The present invention is directed to a scaffold for tissue engineering, comprising a support structure having an outer surface, at least a part of the outer surface being covered by a bioactive material layer that allows cell attachment, wherein the bioactive material layer is at least partially degradable in an environment of use, to allow a detachment of the cells from the support structure by degradation of the bioactive material layer. The invention is further directed to the use of an at least partially degradable bioactive material layer on a scaffold for tissue engineering, for allowing detachment of the cells or grown tissue by degradation of the bioactive material layer.
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
The present invention is directed to a curable therapeutic implant composition for use in the filling of a cavity in a living organism, comprising particles of a metallic material, and a curable matrix-forming, non-particulate material, wherein at least one of the metallic material or the matrix-forming material is at least partially degradable in-vivo. Furthermore, the present invention is directed to methods of filling a cavity in a living organism with the use of the curable implant composition.
A61L 27/44 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 31/12 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
3.
PARTIALLY BIODEGRADABLE THERAPEUTIC IMPLANT FOR BONE AND CARTILAGE REPAIR
The present invention is directed to an at least partially biodegradable implant suitable for implantation into a subject for repairing a bone or cartilage defect, comprising a three-dimensional open-celled framework structure made of a non- particulate first material, the framework structure being embedded in a second, non- particulate material different from said first material, or the open-celled framework structure being substantially co mpletely filled with said second, non-particulate material, wherein at least one of the first material or the second material is at least partially degradable in-vivo. Furthermore, the present invention is directed to a method for repairing a bone or cartilage defect in a living organism, comprising implanting an implant according to the invention into the defective bone or cartilage, or replacing the defective bone or cartilage at least partially.
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
A61L 27/44 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
4.
BIODEGRADABLE THERAPEUTIC IMPLANT FOR BONE OR CARTILAGE REPAIR
The present invention is directed to an at least partially biodegradable implant suitable for implantation into a subject for repairing a bone or cartilage defect, comprising a matrix forming an open-celled structure having a plurality of interconnected spaces, wherein the channels of the matrix are substantially completely filled with metallic material particles, and wherein at least one of the metallic material or the matrix material is at least partially degradable in-vivo. Furthermore, the present invention is directed to a method for repairing a bone or cartilage defect in a living organism, comprising implant ing an implant according to the invention into the defective bone or cartilage, or replacing the defective bone or cartilage at least partially.
A61L 27/44 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 31/12 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
The present invention is directed to a reversibly closable vessel for cultivation of cells and/or tissues comprising at least one reversibly closable aperture in the vessel wall, at least one wall in the interior of the vessel, the wall being an integral part of the vessel, and dividing said interior into at least two compartments, wherein the wall comprises at least one of a hole, tube-like hole, opening, or a partially porous structure, allowing the flowing through of fluids from one compartment to another, and at least one of the at least two compartments comprises at least one filler.
C12M 1/16 - Appareillage pour l'enzymologie ou la microbiologie contenant ou adaptés pour contenir des milieux solides
C12M 3/04 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus comportant des moyens fournissant des couches minces
The present invention is directed to a reversibly closable bag for cultivation of cells and/or tissues, comprising at least one reversibly closable aperture in the bag wall, and a surface-increasing convection means inside said bag, the means being capable to generate and/or modify a convection in a fluid within said bag when at least one of the fluid, the bag, and the convection means is agitated, wherein the surface increasing convection means is selected from at least one of at least one blade, at least one particulate filler, or at least one surface-increasing substrate being made of a single mould. The invention further provides a system comprising at least two bags, wherein the bags are interconnected via at least one aperture in their bag wall, and a cultivation process using such a bag or system, in which at least one type of cells, tissue, tissue-like cell cultures, organs, organ-like cell cultures, or multicellular organisms are cultivated in the presence of at least one fluid or solid medium necessary for growing and/or cultivating the aforesaid culture.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/02 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'échange de chaleur
C12M 3/04 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus comportant des moyens fournissant des couches minces
7.
HIGH SURFACE CULTIVATION SYSTEM WITH SURFACE INCREASING SUBSTRATE
The present invention is directed culture vessel suitable for cultivation of cells and/or tissues comprising at least one reversibly clo sable aperture in the vessel wall, and at least one surface-increasing substrate within the vessel, said substrate being made of a single mold. The invention further provides a system comprising at least two vessels being interconnected via at least one aperture in their vessel wall, and a cultivation process using such a vessel or system, in which at least one type of cells, tissue, tissue-like cell cultures, organs, organ- like cell cultures, or multicellular organisms are cultivated in the presence of at least one fluid or solid medium necessary for growing and/or cultivating the aforesaid culture.
C12M 1/16 - Appareillage pour l'enzymologie ou la microbiologie contenant ou adaptés pour contenir des milieux solides
C12M 3/04 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus comportant des moyens fournissant des couches minces
The present invention is directed to a reversibly closable vessel suitable for the cultivation of cells and/or tissues, comprising at least one reversibly closable aperture in the vessel wall, a convection means inside said vessel, said means comprising at least one blade (120) and said means being capable to generate and/or modulate a convection in a fluid within said vessel when at least one of the vessel and the blade is agitated, wherein at least one of the convection means and the blade is at least particularly made from a porous material.
C12M 3/04 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus comportant des moyens fournissant des couches minces
The present invention relates; to a stent, and in particular to an at least partially biodegradable stent having at least one section made of a material having a particular porous structure. The structure comprises a plurality of material particles made of a biodegradable material, which particles are arranged in a matrix structure embedding a plurality of pores thus forming an open porous structure, and wherein the material particles are joined at contact l surf aces to adjacent material particles, wherein the average size of the pores is larger than an average size of the material particles.
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 31/12 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
The present invention relates to a stent having at least one section made of a material having a particular porous structure, capable of an efficient provision of an active agent. According to an exemplary embodiment of the invention there is provided a stent, having at least one section made of a material having a structure comprising a plurality of material particles, which particles are arranged in a matrix structure embedding a plurality of pores thus forming an open porous, structure, wherein the material particles are joined at contact surfaces to adjacent material particles, wherein an average size of the pores is larger than an average size of the material particles.
The present invention is directed to medical implants, such as e.g. stents, which comprise at least one hollow space or lumen within the structural material or structure of the device, other than a pore or pore system, which may be used as a reservoir for a specific amount of active ingredient to be released after implantation into the body.
A61F 2/88 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles les éléments filiformes étant sous forme d’enroulements hélicoïdaux ou en spirale
The present invention is directed to medical implants, such as e.g. stents, which comprise at least one hollow space or lumen within the structural material or structure of the device, other than a pore or pore system, which may be used as a reservoir for a specific amount of active ingredient to be released after implantation into the body.
A61F 2/86 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles
A61F 2/90 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles caractérisés par une structure de type filet ou de type à mailles
A61L 31/12 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61F 2/86 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles
14.
MEDICAL DEVICES WITH EXTENDED OR MULTIPLE RESERVOIRS
The present invention relates to a process for the manufacture of an implantable medical device or a part thereof wherein at least one metallic layer is deposited on a three-dimensional template of the device and at least partially removing the template. Implants can be produced, which have relatively large reservoirs for including an active ingredient, such as a pharmacologically, therapeutically or biologically active agent, a diagnostically active agent, a marker, an absorptive agent, for eluting in- vivo.
C23C 18/16 - Revêtement chimique par décomposition soit de composés liquides, soit de solutions des composés constituant le revêtement, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement; Dépôt par contact par réduction ou par substitution, p.ex. dépôt sans courant électrique
C25D 1/08 - Articles perforés ou foraminés, p.ex. tamis
A61F 2/90 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles caractérisés par une structure de type filet ou de type à mailles
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
The present invention is directed to at least partially degradable implants and methods for the manufacture there of which use powder molding techniques. Specifically, the methods include the steps of providing a suspension comprising a plurality of first particles of at least one organic polymer; a plurality of second particles of at least one metal-based material which is at least partially biodegradable in-vivo; and at least one solvent; wherein the first and second particles are substantially insoluble in the solvent; molding the suspension to form a green body comprising the first particles embedded in a matrix of compressed second particles; removing the first particles from the green body by thermally induced decomposition and/or evaporation; and sintering the green body to form the implant; wherein the step of removing the first particles is performed during sintering.
The present invention relates to an at least partially biodegradable medical implant, comprising a plurality of in-vivo biodegradable organic polymer particles embedded in a matrix of a plurality of compressed metal-based particles, and methods for the manufacture thereof. The implant may be further functionalized by inclusion of active ingredients such as therapeutically active agents or markers.
A61L 27/42 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice inorganique
A61L 29/12 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61L 31/12 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
17.
POROUS, NON-DEGRADABLE IMPLANT MADE BY POWDER MOLDING
The present invention is directed to porous implants and methods for the manufacture thereof which use powder molding techniques. Specifically, the methods include the steps of providing a suspension comprising a plurality of first particles of at least one organic polymer; a plurality of second particles of at least one metal-based material; and at least one solvent; wherein the first and second particles are substantially insoluble in the solvent; molding the suspension to form a green body comprising the first particles embedded in a matrix of compressed second particles; removing the first particles from the green body by thermally induced decomposition and/or evaporation; and sintering the green body to form the implant; wherein the step of removing the first particles is performed during sintering.
Thermoset-based particles and processes for the manufacture thereof can be provided, where the particles may have a spherical or fibrous shape. A reaction mixture can be provided that includes a thermosetting resin, a crosslinker, a surface active agent, and a solvent. The reaction mixture can be an emulsion, a suspension or a dispersion which may optionally be sprayed or electrospun. Crosslinking of the resin can be performed by addition of an initiator or by exposing the reaction mixture to heat and/or radiation to form polymerized particles. The particles may be dried, sintered, pyrolized or carbonized, and/or impregnated with an active agent invention.
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p.ex. poudres
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
19.
PROCESS FOR THE PRODUCTION OF POROUS RETICULATED COMPOSITE MATERIALS
The present invention relates to porous reticulated composite materials and methods for the production thereof. Particularly, the present invention relates to a process for the production of porous composite materials comprising the steps of providing a mixture capable of flowing, comprising at least one inorganic and/or organic reticulating agent; at least one matrix material selected from polymers or polymer mixtures; and solidifying the liquid mixture.
The present invention relates to medical devices, particularly for therapeutic and/or diagnostic purposes, comprising porous reticulated composite materials and methods for the production thereof. Particularly, the present invention relates to a medical device comprising a porous composite material, said material being obtainable by a process comprising the steps of providing a liquid mixture, comprising at least one inorganic and/or organic reticulating agent; and at least one matrix material selected from polymers or polymer mixtures; and solidifying said mixture.
A61L 27/48 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges macromoléculaires
The present invention relates to a process for manufacturing a porous metal- containing material, comprising the steps of providing a composition comprising particles dispersed in at least one solvent, the particles comprising at least one polymer material and at least one metal-based compound; substantially removing the solvent from said composition; substantially decomposing the polymer material, thereby converting the solvent free particles into a porous metal-containing material. The present invention further relates to metal- containing materials produced in accordance with the above process and their use in implantable medical devices.
The present invention is directed to a process for manufacturing a drug delivery material, the process comprising the steps of encapsulating at least one biologically and/or therapeutically active agent in a shell; combining the encapsulated active agent with a sol; and converting the resulting combination into a solid or semi-solid drug delivery material. The invention further comprises drug delivery materials prodicible by such a process, as well as medical implants comprising such drug delivery materials.
A61K 31/337 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p.ex. fungichromine ayant des cycles à quatre chaînons, p.ex. taxol
The present invention relates to a process for the manufacture of metal containing materials or composite materials, the process comprising the steps of encapsulating at least one metal-based compound in a polymeric shell, thereby producing a polymer-encapsulated metal-based compound; and/or coating a polymeric particle with at least one metal-based compound; forming a sol from suitable hydrolytic or non-hydrolytic sol/gel forming components; combining the polymer-encapsulated metal-based compound and/or the coated polymeric particle with the sol, thereby producing a combination thereof; converting the combination into a solid metal containing material.
B01J 13/00 - Chimie des colloïdes, p.ex. production de substances colloïdales ou de leurs solutions, non prévue ailleurs; Fabrication de microcapsules ou de microbilles
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 33/00 - Préparations médicinales contenant des ingrédients actifs inorganiques
The present invention relates to a process of producing composite materials by a sol/gel-process, comprising carbon nanoparticles and organic polymer material. The invention further relates to composite materials, which are manufactured with the use of said sol/gel technology.
brevets