Abrégé

The present invention provides affinity matured recombinant monoclonal antibodies (mAbs) and fragments that bind specifically to an HLA-E-peptide complex, including HLA-E-VL9 complexes, and. regulate the cytotoxicity effector cell function of NK and/or CD8+ T-cells positive for cell-surface expression of NKG2A (“NKG2A+”). Herein, monoclonal antibodies were recombinant.lv derived from isolated functional HLA-E-VL9-specific mAbs from HLA-E-VL9 peptide-immunized HLA-B transgenic mice and from the naive human B cell repertoire. Such antibodies are capable of regulating effector cell cytotoxicity' and can preferentially recognize HLA-E-VL9 peptide complexes expressed on the surface of tumor cells. The monoclonal antibodies were subject to one or more rounds of affinity 7 maturation. The invention provides methods for using affinity matured HLA-E-VL9 mAbs to modulate NK and/or CD8+T-cell function as part of immunotherapeutic strategies.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present invention relates to methods of modulating reprogramming, comprising increasing, enhancing and/or promoting the activity of peptidylarginine deiminase 4 (PADI4) enzyme, such as wherein the reprogramming of a somatic cell to a pluripotent-like state is increased, enhanced and/or promoted. The invention further relates to activators of PADI4, in particular activators which allosterically bind to PADI4, as well as their use in methods of reprogramming somatic cells and pharmaceutical compositions comprising said activators. Also provided is the pharmaceutical composition for use in treatment, rejuvenation, regeneration and repair.

Classes IPC  ?

• C12N 5/074 - Cellules souches adultes
• C12N 9/78 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5)

Abrégé

This disclosure describes novel biomarkers for use in cancer treatment and predicting responsiveness to a cancer therapy.

Classes IPC  ?

• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer

Abrégé

The present invention relates to an isolated polynucleotide comprising a sequence that is complementary to a non-coding region of a target gene or of a long non-coding RNA, wherein the isolated polynucleotide comprises a 5' seed region, a central region and a 3' supplementary region, wherein upon binding to said target gene or long non-coding RNA, the isolated polynucleotide induces a loop to form within the non-coding region of the target gene or long non-coding RNA, and associated methods and uses.

Classes IPC  ?

• C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens

Abrégé

This disclosure describes a novel “kick and kill” strategy as an effective cancer therapy for treating virus-associated cancers. In particular, this disclosure provides a method of reactivating a latent Epstein-Barr virus (EBV) in a cell infected with the EBV. Also provided are a method of eliciting or enhancing an immune response against an EBV-positive cancer cell in a subject infected with the EBV and a method of treating a subject having cancer associated with EBV infection.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 31/136 - Amines, p.ex. amantadine ayant des cycles aromatiques, p.ex. méthadone ayant le groupe amino lié directement au cycle aromatique, p.ex. benzène-amine
• A61K 31/4406 - Pyridines non condensées; Leurs dérivés hydrogénés substituées uniquement en position 3, p.ex. zimeldine
• A61K 31/454 - Pipéridines non condensées, p.ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p.ex. pimozide, dompéridone
• A61K 31/473 - Quinoléines; Isoquinoléines condensées en ortho ou en péri avec des systèmes carbocycliques, p.ex. acridines, phénantridines
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p.ex. rifampine, thiothixène
• A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p.ex. phloridzine liés à un système carbocyclique condensé, p.ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
• A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p.ex. leucoglucosane, hespéridine, érythromycine, nystatine
• C07K 14/725 - Récepteurs de lymphocytes-T
• C07K 16/08 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus

Abrégé

This disclosure teaches multi-classification of endoscopic imaging using a segmentation neural network. The network is trained on imaging data using a novel loss function with components of both focal and boundary loss. During a lithotripsy procedure, images are received by a deployed endoscopic probe. Based on the received imaging data and inference data from its prior learning, the segmentation neural network identifies renal calculi and surgical instruments within the imaging data. The imaging data is modified and displayed to assist the lithotripsy procedure.

Classes IPC  ?

• G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
• A61B 5/20 - Mesure des fonctions urologiques
• G06V 20/69 - Objets microscopiques, p.ex. cellules biologiques ou pièces cellulaires

Abrégé

The present invention relates to attenuated African Swine Fever viruses. The attenuated viruses protect pigs against subsequent challenge with virulent virus. The present invention also relates to the use of such attenuated viruses to treat and/or prevent African Swine Fever. The invention also relates to EP402R proteins of African Swine Fever virus comprising particular amino acid substitutions, as well as polynucleotides encoding such proteins and African Swine Fever viruses comprising such proteins.

Classes IPC  ?

• A61K 39/12 - Antigènes viraux
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 37/04 - Immunostimulants
• C12N 7/00 - Virus, p.ex. bactériophages; Compositions les contenant; Leur préparation ou purification

Abrégé

This disclosure teaches multi-classification of endoscopic imaging using a segmentation neural network. The network is trained on imaging data using a novel loss function with components of both focal and boundary loss. During a lithotripsy procedure, images are received by a deployed endoscopic probe. Based on the received imaging data and inference data from its prior learning, the segmentation neural network identifies renal calculi and surgical instruments within the imaging data. The imaging data is modified and displayed to assist the lithotripsy procedure.

Classes IPC  ?

• G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p.ex. des objets vidéo
• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments
• A61B 1/307 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments pour l'appareil urinaire, p.ex. urétroscopes, cystoscopes
• A61B 18/26 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p.ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p.ex. d'une fibre optique; Pièces à main à cet effet pour produire une onde de choc, p.ex. lithotritie par laser
• G06V 10/14 - Caractéristiques optiques de l’appareil qui effectue l’acquisition ou des dispositifs d’éclairage
• G06V 10/22 - Prétraitement de l’image par la sélection d’une région spécifique contenant ou référençant une forme; Localisation ou traitement de régions spécifiques visant à guider la détection ou la reconnaissance
• G06V 10/26 - Segmentation de formes dans le champ d’image; Découpage ou fusion d’éléments d’image visant à établir la région de motif, p.ex. techniques de regroupement; Détection d’occlusion
• G06V 10/34 - Lissage ou élagage de la forme; Opérations morphologiques; Squelettisation
• G06V 10/774 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p.ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]; Séparation aveugle de source méthodes de Bootstrap, p.ex. "bagging” ou “boosting”
• G06V 10/776 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p.ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]; Séparation aveugle de source Évaluation des performances
• G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux

Abrégé

This disclosure teaches determining a renal calculus size based on calibration data generated from an endoscopic imager. During a lithotripsy procedure, images are received by a deployed endoscopic probe. Based on the received imaging data, the generated calibration data, and known properties of the endoscopic probe, one or more renal calculi in the images are identified and sized. The determined size values are displayed with the images of the renal calculi.

Classes IPC  ?

• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/107 - Mesure de dimensions corporelles, p.ex. la taille du corps entier ou de parties de celui-ci
• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments
• A61B 1/307 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments pour l'appareil urinaire, p.ex. urétroscopes, cystoscopes
• A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures

Abrégé

This disclosure teaches determining a renal calculus size based on calibration data generated from an endoscopic imager. During a lithotripsy procedure, images are received by a deployed endoscopic probe. Based on the received imaging data, the generated calibration data, and known properties of the endoscopic probe, one or more renal calculi in the images are identified and sized. The determined size values are displayed with the images of the renal calculi.

Classes IPC  ?

• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments
• A61B 1/307 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments pour l'appareil urinaire, p.ex. urétroscopes, cystoscopes

Abrégé

The invention relates to protein bacteriocins (PBs) as therapeutic agents, and specifically to protein complexes comprising two or more PB molecules associated with a protein scaffold which comprises cognate immunity protein domains for the effector portions of the respective PBs. In particular, the invention provides an anti-bacterial protein complex comprising (a) a first PB molecule and a second PB molecule; and (b) an immunity protein scaffold comprising a first immunity protein domain and a second immunity protein domain; wherein the first and second immunity protein domains are non-covalently bound to the respective first and second PB molecules.

Classes IPC  ?

• C07K 14/195 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries
• C07K 14/21 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries provenant de Pseudomonadaceae (F)
• C07K 14/24 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries provenant d'Entérobacteriaceae (F), p.ex. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
• C07K 14/245 - Escherichia (G)
• C07K 14/255 - Salmonella (G)
• C07K 14/26 - Klebsiella (G)
• C07K 14/265 - Enterobacter (G)
• C12N 9/22 - Ribonucléases
• C12N 9/96 - Stabilisation d'une enzyme par formation d'un adduct ou d'une composition; Formation de conjugaisons d'enzymes
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• A61K 38/16 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
• A61K 38/46 - Hydrolases (3)
• A61P 31/04 - Agents antibactériens

Abrégé

This disclosure provides methods for converting 5-hydroxymethylcytosine (5hmC) to 5-formylcytosine (5fC) in a nucleic acid and methods for converting 5fC to 5-carboxylcytosine (5caC) in a nucleic acid. The disclosure further provides methods for identifying the locations of 5hmC in a nucleic acid sequence comprising the methods for converting 5hmC to 5fC and/or the methods for converting 5fC to 5caC.

Classes IPC  ?

• C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme
• C12Q 1/6869 - Méthodes de séquençage

Produits et services

Published material in digital format; optical, digital, electronic and magnetic data storage devices bearing electronic publications and materials, data, software, e-books, and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; digital media bearing electronic publications and materials, data, software, e-books and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; computer software for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; electronic databases; electronic publications; publications in electronic form (downloadable), supplied on-line from databases or from facilities provided on the internet; e-books; downloadable electronic publications and materials, data, software, e-books, and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable electronic publications and materials, data, software, e-books, and audio and/or visual content delivered online through a web-browser for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; electronic databases and data sets containing wordlists, lexical and language content and data, legal content and data, academic and research content and data, educational content and data, learning training and instructional content and data, examination and assessment content and data, audio and/or visual content and data, and information relating to teaching, instruction, research and education, law, metadata; information stored in electronic, digital and/or magnetic form for teaching, learning, educational, instructional, training research, professional development, examination, and assessment; publications and materials, data, e-books, and audio and/or visual materials in electronic form, supplied on-line from databases or from facilities provided on the internet; downloadable audio and/or video files containing recorded audio and/or video content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; recorded content in the form of electronic publications and materials, data, e-books and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable software and applications for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable software and applications relating to research, educational, and publishing content and services; software applications delivered to any computing device including desktop, laptop, wearable computer peripheral, tablet computer and/or mobile device for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; software applications delivered to any computing device including desktop, laptop, wearable computer peripheral, tablet computer and/or mobile device relating to research, educational, and publishing content and services; downloadable webcasts; downloadable podcasts; teaching apparatus and/or instruments; instructional apparatus and/or instruments; educational apparatus and/or instruments; downloadable software for publishing or sharing information via global computer and communication networks; communications software for electronically exchanging voice, data, video and/or graphics accessible via computer, mobile, wireless, and telecommunication networks relating to research, educational, and publishing content and services; computer software for accessing and transmitting data and content among consumer electronics devices and/or displays relating to research, educational, or publishing content and services; computer software for transmission and display of digital content, audio works, visual works, audiovisual works, electronic publications, and books,; computer software for browsing and accessing digital content, audio works, visual works, audiovisual works, electronic publications, and books,; computer software for collecting, editing, modifying, organizing, synchronizing, integrating, monitoring, transmitting, storage and sharing of data and/or information relating to research, educational, or publishing content and services; computer software for cloud computing for research, educational, or publishing applications; computer software for running cloud computing based applications relating to research, educational or publishing content and services; computer software used to process, convert, distribute and manipulate digital video, image and/or audio files relating to research, educational, or publishing content and services; computer software development tools for research, development and educational purposes; interfaces for digital content management of wired and wireless electronic devices for accessing, storing, transmitting, and/or sharing of data, information, text, images, audio, video, and/or multimedia content. Publishing services; publishing of electronic publications; electronic publishing services; provision of information relating to teaching, instruction, educational, academic and linguistic research and education; provision of online-electronic publications; publishing services provided by means of the Internet and the world-wide web; publishing by electronic means; publication of electronic books and journals online; providing on-line publications [not downloadable]; distribution of printed or electronic materials relating to education; development and dissemination of teaching materials; provision of digital handbooks, instructional handbooks, and educational materials; provision of educational information in the field of law; services of a data bank, namely the provision of educational information in the field of law; educational services; training services; teaching, educational, academic and linguistic research, instruction and education through the Internet; teaching, educational, academic and linguistic research, instruction and education through a computer database; providing education through video, audio and audio-visual materials; computer assisted teaching services; provision of teaching materials online; online education services in the field of law; providing information concerning education in the field of law; advisory, consultancy and information services for all the above services.

Produits et services

Published material in digital format; optical, digital, electronic and magnetic data storage devices bearing electronic publications and materials, data, software, e-books, and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; digital media bearing electronic publications and materials, data, software, e-books and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; computer software for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; electronic databases; electronic publications; publications in electronic form (downloadable), supplied on-line from databases or from facilities provided on the internet; e-books; downloadable electronic publications and materials, data, software, e-books, and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable electronic publications and materials, data, software, e-books, and audio and/or visual content delivered online through a web-browser for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; electronic databases and data sets containing wordlists, lexical and language content and data, political content and data, academic and research content and data, educational content and data, learning training and instructional content and data, examination and assessment content and data, audio and/or visual content and data, and information relating to teaching, instruction, research and education, politics, metadata; information stored in electronic, digital and/or magnetic form for teaching, learning, educational, instructional, training research, professional development, examination, and assessment; publications and materials, data, e-books, and audio and/or visual materials in electronic form, supplied on-line from databases or from facilities provided on the internet; downloadable audio and/or video files containing recorded audio and/or video content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; recorded content in the form of electronic publications and materials, data, e-books and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable software and applications for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable software and applications relating to research, educational, and publishing content and services; software applications delivered to any computing device including desktop, laptop, wearable computer peripheral, tablet computer and/or mobile device for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; software applications delivered to any computing device including desktop, laptop, wearable computer peripheral, tablet computer and/or mobile device relating to research, educational, and publishing content and services; downloadable webcasts; downloadable podcasts; teaching apparatus and/or instruments; instructional apparatus and/or instruments; educational apparatus and/or instruments; downloadable software for publishing or sharing information via global computer and communication networks; communications software for electronically exchanging voice, data, video and/or graphics accessible via computer, mobile, wireless, and telecommunication networks relating to research, educational, and publishing content and services; computer software for accessing and transmitting data and content among consumer electronics devices and/or displays relating to research, educational, or publishing content and services; computer software for transmission and display of digital content, audio works, visual works, audiovisual works, electronic publications, and books,; computer software for browsing and accessing digital content, audio works, visual works, audiovisual works, electronic publications, and books,; computer software for collecting, editing, modifying, organizing, synchronizing, integrating, monitoring, transmitting, storage and sharing of data and/or information relating to research, educational, or publishing content and services; computer software for cloud computing for research, educational, or publishing applications; computer software for running cloud computing based applications relating to research, educational or publishing content and services; computer software used to process, convert, distribute and manipulate digital video, image and/or audio files relating to research, educational, or publishing content and services; computer software development tools for research, development and educational purposes; interfaces for digital content management of wired and wireless electronic devices for accessing, storing, transmitting, and/or sharing of data, information, text, images, audio, video, and/or multimedia content.

Produits et services

Published material in digital format; optical, digital, electronic and magnetic data storage devices bearing electronic publications and materials, data, software, e-books, and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; digital media bearing electronic publications and materials, data, software, e-books and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; computer software for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; electronic databases; electronic publications; publications in electronic form (downloadable), supplied on-line from databases or from facilities provided on the internet; e-books; downloadable electronic publications and materials, data, software, e-books, and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable electronic publications and materials, data, software, e-books, and audio and/or visual content delivered online through a web-browser for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; electronic databases and data sets containing wordlists, lexical and language content and data, scientific content and data, academic and research content and data, educational content and data, learning training and instructional content and data, examination and assessment content and data, audio and/or visual content and data, and information relating to teaching, instruction, research and education, science, metadata; information stored in electronic, digital and/or magnetic form for teaching, learning, educational, instructional, training research, professional development, examination, and assessment; publications and materials, data, e-books, and audio and/or visual materials in electronic form, supplied on-line from databases or from facilities provided on the internet; downloadable audio and/or video files containing recorded audio and/or video content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; recorded content in the form of electronic publications and materials, data, e-books and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable software and applications for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable software and applications relating to research, educational, and publishing content and services; software applications delivered to any computing device including desktop, laptop, wearable computer peripheral, tablet computer and/or mobile device for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; software applications delivered to any computing device including desktop, laptop, wearable computer peripheral, tablet computer and/or mobile device relating to research, educational, and publishing content and services; downloadable webcasts; downloadable podcasts; teaching apparatus and/or instruments; instructional apparatus and/or instruments; educational apparatus and/or instruments; downloadable software for publishing or sharing information via global computer and communication networks; communications software for electronically exchanging voice, data, video and/or graphics accessible via computer, mobile, wireless, and telecommunication networks relating to research, educational, and publishing content and services; computer software for accessing and transmitting data and content among consumer electronics devices and/or displays relating to research, educational, or publishing content and services; computer software for transmission and display of digital content, audio works, visual works, audiovisual works, electronic publications, and books,; computer software for browsing and accessing digital content, audio works, visual works, audiovisual works, electronic publications, and books,; computer software for collecting, editing, modifying, organizing, synchronizing, integrating, monitoring, transmitting, storage and sharing of data and/or information relating to research, educational, or publishing content and services; computer software for cloud computing for research, educational, or publishing applications; computer software for running cloud computing based applications relating to research, educational or publishing content and services; computer software used to process, convert, distribute and manipulate digital video, image and/or audio files relating to research, educational, or publishing content and services; computer software development tools for research, development and educational purposes; interfaces for digital content management of wired and wireless electronic devices for accessing, storing, transmitting, and/or sharing of data, information, text, images, audio, video, and/or multimedia content. Publishing services; publishing of electronic publications; electronic publishing services; provision of information relating to teaching, instruction, educational, academic and linguistic research and education; provision of online-electronic publications; publishing services provided by means of the Internet and the world-wide web; publishing by electronic means; publication of electronic books and journals online; providing on-line publications [not downloadable]; distribution of printed or electronic materials relating to education; development and dissemination of teaching materials; provision of digital handbooks, instructional handbooks, and educational materials; Provision of educational information in the field of science; Services of a data bank, namely the provision of educational information in the field of science; educational services; training services; teaching, educational, academic and linguistic research, instruction and education through the Internet; teaching, educational, academic and linguistic research, instruction and education through a computer database; providing education through video, audio and audio-visual materials; computer assisted teaching services; provision of teaching materials online; online education services in the field of science; providing information concerning education in the field of science; advisory, consultancy and information services for all the above services.

Produits et services

Published material in digital format; optical, digital, electronic and magnetic data storage devices bearing electronic publications and materials, data, software, e-books, and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; digital media bearing electronic publications and materials, data, software, e-books and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; computer software for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; electronic databases; electronic publications; publications in electronic form (downloadable), supplied on-line from databases or from facilities provided on the internet; e-books; downloadable electronic publications and materials, data, software, e-books, and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable electronic publications and materials, data, software, e-books, and audio and/or visual content delivered online through a web-browser for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; electronic databases and data sets containing wordlists, lexical and language content and data, business content and data, academic and research content and data, educational content and data, learning training and instructional content and data, examination and assessment content and data, audio and/or visual content and data, and information relating to teaching, instruction, research and education, business, metadata; information stored in electronic, digital and/or magnetic form for teaching, learning, educational, instructional, training research, professional development, examination, and assessment; publications and materials, data, e-books, and audio and/or visual materials in electronic form, supplied on-line from databases or from facilities provided on the internet; downloadable audio and/or video files containing recorded audio and/or video content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; recorded content in the form of electronic publications and materials, data, e-books and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable software and applications for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable software and applications relating to research, educational, and publishing content and services; software applications delivered to any computing device including desktop, laptop, wearable computer peripheral, tablet computer and/or mobile device for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; software applications delivered to any computing device including desktop, laptop, wearable computer peripheral, tablet computer and/or mobile device relating to research, educational, and publishing content and services; downloadable webcasts; downloadable podcasts; teaching apparatus and/or instruments; instructional apparatus and/or instruments; educational apparatus and/or instruments; downloadable software for publishing or sharing information via global computer and communication networks; communications software for electronically exchanging voice, data, video and/or graphics accessible via computer, mobile, wireless, and telecommunication networks relating to research, educational, and publishing content and services; computer software for accessing and transmitting data and content among consumer electronics devices and/or displays relating to research, educational, or publishing content and services; computer software for transmission and display of digital content, audio works, visual works, audiovisual works, electronic publications, and books,; computer software for browsing and accessing digital content, audio works, visual works, audiovisual works, electronic publications, and books,; computer software for collecting, editing, modifying, organizing, synchronizing, integrating, monitoring, transmitting, storage and sharing of data and/or information relating to research, educational, or publishing content and services; computer software for cloud computing for research, educational, or publishing applications; computer software for running cloud computing based applications relating to research, educational or publishing content and services; computer software used to process, convert, distribute and manipulate digital video, image and/or audio files relating to research, educational, or publishing content and services; computer software development tools for research, development and educational purposes; interfaces for digital content management of wired and wireless electronic devices for accessing, storing, transmitting, and/or sharing of data, information, text, images, audio, video, and/or multimedia content. Publishing services; publishing of electronic publications; electronic publishing services; provision of information relating to teaching, instruction, educational, academic and linguistic research and education; provision of online-electronic publications; publishing services provided by means of the Internet and the world-wide web; publishing by electronic means; publication of electronic books and journals online; providing on-line publications [not downloadable]; distribution of printed or electronic materials relating to education; development and dissemination of teaching materials; provision of digital handbooks, instructional handbooks, and educational materials; provision of educational information in the field of business; services of a data bank, namely the provision of educational information in the field of business; educational services; training services; teaching, educational, academic and linguistic research, instruction and education through the Internet; teaching, educational, academic and linguistic research, instruction and education through a computer database; providing education through video, audio and audio-visual materials; computer assisted teaching services; provision of teaching materials online; online education services in the field of business; providing information concerning education in the field of business; advisory, consultancy and information services for all the above services.

Abrégé

This disclosure provides a novel method and system for characterizing morphodynamic profiles of objects, such as biological entities. This disclosure provides a shape, appearance, and motion (SAM) phenotype Observation Tool (SPOT). SPOT establishes a standardized SAM "phenome," image descriptors resembling single-cell transcriptomes, to comprehensively quantify a cell's instantaneous state without prior knowledge. SPOT also establishes a standardized workflow for temporal analysis. SPOT is a generalist tool, applicable to any live-cell imaging and advances biomedical discovery through its standardized, unbiased, streamlined workflow to quantify phenotypic heterogeneity and predict phenotype-genotype-function coupling.

Classes IPC  ?

• G06V 20/69 - Objets microscopiques, p.ex. cellules biologiques ou pièces cellulaires
• G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p.ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersections; Analyse de connectivité, p.ex. de composantes connectées
• G06T 7/00 - Analyse d'image
• G16H 50/00 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies

Abrégé

The present disclosure relates to methods of treating cancer in subjects by a two-part treatment regime comprising a first treatment that provides antigen-specific CD4+ and/or CD8+ T cells in the subject and a second treatment, administered after a time interval, that induces systemic and/or tumor-specific inflammation in the subject.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/12 - Antigènes viraux
• C07K 16/00 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux

Abrégé

The invention relates to methods for treating prostate cancer by targeting the generation of splice variants of the androgen receptor. In one aspect, this can be achieved by targeting JMJD6 to reduce the production of androgen receptor splice variants. The invention finds particular use in the treatment of prostate cancer that is resistant to conventional androgen therapy.

Classes IPC  ?

• A61K 31/44 - Pyridines non condensées; Leurs dérivés hydrogénés
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention is directed to methods for confirming that a multiple sclerosis (MS) patient is suffering from a relapse. In particular, methods comprising: comparing a concentration of one or more metabolite(s) present in a sample obtained from the patient with the concentration of the same one or more metabolite(s) in a reference standard, wherein the one or more metabolite(s) are selected from: leucine, lysine, asparagine, phenylalanine, glucose, β-hydroxybutyrate, myo-inositol, a lipoprotein having a —CH3 group of an HDL and/or LDL, a lipoprotein having a —CH3 group of a VLDL, a lipoprotein having a —(CH2)n group of an HDL and/or LDL, a lipoprotein having a βCH2 group, and an N-acetylated glycoprotein; and confirming or not that the patient is suffering from a relapse.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/92 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des lipides, p.ex. le cholestérol

Abrégé

i,ki+1,ki,k+1n,m11) of between 0.2 μm and 6 μm from the first face.

Classes IPC  ?

• H01L 29/16 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée
• C30B 31/20 - Dopage par irradiation au moyen de radiations électromagnétiques ou par rayonnement corpusculaire
• G01R 33/12 - Mesure de propriétés magnétiques des articles ou échantillons de solides ou de fluides
• G06N 10/00 - Informatique quantique, c. à d. traitement de l’information fondé sur des phénomènes de mécanique quantique
• H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
• H01L 29/24 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des matériaux semi-conducteurs inorganiques non couverts par les groupes , ,  ou
• H01L 29/32 - Corps semi-conducteurs ayant des surfaces polies ou rugueuses les défectuosités étant à l'intérieur du corps semi-conducteur
• H01L 29/66 - Types de dispositifs semi-conducteurs
• B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p.ex. calcul quantique ou logique à un électron

Abrégé

The present invention relates to the detection of disease states such as clonal haematopoiesis and cancer as well as fetal screening by analysing thrombocytes for disease associated markers. The methods comprises steps of providing a biological sample comprising thrombocytes; extracting nucleic acid from said biological sample; analysing said nucleic acid to identify the presence of one or more clonal haematopoiesis associated mutations or cancer associated nucleic acid fragments; and indicating the presence or prognosis of clonal haematopoiesis or cancer based on the presence of one or more clonal haematopoiesis associated mutations or cancer associated nucleic acid fragments; or or analysing the nucleic acids for genetic information related to the foetus.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

Provided herein are modified forms of Semaphorin 3A (Sema3A) polypeptide having one or more amino acid substitutions and/or deletions compared to a wild type Sema3A protein. Further provided are nucleic acid molecules encoding the modified Sema3A polypeptide, compositions including the same and uses thereof in treating various immune-related conditions.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p.ex. agents antirhumatismaux; Médicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
• C12N 15/86 - Vecteurs viraux

Abrégé

1233 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment cancer.

Classes IPC  ?

• A61K 51/04 - Composés organiques
• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
• A61P 35/00 - Agents anticancéreux
• A61K 101/02 - Halogènes

Abrégé

A pharmaceutical composition comprising a nucleic acid molecule encoding a variable domain deleted E2 polypeptide of HCV (e.g., E2Delta123). The composition is suitable for use, for use, or when used, in the treatment or prevention of HCV infection. The nucleic acid molecule may be DNA or RNA or a modified or synthetic form, or contained within a plasmid, a viral or non-viral vector for vaccination, a polynucleotide expression cassette, or a cell for vector propagation. Methods of administration as prime and boost vaccinations are also provided.

Classes IPC  ?

• A61K 39/29 - Virus de l'hépatite
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

The present invention relates to attenuated African Swine Fever viruses. The attenuated viruses protect pigs against subsequent challenge with virulent virus. The present invention also relates to the use of such attenuated viruses to treat and/or prevent African Swine Fever.

Classes IPC  ?

• A61K 39/12 - Antigènes viraux

Abrégé

The present invention provides affinity matured recombinant monoclonal antibodies (mAbs) and fragments that bind specifically to an HLA-E- peptide complex, including HLA-E-VL9 complexes, and. regulate the cytotoxicity effector cell function of NK and/or CD8+ T-cells positive for cell-surface expression of NKG2A ("NKG2A+"). Herein, monoclonal antibodies were recombinant.lv derived from isolated functional HLA-E- VL9-specific mAbs from HLA-E- VL9 peptide- immunized HLA-B transgenic mice and from the naive human B cell repertoire. Such antibodies are capable of regulating effector cell cytotoxicity' and can preferentially recognize HLA-E- VL9 peptide complexes expressed on the surface of tumor cells. The monoclonal antibodies were subject to one or more rounds of affinity7 maturation. The invention provides methods for using affinity matured HLA-E- VL9 mAbs to modulate NK and/or CD8+T- cell function as part of immunotherapeutic strategies.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus

Abrégé

The present invention provides affinity matured recombinant monoclonal antibodies (mAbs) and fragments that bind specifically to an HLA-E- peptide complex, including HLA-E-VL9 complexes, and. regulate the cytotoxicity effector cell function of NK and/or CD8+ T-cells positive for cell-surface expression of NKG2A ("NKG2A+"). Herein, monoclonal antibodies were recombinant.lv derived from isolated functional HLA-E- VL9-specific mAbs from HLA-E- VL9 peptide- immunized HLA-B transgenic mice and from the naive human B cell repertoire. Such antibodies are capable of regulating effector cell cytotoxicity' and can preferentially recognize HLA-E- VL9 peptide complexes expressed on the surface of tumor cells. The monoclonal antibodies were subject to one or more rounds of affinity7 maturation. The invention provides methods for using affinity matured HLA-E- VL9 mAbs to modulate NK and/or CD8+T- cell function as part of immunotherapeutic strategies.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire

Abrégé

The present disclosure provides compositions and methods related to TET-assisted Pyridine Borane Sequencing (TAPS). In particular, the present disclosure provides optimized TAPS for cfDNA (cfTAPS), which provides high-quality and high-depth whole-genome cell-free methylomes. The compositions and methods provided herein facilitate the acquisition of multimodal information about cfDNA characteristics, including DNA methylation, tissue of origin, and DNA fragmentation for the diagnosis and treatment of disease.

Classes IPC  ?

• C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme

Abrégé

The present disclosure provides compositions and methods related to TET-assisted Pyridine Borane Sequencing (TAPS). In particular, the present disclosure provides optimized TAPS for cfDNA (cfTAPS), which provides high-quality and high-depth whole-genome cell-free methylomes. The compositions and methods provided herein facilitate the acquisition of multimodal information about cfDNA characteristics, including DNA methylation, tissue of origin, and DNA fragmentation for the diagnosis and treatment of disease.

Classes IPC  ?

• C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme

Abrégé

Described herein are processes and compositions for ultrasound-triggered liposome payload release, including a process for gelation and a process for enzyme catalysis.

Classes IPC  ?

• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 49/22 - Préparations pour échographie; Préparations pour imagerie par ultrasons
• A61K 47/42 - Protéines; Polypeptides; Leurs produits de dégradation; Leurs dérivés p.ex. albumine, gélatine ou zéine
• A61K 47/02 - Composés inorganiques
• A61K 47/10 - Alcools; Phénols; Leurs sels, p.ex. glycérol; Polyéthylène glycols [PEG]; Poloxamères; Alkyléthers de PEG/POE
• A61K 47/36 - Polysaccharides; Leurs dérivés, p.ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
• A61K 47/18 - Amines; Amides; Urées; Composés d’ammonium quaternaire; Acides aminés; Oligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/24 - Composés organiques, p.ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p.ex. cyclométhicone ou phospholipides
• A61K 9/127 - Liposomes
• C12N 9/10 - Transférases (2.)

Abrégé

The invention relates to methods for treating prostate cancer by targeting the generation of splice variants of the androgen receptor. In one aspect, this can be achieved by targeting JMJD6 to reduce the production of androgen receptor splice variants. The invention finds particular use in the treatment of prostate cancer that is resistant to conventional androgen therapy.

Classes IPC  ?

• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques 
• A61K 31/194 - Acides carboxyliques, p.ex. acide valproïque ayant plusieurs groupes carboxyle, p.ex. acides succinique, maléique ou phtalique
• A61K 31/44 - Pyridines non condensées; Leurs dérivés hydrogénés
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to methods for treating prostate cancer by targeting the generation of splice variants of the androgen receptor. In one aspect, this can be achieved by targeting JMJD6 to reduce the production of androgen receptor splice variants. The invention finds particular use in the treatment of prostate cancer that is resistant to conventional androgen therapy.

Classes IPC  ?

• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques 
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61K 31/194 - Acides carboxyliques, p.ex. acide valproïque ayant plusieurs groupes carboxyle, p.ex. acides succinique, maléique ou phtalique
• A61K 31/44 - Pyridines non condensées; Leurs dérivés hydrogénés
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• A61P 35/00 - Agents anticancéreux
• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique

Abrégé

The invention relates to a method for purifying an adenovirus comprising (a) providing a liquid sample comprising adenovirus, (b) clarifying said sample by depth filtration, (c) performing anion exchange chromatography comprising the steps of (i) directly applying the clarified sample of (b) to an anion exchange column, (ii) eluting adenovirus from the anion exchange column to provide an eluate. The invention also relates to adenovirus produced from said methods, and to compositions comprising same.

Classes IPC  ?

• C12N 7/00 - Virus, p.ex. bactériophages; Compositions les contenant; Leur préparation ou purification

Abrégé

The invention relates to a method for preparing an adenovirus comprising a) providing a host cell in a medium capable of supporting growth of said host cell b) contacting said host cell with an adenovirus c) incubating to allow infection of said cell by said adenovirus d) incubating to allow production of adenovirus by said host cell wherein said host cell is, or is derived from, a HEK293 cell, and wherein the medium comprises BalanCD HEK293. The invention also relates to adenovirus produced, and to compositions comprising said adenovirus.

Classes IPC  ?

• C12N 7/00 - Virus, p.ex. bactériophages; Compositions les contenant; Leur préparation ou purification
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
• C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains

Abrégé

Neisseria meningitidisNeisseria meningitidis, characterised in that said viral vector is an adenovirus based vector. The invention also relates to uses, methods and kits.

Classes IPC  ?

• A61K 39/015 - Antigènes d'Hemosporidia, p.ex. antigènes de Plasmodium
• A61K 39/095 - Neisseria
• A61K 39/02 - Antigènes bactériens
• A61K 39/12 - Antigènes viraux
• A61P 31/04 - Agents antibactériens
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

This disclosure describes a novel "kick and kill" strategy as an effective cancer therapy for treating virus-associated cancers. In particular, this disclosure provides a method of reactivating a latent Epstein-Barr virus (EBV) in a cell infected with the EBV. Also provided are a method of eliciting or enhancing an immune response against an EBV-positive cancer cell in a subject infected with the EBV and a method of treating a subject having cancer associated with EBV infection.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• C12N 7/00 - Virus, p.ex. bactériophages; Compositions les contenant; Leur préparation ou purification
• C12N 15/09 - Technologie d'ADN recombinant

Abrégé

Provided herein are complex, cellularized structures comprising extracellular matrix proteins (EMP), methods of making said structures and method of using said structures for disease modelling and tissue implantation. In some embodiments, the complex, cellularized structures comprise collagen.

Classes IPC  ?

• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 1/26 - Inoculateur ou échantillonneur
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet

Abrégé

Recombinant monoclonal antibodies (mAbs) and fragments that bind specifically to an HLA-E-peptide complex, including HLA-E-VL9 complexes, and regulate the cytotoxicity effector cell function of NK and/or CD8+ T-cells positive for cell-surface expression of NKG2A ("NKG2A+"). Herein, monoclonal antibodies were recombinantly derived from isolated functional HLA-E-VL9-specific mAbs from HLA-E-VL9 peptide-immunized HLA-B transgenic mice and from the naive human B cell repertoire. Such antibodies are capable of regulating effector cell cytotoxicity and can preferentially recognize HLA-E-VL9 peptide complexes expressed on the surface of tumor cells. The invention provides methods for using HLA-E-VL9 m Abs to modulate NK and/or CD8+T-cell function as part of immunotherapeutic strategies.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire

Abrégé

The present invention relates to improved single domain antibodies that target SARS-CoV-2, multivalent polypeptides and fusion proteins comprising the single domain antibodies. The present invention also provides coronavirus binding molecules that bind two different epitopes on the receptor binding domain of a spike protein of a coronavirus. The coronavirus binding molecules are based on joining two antigen binding molecules together via a linker. The present invention provides the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in treating and/or preventing coronavirus, as well as the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in the detection and diagnosis of coronavirus using various methods, assays and kits.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
• G01N 33/577 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet faisant intervenir des anticorps monoclonaux

Abrégé

Among other things, the present disclosure provides compositions and methods for analysis of cytosine modifications in nucleic acid sequences. In some embodiments, the present disclosure provides subtraction-free methods for detection of cytosine modifications in one or more nucleic acid sequences.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]

Produits et services

Computer hardware, namely portable electronic devices bearing electronic publications and materials, data, software, e-books, and audio and/or visual content, for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; published material in digital format; optical, digital, electronic and magnetic data storage devices bearing electronic publications and materials, data, software, e-books, and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; digital media bearing electronic publications and materials, data, software, e-books and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; computer software for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; electronic publications; e-books; downloadable electronic publications and materials, data, software, e-books, and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable electronic publications and materials, data, software, e-books, and audio and/or visual content delivered online through a web-browser for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; electronic databases and data sets containing wordlists, lexical and language content and data, dictionary and thesauri content and data, encyclopaedic content and data, academic and research content and data, educational content and data, learning training and instructional content and data, examination and assessment content and data, audio and/or visual content and data, information relating to teaching, instruction, research and education, metadata; information stored in electronic, digital and/or magnetic form for teaching, learning, educational, instructional, training research, professional development, examination, and assessment; publications and materials, data, e-books, and audio and/or visual materials in electronic form, supplied on-line from databases or from facilities provided on the internet; dvds, cds, hard disks, portable usb flash memory devices, and other digital recording media bearing electronic publications and materials, data, software, e-books, and audio and/or visual materials for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable audio and/or video files containing recorded audio and/or video content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; recorded content in the form of electronic publications and materials, data, e-books and audio and/or visual content for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable software and applications for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; downloadable software and applications relating to research, educational, and publishing content and services; software applications delivered online through a web-browser for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; software applications delivered online through a web-browser relating to research, educational, and publishing content and services; software applications delivered to any computing device including desktop, laptop, wearable computer peripheral, tablet computer and/or mobile device for teaching, learning, educational, instructional, training, research, professional development, examination, and assessment purposes; software applications delivered to any computing device including desktop, laptop, wearable computer peripheral, tablet computer and/or mobile device relating to research, educational, and publishing content and services; downloadable webcasts; downloadable podcasts; teaching apparatus and/or instruments; instructional apparatus and/or instruments; educational apparatus and/or instruments; downloadable software for publishing or sharing information via global computer and communication networks; communications software for electronically exchanging voice, data, video and/or graphics accessible via computer, mobile, wireless, and telecommunication networks relating to research, educational, and publishing content and services; computer software for processing images, graphics, audio, video, and/or text; electronic devices for providing access to the internet or viewing information on global computer networks relating to research, educational, and publishing content and services; computer software for accessing and transmitting data and content among consumer electronics devices and/or displays relating to research, educational, or publishing content and services; computer software for transmission and display of digital content, audio works, visual works, audiovisual works, electronic publications, books, movies, and music; computer software for browsing and accessing digital content, audio works, visual works, audiovisual works, electronic publications, books, movies and/or music; computer software for collecting, editing, modifying, organizing, synchronizing, integrating, monitoring, transmitting, storage and sharing of data and/or information relating to research, educational, or publishing content and services; computer software for cloud computing for research, educational, or publishing applications; computer software for use in cloud infrastructure management for research, educational or publishing applications; computer software for running cloud computing based applications relating to research, educational or publishing content and services; computer software used to process, convert, distribute and manipulate digital video, image and/or audio files relating to research, educational, or publishing content and services; computer software development tools for research, development and educational purposes; interfaces for digital content management of wired and wireless electronic devices for accessing, storing, transmitting, and/or sharing of data, information, text, images, audio, video, and/or multimedia content; speech processing equipment for use in education; speech recognition equipment for use in education; parts and fittings for all the above goods. Printed music; dictionaries; bibles; periodical publications; newspapers; magazines; books; text books; instructional and teaching material; degree certificates; educational or training award certificates; diplomas; course notes; study guides; pamphlets; journals; newsletters; prospectuses; catalogues; handbooks; photographs and photographic material; pictures; stationery; note books; note pads; forms; calendars; writing instruments; pens; pencils; pencil cases; pencil sharpeners; erasers; rulers; writing materials; book marks; pennants; badges made of paper and cardboard; maps; address books; prints; posters; wall charts; diaries; postcards; labels; adhesive stickers; tickets; parts and fittings for all the above goods. Publishing services; publishing of electronic publications; electronic publishing services; provision of information relating to teaching, instruction, educational, academic and linguistic research and education; provision of online-electronic publications; publishing services provided by means of the Internet and the world-wide web; distribution of printed or electronic materials relating to education; development and dissemination of teaching materials; provision of digital handbooks, instructional handbooks, and educational materials; provision of an electronic or on-line dictionary; provision of an electronic or on-line thesaurus; editing and/or publishing of a dictionary through the Internet; provision of information in the field of general encylopaedic knowledge; services of a data bank, namely the provision of encyclopaedic data; educational services; training services; teaching, educational, academic and linguistic research, instruction and education through the Internet; teaching, educational, academic and linguistic research, instruction and education through a computer database; conducting correspondence courses; teaching, lecturing and/or tutorial services; providing education through video, audio and audio-visual materials; providing feedback for teachers on pupils progress; training of teachers; computer assisted teaching services; provision of teaching materials online; provision of distance learning for the level of primary education, secondary education, undergraduate university education and/or post-graduate university education; provision of correspondence courses; distance learning courses; e-learning training or education courses; online education services in the field of the assessment and improvement of student learning, teacher training and/or curriculum development; examination services; educational examinations; educational assessment services; awarding of educational qualifications; providing information concerning education; academic services provided by universities; university services; advisory, consultancy and information services for all the above services.

Abrégé

Provided herein are modified forms of Semaphorin 3A (Sema3A) polypeptide having one or more amino acid substitutions and/or deletions compared to a wild type Sema3A protein. Further provided are nucleic acid molecules encoding the modified Sema3A polypeptide, compositions including the same and uses thereof in treating various immune-related conditions.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p.ex. agents antirhumatismaux; Médicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

Provided herein are modified forms of Semaphorin 3A (Sema3A) polypeptide having one or more amino acid substitutions and/or deletions compared to a wild type Sema3A protein. Further provided are nucleic acid molecules encoding the modified Sema3A polypeptide, compositions including the same and uses thereof in treating various immune-related conditions.

Classes IPC  ?

• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p.ex. agents antirhumatismaux; Médicaments anti-inflammatoires non stéroïdiens [AINS]
• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

A pharmaceutical composition comprising a nucleic acid molecule encoding a variable domain deleted E2 polypeptide of HCV (e.g., E2Delta123). The composition is suitable for use, for use, or when used, in the treatment or prevention of HCV infection. The nucleic acid molecule may be DNA or RNA or a modified or synthetic form, or contained within a plasmid, a viral or non-viral vector for vaccination, a polynucleotide expression cassette, or a cell for vector propagation. Methods of administration as prime and boost vaccinations are also provided.

Classes IPC  ?

• A61K 39/29 - Virus de l'hépatite
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61P 37/04 - Immunostimulants

Abrégé

A pharmaceutical composition comprising a nucleic acid molecule encoding a variable domain deleted E2 polypeptide of HCV (e.g., E2Delta123). The composition is suitable for use, for use, or when used, in the treatment or prevention of HCV infection. The nucleic acid molecule may be DNA or RNA or a modified or synthetic form, or contained within a plasmid, a viral or non-viral vector for vaccination, a polynucleotide expression cassette, or a cell for vector propagation. Methods of administration as prime and boost vaccinations are also provided.

Classes IPC  ?

• A61K 39/29 - Virus de l'hépatite
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C12N 15/51 - Virus de l'hépatite

Abrégé

A method for localizing epigenetic modifications of DNA is provided, including: providing a target DNA strand having a least one epigenetic modification, wherein the target DNA strand is annealed to a non-target DNA stand, wherein each of the target DNA strand and the non-target DNA strand is labeled with a first fluorophore; labeling the at least one epigenetic modification with a second fluorophore; annealing a first probe to the target DNA strand and annealing a second probe to the non-target DNA strand; immobilizing the target DNA strand on a support; and detecting the first and second fluorophores immobilized on the support. Also provided is a method of diagnosing a disease or condition, such as cancer, in a subject suspected of having the disease by localizing epigenetic modifications of DNA from a patient sample and comparing to a reference epigenetic profile associated with the disease or condition.

Classes IPC  ?

• C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

The present invention relates to attenuated African Swine Fever viruses. The attenuated viruses protect pigs against subsequent challenge with virulent virus. The present invention also relates to the use of such attenuated viruses to treat and/or prevent African Swine Fever.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/12 - Antigènes viraux
• A61P 31/20 - Antiviraux pour le traitement des virus ADN

Abrégé

The present invention relates to attenuated African Swine Fever viruses. The attenuated viruses protect pigs against subsequent challenge with virulent virus. The present invention also relates to the use of such attenuated viruses to treat and/or prevent African Swine Fever. The invention also relates to EP402R proteins of African Swine Fever virus comprising particular amino acid substitutions, as well as polynucleotides encoding such proteins and African Swine Fever viruses comprising such proteins.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/12 - Antigènes viraux
• A61P 31/20 - Antiviraux pour le traitement des virus ADN

Abrégé

The present disclosure provides a bisulfite-free, long-read, base-resolution method named long-read TAPS (lrTAPS) for detecting 5-Methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in a nucleic acid sequence. lrTAPS comprises mild enzymatic and chemical reactions to detect 5mC and 5hmC, the two major epigenetic marks found in the mammalian genome, quantitatively at base-resolution without affecting unmodified cytosine.

Classes IPC  ?

• C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme

Abrégé

Described herein are processes and compositions for ultrasound-triggered liposome payload release, including a process for gelation and a process for enzyme catalysis.

Classes IPC  ?

• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 9/127 - Liposomes
• A61K 38/43 - Enzymes; Proenzymes; Leurs dérivés
• C12N 9/00 - Enzymes, p.ex. ligases (6.); Proenzymes; Compositions les contenant; Procédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 9/10 - Transférases (2.)
• A61L 31/04 - Matériaux macromoléculaires

Abrégé

Described herein are processes and compositions for ultrasound-triggered liposome payload release, including a process for gelation and a process for enzyme catalysis.

Classes IPC  ?

• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 9/10 - Dispersions; Emulsions
• A61K 9/127 - Liposomes
• C12N 9/00 - Enzymes, p.ex. ligases (6.); Proenzymes; Compositions les contenant; Procédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 9/10 - Transférases (2.)

Abrégé

Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.

Classes IPC  ?

• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p.ex. par les adjuvants chimiques
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c. à d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61K 47/65 - Séquences de liaison, liants ou bras-espaceurs peptidiques, p.ex. séquences de liaison peptidiques vulnérable aux protéases
• A61K 47/59 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. polyurées ou polyuréthanes
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique

Abrégé

This disclosure provides methods for cost-effective bisulfite-free identification in DNA, including whole genomic DNA, of the locations of one or more of 5-methylcytosine, 5-hydroxymethylcytosine, 5-carboxylcytosine and 5-formylcytosine. The methods described herein are based on the conversion of modified cytosine (5mC, 5hmC, 5fC, 5caC) to dihydrouracil (DHU), for example by TET-assisted pyridine borane treatment, followed by endonuclease cleavage of the DHU, and identification of the cleavage site, which corresponds to the location of the modified cytosine.

Classes IPC  ?

• C12Q 1/6869 - Méthodes de séquençage
• C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme

Abrégé

A method for localizing epigenetic modifications of DNA is provided, including: providing a target DNA strand having a least one epigenetic modification, wherein the target DNA strand is annealed to a non-target DNA strand, wherein each of the target DNA strand and the non-target DNA strand is labeled with a first fluorophore; labeling the at least one epigenetic modification with a second fluorophore; annealing a first probe to the target DNA strand and annealing a second probe to the non-target DNA strand; immobilizing the target DNA strand on a support; and detecting the first and second fluorophores immobilized on the support. Also provided is a method of diagnosing a disease or condition, such as cancer, in a subject suspected of having the disease by localizing epigenetic modifications of DNA from a patient sample and comparing to a reference epigenetic profile associated with the disease or condition.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en général; Appareils appropriés
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur
• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet

Abrégé

The present disclosure relates to genetically encoded low affinity, fluorescent Ca2+ indicators, which may be targeted to endoplasmic reticulum, the sarcoplasmic reticulum and/or the mitochondria. It also relates to polynucleotides, vectors and host cells which encode or include such low affinity Ca2+ indicators, and methods of detecting Ca2+ levels in a cell using such indicators.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p.ex. cellules transformées par des virus
• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des micro-organismes viables
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur

Abrégé

The present disclosure relates to genetically encoded low affinity, fluorescent Ca2+ indicators, which may be targeted to endoplasmic reticulum, the sarcoplasmic reticulum and/or the mitochondria. It also relates to polynucleotides, vectors and host cells which encode or include such low affinity Ca2+ indicators, and methods of detecting Ca2+ levels in a cell using such indicators.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p.ex. cellules transformées par des virus
• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des micro-organismes viables
• C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur

Produits et services

Education services; training services; educational examination services; design and provision of educational and training programmes, courses and examinations; educational assessment services to determine standards of education; educational assessment of training and awards; planning, arranging and conducting educational events; provision of training; conducting correspondence courses; providing training events; teaching, educational research, instruction and education by means of a computer database; providing online grammar and vocabulary materials; providing online video and audio materials for education; providing feedback for teachers on pupils progress; training of teachers; computer assisted teaching services; online education for the assessment and improvement of student learning or teacher training; provision of distance learning for child literacy; publishing services; publishing of electronic publications; electronic publishing services; provision of online-electronic publications; publishing services provided by means of the Internet and world-wide web; provision of teaching materials online; dissemination of printed or electronic materials relating to education; development and dissemination of teaching material; provision of online digital handbooks, instructional handbooks, and educational materials in the field of education; online digital publishing services; dissemination of educational materials via global computer information network namely, digital textbooks, reading materials, instructional materials and study tools for students; organization of competitions, awards, quizzes, games and recreational activities; organizing and arranging of cultural and entertainment events; production, presentation, provision and distribution of blogs, webinars, podcasts and vodcasts; consultancy, advisory and information services relating to the aforesaid services.

Abrégé

A method for characterising motion of one or more objects in a time ordered image dataset comprising a plurality of time ordered data frames, the method comprising: selecting a reference data frame from the plurality of time ordered data frames (210); extracting a plurality of image patches from at least a part of the reference data frame (220); identifying a location of each image patch of at least a subset of the plurality of image patches in each data frame (230); defining, based on the identified locations, a mesh for each data frame, wherein vertices of each mesh correspond to respective identified locations of image patches in the corresponding data frame (240); and deriving, from the meshes, a motion signature for the time ordered image dataset, the motion signature characteristic of the motion of the one or more objects in the plurality of time ordered data frames (250).

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06T 7/223 - Analyse du mouvement utilisant la correspondance de blocs
• G06T 7/246 - Analyse du mouvement utilisant des procédés basés sur les caractéristiques, p.ex. le suivi des coins ou des segments

Abrégé

Provided is a method for evaluating the monetary value of a patent. The method comprises: acquiring a patent factor of an object patent; acquiring commercial data of a company holding the patent; acquiring technology market information in an application country of technology involved in the patent, the technology market information at least comprising technology breadth information about the patent; and based on the patent factor, the commercial data and the technology market information, using a pre-set calculation model to estimate the monetary value of the patent. The calculation model comprises a calculation function and variant coefficients corresponding to the patent factor, the commercial data and the technology market information, and variants input for the calculation function comprise: the product of the patent factor and the corresponding variant coefficient, the product of the commercial factor and the corresponding variant coefficient, and the product of the technology market information and the corresponding variant coefficient.

Classes IPC  ?

• G06Q 50/18 - Services juridiques; Maniement de documents juridiques

Abrégé

A method of localizing portable apparatus (100) in an environment, the method comprising obtaining captured image data representing an image captured by an imaging device (106) associated with the portable apparatus, and obtaining mesh data representing a 3-dimensional textured mesh of at least part of the environment. The mesh data is processed to generate a plurality of synthetic images, each synthetic image being associated with a pose within the environment and being a simulation of an image that would be captured by the imaging device from that associated pose. The plurality of synthetic images is analyzed to find a said synthetic image similar to the captured image data, and an indication is provided of a pose of the portable apparatus within the environment based on the associated pose of the similar synthetic image.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
• G01C 21/32 - Structuration ou formatage de données cartographiques
• G06T 5/40 - Amélioration ou restauration d'image en utilisant des techniques d'histogrammes
• G06T 17/05 - Modèles géographiques

Abrégé

Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.

Classes IPC  ?

• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p.ex. par les adjuvants chimiques
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c. à d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• A61K 47/59 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. polyurées ou polyuréthanes
• A61K 47/65 - Séquences de liaison, liants ou bras-espaceurs peptidiques, p.ex. séquences de liaison peptidiques vulnérable aux protéases
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

A method of localizing portable apparatus (200) obtains: a stored experience data set comprising a set of connected nodes; captured location representation data provided by at least one sensor associated with the portable apparatus, and a current pose estimate of the portable apparatus within the environment. The pose estimate is used to select a candidate set of the nodes that contain a potential match for the captured location representation data. The pose estimate is used to obtain a set of paths from path memory data, each said path comprising a set of said nodes previously traversed in the environment under similar environmental/visual conditions. The set of paths is used to refine the candidate set. The captured location representation data and the refined candidate set of nodes is compared in order to identify a current pose of the portable apparatus within the environment.

Classes IPC  ?

• G01C 21/34 - Recherche d'itinéraire; Guidage en matière d'itinéraire
• G01S 5/16 - Localisation par coordination de plusieurs déterminations de direction ou de ligne de position; Localisation par coordination de plusieurs déterminations de distance utilisant des ondes électromagnétiques autres que les ondes radio
• G01C 21/28 - Navigation; Instruments de navigation non prévus dans les groupes spécialement adaptés pour la navigation dans un réseau routier avec corrélation de données de plusieurs instruments de navigation
• G05D 1/02 - Commande de la position ou du cap par référence à un système à deux dimensions
• G01C 21/36 - Dispositions d'entrée/sortie pour des calculateurs embarqués
• G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
• G01C 21/30 - Mise en coïncidence avec des cartes ou des contours
• H04N 7/18 - Systèmes de télévision en circuit fermé [CCTV], c. à d. systèmes dans lesquels le signal vidéo n'est pas diffusé

Produits et services

Providing on-line publications (not downloadable); publishing; electronic publishing; teaching, instructional and educational services; educational testing services; educational assessment services; examination services; provision of assessment and examinations leading to qualification; instruction and education by means of the Internet; providing information regarding the teaching of English language; instruction and education by means of a computer database; providing access to grammar and vocabulary materials online; providing access to video and audio materials for education; providing feedback for teachers on pupils progress; training of teachers; computer assisted teaching services; provision of teaching materials online; provision of distance learning; online education services in the field of the assessment and improvement of student learning, teacher training and/or curriculum development; provision of digital handbooks, instructional handbooks, and educational materials in the field of education; online testing of English language teaching; provision of an electronic or on-line dictionary and thesaurus (non-downloadable); information and advisory services all relating to the aforesaid.

Produits et services

Published material in digital format; optical, electronic and magnetic data storage media bearing recorded information; downloadable sounds, downloadable images, downloadable text; downloadable sounds, downloadable images, downloadable text and information provided by telecommunications networks, by online delivery and by way of the Internet and the world wide web; computer software; downloadable electronic publications; downloadable software applications for use on portable electronic devices; information stored in electronic, digital and magnetic form; downloadable publications in electronic form, supplied on-line from databases or from facilities provided on the Internet; downloadable educational course materials; instructional and teaching apparatus and instruments; educational apparatus and instruments; downloadable software applications. Paper, cardboard; printed matter; periodical publications; newspapers; magazines; books; instructional and teaching material; degree certificates; educational or training award certificates; diplomas; course notes; study guides; pamphlets; journals; newsletters; prospectuses; catalogues; handbooks; photographs and photographic material; pictures; stationery; note books; note pads; forms; calendars; writing instruments; pens; pencils; pencil cases; pencil sharpeners; erasers; rulers; writing materials; book marks; pennants; badges made of paper and cardboard; maps; paper weights; address books; prints; posters; wall charts; diaries; greeting cards; postcards; gift bags; gift wrap; envelopes; labels; adhesive stickers; tickets. Business advice and analysis; business research services; business networking services; business consultancy services; business management services; business process management and consulting; business services related to science, technology and innovation; business strategy services; facilitation and brokering services in connection with the exchange and promotion of knowledge between companies, academia and organisations; provision of business information and support services; business services relating to the arrangement of joint ventures and venture capital schemes; business services to facilitate and support the transfer of technology; business advisory services for the purpose of commercialising technology; business advisory services to support the development and promotion of spin-out projects and companies; provision of business incubator services, namely rental of office equipment, office support services and business support services; management consulting; coordination and management of centres of excellence; coordination and management of research facilities; market research and analysis services; data processing; data compilation and retrieval; compilation of statistical data relating to medical research; advertising, promotional, publicity and marketing services; advertising of arts events, conferences and business events; advisory, consultancy and information services relating to all of the aforesaid services. Publishing services; publishing of electronic publications; electronic publishing services; provision of information relating to teaching, instruction and education; provision of online-electronic publications; teaching, instructional and educational services relating to the English language; publishing services provided by means of the Internet and world-wide web; providing information regarding the English language, teaching, instruction and education by means of the Internet; Educational assessment services; academic services; education services; teaching services; university services; university education services; educational research; education information services; provision of information concerning education; provision of information relating to teaching, instruction and/or research; examination services; provision of examinations; provision of examination facilities; management of education services; vocational guidance services; organising of conferences, workshops, symposiums, congresses and seminars; organising of exhibitions; provision of correspondence courses, distance learning courses and e-learning training courses; advisory services relating to education; awarding of educational qualifications; conferral of degrees; conducting correspondence courses; teaching, lecturing and tutorial services; library services; museum services; provision of sporting, cultural and entertainment activities; physical education; providing sports facilities; sports coaching; sports training; sporting activities; sports education services; organising of sports events; arranging of concerts; providing facilities for plays and concerts; advisory, consultancy and information services relating to all of the aforesaid services. Computer and information technology consultancy services; research services; research and development for others; scientific and technological research services; industrial analysis and research services; laboratory research; facilitation of research services; provision of access to laboratory equipment for facilitation of scientific research by third parties; provision of research infrastructure; provision of access for third parties to laboratory production and experimental facilities; development of new technology for others; rental of facilities and equipment for technological and scientific testing purposes; information technology consulting services; clinical trials; clinical research; clinical outcome assessment services; medical research; medical laboratory services; design and development of medical diagnostic apparatus; design and development of medical technology; electronic storage of medical records; providing medical and scientific research information in the field of pharmaceuticals and clinical trials; providing information about the results of clinical trials for pharmaceutical products; computer aided diagnostic testing services; design and development of computer hardware and software; software research; software as a service; cloud computing services; rental of software platform as a service; hosting of digital content on the internet; hosting of computerised data, files, applications and information; creating, maintaining and hosting websites; data migration services; data storage; electronic storage of files and documents; preparation and compilation, including analysis, evaluation and presentation of technical and statistical data; consultancy and advisory services for the development and support of technology transfer; consultancy and advisory services for the development and support of knowledge transfer; arrangement of analysis and testing of materials; scientific research for medical purposes; medical laboratory services; advisory, consultancy and information services relating to all of the aforesaid services. Services for providing food and drink; cafes; cafeterias; canteens; catering services; restaurants; self-service restaurants; snack-bars; rental of temporary accommodation; accommodation bureaux; temporary accommodation reservations; providing facilities for exhibitions; hotel reservations; hotels; providing hotel accommodation; advisory, consultancy and information services relating to all of the aforesaid services. Hospital services; hospice services; health care services; health screening services; health diagnosis services; health risk assessment surveys; clinic services; clinical services; medical services; medical care; medical treatment services; medical services relating to dermatology, cardiology, and/or oncology; medical counselling; medical evaluation services; medical testing services; medical services for the treatment of the skin; dentistry services; nursing care services; medical analysis for the diagnosis and treatment of persons; therapy services; x-ray services; ophthalmology services; psychological testing; psychiatric testing; genetic testing for medical purposes; pathology services; human tissue bank services; plastic surgery; psychiatry services; speech therapy services; fertility treatment services; health counselling; physiotherapy; pharmacy advice; pharmacy services; surgical services; outpatient medical advice; medical health and fitness assessment services; provision of vaccination for overseas travel; provision of medical information; provision of health care information; health information and advisory services; advisory, consultancy and information services relating to all of the aforesaid services. Licensing of research and development; legal services; intellectual property consultancy services; consultancy services relating to the filing and prosecution of applications for registration of intellectual and industrial property rights; licensing of intellectual property rights; advisory services relating to the licensing and infringement of intellectual property rights; licensing of patents, copyright and intellectual property; company formation services; pastoral counselling; advisory, consultancy and information services relating to all of the aforesaid services.

Produits et services

(1) Publishing services, namely, publishing of electronic publications; electronic desktop publishing; provision of online electronic publications; online publishing services, namely online publishing of electronic publications; publication of electronic books and journals online; providing on-line publications on the internet, namely text books, journals, study notes; consultancy, information and advisory services all relating to the publishing of electronic publications in the field of politics and international relations.

Produits et services

Publishing services, publishing of electronic publications; electronic publishing services; provision of online electronic publications; publishing services provided by means of the internet and world-wide web; publishing by electronic means; publication of electronic books and journals online; providing on-line publications [not downloadable]; consultancy, information and advisory services all relating to the aforesaid; all the aforesaid relating to politics and international relations.

Abrégé

Embodiments of a system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.

Classes IPC  ?

• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p.ex. par les adjuvants chimiques

Produits et services

rice; foodstuffs made of rice, namely, rice based snack foods, rice biscuits, rice cakes, rice chips, rice crackers, crusts of overcooked rice (nurungji), rice flour, rice and seasoning mixes combined in unitary packages, edible rice paper, cooked rice, rice pudding, rice pulp for culinary purposes, rice salads, rice sticks, rice tapioca, and rice-based dumplings; prepared meals consisting primarily of rice; and packaged meal mixes consisting primarily of rice; none of the foregoing being coffee or tea substitutes unprocessed rice; agricultural, horticultural, and forestry products and grains not included in other classes, namely, unprocessed barley, unprocessed beans, dried plants, unprocessed edible nuts, unprocessed edible seeds, and unprocessed wheat; and natural plants and flowers scientific and technological services, namely, scientific research, testing, and analysis in the fields of agriculture, horticulture, and forestry; industrial chemical analysis and scientific research services in the fields of agriculture, horticulture, and forestry; and professional scientific research consulting services and scientific research advice about agriculture, horticulture, and forestry

Produits et services

(1) Rice; rice-based snack food; Unprocessed rice; seeds for agriculture, natural plants and flowers (1) Scientific and technological services and research and design relating thereto, in the field of rice research, analysis, development and growth; industrial analysis and research services, in the field of rice research, analysis, development and growth, advice and information relating to the aforesaid, all in the field of agriculture, horticulture and forestry

Abrégé

The present invention provides antibodies, for use in the treatment, suppression prevention of Filovirus disease, particularly Ebola virus disease. Also provided immunogens for use in eliciting such antibodies.

Classes IPC  ?

• A61K 39/12 - Antigènes viraux
• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61P 31/00 - Agents anti-infectieux, c. à d. antibiotiques, antiseptiques, chimiothérapeutiques

Abrégé

A method of localising portable apparatus (200) obtains: a stored experience data set comprising a set of connected nodes; captured location representation data provided by at least one sensor associated with the portable apparatus, and a current pose estimate of the portable apparatus within the environment. The pose estimate is used to select a candidate set of the nodes that contain a potential match for the captured location representation data. The pose estimate is used to obtain a set of paths from path memory data, each said path comprising a set of said nodes previously traversed in the environment under similar environmental/visual conditions. The set of paths is used to refine the candidate set. The captured location representation data and the refined candidate set of nodes is compared in order to identify a current pose of the portable apparatus within the environment.

Classes IPC  ?

• G01S 5/16 - Localisation par coordination de plusieurs déterminations de direction ou de ligne de position; Localisation par coordination de plusieurs déterminations de distance utilisant des ondes électromagnétiques autres que les ondes radio
• G05D 1/02 - Commande de la position ou du cap par référence à un système à deux dimensions
• G01C 21/28 - Navigation; Instruments de navigation non prévus dans les groupes spécialement adaptés pour la navigation dans un réseau routier avec corrélation de données de plusieurs instruments de navigation

Abrégé

A method of localising portable apparatus (100) in an environment, the method comprising obtaining captured image data representing an image captured by an imaging device (106) associated with the portable apparatus, and obtaining mesh data representing a 3-dimensional textured mesh of at least part of the environment. The mesh data is processed to generate a plurality of synthetic images, each synthetic image being associated with a pose within the environment and being a simulation of an image that would be captured by the imaging device from that associated pose. The plurality of synthetic images is analysed to find a said synthetic image similar to the captured image data, and an indication is provided of a pose of the portable apparatus within the environment based on the associated pose of the similar synthetic image.

Classes IPC  ?

• G06T 7/00 - Analyse d'image

Abrégé

The invention relates to methods for inducing an immune response against malaria, in particular methods for immunisation against malaria comprising administration of: i) a circumsporozoite (CS) antigen, which is a CS protein or an immunogenic fragment or variant thereof and ii) a nucleotide vector encoding a thrombospondin-related adhesive protein (TRAP) antigen, which is a TRAP protein or an immunogenic fragment or variant thereof.

Classes IPC  ?

• A61K 39/015 - Antigènes d'Hemosporidia, p.ex. antigènes de Plasmodium

Produits et services

Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices; toiletries; aftershave. DVDs; CD-roms; electronic publications; digital media and recordings; pre-recorded digital media and recordings; downloadable electronic publications; electronic publications delivered online through a web-browser or as a downloadable application or application delivered to any computing device including desktop, laptop and tablet computers as well as mobile devices; downloadable digital media and recordings; downloadable digital media and recordings containing sound, images, text, information, signals or software; webcasts; teaching apparatus and instruments; audio and visual teaching apparatus; electronic databases; downloadable digital media and recordings containing teaching apparatus and instruments; computer games; educational computer games; downloadable computer games; computer software and computer programs containing educational material or intended for educational purposes; downloadable software and applications; software applications delivered online through a web-browser or as a downloadable application or application delivered to any computing device including desktop, laptop and tablet computers as well as mobile devices; animated cartoons and other imagery apparatus and instruments all for the recording, reproduction or transmission of sound, images, video and data; cinematographic films; animated cartoons; film strips; movies; magnetic recordings; optical recordings; magneto-optical recordings; solid-state recordings;  multimedia discs and publications; multimedia recordings and publications; recording disks; compact discs-interactive CD-roms; communications apparatus and instruments; telephones; mobile phones; chargers; chargers for mobile phones; hands-free apparatus for mobile phones; mobile phone games; mobile phone covers and cases; karaoke machines; digital games, mobile phone games; DVD games; pre-recorded audio and video compact discs, DVDs, motion picture films, television programmes and other digital recording media; musical sound recordings; glasses; sunglasses; parts and fittings for all the aforesaid goods. Precious metals and their alloys; jewellery; bracelets; brooches; cufflinks; earrings; necklaces; rings; precious stones; watches; watch straps; clocks;  jewellery boxes. Paper; cardboard and goods made from these materials, namely postcards, calendars, diaries, cardboard cut-outs and/or works of art; printed matter; books; annuals; note books; publications; comic books; song books; magazines; newsletters; newspapers; albums; periodicals; journals; text books; catalogues; manuals; maps; pamphlets; leaflets; posters and charts; stationery; labels; office requisites; drawing and painting materials, apparatus and instruments; writing instruments; instructional and teaching materials; instructional and teaching materials for education and information; book binding materials; book covers; book marks; printing sets; drawings; paintings; photographs; prints; pictures; calendars; pens; pencils; pencil top ornaments; paintbrushes; paint kits; tags; gift wrap; gift wrap cards; gift wrap tissue; gift boxes; wrapping paper; note pads; decalcomanias; paper napkins;  paper party goods and paper party decorations; paper tablecloths and table covers; paper mats; paper party streamers; embroidery patterns; decorative transfers; temporary tattoos; rulers; erasers; greetings cards; stickers; paper signs; banners; charts; packaging materials; parts and fittings for all the above goods. Leather and imitations of leather; luggage; trunks and travelling bags; rucksacks; umbrellas and parasols; walking sticks; briefcases; wallets; purses; bags. Furniture; mirrors, picture frames and photograph frames;  cushions;  door stops; hampers. Household and kitchen utensils and containers; combs and sponges; lunch boxes; cups; crockery; bowls; cutlery trays; wash bags; cosmetic bags; oven gloves; oven mitts; glassware, porcelain and earthenware not included in other classes. Textiles;  cloth; bed linen; covers for cushions; blankets; sheets; goods of cloth not included in other classes; towels; tea towels; glass cloths; dish cloths; flannels; table linen; table cloths, table napkins; serviettes; table mats; napery (textile); table runners; washing mitts; filtering materials of cloth; cheese cloth; muslin; gauze (cloth); handkerchiefs; place mats. Clothing, footwear, headgear. Games, toys and playthings; electronic games; electrical and video amusement apparatus and instruments; gymnastic and sporting articles not included in other classes;  amusement apparatus adapted for use with television receivers; interactive games adapted for use with television receivers. Entertainment; sporting and cultural activities; publishing services; publishing of electronic publications; publishing services carried out by computerised means; publishing by electronic means; publication of electronic books and journals online; providing on-line publications (not downloadable); electronic publication services; provision of information relating to teaching, instruction and education; provision of online-electronic publications; teaching, instructional and educational services relating to the English language; teaching, instruction and education by means of the Internet; providing information regarding the English language, teaching, instruction and education by means of a computer database; academic services provided by universities, university services; conferral of degrees; arranging and conducting seminars; symposiums, conferences and congresses, conducting correspondence courses; teaching, lecturing and tutorial services; educational and training services; providing information concerning education; educational examinations; organisation of exhibitions for educational purposes; lending libraries and library services; museum services; rental of educational apparatus and instruments; provision of educational, teaching, tutorial and instructional services by means of telecommunications; provision of educational, teaching, tutorial and instructional services regarding the English language by means of the internet; provision of educational, teaching, tutorial and instructional services regarding the English language electronically; courses using distance learning methods; organisation and provision of courses relating to the English language using distance learning methods; theme park services; amusement park services; provision of educational services via electronic media, multimedia content, videos, movies, television programmes, pictures, images, text, photos, user-generated content, audio content, and related information via the Internet and other communications networks; organisation of events, exhibitions, cultural activities, competitions and stage shows; production, presentation, rental and distribution of films, television and radio programmes; interactive entertainment services in relation to films, sound and video recordings, educational and instructional materials, all in the fields of music, cultural activities, movies and television programmes; online entertainment and digital publishing services; providing television programmes and films online; advisory, consultancy and information services in respect of the aforesaid services.

Abrégé

A method and system for determining extrinsic calibration parameters for at least one pair of sensing devices mounted on transportable apparatus obtains (202) image data (110) representing images captured by an image generating sensing device (102) of the pair at a series of poses during motion through an environment (120) by transportable apparatus (100). The method obtains (202) data (112) representing a 3D point cloud based on data produced by a 2D LIDAR sensing device (104) of the pair. The method selects (204) an image captured by the image at a particular pose. The method generates (210) a laser reflectance image based on a portion of the point cloud corresponding to the pose. The method computes (212) a metric measuring alignment between the selected image and the corresponding laser reflectance image and uses (214) the metric to determine extrinsic calibration parameters for at least one of the sensing devices.

Classes IPC  ?

• H04N 7/18 - Systèmes de télévision en circuit fermé [CCTV], c. à d. systèmes dans lesquels le signal vidéo n'est pas diffusé
• G06T 7/80 - Analyse des images capturées pour déterminer les paramètres de caméra intrinsèques ou extrinsèques, c. à d. étalonnage de caméra
• G06T 5/00 - Amélioration ou restauration d'image
• H04N 13/02 - Générateurs de signaux d'image
• G01S 17/02 - Systèmes utilisant la réflexion d'ondes électromagnétiques autres que les ondes radio
• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G01S 7/48 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
• G01S 7/497 - Moyens de contrôle ou de calibrage

Abrégé

Typhi indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided.

Classes IPC  ?

• A61K 39/112 - Salmonella; Shigella
• A61K 39/02 - Antigènes bactériens
• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques

Abrégé

Navigation data is generated by receiving (502) a new experience data set (321) relating to a new experience capture. At least one stored experience data set (320) relating to at least one previous experience capture is also received (504). An experience data set includes a set of nodes, with each node comprising a series of visual image frames taken over a series of time frames. A candidate set of said nodes is obtained (506) from the stored experience data set that potentially matches a said node in the new experience data set, and then a check (508) if performed to see if a node in the candidate set matches the node in the new experience data set. If the result of the checking is positive then data relating to the matched nodes is added (510) to a place data set useable for navigation, the place data set indicating that said nodes in different said experience data sets relate to a same place.

Classes IPC  ?

• G05D 1/00 - Commande de la position, du cap, de l'altitude ou de l'attitude des véhicules terrestres, aquatiques, aériens ou spatiaux, p.ex. pilote automatique
• G01C 21/30 - Mise en coïncidence avec des cartes ou des contours
• G05D 1/02 - Commande de la position ou du cap par référence à un système à deux dimensions
• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• G06K 9/66 - Méthodes ou dispositions pour la reconnaissance utilisant des moyens électroniques utilisant des comparaisons ou corrélations simultanées de signaux images avec une pluralité de références, p.ex. matrice de résistances avec des références réglables par une méthode adaptative, p.ex. en s'instruisant
• G09B 29/00 - Cartes; Plans; Graphiques; Tracés, p.ex. tracés de routes

Abrégé

Lipidomic markers for Hepatitis C and related conditions, treat hepatic fibrosis and hepatocellular carcinoma. An agent administered to such subject may be an iminosugar, which may be effective against hepatitis C. Such iminosugar may be, for example, one of N- substituted deoxynojrimycins and pharmaceutically acceptable salts thereof, N-substituted deoxygalactonojirimycins and pharmaceutically acceptable salts thereof and N-substituted Me- deoxygalactonojirimycins and pharmaceutically acceptable salts thereof. A method of assessing a Hepatitis C infection or a condition caused by or associated with said infection. This method comprises: obtaining a biological sample from a subject in need thereof; determining a level of at least one Hepatitis C lipidomic biomarker in said biological sample; and comparing said level of with a control level of said Hepatitis C lipidomic biomarker to assess the Hepatitis C infection or the condition caused by or associated with said infection in the subject.

Classes IPC  ?

• A61K 31/739 - Lipopolysaccharides
• C40B 40/14 - Bibiothèques comprenant des composés macromoléculaires non couvertes par les groupes
• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
• G01N 33/576 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour l'hépatite
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The application provides iminosugars with a high activity and specificity for inhibiting ceramide glucosyltransferase.

Classes IPC  ?

• A01N 43/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons
• A61K 31/45 - Pipéridines non condensées, p.ex. pipérocaïne ayant des groupes oxo liés directement à l'hétérocycle, p.ex. cycloheximide
• A61K 31/445 - Pipéridines non condensées, p.ex. pipérocaïne

Abrégé

Method and apparatus for localizing transportable apparatus (100) within an environment (120) includes obtaining (202) point cloud data (114) representing a 3D point cloud with appearance information of at least part of the environment. The method further obtains (204) first frame data (110) representing an image produced by a sensor (102) onboard transportable apparatus at a first time and location within the environment and second frame data (110) representing an image produced by the sensor at a second time and location within the environment. The method harmonizes (206) information about the first frame data, the second frame data and an overlapping subset of the point cloud data in order to determine a location within the point cloud data where at least one of the first frame and the second frame was produced, thereby localizing (208) the transportable apparatus within the environment.

Classes IPC  ?

• G06T 7/77 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés statistiques
• H04N 7/18 - Systèmes de télévision en circuit fermé [CCTV], c. à d. systèmes dans lesquels le signal vidéo n'est pas diffusé
• G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
• G06T 7/11 - Découpage basé sur les zones
• G06T 7/254 - Analyse du mouvement impliquant de la soustraction d’images

Abrégé

Disclosed is a process and device allowing for fast measurements of the physicochemical properties of amphiphiles (lipids, surfactants, soaps,...). A Marangoni flow is created and characterized using amphiphiles to be characterized. The observed flow is characterized, and using the disclosed process, one can deduce from this measurement many important physicochemical parameters of the amphiphiles such as their critical micellar concentration. Compared to existing techniques, the disclosed process offers the advantage that it requires a single experiment to deduce the parameters, when other techniques (pendant drop method, conductometry, etc...) require the measurement of a quantity (interfacial tension, conductometry) against a systematically varied parameter (amphiphile concentration,...). The disclosed process and devices are ideal to characterize and/or screen rapidly amphiphiles molecules based on their interaction with a solvent.

Classes IPC  ?

• G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
• G01N 13/02 - Recherche de la tension superficielle des liquides

Produits et services

Pre-recorded audio and/or video cassettes; compact discs (read only memory); computer software; floppy discs; electronic databases; downloadable software and applications; software applications delivered online through a web-browser or as a downloadable application or application delivered to any computing device including desktop, laptop and tablet computers as well as mobile devices; electronic publications delivered online through a web-browser or as a downloadable application or application delivered to any computing device including desktop, laptop and tablet computers as well as mobile devices; all the aforementioned for English language teaching purposes. Instructional and teaching materials (except apparatus), books, journals, text books, magazines, posters and charts; all for English language teaching purposes. Providing on-line publications (not downloadable) for the teaching of English language; publishing, electronic publishing; teaching, instructional and educational services relating to the English language; qualification, testing, assessment and examinations services relating to English language education; instruction and education by means of the Internet relating to the English language; providing information regarding the teaching of English language; instruction and education by means of a computer database relating to the English language.

Abrégé

Provided are assays, kits and compositions for testing subjects, particularly asymptomatic subjects, to ascertain whether or not they are carriers of Salmonella enterica serotype Typhi. Methods for detecting the presence of Salmonella enterica serotype Typhi indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided.

Classes IPC  ?

• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
• G01N 33/577 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet faisant intervenir des anticorps monoclonaux
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
• C12R 1/42 - Salmonella

Abrégé

A method and system for determining extrinsic calibration parameters for at least one pair of sensing devices mounted on transportable apparatus obtains (202) image data (110)representing images captured by an image generating sensing device (102) of the pair at a series of poses during motion through an environment (120) by transportable apparatus (100). The method obtains (202) data (112) representing a 3D point cloud based on data produced by a 2D LIDAR sensing device (104) of the pair. The method selects (204) an image captured by the image at a particular pose. The method generates (210) a laser reflectance image based on a portion of the point cloud corresponding to the pose. The method computes (212) a metric measuring alignment between the selected image and the corresponding laser reflectance image and uses (214) the metric to determine extrinsic calibration parameters for at least one of the sensing devices.

Classes IPC  ?

• G01S 7/497 - Moyens de contrôle ou de calibrage
• G01S 3/78 - Radiogoniomètres pour déterminer la direction d'où proviennent des ondes infrasonores, sonores, ultrasonores ou électromagnétiques ou des émissions de particules sans caractéristiques de direction utilisant des ondes électromagnétiques autres que les ondes radio

Abrégé

The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype.

Classes IPC  ?

• A61K 31/45 - Pipéridines non condensées, p.ex. pipérocaïne ayant des groupes oxo liés directement à l'hétérocycle, p.ex. cycloheximide
• A61K 31/7008 - Composés ayant un groupe amino lié directement à un atome de carbone du radical saccharide, p.ex. D-galactosamine, ranimustine
• C07D 211/46 - Atomes d'oxygène liés en position 4 comportant un atome d'hydrogène comme second substituant en position 4
• A61K 31/513 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p.ex. cytosine
• C07J 43/00 - Stéroïdes normaux ayant un hétérocycle contenant de l'azote non condensé ou condensé en spiro avec le squelette du cyclopenta[a]hydrophénanthrène
• C07D 211/94 - Atome d'oxygène, p.ex. N-oxyde de pipéridine
• A61K 31/7072 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides  contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p.ex. cytidine, acide cytidylique ayant deux groupes oxo liés directement au cycle pyrimidine, p.ex. uridine, acide uridylique, thymidine, zidovudine
• A61K 31/661 - Acides du phosphore ou leurs esters n'ayant pas de liaison P-C, p.ex. fosfosal, dichlorvos, malathion
• A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p.ex. cholane, cholestane, ergostérol, sitostérol
• C07D 473/16 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 deux atomes d'azote
• A61K 31/708 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides  contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p.ex. adénosine, acide adénylique ayant des groupes oxo liés directement au système cyclique purine, p.ex. guanosine, acide guanylique
• C07J 7/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone
• C07H 19/20 - Radicaux purine avec le radical saccharide estérifié par des acides phosphoriques ou polyphosphoriques
• A61K 31/6615 - Composés ayant plusieurs groupes d'acide du phosphore estérifiés, p.ex. triphosphate d'inositol, acide phytique
• A61K 31/197 - Acides carboxyliques, p.ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p.ex. acide gamma-aminobutyrique (GABA), bêta-alanine, acide epsilon-aminocaproïque, acide pantothénique
• C07H 19/06 - Radicaux pyrimidine
• A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p.ex. phosphate de pyridoxal
• A61K 31/445 - Pipéridines non condensées, p.ex. pipérocaïne
• A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
• A61K 31/5375 - 1,4-Oxazines, p.ex. morpholine
• A61K 31/7012 - Composés ayant un groupe carboxyle libre ou estérifié, lié directement ou par une chaîne carbonée, à un atome de carbone du radical saccharide, p.ex. acide glucuronique, acide neuraminique
• A61K 31/685 - Diesters d'acide du phosphore avec deux composés hydroxyle, p.ex. phosphatidylinositols  un des composés hydroxylés ayant des atomes d'azote, p.ex. phosphatidylsérine, lécithine
• A61K 31/42 - Oxazoles
• A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes contenant des hétérocycles, p.ex. danazol, stanozolol, pancuronium ou digitogénine
• A61K 31/431 - Composés contenant des systèmes cycliques thia-4 aza-1 bicyclo [3.2.0] heptane, c.à d. composés contenant un système cyclique de formule , p.ex. pénicillines, pénèmes contenant d'autres systèmes hétérocycliques, p.ex. ticarcilline, azlocilline, oxacilline
• A61K 31/52 - Purines, p.ex. adénine
• A61K 31/195 - Acides carboxyliques, p.ex. acide valproïque ayant un groupe amino

Abrégé

Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase δ (RPTPδ), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTPδ and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTPδ. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTPδ. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.

Classes IPC  ?

• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 38/18 - Facteurs de croissance; Régulateurs de croissance
• A61K 49/00 - Préparations pour examen in vivo
• C07K 14/475 - Facteurs de croissance; Régulateurs de croissance
• C07K 14/48 - Facteur de croissance des nerfs (NGF)
• C07K 14/00 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
• A61K 31/727 - Héparine; Héparane
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• A61K 31/737 - Polysaccharides sulfatés, p.ex. sulfate de chondroïtine, sulfate de dermatane
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains

Abrégé

Iminosugar compounds are described that have inbuilt delivery features by virtue of covalent incorporation of a tocopherol moiety, or alternative moieties that are analogues of tocopherol or select analogues of cholesterol, or its antagonist "Ezitimibe"; and are likely to have broad spectrum antiviral activity. The compounds differ from previous iminosugar compounds, even lipophillic ones, being more hydrophobic and resembling fats and oils in their partition behavior in vivo into lipid phases of lipoproteins, cellular lipid droplet organelles and biological membranes. These features confer a number of unique delivery attributes in vivo, favorable to the therapy of virus infections involving cells of the lymphoid system and the liver, in particular, but these features are also favorable in general for the treatment of virus infections of man and animals.

Classes IPC  ?

• A61K 31/355 - Tocophérols, p.ex. vitamine E
• A61K 31/445 - Pipéridines non condensées, p.ex. pipérocaïne
• A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p.ex. cholane, cholestane, ergostérol, sitostérol
• A61P 31/12 - Antiviraux

Abrégé

A method of localising transportable apparatus (200) within an environment includes receiving (402) data obtained from a first ranging sensor device (202) that is configured to collect information relating to a 2D representation of an environment (301) through which the transportable device is moving. Further data is received (404), that data being obtained from a second ranging sensor device (204) of the transportable apparatus configured to collect information relating to at least a surface (218) over which the transportable apparatus is moving. The ranging sensor device data is used (406) to estimate linear and rotational velocities of the transportable apparatus and the estimates are used (408) to generate a new 3D point cloud (212) of the environment. The method seeks to match (412) the new 3D point cloud with, or within, existing 3D point cloud (216) in order to localise the transportable apparatus with respect to the existing point cloud.

Classes IPC  ?

• G01S 17/87 - Combinaisons de systèmes utilisant des ondes électromagnétiques autres que les ondes radio
• G01S 17/58 - Systèmes de détermination de la vitesse ou de la trajectoire; Systèmes de détermination du sens d'un mouvement
• G01S 7/48 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G06T 7/00 - Analyse d'image
• G01C 21/00 - Navigation; Instruments de navigation non prévus dans les groupes

Abrégé

Navigation data is generated by receiving (502) a new experience data set (321 ) relating to a new experience capture. At least one stored experience data set (320) relating to at least one previous experience capture is also received (504). An experience data set includes a set of nodes, with each node comprising a series of visual image frames taken over a series of time frames. A candidate set of said nodes is obtained (506) from the stored experience data set that potentially matches a said node in the new experience data set, and then a check (508) if performed to see if a node in the candidate set matches the node in the new experience data set. If the result of the checking is positive then data relating to the matched nodes is added (510) to a place data set useable for navigation, the place data set indicating that said nodes in different said experience data sets relate to a same place.

Classes IPC  ?

• G01C 21/30 - Mise en coïncidence avec des cartes ou des contours
• G05D 1/02 - Commande de la position ou du cap par référence à un système à deux dimensions
• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• G09B 29/00 - Cartes; Plans; Graphiques; Tracés, p.ex. tracés de routes

Abrégé

Described herein are methods of evaluating metastatic potential of a cancer based on the phosphorylation state and/or intracellular localization of iASPP. Therapeutic regimens designed based on the results of the diagnostic methods are also provided.

Classes IPC  ?

• C07K 16/00 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
• C07K 14/00 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention provides influenza peptide antigens which may be used to induce T cell responses, and not only to the particular influenza strain from which peptide antigen was derived, but also to peptides derived from other influenza strains. These peptides, and vaccines comprising these peptides, are useful in inducing T cell immunity to influenza and advantageously the T cell immunity is to more than one type of influenza.

Classes IPC  ?

• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
• C07K 14/11 - Orthomyxoviridae, p.ex. virus de l'influenza

Abrégé

Disclosed herein are α-galactosylceramide (α-GalCer) analogs and compositions thereof, methods of activating invariant Natural Killer T (iNKT) cells using said analogs, methods of treating diseases by activating iNKT cells using said analogs, and combination therapy of said analogs.

Classes IPC  ?

• C07C 233/18 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone acyclique ayant l'atome de carbone du groupe carboxamide lié à un atome d'hydrogène ou à un atome de carbone d'un squelette carboné acyclique saturé
• A61K 31/16 - Amides, p.ex. acides hydroxamiques
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to medicaments for the treatment of cystic fibrosis. Also provided are methods of preparing such medicaments so that they can be used in a treatment regime for cystic fibrosis. The present invention also provides a kit of parts including the medicament of the invention, as well as treatment regimes for cystic fibrosis.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol

Abrégé

A method of localising transportable apparatus (100) within an environment including receiving (402) data obtained from a 2D ranging sensor device (102) of the transportable apparatus configured to collect information relating to at least a surface (120) over which the transportable apparatus is moving in an environment, and using (404) the ranging sensor device data to generate a new 3D point cloud (110) of the environment. The method further obtains (406) data representing an existing 3D point cloud (114) of at least part of the environment, and seeks to match (408) the new 3D point cloud with, or within, the existing 3D point cloud in order to localise the transportable apparatus with respect to the existing point cloud.

Classes IPC  ?

• G01S 7/497 - Moyens de contrôle ou de calibrage
• G01S 17/06 - Systèmes déterminant les données relatives à la position d'une cible
• G01S 17/88 - Systèmes lidar, spécialement adaptés pour des applications spécifiques
• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G01C 21/16 - Navigation; Instruments de navigation non prévus dans les groupes en utilisant des mesures de la vitesse ou de l'accélération exécutées à bord de l'objet navigant; Navigation à l'estime en intégrant l'accélération ou la vitesse, c. à d. navigation par inertie
• G01C 21/30 - Mise en coïncidence avec des cartes ou des contours
• G05D 1/02 - Commande de la position ou du cap par référence à un système à deux dimensions

Abrégé

Method and apparatus for localising transportable apparatus (100) within an environment (120) includes obtaining (202) point cloud data (114) representing a 3D point cloud with appearance information of at least part of the environment. The method further obtains (204) first frame data (110) representing an image produced by a sensor (102) onboard transportable apparatus at a first time and location within the environment and second frame data (110) representing an image produced by the sensor at a second time and location within the environment. The method harmonises (206) information about the first frame data, the second frame data and an overlapping subset of the point cloud data in order to determine a location within the point cloud data where at least one of the first frame and the second frame was produced, thereby localising (208) the transportable apparatus within the environment.

Classes IPC  ?

• G06T 7/00 - Analyse d'image

Abrégé

A method of determining extrinsic calibration parameters for at least one sensor (102, 104, 106) mounted on transportable apparatus (100). The method includes receiving (202) data representing pose history of the transportable apparatus and receiving (202) sensor data from at least one sensor mounted on transportable apparatus. The method generates (204) at least one point cloud data using the sensor data received from the at least one sensor, each point in a said point cloud having a point covariance derived from the pose history data. The method then maximises (206) a value of a quality function for the at least one point cloud, and uses (208) the maximised quality function to determine extrinsic calibration parameters for the at least one sensor.

Classes IPC  ?

• G01S 7/497 - Moyens de contrôle ou de calibrage
• G01S 17/87 - Combinaisons de systèmes utilisant des ondes électromagnétiques autres que les ondes radio
• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G01S 7/48 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
• G06T 7/00 - Analyse d'image

Abrégé

A method and apparatus are disclosed for localizing a vehicle along a route. The method comprises initially surveying the route to be traversed by the vehicle by creating a plurality of orthographic images of the route, at a plurality of locations along the route and subsequently passing the vehicle along the route while obtaining a current view of the route. The method further comprises resolving a pose of the vehicle relative to a survey trajectory by maximising a relation between the orthographic images and the current view.

Classes IPC  ?

• G01C 11/12 - Restitution des photos par comparaison de plusieurs photos de la même zone les photos étant placées dans la même position relative qu'au moment où elles ont été prises
• G01C 21/00 - Navigation; Instruments de navigation non prévus dans les groupes
• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• G06T 7/20 - Analyse du mouvement

Produits et services

Published material in digital format; optical, electronic and magnetic data storage media bearing recorded information; downloadable sounds, downloadable images, downloadable text; downloadable sounds, downloadable images, downloadable text and information provided by telecommunications networks, by online delivery and by way of the Internet and the world wide web; computer software; downloadable electronic publications; downloadable software applications for use on portable electronic devices; information stored in electronic, digital and magnetic form; downloadable publications in electronic form, supplied on-line from databases or from facilities provided on the Internet. Paper, cardboard and goods made from these materials, not included in other classes; printed matter; photographs; stationery; adhesives for stationery or household purposes; artists' materials; paint brushes; notebooks; notecards; books; postcards; greeting cards; calendars; maps; prints of artistic works; bookmarks; paper; writing sets; labels; pens; pencils; posters. Museum services; curation of museums; running of museums; operation of museum exhibitions; provision of museum facilities for presentations and exhibitions; educational and entertainment activities; educational services; providing information on museum exhibits; providing information pertaining to literary and artistic works; providing information pertaining to literary and artistic works by means of computer software; organisation and provision of training, conferences, congresses, cultural and entertainment activities; educational and training services; provision of information concerning museums.

Produits et services

Audio and video cassettes; floppy discs bearing computer software; CD RAMS; CD ROM'S DVDs; DVD-ROMs; CDs; published material in digital format; optical, electronic and magnetic data storage devices bearing recorded information; digital and analogue media for recording, reproducing, carrying, storing, processing, manipulating, transmitting, broadcasting, retrieving and reproducing downloadable music, downloadable sounds, downloadable images, downloadable text; downloadable sounds, downloadable images, downloadable text and information provided by telecommunications networks, by online delivery and by way of the Internet and the world wide web; computer programs; computer software for teaching, instructional and educational purposes; downloadable electronic publications; electronic databases; apparatus and instruments; all for recording and reproducing sound or video; blank and pre-recorded sound and video recording materials; information stored in electronic, digital and magnetic form; downloadable publications in electronic form, supplied on-line from databases for from facilities provided on the Internet; downloadable software and applications; software applications delivered online through a web-browser or as a downloadable application or application delivered to any computing device including desktop, laptop and tablet computers as well as mobile devices; parts and fittings for the aforesaid goods. Paper, paper article, cardboard and cardboard articles, books, printed matter; instructional and teaching materials; journals; periodicals; newspapers; printed sheet music; bibles; magazines, maps, posters and charts, photographs. Publishing services; publishing of electronic publications; electronic publishing services; provision of information relating to teaching, instruction, research and education; provision of online-electronic publications; teaching, instructional and educational services relating to the English language; publishing services provided by means of the Internet and world-wide web; providing information regarding the English language, teaching, research, instruction and education by means of the Internet; providing information regarding the English language, teaching, research, instruction and education by means of a computer database; academic services provided by universities; university services; conferral of degrees; arranging and conducting seminars, symposiums, conferences and congresses; conducting correspondence courses; teaching, lecturing and tutorial services; educational and training services; providing information concerning education; educational examinations; organisation of exhibitions for educational purposes; lending libraries and library services; provision of sporting, cultural and entertainment activities; museum services; rental of educational apparatus and instruments; information and advisory services all relating to the aforesaid; all provided by a university.