Provided, in some aspects, is directed to oral drug dosage forms configured to release a drug at a desired location in the colon of an individual. As provided in certain aspects, the oral drug dosage forms comprise a drug component comprising an erodible material admixed with the drug, and a delay component not admixed with the drug, wherein the delay component is configured to prevent release of the drug from the drug component until the oral drug dosage form reaches the colon of the individual following administration. In other aspects, the provided is directed to methods of designing, methods of making, such as using three-dimensional printing, and methods of treatment associated with the oral drug dosage forms described herein.
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
3.
ADDITIVE MANUFACTURING SYSTEM FOR CONTINUOUSLY PRODUCING DRUG PRODUCT AND METHOD
Disclosed are an additive manufacturing system for producing a drug product and a method for operating the system. In some embodiments, the system allows for additive manufacturing for a drug product in a mode of continuous feeding and production, and also ensures precise allocation of the amount of a printed material to guarantee the accuracy, quality, and consistency of the drug product.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
Provided herein are drug dosage forms designed to provide a desired retention in an individual based on geometric differences between a pre-administration and post-administration state of the dosage form. In certain aspects, provided are oral drug dosage forms comprising a swellable and expandable material configured, upon swelling or expanding, to drive expansion of the overall size of the oral drug dosage forms such that the oral drug dosage forms are retained in the stomach for a desired period of time. In certain other aspects, provided is directed to components useful for the oral drug dosage forms taught herein. In certain other aspects, provided is directed to methods of designing, methods of making, such as involving three-dimensional (3D) printing, injection molding, ultrasonic welding, or any combination thereof, commercial batches, and methods of delivering a drug to an individual comprising administering an oral drug dosage form taught herein.
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A method for creating pharmaceutical products by additive manufacturing comprises: receiving a plurality of unit measurements corresponding to a plurality of pharmaceutical dosage units, wherein the plurality of pharmaceutical dosage units are generated using a plurality of nozzles of an additive manufacturing system; determining whether a sum of the plurality of unit measurements differs from a target batch measurement by more than a predefined threshold; in accordance with a determination that the sum differs from the target batch measurement by more than the predefined threshold, adjusting one or more nozzles of the plurality of nozzles based on an average of the plurality of unit measurements; and in accordance with a determination that the sum does not differ from the target batch measurement by more than the predefined threshold, adjusting one or more nozzles of the plurality of nozzles based on a target unit measurement.
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/40 - Structures de support des objets en 3D pendant la fabrication, lesdites structures devant être sacrifiées après réalisation de la fabrication
6.
HIGH-THROUGHPUT AND HIGH-PRECISION PHARMACEUTICAL ADDITIVE MANUFACTURING SYSTEM
The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
Disclosed are a modified-release oral pharmaceutical dosage form and a related preparation method therefor, for example, a three-dimensional printing method is used.
An oral pharmaceutical dosage form, which is intended to provide the desired retention in an individual on the basis of geometric differences between dosage form states before and after administration. The oral pharmaceutical dosage form comprises swellable and expandable material (5). The material (5), upon swelling or expansion, drives the overall size of the oral pharmaceutical dosage form to expand, thereby allowing the oral pharmaceutical dosage form to remain in the stomach for a desired period of time.
The present disclosure, in some aspects, is directed to methods of designing an oral drug dosage form formulated and configured to have a desired pharmacokinetic profile. In other aspects, the present disclosure is directed to oral drug dosage forms having a desired pharmacokinetic profile, and methods of making, such as three-dimensional printing, such oral drug dosage forms.
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
B33Y 80/00 - Produits obtenus par fabrication additive
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
G16H 70/40 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des médicaments, p. ex. leurs effets secondaires ou leur usage prévu
10.
ORAL DRUG DOSAGE FORM FOR TARGETED DRUG DELIVERY BASED ON TRACKING MARKER AND METHODS OF DESIGN AND USE THEREOF
Provided is an oral drug dosage form configured to be used for targeted drug delivery at a desired gastrointestinal location, methods of design and use related to the oral drug dosage form.
Provided is an oral drug dosage form configured to be used for targeted drug delivery at a desired gastrointestinal location, methods of design and use related to the oral drug dosage form.
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
A 3D printing system comprises first and second melt extrusion modules, first and second printing modules, and a platform with a driving mechanism. Each extrusion module is configured to receive a respective first or second initial material and heat and extrude that material, so that material is converted into a respective first or second melt and the respective first or second melt is extruded from the respective first or second melt extrusion module. Each printing module is configured to receive the melt extruded from the respective first or second melt extrusion module and guide the respective melt to be extruded. The platform is configured to receive either or both of the melts extruded through the respective first or second printing module. The platform driving mechanism is configured to drive the platform to move between a position below the first printing module and a position below the second printing module.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
Provided herein are a pharmaceutical dosage form and a method for preparing thereof, such as a pharmaceutical dosage form prepared by a three-dimensional printing method. Pharmaceutical dosage forms loaded with liquid or semi-solid materials, and pharmaceutical dosage forms loaded with solid material are both provided.
A method for 3D printing an oral drug dosage form comprises providing a homogenous melted mixture of an API and a first erodible material, a melted substrate, and a melted second erodible material; extruding the homogenous melted mixture through a printing nozzle; depositing the extruded mixture on a planar surface; separately extruding the melted substrate and the melted second erodible material through the printing nozzle; separately depositing the extruded melted substrate and the extruded melted second erodible material on the planar surface, thereby obtaining the oral dosage form. The dosage form comprises a water insoluble substrate forming a compartment and a drug content contained within the compartment. The drug content comprises the first erodible material admixed with the API. The compartment is sealed by a plug comprising die second erodible material not admixed with the API.
Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt a pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
B29C 64/171 - Procédés de fabrication additive spécialement adaptés à la fabrication d'objets multiples en 3D
Disclosed herein are high throughput, efficient, and simplified unloading and packaging systems and methods for large-scale production of pharmaceutical units using additive manufacturing. The disclosed systems and methods may unload, inspect, package, and trace pharmaceutical units, produced by an additive manufacturing system, that are not damaged or deformed. The unloading and packaging system can include one or more unloading and packaging devices. The unloading and packaging device can include a modular configuration having modules. Individual modules to be arranged in any relative order, at any location, and with any number in the unloading and packaging device. The flexibility of the modular configuration allows one or more modules to be removed or added at any given time due to, e.g., expansion, downsizing, module repair, module upgrades, etc. High throughput can be achieved by operating unloading and packaging devices independently and in parallel.
B29C 64/379 - Manutention des objets en 3D obtenus, p. ex. à l’aide de robots
A61J 3/06 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de pilules, tablettes ou pastilles
B29C 64/386 - Acquisition ou traitement de données pour la fabrication additive
B33Y 40/00 - Opérations ou équipements auxiliaires, p. ex. pour la manipulation de matériau
B33Y 50/00 - Acquisition ou traitement de données pour la fabrication additive
B33Y 80/00 - Produits obtenus par fabrication additive
B65B 11/00 - Emballage par enveloppement, p. ex. en enfermant partiellement ou complètement des objets ou des quantités de matériaux dans des bandelettes, feuilles ou enveloppes en matière flexible
B65B 35/18 - Alimentation en articles séparés, p. ex. transport de ces articles par griffes fonctionnant par succion
B65B 41/02 - Alimentation des feuilles ou flans d'enveloppes
B65B 57/02 - Dispositifs de commande automatique, de vérification, d'alarme ou de sécurité sensibles à l'absence, à la présence, à l'alimentation anormale ou à la mauvaise présentation du matériau d'attache ou d'emballage des réceptacles ou des paquets
B65B 65/00 - Parties constitutives particulières aux machines à emballer non prévues ailleursAménagements de ces parties constitutives
B65C 1/02 - Pose d'étiquettes sur la surface plane d'objets, p. ex. sur des emballages, des bandes plates
Additive manufacturing systems for creating pharmaceutical products and methods for operating these systems are disclosed. In some embodiments, the system allows additive pharmaceutical dosage units to be manufactured in a flexible, extendable, modularized, and reconfigurable manner, while maintaining high throughput over time.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
19.
DOSAGE FORMS OF CONTROLLED RELEASE AT SPECIFIC GASTROINTESTINAL SITES
The present disclosure provides a dosage form of controlled release at specific gastrointestinal sites. The dosage form includes a shell defining a first and a second compartment, a first active pharmaceutical ingredient (API) loaded in the first compartment, and a second API loaded in the second compartment, wherein the first API and the second API can be the same or different. The shell includes a first material soluble in a first gastrointestinal site and a second material soluble in a second gastrointestinal site.
The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
21.
ORAL DRUG DOSAGE FORMS FOR COLON DELIVERY AND METHODS OF USE AND MAKING THEREOF
Provided, in some aspects, is directed to oral drug dosage forms configured to release a drug at a desired location in the colon of an individual. As provided in certain aspects, the oral drug dosage forms comprise a drug component comprising an erodible material admixed with the drug, and a delay component not admixed with the drug, wherein the delay component is configured to prevent release of the drug from the drug component until the oral drug dosage form reaches the colon of the individual following administration. In other aspects, the provided is directed to methods of designing, methods of making, such as using three-dimensional printing, and methods of treatment associated with the oral drug dosage forms described herein.
The present disclosure generally relates to an additive manufacturing system. The system can comprise a material supply module for melting and pressurizing a printing material; a micro-screw printing head comprising: a micro-screw comprising a threaded stem portion and a conical head portion, wherein the threaded stem portion is threaded throughout its length for volume measurement; a sleeve, and a nozzle, wherein a distal end of the nozzle comprises: a conical inner surface, and an outlet port for dispensing the print material, wherein the conical inner surface of the nozzle is configured to be in contact with the conical head portion of the micro-screw to stop dispensing the printing material at the nozzle when the micro-screw printing head is in a closed position; a driving module comprising: a rotation motor for driving a rotating motion of the micro-screw, and an actuator for driving a vertical motion of the micro-screw.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
B29C 64/241 - Moyens d’entraînement pour mouvement rotatif
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
B65D 81/38 - Réceptacles, éléments d'emballage ou paquets pour contenus présentant des problèmes particuliers de stockage ou de transport ou adaptés pour servir à d'autres fins que l'emballage après avoir été vidés de leur contenu avec isolation thermique
05 - Produits pharmaceutiques, vétérinaires et hygièniques
07 - Machines et machines-outils
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Veterinary preparations; dietetic foods adapted for medical
purposes; sugar for medical purposes; dental resin for
temporary bridges, crowns and veneers; pharmaceutical
preparations for the treatment of bone diseases; biological
tissue cultures for medical purposes; fever blister
treatment preparations; dysmenorrhea treatment preparations;
pharmaceutical preparations for the central nervous system;
oral analgesics; anticoagulants; tumor suppressing agents;
drugs for medical purposes; pharmaceutical preparations for
the treatment of musculoskeletal disorders; pharmaceutical
preparations for inducing erections; stimulants for the
central nervous system; pharmaceutical preparations for
treating allergies; anti-diabetic pharmaceuticals; calcium
channel blockers; medicines in the form of tablets;
pharmaceutical preparations for the prevention and treatment
of cancer; niacinamide preparations for the treatment of
acne; pharmaceutical preparations for suppressing tumors;
pharmaceutical preparations for treating hypoglycemia;
antihypertensives; chemotherapeutics; antivirals;
anti-infectives; chemico-pharmaceutical preparations; living
cells for medical purposes; parathyroid hormone
preparations; contraceptive preparations; medicines for the
treatment of cardiovascular and cerebrovascular diseases;
hypnotic sedatives; pharmaceutical preparations for treating
respiratory diseases. Machines for pharmaceutical processing industry; 3D
printers; 3D bioprinters. Scientific research for medical purposes in the field of
cancerous diseases; pharmaceutical research services;
testing of pharmaceuticals; research and development
services relating to medicines; development of
pharmaceutical preparations and medicines; pharmaceutical
research and development; drug development services;
pharmaceutical product evaluation; conducting early
evaluations in the field of new pharmaceuticals; research in
the field of pharmaceuticals; quality testing of
pharmaceutical product; advisory services relating to
material testing.
25.
METHODS OF DESIGNING AN ORAL DRUG DOSAGE FORM BASED ON A TARGET PK PROFILE AND DOSAGE FORMS THEREOF
The present disclosure, in some aspects, is directed to methods of deisgning an oral drug dosage form formulated and configured to provide an efficacy-based target pharmocokinetic (PK) profile by optmizing the drug concentration-permeability interplay at any time and/or location in the gastrointestinal tract. In other aspects, the present disclosure is directed to oral drug dosage forms having the desired PK profile, and methods of making, such as three-dimentional printing, such oral drug dosage forms to release the drug (and any functional excipients) with the right amount, at the right time, and at the right location.
Provided herein are drug dosage forms designed to provide a desired retention in an individual based on geometric differences between a pre-administration and post-administration state of the dosage form. In certain aspects, provided are oral drug dosage forms comprising a swellable and expandable material configured, upon swelling or expanding, to drive expansion of the overall size of the oral drug dosage forms such that the oral drug dosage forms are retained in the stomach for a desired period of time. In certain other aspects, provided is directed to components useful for the oral drug dosage forms taught herein. In certain other aspects, provided is directed to methods of designing, methods of making, such as involving three-dimensional (3D) printing, injection molding, ultrasonic welding, or any combination thereof, commercial batches, and methods of delivering a drug to an individual comprising administering an oral drug dosage form taught herein.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
07 - Machines et machines-outils
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Veterinary anthelmintic preparations; dietetic sugar for medical purposes; crystallized rock sugar for medical purposes; dental resin for temporary bridges, crowns and veneers; pharmaceutical preparations for the treatment of bone diseases; biological tissue cultures for medical purposes; fever blister treatment preparations; dysmenorrhea treatment preparations; pharmaceutical preparations for the treatment of the central nervous system, namely, encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease; oral analgesics; anticoagulants; tumor suppressing agents; antitumor drugs for medical purposes; pharmaceutical preparations for the treatment of musculoskeletal disorders; pharmaceutical preparations for inducing erections; stimulants for the central nervous system; pharmaceutical preparations for treating allergies; anti-diabetic pharmaceuticals; calcium channel blockers; vitamin tablets; pharmaceutical preparations for the prevention and treatment of cancer; niacinamide preparations for the treatment of acne; pharmaceutical preparations for treating hypoglycemia; antihypertensives; chemotherapeutics; antivirals; antibiotics for human use; antivirals for human use; antifungals for human use; antiparasitics for human use; antituberculous preparations for human use; chemico-pharmaceutical preparations for the prevention and treatment of cancer; stem cells for medical purposes; parathyroid hormone preparations; contraceptive preparations; medicines for the treatment of cardiovascular and cerebrovascular diseases; hypnotic sedatives; pharmaceutical preparations for treating respiratory diseases; antibiotics for veterinary use; antivirals for veterinary use; antifungals for veterinary use; antiparasitics for veterinary use; antituberculous preparations for veterinary use; veterinary pharmaceutical preparations for periodontal diseases; veterinary pharmaceutical preparations for the prevention and treatment of iron deficiency and anaemia in animals; veterinary pharmaceutical preparations for the treatment of parasites; veterinary preparations for treatment of intestinal bacteria; pharmaceutical preparations for treating malignant tumors; biological preparations made from human blood cells for the treatment of cancer; biological preparations made from living tissues for the treatment of cancer; pharmaceutical preparations for treating digestive system disorders; pharmaceutical preparations for the treatment of genito-urinary and pelvic diseases, disorders and infections, namely infertility, sexually transmitted diseases, incontinence and sexual dysfunction; preparations for the diagnosis and treatment of disorders relating to sexual reproduction and fertility; pharmaceutical preparations for the treatment of mental health disorders; pharmaceutical preparations for the treatment of diseases, disorders and infections of the endocrine system, namely growth and thyroid disorders, and neuromuscular diseases, namely primary periodic paralysis; pharmaceutical preparations for the treatment of endocrine diseases, namely, glucagonoma; pharmaceutical preparations for the treatment of immunologic diseases and disorders namely, autoimmune diseases and disorders.
(2) Unmanned industrial robots for conveying of medicines; 3D printers for pharmaceutical processing industry; 3D bioprinters for pharmaceutical processing industry; nozzles for filling machine for pharmaceuticals; print heads for industrial printing machines used in drugs preparation; industrial mixer for mixing liquids in the pharmaceutical industry; filling machine for pharmaceuticals; drug grinders being machines; machines for pharmaceutical processing industry, namely, drugs and vaccine packaging machines. (1) Scientific research for medical purposes in the field of cancerous diseases; pharmaceutical research services; testing of pharmaceuticals; research and development of vaccines and medicines; development of pharmaceutical preparations and medicines; pharmaceutical research and development; pharmaceutical drug development services; pharmaceutical product evaluation; conducting early evaluations in the field of new pharmaceuticals; research in the field of pharmaceuticals; advisory services relating to material testing.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
07 - Machines et machines-outils
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Veterinary preparations, namely, veterinary vaccines, greases for veterinary purposes, antibiotics for veterinary purposes, bacterial preparations for veterinary purposes, veterinary diagnostic reagents, antibodies for veterinary purposes, and anti-infective products for veterinary use; dietetic foods adapted for medical purposes; sugar for medical purposes; dental resin for temporary bridges, crowns and veneers; pharmaceutical preparations for the treatment of bone diseases; biological tissue cultures for medical purposes; fever blister treatment preparations; dysmenorrhea treatment preparations; pharmaceutical preparations for the central nervous system; oral analgesics; anticoagulants; tumor suppressing agents; pharmaceutical preparations, namely, a drug delivery system comprising polymer-based oral tablets for the continuous release of a wide variety of therapeutic agents; pharmaceutical preparations for the treatment of musculoskeletal disorders; pharmaceutical preparations for inducing erections; stimulants for the central nervous system; pharmaceutical preparations for treating allergies; anti-diabetic pharmaceuticals; calcium channel blockers; medicinal preparations for the mouth to be applied in the form of tablets; pharmaceutical preparations for the prevention and treatment of cancer; niacinamide preparations for the treatment of acne; pharmaceutical preparations for suppressing tumors; pharmaceutical preparations for treating hypoglycemia; antihypertensives; chemotherapeutics; antivirals; anti-infectives; chemico-pharmaceutical preparations for the treatment of cancer, oncological diseases, cardiovascular and cerebrovascular diseases, respiratory diseases, genitourinary diseases, neurological diseases, immune system related diseases, gastrointestinal diseases, musculoskeletal diseases and endocrine metabolism-related diseases; living cells for medical use; parathyroid hormone preparations; contraceptive preparations; medicines for the treatment of cardiovascular and cerebrovascular diseases; hypnotic sedatives; pharmaceutical products for treating respiratory diseases Machines for the pharmaceutical processing industry, namely, print heads for 3D printers for drugs and vaccine preparations, print heads for pharmaceutical drug and vaccine printing machines, industrial robots for conveying of drugs and vaccine preparations, and packaging machines for drugs and vaccine preparations; machines for the pharmaceutical processing industry, namely, for producing drug and vaccine capsules and tablets and mixing machines for drugs and vaccines; 3D printers * for pharmaceutical processing industry; * 3D bioprinters * for pharmaceutical processing industry * Scientific research for medical purposes in the field of cancerous diseases; pharmaceutical research services; testing of pharmaceuticals; research and development services in the field of medicines; development of pharmaceutical preparations and medicines; pharmaceutical research and development; pharmaceutical drug development services; pharmaceutical product evaluation; conducting early evaluations in the field of new pharmaceuticals; technical research in the field of pharmaceutical studies; quality testing of pharmaceutical product; advisory services relating to material testing
30.
DELAYED SUSTAINED-RELEASE ORAL DRUG DOSAGE FORMS OF A JANUS KINASE (JAK) INHIBITOR AND METHODS OF USE
Provided are delayed sustained-release oral drug dosage forms comprising a Janus kinase (JAK) inhibitor, such as tofacitinib. In other aspects, provided are methods of designing, methods of making, such as using three-dimensional printing, and methods of treatment and/or prevention associated with the oral drug dosage forms described herein.
Provided herein are drug dosage forms having a swellable component, which alone or in conjugation with one or more other components of the drug dosage forms expand the overall size of the drug dosage form in the stomach. The drug dosage forms are configured to be retained in the stomach for an extended period of time based on this increase in size of the drug dosage form in the stomach (e.g., retained in the stomach for a period of at least about 24 hours). The drug dosage forms described herein are formulated to release a drug during at least a portion of the stomach residency period. In other aspects, also provided are methods of designing, methods of making, such as using three-dimensional printing, and methods of delivering a drug to an individual, wherein such methods are associated with the drug dosage forms described herein.
A pharmaceutical dosage form, comprising: a pharmaceutical unit which includes a drug, at least one unfolding member, and a retaining member, wherein the unfolding member is connected to the pharmaceutical unit, and is constructed to have a contracted shape, which makes the unfolding member become closer the pharmaceutical unit, and an unfolding shape, which makes the unfolding member become farther away from the pharmaceutical unit; the retaining member is connected to the at least one unfolding member, and applies a constraint force to the at least one unfolding member, so as to make the unfolding member be in the contracted shape; and the retaining member contains a water-soluble material, and is constructed to remove the constraint force from the unfolding member when the water-soluble material is dissolved, such that the at least one unfolding member can change from the contracted shape to the unfolding shape.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
07 - Machines et machines-outils
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Medicines for human purposes; dietary fiber; medicinal
drinks; chemical preparations for pharmaceutical purposes;
pharmaceutical preparations; drugs for medical purposes;
nutraceutical preparations for therapeutic or medical
purposes; Chinese traditional medicinal herbs; dietetic
substances adapted for medical use; medicines for veterinary
purposes. Mills [machines]; sugar coating machines; tablet presses
[machines]; drug grinders [machines]; pill [pharmaceuticals]
making machines; plate and frame filter presses for
pharmaceutical preparations (excluding general plate and
frame filter presses for chemical industry); centrifuges
[machines] for pharmaceutical preparations (excluding
general centrifuges for chemical industry); machines for
pharmaceutical processing industry; 3D printers. Technological research; scientific research; quality
control; chemical research; biological research;
bacteriological research; electronic data storage; computer
programming; consultancy in the design and development of
computer hardware; software as a service [SaaS]; scientific
research for medical purposes in the field of cancerous
diseases; research and development of medicines;
pharmaceutical testing; development of pharmaceutical
preparations and medicines; conducting early evaluations in
the field of new pharmaceuticals; pharmaceutical research;
pharmaceutical research services; pharmaceutical research
and development services; pharmaceutical drug development
services; pharmaceutical product evaluation; inspection of
pharmaceuticals; advisory services relating to material
testing.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
07 - Machines et machines-outils
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Medicines for human purposes; dietary fiber; medicinal
drinks; chemical preparations for pharmaceutical purposes;
pharmaceutical preparations; drugs for medical purposes;
nutraceutical preparations for therapeutic or medical
purposes; Chinese traditional medicinal herbs; dietetic
substances adapted for medical use; medicines for veterinary
purposes. Disintegrators; mills [machines]; sugar coating machines;
tablet presses [machines]; drug grinders [machines]; pill
[pharmaceuticals] making machines; plate and frame filter
presses for pharmaceutical preparations (excluding general
plate and frame filter presses for chemical industry);
centrifuges [machines] for pharmaceutical preparations
(excluding general centrifuges for chemical industry);
machines for pharmaceutical processing industry; 3D
printers. Quality control; scientific research for medical purposes in
the field of cancerous diseases; research and development of
medicines; pharmaceutical testing; development of
pharmaceutical preparations and medicines; conducting early
evaluations in the field of new pharmaceuticals;
pharmaceutical research; pharmaceutical research services;
pharmaceutical research and development services;
pharmaceutical drug development services; pharmaceutical
product evaluation; inspection of pharmaceuticals; advisory
services relating to material testing.
Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
B29C 64/171 - Procédés de fabrication additive spécialement adaptés à la fabrication d'objets multiples en 3D
A high throughput, efficient, and simplified unloading and packaging systems and methods for large-scale production of pharmaceutical units (104) using additive manufacturing. The systems and methods may unload, inspect, package, and trace pharmaceutical units, produced by an additive manufacturing system (900), that are not damaged or deformed. The unloading and packaging system can include one or more unloading and packaging devices (100). The unloading and packaging device can include a modular configuration having modules. Individual modules to be arranged in any relative order, at any location, and with any number in the unloading and packaging device. The flexibility of the modular configuration allows one or more modules to be removed or added at any given time due to, e.g., expansion, downsizing, module repair, module upgrades, etc. High throughput can be achieved by operating unloading and packaging devices independently.
B65B 35/18 - Alimentation en articles séparés, p. ex. transport de ces articles par griffes fonctionnant par succion
A61J 3/06 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de pilules, tablettes ou pastilles
B29C 64/379 - Manutention des objets en 3D obtenus, p. ex. à l’aide de robots
B29C 64/386 - Acquisition ou traitement de données pour la fabrication additive
B33Y 40/00 - Opérations ou équipements auxiliaires, p. ex. pour la manipulation de matériau
B33Y 50/00 - Acquisition ou traitement de données pour la fabrication additive
B33Y 80/00 - Produits obtenus par fabrication additive
B65B 11/00 - Emballage par enveloppement, p. ex. en enfermant partiellement ou complètement des objets ou des quantités de matériaux dans des bandelettes, feuilles ou enveloppes en matière flexible
B65B 41/02 - Alimentation des feuilles ou flans d'enveloppes
B65B 57/02 - Dispositifs de commande automatique, de vérification, d'alarme ou de sécurité sensibles à l'absence, à la présence, à l'alimentation anormale ou à la mauvaise présentation du matériau d'attache ou d'emballage des réceptacles ou des paquets
B65B 65/00 - Parties constitutives particulières aux machines à emballer non prévues ailleursAménagements de ces parties constitutives
B65C 1/02 - Pose d'étiquettes sur la surface plane d'objets, p. ex. sur des emballages, des bandes plates
The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
A 3D printing device (100), comprising a melt extrusion module (102), a printing module (103), and a platform module (104). The melt extrusion module (102) comprises a processing chamber (121) consisting of a feed inlet (124) and a discharge outlet (125), as well as an extrusion means (122) and a heating means (123) disposed at the processing chamber; the melt extrusion module (102) is configured to receive an initial material from the feed inlet (124) of the processing chamber (121), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet (125) of the processing chamber (121). The printing module (103) is communicated with the discharge outlet (125) of the processing chamber (121) and is provided with a nozzle (131); the printing module (103) is configured to receive the molten body extruded from the discharge outlet (125) of the processing chamber (121) and guide the molten body to be extruded out of the nozzle (131). The platform module (104) is configured to receive the molten body extruded from the nozzle (131).
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.
The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
B33Y 40/00 - Opérations ou équipements auxiliaires, p. ex. pour la manipulation de matériau
Provided are delayed sustained-release oral drug dosage forms comprising a Janus kinase (JAK) inhibitor, such as tofacitinib. In other aspects, provided are methods of designing, methods of making, such as using three-dimensional printing, and methods of treatment and/or prevention associated with the oral drug dosage forms described herein.
A pharmaceutical dosage form, comprising: a pharmaceutical unit which includes a medicament, at least one unfolding member, and a retaining member, wherein the unfolding member is connected to the pharmaceutical unit, and is constructed to have a contracted shape, which makes the unfolding member become closer to the pharmaceutical unit, and an unfolding shape, which makes the unfolding member become farther away from the pharmaceutical unit; the retaining member is connected to the at least one unfolding member, and applies a constraint force to the at least one unfolding member, so as to make the unfolding member be in the contracted shape; and the retaining member contains a water-soluble material, and is constructed to remove the constraint force from the unfolding member when the water-soluble material is dissolved, such that the at least one unfolding member can change from the contracted shape to the unfolding shape.
A61D 7/00 - Dispositifs ou méthodes pour l'introduction de remèdes, solides, liquides ou gazeux ou d'autres produits dans ou sur le corps des animaux
A61J 3/07 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de capsules ou de petits conteneurs similaires à absorber par voie buccale
Provided herein are drug dosage forms having a swellable component, which alone or in conjugation with one or more other components of the drug dosage forms expand the overall size of the drug dosage form in the stomach. The drug dosage forms are configured to be retained in the stomach for an extended period of time based on this increase in size of the drug dosage form in the stomach (e.g., retained in the stomach for a period of at least about 24 hours). The drug dosage forms described herein are formulated to release a drug during at least a portion of the stomach residency period. In other aspects, also provided are methods of designing, methods of making, such as using three-dimensional printing, and methods of delivering a drug to an individual, wherein such methods are associated with the drug dosage forms described herein.
The present disclosure generally relates to an additive manufacturing system. The system can comprise a material supply module for melting and pressurizing a printing material; a micro-screw printing head comprising: a micro-screw comprising a threaded stem portion and a conical head portion, wherein the threaded stem portion is threaded throughout its length for volume measurement; a sleeve, and a nozzle, wherein a distal end of the nozzle comprises: a conical inner surface, and an outlet port for dispensing the print material, wherein the conical inner surface of the nozzle is configured to be in contact with the conical head portion of the micro-screw to stop dispensing the printing material at the nozzle when the micro-screw printing head is in a closed position; a driving module comprising: a rotation motor for driving a rotating motion of the micro-screw, and an actuator for driving a vertical motion of the micro-screw.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
B29C 64/241 - Moyens d’entraînement pour mouvement rotatif
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
B65D 81/38 - Réceptacles, éléments d'emballage ou paquets pour contenus présentant des problèmes particuliers de stockage ou de transport ou adaptés pour servir à d'autres fins que l'emballage après avoir été vidés de leur contenu avec isolation thermique
48.
HIGH-PRECISION ADDITIVE MANUFACTURING DEVICE AND HIGH-THROUGHPUT ADDITIVE MANUFACTURING SYSTEM
The present disclosure generally relates to an additive manufacturing system. The system can comprise a material supply module for melting and pressurizing a printing material; a micro-screw printing head comprising: a micro-screw comprising a threaded stem portion and a conical head portion, wherein the threaded stem portion is threaded throughout its length for volume measurement; a sleeve, and a nozzle, wherein a distal end of the nozzle comprises: a conical inner surface, and an outlet port for dispensing the print material, wherein the conical inner surface of the nozzle is configured to be in contact with the conical head portion of the micro-screw to stop dispensing the printing material at the nozzle when the micro-screw printing head is in a closed position; a driving module comprising: a rotation motor for driving a rotating motion of the micro-screw, and an actuator for driving a vertical motion of the micro-screw.
The present disclosure generally relates to an additive manufacturing system. The system can comprise a material supply module for melting and pressurizing a printing material; a micro-screw printing head comprising: a micro-screw comprising a threaded stem portion and a conical head portion, wherein the threaded stem portion is threaded throughout its length for volume measurement; a sleeve, and a nozzle, wherein a distal end of the nozzle comprises: a conical inner surface, and an outlet port for dispensing the print material, wherein the conical inner surface of the nozzle is configured to be in contact with the conical head portion of the micro-screw to stop dispensing the printing material at the nozzle when the micro-screw printing head is in a closed position; a driving module comprising: a rotation motor for driving a rotating motion of the micro-screw, and an actuator for driving a vertical motion of the micro-screw.
A high throughput, efficient, and simplified unloading and packaging systems and methods for large-scale production of pharmaceutical units (104) using additive manufacturing. The systems and methods may unload, inspect, package, and trace pharmaceutical units, produced by an additive manufacturing system (900), that are not damaged or deformed. The unloading and packaging system can include one or more unloading and packaging devices(100). The unloading and packaging device can include a modular configuration having modules. Individual modules to be arranged in any relative order, at any location, and with any number in the unloading and packaging device. The flexibility of the modular configuration allows one or more modules to be removed or added at any given time due to, e.g., expansion, downsizing, module repair, module upgrades, etc. High throughput can be achieved by operating unloading and packaging devices independently.
The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
52.
ORAL DRUG DOSAGE FORMS HAVING A DESIRED PK PROFILE AND METHODS OF DESIGNING AND PRODUCING THEREOF
The present disclosure, in some aspects, is directed to methods of designing an oral drug dosage form formulated and configured to have a desired pharmacokinetic profile. In other aspects, the present disclosure is directed to oral drug dosage forms having a desired pharmacokinetic profile, and methods of making, such as three-dimensional printing, such oral drug dosage forms.
B33Y 80/00 - Produits obtenus par fabrication additive
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
G16H 70/40 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des médicaments, p. ex. leurs effets secondaires ou leur usage prévu
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
53.
High-throughput and high-precision pharmaceutical additive manufacturing system
The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.
A 3D printing device (100), comprising a melt extrusion module (102), a printing module (103), and a platform module (104). The melt extrusion module (102) comprises a processing chamber (121) consisting of a feed inlet (124) and a discharge outlet (125), as well as an extrusion means (122) and a heating means (123) disposed at the processing chamber; the melt extrusion module (102) is configured to receive an initial material from the feed inlet (124) of the processing chamber (121), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet (125) of the processing chamber (121). The printing module (103) is communicated with the discharge outlet (125) of the processing chamber (121) and is provided with a nozzle (131); the printing module (103) is configured to receive the molten body extruded from the discharge outlet (125) of the processing chamber (121) and guide the molten body to be extruded out of the nozzle (131). The platform module (104) is configured to receive the molten body extruded from the nozzle (131).
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
A dosage form of controlled release at specific gastrointestinal sites is provided. The dosage form includes a shell defining a first and a second compartment, a first active pharmaceutical ingredient (API) loaded in the first compartment, and a second API loaded in the second compartment, wherein the first API and the second API can be the same or different. The shell includes a first material soluble in a first gastrointestinal site and a second material soluble in a second gastrointestinal site.
In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e. g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e. g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e. g., a drug) or areagent, and/or amount of the compound (e. g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61J 3/00 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration
A61J 3/07 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de capsules ou de petits conteneurs similaires à absorber par voie buccale
57.
Oral drug dosage forms compromising a fixed-dose of an ADHD non-stimulant and an ADHD stimulant
The present disclosure provides oral drug dosage forms comprising: (a) an erodible non-stimulant material admixed with an ADHD non-stimulant; and (b) an erodible stimulant material admixed with an ADHD stimulant, wherein the erodible non-stimulant material admixed with the ADHD non-stimulant is embedded in a substrate material, and wherein upon exposure to gastrointestinal fluid the ADHD non-stimulant is released according to a desired non-stimulant release profile and the ADHD stimulant is released according to a desired stimulant release profile. In some embodiment, the ADHD non-stimulant is released according to a sustained release profile. In some embodiments, the ADHD stimulant is released according to an immediate release profile. The oral drug dosage forms of the present disclosure are useful for the treatment of attention deficit hyperactivity disorder (ADHD). Also provided herein are methods of designing and manufacturing the oral drug dosage forms described herein.
Provided herein are methods of designing an oral drug dosage form formulated and configured to have a desired pharmacokinetic profile. In other aspects, its disclosure is directed to oral drug dosage forms having a desired pharmacokinetic profile, and methods of making, such as three-dimensional printing, such oral drug dosage forms.
Provided are pharmaceutical products manufactured using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.
B29C 64/00 - Fabrication additive, c.-à-d. fabrication d’objets en trois dimensions [3D] par dépôt additif, agglomération additive ou stratification additive, p. ex. par impression en 3D, stéréolithographie ou frittage laser sélectif
Provided are pharmaceutical products manufactured using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.
B29C 64/00 - Fabrication additive, c.-à-d. fabrication d’objets en trois dimensions [3D] par dépôt additif, agglomération additive ou stratification additive, p. ex. par impression en 3D, stéréolithographie ou frittage laser sélectif
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(Based on 44(e)) Pharmaceutical preparations for the treatment of autoimmune, cardiovascular, central nervous system, endocrine, gastrointestinal, genetic, immunological, infectious, inflammatory, menopausal, metabolic, musculoskeletal, neurodegenerative, neurological, neuromuscular, ophthalmological, psychiatric, respiratory, urogenital, urological and viral diseases and disorders (Based on Use in Commerce) Pharmaceutical research and development; research and development of technology in the field of pharmaceutical formulation, design, and creation; development of new technology for others in the field of pharmaceuticals; development of pharmaceutical formulations and drug delivery systems
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(Based on 44(e)) Pharmaceutical preparations for the treatment of autoimmune, cardiovascular, central nervous system, endocrine, gastrointestinal, genetic, immunological, infectious, inflammatory, menopausal, metabolic, musculoskeletal, neurodegenerative, neurological, neuromuscular, ophthalmological, psychiatric, respiratory, urogenital, urological and viral diseases and disorders (Based on Use in Commerce) Pharmaceutical research and development; research and development of technology in the field of pharmaceutical formulation, design, and creation; development of new technology for others in the field of pharmaceuticals; development of pharmaceutical formulations and drug delivery systems
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(Based on 44(e)) Pharmaceutical preparations for the treatment of autoimmune, cardiovascular, central nervous system, endocrine, gastrointestinal, genetic, immunological, infectious, inflammatory, menopausal, metabolic, musculoskeletal, neurodegenerative, neurological, neuromuscular, ophthalmological, psychiatric, respiratory, urogenital, urological and viral diseases and disorders (Based on Use in Commerce) Pharmaceutical research and development; research and development of technology in the field of pharmaceutical formulation, design, and creation; development of new technology for others in the field of pharmaceuticals; development of pharmaceutical formulations and drug delivery systems
Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B33Y 80/00 - Produits obtenus par fabrication additive
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Processing and treating of pharmaceutical materials; Providing customized 3D Printing for others Technological research in the field of pharmaceutics; Research and development of new products for others; Development and research services of drugs; Development of pharmaceutical preparations and pharmaceuticals
A 3D printing device (100), comprising a melt extrusion module (102), a printing module (103), and a platform module (104). The melt extrusion module (102) comprises a processing chamber (121) consisting of a feed inlet (124) and a discharge outlet (125), as well as an extrusion means (122) and a heating means (123) disposed at the processing chamber; the melt extrusion module (102) is configured to receive an initial material from the feed inlet (124) of the processing chamber (121), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet (125) of the processing chamber (121). The printing module (103) is communicated with the discharge outlet (125) of the processing chamber (121) and is provided with a nozzle (131); the printing module (103) is configured to receive the molten body extruded from the discharge outlet (125) of the processing chamber (121) and guide the molten body to be extruded out of the nozzle (131). The platform module (104) is configured to receive the molten body extruded from the nozzle (131).
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
B29C 64/20 - Appareil pour la fabrication additiveDétails ou accessoires à cet effet
The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system (102) configured to melt and pressurize a material, a pressure sensor (214) configured to detect the pressure of the material within the device, and a control switch (216) comprising a sealing needle (218) operable in an open position and a closed position. The sealing needle (218) extends through a feed channel (208) containing the material and includes a tapered end (224), wherein the tapered end (224) of the sealing needle (218) engages a tapered inner surface of a nozzle (212) to inhibit flow of the material through the nozzle (212) when the sealing needle (218) is in the closed position.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
The present disclosure provides oral drug dosage forms comprising: (a) an erodible non-stimulant material admixed with an ADHD non-stimulant; and (b) an erodible stimulant material admixed with an ADHD stimulant, wherein the erodible non-stimulant material admixed with the ADHD non-stimulant is embedded in a substrate material, and wherein upon exposure to gastrointestinal fluid the ADHD non-stimulant is released according to a desired non-stimulant release profile and the ADHD stimulant is released according to a desired stimulant release profile. In some embodiment, the ADHD non-stimulant is released according to a sustained release profile. In some embodiments, the ADHD stimulant is released according to an immediate release profile. The oral drug dosage forms of the present disclosure are useful for the treatment of attention deficit hyperactivity disorder (ADHD). Also provided herein are methods of designing and manufacturing the oral drug dosage forms described herein.
In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e. g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e. g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e. g., a drug) or a reagent, and/or amount of the compound (e. g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.
In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e. g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e. g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e. g., a drug) or a reagent, and/or amount of the compound (e. g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.
Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system (102) configured to melt and pressurize a material, a pressure sensor (214) configured to detect the pressure of the material within the device, and a control switch (216) comprising a sealing needle (218) operable in an open position and a closed position. The sealing needle (218) extends through a feed channel (208) containing the material and includes a tapered end (224), wherein the tapered end (224) of the sealing needle (218) engages a tapered inner surface of a nozzle (212) to inhibit flow of the material through the nozzle (212) when the sealing needle (218) is in the closed position.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e.g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e.g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e.g., a drug) or a reagent, and/or amount of the compound (e.g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.
B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
B33Y 80/00 - Produits obtenus par fabrication additive
The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
A 3D printing device (100), comprising a melt extrusion module (102), a printing module (103), and a platform module (104). The melt extrusion module (102) comprises a processing chamber (121) consisting of a feed inlet (124) and a discharge outlet (125), as well as an extrusion means (122) and a heating means (123) disposed at the processing chamber; the melt extrusion module (102) is configured to receive an initial material from the feed inlet (124) of the processing chamber (121), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet (125) of the processing chamber (121). The printing module (103) is communicated with the discharge outlet (125) of the processing chamber (121) and is provided with a nozzle (131); the printing module (103) is configured to receive the molten body extruded from the discharge outlet (125) of the processing chamber (121) and guide the molten body to be extruded out of the nozzle (131). The platform module (104) is configured to receive the molten body extruded from the nozzle (131).
B29C 67/00 - Techniques de façonnage non couvertes par les groupes , ou
B29C 64/00 - Fabrication additive, c.-à-d. fabrication d’objets en trois dimensions [3D] par dépôt additif, agglomération additive ou stratification additive, p. ex. par impression en 3D, stéréolithographie ou frittage laser sélectif
79.
Oral drug dosage forms having desired drug release profiles and uses thereof
The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
80.
DOSAGE FORMS OF CONTROLLED RELEASE AT SPECIFIC GASTROINTESTINAL SITES
A dosage form of controlled release at specific gastrointestinal sites is provided. The dosage form includes a shell defining a first and a second compartment, a first active phamaecutical ingredient (API) loaded in the first compartment, and a second API loaded in the second compartment, wherein the first API and the second API can be the same or different. The shell includes a first material soluble in a first gastrointestinal site and a second material soluble in a second gastrointestinal site.
A dosage form of controlled release at specific gastrointestinal sites is provided. The dosage form includes a shell defining a first and a second compartment, a first active phamaecutical ingredient (API) loaded in the first compartment, and a second API loaded in the second compartment, wherein the first API and the second API can be the same or different. The shell includes a first material soluble in a first gastrointestinal site and a second material soluble in a second gastrointestinal site.
The present invention generally relates to a pharmaceutical dosage form and controlled release of biologically active agents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content.
A61J 3/07 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de capsules ou de petits conteneurs similaires à absorber par voie buccale
A61M 31/00 - Dispositifs pour l'introduction ou la rétention d'agents, p. ex. de remèdes, dans les cavités du corps
The present invention generally relates to a pharmaceutical dosage form and controlled release of biologically active agents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content.
A61J 3/07 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de capsules ou de petits conteneurs similaires à absorber par voie buccale
The present invention generally relates to a pharmaceuticaldosage form and controlled release of biologically activeagents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content.
A method for 3D printing an oral drug dosage form comprises providing a homogenous melted mixture of an API and a first erodible material, a melted substrate, and a melted second erodible material; extruding the homogenous melted mixture through a printing nozzle; depositing the extruded mixture on a planar surface; separately extruding the melted substrate and the melted second erodible material through the printing nozzle; separately depositing the extruded melted substrate and the extruded melted second erodible material on the planar surface, thereby obtaining the oral dosage form. The dosage form comprises a water insoluble substrate fanning a compartment and a drug content contained within the compartment. The drug content comprises the first erodible material admixed with the API. The compartment is sealed by a plug comprising the second erodible material not admixed with the API.
The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
It relates to a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
