Methods for removing a biomaterial implant and reversing occlusive effects of the biomaterial implant are described. In particular, methods for performing removal of biomaterial implants without damage to a body lumen where the biomaterial was previously implanted are presented. More specifically, methods of reversing an implant within a vas deferens are described.
Compositions, devices, and methods of using one or more hydrogel for contraception are disclosed. In embodiments, the compositions and devices comprise one or more contrast agent, rendering the compositions and devices radiopaque. Included are compositions for an occlusive implant comprising; a multi-arm polyethylene glycol terminated with a thiol crosslinked with a multi-arm polyethylene glycol terminated with a maleimide; and one or more contrast agent. The devices/hydrogel may be used for occlusion of a bodily duct, such as the vas deferens and/or fallopian tubes, for male and female contraception, respectively.
Delivery systems and methods for delivering a composition are described herein. In particular, apparatus and methods for performing controlled delivery of the composition via a delivery system that includes a delivery device and a cartridge assembly are described. The interface between the delivery device and the cartridge assembly maintains a supported container in a fixed longitudinal position relative to the delivery device and the composition is precisely dispensed from the container in response to an actuation of the delivery device.
Methods for removing a biomaterial implant and reversing occlusive effects of the biomaterial implant are described. In particular, methods for performing removal of biomaterial implants without damage to a body lumen where the biomaterial was previously implanted are presented. More specifically, methods of reversing an implant within a vas deferens using an ablation device are described.
Delivery systems, compositions, and methods for forming and delivering biomaterials from two components are described. Specifically, a composition includes a first component and a second component that are each formulated to be crosslinked with the other to form a hydrogel. The first component and the second component are formulated to have an initial storage modulus (initial G) and an initial loss modulus (initial G″) when initially combined such that a ratio of the initial G″ to the initial G is between about 5 and about 100. The first component and the second component are formulated to have a gelation storage modulus (gelation G) and a gelation loss modulus (gelation G″) at a gelation time after the first component and the second component are combined such that a atio of the gelation G″ to the gelation G is less than about 1. The gelation time is less than about 120 seconds.
A61F 6/22 - Obturateurs du canal déférent; Obturateurs des trompes de Fallope implantables dans le canal ou dans les oviductes
A61M 5/19 - Seringues avec plusieurs compartiments
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61F 6/00 - Dispositifs de contraception; Pessaires; Dispositifs pour les introduire
Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 μL-1,000 μL) of volume.
A61F 6/00 - Dispositifs de contraception; Pessaires; Dispositifs pour les introduire
A61F 6/22 - Obturateurs du canal déférent; Obturateurs des trompes de Fallope implantables dans le canal ou dans les oviductes
A61M 5/14 - Dispositifs de perfusion, p.ex. perfusion par gravité; Perfusion sanguine; Accessoires à cet effet
A61M 5/145 - Perfusion sous pression, p.ex. utilisant des pompes utilisant des réservoirs sous pression, p.ex. au moyen de pistons
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p.ex. compteurs de goutte-à-goutte
Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 μL-1,000 μL) of volume.
A61F 6/22 - Obturateurs du canal déférent; Obturateurs des trompes de Fallope implantables dans le canal ou dans les oviductes
A61F 6/00 - Dispositifs de contraception; Pessaires; Dispositifs pour les introduire
A61M 5/14 - Dispositifs de perfusion, p.ex. perfusion par gravité; Perfusion sanguine; Accessoires à cet effet
A61M 5/145 - Perfusion sous pression, p.ex. utilisant des pompes utilisant des réservoirs sous pression, p.ex. au moyen de pistons
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p.ex. compteurs de goutte-à-goutte
Compositions, devices and methods of using one or more hydrogel for contraception as well as localized, sustained delivery of drugs are disclosed. Device (e.g., hydrogel) embodiments are easily injectable, have a quick gelation rate, are highly durable, and are capable of lasting greater than 3 months in vivo. The devices/hydrogel may be used for occlusion of a bodily duct, such as the vas deferens and/or fallopian tubes, for male and female contraception, respectively. Once implanted, the device/hydrogel is able to release one or more drugs, such as small molecules or biologics, indirectly, systemically, and/or directly to the site of interest over a sustained period of time, such as for prevention and/or treatment of STIs.
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p.ex. PEG, PPG, PEO ou polyglycérol
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/568 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p.ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p.ex. androstane, testostérone
A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p.ex. phosphate de pyridoxal
Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 μL-1,000 μL) of volume.
A61F 6/00 - Dispositifs de contraception; Pessaires; Dispositifs pour les introduire
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p.ex. compteurs de goutte-à-goutte
A61F 6/22 - Obturateurs du canal déférent; Obturateurs des trompes de Fallope implantables dans le canal ou dans les oviductes
A61M 5/145 - Perfusion sous pression, p.ex. utilisant des pompes utilisant des réservoirs sous pression, p.ex. au moyen de pistons
Systems and methods for imaging an object that are capable of capturing an image or images of the object using an imaging modality, automatically detecting and analyzing the image or images by way of converting the image or images to at least one binary image, and analyzing the at least one binary image to extract and/or segment regions-of-interest (ROIs) from the at least one binary image. The object can be or include an implantation, occlusion, medical device, body lumen, tissue, organ, duct, and/or vessel. The imaging modality can be or include X-ray, CT, MRI, PET, and/or ultrasound, or any combination thereof. Also included are compositions of soft, implantable materials with one or more carbon-based material, nanomaterial, and/or allotrope present in an amount sufficient as an ultrasound contrast agent effective for days, months, or years and which compositions are useful in the automated imaging methods of the invention.
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
G06T 7/194 - Découpage; Détection de bords impliquant une segmentation premier plan-arrière-plan
A61L 31/18 - Matériaux au moins partiellement opaques aux rayons X ou au laser
G06T 7/136 - Découpage; Détection de bords impliquant un seuillage
A61L 31/12 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
G06T 7/155 - Découpage; Détection de bords impliquant des opérateurs morphologiques
A61L 27/44 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
11.
SYSTEMS AND METHODS FOR REMOVING BIOMATERIAL IMPLANTS
Methods for removing a biomaterial implant and reversing occlusive effects of the biomaterial implant are described. In particular, methods for performing removal of biomaterial implants without damage to a body lumen where the biomaterial was previously implanted are presented. More specifically, methods of reversing an implant within a vas deferens using an ablation device are described.
Delivery systems, compositions, and methods for forming and delivering biomaterials from two components are described. Specifically, a composition includes a first component and a second component that are each formulated to be crosslinked with the other to form a hydrogel. The first component and the second component are formulated to have an initial storage modulus (initial G') and an initial loss modulus (initial G'') when initially combined such that a ratio of the initial G'' to the initial G' is between about 5 and about 100. The first component and the second component are formulated to have a gelation storage modulus (gelation G') and a gelation loss modulus (gelation G'') at a gelation time after the first component and the second component are combined such that a ratio of the gelation G'' to the gelation G' is less than about 1. The gelation time is less than about 120 seconds.
Delivery systems, compositions, and methods for forming and delivering biomaterials from two components are described. Specifically, a composition includes a first component and a second component that are each formulated to be crosslinked with the other to form a hydrogel. The first component and the second component are formulated to have an initial storage modulus (initial G') and an initial loss modulus (initial G'') when initially combined such that a ratio of the initial G'' to the initial G' is between about 5 and about 100. The first component and the second component are formulated to have a gelation storage modulus (gelation G') and a gelation loss modulus (gelation G'') at a gelation time after the first component and the second component are combined such that a ratio of the gelation G'' to the gelation G' is less than about 1. The gelation time is less than about 120 seconds.
e.g.in vivoin vivo. The devices/hydrogel may be used for occlusion of a bodily duct, such as the vas deferens and/or fallopian tubes, for male and female contraception, respectively. Once implanted, the device/hydrogel is able to release one or more drugs, such as small molecules or biologies, indirectly, systemically, and/or directly to the site of interest over a sustained period of time, such as for prevention and/or treatment of STIs.
Described are methods for reversible occlusion of a body lumen by way of degradation as a result of exposure to one or more stimuli such as light. The methods include administering one or more substance(s) into a body lumen of a subject and forming a stimuli-responsive polymer mass in the body lumen from the one or more substance(s). The mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen and is susceptible to on-command reversal in the body lumen upon exposure to one or more stimuli. The methods include administering one or more stimuli to a polymer mass in a body lumen for a time and intensity to cause the reverse the polymer mass. The methods are particular useful for applications in which it is desirable to temporarily occlude a body lumen, such as male and female contraception.
A61B 18/24 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p.ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p.ex. d'une fibre optique; Pièces à main à cet effet avec un cathéter
A61F 6/22 - Obturateurs du canal déférent; Obturateurs des trompes de Fallope implantables dans le canal ou dans les oviductes
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL - 1 mL (or 1 µL - 1,000 µL) of volume.
A61M 5/14 - Dispositifs de perfusion, p.ex. perfusion par gravité; Perfusion sanguine; Accessoires à cet effet
A61M 5/19 - Seringues avec plusieurs compartiments
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL - 1 mL (or 1 µL - 1,000 µL) of volume.
A61M 5/14 - Dispositifs de perfusion, p.ex. perfusion par gravité; Perfusion sanguine; Accessoires à cet effet
A61M 5/19 - Seringues avec plusieurs compartiments
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 μL-1,000 μL) of volume.
A61F 6/22 - Obturateurs du canal déférent; Obturateurs des trompes de Fallope implantables dans le canal ou dans les oviductes
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p.ex. compteurs de goutte-à-goutte
A61F 6/00 - Dispositifs de contraception; Pessaires; Dispositifs pour les introduire
A61M 5/145 - Perfusion sous pression, p.ex. utilisant des pompes utilisant des réservoirs sous pression, p.ex. au moyen de pistons
Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 μL-1,000 μL) of volume.
A61F 6/00 - Dispositifs de contraception; Pessaires; Dispositifs pour les introduire
A61F 6/22 - Obturateurs du canal déférent; Obturateurs des trompes de Fallope implantables dans le canal ou dans les oviductes
A61M 5/145 - Perfusion sous pression, p.ex. utilisant des pompes utilisant des réservoirs sous pression, p.ex. au moyen de pistons
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p.ex. compteurs de goutte-à-goutte
An apparatus, system or device and methods for applying one or more stimuli to an implantation, occlusive device, or embolization are described. The implantation can include a polymer or polymer composition such as a hydrogel and can be used for sterilizing a subject in need of contraception by occluding the vas deferens, fallopian tube(s), or uterus, but can also be used to occlude, in whole or part, any other body ducts or organs. The one or more stimuli can modify the occlusion so that is removed from the body lumen in situ, there by reversing the contraception or other effects of the occlusion.
A61B 18/20 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p.ex. de micro-ondes en utilisant des lasers
21.
METHODS AND APPARATUS FOR DELIVERING A STIMULUS TO AN OCCLUSIVE IMPLANT
A61B 18/20 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p.ex. de micro-ondes en utilisant des lasers
Described are methods for reversible occlusion of a body lumen by way of degradation as a result of exposure to one or more stimuli such as light. The methods include administering one or more substance(s) into a body lumen of a subject and forming a stimuli-responsive polymer mass in the body lumen from the one or more substance(s). The mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen and is susceptible to on-command reversal in the body lumen upon exposure to one or more stimuli. The methods include administering one or more stimuli to a polymer mass in a body lumen for a time and intensity to cause the reverse the polymer mass. The methods are particular useful for applications in which it is desirable to temporarily occlude a body lumen, such as male and female contraception.
A61F 6/20 - Obturateurs du canal déférent; Obturateurs des trompes de Fallope
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
A61B 18/24 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p.ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p.ex. d'une fibre optique; Pièces à main à cet effet avec un cathéter
23.
METHODS FOR IMPLANTING AND REVERSING STIMULI-RESPONSIVE IMPLANTS
Described are methods for reversible occlusion of a body lumen by way of degradation as a result of exposure to one or more stimuli such as light. The methods include administering one or more substance(s) into a body lumen of a subject and forming a stimuli -responsive polymer mass in the body lumen from the one or more substance(s). The mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen and is susceptible to on-command reversal in the body lumen upon exposure to one or more stimuli. The methods include administering one or more stimuli to a polymer mass in a body lumen for a time and intensity to cause the reverse the polymer mass. The methods are particular useful for applications in which it is desirable to temporarily occlude a body lumen, such as male and female contraception.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
A61F 2/01 - Filtres implantables dans les vaisseaux sanguins
Described are methods for reversible occlusion of a body lumen by way of degradation as a result of exposure to one or more stimuli such as light. The methods include administering one or more substance(s) into a body lumen of a subject and forming a stimuli-responsive polymer mass in the body lumen from the one or more substance(s). The mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen and is susceptible to on-command reversal in the body lumen upon exposure to one or more stimuli. The methods include administering one or more stimuli to a polymer mass in a body lumen for a time and intensity to cause the reverse the polymer mass. The methods are particular useful for applications in which it is desirable to temporarily occlude a body lumen, such as male and female contraception.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
A61F 2/01 - Filtres implantables dans les vaisseaux sanguins
Described are methods for reversible occlusion of a body lumen by way of degradation as a result of exposure to one or more stimuli such as light. The methods include administering one or more substance(s) into a body lumen of a subject and forming a stimuli-responsive polymer mass in the body lumen from the one or more substance(s). The mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen and is susceptible to on-command reversal in the body lumen upon exposure to one or more stimuli. The methods include administering one or more stimuli to a polymer mass in a body lumen for a time and intensity to cause the reverse the polymer mass. The methods are particular useful for applications in which it is desirable to temporarily occlude a body lumen, such as male and female contraception.
A61F 6/20 - Obturateurs du canal déférent; Obturateurs des trompes de Fallope
A61B 18/24 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p.ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p.ex. d'une fibre optique; Pièces à main à cet effet avec un cathéter
A61F 6/22 - Obturateurs du canal déférent; Obturateurs des trompes de Fallope implantables dans le canal ou dans les oviductes
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
brevets
