The present invention relates to vorasidenib solid-state forms, to a pharmaceutical composition comprising them, and to processes for their preparation.
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
The present invention relates to Tapinarof dimethylacetamide solvate and crystalline forms thereof, processes for preparation and pharmaceutical compositions thereof. Furthermore, the invention concerns its use for the preparation of a medicament, preferably for the treatment of skin diseases.
C07C 39/21 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques ne contenant que des cycles aromatiques à six chaînons dans la partie cyclique, avec une insaturation autre que celle des cycles au moins un groupe hydroxyle étant lié à un cycle non condensé
C07C 233/05 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec des atomes de carbone de groupes carboxamide liés à des atomes de carbone d'un squelette carboné saturé acyclique ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
The present invention refers to a process for preparing sucrose octasulfate octakistriethylammonium salt (TASOS) powder, comprising the steps of combining a TASOS solution with a polar organic solvent(s) and triethylamine, thereby obtaining a TASOS solution, the polar organic solvent(s), and triethylamine; concentrating said TASOS solution; combining it with 2-methyltetrahydrofuran and/or tetrahydrofuran and triethylamine, thereby obtaining a mixture; and stirring said mixture until a white TASOS powder is obtained.
The present invention refers to a process for preparing sucrose octasulfate octakistriethylammonium salt (TASOS) powder, comprising the steps of combining a TASOS solution with a polar organic solvent(s) and triethylamine, thereby obtaining a TASOS solution, the polar organic solvent(s), and triethylamine; concentrating said TASOS solution; combining it with 2-methyltetrahydrofuran and/or tetrahydrofuran and triethylamine, thereby obtaining a mixture; and stirring said mixture until a white TASOS powder is obtained.
The present invention also refers to a sucrose octasulfate octakistriethylammonium salt (TASOS) powder having a purity of at least 96%, the use of the sucrose octasulfate octakistriethylammonium salt (TASOS) powder for preparing a pharmaceutical composition, and the use of tetrahydrofuran or 2-methyltetrahydrofuran as antisolvent for the preparation of TASOS powder.
The present invention refers to a process for preparing sucrose octasulfate octakistriethylammonium salt (TASOS) powder, comprising the steps of combining a TASOS solution with a polar organic solvent(s) and triethylamine, thereby obtaining a TASOS solution, the polar organic solvent(s), and triethylamine; concentrating said TASOS solution; combining it with 2-methyltetrahydrofuran and/or tetrahydrofuran and triethylamine, thereby obtaining a mixture; and stirring said mixture until a white TASOS powder is obtained.
The present invention also refers to a sucrose octasulfate octakistriethylammonium salt (TASOS) powder having a purity of at least 96%, the use of the sucrose octasulfate octakistriethylammonium salt (TASOS) powder for preparing a pharmaceutical composition, and the use of tetrahydrofuran or 2-methyltetrahydrofuran as antisolvent for the preparation of TASOS powder.
Finally, the present invention refers to a pharmaceutical composition prepared by using the sucrose octasulfate octakistriethylammonium salt (TASOS) powder of the present invention, and to the pharmaceutical composition for use in treating cancer.
The present invention relates to solid-state forms of 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide methane sulfonic acid (INN: belumosudil mesylate) and processes for their preparation. Furthermore, the invention relates to a pharmaceutical composition comprising a solid-state form of the present invention and at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment and/or prophylaxis of autoimmune diseases such as graft-versus-host disease (GvHD) and systemic sclerosis.
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
40.
MANDELATE FORM OF 1-(4-(((6-AMINO-5-(4-PHENOXYPHENYL)PYRIMIDIN-4-YL)AMINO)METHYL)PIPERIDIN-1-YL)PROP-2-EN-1-ONE
The present invention relates to a mandelate form of 1-(4-(((6-amino-5-(4-phenoxyphenyl) pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one (INN: evobrutinib) and a process of producing the same. Furthermore, the invention relates to a pharmaceutical composition comprising the mandelate form of evobrutinib and at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment and/or prevention of multiple sclerosis.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
The present invention relates to aqueous high protein concentration compositions, particularly pharmaceutical compositions. The pharmaceutical compositions are useful for delivery of high concentration of the protein active ingredient, such as an antibody, to a patient without high levels of protein aggregation, or other destabilizing factors. The compositions of the invention comprise about 100 mg/mL or more of protein.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
The invention relates to a method and device which allows in real-time the determination of concentration, purity and potency of a biological product during purification and/or concentration processes in order to intervene into the process, either for process control or real time release. The properties of the process stream are continuously monitored by at least two online sensors and with the aid of multivariate statistical analysis so that concentration, purity and potency is determined in real time.
G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
The present invention relates to a crystalline form of sotorasib and to a process for its preparation. Furthermore, the invention relates to a pharmaceutical composition comprising the crystalline form of sotorasib of the present invention and at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment of a cancer with a KRAS mutation.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Préparations pharmaceutiques à usage humain pour la prévention et le traitement du système nerveux central, à savoir infections du système nerveux central, maladies cérébrales, troubles du mouvement du système nerveux central, troubles de la motilité oculaire, maladies de la moelle épinière; préparations pharmaceutiques à usage humain pour la prévention et le traitement de maladies immunologiques, à savoir maladies auto-immunes, syndromes d'immunodéficience; préparations pharmaceutiques à usage humain pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques à usage humain pour la prévention et le traitement de diabètes; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles métaboliques, à savoir diabète, obésité, hyperlipidémie, résistance à l'insuline, syndrome métabolique; anti-inflammatoires à usage humain; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles du système respiratoire; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles du système musculo-squelettique, à savoir maladies du tissu conjonctif, maladies osseuses, maladies rachidiennes, douleurs dorsales, fractures, entorses, blessures cartilagineuses; préparations pharmaceutiques à usage humain pour la prévention et le traitement de maladies génito-urinaires, à savoir maladies urologiques, infertilité, maladies sexuellement transmissibles, maladies pelviennes inflammatoires; préparations pharmaceutiques à usage humain à utiliser en dermatologie, à savoir pour les dermatites, les maladies de pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques à usage humain utilisées en oncologie; préparations pharmaceutiques à usage humain à utiliser en hématologie, à savoir pour le traitement de troubles sanguins; préparations pharmaceutiques à usage humain utilisées dans le cadre de la transplantation d'organes et de tissus; préparations pharmaceutiques à usage humain utilisées en ophtalmologie; préparations pharmaceutiques à usage humain utilisées en gastro-entérologie; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles et maladies oculaires; anti-infectieux à usage humain, antibactériens à usage humain, antiviraux à usage humain, antibiotiques à usage humain, antifongiques systémiques et topiques à usage humain.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Anti-infectives for human use; anti-inflammatories for human use; antibacterial pharmaceutical preparations for human use; antibiotics for human use; antifungal preparations for human use; antivirals for human use; cardiovascular pharmaceutical preparations for human use; dermatological pharmaceutical preparations for human use; pharmaceutical preparations for human use for inhaling for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations for human use acting on the central nervous system; pharmaceutical preparations and substances for human use for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for human use for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculoskeletal system and the genitourinary system; pharmaceutical preparations for human use, used in hematology and in tissue and organ transplantation; pharmaceutical preparations for human use for the prevention and treatment of eye diseases; pharmaceutical preparations for human use for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for human use for the prevention and treatment of diseases and disorders related to the immune system; pharmaceutical preparations for human use for the prevention and treatment of kidney diseases; pharmaceutical preparations for human use for the prevention and treatment of diabetes; pharmaceutical preparations for human use for the prevention and treatment of hypertension; pharmaceutical preparations for human use for the prevention and treatment of skin conditions; pharmaceutical preparations for human use, used in dermatology; pharmaceutical preparations for human use, used in urology; pharmaceutical preparations for human use, used in ophthalmology; pharmaceutical preparations for human use for the prevention and treatment of cancer and tumors; pharmaceutical preparations for human use for the prevention and treatment of allergies; pharmaceutical preparations for human use for the prevention and treatment of bone diseases; pharmaceutical preparations for human use for the prevention and treatment of respiratory diseases and asthma
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Préparations pharmaceutiques à usage humain pour la prévention et le traitement du système nerveux central, à savoir infections du système nerveux central, maladies cérébrales, troubles du mouvement du système nerveux central, troubles de la motilité oculaire, maladies de la moelle épinière; préparations pharmaceutiques à usage humain pour la prévention et le traitement de maladies immunologiques, à savoir maladies auto-immunes, syndromes d'immunodéficience; préparations pharmaceutiques à usage humain pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques à usage humain pour la prévention et le traitement de diabètes; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles métaboliques, à savoir diabète, obésité, hyperlipidémie, résistance à l'insuline, syndrome métabolique; anti-inflammatoires à usage humain; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles du système respiratoire; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles du système musculo-squelettique, à savoir maladies du tissu conjonctif, maladies osseuses, maladies rachidiennes, douleurs dorsales, fractures, entorses, blessures cartilagineuses; préparations pharmaceutiques à usage humain pour la prévention et le traitement de maladies génito-urinaires, à savoir maladies urologiques, infertilité, maladies sexuellement transmissibles, maladies pelviennes inflammatoires; préparations pharmaceutiques à usage humain à utiliser en dermatologie, à savoir pour les dermatites, les maladies de pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques à usage humain utilisées en oncologie; préparations pharmaceutiques à usage humain à utiliser en hématologie, à savoir pour le traitement de troubles sanguins; préparations pharmaceutiques à usage humain utilisées dans le cadre de la transplantation d'organes et de tissus; préparations pharmaceutiques à usage humain utilisées en ophtalmologie; préparations pharmaceutiques à usage humain utilisées en gastro-entérologie; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles et maladies oculaires; anti-infectieux à usage humain, antibactériens à usage humain, antiviraux à usage humain, antibiotiques à usage humain, antifongiques systémiques et topiques à usage humain.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Anti-infectives for human use; anti-inflammatories for human use; antibacterial pharmaceutical preparations for human use; antibiotics for human use; antifungal preparations for human use; antivirals for human use; cardiovascular pharmaceutical preparations for human use; dermatological pharmaceutical preparations for human use; pharmaceutical preparations for human use for inhaling for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations for human use acting on the central nervous system; pharmaceutical preparations and substances for human use for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for human use for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculoskeletal system and the genitourinary system; pharmaceutical preparations for human use, used in hematology and in tissue and organ transplantation; pharmaceutical preparations for human use for the prevention and treatment of eye diseases; pharmaceutical preparations for human use for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for human use for the prevention and treatment of diseases and disorders related to the immune system; pharmaceutical preparations for human use for the prevention and treatment of kidney diseases; pharmaceutical preparations for human use for the prevention and treatment of diabetes; pharmaceutical preparations for human use for the prevention and treatment of hypertension; pharmaceutical preparations for human use for the prevention and treatment of skin conditions; pharmaceutical preparations for human use, used in dermatology; pharmaceutical preparations for human use, used in urology; pharmaceutical preparations for human use, used in ophthalmology; pharmaceutical preparations for human use for the prevention and treatment of cancer and tumors; pharmaceutical preparations for human use for the prevention and treatment of allergies; pharmaceutical preparations for human use for the prevention and treatment of bone diseases; pharmaceutical preparations for human use for the prevention and treatment of respiratory diseases and asthma
The present invention relates to a novel crystal of ensifentrine free base and to a process for its preparation. Furthermore, the invention relates to a pharmaceutical composition comprising said ensifentrine free base crystal, at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment and/or prevention of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis and symptoms of a COVID-19 infection.
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Préparations pharmaceutiques pour la prévention et le traitement du système nerveux central, à savoir les infections du système nerveux central, les maladies du cerveau, les troubles du mouvement du système nerveux central, les troubles de la motilité oculaire, les maladies de la moelle épinière; préparations pharmaceutiques pour la prévention et le traitement de maladies immunologiques, à savoir des maladies auto-immunes, des syndromes de déficit immunitaire; préparations pharmaceutiques pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques pour la prévention et le traitement du diabète; préparations pharmaceutiques pour la prévention et le traitement des troubles métaboliques, à savoir le diabète, l'obésité, l'hyperlipidémie, la résistance à l'insuline, le syndrome métabolique; anti-inflammatoires; préparations pharmaceutiques pour la prévention et le traitement des troubles du système respiratoire; préparations pharmaceutiques pour la prévention et le traitement des troubles du système musculo-squelettique, à savoir les maladies du tissu conjonctif, les maladies des os, les maladies de la colonne vertébrale, les maux de dos, les fractures, les entorses, les blessures du cartilage; préparations pharmaceutiques pour la prévention et le traitement des maladies génito-urinaires, à savoir les maladies urologiques, l'infertilité, les maladies sexuellement transmissibles, les inflammations pelviennes; préparations pharmaceutiques utilisées en dermatologie, à savoir la dermatite, les maladies affectant la pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques utilisées en oncologie; préparations pharmaceutiques utilisées en hématologie, à savoir pour le traitement des troubles sanguins; préparations pharmaceutiques utilisées pour la transplantation de tissus et d'organes; préparations pharmaceutiques utilisées en ophtalmologie; préparations pharmaceutiques utilisées en gastroentérologie; préparations pharmaceutiques pour la prévention et le traitement des troubles et des maladies oculaires; anti-infectieux, antibactériens, antiviraux, antibiotiques, antifongiques systémiques et topiques.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Préparations pharmaceutiques pour la prévention et le traitement du système nerveux central, à savoir les infections du système nerveux central, les maladies du cerveau, les troubles du mouvement du système nerveux central, les troubles de la motilité oculaire, les maladies de la moelle épinière; préparations pharmaceutiques pour la prévention et le traitement de maladies immunologiques, à savoir des maladies auto-immunes, des syndromes de déficit immunitaire; préparations pharmaceutiques pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques pour la prévention et le traitement du diabète; préparations pharmaceutiques pour la prévention et le traitement des troubles métaboliques, à savoir le diabète, l'obésité, l'hyperlipidémie, la résistance à l'insuline, le syndrome métabolique; anti-inflammatoires; préparations pharmaceutiques pour la prévention et le traitement des troubles du système respiratoire; préparations pharmaceutiques pour la prévention et le traitement des troubles du système musculo-squelettique, à savoir les maladies du tissu conjonctif, les maladies des os, les maladies de la colonne vertébrale, les maux de dos, les fractures, les entorses, les blessures du cartilage; préparations pharmaceutiques pour la prévention et le traitement des maladies génito-urinaires, à savoir les maladies urologiques, l'infertilité, les maladies sexuellement transmissibles, les inflammations pelviennes; préparations pharmaceutiques utilisées en dermatologie, à savoir la dermatite, les maladies affectant la pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques utilisées en oncologie; préparations pharmaceutiques utilisées en hématologie, à savoir pour le traitement des troubles sanguins; préparations pharmaceutiques utilisées pour la transplantation de tissus et d'organes; préparations pharmaceutiques utilisées en ophtalmologie; préparations pharmaceutiques utilisées en gastroentérologie; préparations pharmaceutiques pour la prévention et le traitement des troubles et des maladies oculaires; anti-infectieux, antibactériens, antiviraux, antibiotiques, antifongiques systémiques et topiques.
79.
Parenteral pharmaceutical composition comprising cyclophosphamide and a mixture of liquids
The present invention is directed to a parenteral pharmaceutical composition comprising cyclophosphamide and a mixture of specific liquids in specific amounts, respectively.
A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The invention relates to particles comprising odevixibat in a non-crystalline form and to a process for the preparation thereof. The invention further relates to a pharmaceutical composition and/or oral dosage form of odevixibat comprising a plurality of said particles. The particles and the pharmaceutical composition can be used as a medicament, e.g. in the treatment of liver diseases. The invention further relates to odevixibat-2-pentanol solvate which is useful for the preparation of particles comprising odevixibat in a non-crystalline form, a process for the preparation thereof, and to the use of odevixibat-2-pentanol solvate for the preparation of particles comprising odevixibat in a non-crystalline form.
A61K 31/554 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. clothiapine, diltiazem
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
pharmaceutical preparations and substances for use in the treatment of hematological, immune, autoimmune, inflammatory and respiratory diseases and disorders; pharmaceutical preparations and substances for the treatment of cancer and cardiovascular diseases and disorders; pharmaceutical preparations and substances used for the treatment of blood cells and blood vessel diseases and disorders; pharmaceutical preparations and substances for the treatment of oncological, and ophthalmic diseases and disorders; pharmaceutical preparations and substances for the treatment of inflammatory disorders of the central nervous system; pharmaceutical preparations and substances used for the treatment of hemolytic anemia, thrombocytopenia and kidney failure
The present invention relates to an inhaler device for use with an elongate strip medicament carrier comprising a base with a plurality of medicament pockets or blisters and a peelable lidding sheet covering the blisters, the inhaler device comprising; an indexer movable in a first direction to advance a blister pocket into an inhalation position; an opening system for peeling the peelable lidding sheet from the base to expose medicament within each medicament pocket; the opening system comprising a peel management component movable in a first direction corresponding to said first direction of the indexer to delay the peeling action when the indexer is advanced, and in a second, opposite, direction to allow the lidding sheet to be peeled from the base; wherein the indexer and peel management component are separately driven in said first direction so that movement of the indexer does not dictate movement of the peel management component.
The present invention refers to a process for preparing sucrose octasulfate octakistriethylammonium salt (TASOS) powder, comprising the steps of combining a TASOS solution with a polar organic solvent(s) and triethylamine, thereby obtaining a TASOS solution, the polar organic solvent(s), and triethylamine; concentrating said TASOS solution; combining it with 2-methyltetrahydrofuran and/or tetrahydrofuran and triethylamine, thereby obtaining a mixture; and stirring said mixture until a white TASOS powder is obtained. The present invention also refers to a sucrose octasulfate octakistriethylammonium salt (TASOS) powder having a purity of at least 96%, the use of the sucrose octasulfate octakistriethylammonium salt (TASOS) powder for preparing a pharmaceutical composition, and the use of tetrahydrofuran or 2-methyltetrahydrofuran as antisolvent for the preparation of TASOS powder. Finally, the present invention refers to a pharmaceutical composition prepared by using the sucrose octasulfate octakistriethylammonium salt (TASOS) powder of the present invention, and to the pharmaceutical composition for use in treating cancer.
C07H 1/00 - Procédés de préparation des dérivés du sucre
C07H 11/00 - Composés contenant des radicaux saccharide estérifiés par des acides inorganiquesLeurs sels métalliques
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
23233 by weight, and wherein the pharmaceutical formulation comprises an oxidation-sensitive compound. The invention also relates to a medical device comprising such glass container as well as to a method of producing such glass container.
09 - Appareils et instruments scientifiques et électriques
38 - Services de télécommunications
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Software in the field of pharmaceutical products related to multiple sclerosis therapy. Telecommunication services; providing access to databases; providing access to electronic communication networks; podcasting; all the before in the field of pharmaceutical products related to multiple sclerosis therapy. Education, training and entertainment services in the field of pharmaceutical products related to multiple sclerosis therapy. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software; all the before in the field of pharmaceutical products related to multiple sclerosis therapy. Medical services in the field of pharmaceutical products related to multiple sclerosis therapy.
Protective capsules for vials for medical use; plastic protection for vials for medical use; vials for medical use; medical and surgical devices, specially adapted for glass vials and containers for medical use.
The present invention relates to a crystalline form of acoramidis hydrochloride and a process for its preparation. Furthermore, the invention relates to a pharmaceutical composition comprising the crystalline form of acoramidis hydrochloride of the present invention and at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment of TTR amyloidosis (ATTR).
C07D 231/12 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
A61P 25/02 - Médicaments pour le traitement des troubles du système nerveux des neuropathies périphériques
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical products for scientific purposes; chemical
substances and raw materials for manufacturing medicines. Pharmaceutical preparations for human use; dietetic food and
substances for medical and human use; food supplements for
humans. Wholesale and retail sale; advertising, marketing and
promotion; company assistance, management and administrative
services; all the aforesaid services in the field of
chemical substances and raw materials for manufacturing
medicines, pharmaceutical preparations for human use,
dietetic food and preparations for medical and human use,
and food supplements for humans. Treating materials, namely, combining chemical substances
and raw materials for manufacturing medicines,
pharmaceutical preparations for human use, dietetic food and
preparations for medical and human use, and food supplements
for humans; rental of equipment for manufacturing and
assembling chemical substances and raw materials for
manufacturing medicines, pharmaceutical preparations for
human use, dietetic food and preparations for medical and
human use, and food supplements for humans. Quality analysis and control in the field of chemical
substances and raw materials for manufacturing medicines,
pharmaceutical preparations for human use, dietetic food and
preparations for medical and human use and food supplements
for humans.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Préparations pharmaceutiques pour la prévention et le traitement du système nerveux central, à savoir les infections du système nerveux central, les maladies du cerveau, les troubles du mouvement du système nerveux central, les troubles de la motilité oculaire, les maladies de la moelle épinière; préparations pharmaceutiques pour la prévention et le traitement de maladies immunologiques, à savoir des maladies auto-immunes, des syndromes de déficit immunitaire; préparations pharmaceutiques pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques pour la prévention et le traitement du diabète; préparations pharmaceutiques pour la prévention et le traitement des troubles métaboliques, à savoir le diabète, l'obésité, l'hyperlipidémie, la résistance à l'insuline, le syndrome métabolique; anti-inflammatoires; préparations pharmaceutiques pour la prévention et le traitement des troubles du système respiratoire; préparations pharmaceutiques pour la prévention et le traitement des troubles du système musculo-squelettique, à savoir les maladies du tissu conjonctif, les maladies des os, les maladies de la colonne vertébrale, les maux de dos, les fractures, les entorses, les blessures du cartilage; préparations pharmaceutiques pour la prévention et le traitement des maladies génito-urinaires, à savoir les maladies urologiques, l'infertilité, les maladies sexuellement transmissibles, les inflammations pelviennes; préparations pharmaceutiques utilisées en dermatologie, à savoir la dermatite, les maladies affectant la pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques utilisées en oncologie; préparations pharmaceutiques utilisées en hématologie, à savoir pour le traitement des troubles sanguins; préparations pharmaceutiques utilisée pour la transplantation de tissus et d'organes; préparations pharmaceutiques utilisées en ophtalmologie; préparations pharmaceutiques utilisées en gastroentérologie; préparations pharmaceutiques pour la prévention et le traitement des troubles et des maladies oculaires; anti-infectieux, antibactériens, antiviraux, antibiotiques, antifongiques systémiques et topiques.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
The present invention relates to a mandelate form of 1-(4-(((6-amino-5-(4- phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one (INN: evobrutinib) and a process of producing the same. Furthermore, the invention relates to a pharmaceutical composition comprising the mandelate form of evobrutinib and at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment and/or prevention of multiple sclerosis.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
