composition, a method for strengthening of fragile nails, and the use of this composition in the preparation of a topical composition for the treatment of nail disorders.
The present invention relates to a dermocosmetic composition comprising natural substances for topical use, to improve the appearance, protection and strengthening of nails as well as assisting in the recovery of nail disorders. Additionally, the present invention also relates to a process for preparing said composition, a method for strengthening of fragile nails, and the use of this composition in the preparation of a topical composition for the treatment of nail disorders.
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
UNIVERSIDADE FEDERAL DO RlO GRANDE DO SUL-UFRGS (Brésil)
Inventeur(s)
Pohlmann, Adriana Raffin
Guterres, Silvia Stanisçuaski
Jäger, Alessandro
Abrégé
The present invention describes cosmetic nanotechnology, comprising polymeric nanoparticles containing oil and UV filter, photoprotective compositions comprising polymeric nanoparticles described herein, methods of prevention of diseases of the skin, and processes for the preparation of the polymeric nanoparticles described herein.
A61K 8/40 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant de l'azote
A61K 8/92 - Huiles, graisses ou ciresLeurs dérivés, p. ex. produits d'hydrogénation
A61Q 17/04 - Préparations topiques pour faire écran au soleil ou aux radiationsPréparations topiques pour bronzer
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 8/84 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons insaturées carbone-carbone
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
Produits et services
(1) Cosmetics all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust, calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; cosmetic products for skincare, namely, cosmetic creams for skin care, skin care preparations all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust, calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; preparations for sun protection, namely, cosmetics for sun protection, sunscreen preparations all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools. spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust, calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; hair lotions all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; nail care preparations all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; soaps, namely, antibacterial soap, liquid soap, hand soap all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; toilet products, namely, soaps for toilet purposes, impregnated cleaning pads impregnated with toilet preparations all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; dentifrices all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use
(2) Medicines for human and veterinarian use, namely, antifungal creams for medical use, vaginal antifungal preparations, folic acid, antiallergic medicines, medicines for the treatment of gastrointestinal diseases, intestinal disorder medicines for the treatment of diverticular disease, fertility enhancement preparations for animal use, pharmaceutical products for skin care for animals all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; pharmaceutical preparations for the relief of pain all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; pharmaceutical preparations for human and veterinarian use, namely, pharmaceutical preparations for the treatment of diseases, disorders and infections of the endocrine system, namely growth and thyroid disorders, pharmaceutical preparations for the treatment of inflammatory muscle diseases and disorders, pharmaceutical preparations for the treatment of oncological diseases and disorders, pharmaceutical preparations for the treatment of ophthalmological diseases and disorders, pharmaceutical preparations for the treatment of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, pharmaceutical preparations for the treatment of the musculoskeletal system, namely, connective tissue diseases, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries, pharmaceutical preparations for the treatment of the respiratory system, pharmaceutical preparations for the treatment of gastro-intestinal diseases, pharmaceutical preparations for the treatment of genito-urinary and pelvic diseases, disorders and infections, namely infertility, sexually transmitted diseases, incontinence and sexual dysfunction, pharmaceutical preparations for the treatment of blood disorders, pharmaceutical preparations for use in dermatology, namely, dermatitis, skin pigmentation diseases, sexually transmitted diseases, pharmaceutical preparations for the treatment of cardiovascular diseases, pharmaceutical preparations for the relief of pain, pharmaceutical preparations for animal skincare all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; nutritional complements, namely, vitamins, nutritional supplements for general health and well-being, fodder additives for medical purposes, non-medical nutritional additives for animal foodstuffs, protein supplements for animals, animal feed supplements, pet food additives in the form of vitamins and minerals all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; mineral food supplements all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; vitamins and minerals all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; dietetic food adapted for medical use, namely, dietary fibre as a food additive, infant foods, milk sugar for lactose intolerance, powdered milk for babies, mineral salts for medical purposes, dietetic sugar for medical use all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use (1) Commercialization of cosmetics and pharmaceutical products, namely, research of pharmaceutical products and cosmetics, development of pharmaceutical products and cosmetics, distribution of pharmaceutical products and cosmetics, sales of pharmaceutical products and cosmetics all of the foregoing services excluding any services in the field of pool and spa care and water treatment
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
Produits et services
(1) Cosmetics all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust, calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; cosmetic products for skincare, namely, cosmetic creams for skin care, skin care preparations all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust, calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; preparations for sun protection, namely, cosmetics for sun protection, sunscreen preparations all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools. spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust, calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; hair lotions all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; nail care preparations all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; soaps, namely, antibacterial soap, liquid soap, hand soap all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; toilet products, namely, soaps for toilet purposes, impregnated cleaning pads impregnated with toilet preparations all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; dentifrices all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use
(2) Medicines for human and veterinarian use, namely, antifungal creams for medical use, vaginal antifungal preparations, folic acid, antiallergic medicines, medicines for the treatment of gastrointestinal diseases, intestinal disorder medicines for the treatment of diverticular disease, fertility enhancement preparations for animal use, pharmaceutical products for skin care for animals all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; pharmaceutical preparations for the relief of pain all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; pharmaceutical preparations for human and veterinarian use, namely, pharmaceutical preparations for the treatment of diseases, disorders and infections of the endocrine system, namely growth and thyroid disorders, pharmaceutical preparations for the treatment of inflammatory muscle diseases and disorders, pharmaceutical preparations for the treatment of oncological diseases and disorders, pharmaceutical preparations for the treatment of ophthalmological diseases and disorders, pharmaceutical preparations for the treatment of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, pharmaceutical preparations for the treatment of the musculoskeletal system, namely, connective tissue diseases, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries, pharmaceutical preparations for the treatment of the respiratory system, pharmaceutical preparations for the treatment of gastro-intestinal diseases, pharmaceutical preparations for the treatment of genito-urinary and pelvic diseases, disorders and infections, namely infertility, sexually transmitted diseases, incontinence and sexual dysfunction, pharmaceutical preparations for the treatment of blood disorders, pharmaceutical preparations for use in dermatology, namely, dermatitis, skin pigmentation diseases, sexually transmitted diseases, pharmaceutical preparations for the treatment of cardiovascular diseases, pharmaceutical preparations for the relief of pain, pharmaceutical preparations for animal skincare all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; nutritional complements, namely, vitamins, nutritional supplements for general health and well-being, fodder additives for medical purposes, non-medical nutritional additives for animal foodstuffs, protein supplements for animals, animal feed supplements, pet food additives in the form of vitamins and minerals all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; mineral food supplements all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; vitamins and minerals all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use; dietetic food adapted for medical use, namely, dietary fibre as a food additive, infant foods, milk sugar for lactose intolerance, powdered milk for babies, mineral salts for medical purposes, dietetic sugar for medical use all of the foregoing excluding chemicals and cleaning products for cleaning or treating swimming pools, spas and other water, and chemicals used to manufacture household cleaning products, namely, toilet bowl cleaners, drain openers, tub and shower cleaners, rust. calcium, and lime removing preparations, stain removing preparations, multi-purpose cleaners, and degreasing preparations, for indoor and outdoor use (1) Commercialization of cosmetics and pharmaceutical products, namely, research of pharmaceutical products and cosmetics, development of pharmaceutical products and cosmetics, distribution of pharmaceutical products and cosmetics, sales of pharmaceutical products and cosmetics all of the foregoing services excluding any services in the field of pool and spa care and water treatment
The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): General Formula (I) or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.
The present invention relates to derivatives of 6,7-dihydro- 3H-oxazolo[3,4-a]pyrazine-5,8-dione, or to a mixture thereof. The present invention also encompasses the pharmaceutical compositions comprising an effective amount of one of said compounds of the presentinvention, as well as to the use of said compounds and/or derivatives as a phosphodiesterase enzyme inhibitor, and the use of the compounds and/or derivatives in the treatment of erectile dysfunction, disorders and/or conditions treatable with relaxation of tissues and disorders treatable with phosphodiesterase inhibitors, more particularly PDE-5 inhibitor. A further objective of the present invention is to provide a medication comprising a therapeutically effective amount of said compound and a method of treatment using the said compounds.
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61P 15/10 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour l'impuissance
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
21.
Substituted oxazolo[3,4-a]pyrazines as pharmaceutcals
The present invention relates to novel derivatives of 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione represented by formula (I):
and a mixture of these derivatives. The present invention also encompasses the pharmaceutical compositions comprising an effective amount of a said compounds, object of the present invention, as well as to the use of the compounds and/or derivatives as a phosphodiesterase enzyme inhibitor, and the use of the compounds and/or derivatives in the treatment of erectile dysfunction, disorders and/or conditions treatable with relaxation of tissues and disorders treatable with phosphodiesterase inhibitors, more particularly PDE-5 inhibitor. A further objective of the present invention is to provide a medication comprising a therapeutically effective amount of said compound and a method of treating using the said novel compounds.
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
C07D 241/38 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné condensés avec des carbocycles ou avec des systèmes carbocycliques avec uniquement des atomes d'hydrogène ou de carbone liés directement aux atomes d'azote du cycle
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
The present invention relates to novel 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione derivatives or to a mixture thereof. The present invention also relates to pharmaceutical compositions comprising an effective quantity of one of said novel compounds of the invention, as well as to the use of said compounds and/or derivatives as inhibitors of phosphodiesterase enzymes, and to the use of the compounds and/or derivatives for the treatment of erectile dysfunction, disorders and/or conditions which can be treated with tissue relaxants and disorders which can be treated with phosphodiesterase inhibitors, more specifically with PDE-5 inhibitors. Another aim of the present invention is to provide a medicinal drug comprising a therapeutically effective quantity of one of the novel compounds and a method of treatment using novel compounds.
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61P 15/10 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour l'impuissance
23.
Finasteride polymeric nanoparticle, aqueous suspension containing the same, composition for the treatment of alopecia, process of preparation of said composition, and its use
Unidersidade Federal Do Rio Grande Do Sul—UFRGS (Brésil)
Inventeur(s)
Pohlmann, Adriana Raffin
Jornada, Denise Duarte
Guterres, Silva Staniscuaski
Abrégé
The present invention aims to provide a pharmaceutical composition for the treatment of alopecia, said composition comprising polymeric nanoparticles, preferably nanocapsules, containing finasteride, additives and a pharmaceutically acceptable carrier, as well as the use of the nanoparticles for preparing said composition for treating alopecia. The invention further includes an appropriate finasteride nanocapsule preparation process suitable for a composition for topical application for treating alopecia.
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61Q 7/00 - Préparations pour modifier la pousse des cheveux ou des poils
A61K 8/02 - Cosmétiques ou préparations similaires pour la toilette caractérisés par une forme physique particulière
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
24.
Finasteride and minoxidil polymeric nanoparticle its process of preparation, aqueous suspension containing the same, pharmaceutical composition, and its use
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL—UFRGS (Brésil)
Inventeur(s)
Pohlmann, Adriana Raffin
Jornada, Denise Soledade
Nascimento, Ludmila Pinheiro Do
Guterres, Silvia Staniscuaski
Abrégé
The present invention relates to a pharmaceutical composition for topical application for the treatment of alopecia, said composition comprising polymeric nanoparticles, preferably nanocapsules containing two active ingredients, finasteride and minoxidil, additives and a pharmaceutically acceptable carrier. The invention further includes a process for the preparation of polymeric nanoparticles, preferably nanocapsules of finasteride and minoxidil, a composition suitable for topical application for the treatment of alopecia, as well as the use of said nanocapsules for the preparation of a pharmaceutical composition.
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/58 - Revêtements organiques contenant des polymères synthétiques solides
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Anaesthetics.
27.
POLYMERIC FINASTERIDE NANOPARTICLE, AQUEOUS COMPOSITION CONTAINING SAME, COMPOSITION FOR THE TREATMENT OF ALOPECIA, METHOD FOR PREPARING SAID COMPOSITION, AND USE THEREOF
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - UFRGS (Brésil)
Inventeur(s)
Pohlmann, Adriana Raffin
Jornada, Denise Soledade
Guterres, Silvia Staniscuaski
Abrégé
The present invention aims at providing a pharmaceutical composition for the treatment of alopecia, the composition comprising polymeric nanoparticles, preferably nanocapsules, that contain finasteride, pharmaceutically acceptable additives and carriers, and also relates to the use of the nanoparticles for preparing the composition for the treatment of alopecia. The invention further includes a method for preparing finasteride nanocapsules suitable for a composition for topical application for the treatment of alopecia.
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61P 17/14 - Médicaments pour le traitement des troubles dermatologiques pour le traitement de la calvitie ou de l'alopécie
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
28.
POLYMERIC FINASTERIDE AND MINOXIDIL NANOPARTICLES, METHOD FOR PREPARING SAME, AQUEOUS SUSPENSION CONTAINING SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - UFRGS (Brésil)
Inventeur(s)
Pohlmann, Adriana Raffin
Jornada, Denise Soledade
Nascimento, Ludmila Pinheiro Do
Guterres, Silvia Staniscuaski
Abrégé
The present invention relates to a pharmaceutical composition of topical application for the treatment of alopecia, the composition comprising polymeric nanoparticles, preferably nanocapsules, containing two active principles, finasteride and minoxidil, and pharmaceutically acceptable additives and carriers. The invention further includes a method for preparing polymeric finasteride and minoxidil nanoparticles, preferably nanocapsules, suitable for a composition of topical application for the treatment of alopecia, as well as the use of said nanocapsules for preparing a pharmaceutical composition.
A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61P 17/14 - Médicaments pour le traitement des troubles dermatologiques pour le traitement de la calvitie ou de l'alopécie
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
29.
POLYMERIC FINASTERIDE NANOPARTICLE, AQUEOUS COMPOSITION CONTAINING SAME, COMPOSITION FOR THE TREATMENT OF ALOPECIA, METHOD FOR PREPARING SAID COMPOSITION, AND USE THEREOF
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - UFRGS (Brésil)
Inventeur(s)
Pohlmann, Adrian Raffin
Jornada, Denise Duarte
Guterres, Silva Stanisçuaski
Abrégé
The present invention aims at providing a pharmaceutical composition for the treatment of alopecia, the composition comprising polymeric nanoparticles, preferably nanocapsules, that contain finasteride, pharmaceutically acceptable additives and carriers, and also relates to the use of the nanoparticles for preparing the composition for the treatment of alopecia. The invention further includes a method for preparing finasteride nanocapsules suitable for a composition for topical application for the treatment of alopecia.
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61P 17/14 - Médicaments pour le traitement des troubles dermatologiques pour le traitement de la calvitie ou de l'alopécie
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
30.
POLYMERIC FINASTERIDE AND MINOXIDIL NANOPARTICLES, METHOD FOR PREPARING SAME, AQUEOUS SUSPENSION CONTAINING SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - UFRGS (Brésil)
Inventeur(s)
Pohlmann, Adriana Raffin
Jornada, Denise Soledade
Nascimento, Ludmila Pinheiro Do
Guterres, Silvia Stanisçuaski
Abrégé
The present invention relates to a pharmaceutical composition of topical application for the treatment of alopecia, the composition comprising polymeric nanoparticles, preferably nanocapsules, containing two active principles, finasteride and minoxidil, and pharmaceutically acceptable additives and carriers. The invention further includes a method for preparing polymeric finasteride and minoxidil nanoparticles, preferably nanocapsules, suitable for a composition of topical application for the treatment of alopecia, as well as the use of said nanocapsules for preparing a pharmaceutical composition.
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
A61P 17/14 - Médicaments pour le traitement des troubles dermatologiques pour le traitement de la calvitie ou de l'alopécie
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
31.
A TOPICAL PHARMACEUTICAL COMPOSITION, PROCESS OF PRODUCING TOPICAL PHARMACEUTICAL COMPOSITION, USE OF TOPICAL PHARMACEUTICAL COMPOSITION AND METHOD FOR TOPICAL TREATMENT OF PSORIASIS, ATOPIC DERMATITIS OR CHRONIC ECZEMA
A topical pharmaceutical composition comprising a combination of methotrexate, alpha bisabolol and allantoin; a process for producing the same and the use of the composition in the treatment of plague psoriasis (psoriasis vulgaris), atopic dermatitis and chronic eczema. The composition of this invention can be used alone or in combination with other topical or systemic therapies. The present invention further discloses a process for producing the pharmaceutical composition.
TOPICAL PHARMACEUTICAL COMPOSITION, METHOD FOR PRODUCING THE TOPICAL PHARMACEUTICAL COMPOSITION, USE OF THE TOPICAL PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TOPICAL TREATMENT OF PSORIASIS, ATOPIC DERMATITIS OR CHRONIC ECZEMA
The present invention relates to a topical pharmaceutical composition comprising the combination of methotrexate, alpha-bisabolol and allantoin; to the method for producing same and to the use of the composition for treating plaque psoriasis (common psoriasis), atopic dermatitis and chronic eczema. The composition according to the present invention can be used in isolation or in association with other systemic or topical therapies. The present invention also describes a process for producing the pharmaceutical composition.
4 are defined herein, processes for the preparation of said compounds, pharmaceutical compositions containing them, as well as uses as inhibitors of the enzyme phosphodiesterase type 5 (PDE-5) in the treatment of the erectile dysfunction and PDE-5 inhibitor treatable disorders.
The present invention describes a series of derivatives of 6, 7-dihydro-3H-oxazolo [3, 4-a] pyrazine-5, 8-dione, mixtures thereof, their pharmaceutically acceptable salts, which are inhibitors of PDE-5, possessing vasodilatator properties and relaxing effects. In particular, the derivative (J¾)-3-(l,3- benzodioxol-5-yl ) -1- ( lH-indol-3-yl ) -7-methyl-6, 7- dihydro [1, 3] oxazolo [3, 4-a] pyrazine-5, 8-dione, its enantiomer (S) -3- (1, 3-benzodioxol-5-yl) -1- ( lH-indol-3-yl ) -7-methyl-6, 7- dihydro [1,3] oxazolo [3, 4-a] pyrazine-5, 8-dione. The present invention describes, additionally, processes for the preparation of said compounds, pharmaceutical compositions containing them, as well as uses as inhibitors of the enzyme phosphodiesterase type 5 (PDE-5) in the treatment of the erectile dysfunction and PDE-5 inhibitor treatable disorders.
The present invention describes a series of derivatives of 6, 7-dihydro -3H- oxazolo [3,4-a] pyrazine-5,8-dione, mixtures thereof, their pharmaceutically acceptable salts, which are inhibitors of PDE-5, possessing vasodilatator properties and relaxing effects. In particular, the derivative (R)-3-(1,3-benzodioxol-5-yl) -1- (1H-indol-3-yl) -7-methyl-6, 7-dihydro [1,3] oxazolo [3,4-a] pyrazine-5,8-dione, its enantiomer (S)-3-(1,3-benzodioxol-5-yl) -1- (1H-indol-3-yl) -7-methyl-6, 7-dihydro [1,3] oxazolo [3,4-a] pyrazine-5,8-dione. The present invention describes, additionally, processes for the preparation of said compounds, pharmaceutical compositions containing them, as well as uses as inhibitors of the enzyme phosphodiesterase type 5 (PDE-5) in the treatment of the erectile dysfunction and PDE-5 inhibitor treatable disorders.(see formula I)
BENZYL ARALKYL ETHER COMPOUNDS, METHOD FOR PREPARING SAME, INTERMEDIATE COMPOUNDS, USE OF SAID COMPOUNDS, METHOD FOR TREATMENT AND/OR PREVENTION, PHARMACEUTICAL COMPOSITION AND MEDICAMENT CONTAINING SAME
The present invention describes new anti-fungal, benzyl aralkyl ether compounds of formula (I), where: Ar stands for aryl, imidazolyl, 1,2,4-triazolyl, benzimidazolyl; R1, R2, R4 and R5 independently stand for hydrogen, halogen, C1-6 alkyl; R3 stands for halogen, C1-6 alkyl or O-R', where R' stands for hydrogen or lower alkyls; R6 stands for aryl, substituted aryl, trifluoromethyl, trichloromethyl or O-R', where R' stands for hydrogen or lower alkyls, the aryl substituents being a halogen or a tetrazolyl radical; n and m independently equal an integer from 0 to 5, provided that, when Ar stands for imidazolyl, R3 for chlorine, R6 for p-phenyl and R1, R2, R4 and R5 for hydrogen, n is different from 2. When n and m differ from 0 and 1, R3 or R6 may represent optionally different substituents. The present invention also relates to the pharmaceutically acceptable salts, solvates, pro-drugs, esters, enantiomers and/or diastereoisomers thereof, or mixtures thereof, to the methods for preparing said compounds, to intermediate compounds, to pharmaceutical compositions comprising said compounds and/or derivatives, to medicaments comprising said compounds and/or derivatives, as well as to the uses of and methods using said compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by micro-organisms such as fungi, bacteria and/or protozoa, for inhibiting the proliferation and/or survival of said micro-organisms, for treating and/or preventing micro-organism growth on an individual, and for producing a medicament.
C07D 233/56 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle
C07D 257/06 - Cycles à cinq chaînons avec des atomes d'azote liés directement à l'atome de carbone du cycle
A61K 31/4174 - Arylalkylimidazoles, p. ex. oxymétazoline, naphazoline, miconazole
A61P 33/02 - Antiprotozoaires, p. ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose
37.
ARALKYL BENZYL ETHERS COMPOUNDS, PROCESS FOR PREPARATION THEREOF, INTERMEDIATE COMPOUNDS, USE OF SUCH COMPOUNDS, METHODS OF TREATMENT AND/OR PREVENTION, PHARMACEUTICAL COMPOSITIONAND MEDICINE CONTAINING THE SAME
This invention describes new antifungal compounds that are aralkyl benzyl ethers of the formula (I):(see formula I)wherein: Ar is imidazolyl;R1, R2, R4 and R5 are independently hydrogen;R3 is halogen;R6 is trifluoromethyl or trichloromethyl ;n is an integer from 0 to 2; andm is 1;This invention also refers to their salts, solvates, esters, enantiomers and/or pharmaceutically acceptable diastereoisomers, or mixtures thereof, processes for the preparation of these compounds, intermediate compounds, pharmaceutical compositions comprising such compounds and/or derivatives, including those compounds and/or derivatives, as well as the uses and methods of these compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by microorganisms such as fungi, bacteria and/or protozoa, for the inhibition of proliferation and/or survival of said microorganisms, for the treatment and/or prevention of colonization of microorganisms in an individual, and for the manufacture of a medicine.
A61P 33/02 - Antiprotozoaires, p. ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose
C07C 15/14 - Hydrocarbures polycycliques non condensés tous les groupes phényle étant directement liés
C07D 233/56 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle
C07D 257/06 - Cycles à cinq chaînons avec des atomes d'azote liés directement à l'atome de carbone du cycle
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and veterinary preparations; Hygienic preparations for medical purposes; Dietetic substances adapted for medical use, food for babies; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - UFRGS (Brésil)
Inventeur(s)
Pohlmann, Adriana Raffin
Guterres, Sílvia Stanisçuaski
Jäger, Alessandro
Abrégé
The present invention describes cosmetic nanotechnology, comprising polymeric nanoparticles containing oil and UV filter, photoprotective compositions comprising polymeric nanoparticles described herein, methods of prevention of diseases of the skin, and processes for the preparation of the polymeric nanoparticles described herein.
Universidade Federal Do Rio Grande Do Sul (Brésil)
Inventeur(s)
Junior, Dante Alário
Guterres, Silvia Stanisçuski
Pohlmann, Adriana Raffin
Zancan, Lali Rosoni
Abrégé
The present invention relates to a nanoparticulated anaesthetic composition for topical use in which at least one local anaesthetic agent is encapsulated in polymeric nanoparticles. The present invention also relates to the use of such polymeric nanoparticles comprising at least one local anaesthetic agent in the preparation of an anaesthetic composition for topical application to the skin or mucosa.
The present invention describes a series of derivatives of 2-(3-methylenedioxy)-benzoyl indol, their mixtures, their pharmaceutically acceptable salts, their enantiomers, pharmaceutical compositions comprising them, processes for preparing them, use in the prophylactic and/or curative treatment of sexual dysfunction. More specifically, the invention describes derivatives (R)-3-((2-(benzo[d][1,3]dioxol-5-carbonyl)-1H-indol-3-yl)methyl)-1-methylpiperazine-2,5-dione, and S)-3-((2-(benzo[d][1,3]dioxol-5-carbonyl)-1H-indol-3-yl)methyl)-1-methylpiperazine-2,5-dione.
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 209/12 - Radicaux substitués par des atomes d'oxygène
C07D 209/14 - Radicaux substitués par des atomes d'azote ne faisant pas partie d'un radical nitro
C07D 241/08 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant une ou deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des atomes d'oxygène liés directement aux atomes de carbone du cycle
C07D 317/50 - Méthylènedioxybenzènes ou méthylènedioxybenzènes hydrogénés, non substitués sur l'hétérocycle avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes du carbocycle
43.
PHARMACEUTICAL COMPOSITION COMPRISING RACETAM AND CARNITINE AND PROCESS FOR ITS PREPARATION
The present invention refers to a pharmaceutical composition comprising racetam and carnitine. Said pharmaceutical composition may further comprise coenzyme QlO and/or agent associated with mitochondrial and/or metabolic disturbance,such as hypocholesterolemic agent of the statins group, a hypoglycemic agent, or an antiepileptic agent. The invention also includes a method of treatment for mitochondrial disturbances comprising administration of the pharmaceutical composition of the invention.
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
A61K 31/205 - Sels d'addition d'acides organiques avec des aminesSels d'ammonium quaternaire internes, p. ex. bétaïne, carnitine
A61K 31/20 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique
Universidade Federal do Rio Grande do Sul - UFRGS (Brésil)
Inventeur(s)
Junior, Dante Alário
Guterres, Silvia Stanisçuaski
Pohlmann, Adriana Raffin
Zancan, Lali Ronsoni
Abrégé
The present invention relates to a nanoparticulated anaesthetic composition for topical use in which at least one local anaesthetic agent is encapsulated in polymeric nanoparticles. The present invention also relates to the use of such polymeric nanoparticles comprising at least one local anaesthetic agent in the preparation of an anaesthetic composition for topical application to the skin or mucosa.
A61K 31/166 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome de carbone d'un groupe carboxamide lié directement au cycle aromatique, p. ex. procaïnamide, procarbazine, métoclopramide, labétalol
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61K 47/30 - Composés macromoléculaires organiques ou inorganiques, p. ex. polyphosphates inorganiques
47.
PHARMACEUTICAL COMPOSITION COMPRISING TRAMADOL AND KETOPROFEN
The present invention relates to a pharmaceutical composition comprising a combination of active principles. More specifically: a stable pharmaceutical composition comprising a combination of tramadol and ketoprofen. Furthermore, a combination in solid form in which the active principles are vehicled in pharmaceutical forms and/or products that prevent contact between them. Complementarily, the present invention also relates to the combined use of ketoprofen and tramadol in the preparation of an oral medicine useful for relieving pain as well as a method for relieving pain with an oral pharmaceutical composition comprising a combination of tramadol and ketoprofen.
UNIVERSIDADE FEDERAL DE MINAS GERAIS - UFMG (Brésil)
BIOLAB SANUS FARMACÊUTICA LTDA. (Brésil)
UNIÃO QUÍMICA FARMACÊUTICA NACIONAL S. A. (Brésil)
BIOSINTÉTICA FARMACÊUTICA LTDA. (Brésil)
Inventeur(s)
Santos, Robson Augusto Souza Dos
Millán, Rubén Dario Sinisterra
Frezard, Frédéric Jean Georges
Gonçalves, Andrey Christian Da Costa
Silva, Rodrigo Araújo Fraga Da
Abrégé
The present invention relates to the use of Ang-(1-7) and/or Ang-(1-7) receptor agonist and/or Ang (1-7) analogue in treating/restoring erectile dysfunction.
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP (Brésil)
Inventeur(s)
Chudzinski-Tavassi, Ana Marisa
Falci, Marcio
Maria, Durvanei Augusto
Reis, Cleyson Valença
Abrégé
The invention refers to pharmaceutical compositions and cosmetic compositions comprising a prophylactic or therapeutically effective quantity of at least one polypeptide substantially identical to Lopap (a lipocalin-related protein with prothrombin activating protease activity). The invention refers to the use of these compositions as modulators of cell death and anti-aging agents.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C12N 15/12 - Gènes codant pour des protéines animales
51.
ORAL FORMULATIONS COMPRISING ONDANSETRON AND A HIGHLY DOSED SWEETEN
The present invention provides pharmaceutical compositions for oral use, characterized by the fact of containing soluble salts of ondansetron and sweeteners with high sweetening power, in high proportions in relation to the active ingredient.
A61K 31/403 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil condensés avec des carbocycles, p. ex. carbazole
A61K 45/08 - Mélanges d'un ingrédient actif et d'une substance auxiliaire, ni l'un ni l'autre n'étant chimiquement caractérisés, p. ex. antihistaminique et agent tensio-actif
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Produits de parfumerie, cosmétiques, huiles essentielles,
savons, substances pour laver, amidon pour le linge,
matières à détacher, matières à nettoyer et à polir (sauf
pour le cuir). Médicaments, produits chimiques pour la médecine et
l'hygiène, drogues pharmaceutiques, emplâtres, étoffes pour
pansements, produits pour la destruction d'animaux et de
végétaux, désinfectants.
