A system for NMR/MRI, having X, Y, Z directions, includes an RF coil having a B0 static magnetic field in the Z direction and a transverse B1 RF magnetic field in the XY directions. Currents in the RF coil are distributed so that the transverse B1 field is substantially uniform in the XY plane.
A method for shaping an RF pulse for use with an MRI system includes shaping an RF pulse for use with an MRI system that uses an RF coil. The RF pulse is shaped to reduce changes in B1 amplitude and in an off-resonance effect with respect to Larmor frequency as a function of distance from the RF coil.
Medical imaging apparatus, namely, apparatus for tissue
imaging; medical imaging apparatus incorporating
downloadable or recorded medical imaging software for tissue
imaging; medical imaging apparatus for use in surgical
procedures, namely, apparatus for tissue imaging for
diagnosis and treatment of cancer; magnetic resonance
imaging apparatus for medical purposes, namely, for tissue
imaging; medical imaging apparatus for real-time
intra-operative tissue imaging; none of the foregoing for
use in performing ophthalmic surgery.
Medical imaging apparatus, namely, apparatus for tissue
imaging; medical imaging apparatus for real-time
intra-operative imaging of excised tissue; medical imaging
system for tissue imaging comprising a compact, cart-mounted
mobile imaging device and disposable specimen trays for
holding body tissue samples for testing purposes; medical
specimen tissue containers for use with medical imaging
apparatus.
6.
OPTIMALLY-SHAPED RF PULSE FOR MRI APPLICATIONS IN THE PRESENCE OF B0 AND B1 INHOMOGENEITIES
A method for shaping an RF pulse for use with an MRI system includes shaping an RF pulse for use with an MRI system that uses an RF coil. The RF pulse is shaped to reduce changes in B1 amplitude and in an off-resonance effect with respect to Larmor frequency as a function of distance from the RF coil.
G01R 33/483 - Systèmes d'imagerie RMN avec sélection de signaux ou de spectres de régions particulières du volume, p. ex. spectroscopie in vivo
G01R 33/44 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique utilisant la résonance magnétique nucléaire [RMN]
7.
METHOD FOR EXTRACTING MULTIPLE T2* VALUES FROM SINGLE SET OF CPMG DATA
A method for extracting multiple T2* values from a single set of CPMG data includes using an MRI system that includes an RF coil to image tissue and generate NMR time domain signals via a CPMG sequence, converting the signals to a set of spectra, one spectrum per echo, by performing a Fourier transform of complex time domain signals associated with the signals, and dividing each of the spectra into a number of segments and calculating a T2* value for each segment. The T2* values represent decay rates as a function of distance from the RF coil.
G01R 33/44 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique utilisant la résonance magnétique nucléaire [RMN]
G01R 33/561 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne par réduction du temps de balayage, c.-à-d. systèmes d'acquisition rapide, p. ex. utilisant des séquences d'impulsions écho-planar
A system includes an NMR system (10) including a coil (18) and a magnet (12) capable of obtaining NMR information from a tissue (17) and an MRI processor (19) for creating a pixel map of the tissue (17) from the NMR information. The system also includes an OCT system (20) with an OCT processor (21) capable of creating an optical coherence tomography of the tissue (17). A tissue sample holder (16) is coupled to a manipulator to move the tissue sample holder (16) to the NMR system (10) for creating the pixel map of the tissue (17) and to move the tissue sample holder (16) to the OCT system (20) for creating the optical coherence tomography of the tissue (17).
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c.-à-d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
G01R 33/56 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
Medical imaging apparatus, namely, apparatus for tissue imaging; Medical imaging apparatus incorporating downloadable or recorded medical imaging software for tissue imaging; Medical imaging apparatus for use in surgical procedures, namely, apparatus for tissue imaging for diagnosis and treatment of cancer; Magnetic resonance imaging apparatus for medical purposes, namely, for tissue imaging; Medical imaging apparatus for real-time intra-operative tissue imaging; none of the foregoing for use in performing ophthalmic surgery
A marking system (10) includes a tissue holder (14) which has a cover (16). An inner surface of the cover (16) is coated with a donor layer (18). A pulsed laser (20) emits a laser pulse sufficient to transfer material from the donor layer (18) onto tissue (12) held in the tissue holder (14) by means of a laser-induced forward transfer (LIFT) technique, and the material transferred to the tissue (12) creates a mark on the tissue (12).
C23C 14/04 - Revêtement de parties déterminées de la surface, p. ex. au moyen de masques
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 1/28 - Préparation d'échantillons pour l'analyse
A system includes an NMR system (10) including a coil (18) and a magnet (12) capable of obtaining NMR information from a tissue (17) and an MRI processor (19) for creating a pixel map of the tissue (17) from the NMR information. The system also includes an OCT system (20) with an OCT processor (21) capable of creating an optical coherence tomography of the tissue (17). A tissue sample holder (16) is coupled to a manipulator to move the tissue sample holder (16) to the NMR system (10) for creating the pixel map of the tissue (17) and to move the tissue sample holder (16) to the OCT system (20) for creating the optical coherence tomography of the tissue (17).
G01R 33/30 - Dispositions pour le traitement des échantillons, p. ex. cellules d'essai, mécanismes rotationnels
G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
G01R 33/44 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique utilisant la résonance magnétique nucléaire [RMN]
G01R 33/465 - Spectroscopie RMN appliquée à du matériau biologique, p. ex. tests in vitro
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
A tissue imaging system (10) includes a stationary array of magnets (12) arranged to generate an inhomogeneous main magnetic field (B0), a tissue holder (16) adjacent the array of magnets (12) and operative to move tissue (14) placed therein about and/or along a coordinate axis, one or more RF receive coils (20) adjacent the tissue holder (16) and the magnets (12), and an MRI processor in communication with the magnets (12), the RF receive coils (20) and the tissue holder (16). An image of the tissue (14) is created by using spatial encoding of magnetic resonance signals generated by the magnets (12) and RF receive coils (20) for different spatial orientations of the tissue (14) moved by the tissue holder (16) with respect to the magnets. Spatial inhomogeneities in the main magnetic field spatially modulate a phase of each of the magnetic resonance signals.
G01R 33/383 - Systèmes pour produire, homogénéiser ou stabiliser le champ magnétique directeur ou le champ magnétique à gradient utilisant des aimants permanents
G01R 33/30 - Dispositions pour le traitement des échantillons, p. ex. cellules d'essai, mécanismes rotationnels
G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
A system and method are described for ex-vivo, real-time NMR analysis of tissue removed either for purposes of biopsy or tissue removed during an ablation procedure.
A tissue imaging system (10) includes a stationary array of magnets (12) arranged to generate an inhomogeneous main magnetic field (B0), a tissue holder (16) adjacent the array of magnets (12) and operative to move tissue (14) placed therein about and/or along a coordinate axis, one or more RF receive coils (20) adjacent the tissue holder (16) and the magnets (12), and an MRI processor in communication with the magnets (12), the RF receive coils (20) and the tissue holder (16). An image of the tissue (14) is created by using spatial encoding of magnetic resonance signals generated by the magnets (12) and RF receive coils (20) for different spatial orientations of the tissue (14) moved by the tissue holder (16) with respect to the magnets. Spatial inhomogeneities in the main magnetic field spatially modulate a phase of each of the magnetic resonance signals.
G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
G01R 33/30 - Dispositions pour le traitement des échantillons, p. ex. cellules d'essai, mécanismes rotationnels
G01R 33/383 - Systèmes pour produire, homogénéiser ou stabiliser le champ magnétique directeur ou le champ magnétique à gradient utilisant des aimants permanents
An imaging system includes a sample holder (2) for holding a sample of tissue (1), and a motion actuator upon which the sample holder is placed. The actuator moves the sample in at least translational motion in an x/y plane. An imaging detector (16) is smaller in size than the sample and forms images of a portion of the sample, the portion being smaller than the entire sample. The actuator moves the sample with respect to the imaging detector until the entire sample is imaged.
G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
G01N 23/04 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux
16.
MRI system for margin assessment of ex-vivo sample
A system for margin assessment of an ex-vivo tissue (25) is provided, including a magnetic resonance imaging (MRI) scanner (14) controlled by a control unit (12), and a tissue container (24) for holding a sample of an ex-vivo tissue (25). The MRI scanner (14) includes a coil-magnet assembly (31) including magnets (34), wherein the tissue (25), placed in the container (24), is placed under a constant static magnetic field (Bo), which is induced by the magnets (34), and the container (24) is positioned so the sensitive region is within a measured field of view (FOV) excited by one or more transmit/receive coils (38) operative to generate a time-varying RF B1 electro-magnetic field pointing towards the tissue (25), and wherein the container (24) is fixed on a moving table (40).
G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
G01R 33/30 - Dispositions pour le traitement des échantillons, p. ex. cellules d'essai, mécanismes rotationnels
G01R 33/483 - Systèmes d'imagerie RMN avec sélection de signaux ou de spectres de régions particulières du volume, p. ex. spectroscopie in vivo
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
G01R 33/341 - Détails de structure, p. ex. résonateurs comprenant des bobines de surface
G01R 33/3415 - Détails de structure, p. ex. résonateurs comprenant des bobines de surface comprenant des ensembles de bobines
G01R 33/381 - Systèmes pour produire, homogénéiser ou stabiliser le champ magnétique directeur ou le champ magnétique à gradient utilisant des électro-aimants
G01R 33/383 - Systèmes pour produire, homogénéiser ou stabiliser le champ magnétique directeur ou le champ magnétique à gradient utilisant des aimants permanents
17.
TISSUE SAMPLE HOLDER FOR DIFFERENT IMAGING SYSTEMS
A tissue sample holder (10) includes a plurality of chambers (12) separated from each other by partitions (14). The chambers (12) are configured to receive therein tissue samples (4) at predefined locations. A biopsy holder (1) includes a plurality of biopsy chambers (3). Each of the chambers (12) of the tissue sample holder (10) is configured to receive one of the biopsy chambers (3). A cover (16) has an open position which allows tissue samples (4) to be inserted in the chambers (12) and a closed position in which an underside of the cover (16) closes against the tissue samples (4). The tissue sample holder (10), the cover (16) and the biopsy holder (1) are made of a material that allows imaging of the tissue samples (4) in the closed position.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
G01N 1/36 - Enrobage ou montage analogue d'échantillons
18.
MRI SYSTEM FOR MARGIN ASSESSMENT OF EX-VIVO SAMPLE
A system for margin assessment of an ex-vivo tissue (25) is provided, including a magnetic resonance imaging (MRI) scanner (14) controlled by a control unit (12), and a tissue container (24) for holding a sample of an ex-vivo tissue (25). The MRI scanner (14) includes a coil-magnet assembly (31) including magnets (34), wherein the tissue (25), placed in the container (24), is placed under a constant static magnetic field (Bo), which is induced by the magnets (34), and the container (24) is positioned so the sensitive region is within a measured field of view (FOV) excited by one or more transmit/receive coils (38) operative to generate a time-varying RF B1 electro-magnetic field pointing towards the tissue (25), and wherein the container (24) is fixed on a moving table (40).
G01R 33/30 - Dispositions pour le traitement des échantillons, p. ex. cellules d'essai, mécanismes rotationnels
G01R 33/483 - Systèmes d'imagerie RMN avec sélection de signaux ou de spectres de régions particulières du volume, p. ex. spectroscopie in vivo
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
A system (10) for margin assessment of an ex-vivo tissue (18), including an imaging scanner (12) controlled by an imaging control unit (14), and an ex-vivo sample holder (16) for holding a sample of an excised tissue (18), the sample holder (16) being sized such that excised lump edges (24) of the excised tissue (18) are forced against a surface of the sample holder (16) such that the edges (24) change shape to have a predetermined geometry, and wherein the imaging scanner (12) is positioned relative to the sample holder (16) such that the imaging scanner (12) acquires images not of all the tissue (18) but rather of the edges (24) that have the predetermined geometry and which are in a sensitive region (40) extending into a peripheral margin of the tissue (18).
G01R 33/483 - Systèmes d'imagerie RMN avec sélection de signaux ou de spectres de régions particulières du volume, p. ex. spectroscopie in vivo
G01R 33/30 - Dispositions pour le traitement des échantillons, p. ex. cellules d'essai, mécanismes rotationnels
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
G01R 33/341 - Détails de structure, p. ex. résonateurs comprenant des bobines de surface
G01R 33/3415 - Détails de structure, p. ex. résonateurs comprenant des bobines de surface comprenant des ensembles de bobines
A system (10) for tumor margin assessment of an ex-vivo tissue (18), including an imaging scanner (e.g. an MRI scanner) (12) controlled by an imaging control unit (14), and an ex-vivo sample holder (16) for holding a sample of an excised tissue (18), the sample holder (16) being sized such that excised lump edges (24) of the excised tissue (18) are forced against a surface of the sample holder (16) such that the edges (24) change shape to have a predetermined geometry, and wherein the imaging scanner (12) is positioned relative to the sample holder (16) such that the imaging scanner (12) acquires images not of all the tissue (18) but rather of the edges (24) that have the predetermined geometry and which are in a sensitive region (40) extending into a peripheral margin of the tissue (18).
G01R 33/30 - Dispositions pour le traitement des échantillons, p. ex. cellules d'essai, mécanismes rotationnels
G01R 33/483 - Systèmes d'imagerie RMN avec sélection de signaux ou de spectres de régions particulières du volume, p. ex. spectroscopie in vivo
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
