Produits et services

Downloadable software; downloadable software for chemical analysis and visualization; downloadable software for modelling and visualizing atomic and molecular orbitals and molecular structures. Teaching materials, namely, three-dimensional models of atomic and molecular orbitals and molecular structures. Education; computer training services; providing training and courses in the field of chemistry; training in the use of computer software and computer models for chemical calculations and analysis. Scientific and technological services and research in the field of chemistry; chemical research; scientific analysis and modelling of chemical processes; scientific and technological consultancy in the field of chemistry; consultancy relating to the analysis, modelling and optimization of chemical processes; development of scientific methods and computer models in the field of chemistry; development of computer software; Software as a Service [SaaS] featuring software for chemical analysis and visualization.

Abrégé

The present invention relates to a peptide-based compound for complexing and stabilizing a double stranded oligonucleotide, the compound comprising a structure p-x-b-x′-p′; wherein: i. p and p′ each refer to an oligonucleotide-binding motif; ii. x and x′ each refer to an optional linker motif, and iii. b is a linking motif coupling the oligonucleotide-binding motif to form a dimerized form, wherein motif p and p′ each independently represent a peptide chain having the following fragment comprising a contiguous sequence of at least 14 amino acid residues, and having the following general sequence (I), wherein the N-terminal position 1 is located on the left side: wherein “v” represents a variable amino acid residue position, and wherein “+” represents a positively charged amino acid residue.

Classes IPC  ?

• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C07K 19/00 - Peptides hybrides
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

There is provided a gas measurement device comprising: a gas intake module including a gas intake channel for receiving a gas; a gas sensing chamber including at least one gas sensor for sensing a presence, at least one parameter and/or at least one component of the gas, wherein the at least one gas sensor includes a nitrous oxide sensor; a buffer chamber arranged in fluidic communication between the gas intake module and the gas sensing chamber so that, in use, the gas may flow from the gas intake module to the buffer chamber and from the buffer chamber to the gas sensing chamber.

Classes IPC  ?

• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
• G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
• G01N 33/497 - Analyse physique de matériau biologique de matériau biologique gazeux, p. ex. de l'haleine

Abrégé

A method of determining a parameter of interest of a semiconductor manufacturing process comprising obtaining at least a first value and at least a second value of radiation as detected by a detector configured to detect radiation scattered by a metrology target, determining at least an intermediate first value from a relation between the first value and the second values of radiation 5 obtaining at least a third value and at least a fourth value of radiation as detected by a detector configured to detect radiation scattered by the metrology target, determining at least an intermediate second value from a relation between the third value and the fourth value of radiation determining a parameter of interest of a semiconductor manufacturing process from relation between the at least first intermediate value of radiation and the second intermediate value of radiation.

Classes IPC  ?

• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
• G03H 1/08 - Procédés ou appareils pour produire des hologrammes pour faire des hologrammes synthétiques
• G03H 1/04 - Procédés ou appareils pour produire des hologrammes

Abrégé

144.

Classes IPC  ?

• C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 409/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
• C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 491/048 - Systèmes condensés en ortho avec un seul atome d'oxygène comme hétéro-atome du cycle contenant de l'oxygène le cycle contenant de l'oxygène étant à cinq chaînons
• C07D 495/04 - Systèmes condensés en ortho
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 35/00 - Agents anticancéreux
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
• A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine

Abrégé

The present invention relates to a method for providing a food composition, wherein the method comprises the step of fermenting a fermentable food substrate using a bacterium capable of producing providing a fatty acid amide (FAA) to obtain a fermented food substrate. Preferably, the bacterium capable of producing a fatty acid amide (FAA) is Coprococcus eutactus, or Coprococcus aceti.

Classes IPC  ?

• A23L 33/115 - Acides gras ou leurs dérivésGraisses ou huiles
• A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
• A61K 35/742 - Bactéries sporulées, p. ex. Bacillus coagulans, Bacillus subtilis, clostridium ou Lactobacillus sporogenes
• C12N 1/20 - BactériesLeurs milieux de culture
• C12P 13/02 - Amides, p. ex. chloramphénicol

Abrégé

The invention relates to β-catenin-binding peptides and peptidomimetics comprising an amino acid sequence ESILDEHXQRVW or EYPESILDEHXQRVWR, wherein X is L, M, I, F, Y, W or C, or a variant of said amino acid sequences, and to uses thereof.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• A61K 38/00 - Préparations médicinales contenant des peptides

Abrégé

A method comprising obtaining at least two signals based on scattered radiation from a metrology target and detected by a radiation sensor of a metrology system obtaining a first data set comprising the phases of the at least two signals calculating from the first data set a correction of an intensity value of a signal as detected by a radiation sensor.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• G03H 1/04 - Procédés ou appareils pour produire des hologrammes

Abrégé

The invention relates to methods for tumor marker analysis comprising providing a genomic DNA sample from tumor cells of a patient, preselecting a chromosomal region on the genomic DNA comprising at least part of a potential structural variant (SV); and sequencing the genomic region to characterize the potential SV. The invention further relates to methods for detecting minimal residual disease, monitoring treatment response and tumor progression in a patient by employing the SV, and to personalized therapy based on the identity of the SV.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur

Abrégé

A method of adjusting an amount of extreme ultraviolet (EUV) radiation generated by directing laser pulses onto liquid fuel targets to generate EUV emitting plasma, the laser pulses having a wavelength between 1.6 microns and 2.5 microns, wherein the method comprises adjusting an intensity of the laser pulses, wherein the laser pulses burn fully through the liquid fuel targets before the intensity of the laser pulses is adjusted, and wherein the laser pulses burn fully through the liquid fuel targets after the intensity of the laser pulses is adjusted.

Classes IPC  ?

• H05G 2/00 - Appareils ou procédés spécialement adaptés à la production de rayons X, n'utilisant pas de tubes à rayons X, p. ex. utilisant la génération d'un plasma

Abrégé

A method of correcting an image of a metrology target obtained when the metrology target is illuminated with radiation comprising obtaining a representation image of a metrology target from the image, determining a model of a contribution to the image, contribution which is adversely affecting the quality of the image wherein the model is determined using at least a portion of the representation image of the metrology target and obtaining a correction of the image based on the determined model of the contribution to the image adversely affecting the quality of the image.

Classes IPC  ?

• G03H 1/04 - Procédés ou appareils pour produire des hologrammes
• G03H 1/08 - Procédés ou appareils pour produire des hologrammes pour faire des hologrammes synthétiques
• G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques
• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
• G06T 5/10 - Amélioration ou restauration d'image utilisant le filtrage dans le domaine non spatial

Abrégé

There is provided a Raman spectroscopy apparatus (20) comprising: a deep ultra-violet electromagnetic radiation source (30) for generating a deep ultra-violet electromagnetic radiation beam; an optical arrangement configured to, in use, guide the deep ultra-violet electromagnetic radiation beam from the deep ultra-violet electromagnetic radiation source (30) along an irradiation path towards an object (32), the optical arrangement comprising at least one parabolic optical element (22a, 22b); and an optical detection device (34, 36) configured to, in use, detect at least one optical signal resulting from the irradiation of the object (32).

Classes IPC  ?

• G01J 3/02 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur Parties constitutives
• G01J 3/44 - Spectrométrie RamanSpectrométrie par diffusion

Abrégé

Lactobacillus crispatusLactobacillus crispatusLactobacillus crispatusLactobacillus crispatus having a different expression of GT1, GT2, and GT3 as compared to the first strain. The isolated mixture can be used in the treatment or prevention of bacterial vaginosis, preferably after treatment with antibiotic.

Classes IPC  ?

• A61K 35/747 - Lactobacilles, p. ex. L. acidophilus ou L. brevis
• A61P 15/02 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les pathologies du vagin

Abrégé

The invention provides methods and products for use in treating hyposalivation and/or xerostomia in an individual. The invention further provides methods for increasing salivation in an individual. The methods comprise administering a therapeutic selected from alpha-pinene and/or mastic resin. The invention further provides oral adhering troches comprising said therapeutic.

Classes IPC  ?

• A61K 31/015 - Hydrocarbures carbocycliques
• A61K 31/19 - Acides carboxyliques, p. ex. acide valproïque
• A61K 36/22 - Anacardiaceae (famille du sumac), p. ex. cotinus, sumac ou sumac vénéneux
• A61P 1/02 - Préparations stomatologiques, p. ex. médicaments pour le traitement des caries, des aphtes, des périodontites

Abrégé

A method of generating extreme ultraviolet (EUV) radiation comprising directing laser pulses of a laser beam onto tin targets to generate EUV emitting plasma, wherein the laser pulses have a duration of at least 150 ns and have a wavelength between 1.6 microns and 2.5 microns.

Classes IPC  ?

• H05G 2/00 - Appareils ou procédés spécialement adaptés à la production de rayons X, n'utilisant pas de tubes à rayons X, p. ex. utilisant la génération d'un plasma

Abrégé

A laser system arranged to irradiate a fuel target at a target destination with a laser pulse. The laser system is arranged to produce a plurality of sub-pulses of predetermined pulse length that are temporally combined to form the laser pulse having a specific duration. The laser system further comprises at least one optical element arranged to spatially separate each of the sub-pulses to be incident on the fuel target at corresponding target destinations.

Classes IPC  ?

• H05G 2/00 - Appareils ou procédés spécialement adaptés à la production de rayons X, n'utilisant pas de tubes à rayons X, p. ex. utilisant la génération d'un plasma

Abrégé

The invention relates to a cyclic peptide comprising the amino acid sequence N-terminal-X4X3X2X1-a-Y1Y2Y3Y4-C-terminal, wherein -a- represents a linker, and wherein the peptide comprises a linker -c- between the N-terminal amino acid and C-terminal amino acid, and/or wherein the two amino acids of one or two of the following amino acid pairs form a side chain-to-side chain bridged di-amino acid forming a bridge -b-: X1 and X1; X2 and Y2; X3 and Y3; and X4 and Y4. The invention further relates to the use of said cyclic peptide as a medicament, especially for inhibiting or preventing a Wingless/integrase-1 (Wnt)-dependent disease in an individual in need thereof.

Classes IPC  ?

• C07K 7/54 - Peptides cycliques contenant au moins une liaison peptidique anormale comportant au moins une liaison peptidique anormale dans le cycle
• A61K 38/12 - Peptides cycliques
• A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie

Abrégé

The invention relates to methods of treating a tumor comprising CXCR4 clusters in a subject, comprising simultaneous or sequential administering a CXCR4 cluster inhibitor and a cell death-inducing compound to the subject. The invention further relates to a composition and to a kit of parts, comprising a CXCR4 cluster inhibitor and a cell death-inducing compound.

Classes IPC  ?

• A61K 31/429 - Thiazoles condensés avec des systèmes hétérocycliques
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/635 - Composés contenant des groupes para-N-benzènesulfonyl-N-, p. ex. sulfanilamide, p-nitrobenzènesulfonohydrazide contenant un hétérocycle, p. ex. sulfadiazine
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 35/00 - Agents anticancéreux

Abrégé

A computer-implemented method and system for processing image data in optical coherence tomography. An initial image data captured by employing an optical coherence tomography based imaging technique is received. The image data is modified using a modification function that is configured to change magnitude while maintaining phase of the image data, in order to obtain a modified image data, wherein the modification function is selected based on one or more image quality metrics; applying a filtering process to the modified image data using a filter so as to obtain a filtered image data. A compensation is performed on the filtered image data in order to compensate for alterations resulting from the initial modification of the image data prior to filtering, wherein the compensation is performed based on the modification function and the filter.

Classes IPC  ?

• G06F 18/2131 - Extraction de caractéristiques, p. ex. en transformant l'espace des caractéristiquesSynthétisationsMappages, p. ex. procédés de sous-espace basée sur un traitement dans le domaine de transformation, p. ex. transformée en ondelettes
• G06T 5/70 - DébruitageLissage
• A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
• G01B 9/02091 - Interféromètres tomographiques, p. ex. à cohérence optique
• G06F 18/2134 - Extraction de caractéristiques, p. ex. en transformant l'espace des caractéristiquesSynthétisationsMappages, p. ex. procédés de sous-espace basée sur des critères de séparation, p. ex. analyse en composantes indépendantes

Abrégé

A method of determining optical property of a structure, comprising: obtaining first scattering data, the first scattering data relating to an illumination of the multi-layer structure with illumination radiation in a first polarization state and subsequently capturing radiation scattered from the multi-layer structure; reconstructing one or more first synthetic images of the multi-layer structure using the first scattering data, each of the one or more first synthetic images comprising amplitude and phase information of the radiation scattered from the multi-layer structure; and determining the optical property of the multi-layer structure using the one or more first synthetic images, wherein the optical property comprise complex refractive indices of one or more of the at least two layers of the multi-layer structure, and/or relative heights formed between the at least two layers of the multi-layer structure.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• G01N 23/00 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
• G01N 21/956 - Inspection de motifs sur la surface d'objets
• G01N 21/47 - Dispersion, c.-à-d. réflexion diffuse

Abrégé

The present disclosure relates to compounds of formula (I) comprising a (4-piperidinylmethyl) carboxamide moiety, which can act as modulators of ACKR3. The present disclosure also relates to the use of these compounds as a drug.

Classes IPC  ?

• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons

Abrégé

The invention relates to a system for culturing organisms or cells, a sterile culturing device for use in a system according to the invention, and to a method of culturing organisms and/or cells employing a system according to the invention.

Classes IPC  ?

• C12M 1/26 - Inoculateur ou échantillonneur
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

Abrégé

Multi core waveguides such as fibers for semiconductor metrology systems and methods are described. The multi core waveguides are configured to conduct the radiation from a radiation source to a structure such as a metrology target in one or more layers of a patterned substrate, and the diffracted and/or reflected radiation from the metrology target to a radiation sensor. The multi core waveguides have a length configured to facilitate placement of the radiation source and/or the radiation sensor in a spaced location relative to the patterned substrate. The length of the multi core waveguides is configured to provide increased functional space for other components of a metrology system located proximate to the patterned substrate (e.g., various lenses and/or other optical components).

Classes IPC  ?

• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
• G01N 21/956 - Inspection de motifs sur la surface d'objets

Abrégé

A system (100) for interrogating a photonic circuit (10). A sample light source (30s) is configured to generate sample input light (Li) at a sample frequency (νs). An input coupler (21) is configured to send the sample input light (Li) from the sample light source (30s) into the photonic circuit (10). An output coupler (22) is configured to receive sample output light (Lo) from the photonic circuit (10). A reference light source (30r) is configured to generate reference light (Lr) at a reference frequency (νr). An optical heterodyne detector (40) is configured to combine the sample output light (Lo) with the reference light (Lr); measure the combined light (Lc); and determine a magnitude (P) of an oscillating intensity component (I) in the combined light (Lc) as function of a beating frequency (f) between the sample frequency (νs) and the reference frequency (νr).

Classes IPC  ?

• G01D 5/26 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens optiques, c.-à-d. utilisant de la lumière infrarouge, visible ou ultraviolette
• G01J 1/00 - Photométrie, p. ex. posemètres photographiques
• G01M 11/00 - Test des appareils optiquesTest des structures ou des ouvrages par des méthodes optiques, non prévu ailleurs

Abrégé

in vivoin vivo monitoring of an early stage of diseases, preferably Parkinson's disease, Multiple System Atrophy, Dementia with Lewy Bodies.

Classes IPC  ?

• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
• C07D 261/06 - Composés hétérocycliques contenant des cycles oxazole-1, 2 ou oxazole-1, 2 hydrogéné non condensés avec d'autres cycles comportant plusieurs liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
• C07D 261/14 - Atomes d'azote
• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
• A61K 51/04 - Composés organiques
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present invention relates to a pyrazolidine-3,5-dione compound represented by Formula (I) or pharmaceutically acceptable salt thereof, for use as radioactive tracer compounds in monitoring a disease therapy in an individual by imaging the neuroprotective state of microglia during or prior to its inflammatory state for monitoring the neurodegenerative and neurological diseases.

Classes IPC  ?

• C07D 401/06 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
• A61K 31/4152 - 1,2-Diazoles ayant des groupes oxo liés directement à l'hétérocycle, p. ex. antipyrine, phénylbutazone, sulfinpyrazone
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• C07D 231/32 - Atomes d'oxygène

Produits et services

Scientific research and laboratory apparatus, educational apparatus and simulators.

Abrégé

The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.

Classes IPC  ?

• C07K 16/08 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus
• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

The present invention refers to a stabilized protein complex comprising at least two monomers. The native tertiary and/or quaternary structure of the protein complex is stabilized via crosslinkers having moieties B forming covalent linkages with reactive groups A of the monomer. The invention further relates to a method for producing the stabilized protein complex and monomer, respectively, and to crosslinkers used in this method.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 9/96 - Stabilisation d'une enzyme par formation d'un adduct ou d'une compositionFormation de conjugaisons d'enzymes
• C07K 1/107 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs

Abrégé

A method for measuring a parameter of a substrate, comprises receiving pump radiation. A metrology target on the substrate is irradiated with the received radiation, thereby generating, through resonances, harmonic generated radiation. Using a metrology sensor, intensities are detected of at least two opposite radiation orders of the harmonic generated radiation diffracted by the metrology target. The parameter of the substrate is determined based on the intensities of the at least two opposite radiation orders and a peak wavelength of the harmonic generated radiation.

Classes IPC  ?

• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
• G01B 11/02 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur

Abrégé

The present invention relates to a peptide-based compound for complexing and stabilizing a double stranded oligonucleotide, the compound comprising a structure p-x-b-x'-p'; wherein: i. p and p' each refer to an oligonucleotide-binding motif; ii. x and x' each refer to an optional linker motif, and iii. b is a linking motif coupling the oligonucleotide-binding motif to form a dimerized form, wherein motif p and p' each independently represent a peptide chain having the following fragment comprising a contiguous sequence of at least 14 amino acid residues, and having the following general sequence (I), wherein the N-terminal position 1 is located on the left side: wherein "v" represents a variable amino acid residue position, and wherein "+" represents a positively charged amino acid residue.

Classes IPC  ?

• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
• C07K 19/00 - Peptides hybrides
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C40B 50/04 - Procédés de création de bibliothèques, p. ex. synthèse combinatoire utilisant des techniques de chimie combinatoire dynamique

Abrégé

There is provided an imaging setup comprising an excitation source (203), an optical imaging arrangement (205), a streak camera and a controller, the streak camera including a photocathode (206), a sweep electrode arrangement (211) and an electron detection device (213), wherein: the excitation source (203) is configured to, in use, generate electromagnetic radiation to excite a sample (201) to emit photons; the optical imaging arrangement (205) is configured to, in use, direct the photons from the sample (201) to the photocathode (206) to generate, based on a magnification factor of the optical imaging arrangement (205), an image of the sample (201) on the photocathode (206); the photocathode (206) is configured to, in use, generate electrons on arrival of the photons from the sample (201) at the photocathode (206), wherein the excitation source (203) is configured to, in use, excite different positions of the sample (201) along a selected direction across the sample (201) at respective different excitation times to create a time-shift between the respective generated photons so that the time-shifted photons arrive at different positions of the photocathode (206) along a direction parallel to the selected direction at respective different arrival times; the sweep electrode arrangement (211) is configured to, in use, apply a time¬ varying sweep voltage, at a sweep voltage speed, to selectively deflect the time-shifted electrons generated by the photocathode (206) along a direction parallel to the selected direction; the electron detection device (212,213) is configured to, in use, receive the time-shifted electrons selectively deflected by the sweep electrode arrangement (211); and the controller is configured to, in use, control the optical imaging arrangement (205) to adjust the magnification factor and/or control the sweep electrode arrangement (211) to adjust the sweep voltage speed in order to compensate for the time-shift to reduce or eliminate a distance between the time-shifted electrons in a direction parallel to the selected direction prior to the time-shifted electrons arriving at the screen (212,213).

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/51 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide à l'intérieur d'un récipient, p. ex. dans une ampoule

Abrégé

Disclosed is a Fourier-transform spectrometer comprising a beamsplitting arrangement operable to define a first radiation source and a second radiation source from a common radiation source, and at least one detector operable to detect interferogram data as a function of detection position in at least a first detection plane direction of a detection plane, the interferogram data resulting from interference of a first diverging beam emitted from said first radiation source and a second diverging beam emitted from said second radiation source. A processor is operable to: perform a linearization correction to said interferogram data to obtain linearized interferogram data; and Fourier transform the linearized interferogram data to obtain spectral characteristic data relating to the common radiation source.

Classes IPC  ?

• G01J 3/02 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur Parties constitutives
• G01J 3/453 - Spectrométrie par interférence par corrélation des amplitudes
• G01J 3/36 - Étude de plusieurs bandes d’un spectre à l’aide de détecteurs distincts

Abrégé

A metrology system (100, 300, 400) for analyzing fuel at a target location in an EUV radiation source is disclosed. The metrology system comprises at least one radiation-emitting device (105, 110, 115, 305, 310, 315, 405, 410, 415) configured to emit radiation that is directed towards the target location (120, 320, 420). The metrology system also comprises at least one radiation-sensitive device (150, 350, 450) configured to sense radiation from the at least one radiation-emitting device that has passed through fuel at the target location. The at least one radiation-emitting device is configured to emit radiation of at least two different wavelengths. A radiation source (SO) for an EUV lithography apparatus, and a method of analyzing a fuel at a target location in such an EUV radiation source are also disclosed.

Classes IPC  ?

• H05G 2/00 - Appareils ou procédés spécialement adaptés à la production de rayons X, n'utilisant pas de tubes à rayons X, p. ex. utilisant la génération d'un plasma

Abrégé

A method comprises receiving images representing manipulating cellular bodies that includes exerting force pulses to the bodies on a wall surface; analyzing the images to determine the size of the bodies and tracking locations during and after each of force pulses, the tracking locations defining first trajectories of the bodies moving away from the wall surface and trajectories of the bodies moving towards the wall surface; determining densities of the bodies using the second trajectories and a sedimentation model of the bodies moving towards the wall surface and determining body velocities based on the first trajectories and a velocity model of the bodies moving away from the wall surface; and, determining a contrast factor for each body based on the sizes and the densities, the force applied to the bodies and the body velocities and determining a compressibility for each of the bodies based on the determined contrast factors.

Classes IPC  ?

• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
• G06T 7/60 - Analyse des attributs géométriques
• G06T 7/20 - Analyse du mouvement
• G06T 7/70 - Détermination de la position ou de l'orientation des objets ou des caméras
• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires

Abrégé

There is provided a spectroscopy apparatus for measuring fluorescence signals from a photosynthetic object. The spectroscopy apparatus comprises: one or more light excitation sources (26,28) operable to carry out time-varying excitation of the fluorescence from the photosynthetic object; and one or more fluorescence-sensitive detection channels (36,38,44,46) configured to simultaneously record the fluorescence as a function of time with a microsecond to millisecond time resolution and as a function of wavelength with a wavelength resolution of 10 nm or better, responsive to the excitation of the fluorescence from the photosynthetic object by the or each light excitation source (26,28).

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence

Abrégé

A method for determining a vertical position of a structure on a substrate with respect to a nominal vertical position is disclosed. The method comprises obtaining complex field data relating to scattered radiation from said structure, for a plurality of different wavelengths, determining variation in a phase parameter with wavelength from said complex field data; and determining said vertical position with respect to a nominal vertical position from the determined variation in phase with wavelength.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• G01N 21/21 - Propriétés affectant la polarisation
• G03H 1/04 - Procédés ou appareils pour produire des hologrammes

Abrégé

Disclosed is an illumination arrangement for providing at least one radiation beam for use as an illumination beam and/or reference beam in a metrology device. The illumination arrangement comprises at least one radiation beam modifier module operable to receive source illumination and output a modified radiation beam comprising a first beam component and a second beam component. Each radiation beam modifier module comprises at least one path length varying arrangement for controllably varying the optical path length of at least one of said first beam component and said second beam component, such that said first beam component and second beam component of said modified radiation beam comprise a respective different optical path length.

Classes IPC  ?

• G03F 9/00 - Mise en registre ou positionnement d'originaux, de masques, de trames, de feuilles photographiques, de surfaces texturées, p. ex. automatique
• G02B 5/18 - Grilles de diffraction
• G02B 27/00 - Systèmes ou appareils optiques non prévus dans aucun des groupes ,
• G03H 1/04 - Procédés ou appareils pour produire des hologrammes
• G03F 7/20 - ExpositionAppareillages à cet effet
• G01J 9/00 - Mesure du déphasage des rayons lumineuxRecherche du degré de cohérenceMesure de la longueur d'onde des rayons lumineux
• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
• G02B 21/10 - Condensateurs donnant un éclairage sur fond noir
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 26/06 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la phase de la lumière
• G02B 27/42 - Optique de diffraction

Abrégé

The present disclosure relates to compounds of formula (I) comprising a (4-piperidinylmethyl) carboxamide moiety, which can act as modulators of ACKR3. The present disclosure also relates to the use of these compounds as a drug.

Classes IPC  ?

• C07D 413/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
• A61P 35/00 - Agents anticancéreux

Abrégé

There is provided an optical sensor for sensing a chemical, the optical sensor comprising a periodic arrangement of nanostructures configured to support a surface lattice resonance, wherein the optical sensor is configured to sense the chemical via a modification of an optical property of the nanostructures resulting from absorption of the chemical into the nanostructures or from adsorption of the chemical onto surfaces of the nanostructures, wherein a geometry of the nanostructures is configured to balance a spectral linewidth of the surface lattice resonance and field enhancement within the nanostructures so as to configure a limit of detection of the optical sensor with respect to the sensed chemical.

Classes IPC  ?

• G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique
• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur

Abrégé

The disclosure herein are materials and methods for the treatment of snake bite. Aspects of the disclosure includes pharmaceutical compositions, and kits, both of which may be of use in the treatment of snake bite.

Classes IPC  ?

• A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
• A61K 31/10 - SulfuresSulfoxydesSulfones
• A61K 31/16 - Amides, p. ex. acides hydroxamiques
• A61P 39/02 - Antidotes

Abrégé

Disclosed is a method for measuring a target located on a substrate beneath at least one layer. The method comprises exciting said at least one layer with pump radiation comprising at least one pump wavelength, so as to generate an acoustic wave within said at least one layer which reflects of said target thereby generating an acoustic replica of said target at a surface of said substrate and illuminating said acoustic replica with probe radiation comprising at least one probe wavelength and capturing the resultant scattered probe radiation, scattered from the acoustic replica. One or both of said exciting step and said illuminating step comprises generating Surface Plasmon Polaritons (SPPs) on residual topography of said at least one layer resultant from said target.

Classes IPC  ?

• G03F 9/00 - Mise en registre ou positionnement d'originaux, de masques, de trames, de feuilles photographiques, de surfaces texturées, p. ex. automatique

Abrégé

A strip-loaded optical waveguide (30) comprises a slab portion (32) and a strip portion (34). The strip portion (34) is disposed over or on the slab portion (32) to define a light confinement region in the slab and strip portions (32,34). A refractive index of the strip portion (34) is lower than a refractive index of the slab portion (32). The strip portion (34) is made out of a polymer material.

Classes IPC  ?

• G02B 6/125 - Courbures, branchements ou intersections

Abrégé

A resist composition for use in the fabrication of integrated circuits, the use of a resist composition, and a lithographic method utilising a resist composition, wherein the resist composition comprises an alkyltin-oxo cage having a counterion selected from tetrakis(pentafluorophenyl) borate, tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, tetrakis[3,5-bis(tert-butyl)phenyl]borate, and tetrakis[(3,5-bis(l,l,l,3,3,3-hexafluoro-2-methoxypropan-2-yl)phenyl)phenyl]borate. A lithographic method comprising the steps of: a) providing a resist composition comprising an alkyltin-oxo cage having a counterion selected from the above borate groups; b) exposing the resist composition to a patterned radiation beam or an electron beam to form a pattern in the resist composition; and c) developing the resist to form a circuit pattern.

Classes IPC  ?

• G03F 7/004 - Matériaux photosensibles

Abrégé

The invention relates to the use of a single heavy chain variable domain antibody against human cytomegalovirus protein US28, which antibody binds to the extracellular region including, for example, the N-terminal extracellular region and/or the extracellular loops of US28, for isolation of cells that are infected with cytomegalovirus and/or for ex vivo reactivation of cytomegalovirus in latently infected cells. The invention further relates to the anti-US28 antibody for use in a method of reactivating cytomegalovirus in infected cells, or in a method of eliminating infected cells. The invention further relates to a tissue, organ, or cells such as bone marrow stem cells, from which cells that were infected with CMV have been removed with the use of the anti-US28 antibody.

Classes IPC  ?

• C07K 16/08 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

The present invention relates to nucleic acid molecules comprising a target binding sequence complementary to a part of the STXBP1 mRNA sequence and an effector domain a SINE B2, which nucleic acid molecule can upregulate protein translation of the target STXBP1 mRNA. The invention further relates to expression constructs, such gene therapy vectors, for expression of the nucleic acid molecules of the invention, and to composition comprising the nucleic acid molecules and expression constructs of the invention. The invention further discloses methods wherein the nucleic acid molecules, expression constructs and compositions of the invention are used for compensation of STXBP1 haploinsufficiency in the prevention or treatment of STXBP1-related disorders.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C12N 15/67 - Méthodes générales pour favoriser l'expression

Abrégé

43211234112233444. The invention further relates to the use of said cyclic peptide as a medicament, especially for inhibiting or preventing a Wingless/integrase-1 (Wnt) -dependent disease in an individual in need thereof.

Classes IPC  ?

• C07K 7/54 - Peptides cycliques contenant au moins une liaison peptidique anormale comportant au moins une liaison peptidique anormale dans le cycle
• A61K 38/00 - Préparations médicinales contenant des peptides
• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés

Abrégé

The present disclosure relates to compounds of formula (I) comprising a heteroaryl, such as derivatives of quinazolines, which can act as modulators of ACKR3. The present disclosure also relates to the use of these compounds as a drug.

Classes IPC  ?

• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 239/95 - QuinazolinesQuinazolines hydrogénées avec des hétéro-atomes liés directement en positions 2 et 4
• C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• A61P 35/00 - Agents anticancéreux
• A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine

Abrégé

The invention relates to methods for tumor marker analysis comprising providing a genomic DNA sample from tumor cells of a patient, preselecting a chromosomal region on the genomic DNA comprising at least part of a potential structural variant (SV); and sequencing the genomic region to characterize the potential SV. The invention further relates to methods for detecting minimal residual disease, monitoring treatment response and tumor progression in a patient by employing the SV, and to personalized therapy based on the identity of the SV.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

Disclosed is a metrology apparatus and method for measurement of a diffractive structure on a substrate. The metrology apparatus comprises a radiation source operable to provide first radiation for excitation of the diffractive structure such that high harmonic second radiation is generated from said diffractive structure and/or substrate; and a detection arrangement operable to detect said second radiation, at least a portion of which having been diffracted by said diffractive structure.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• G01N 21/47 - Dispersion, c.-à-d. réflexion diffuse
• G01N 21/956 - Inspection de motifs sur la surface d'objets
• G01N 23/22 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en mesurant l'émission secondaire de matériaux

Abrégé

Disclosed is a metrology apparatus for measurement of a target formed on a substrate by a lithographic process and associated method. The metrology apparatus comprises a radiation source operable to provide first radiation; a configured solid high harmonic generation medium being configured to receive and be excited by said first radiation to generate high harmonic second radiation from an output surface of the configured solid high harmonic generation medium; and a detection arrangement operable to detect said second radiation, at least a portion of which having been scattered by said target. The configured solid high harmonic generation medium is configured to shape the beam of said second radiation and/or separate said first and second radiation.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• G02F 1/35 - Optique non linéaire
• H05G 2/00 - Appareils ou procédés spécialement adaptés à la production de rayons X, n'utilisant pas de tubes à rayons X, p. ex. utilisant la génération d'un plasma

Abrégé

The invention relates to the use of sphingosine-based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine-based compounds. Compositions comprising sphingosine-based compounds are also provided.

Classes IPC  ?

• A61K 8/55 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du phosphore
• A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
• A61C 13/08 - Dents artificiellesFabrication de dents artificielles
• A61K 8/24 - PhosphoreSes composés
• A61K 8/41 - Amines
• A61K 8/42 - Amides
• A61K 8/68 - Sphingolipides, p. ex. céramides, cérébrosides, gangliosides
• A61Q 11/00 - Préparations pour le nettoyage des dents, de la bouche ou des prothèses dentaires, p. ex. dentifricesBains de bouche
• A61Q 11/02 - Préparations pour désodoriser, décolorer ou désinfecter les prothèses dentaires

Abrégé

There is provided a training apparatus (20) comprising: a training implement (22) for receiving an impact; a plurality of acceleration sensors (36) arranged inside the training implement (22), each acceleration sensor (36) configured to, in use, measure an acceleration of the training implement (22) in response to an impact against the training implement (22); and a processing circuit programmed to process the measured acceleration by each acceleration sensor (36) so as to compute information about the impact against the training implement (22), wherein the computed information includes an orientation of the impact against the training implement (22).

Classes IPC  ?

• A63B 69/20 - Punching-balls
• A63B 24/00 - Commandes électriques ou électroniques pour les appareils d'exercice des groupes
• A63B 71/06 - Dispositifs indicateurs ou de marque pour jeux ou joueurs

Abrégé

There is provided an endoscopy instrument (20) for in-vivo characterisation of tissue. The endoscopy instrument (20) comprises: a probe (26) for insertion into a body orifice and probing the tissue through the body orifice; an actuator (30,32) operably coupled to the probe (26) so that the actuator (30,32) is operable to, through the probe (26), cause mechanical deformation of the tissue; and an imaging device (24) operably coupled to the probe (26) so that the imaging device (24) is operable to, through the probe (26), obtain an image of the mechanically deformed tissue.

Classes IPC  ?

• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
• A61B 1/015 - Commande de l'alimentation en fluide ou de l'évacuation de fluide
• A61B 1/05 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision caractérisés par le fait que le capteur d'images, p. ex. l'appareil photographique, est placé dans la partie de l'extrémité distale

Abrégé

Methods and systems for determining cell properties are described, wherein a method may comprise the steps of receiving images representing manipulating cellular bodies in a holding space, the holding space comprising a wall surface, the manipulating including exerting one or more force pulses to the cellular bodies provided on the wall surface, the force pulses having a direction away from the wall surface; analyzing the images, the analyzing including determining the size of the cellular bodies and tracking locations of the cellular bodies during each of the one or more force pulses and after each of the one or more force pulses, the tracking locations defining one or more first trajectories of the cellular bodies moving away from the wall surface and one or more trajectories of the cellular bodies moving towards the wall surface; determining densities of the cellular bodies based on the one or more second trajectories and a sedimentation model of the cellular bodies moving towards the wall surface and determining cellular body velocities based the one or more first trajectories and a velocity model of the cellular bodies moving away from the wall surface; and, determining a contrast factor for each of the cellular bodies based on the sizes and the densities of the cellular bodies, the force applied to the cellular bodies and the cellular body velocities and determining a compressibility for each of the cellular bodies based on the determined contrast factors.

Classes IPC  ?

• G01N 15/10 - Recherche de particules individuelles
• G01N 29/06 - Visualisation de l'intérieur, p. ex. microscopie acoustique
• G02B 21/32 - Micromanipulateurs combinés par construction avec des microscopes
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux

Abrégé

Disclosed is a wavefront sensor for measuring a wavefront of a radiation. The wavefront sensor comprises a mask comprising a pattern located in path of the radiation to interact with the radiation. The radiation impinging on the mask forms a radiation detection pattern on a radiation detector subsequent to the mask, and the pattern of the mask is designed at least partly based on a requirement of the radiation detection pattern.

Classes IPC  ?

• G01J 1/04 - Pièces optiques ou mécaniques
• G01J 1/42 - Photométrie, p. ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
• G01J 9/00 - Mesure du déphasage des rayons lumineuxRecherche du degré de cohérenceMesure de la longueur d'onde des rayons lumineux
• G03F 7/20 - ExpositionAppareillages à cet effet

Abrégé

There is provided a spectroscopy apparatus for measuring fluorescence signals from a photosynthetic object. The spectroscopy apparatus comprises: one or more light excitation sources (26,28) operable to carry out time- varying excitation of the fluorescence from the photosynthetic object; and one or more fluorescence-sensitive detection channels (36,38,44,46) configured to simultaneously record the fluorescence as a function of time with a microsecond to millisecond time resolution and as a function of wavelength with a wavelength resolution of 10 nm or better, responsive to the excitation of the fluorescence from the photosynthetic object by the or each light excitation source (26,28).

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
• G01N 21/84 - Systèmes spécialement adaptés à des applications particulières

Abrégé

An EUV radiation source comprising a fuel emitter configured to produce fuel droplets; a laser system configured to illuminate a fuel droplet at a plasma formation region, the laser system comprising: a first laser configured to produce radiation of a first wavelength in a first radiation beam, a second laser configured to produce radiation of a second wavelength in a second radiation beam, and a first parametric amplifier arranged to receive the radiation of the first wavelength and radiation of the second wavelength and generate an amplified radiation beam; and a beam delivery system for delivering the amplified radiation beam to the plasma formation region.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• H05G 2/00 - Appareils ou procédés spécialement adaptés à la production de rayons X, n'utilisant pas de tubes à rayons X, p. ex. utilisant la génération d'un plasma
• G02F 1/39 - Optique non linéaire pour la génération ou l'amplification paramétrique de la lumière, des infrarouges ou des ultraviolets

Abrégé

Methods and apparatus for forming a patterned layer of material are disclosed. In one arrangement, a deposition-process material is provided in gaseous form. A layer of the deposition-process material is formed on the substrate by causing condensation or deposition of the gaseous deposition-process material. A selected portion of the layer of deposition-process material is irradiated to modify the deposition-process material in the selected portion.

Classes IPC  ?

• C23C 16/04 - Revêtement de parties déterminées de la surface, p. ex. au moyen de masques
• C23C 16/26 - Dépôt uniquement de carbone
• C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction
• C23C 16/46 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour le chauffage du substrat
• C23C 16/48 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement par irradiation, p. ex. par photolyse, radiolyse ou rayonnement corpusculaire
• C23C 16/56 - Post-traitement
• C23C 14/04 - Revêtement de parties déterminées de la surface, p. ex. au moyen de masques
• H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
• G03F 7/004 - Matériaux photosensibles
• G03F 7/16 - Procédés de couchageAppareillages à cet effet
• G03F 7/36 - Dépouillement selon l'image non couvert par les groupes , p. ex. utilisant un courant gazeux, un plasma

Abrégé

A dark field digital holographic microscope is disclosed which is configured to determine a characteristic of interest of a structure. The dark field digital holographic microscope comprises an illumination device configured to provide at least: a first beam pair comprising a first illumination beam of radiation (1010) and a first reference beam of radiation (1030) and a second beam pair comprising a second illumination beam of radiation (1020) and a second reference beam of radiation (1040); and one or more optical elements (1070) operable to capture a first scattered radiation and to capture a second scattered radiation scattered by the structure resultant from the first and second illumination beams respectively. The beams of the first beam pair are mutually coherent and the beams of the second beam pair are mutually coherent. The illumination device is configured to impose incoherence (ADI) between the first beam pair and second beam pair.

Classes IPC  ?

• G03H 1/04 - Procédés ou appareils pour produire des hologrammes
• G03H 1/26 - Procédés ou appareils adaptés spécialement pour produire des hologrammes multiples ou pour en obtenir des images, p. ex. procédés pour l'holographie à plusieurs couleurs
• G03F 7/20 - ExpositionAppareillages à cet effet

Abrégé

Some embodiments are directed to secure communication with a server from a device. The device is configured to decrypt an encrypted message in a secure mode with a private key, and to display secret shared with the user together with the decrypted message on a display of the device to indicate to the user that the message is being displayed by software running in the secure mode.

Classes IPC  ?

• G06F 21/72 - Protection de composants spécifiques internes ou périphériques, où la protection d'un composant mène à la protection de tout le calculateur pour assurer la sécurité du calcul ou du traitement de l’information dans les circuits de cryptographie
• G06F 21/74 - Protection de composants spécifiques internes ou périphériques, où la protection d'un composant mène à la protection de tout le calculateur pour assurer la sécurité du calcul ou du traitement de l’information opérant en mode dual ou compartimenté, c.-à-d. avec au moins un mode sécurisé
• G06F 21/84 - Protection des dispositifs de saisie, d’affichage de données ou d’interconnexion dispositifs d’affichage, p. ex. écrans ou moniteurs
• G06F 21/31 - Authentification de l’utilisateur
• G06F 21/34 - Authentification de l’utilisateur impliquant l’utilisation de dispositifs externes supplémentaires, p. ex. clés électroniques ou cartes à puce intelligentes

Abrégé

The present invention relates to methods and cross-linkers for the macrocyclization of proteins. The invention is useful for increasing the stability of a protein.

Classes IPC  ?

• C12N 9/96 - Stabilisation d'une enzyme par formation d'un adduct ou d'une compositionFormation de conjugaisons d'enzymes
• C12N 9/52 - Protéinases provenant de bactéries
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

A broadband optical coupler (50) comprises a set of waveguides (10,20). Each waveguide comprises a respective curved starting sections (11,21) where the waveguides curve towards each other, straight middle sections (12,22) where light can couple between the waveguides, and ending sections where the waveguides curve away from each other. To increase bandwidth while maintaining a compact design, the straight middle sections (12,22) are disposed at a tangential offset (Y1) with respect to each other along a direction (Y) of their respective length (L2,L6). An optical switch (100) comprises at least two of such couplers connected in series. An optical device (1000) employs the switch or coupler in broadband applications such as optical coherence tomography (OCT).

Classes IPC  ?

• G02B 6/12 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
• G02B 6/122 - Éléments optiques de base, p. ex. voies de guidage de la lumière

Abrégé

Disclosed is a method for a metrology measurement on an area of a substrate comprising at least a portion of a target structure. The method comprises receiving a radiation information representing a portion of radiation scattered by the are, and using a filter in a Fourier domain for removing or suppressing at least a portion of the received radiation information that does not relate to radiation that has been scattered by the target structure for obtaining a filtered radiation information for the metrology measurement, wherein characteristics of the filter are based on target information about the target structure.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• G01N 21/956 - Inspection de motifs sur la surface d'objets

Abrégé

The invention relates to compounds and pharmaceutically acceptable salts thereof, and to their medical use. Exemplary medical uses are the prevention and treatment of a bacterial infection, for example, a mycobacterial infection, such as a Mycobacterium tuberculosis infection, e.g., in a respiratory system and/or extrapulmonic. The invention further relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds as chemotherapeutic agents. Also, the invention relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds for inhibiting mycobacterial type VII secretion. The compounds have the following formula (Ia), wherein Q and X are, respectively, CH and C, CR2and C, CH and N, CR2and N, or N and C; R1is hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms; R2is independently selected from hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms, and R3 is optionally substituted linear or branched alkoxy having 1-6 carbon atoms, haloalkyl having 1-6 carbon atoms, n-propyl, 2-propenyl, 2-propynyl, or n-pentyl, or a pharmaceutically acceptable salt of the compound, for use in the prevention or treatment of a bacterial infection.

Classes IPC  ?

• C07D 285/08 - Thiadiazoles-1, 2, 4Thiadiazoles-1, 2, 4 hydrogénés
• C07D 417/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• A61K 31/4436 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un hétérocycle avec le soufre comme hétéro-atome du cycle
• A61K 31/42 - Oxazoles
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/4245 - Oxadiazoles
• A61K 31/433 - Thiadiazoles
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61P 31/04 - Agents antibactériens
• A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose

Abrégé

The invention relates to the use of a single heavy chain variable domain antibody against human cytomegalovirus protein US28, which antibody binds to the extracellular region including, for example, the N-terminal extracellular region and/or the extracellular loops of US28, for isolation of cells that are infected with cytomegalovirus and/or for ex vivo reactivation of cytomegalovirus in latently infected cells. The invention further relates to the anti-US28 antibody for use in a method of reactivating cytomegalovirus in infected cells, or in a method of eliminating infected cells. The invention further relates to a tissue, organ, or cells such as bone marrow stem cells, from which cells that were infected with CMV have been removed with the use of the anti-US28 antibody.

Classes IPC  ?

• A61P 31/20 - Antiviraux pour le traitement des virus ADN
• C07K 16/08 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire

Abrégé

The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.

Classes IPC  ?

• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• C07K 16/08 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

a).

Classes IPC  ?

• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G02B 6/28 - Moyens de couplage optique ayant des bus de données, c.-à-d. plusieurs guides d'ondes interconnectés et assurant un système bidirectionnel par nature en mélangeant et divisant les signaux

Abrégé

A first aspect provides, in a device for processing biomedical data obtained from a body, a method of determining brain activity. The method comprises obtaining neuron oscillation signal data of a first part of a brain over a period of time. The oscillation signal data is apportioned in timeslots within the period and per time slot, based on the oscillation data for the timeslot, an amplitude value and variation value representing data values in the timeslot are obtained. A correlation value is determined between the amplitude values and the corresponding variation values over at least a substantial part of the first time period; and the correlation value is provided as an output. The correlation value may optionally be used for estimating a ratio between excitation and inhibition activity of the brain under scrutiny.

Classes IPC  ?

• A61B 5/04 - Mesure de signaux bioélectriques du corps ou de parties de celui-ci
• A61B 5/0476 - Electro-encéphalographie
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

Disclosed is a method of determining a complex-valued field relating to a structure, comprising: obtaining image data relating to a series of images of the structure, for which at least one measurement parameter is varied over the series and obtaining a trained network operable to map a series of images to a corresponding complex-valued field. The method comprises inputting the image data into said trained network and non-iteratively determining the complex-valued field relating to the structure as the output of the trained network. A method of training the trained network is also disclosed.

Classes IPC  ?

• G03F 1/84 - Inspection
• G01N 21/956 - Inspection de motifs sur la surface d'objets
• G03F 7/20 - ExpositionAppareillages à cet effet
• G06T 7/00 - Analyse d'image
• G03H 1/04 - Procédés ou appareils pour produire des hologrammes

Abrégé

System for photoacoustic spectroscopy, the system comprising: ° a light system comprising a light source, wherein the light system is configured to generate a light beam, to modulate the light beam at a modulation frequency, and to direct the light beam to a space; ° an optical waveguide, comprising a first measurement part; ° a vibration unit arranged in the space, comprising: ° a first fixation structure and a second fixation structure, wherein the first fixation structure and the second fixation structure are arranged remotely from each other in the space, and wherein the first measurement part of the optical waveguide is tightened between the first fixation structure and the second fixation structure, and wherein the first measurement part extends through the space and is in immediate contact with the space; ° a detection unit, configured to detect a first vibration of the first measurement part based on changes in optical propagation properties of the optical waveguide, the detection unit comprising: ° a sensor light source coupled to the optical waveguide, wherein the sensor light source is configured to generate a sensor light beam propagating through the optical waveguide; ° a sensor light detector coupled to the optical waveguide, wherein the sensor light detector is configured to measure the sensor light beam having propagated through the optical waveguide; ° a signal processing unit, configured to detect the first vibration of the first measurement part based on the generated sensor light beam and the measured sensor light beam.

Classes IPC  ?

• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
• G01H 9/00 - Mesure des vibrations mécaniques ou des ondes ultrasonores, sonores ou infrasonores en utilisant des moyens sensibles aux radiations, p. ex. des moyens optiques
• G01B 11/16 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la déformation dans un solide, p. ex. indicateur optique de déformation

Abrégé

An EUV radiation source of a laser-produced-plasma type, comprising: a fuel emitter configured to produce fuel droplets; and a laser system configured to illuminate a fuel droplet with radiation for converting the fuel droplet into a plasma at a plasma formation region; wherein the laser system comprises: a laser configured to produce radiation of a first wavelength; and a nonlinear medium configured to receive radiation of the first wavelength, produce radiation of a second wavelength using a nonlinear optical process at a radiation conversion region, and deliver radiation of the second wavelength to the plasma formation region; wherein the second wavelength is longer than the first wavelength.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• H05G 2/00 - Appareils ou procédés spécialement adaptés à la production de rayons X, n'utilisant pas de tubes à rayons X, p. ex. utilisant la génération d'un plasma

Abrégé

The present invention relates to a headphone for use with an audio or mobile communication device, comprising at least one earbud, a microphone, and a wire. The headphone further comprises a stiffening mechanism, which is constructed to be arranged in an actuated state, in which the stiffening mechanism has a first bending stiffness and in which the stiffening mechanism is in a stiff configuration, and in a relaxed state, in which the stiffening mechanism has a second bending stiffness and in which the stiffening mechanism is in a free-hanging configuration. The first bending stiffness is larger than the second bending stiffness. The invention further relates to a method for communicating by means of a headphone, which comprises the steps of arranging, at the onset of communication, a stiffening mechanism of the headphone in an actuated state, in order to position a microphone of the headphone in front of a mouth of the user, and arranging, at the end of communication, the stiffening mechanism in a relaxed state, in order to freely suspend the microphone.

Classes IPC  ?

• H04R 1/10 - ÉcouteursLeurs fixations
• H04R 1/08 - EmbouchuresLeurs fixations

Abrégé

An imaging system (100) comprises a multimode waveguide (Wm) configured to receive input light (Li) from a light source (20) into its proximal side (13p) and output a corresponding speckle pattern (Pn) based on the input light (Li) out of its distal side (13d) for illuminating a sample (S) to be imaged. A single -mode waveguide (Ws) is connected to the multimode waveguide (Wm) for coupling the input light (Li) from the light source (20) to the multimode waveguide (Wm). The multimode waveguide (Wm) has a relatively short length (Zm) and relatively high flexural rigidity (R) for maintaining a unique relation between the input characteristic (λ,Α) of the input light (Li) into the multimode waveguide (Wm) and a spatial distribution (Ixy) of the speckle pattern (Pn). The single-mode waveguide (Ws) may be relatively long and flexible (F) for allowing movement of the short rigid multimode waveguide (Wm).

Classes IPC  ?

• G01D 5/353 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens optiques, c.-à-d. utilisant de la lumière infrarouge, visible ou ultraviolette avec atténuation ou obturation complète ou partielle des rayons lumineux les rayons lumineux étant détectés par des cellules photo-électriques en modifiant les caractéristiques de transmission d'une fibre optique
• G01D 5/34 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens optiques, c.-à-d. utilisant de la lumière infrarouge, visible ou ultraviolette avec atténuation ou obturation complète ou partielle des rayons lumineux les rayons lumineux étant détectés par des cellules photo-électriques
• G01H 9/00 - Mesure des vibrations mécaniques ou des ondes ultrasonores, sonores ou infrasonores en utilisant des moyens sensibles aux radiations, p. ex. des moyens optiques
• G01L 1/24 - Mesure des forces ou des contraintes, en général en mesurant les variations des propriétés optiques du matériau quand il est soumis à une contrainte, p. ex. par l'analyse des contraintes par photo-élasticité
• G02B 27/48 - Systèmes optiques utilisant la granulation produite par laser
• F21V 8/00 - Utilisation de guides de lumière, p. ex. dispositifs à fibres optiques, dans les dispositifs ou systèmes d'éclairage
• A61B 1/07 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement utilisant des moyens conduisant la lumière, p. ex. des fibres optiques
• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
• G02B 6/036 - Fibres optiques avec revêtement le noyau ou le revêtement comprenant des couches multiples
• G01N 21/47 - Dispersion, c.-à-d. réflexion diffuse

Abrégé

System for training a sports player, including: -a portable light transmission adjuster (1) configured to control transmission of ambient light to at least one eye of a user when carrying said light transmission adjuster (1); -a detector (10) configured to detect a presence of the user at a predetermined position with respect to a sports attribute (T); and -a controller (5), communicatively connectable to the detector (10), the controller (5) being configured to switch the light transmission adjuster (1) from a low light transmission state to a high light transmission state based on a positive detection result of the detector (10). The invention also provides a method for training a sports player.

Classes IPC  ?

• A63B 69/00 - Appareils d'entraînement ou appareils destinés à des sports particuliers
• A63B 71/06 - Dispositifs indicateurs ou de marque pour jeux ou joueurs
• G02C 7/00 - Pièces optiques
• A63B 24/00 - Commandes électriques ou électroniques pour les appareils d'exercice des groupes
• A63B 102/02 - Tennis

Abrégé

Disclosed is a method for obtaining a computationally determined interference electric field describing scattering of radiation by a pair of structures comprising a first structure and a second structure on a substrate. The method comprises determining a first electric field relating to first radiation scattered by the first structure; determining a second electric field relating to second radiation scattered by the second structure; and computationally determining the interference of the first electric field and second electric field, to obtain a computationally determined interference electric field.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet

Abrégé

A method for probing mechanical properties of cellular bodies includes: providing a plurality of particles in a fluid medium contained in a holding space of a sample holder, each of the plurality of particle being attached to a cellular body; generating a resonant bulk acoustic wave in the holding space, the resonant bulk acoustic wave exerting an acoustic force on each of the plurality of particles, each of the plurality of particles having an acoustic contrast factor and a size, the acoustic contrast factor and the size being selected such that the force exerted on a particle is larger than the force exerted on the cellular body to which the particle is attached; measuring a displacement of a particle in response to the exertion of the force on the particle, the measured displacement being associated with a mechanical property of the cellular body attached to the particle.

Classes IPC  ?

• G01N 29/06 - Visualisation de l'intérieur, p. ex. microscopie acoustique
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

The present invention relates to methods and cross-linkers for the macrocyclization of proteins. The invention is useful for increasing the stability of a protein.

Classes IPC  ?

• C12N 9/96 - Stabilisation d'une enzyme par formation d'un adduct ou d'une compositionFormation de conjugaisons d'enzymes
• C12N 9/52 - Protéinases provenant de bactéries
• C12N 9/64 - Protéinases provenant de tissu animal, p. ex. rennine

Abrégé

Methods and apparatus are disclosed for determining a characteristic of a structure. In one arrangement, the structure is illuminated with first illumination radiation to generate first scattered radiation. A first interference pattern is formed by interference between a portion of the first scattered radiation reaching a sensor and first reference radiation. The structure is also illuminated with second illumination radiation from a different direction. A second interference pattern is formed using second reference radiation. The first and second interference patterns are used to determine the characteristic of the structure. Azimuthal angles of the first and second reference radiations onto the sensor are different.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet

Abrégé

A fibre endoscope system (100) comprises a catheter (10) with a probe head (10a) for entering into a body cavity (C) adjacent or near a sample region (S). A source fiber (11) has a first fiber ending (11a) and a signal fiber (12) has a second fiber ending (12a) both remote from the probe head (10a) but separate. A sampling fiber (13) has a third fiber ending (13a) disposed at the probe head (10a). A fiber coupler (15) is configured to optically couple at least the source fiber (11) to the sampling fiber (13), and the sampling fiber (13) to the signal fiber (12). A sampling fiber length (L13) of the sampling fiber (13) between a fiber coupler (15) and the third fiber ending (13a) is shorter than a source fiber length (L11) of the source fiber (11) between the fiber coupler (15) and the first fiber ending (11a).

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G02B 6/26 - Moyens de couplage optique
• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments

Abrégé

A first aspect provides, in a device for processing biomedical data obtained from a body, a method of determining brain activity. The method comprises obtaining neuron oscillation signal data of a first part of a brain over a period of time. The oscillation signal data is apportioned in timeslots within the period and per time slot, based on the oscillation data for the timeslot, an amplitude value and variation value representing data values in the timeslot are obtained. A correlation value is determined between the amplitude values and the corresponding variation values over at least a substantial part of the first time period; and the correlation value is provided as an output. The correlation value may optionally be used for estimating a ratio between excitation and inhibition activity of the brain under scrutiny.

Classes IPC  ?

• A61B 5/0476 - Electro-encéphalographie
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique

Abrégé

Disclosed is a method and associated apparatus for measuring a characteristic of interest relating to a structure on a substrate. The method comprises calculating a value for the characteristic of interest directly from the effect of the characteristic of interest on at least the phase of illuminating radiation when scattered by the structure, subsequent to illuminating said structure with said illuminating radiation.

Classes IPC  ?

• G02B 27/42 - Optique de diffraction
• G03F 7/20 - ExpositionAppareillages à cet effet
• G03H 1/04 - Procédés ou appareils pour produire des hologrammes
• G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques

Abrégé

A radiation source (SO) of a laser-produced plasma type is described. The radiation source (SO) comprises a droplet generator (3a) configured to provide a fuel droplet (60). The radiation source (SO) comprises a laser system (1) configured to provide a pre-pulse and a main-pulse. The pre-pulse is operative to condition the fuel droplet (60) for receipt of main pulse. The main pulse is operative to convert the conditioned fuel droplet (60) into plasma. The radiation source (SO) comprises a sensing system (16) configured for sensing a characteristic of an oscillation of a spatial mass distribution of the fuel droplet (60). The radiation source (SO) comprises a control system (44) operative to adjust a polarization of the pre-pulse under control of the sensed characteristic. The polarization of the pre- pulse may affect the spatial mass distribution of the conditioned fuel droplet (60).

Classes IPC  ?

• H05G 2/00 - Appareils ou procédés spécialement adaptés à la production de rayons X, n'utilisant pas de tubes à rayons X, p. ex. utilisant la génération d'un plasma

Abrégé

Methods and apparatus for forming a patterned layer of carbon are disclosed. In one arrangement, a selected portion of a surface of a solid structure is irradiated with extreme ultraviolet radiation in the presence of a carbon-containing precursor. The radiation interacts with the solid structure in the selected portion to cause formation of a layer of carbon in the selected portion from the carbon-containing precursor. The layer of carbon is formed in a pattern defined by the selected portion.

Classes IPC  ?

• C23C 16/04 - Revêtement de parties déterminées de la surface, p. ex. au moyen de masques
• C23C 16/26 - Dépôt uniquement de carbone
• C23C 16/48 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement par irradiation, p. ex. par photolyse, radiolyse ou rayonnement corpusculaire
• C23C 16/56 - Post-traitement

Abrégé

The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/22 - Antiviraux pour le traitement des virus ADN des virus de l'herpès
• A61P 35/00 - Agents anticancéreux

Abrégé

One aspect of this disclosure relates to a method for determining a presence of at least one guest structure at a host structure. The method comprises a light-sensitive system receiving light from the host structure. The host structure hosts one or more optically active entities at at least one part of the host structure. Herein, the at least one part does not host the at least one guest structure. Furthermore, the optically active entities cause light emission from said at least one part. The method also comprises the light-sensitive system outputting a signal based on the received light. The method further comprises determining a light value based on the output signal. The light value indicates an amount of light from the host structure being incident on the light- sensitive system. The method also comprises determining on the basis of the light value at least one of a quantity and a position of the at least one guest structure at the host structure.

Classes IPC  ?

• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées

Abrégé

The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.

Classes IPC  ?

• C07K 16/08 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus
• A61P 35/00 - Agents anticancéreux
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/22 - Antiviraux pour le traitement des virus ADN des virus de l'herpès

Abrégé

Methods and systems for measuring retinal oxygenation. A retinal tissue with blood vessels is illuminated by light essentially consisting of a selection of two or more discrete wavelengths. Measurements are collected of a plurality of backscattered reflection intensities. The measurements are spectrally resolved for the selection of discrete wavelengths and position-resolved for at least a blood vessel location coinciding with a selected blood vessel and a tissue location coinciding with the retinal tissue without blood vessel. The oxygenation is calculated based on the measurements. The calculation includes an analytical model describing a dependence of the intensities on the oxygenation of blood in the selected blood vessel and a size of the selected blood vessel. For example, a pigment packaging effect is included in the model leading to optimum wavelengths at which the error is minimized.

Classes IPC  ?

• A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale

Abrégé

A method for supercoiling DNA, e.g. negatively supercoiling DNA, is disclosed. In an initial state, at least part of a DNA molecule is torsionally constrained and associated with a first linking number. The at least part of the DNA molecule has a first end connected to a first body and a second end connected to a second body. The method comprises increasing a distance between the first body and the second body for inducing a torque in the at least part of the DNA molecule and for bringing the at least part of the DNA molecule from the initial state into an intermediate state. In the intermediate state the at least part of the DNA molecule is temporarily torsionally unconstrained for at least partially releasing the induced torque for changing, e.g. decreasing, the first linking number. The method further comprises decreasing the distance between the first and second body for bringing the at least part of the DNA molecule from the intermediate state into a further state in which the at least part of the DNA molecule is torsionally constrained and associated with a second linking number different from the first linking number.

Classes IPC  ?

• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
• A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester

Abrégé

One aspect of this disclosure relates to a computer- implemented method for determining a force acting on at least part of a structure, for example a biological structure, such as a DNA molecule. The method comprises controlling a light- sensitive system, e.g. of a microscope, to determine light information based on light from the structure. The light is incident on at least a part of the light sensitive system. The light-sensitive system may be said to capture the light from the structure. The at least part of the structure comprises one or more optically active entities, such as DNA intercalator molecules and donor/acceptor fluorophores. At least one of (i) an optical activity of the entities and (ii) a quantity of the entities depends on the force acting on the at least part of the structure. Furthermore, the light information defines a light property value associated with said at least part of the structure. The method further comprises determining the force acting on the at least part of the structure on the basis of said light property value and a reference light property value.

Classes IPC  ?

• G01L 1/24 - Mesure des forces ou des contraintes, en général en mesurant les variations des propriétés optiques du matériau quand il est soumis à une contrainte, p. ex. par l'analyse des contraintes par photo-élasticité
• G02B 21/00 - Microscopes
• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux

Abrégé

Described is a metrology system for determining a characteristic of interest relating to at least one structure on a substrate, and associated method. The metrology system comprises a processor being configured to computationally determine phase and amplitude information from a detected characteristic of scattered radiation having been reflected or scattered by the at least one structure as a result of illumination of said at least one structure with illumination radiation in a measurement acquisition, and use the determined phase and amplitude to determine the characteristic of interest.

Classes IPC  ?

• G01B 11/24 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer des contours ou des courbes
• G03F 7/20 - ExpositionAppareillages à cet effet

Abrégé

A method for determining a characteristic of a feature in an object, the feature being disposed below a surface of the object is disclosed. The surface of the object is irradiated with a pulsed pump radiation beam so as to produce an acoustic wave in the object. The surface of the object is then irradiated with a measurement radiation beam. A portion of the measurement radiation beam scattered from the surface is received and a characteristic of the feature in the object is determined from at least a portion of the measurement radiation beam scattered from the surface within a measurement time period. A temporal intensity distribution of the pulsed pump radiation beam is selected such that in the measurement time period a signal to background ratio is greater than a signal to background ratio achieved using a single pulse of the pulsed pump radiation beam. The signal to background ratio is a ratio of: (a) signals generated at the surface by reflections of acoustic waves from the feature to (b) background signals generated at the surface by reflections of acoustic waves which have not reflected from the feature.

Classes IPC  ?

• G03F 9/00 - Mise en registre ou positionnement d'originaux, de masques, de trames, de feuilles photographiques, de surfaces texturées, p. ex. automatique

Abrégé

A metrology apparatus (302) includes a higher harmonic generation (HHG) radiation source for generating (310) EUV radiation. Operation of the HHG source is monitored using a wavefront sensor (420) which comprises an aperture array (424, 702) and an image sensor (426). A grating (706) disperses the radiation passing through each aperture so that the image detector captures positions and intensities of higher diffraction orders for different spectral components and different locations across the beam. In this way, the wavefront sensor can be arranged to measure a wavefront tilt for multiple harmonics at each location in said array. In one embodiment, the apertures are divided into two subsets (A) and (B), the gratings (706) of each subset having a different direction of dispersion. The spectrally resolved wavefront information (430) is used in feedback control (432) to stabilize operation of the HGG source, and/or to improve accuracy of metrology results.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• G01J 9/00 - Mesure du déphasage des rayons lumineuxRecherche du degré de cohérenceMesure de la longueur d'onde des rayons lumineux

Abrégé

A lithographic apparatus is a machine that applies a desired pattern onto a substrate, usually onto a target portion of the substrate. As increasing numbers of layers, using increasing numbers of specific materials, are deposited on substrates, it becomes increasingly difficult to detect alignment marks accurately, in part due to one or more of the materials used in one or more of the layers being wholly or partially opaque to the radiation used to detect alignment marks. In a first step, the substrate is illuminated with excitation radiation. In a second step, at least one effect associated with a reflected material effect scattered by a buried structure is measured in a suitable fashion. The effect may in an example comprise a physical displacement of the surface of the substrate. In a third step, at least one characteristic of the structure based on the measured effect is derived.

Classes IPC  ?

• G01B 11/24 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer des contours ou des courbes
• G03F 9/00 - Mise en registre ou positionnement d'originaux, de masques, de trames, de feuilles photographiques, de surfaces texturées, p. ex. automatique
• G01B 17/06 - Dispositions pour la mesure caractérisées par l'utilisation de vibrations infrasonores, sonores ou ultrasonores pour mesurer des contours ou des courbes

Abrégé

An EUV radiation source (42, 300) is used for example in a lithographic apparatus or inspection apparatus. For generating EUV radiation (302), laser radiation (304) in a second waveband is directed to a target of liquid tin fuel (69) to cause generation of a plasma. Grating radiation (328) is delivered to the target prior to and/or during delivery of the laser radiation (304), producing an electromagnetic field having a spatial distribution that includes multiple peaks and troughs across the target (406). This causes a corresponding spatial variation in a property of the target, such as the refractive index. If high enough in energy, or it may cause ablation or plasma formation in a grating pattern. By one or more mechanisms, such as surface plasmon polaritons, this periodic variation in the optical properties of the target enhances absorption of the laser energy to improve conversion efficiency of the radiation source apparatus.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• H05G 2/00 - Appareils ou procédés spécialement adaptés à la production de rayons X, n'utilisant pas de tubes à rayons X, p. ex. utilisant la génération d'un plasma

Abrégé

The invention relates to biomarkers and diagnostic methods for determining the presence and/or risk of cerebral amyloid angiopathy (CAA) as well as to methods for screening for treatments for CAA.

Classes IPC  ?

• A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

In an inspection apparatus, a target on the surface is illuminated with illuminating radiation that comprises first and second illuminating components. The illuminating components form one or more periodic illuminating patterns on the surface. A plurality of scattered radiation patterns formed by the illuminating radiation after scattering by the target is captured at a detector for a number of values of a controllable characteristic of at least one of the illuminating components. The captured radiation is then used to reconstruct data describing the target.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• G02B 21/16 - Microscopes adaptés pour éclairage ultraviolet
• G01N 21/47 - Dispersion, c.-à-d. réflexion diffuse

Abrégé

A multilayer reflector for use in EUV lithography, for example, comprises alternating layers of Mo and RbxSiy. The RbxSiy and Mo interface is thermodynamically stable, reducing intermingling of the layers and preventing reduction in reflectivity. The RbxSiy layer can be hydrogenated to form RbSiH3. For the case of Mo/RbSiH3 an interlayer of RbH between Mo and RbSiH3 layers can be used. An Mo/RbH multilayer mirror is also useful.

Classes IPC  ?

• G03F 7/20 - ExpositionAppareillages à cet effet
• G03F 1/24 - Masques en réflexionLeur préparation
• G02B 5/08 - Miroirs
• G21K 1/06 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant la diffraction, la réfraction ou la réflexion, p. ex. monochromateurs

Abrégé

The present disclosure relates to an apparatus (100) and method for controlling a plurality of simultaneously active optical traps (OT1,OT2,OT3). In one method, trapping beams (TB1,TB2,TB3) are provided and redirected for individually controlling a respective position (X,Y) of optical traps (OT1,OT2,OT3) formed by focusing of the redirected trapping beams in a sample volume (SV). Light (L11,L20) from the sample volume (SV) corresponding to the optical traps is received. A path of a detector beam (AB) is overlapped with one of the trapping beams (TB3), wherein the detector beam has a distinct wavelength (λA) from that of the overlapping trapping beam (TB3). In one channel, the light from the sample volume is filtered according to wavelength, and only the filtered light having the wavelength (λA) of the detector beam (AB) is measured.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• G02B 21/32 - Micromanipulateurs combinés par construction avec des microscopes

Produits et services

Computer software; computer hardware; data processing equipment; apparatus and media for the input, output, storage, retrievel, processing, communication and display of data and information; compact discs; CD-Roms, audio, video and cinematographic apparatus and recordings; non printed publications. Printed material and publications; books, manuals, newsletters, magazines, periodicals; Educational and instructional material; stationery. Organisation of conferences and courses; educational and training services; Information services relating to any of the foregoing services; publishing services; editorial services including electronic editorial services; providing facilities for conferences, seminars, courses and exhibitions; information relating to education, provided on-line from the Internet.