CELL-FREE TRNA FRAGMENT-BASED TR-FRET SCREENING AND COMPETITION ASSAY FOR INHIBITORS OF HUMAN TRNA MODIFICATION ENZYMES USEFUL IN THE PREVENTION OR TREATMENT OF TRNA MODIFICATION RELATED CONDITIONS
A Cell-free tRNA fragment-based FRET screening and competition assay for inhibitors of human tRNA modification enzymes useful in the prevention or treatment of tRNA modification-related conditions is provided.
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
G01N 33/542 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p. ex. extinction de fluorescence
2.
CASSETTE CONFIGURED TO CONTAIN A MICROFLUIDIC CHIP
A cassette is configured to contain a microfluidic chip. The cassette includes a base made of rigid material and provided with a first wall. The cassette further includes a cover made of rigid material and provided with a second wall. The cassette has an analysis position and an introduction position. Each of the first wall and the second wall has an optically transparent viewing zone. The cassette further includes a series of connecting orifices, each orifice of the series of connecting orifices being designed to be passed through by a connecting tube allowing the passage of a fluid. The second wall also comprising at least one sample introduction orifice.
An assay using stably transformed human cell lines comprising repetitions of codons sensitive to tRNA modifications upstream of a first luminescence-based reporter gene and repetitions of their synonymous codons upstream of a second luminescence-based reporter gene is helpful in rapidly identifying modulators of tRNA modifying enzymes.
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
4.
ACCESSORY FOR A PLATE OF A MICROFLUIDIC EXPERIMENTATION DEVICE, AND MICROFLUIDIC EXPERIMENTATION DEVICE
Plate accessory for a microfluidic experimentation device comprising a first part and at least a second part, said second part being detachable from said first part, said first part having a plurality of through-holes arranged to allow the fluidic connection tubings to pass through said first part, said second part having: at least one housing for at least one microfluidic chip dug into in the thickness of said second part and which has a hole for the passage of light, a plurality of holes, each hole being arranged to receive a fluid reservoir.
A container system for receiving a liquid sample has a receptacle including a substantially tubular portion for receiving a predetermined volume of the sample. The substantially tubular portion has a first open end and an at least partially openable second end; and a chamber at least partially surrounding the substantially tubular portion. The chamber has an at least partially open upper portion and a closed bottom.
The invention relates to a cassette intended to contain a microfluidic chip formed from a base made of rigid material and provided with a first wall and from a cover made of rigid material and provided with a second wall, said cassette having an analysis position and an introduction position. The first wall and the second wall each comprise an optically transparent viewing zone, said cassette comprising a series of connecting orifices, each orifice of the series of connecting orifices being designed to be passed through by a connecting tube allowing the passage of a fluid, the second wall also comprising at least one sample introduction orifice.
The invention relates to an accessory for a plate of a microfluidic experimentation device, comprising a first part and at least one second part, said second part being detachable from said first part, said first part having a plurality of through-holes arranged to enable fluid connection tubes to pass through said first part, said second part having: - at least one recess for at least one microfluidic chip, said recess being made in the thickness of said second part and having a light-passage hole, - a plurality of holes, each hole being arranged to accommodate a fluid reservoir.
The invention provides a method for synthesizing a compound of formula
4 represents a hydrogen atom or an alkyl, aryl or a heteroaryl group; and n and m each independently represents an integer from 1 to 5; or a pharmaceutically acceptable salt thereof; or a precursor thereof; wherein the method comprises one or more of the following steps: (a) reacting a compound of formula (II)
3, Y, n and m are as defined above in relation to the compound of formula (I) with an oxygenating agent, a first additive and a second additive in a solvent in a fluidic network or in a batch process under thermal and/or photochemical conditions to form a compound of formula (III):
3, Y, n and m are as defined above in relation to the compound of formula (I), (b) reacting a compound of formula (III) with a nitrogen containing nucleophile in the presence of a third additive and/or a solvent in the fluidic network or in a batch process under thermal conditions to form a compound of formula (IV):
(c) reacting a compound of formula (IV) in a fluidic network or in a batch process, optionally in the presence of a fourth additive, under thermal conditions to form a compound of formula (I); wherein one or more of steps (a), (b) and/or (c) is carried out in a fluidic network that comprises micro- and/or meso-channels having an internal dimension of from 100 μm to 2000 μm.
C07C 209/80 - Préparation de composés contenant des groupes amino liés à un squelette carboné par des réactions photochimiquesPréparation de composés contenant des groupes amino liés à un squelette carboné en utilisant des radicaux libres
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Databases; databases (electronic) with assessment tools with
respect to psychology and logopedics; interactive databases;
database management software; software platforms;
interactive database software enabling clinical staff to
obtain information on the psychometric properties of
assessment tools accessible with respect to psychology and
logopedics. Database management services; data processing,
systematization and management; data management services in
the field of health care. Computer platform as a service [PaaS]; software as a service
[SaaS]; hosting of databases; maintenance of database
software; design and development of software for use in the
context of paramedical technology; development services of
computer data banks; online data storage. Paramedical information; information service with respect to
psychology and speech therapy.
UNIVERSITE DE LIEGE, GEMBLOUX AGRO-BIO TECH (Belgique)
Inventeur(s)
Bureau, Fabrice
Bureau, Clement
Gillet, Laurent
Verleyen, Michael
Abrégé
Disclosed is a container system for receiving a liquid sample, the system comprising a receptacle including a substantially tubular portion for receiving a predetermined volume of the sample, the substantially tubular portion having a first open end and an at least partially openable second end; and a chamber at least partially surrounding the substantially tubular portion, the chamber having an at least partially open upper portion and a closed bottom.
Disclosed is a container system for receiving a liquid sample, the system comprising a receptacle including a substantially tubular portion for receiving a predetermined volume of the sample, the substantially tubular portion having a first open end and an at least partially openable second end; and a chamber at least partially surrounding the substantially tubular portion, the chamber having an at least partially open upper portion and a closed bottom.
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
45 - Services juridiques; services de sécurité; services personnels pour individus
Produits et services
Software; Application software; Collaborative software, Relating to corporate control and participatory safety; software for business auditing; Evaluation software, Relating to reliability; Security software; Risk assessment software; Operational risk management software. Business auditing; Risk management consultancy; Risk management consultancy [business]. Hosting services, software as a service, and rental of software; Software as a service [SaaS]; Provision of computer security risk management programs; Quality audits; development of computer software solutions, in relation to the following fields: Health and safety. Security guard services; Safety evaluation services; Health and safety risk assessment services; Health and safety risk management; Consultancy in the field of safety at work.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Reagents for medical use; Clinical diagnostic reagents; Reactants for medical diagnosis; Biological reagents for medical use; Biological reagents for veterinary use; Chemical reagents for medical or veterinary purposes; Medical preparations. Appliances for medical purposes; Diagnostic kits for medical purposes; Medical sample kits. Scientific research and development; Consultancy in the field of scientific research; Information relating to scientific research in the following fields: Biochemistry, Biotechnology, Virology, epidemiology, Immunology; Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Providing scientific research information and results from an online searchable database; Scientific research for medical purposes; Biological, medical, clinical and veterinary research; Medical, veterinary or pharmacological research.
The present application relates to methods for determining the proportion or quantity of DNA contributed by individual animals to a volume of milk collected from a plurality of individual animals, wherein the method employs allele sampling for DNA sequence polymorphisms in DNA extracted from a sample of the volume of milk by shallow whole genome sequencing (SWGS). The present methods are useful for example in detecting mastitis or subclinical mastitis in animals contributing milk to the volume of milk.
C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme
C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
The invention provides a method for synthesizing a compound of formula
4 represents a hydrogen atom or an alkyl, aryl or a heteroaryl group; and n and m each independently represents an integer from 1 to 5; or a pharmaceutically acceptable salt thereof; or a precursor thereof; wherein the method comprises one or more of the following steps: (a) reacting a compound of formula (II)
3, Y, n and m are as defined above in relation to the compound of formula (I) with an oxygenating agent, a first additive and a second additive in a solvent in a fluidic network or in a batch process under thermal and/or photochemical conditions to form a compound of formula (III):
(b) reacting a compound of formula (III) with a nitrogen containing nucleophile in the presence of a third additive and/or a solvent in the fluidic network or in a batch process under thermal conditions to form a compound of formula (IV):
(c) reacting a compound of formula (IV) in a fluidic network or in a batch process, optionally in the presence of a fourth additive, under thermal conditions to form a compound of formula (I); wherein one or more of steps (a), (b) and/or (c) is carried out in a fluidic network that comprises micro- and/or meso-channels having an internal dimension of from 100 μm to 2000 μm.
C07C 209/80 - Préparation de composés contenant des groupes amino liés à un squelette carboné par des réactions photochimiquesPréparation de composés contenant des groupes amino liés à un squelette carboné en utilisant des radicaux libres
A method for treatment of a bacterial infection in a host mammal in need of such treatment or a method of administering to the host mammal an effective amount of a Triazolo(4,5-d)pyrimidine of formula(I):
2 must be substituted by fluorine.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61L 2/16 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques
17.
Nanoreservoir coated medical devices, biomaterials, and bioprosthetics
Disclosed herein are biomaterial implants, medical devices, or bioprostheses wherein a surface or part thereof is coated with a nanoreservoir comprising a hydrophilic polymer or copolymer backbone crosslinked to a second polymer comprising a hydrophilic backbone and one or more reactive moieties, wherein the nanoreservoir further comprises one or more bioactive molecules, therapeutic molecules, or drugs.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 47/58 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. poly[méth]acrylate, polyacrylamide, polystyrène, polyvinylpyrrolidone, alcool polyvinylique ou résine d’acide sulfonique de polystyrène
The present application relates to methods for determining the proportion or quantity of DNA contributed by individual animals to a volume of milk collected from a plurality of individual animals, wherein the method employs allele sampling for DNA sequence polymorphisms in DNA extracted from a sample of the volume of milk by shallow whole genome sequencing (SWGS). The present methods are useful for example in detecting mastitis or subclinical mastitis in animals contributing milk to the volume of milk.
C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
The invention provides a method for synthesizing a compound of formula (I) wherein each R independently represents an optionally substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy, acyl, carboxyl, hydroxyl, halogen, amino, nitro, cyano, sulfo or sulfhydryl group, in ortho, meta or para position to the cycloalkylamine moiety; R1 and R2 each independently represents a hydrogen atom, a lower alkyl group or a cycloalkyl group; R3 represents a hydrogen group, substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy group; Y represents an oxygen atom, a sulfur atom, a NH group, a NR4 group or a CH2 group; R4 represents a hydrogen atom or an alkyl, aryl or a heteroaryl group; and n and m each independently represents an integer from 1 to 5; or a pharmaceutically acceptable salt thereof; or a precursor thereof; wherein the method comprises one or more of the following steps: (a) reacting a compound of formula (II): (II) wherein R, R3, Y, n and m are as defined above in relation to the compound of formula (I) with an oxygenating agent, a first additive and a second additive in a solvent in a fluidic network or in a batch process under thermal and/or photochemical conditions to form a compound of formula (III): (III) wherein R, R3, Y, n and m are as defined above in relation to the compound of formula (I), (b) reacting a compound of formula (III) with a nitrogen containing nucleophile in the presence of a third additive and/or a solvent in the fluidic network or in a batch process under thermal conditions to form a compound of formula (IV): (IV) wherein R, R1, R2, R3, Y, n and m are as defined above in relation to the compound of formula (I); and/or (c) reacting a compound of formula (IV) in a fluidic network or in a batch process, optionally in the presence of a fourth 20 additive, under thermal conditions to form a compound of formula (I); wherein one or more of steps (a), (b) and/or (c) is carried out in a fluidic network that comprises micro- and/or meso-channels having an internal dimension of from 100 µm to 2000 µm.
C07C 49/337 - Composés saturés comportant des groupes cétone liés à des cycles contenant des groupes hydroxyle
C07C 225/20 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones ayant des groupes amino liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons du squelette carboné
C07C 249/02 - Préparation de composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné de composés contenant des groupes imino
C07C 251/16 - Composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné contenant des groupes imino ayant des atomes de carbone de groupes imino liés à des atomes d'hydrogène ou à des atomes de carbone acycliques à des atomes de carbone d'un squelette carboné non saturé contenant des cycles aromatiques à six chaînons
Electric kitchen utensils and containers; Electric kitchen utensils and containers, namely domestic spirulina planters and harvesting systems; Steam generating apparatus; Cooking appliances; Refrigerating apparatus; Apparatus for drying. Algae, unprocessed, for human or animal consumption; Algae, unprocessed, for human or animal consumption; Agricultural and aquacultural crops, horticulture and forestry products.
09 - Appareils et instruments scientifiques et électriques
31 - Produits agricoles; animaux vivants
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer software and applications solely for photobioreactors and apparatus for producing microalgae, spirulina and cyanobacteria; Photobioreactors for the production of microalgae, spirulina and cyanobacteria with light of wavelength greater than 350nm. Algae, unprocessed, for human or animal consumption; Algae, unprocessed, for human or animal consumption; Agricultural and aquacultural crops, horticulture and forestry products. Scientific research and analysis; Scientific research relating to biology; Computer software design; Software development; Research and development for others; Installation of software; Maintenance of software; Updating of computer software; Rental of software; All of the aforesaid computer software solely relating to computer software for photobioreactors and apparatus for producing microalgae, spirulina and cyanobacteria.
22.
A Medical Device Coated with a Nanoreservoir Comprising Nanoparticles of Nanogel with Bioactive Molecules
Triazolo(4,5-d)pyrimidine derivatives for use in treatment or prevention of bacterial infection in a host mammal in need of such treatment or use as inhibitor of biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals for asbestos diagnostics; Diagnostic reagents, other than for medical use for sale in kit form; Testing reagents for industrial use for the detection of asbestos; Biological or biochemical preparations for the detection of asbestos in buildings. Scientific, technological and laboratory services for use in the diagnostics, analysis and treatment of asbestos in buildings.
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific research apparatus and instruments for use in bioengineering as applied to agri-foodstuffs, agriculture, biotechnology and the environment, in particular relating to the processing of agricultural products or crop modelling in relation to ecosystems. Education; Providing of training; Arranging of conferences, all the aforesaid services being for use in the field of bioengineering as applied to agri-foodstuffs, agriculture, biotechnology and the environment, in particular relating to crop protection, agricultural production, multi-level land use systems, future food supply, genetic enhancement of agro-biological resources. Scientific and technological research services, for use in bioengineering as applied to agri-foodstuffs, agriculture, biotechnology and the environment, in particular the researching of innovative methods for crop production, agricultural production, multi-level land use systems, future food supply, genetic enhancement of agro-biological resources.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceuticals; Medical preparations for use in the prevention and/or treatment of inflammatory diseases including arthritis; Diagnostic biomarkers for inflammatory diseases including arthritis; Diagnostic kits for inflammatory diseases. Scientific and technological services for medical and pharmaceutical use; Publication of the results of clinical trials; Scientific research and development for new diagnostic biomarkers or new medicines for use in the prevention and/or treatment of inflammatory diseases including arthritis. Medical services; Medical consultancy and medical analysis for the treatment of individuals, in particular for patients suffering from diseases and, in particular, inflammatory diseases including arthritis.
09 - Appareils et instruments scientifiques et électriques
Produits et services
(1) Logiciels pour le testing, l'évaluation et la simulation dynamique des performances de tous les types de structures de vibration mécaniques et micro-électro-mécaniques, pour le développement et l'amélioration de modèle de ces structures à partir de mesures expérimentales sur structures physiques réelles en présence de non-linéarité et pour l'analyse modale de ces structures, en particulier dans les domaines automobiles, aéronautique, de l'industrie de génie mécanique et des systèmes micro-électro-mécaniques nommément capteurs, émetteurs/récepteurs acoustiques, accéléromètres, gyroscope, airbags, téléviseurs et smart phones.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Preparations for the cryopreservation of cells for medical and medical research purposes, in particular cryopreserving molecules and buffers for medical and medical research purposes. Cell cryopreservation tubes for medical and medical research purposes, and medical cryopreservation kits. Scientific and technological services in the field of cryopreservation, and research and design relating thereto; Medical and veterinary laboratory services, Including services relating to cell cryopreservation for medical, veterinary and medical research purposes, in particular for cell therapy and medically assisted reproduction; Rental of databases relating thereto. Veterinary services, including services relating to cell cryopreservation for veterinary purposes, in particular cell therapy, medically assisted reproduction, cryopreservation of stem cells and germ cells; Medical services, including services relating to cell cryopreservation for medical purposes, in particular cell therapy, medically assisted reproduction, cryopreservation of stem cells and germ cells.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Computer software for testing, evaluation and dynamic simulation of the performance of vibration structures, for the development or improvement of structure models using experimental measurements of real structures in the presence of non-linearity and for the modal analysis of structures, in particular in the automotive and aeronautical sectors and in the mechanical and microelectromechanical systems industries.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Scientific and technological services for medical purposes and in the field of pharmaceuticals; clinical trials; research and development in the medical and pharmaceutical field, including in the field of companion proteomic markers for diagnosis and new drug development in rheumatology, gastroenterology and pneumology; providing information and data relating to medical and pharmaceutical research and development; development of computer software for data management in medical analyses and research relating thereto; installation and maintenance of computer software on data management for medical and pharmaceutical research and development; providing a website featuring information in the field of medical analysis service. Medical services, medical analysis services including medical proteomic analysis services relating to the treatment of persons, medical advice for patient with disabilities particularly in rheumatology, gastroenterology and pneumology.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer interfaces; Magnetic data carriers, recording discs; Compact discs, DVDs and other digital recording media; Electronic publications. Printed matter, Journals, Newspapers, Printed publications, In particular scientific publications. Scientific and technological services and research and design relating to temperature distribution in structures subjected to fire; Mechanical research, technical project studies, assessing and evaluating the fire resistance of materials.
