The present invention generally relates to the biotechnology engineering, and specifically to genetically engineered microorganisms, e.g. of the genus Methylobacillus, which have improved properties making them particularly useful in large scale methanol fermentations. More specifically, the present invention provides a genetically engineered microorganism which is methylotrophic and can generate reducing power by methanol dissimilation, and which microorganism being modified to enable the synthesis of at least one DHAP-derived compound. The present invention further provides a method for producing a biochemical compound using a genetically modified bacterium of the present invention.
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
The present invention relates to means and methods comprising a bacterial heme peroxidase and/or a functional fragment thereof for medical and non-medical use in preventing and/or controlling a pathogen on food, plants, or in or on the human or animal body. The present invention thus relates to novel medical and non-medical uses of a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants, or on the human or animal body. Furthermore, the present invention relates to corresponding methods comprising a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants or on or in the human or animal body comprising applying a sufficient amount of the bacterial heme peroxidase and/or a functional fragment thereof on said food, plants, or on mucosae, skin, in particular epidermal skin like scalp or facial skin and/or teeth to reduce the number of cells of said pathogen. In addition, the invention relates to specific heme peroxidases that have been identified to have desired properties. The invention also relates to fragments of or small heme peroxidases that have particularly advantageous properties. Moreover, the present invention further relates to corresponding compositions comprising a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants, or in or on the human or animal body. Kits comprising components used in the methods and compositions of the invention are also provided herein. Furthermore, provided is the use of a bacterial heme peroxidase and/or of a functional fragment thereof for the preparation of the compositions of the present invention. The present invention finally also relates to a method for producing a bacterial heme peroxidase protein and/or a functional fragment thereof in an engineered Bacillus subtilis strain. The inventive use of the bacterial heme peroxidase of the present invention and/or a functional fragment thereof for preventing and/or controlling a pathogen is, without being limiting, particularly useful in ecologically compatible commercial plant/crop protection campaigns as well as in daily personal care products such as toothpaste for example.
A01N 59/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des éléments ou des composés inorganiques
The present invention generally relates to the biotechnology engineering, and specifically to genetically modified bacteria of the genus Methylobacillus which have improved properties making them particularly useful in large scale methanol fermentations. More specifically, the present invention provides a bacterium of the genus Methylobacillus which has been modified to have a decreased production of exopolysaccharides (EPS) compared to an otherwise identical bacterium that does not carry said modification. The present invention further provides a method for producing a biochemical compound using a genetically modified bacterium of the present invention.
The present invention generally relates to the biotechnology engineering, and specifically to genetically modified methylotrophic bacteria which produce lactate. More specifically, the present invention provides a methylotrophic bacterium modified to have an increased expression of a polypeptide having lactate dehydrogenase activity. The present invention further provides a method for producing lactate using a genetically modified bacterium of the present invention.
C12N 1/32 - Procédés utilisant des alcools saturés inférieurs, c.-à-d. de C1 à C6, ou milieux de culture en contenant
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
The present invention provides the use of a protein composition comprising Methylotroph bacterial biomass or at least one fraction thereof for supplementing or substituting meat proteins in food or feed products. Also provided are food and feed ingredients, food and feed products and methods of making same.
A23K 10/16 - Ajout de micro-organismes ou de leurs produits d’extraction, p. ex. de protéines provenant d’organismes unicellulaires, à des compositions de produits alimentaires
A23K 20/147 - Dérivés polymériques, p. ex. peptides ou protéines
A23K 10/12 - Produits alimentaires pour animaux obtenus par des procédés microbiologiques ou biochimiques par fermentation de produits naturels, p. ex. d’origine végétale, de matières provenant de déchets d’origine animale ou de biomasse
A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
A23J 3/20 - Protéines à partir de micro-organismes ou à partir d'algues unicellulaires
C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
C12P 19/62 - Préparation d'O-glucosides, p. ex. glucosides avec un atome d'oxygène du radical saccharide lié directement à un hétérocycle autre que saccharide ou à un système cyclique condensé contenant un hétérocycle autre que saccharide, p. ex. coumermycine, novobiocine l'hétérocycle comportant au moins huit chaînons et uniquement l'oxygène comme hétéro-atome du cycle, p. ex. érythromycine, spiramycine, nystatine
The present invention generally relates to the field of pesticides. More specifically, the present invention relates to novel spinosyn compounds having advantageous properties, processes for their preparation, and their use as pesticides.
C07H 17/08 - Hétérocycles d'au moins huit chaînons, p. ex. érythromycines
A01N 43/22 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à plus de six chaînons
The present invention generally relates to the field of pesticides. More specifically, the present invention relates to novel spinosyn compounds having advantageous properties, processes for their preparation, and their use as pesticides.
C07H 17/08 - Hétérocycles d'au moins huit chaînons, p. ex. érythromycines
A01N 43/22 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à plus de six chaînons
The present invention generally relates to the biotechnology engineering, and specifically to genetically engineered microorganisms, e.g. of the genus Methylobacillus, which have improved properties making them particularly useful in large scale methanol fermentations. More specifically, the present invention provides a genetically engineered microorganism which is methylotrophic and can generate reducing power by methanol dissimilation, and which microorganism being modified to enable the synthesis of at least one DHAP-derived compound. The present invention further provides a method for producing a biochemical compound using a genetically modified bacterium of the present invention.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Development and planning of manufacturing processes for the
production of vitamins, food supplements for humans and
animals, bio pesticides and chemicals; biotechnological and
pharmaceutical research, consultancy related to
biotechnology, development in the field of biotechnology and
pharmacy, engineering, scientific research in the field of
genetics and genetic engineering; biological cloning
services; development and research in the field of microbial
biotechnology; research, development and testing services in
the field of biotechnology, biochemistry, microbiology and
molecular science; biological research, clinical research
and medical research; industry analysis and research;
research and development of industrial process; chemical
technological research; development of new technologies for
others; product development for others; design of production
methods; development of new strains for use in the chemical
and pharmaceutical industry and agriculture, development of
new genes, proteins and protein fractions for use in
chemistry, pharmaceuticals, agriculture, diagnostics,
medicine and industry; algorithm-supported design and
development of strains and fermentation media; testing,
authentication and quality control of molecules in the field
of microscopy; laboratory services; vaccine development and
testing; monitoring, controlling, assessing and consulting
with reference to biohazards; biological, microbiological,
pathogenic and viral screening and testing services;
proficiency testing; collecting, maintaining and providing
access to bacterial cultures and bacterial isolates for
scientific and research purposes; pharmaceutical research;
analysis and developments in the field of molecular biology;
biomedical research services; DNA sequencing for medical
research purposes; preparation of biological samples for the
analysis in research laboratories; research services in the
field of proteins, antibodies, microorganisms and cells;
development of pharmaceutical preparations, medicines,
biological molecules, stem cells, genes, vaccines, bacteria,
viruses; development of final process (downstream
processing) in the field of pharmacy, biotechnology,
genetics, biochemistry, microbiology and molecular sciences;
research services in the field of cell separation and drug
purification; scientific services related to the isolation
and cultivation of human tissues and cells; preparation of
biological samples for research purposes.
11.
MESOPHILIC, METHYLOTROPHIC BACTERIA FOR THE PH-INDEPENDENT PRODUCTION OF BIOCHEMICALS
The present invention generally relates to the biotechnology engineering, and specifically to genetically modified mesophilic, methylotrophic bacteria, which allow for the production of biochemicals in a pH-independent manner. More specifically, the present invention provides a mesophilic, methylotrophic bacterium which expresses a polypeptide which has glutamate decarboxylase (GAD) activity and is catalytically active at a pH above 5.5. The present invention further provides a mesophilic, methylotrophic bacterium which expresses a) a polypeptide having α-ketoglutarate decarboxylase (KDC) activity and b) a polypeptide having GABA transaminase (GABA-TA) activity. The present invention also provides methods for the pH-independent production of biochemicals, such as γ-amino butyric acid (GABA) or related compounds, using a bacterium of the invention.
The present invention relates to means and methods comprising a bacterial heme peroxidase and/or a functional fragment thereof for medical and non-medical use in preventing and/or controlling a pathogen on food, plants, or in or on the human or animal body. The present invention thus relates to novel medical and non-medical uses of a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants, or on the human or animal body. Furthermore, the present invention relates to corresponding methods comprising a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants or on or in the human or animal body comprising applying a sufficient amount of the bacterial heme peroxidase and/or a functional fragment thereof on said food, plants, or on mucosae, skin, in particular epidermal skin like scalp or facial skin and/or teeth to reduce the number of cells of said pathogen. In addition, the invention relates to specific heme peroxidases that have been identified to have desired properties. The invention also relates to fragments of or small heme peroxidases that have particularly advantageous properties. Moreover, the present invention further relates to corresponding compositions comprising a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants, or in or on the human or animal body. Kits comprising components used in the methods and compositions of the invention are also provided herein. Furthermore, provided is the use of a bacterial heme peroxidase and/or of a functional fragment thereof for the preparation of the compositions of the present invention. The present invention finally also relates to a method for producing a bacterial heme peroxidase protein and/or a functional fragment thereof in an engineered Bacillus subtilis strain. The inventive use of the bacterial heme peroxidase of the present invention and/or a functional fragment thereof for preventing and/or controlling a pathogen is, without being limiting, particularly useful in ecologically compatible commercial plant/crop protection campaigns as well as in daily personal care products such as toothpaste for example.
The present invention relates to means and methods comprising a bacterial heme peroxidase and/or a functional fragment thereof for medical and non-medical use in preventing and/or controlling a pathogen on food, plants, or in or on the human or animal body. The present invention thus relates to novel medical and non-medical uses of a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants, or on the human or animal body. Furthermore, the present invention relates to corresponding methods comprising a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants or on or in the human or animal body comprising applying a sufficient amount of the bacterial heme peroxidase and/or a functional fragment thereof on said food, plants, or on mucosae, skin, in particular epidermal skin like scalp or facial skin and/or teeth to reduce the number of cells of said pathogen. In addition, the invention relates to specific heme peroxidases that have been identified to have desired properties. The invention also relates to fragments of or small heme peroxidases that have particularly advantageous properties. Moreover, the present invention further relates to corresponding compositions comprising a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants, or in or on the human or animal body. Kits comprising components used in the methods and compositions of the invention are also provided herein. Furthermore, provided is the use of a bacterial heme peroxidase and/or of a functional fragment thereof for the preparation of the compositions of the present invention. The present invention finally also relates to a method for producing a bacterial heme peroxidase protein and/or a functional fragment thereof in an engineered Bacillus subtilis strain. The inventive use of the bacterial heme peroxidase of the present invention and/or a functional fragment thereof for preventing and/or controlling a pathogen is, without being limiting, particularly useful in ecologically compatible commercial plant/crop protection campaigns as well as in daily personal care products such as toothpaste for example.
A01N 59/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des éléments ou des composés inorganiques
The present invention generally relates to the biotechnology engineering, and specifically to a genetically engineered bacterium capable of producing cytokinins with isoprenoid side chains (isoprenoid cytokinins), and the preparation and application thereof.
C12P 17/16 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific and technological research and design services, namely, development and planning of manufacturing processes for the production of vitamins, food supplements for humans and animals, bio pesticides and chemicals; biotechnological and pharmaceutical research; consultancy related to biotechnology; development in the field of biotechnology and pharmaceuticals; engineering; scientific research in the field of genetics and genetic engineering; biological cloning services; development and research in the field of microbial biotechnology; scientific and technological research, development and testing services in the field of biotechnology, biochemistry, microbiology and molecular science; biological research, clinical research in the fields of genetic studies and medical research; industrial analysis of bioproducts and research in the field of bioproduction; research and development of industrial process; chemical technological research; development of new technologies for others in the field of pharmaceutical, chemical and agri-food industries; product development for others; design of production methods; custom development of new chemical and biological strains for use in the chemical, pharmaceutical, and agriculture industries; custom development of new genes, proteins and protein fractions for use in chemistry, pharmaceuticals, agriculture, diagnostics, medicine and industry; algorithm-supported custom design and development of chemical and biological strains and fermentation media; testing, authentication and quality control of molecules for others in the field of microscopy; biological research laboratory services; vaccine development and testing; monitoring, controlling, assessing and consulting with reference to biohazards for scientific research purposes; biological, microbiological, pathogenic and viral screening and testing services for scientific research purposes; collecting, maintaining and providing access to bacterial cultures and bacterial isolates for scientific and research purposes; pharmaceutical research; analysis and developments in the field of molecular biology for scientific research purposes; biomedical research services; DNA sequencing for medical research purposes; scientific laboratory services, namely, preparation of biological samples for analysis in research laboratories; research services in the field of proteins, antibodies, microorganisms and cells; development of pharmaceutical preparations, medicines, biological molecules, stem cells, genes, vaccines, bacteria, viruses; scientific and technological research and design services, namely, development of final downstream processing in the production of microbial production strains in the field of pharmacy, biotechnology, genetics, biochemistry, microbiology and molecular sciences; research services in the field of cell separation and pharmaceutical drug purification; scientific laboratory services related to the isolation and cultivation of human tissues and cells; scientific laboratory services, namely, preparation of biological samples for research purposes.
16.
GENETICALLY MODIFIED METHYLOBACILLUS BACTERIA HAVING IMPROVING PROPERTIES
The present invention generally relates to the biotechnology engineering, and specifically to genetically modified bacteria of the genus Methylobacillus which have improved properties making them particularly useful in large scale methanol fermentations. More specifically, the present invention provides a bacterium of the genus Methylobacillus which has been modified to have a decreased production of exopolysaccharides (EPS) compared to an otherwise identical bacterium that does not carry said modification. The present invention further provides a method for producing a biochemical compound using a genetically modified bacterium of the present invention.
The present invention generally relates to the biotechnology engineering, and specifically to genetically modified methylotrophic bacteria which produce lactate. More specifically, the present invention provides a methylotrophic bacterium modified to have an increased expression of a polypeptide having lactate dehydrogenase activity. The present invention further provides a method for producing lactate using a genetically modified bacterium of the present invention.
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
A01N 63/20 - BactériesSubstances produites par des bactéries ou obtenues à partir de celles-ci
A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
A01N 25/30 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles caractérisés par les agents tensio-actifs
The present invention generally relates to the biotechnology engineering, and specifically to genetically modified bacteria of the genus Methylobacillus which have improved properties making them particularly useful in large scale methanol fermentations. More specifically, the present invention provides a bacterium of the genus Methylobacillus which has been modified to have a decreased production of exopolysaccharides (EPS) compared to an otherwise identical bacterium that does not carry said modification. The present invention further provides a method for producing a biochemical compound using a genetically modified bacterium of the present invention.
MethylobacillusMethylobacillusMethylobacillus which has been modified to have a decreased production of exopolysaccharides (EPS) compared to an otherwise identical bacterium that does not carry said modification. The present invention further provides a method for producing a biochemical compound using a genetically modified bacterium of the present invention.
The present invention generally relates to the field of pesticides. More specifically, the present invention relates to novel spinosyn compounds having advantageous properties, processes for their preparation, and their use as pesticides.
C07H 17/08 - Hétérocycles d'au moins huit chaînons, p. ex. érythromycines
A01N 43/22 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à plus de six chaînons
The present invention generally relates to the field of pesticides. More specifically, the present invention relates to novel spinosyn compounds having advantageous properties, processes for their preparation, and their use as pesticides.
C07H 17/08 - Hétérocycles d'au moins huit chaînons, p. ex. érythromycines
A01N 43/22 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à plus de six chaînons
23.
GENETICALLY ENGINEERED BACTERIUM CAPABLE OF PRODUCING CYTOKININS WITH ISOPRENOID SIDE CHAINS
The present invention generally relates to the biotechnology engineering, and specifically to a genetically engineered bacterium capable of producing cytokinins with isoprenoid side chains (isoprenoid cytokinins), and the preparation and application thereof.
The present invention generally relates to the biotechnology engineering, and specifically to a genetically engineered bacterium capable of producing cytokinins with isoprenoid side chains (isoprenoid cytokinins), and the preparation and application thereof.
The present invention generally relates to the biotechnology engineering, and specifically to genetically modified bacteria of the genus Methylobacillus which have improved properties making them particularly useful in large scale methanol fermentations. More specifically, the present invention provides a bacterium of the genus Methylobacillus which has been modified to have a decreased production of exopolysaccharides (EPS) compared to an otherwise identical bacterium that does not carry said modification. The present invention further provides a method for producing a biochemical compound using a genetically modified bacterium of the present invention.
C07K 14/34 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Corynebacterium (G)
C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C12N 15/31 - Gènes codant pour des protéines microbiennes, p. ex. entérotoxines
C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora
C12P 1/04 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des bactéries
26.
METHYLOBACILLUS BACTERIA HAVING IMPROVING PROPERTIES
The present invention generally relates to the biotechnology engineering, and specifically to genetically modified bacteria of the genus Methylobacillus which have improved properties making them particularly useful in large scale methanol fermentations. More specifically, the present invention provides a bacterium of the genus Methylobacillus which has been modified to have a decreased production of exopolysaccharides (EPS) compared to an otherwise identical bacterium that does not carry said modification. The present invention further provides a method for producing a biochemical compound using a genetically modified bacterium of the present invention.
C07K 14/34 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Corynebacterium (G)
C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
C12P 1/04 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des bactéries
27.
MESOPHILIC, METHYLOTROPHIC BACTERIA FOR THE PH-INDEPENDENT PRODUCTION OF BIOCHEMICALS
The present invention generally relates to the biotechnology engineering, and specifically to genetically modified mesophilic, methylotrophic bacteria, which allow for the production of biochemicals in a pH-independent manner. More specifically, the present invention provides a mesophilic, methylotrophic bacterium which expresses a polypeptide which has glutamate decarboxylase (GAD) activity and is catalytically active at a pH above 5.5. The present invention further provides a mesophilic, methylotrophic bacterium which expresses a) a polypeptide having α-ketoglutarate decarboxylase (KDC) activity and b) a polypeptide having GABA transaminase (GABA-TA) activity. The present invention also provides methods for the pH-independent production of biochemicals, such as γ-amino butyric acid (GABA) or related compounds, using a bacterium of the invention.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific and technological services and research and
design relating thereto; industrial analysis, industrial
research and industrial design services; quality control and
authentication services; design and development of computer
hardware and software; research, development and testing
services in the fields of biotechnology, biochemistry,
microbiology and molecular science; biological research,
clinical research and medical research; industrial analysis
and research; research and development of industrial
processes; chemical technological research; development of
new technologies for others; product development for others;
design of production methods.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific and technological services, namely, scientific research in the field of microbial biotechnology and scientific and technological research and design in the field of microbial biotechnology; industrial microbial biotechnological research and analysis, industrial research in the field of microbial biotechnology and industrial design services; quality control of final products and authentication services in the field of microbial biotechnology; design and development of computer hardware and software; research, development and testing services in the fields of biotechnology, biochemistry, microbiology and molecular science; biological research, clinical research in the field of developing active substances and medical research; industrial analysis of microorganisms and research in the field of microbial biotechnology; research and development of industrial processes in the field of microbial biotechnology; chemical technological research; development of new technologies for others in the field of microbial biotechnology; product development for others; design of production methods, namely, development and optimization of analytical methods
30.
GENE CLUSTER FOR THE BIOSYNTHETIC PRODUCTION OF TETRACYCLINE COMPOUNDS IN A HETEROLOGOUS HOST
HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH (Allemagne)
ACIES BIO D.O.O. (Slovénie)
Inventeur(s)
Müller, Rolf
Lukežic, Tadeja
Remškar, Maja
Zaburannyi, Nestor
Bader, Chantal
Sikandar, Asfandyar
Köhnke, Jesko
Abrégé
The present invention relates to the application of biosynthetic engineering for the heterologous expression of a gene cluster for the biosynthesis of tetracycline compounds, notably chelocardin and its analogues. More particularly, the present invention p ertains to a gene cluster encoding polypeptides involved in tetracycline biosynthesis, which gene cluster is suitable for heterologous expression of the biosynthetic pathway in a host cell. The present invention further pertains to DNA construct s comprising the gene cluster, to recombinant heterologous host cell s comprising the gene cluster or the DNA construct, to p rocess es for the biosynthetic production of a tetracycline compound employing such recombinant host cells, and to tetracycline compou nd s thereby produced. The present invention also pertains to fusion proteins which are useful in the production of tetracycline compounds.
C07C 225/20 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones ayant des groupes amino liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons du squelette carboné
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
C07K 14/36 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant d'ActinomycesPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Streptomyces (G)
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
31.
COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES CHARACTERIZED BY INSUFFICIENT PANTOTHENATE KINASE ACTIVITY
Methods and pharmaceutical compositions for use in treating diseases associated with insufficient activity of the pantothenate kinase enzyme (e.g., CASTOR diseases) are disclosed. The methods and compositions involve an effective amount of an active derivative of 4'-phosphopantetheine.
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61K 31/661 - Acides du phosphore ou leurs esters n'ayant pas de liaison P-C, p. ex. fosfosal, dichlorvos, malathion
The invention relates to the use of phosphopantetheine compounds alone and in combination with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. Preferred medical uses relate to the treatment or prevention of dyslipidemia.
The invention provides a fungal cell, such as a yeast cell, capable of growing in co- cultivation with Propionihacterium. Also provided arc methods of producing such cells and fermentation processes using the fungal cell of the invention and Propionihacterium in co-cultivation. Such co-cultivation significantly reduces the chemical oxygen demand load of the waste fermentation broth.
C12P 1/02 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des champignons
C12P 1/04 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des bactéries
The invention provides a fungal cell, such as a yeast cell, capable of growing in co- cultivation with Propionihacterium. Also provided arc methods of producing such cells and fermentation processes using the fungal cell of the invention and Propionihacterium in co-cultivation. Such co-cultivation significantly reduces the chemical oxygen demand load of the waste fermentation broth.
STABLE PANTETHEINE DERIVATIVES FOR THE TREATMENT OF PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION (PKAN) AND METHODS FOR THE SYNTHESIS OF SUCH COMPOUNDS
The invention relates to (S)-acyl-4'-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment of neurodegenerative diseases, such as PKAN.
A61K 31/661 - Acides du phosphore ou leurs esters n'ayant pas de liaison P-C, p. ex. fosfosal, dichlorvos, malathion
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
37.
NOVEL POLYKETIDE COMPOUNDS AND METHODS OF MAKING SAME
The present invention relates to novel polyketide compounds and to enzymes and production organisms for obtaining such novel polyketide compounds. Polyketides of the present invention include non-natural, chemically active extender units, which are incorporated into the polyketide molecule by virtue of promiscuous acyl transferase domains of the polyketide synthase enzyme. Such polyketides including chemically active side chains can easily be chemically modified to yield novel polyketide drugs or drug candidates.
C07D 407/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C12P 19/62 - Préparation d'O-glucosides, p. ex. glucosides avec un atome d'oxygène du radical saccharide lié directement à un hétérocycle autre que saccharide ou à un système cyclique condensé contenant un hétérocycle autre que saccharide, p. ex. coumermycine, novobiocine l'hétérocycle comportant au moins huit chaînons et uniquement l'oxygène comme hétéro-atome du cycle, p. ex. érythromycine, spiramycine, nystatine
C12P 17/18 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, p. ex. rifamycine
