A method for operating a clarification setup of a bioprocess installation, which clarification setup comprises a fluidized bed centrifuge and a pumping arrangement, wherein the fluidized bed centrifuge comprises at least one centrifuge chamber turned around a geometrical centrifuge axis, wherein the bioprocess installation comprises an electronic process control for controlling the fluidized bed centrifuge and pumping arrangement, wherein the fluidized bed centrifuge is being operated in a forward operation for a particle loading cycle and/or a particle washing cycle and in a backward operation for a particle discharging cycle, wherein in case where a particle loading cycle is provided, cell broth loaded into the centrifuge chamber proceeds to form a growing particle accumulation in the centrifuge chamber, wherein the clarification setup comprises a monitoring sensor arrangement with at least one optical sensor for producing monitoring sensor data, which are being transmitted to the electronic process control.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
A method for operating a clarification setup, wherein the clarification setup comprises a fluidized bed centrifuge, wherein the fluidized bed centrifuge comprises at least two centrifuge chambers, wherein the fluidized bed centrifuge is being operated in a forward operation for a particle loading cycle and/or a particle washing cycle and in a backward operation for a particle discharging cycle wherein the clarification setup comprises a monitoring sensor arrangement with at least one sensor for producing monitoring sensor data, which are being transmitted to the electronic process control. In a monitoring routine, monitoring sensor data are being produced individually by the monitoring sensor arrangement and that during the loading cycle, in an adjusting routine, at least one parameter of the clarification setup is being adjusted based on the monitoring sensor data as to control the loading of the cell broth the centrifuge chambers individually according to a predefined adjusting strategy.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
A method of controlling a biopharmaceutical purification process, preferably a continuous process, making use of a separation arrangement. The separation arrangement preferably includes multiple chromatography columns or filtration devices. The method comprises the following steps: repeatedly acquiring an absorption spectrum inline or online at a fluid stream with a detector which is capable of recording spectra within a wavelength range between 190 nm and 2400 nm, preferably between 190 nm and 390 nm or 190 nm and 780 nm or 1100 nm and 2400 nm; real-time processing of the acquired spectrum; and real- time monitoring and controlling the process based on the processed spectrum. The step of processing includes at least one of the following measures: reducing noise; reducing spectral interference; correcting the acquired spectrum for scattering effects and/or other background effects.
G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
4.
ON-LINE BIOMOLECULAR ANALYSIS FOR MONITORING OR CONTROLLING BIOPROCESSES
The disclosure relates to monitoring or controlling bioprocesses by way of withdrawing discrete fluid samples from a reactor and performing on-line analysis of said sample using a fluidic manifold, for example, by way of a sensor based on label-free biomolecular interaction analysis. The disclosure relates to a system for measuring one or more analytes in discrete fluid samples from a vessel adapted to contain a fluid having one or more sensors for the measurement of the analytes in a contact volume of the fluid sample. An analysis module having at least one main sampling line in fluidic connection with the vessel and one or more pumps in fluidic connection with said main sampling line(s) and adapted to selectively pump fluid from in the main sampling line away from the vessel. At least one fluid distribution tubing in fluidic connection with the analysis module. A manifold has a body.
C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
5.
METHOD AND DEVICE FOR AUTOMATING THE FOAM CONTROL IN A BIOREACTOR
The invention relates to a method for automating the foam regulation during a bioprocess for cultivating cells in a bioreactor, said method comprising the following steps: determining values of one or more process variables of the bioprocess which is/are relevant for the formation of foam in the bioreactor; transferring the determined values as input signals to a controller; generating, by the controller, output signals for at least one foam regulation device depending on the input signals; and controlling the at least one foam regulation device in a requirements-oriented manner by means of the output signals output by the controller.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
6.
COUPLING DEVICE FOR COUPLING TO A DIAPHRAGM DEVICE, DIAPHRAGM DEVICE AND METHOD
A coupling device (1) for coupling to a flexible diaphragm (51) of a diaphragm device (50) and comprising a base structure (10) for attaching the diaphragm device (50) thereto; an actuator structure (20) mounted movable along an actuation direction (A) relative to the base structure (10) and having a diaphragm grasping element (22) pivotably mounted between a release position and a grasping position for coupling the actuator structure (20) to the flexible diaphragm (51) in the grasping position; and a fixation structure (30) mounted movable along a fixation direction (F) relative to the base structure (10) between an open position and a closed position and designed to fix in the closed position the diaphragm grasping element (22) against leaving the grasping position.
F16K 1/48 - Fixation des corps de soupapes aux tiges des soupapes
F16K 7/16 - Dispositifs d'obturation à diaphragme, p. ex. dont un élément est déformé, sans être déplacé entièrement, pour fermer l'ouverture à diaphragme plat, en forme d'assiette ou en forme de bol disposé pour être déformé contre un siège plat le diaphragme étant actionné mécaniquement, p. ex. par une tige filetée ou par came
F16L 37/127 - Accouplements du type à action rapide dans lesquels l'assemblage entre les extrémités s'aboutant ou se chevauchant est maintenu par des organes de blocage utilisant des crochets, cliquet, ou autres organes de blocage mobiles ou que l'on peut insérer utilisant des crochets articulés autour d'un axe
7.
System for Simultaneous Distribution of Fluid to Multiple Vessels and Method of Using the Same
A fluid distribution system includes an input tube, a plurality of vessels, and a distribution hub. The input tube is configured to extend from a supply vessel. Each vessel of the plurality of vessels includes an inflow conduit. The distribution hub includes a single inlet and a plurality of outlets. The single inlet is defined in a bottom of the distribution hub and is in fluid communication with the input tube such that the distribution hub is configured to receive fluid from the input tube through the single inlet. Each outlet of the plurality of outlets is in fluid communication with the single inlet and in fluid communication with a respective inflow conduit such that the distribution hub is configured to provide an equal portion of the fluid received through the single inlet to each of the inflow conduits.
B67D 7/02 - Appareils ou dispositifs pour transférer des liquides à partir de récipients ou de réservoirs de stockage en vrac vers des véhicules ou des récipients portables, p. ex. pour la vente au détail pour transférer des liquides autres que des carburants ou des lubrifiants
B67D 7/38 - Aménagements des tuyaux flexibles, p. ex. de la liaison de pilotage d'une moto-pompe
A membrane for microbiological analysis, a production method of a membrane for microbiological analysis, and the use of such membranes for microbiological analysis. Examples include a cellulose membrane for microbiological analysis that is impregnated with a non-ionic surfactant in an amount of from 100 ng/cm2 to 1.0 mg/cm2, with the membrane having a nominal pore size of from 0.20 μm to 0.80 μm, and a cumulative adsorption pore volume of less than 0.010 cm3/g.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
A composite article includes a lattice and an elastomeric section. The lattice includes a plurality of members that form an open-mesh frame defining a plurality of voids between the adjacent members of the frame. The elastomeric section is formed of an elastomer that is disposed about the lattice and within the voids of the lattice. The composite article may be a circular gasket, a gasket with a grip, a rectangular gasket, a vessel cap, a flask stand, and a handle for a hand tool.
B65D 41/00 - Capuchons, p. ex. couvercles à rebords ou capsules à sertissage, c.-à-d. éléments ayant des parties prenant sur la périphérie extérieure d'un col ou d'une paroi limitant une ouverture de versement ou de déchargeCouvercles de protection en forme de capuchons pour les éléments de fermeture, p. ex. couvercles décoratifs en feuille de métal ou en papier
B01L 9/00 - Dispositifs de supportDispositifs de serrage
B25G 1/10 - Fabrication des manches caractérisés par le matériau ou la forme
B29C 45/14 - Moulage par injection, c.-à-d. en forçant un volume déterminé de matière à mouler par une buse d'injection dans un moule ferméAppareils à cet effet en incorporant des parties ou des couches préformées, p. ex. moulage par injection autour d'inserts ou sur des objets à recouvrir
B33Y 80/00 - Produits obtenus par fabrication additive
F16J 15/02 - Joints d'étanchéité entre surfaces immobiles entre elles
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
17 - Produits en caoutchouc ou en matières plastiques; matières à calfeutrer et à isoler
Produits et services
Filter modules, namely filter capsules, filter candles,
filter cassettes, coil modules, filter coils, filter coils
in connection with filter centrifuges, band filters, small
filters, small filters in connection with centrifuge tubes
and as centrifugal concentrators, disposable filters;
membrane filters and filter matting being parts of machines,
for use in biotechnology, environmental protection, for the
drinks, food, luxury items, pharmaceutical, cosmetics,
electronics and general chemical industries, and for use in
genetic engineering, medicine and in laboratories, and for
treatment and analysis of water and effluent; filters being
parts of machines; membrane filters for use as part of
machines. Laboratory filters; filtering units for laboratory use;
liquid filter units, namely, filter cartridges, plastic
hoses and hose connectors sold as a set for laboratory use;
membranes for filtration (laboratory use); filters for use
with laboratory chromatography apparatus; membrane filters
and filter matting for laboratories with adsorption
properties, membrane adsorbers, namely adsorption membranes,
ion exchange membranes, ligand membranes and activated
membranes in the form of hollow fibre membranes, tube
membranes and flat membranes as strips or cut to size for
use in apparatus, filters and filter modules for the
aforesaid fields of application; membrane filters and filter
matting as parts of microtitre plates; membrane filters and
filter matting as parts of diagnostic tests such as
diagnostic assays and immunoassays; membrane filters and
filter matting as parts of filter systems or as independent
filters for chromatographic analyses and chemical
separation, reconcentration, for sterilisation and
ultrapurification of fluids; filters and filter modules for
filtering and reconcentration of biological solutions,
namely of viral and bacterial suspensions; filters and
filter modules for treating blood and other bodily fluids. Air filters and filtering units, for industrial use; liquid
filters and filtering units, for industrial use; filters for
filtering fluids, filter modules, filter candles and filter
capsules; liquid filter units, namely, filter cartridges,
plastic hoses and hose connectors, sold as a set, for
industrial installations; filters for water filtering
apparatus; cartridge filtration units [water treatment
equipment]; filters for use with industrial chromatography
apparatus; apparatus for water treatment and for preparing
solutions in the pharmaceutical, medical and laboratory
fields; equipment for de-ionising water; equipment for
de-pyrogenisation of solutions and for separating harmful
substances from fluids; filters and filter modules for
desalination of protein solutions and other biological
media; filters and filter modules for analysis and
separation of ions, macromolecules and biomolecules, namely
carbohydrates, peptides, proteins and nucleic acids and for
separating heavy metals and harmful substances from fluids;
filters for industrial use, namely, membrane filters and
filter matting having applications in biotechnology,
environmental protection, the drinks, food, luxury items,
pharmaceutical, cosmetics, electronics and general chemical
industries, and in genetic engineering, medicine and
laboratories, and the treatment and analysis of water and
effluents. Membranes and semi-processed synthetic filtering materials;
polymeric membranes; polymeric porous membranes in hollow
fibre form; polymeric porous membranes in sheet form;
transfer membranes of cellulose derivatives; transfer
membranes of cellulose; transfer membranes of polyamides;
transfer membranes of polyvinylidene fluoride; cross-linked
polymeric membranes in sheet form; cross-linked polymeric
membranes in hollow fibre form.
11.
METHOD FOR PERFORMING A TANGENTIAL FLOW FILTRATION ON A BIOMOLECULAR SOLUTION
The invention relates to a method for performing a tangential flow filtration on a biomolecular solution, in particular for performing a single pass tangential flow filtration on a biomolecular solution, as part of a production process for biomolecules, wherein a tangential flow filtration arrangement (1) is provided, wherein the tangential flow filtration arrangement (1) comprises a tangential flow filtration module (2), wherein the tangential flow filtration is performed inside the tangential flow filtration module (2), wherein the tangential flow filtration module (2) comprises a filter (3), a feed input fluid line (4) for the biomolecular solution as a feed medium, a retentate output fluid line (6) for a retentate, a filtrate output fluid line (7) for a filtrate, and preferably a buffer input fluid line (5) for a buffer, wherein the tangential flow filtration arrangement (1) comprises at least two actuators (8) influencing the tangential flow filtration, wherein the tangential flow filtration arrangement (1) comprises a control module (10), wherein the control module (10) controls the tangential flow filtration by providing control signals to the actuators (8) and measuring at least two measured variables (11) describing the tangential flow filtration, wherein the control module (10) uses a process control to control the tangential flow filtration. It is proposed that the process control is a model predictive control (13), that the control module (10) inputs the measured variables (11) as input variables (14) into the model and derives at least two manipulated variables (15) as control signals for the actuators (8).
The invention relates to a device for continuous virus inactivation during a protein production process, in particular an antibody production process, wherein the device comprises an axially extending hollow-body holder (1) for holding an elongated, elastically deformable hollow body (2), in particular a flexible tube, wherein the device comprises at least two axially extending rollers (3, 4), in particular three or four rollers (3, 4, 5, 6), each of which, when the device has been assembled as intended, squeezes the hollow body (2) and thereby divides the internal volume (7) of the hollow body (2) into volume portions (8) fluidically separated from one another, wherein the continuous virus inactivation is carried out in the volume portions (8) of the hollow body (2). It is proposed that the device comprises a support element (9) which, when the device has been assembled as intended, supports the lateral faces of each of the rollers (3, 4, 5, 6) in at least one point.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
B01D 15/24 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au traitement des fractions à répartir
13.
METHOD OF OPERATING A BIOPROCESSING ARRANGEMENT COMPRISING A CLARIFICATION SET-UP TO REMOVE CELL DEBRIS FROM A CELL BROTH
The invention relates to a method of operating a bioprocessing arrangement (1) comprising a clarification set-up (2) to remove cell debris from a cell broth (10), wherein the clarification set-up (2) comprises a fluidized bed centrifuge (8) with at least one centrifuge chamber (11), wherein the cell broth (10) is separated into at least a waste fraction (12) and an output fraction (13), wherein the separation of the cell broth (10) into the waste fraction (12) and the output fraction (13) comprises a loading step (14) during which the centrifuge chamber (11) is loaded with cells of the cell broth (10) up to a capacity below or equal to a maximum cell loading capacity of the centrifuge chamber (11), an overloading step (15) during which the centrifuge chamber (11) is further loaded with cell broth (10), thereby flushing out cells from the centrifuge chamber (11), collecting cells flushed out during the overloading step (15) as the waste fraction (12), and collecting cells from the chamber as the output fraction (13).
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Laboratory filters; filtration membranes for laboratory use;
laboratory filtration apparatus and filtering materials for
the filtration of liquids and gases; filters, for use in
relation to the following goods: laboratory apparatus in the
biopharmaceutical industry; filtration systems, devices, and
membranes for laboratory use. Filters for industrial use, namely for liquids, gases, and
biopharmaceutical applications; filtration units; filtration
units, namely filter cartridges, filter capsules, filter
modules, filter capsules and disposable filters, for
industrial purposes; filters, namely small filters,
disposable filters, filter cartridges, filter modules and
diaphragm filters being parts of filtering units or being
independent filters, for sterilisation and purification of
liquids and gases in the beverage, food and general chemical
industry; filters, specifically filter cartridges and
membrane filters for single use as parts of filter systems
or as stand-alone filters for the sterilization and
purification of liquids and gases in the electronics,
pharmaceutical, food, beverage, luxury food, cosmetics and
general chemical industries.
15.
SEPARATION SYSTEM AND METHOD FOR SEPARATING AND PURIFYING A TARGET COMPONENT
A separation system for separating and purifying a target component, a method for separating and purifying a target component, and the use of a crossflow diafiltration unit for processing a target phase. The system includes an aqueous-two phase extraction unit for aqueous-two phase extraction of the fluid, a separation unit for separating a target phase, and a crossflow diafiltration unit.
A smart single-use tube line assembly for use in a unit operation of a bioprocess including at least one tube line. The tube line includes a tube body surrounding a lumen through which a medium can flow. The tube line assembly also includes a functional element embedded in the tube body, the functional element being configured to perform an optical and/or electrical function. The tube line assembly further includes an interface for coupling both the lumen and the functional element of the tube line to another component. The tube line assembly still further includes a control unit for controlling the optical and/or electrical function.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
The invention relates to a an aeration device for a bioprocessing installation (2), comprising a housing (4), a circumferential rigid body (5), wherein the housing (4) comprises at least a first aeration channel (7) and a second aeration channel (8), wherein the housing (4) further comprises at least a first gas inlet port (10) and a second gas inlet port (11), and wherein the housing (4) further comprises a plurality of first gas discharge openings (12) and second gas discharge openings (13). It is proposed that the first aeration channel (7) and the second aeration channel (8) are arranged so as to overlap one another in the axial direction at least in sections.
B01F 23/231 - Mélange de gaz avec des liquides en introduisant des gaz dans des milieux liquides, p. ex. pour produire des liquides aérés par barbotage
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
A clamping device for fluidically and mechanically connecting two hose barbs. The clamping device includes a seal and a locking mechanism, wherein the locking mechanism can be transferred from a mounting condition to an assembled condition. In the mounting condition, the hose barbs can be inserted into the clamping device, while in the assembled condition, those hose barbs are locked in place in a position in which free ends of the hose barbs face each other and a seal coaxially aligns and fluid-tightly connects the free ends.
F16L 33/22 - Dispositions d'assemblage des manches avec des organes rigidesRaccords rigides pour manches, p. ex. éléments unitaires s'engageant à la fois dans deux manches avec moyens non mentionnés dans les groupes précédents pour saisir la manche entre l'extérieur et l'intérieur
F16L 33/18 - Dispositions d'assemblage des manches avec des organes rigidesRaccords rigides pour manches, p. ex. éléments unitaires s'engageant à la fois dans deux manches caractérisées par l'emploi de moyens d'étanchéité additionnels
19.
FILTRATION DEVICE, IN PARTICULAR SMALL-SCALE FILTRATION DEVICE FOR PRODUCTION OF BIOPHARMACEUTICALS
A filtration device (10), in particular a small-scale filtration device for production of biopharmaceuticals, comprises a housing including a top cover (12) having an unfiltrate inlet (18) and a bottom cover (14) having a filtrate outlet (22), and one or more filter supports (16) stacked between the top cover (12) and the bottom cover (14) along a vertical direction such that an upper side of each filter support (16) faces the top cover (12) and a lower side of each filter support (16) faces the bottom cover (14). Each filter support (16) is equipped with a flat upper filter (40) and a flat lower filter (42). Each filter (40, 42) has a filtrate side and an opposite unfiltrate side. The upper and lower filters (40, 42) are sealed to the upper and lower sides of the filter support (16), respectively, with the filtrate sides facing the filter support (16) and the unfiltrate sides facing away from the filter support (16). Unfiltrate flow paths lead from the unfiltrate inlet of the top cover (12) to the unfiltrate side of the upper filter (40) and to the unfiltrate side of the lower filter (42), wherein blocking means prevent unfiltrate from flowing directly from the unfiltrate inlet of the top cover (12) to the filtrate outlet (22) of the bottom cover (14). Filtrate flow paths lead from the filtrate sides of the upper and lower filters (40, 42) to the filtrate outlet (22) of the bottom cover (14) via at least one filtrate guiding channel (48a, 48b) formed on the upper side of the filter support (16) and at least one filtrate guiding channel (48a, 48b) formed on the lower side of the filter support (16). The upper filter (40) and the lower filter (42) are identically shaped.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
B01D 69/10 - Membranes sur supportSupports pour membranes
A tube holding apparatus includes a body, a mount, a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.
B67C 3/26 - Têtes de remplissageDispositifs pour introduire les têtes de remplissage dans les goulots des bouteilles
B65B 37/02 - Approvisionnement ou alimentation des matériaux solides fluents, plastiques ou liquides, ou de masses en vrac, de petits objets, à emballer par pesanteur
21.
TUBE HOLDING APPARATUSES FOR FILLING OF MULTIPLE CONTAINERS AND METHODS FOR USING THE SAME
A tube holding apparatus includes a body, a mount a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.
B65B 3/00 - Emballage de matériaux plastiques, de semi-liquides, de liquides ou de liquides et solides mélangés, dans des réceptacles ou récipients individuels, p. ex. dans des sacs ou sachets, boîtes, cartons, bidons ou pots
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
22.
TUBE HOLDING APPARATUSES FOR FILLING OF MULTIPLE CONTAINERS AND METHODS FOR USING THE SAME
A tube holding apparatus includes a body, a mount, a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.
B67C 3/26 - Têtes de remplissageDispositifs pour introduire les têtes de remplissage dans les goulots des bouteilles
B65B 37/02 - Approvisionnement ou alimentation des matériaux solides fluents, plastiques ou liquides, ou de masses en vrac, de petits objets, à emballer par pesanteur
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Laboratory filters; filtration membranes for laboratory use; laboratory filtration apparatus and filtering materials for the filtration of liquids and gases; filters, for use in relation to the following goods: laboratory apparatus in the biopharmaceutical industry; filtration systems, devices, and membranes for laboratory use. Filters for industrial use, namely for liquids, gases, and biopharmaceutical applications; filtration units; filtration units, namely filter cartridges, filter capsules, filter modules, filter capsules and disposable filters, for industrial purposes; filters, namely small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries.
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
(1) Laboratory filters; filtration membranes for laboratory use; laboratory filtration apparatus and filtering materials for the filtration of liquids and gases; filters, for use in relation to the following goods: laboratory apparatus in the biopharmaceutical industry; filtration systems, devices, and membranes for laboratory use.
(2) Filters for industrial use, namely for liquids, gases, and biopharmaceutical applications; filtration units; filtration units, namely filter cartridges, filter capsules, filter modules, filter capsules and disposable filters, for industrial purposes; filters, namely small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries.
25.
METHOD AND SYSTEM FOR TESTING THE INTEGRITY OF FILTERS
A method for testing integrity of a filter can include pressurizing an upstream side of the filter to a test pressure and performing a check step that includes determining a flow rate of fluid from the upstream side to a downstream side of the filter, comparing the determined flow rate with a flow range including a flow threshold, and setting stop criteria based on the comparison.
The present invention relates to a method for treating an ultrafiltration membrane, a method for producing an ultrafiltration membrane comprising the treatment method, as well as ultrafiltration membrane obtained by the treatment method or the production method.
A modular processing system (100) for biopharmaceutical processes includes (i) at least one first and at least one second processing unit (30, 32), which can be fluidically connected to each other; and (ii) at least one adapter plate (200), through which at least one fluid flow (14), flowing from the first processing unit (30) to the second processing unit (32), can flow. The adapter plate deflects the fluid flow between the first processing unit and the second processing unit at least partially; and/or controls the fluid flow, preferably, the pressure thereof, in an open loop or closed loop manner. A method for the modular construction of a processing system (100) for biopharmaceutical processes is also disclosed.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
07 - Machines et machines-outils
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
37 - Services de construction; extraction minière; installation et réparation
Produits et services
Chemicals and reagents for use in media and buffer preparation, seed train, filtration, chromatography, and virus clearance in biotechnology and biopharmaceutical industries; Chemicals for industrial and laboratory use in biopharmaceutical processing, including those for filtration and purification of biological materials. Machinery and automated equipment for media and buffer preparation, seed train, filtration, chromatography, and polishing; Industrial robots and apparatus for bioprocessing and manufacturing including filtration systems for the purification and separation of biological substances. Scientific, research, and laboratory apparatus for use in biopharmaceutical manufacturing, namely, apparatus for media and buffer preparation, seed train and production, filtration, chromatography, polishing and virus clearance; Downloadable and recorded software for biopharmaceutical processes, namely, software for media preparation, buffer preparation, seed train optimization, filtration, chromatography, polishing, and virus clearance; Control systems and software for automating biopharmaceutical processes, namely, software for filtration and purification processes; Interfaces and human-machine interface (HMI) software for managing and optimizing biopharmaceutical processes; Data collection and management software for process intensification systems; Devices for real-time monitoring and optimization for biopharmaceutical production. Industrial filtration apparatus for water, air, and gas purification; Chromatography apparatus for biopharmaceutical purification; Process systems and equipment for the filtration, purification, and separation of biological substances in biopharmaceutical processes, namely, filtration systems for bioprocessing. Installation and maintenance of process intensification systems for biopharmaceutical production.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific and technological research services in the field of biopharmaceuticals, specifically relating to bioprocess optimization, including media and buffer preparation, seed train, filtration, chromatography, and virus clearance; Design and development of computer software for biopharmaceutical process automation and control; Technical consultancy services related to biopharmaceutical process optimization, focusing on bioprocess steps namely, filtration, chromatography, and virus clearance; Software as a service (SaaS) for biopharmaceutical manufacturing, including media and buffer preparation, seed train, filtration, chromatography, polishing and virus clearance; IT-services in relation to cloud-based interfaces for managing biopharmaceutical manufacturing processes, namely, interfaces for filtration, purification, and virus clearance systems; Testing and validation services for bioprocessing equipment and systems; Process scale-up technical consulting and technical support for biopharmaceutical production.
The invention relates to a portable container holder for use in a bioprocess for holding and transporting a disposable container (3) which is filled with a fluid (2) and which has received a magnetically driven mixing element (4) for mixing the fluid (2), wherein the portable container holder (1) has a container receiving area (7) for receiving the disposable container (3), said receiving area having a drive location (8) where the mixing element (4) can be arranged in the disposable container (3) received in the container receiving area (7) such that the mixing element (4) can be driven by a drive unit (9) at the drive location (8). According to the invention, the portable container holder (1) has a transport securing unit (11) for securing and releasing the mixing element (4), which is arranged at the drive location (8), in its position, and the transport securing unit (11) has a magnet (10) which can be moved between a defined securing position (12), in which the mixing element (4) is secured in its position, and a defined release position (13), in which the mixing element (4) is released from its position.
The invention relates to a portable container holder for use in a bioprocess for holding and transporting a flexible disposable container (3) which is filled with a fluid (2). In particular, the fluid (2) is a fluid (2) which contains a purified pharmaceutical ingredient or a cultivation medium, and the portable container holder (1) has a container receiving area (6) for receiving the disposable container (3) and a cover (7) which can be installed on the container receiving area (6) in order to cover (7) the disposable container (3) received in the container receiving area (6), wherein the cover (7) has a fixing assembly (8) via which the disposable container (3) filled with the fluid (2) can be fixed in the container receiving area (6) in the installed state of the cover (7). According to the invention, the cover (7) has a spring assembly (9) which elastically supports the fixing assembly (8), and a spring force can be applied to the fixing assembly (8) in the direction of the spring via the spring assembly (9) in the installed state of the cover (7).
A device arrangement for separating cells from a culture medium in a bioprocess, in particular in a biopharmaceutical process, including a storage tank for the culture medium; a filtration module having a membrane adapted to be overflowed; an intake line connecting the storage tank to an unfiltrate inlet for supplying culture medium into the filtration module; a return line which connects a retentate-side outlet of the filtration module to the storage tank for returning retentate into the storage tank; a filtrate line which is connected to a permeate-side outlet of the filtration module for discharging filtrate; a first pump for maintaining a recirculation circuit; a backflush line which leads to a permeate-side connection and/or to the permeate-side outlet for supplying a rinsing liquid into the filtration module; and a second pump for conveying the rinsing liquid into the filtration module. A method of separating cells from a culture medium.
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
17 - Produits en caoutchouc ou en matières plastiques; matières à calfeutrer et à isoler
Produits et services
Filter modules, namely filter capsules, filter candles, filter cassettes, coil modules, filter coils, filter coils in connection with filter centrifuges, band filters, small filters, small filters in connection with centrifuge tubes and as centrifugal concentrators, disposable filters; membrane filters and filter matting being parts of machines, for use in biotechnology, environmental protection, for the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and for use in genetic engineering, medicine and in laboratories, and for treatment and analysis of water and effluent; filters being parts of machines; membrane filters for use as part of machines. Laboratory filters; filtering units for laboratory use; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors sold as a set for laboratory use; membranes for filtration (laboratory use); filters for use with laboratory chromatography apparatus; membrane filters and filter matting for laboratories with adsorption properties, membrane adsorbers, namely adsorption membranes, ion exchange membranes, ligand membranes and activated membranes in the form of hollow fibre membranes, tube membranes and flat membranes as strips or cut to size for use in apparatus, filters and filter modules for the aforesaid fields of application; membrane filters and filter matting as parts of microtitre plates; membrane filters and filter matting as parts of diagnostic tests such as diagnostic assays and immunoassays; membrane filters and filter matting as parts of filter systems or as independent filters for chromatographic analyses and chemical separation, reconcentration, for sterilisation and ultrapurification of fluids; filters and filter modules for filtering and reconcentration of biological solutions, namely of viral and bacterial suspensions; filters and filter modules for treating blood and other bodily fluids. Air filters and filtering units, for industrial use; liquid filters and filtering units, for industrial use; filters for filtering fluids, filter modules, filter candles and filter capsules; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors, sold as a set, for industrial installations; filters for water filtering apparatus; cartridge filtration units [water treatment equipment]; filters for use with industrial chromatography apparatus; apparatus for water treatment and for preparing solutions in the pharmaceutical, medical and laboratory fields; equipment for de-ionising water; equipment for de-pyrogenisation of solutions and for separating harmful substances from fluids; filters and filter modules for desalination of protein solutions and other biological media; filters and filter modules for analysis and separation of ions, macromolecules and biomolecules, namely carbohydrates, peptides, proteins and nucleic acids and for separating heavy metals and harmful substances from fluids; filters for industrial use, namely, membrane filters and filter matting having applications in biotechnology, environmental protection, the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and in genetic engineering, medicine and laboratories, and the treatment and analysis of water and effluents. Membranes and semi-processed synthetic filtering materials; polymeric membranes; polymeric porous membranes in hollow fibre form; polymeric porous membranes in sheet form; transfer membranes of cellulose derivatives; transfer membranes of cellulose; transfer membranes of polyamides; transfer membranes of polyvinylidene fluoride; cross-linked polymeric membranes in sheet form; cross-linked polymeric membranes in hollow fibre form.
35.
DIATOMACEOUS EARTH COMPOSITION WITH A LOW ENDOTOXIN CONTENT
The present invention relates to a diatomaceous earth composition with a low endotoxin content, comprising an agglomerated mixture of calcined diatomaceous earth particles and water, wherein the mass ratio of calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the endotoxin content of the diatomaceous earth composition is equal to or less than 0.5 EU/mL. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition with a low endotoxin content. In another aspect, the present invention relates to the use of the diatomaceous earth composition with a low endotoxin content as a precoat agent for the precoat filtration in biopharmaceutical applications.
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
B01D 37/02 - Revêtement préalable des éléments filtrants ou de la substance filtranteAddition d'adjuvants de filtration au liquide à filtrer
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
B65B 55/02 - Stérilisation, p. ex. de paquets finis
B65D 65/40 - Emploi de stratifiés pour des buts particuliers d'emballage
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
36.
PRODUCT FOR PROVIDING MEMBRANE ELEMENTS AND MANUFACTURING METHOD
The invention relates to a product for providing membrane elements, comprising: a carrier film; and a membrane film, at least comprising: a support layer; and a membrane layer; the membrane film is releasably coupled to the carrier film; and the membrane film has a plurality of substantially discrete membrane elements. The invention also relates to a corresponding manufacturing process.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B32B 3/30 - Produits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche continue dont le périmètre de la section droite a une allure particulièreProduits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche comportant des cavités ou des vides internes caractérisés par une couche comportant des retraits ou des saillies, p. ex. des gorges, des nervures
B32B 7/06 - Liaison entre couches permettant une séparation sans difficultés
B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
B32B 23/06 - Produits stratifiés composés essentiellement de substances cellulosiques plastiques comprenant de telles substances comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique de papier ou de carton
B32B 23/08 - Produits stratifiés composés essentiellement de substances cellulosiques plastiques comprenant de telles substances comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique de résine synthétique
B32B 23/20 - Produits stratifiés composés essentiellement de substances cellulosiques plastiques comprenant des esters
B32B 27/08 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique d'une résine synthétique d'une sorte différente
B32B 27/10 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique de papier ou de carton
B32B 27/28 - Produits stratifiés composés essentiellement de résine synthétique comprenant des copolymères de résines synthétiques non complètement couverts par les sous-groupes suivants
B32B 37/12 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par l'usage d'adhésifs
B32B 37/18 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par les propriétés des couches toutes les couches existant et présentant une cohésion avant la stratification impliquant uniquement l'assemblage de feuilles ou de panneaux individualisés
B32B 38/10 - Enlèvement de couches ou de parties de couches, mécaniquement ou chimiquement
37.
BIOPROCESS SYSTEM FOR A BIOPROCESS OPERATION WITH A DISPLAY ARRANGEMENT FOR DISPLAYING SYSTEM INFORMATION ABOUT THE BIOPROCESS SYSTEM
The invention relates to a bioprocess system for a bioprocess operation with a display arrangement (21) for displaying system information about the bioprocess system (1), wherein the bioprocess system (1) comprises system components (6) comprising at least one monitored system component (22), wherein the system components (6) can be assembled into an assembled state in which the bioprocess system (1) is operational for the bioprocess operation and can be disassembled into a disassembled state in which the bioprocess system (1) is not operational for the bioprocess operation, wherein the bioprocess system (1) comprises a control arrangement (24) and the display arrangement (21) comprises at least one display component (25), wherein in an assembled state of the bioprocess system (1) during a bioprocess operation the control arrangement (24) displays process information via the display arrangement (21) and/or wherein during assembly of the bioprocess system (1) the control arrangement (24) displays assembly information via the display arrangement (21), wherein the process information and/or the assembly information concern at least the monitored system component (22) and wherein the display arrangement (21) comprises at least one display component (25). It is proposed that the display component (25) comprises a light emitting element (27) arranged separate from the monitored system component (22) and arranged next to or on the monitored system component (22) and that the control arrangement (24) is configured to display via the light emitting element (27) the process information and/or the assembly information relating to the monitored system component (22).
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
G05B 19/409 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par l'utilisation de l'entrée manuelle des données [MDI] ou par l'utilisation d'un panneau de commande, p. ex. commande de fonctions avec le panneauCommande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par les détails du panneau de commande ou par la fixation de paramètres
G06F 9/448 - Paradigmes d’exécution, p. ex. implémentation de paradigmes de programmation
G05B 19/40 - Systèmes à boucle ouverte, p. ex. utilisant un moteur pas à pas
G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Microcarriers for use in manufacturing, laboratory use, and research use; protein-coated microcarrier beads for use in manufacturing, laboratory use, and research use; non-protein coated microcarrier beads for use in manufacturing, laboratory use, and research use; microcarriers for use in preparing cell cultures and in cell culture applications; kits consisting of microcarriers for use in manufacturing, laboratory use, and research use; microcarriers contained in sterilized bags for use in manufacturing, laboratory use, and research use
The invention relates to a method for inactivating viruses in a fluid, in which method: a starting fluid (AF) containing active viruses is mixed with a virus-inactivating reagent (R1) in a first mixing assembly (2) to form a reactive fluid (F); the active viruses are inactivated via incubation of the reactive fluid (F); and the inactivation of the viruses in the reactive fluid (F) is stopped by mixing the reactive fluid (F) with a further reagent (R2) or by removing the virus-inactivating reagent (R1) from the reactive fluid (F), as a result of which a resulting fluid (RF) is produced. According to the invention, the active viruses are inactivated via incubation of the reactive fluid (F) in a container assembly (3) which comprises a plurality of separate containers (4) and differs from the first mixing assembly (2), wherein the reactive fluid (F) is conducted from the first mixing assembly (2) to the container assembly (3) prior to incubation.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
The invention relates to a method for generating and purifying viral vectors (V), wherein the viral vectors (V) are generated by cells in a fluid (F) and wherein the fluid (F) comprising the viral vectors (V) is guided through a tangential flow filtration arrangement (2) for purification, whereby the viral vectors (V) are purified in the fluid (F). It is proposed that the cells and cell debris from the cells, which are contained in the fluid (F) comprising the viral vectors (V) after generating the viral vectors (V), are at least partially separated from the viral vectors (V) by a fluidized bed centrifuge (5) before purification by the tangential flow filtration arrangement (2).
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci
The present invention relates to methods for the purification of viruses, virus-like particles, extracellular vesicles, proteins having a diameter of 5 nm or more, protein complexes having a diameter of 5 nm or more, nucleic acids having a diameter of 5 nm or more, protein-nucleic acid complexes having a diameter of 5 nm or more, and/or molecules having a diameter of 5 nm or more, by filtration-supported polyalkylene glycol precipitation, and to filtration modules that can be used in said methods.
Embodiments include a device for continuous virus inactivation during a protein production process comprising a first and a second fluid inlet, a first mixer, and a fluid outlet. A first liquid stream containing a target protein is introducible into the device through the first fluid inlet and is combinable in a predefined volume ratio with a second, virus-inactivating liquid stream introducible into the device through the second fluid inlet to form a third, reactive liquid stream which is conducted through the first mixer for mixing in order to generate predefined, virus-inactivating conditions. The device further comprises a head part and, downstream of the first mixer and upstream of the fluid outlet, a residence time arrangement fluidically connected to the head part for provision of a minimum residence time of the third stream, wherein the head part and the residence time arrangement are rigidly fastened to each other.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
43.
ULTRASONIC SENSOR SYSTEMS FOR CHARACTERIZING PARTICLE SUSPENSIONS
Systems and methods for characterizing a plurality of particles suspended in a solution are described. In some embodiments, an ultrasonic interrogation signal may be emitted into a solution including a plurality of particles suspended in the solution. A resulting ultrasonic spectrum may be sensed and provided to a trained statistical model of the solution. The trained statistical model may then determine one or more properties of the plurality of particles.
G01N 29/036 - Analyse de fluides en mesurant la fréquence ou la résonance des ondes acoustiques
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 29/34 - Génération des ondes ultrasonores, sonores ou infrasonores
G01N 29/44 - Traitement du signal de réponse détecté
G01N 29/46 - Traitement du signal de réponse détecté par analyse spectrale, p. ex. par analyse de Fourier
A method for operating a bioprocess installation with an electronic process control and at least one bioprocess unit, wherein the bioprocess unit comprises a cell broth source with a first receptacle for cell broth including cultivation media and cells, establishing a culture environment for cell cultivation and/or bio production, wherein the bioprocess unit comprises a clarification setup with a centrifuge for the clarification of the cell broth by centrifugation, with a liquid pumping arrangement assigned to the centrifuge and with a liquid network with a number of liquid lines communicating with the liquid pumping arrangement, wherein out of a first culture environment established by the first receptacle, the cell broth is transfered to the centrifuge via the liquid network, which centrifuge is operated in a forward operation for cell separation and/or cell washing and in a backward operation for cell discharging.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
The invention relates to a method for operating a continuous downstream process, in particular a continuous virus activation or inline dilution process, using a bio-process arrangement (1), wherein the bio-process arrangement (1) has a compensating container (2) with a first fluid inlet (3), configured for introduction of a concentrate stream, in particular a product or buffer concentrate stream, into the compensating container (2), with at least one second fluid inlet (4), configured for introduction of a diluent stream, in particular a product or buffer diluent stream, into the compensating container (2), with a fluid outlet (5), configured to discharge a liquid stream from the compensating container (2), wherein the bio-process arrangement (1) has a conveying arrangement (6) for fluid conveyance, which is allocated to the first fluid inlet (3) and to the second fluid inlet (4) for conveying in each case at least one liquid stream into the compensating container (2), and is allocated to the fluid outlet (5) for conveying a liquid stream out of the compensating container (2), and wherein the bio-process arrangement (1) has an electronic process control (7). It is proposed that the electronic process control (7) adapts, by controlling the conveying arrangement (6) in an open-loop and/or closed-loop manner, a fill level in the compensating container (2) such that a predefined minimum fill level in the compensating container (2) is always reached.
B01F 23/40 - Mélange de liquides avec des liquidesÉmulsion
B01F 35/83 - Formation d'un rapport prédéterminé des substances à mélanger en commandant le rapport entre plusieurs débits, p. ex. en utilisant des dispositifs de détection ou de commande du débit
B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Cartridges for filtering machines; filters for machines. Laboratory filters. Filters for industrial and household use (terms too vague in
the opinion of the International Bureau - Rule 13 (2) (b) of
the Common Regulations). filters for industrial
installations (terms too vague in the opinion of the
International Bureau - Rule 13 (2) (b) of the Common
Regulations).
filter cartridges for water purification;
filters for water filtering apparatus; water purification
filters; water treatment filters; water filters for
industrial purposes; industrial installations for filtering
liquids; water filtering apparatus; water filtering
installations; water filtering units; filters (not being
parts of machines) as components of filtration systems or as
independent filters for the sterilization and purification
of liquids and gases for the electronic, pharmaceutical,
food, luxury consumer goods and cosmetics industries in
general.
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Filter housings being parts of machines; filters being parts
of machines; filters for gases [machines]; filters for
machines; membrane filters for use as parts of machines. Filtering units for laboratory use; laboratory filters. Air filters; air filters for industrial use; air filters for
industrial installations; filters for cleaning and
sterilizing air; filters for gases [household or industrial
installations]; filters for cleaning and sterilizing gases
[parts of industrial installations]; filter elements for the
air vents of water supply tanks; filters for industrial and
household use (term considered too vague by the
International Bureau - Rule 13 (2) (b) of the Regulations);
filters for industrial installations (term considered too
vague by the International Bureau - Rule 13 (2) (b) of the
Regulations); filters for refrigeration systems; filters for
use with bioreactors and fermenters; filters for venting
storage tanks; industrial air filter machines; air filter
installations; filters, in particular filter cartridges and
membrane filters for single use as parts of filter systems
or as stand-alone filters for the sterilization and
purification of liquids and gases in the electronics,
pharmaceutical, food, beverage, luxury goods, cosmetics and
general chemical industries.
48.
METHOD FOR PERFORMING AN INTEGRITY TEST ON A TESTING CONSUMABLE OF A BIOPROCESS INSTALLATION
The invention relates to a method for performing an integrity test on a testing consumable (1) of a bioprocess installation using a test arrangement (2), wherein during a test routine (26), which is being performed by a test control unit (3) of the test arrangement (2), a predetermined test procedure is being applied to the testing consumable (1) via the test arrangement (2) and an integrity state is being derived from process data that have been collected during the test routine (26). It is proposed that during the test routine (26), early process data (27), that are being generated by a testing sensor arrangement (4) of the test arrangement (2) in an early stage of the test procedure, are being used to determine the integrity state of the testing consumable (1) by correlating in a correlating step (28) the early process data (27) to a system model (29) of a reference module (30), which reference module (30) emulates a, in particular integral, testing consumable (1) only in view of predetermined process data.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
B01D 65/10 - Test de membranes ou d'appareils à membranesDétection ou réparation de fuites
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
G01M 3/22 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour tuyaux, câbles ou tubesExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour raccords ou étanchéité de tuyauxExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour soupapes
G01N 15/08 - Recherche de la perméabilité, du volume des pores ou de l'aire superficielle des matériaux poreux
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Laboratory filters; Filtration membranes for laboratory use; Laboratory filtration apparatus and filtering materials for the filtration of liquids and gases; Filters, for use in relation to the following goods: Laboratory apparatus in the biopharmaceutical industry; Filtration units, For laboratory use. Filters, For industrial purposes; Filtration units; Filtration units, namely Filter cartridges, Filter capsules, Filter modules, Filter capsules and Disposable filters, For industrial purposes; Filters, namely Small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; Filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries.
50.
HOLDING DEVICE FOR A CONTAINER, HAVING A MAGNETIC DRIVE FOR A SEPARATE AGITATOR SHAFT
The invention relates to a holding device (26) for a container, in particular a bioreactor, comprising a magnetic drive (30) for a separate agitator shaft (28) and a lever device (10) for releasing the agitator shaft (28) from the magnetic drive (30). The magnetic drive (30) has a first coupling side (32) and the agitator shaft (28) has a second coupling side (34) of a magnetic coupling, said second coupling side being connectable to the first coupling side (32). The lever device (10) has at least one pressure portion (22; 64) and is pivotable between a closing position and a release position. As the lever device (10) is pivoted into the release position, the pressure portion (22; 64) is moved downwards in order to act directly or indirectly on the agitator shaft (28).
B01F 33/453 - Mélangeurs magnétiquesMélangeurs avec agitateurs à entraînement magnétique en utilisant des éléments d'agitation supportés ou suspendus
B01F 27/213 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins caractérisés par leurs arbres de rotation caractérisés par la liaison avec l'entraînement
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Laboratory filters; Filtration membranes for laboratory use; Filters, for use in relation to the following goods: Laboratory apparatus in the biopharmaceutical industry; Filtration units, For laboratory use; Breather filters, For laboratory use. Filters, For industrial purposes; Filtration units, namely Filter cartridges, Filter capsules and Disposable filters, For industrial purposes; Filters, namely Small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; Filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries; Air filters; Air filters for industrial use; Air filters for industrial installations; Gas filters (industrial installations); Industrial air filter machines; Air filtering installations; Filters for purifying gaseous media and sterile ventilation of closed containers, conduits and tube systems; Filters for cleaning and sterilizing air; Parts of industrial installations, namely Filters for cleaning and sterilizing gases; Filters, for use in relation to the following goods: Transport container; Filters, for use in relation to the following goods: Containers, of plastic; Container attachment filters; Ventilation filters, For industrial purposes; Filters for the sterile gas exchange of containers; Filter elements for the air vents of water supply tanks; Filters for venting storage tanks; Filters for refrigeration systems; Filters, for use in relation to the following goods: Bio-reactors and Fermenters.
52.
METHOD OF CHANGING CULTURE MEDIUM OF A CULTURE USING SPINFILTERS
The present invention relates to a method of expanding stem cells cultured as cell aggregates in a suspension culture changing culture medium and a method of medium exchange for the same cells characterized in the use of a rotating mesh such as a spinfilter device. The present invention further relates to a use of a rotating mesh for medium exchange in a suspension culture of stem cells.
The invention relates to a method for operating a bioprocess installation (1) for production of a bioproduct, wherein the bioprocess installation (1) comprises a source receptacle (2) for cell cultivation, a harvest receptacle (3) for bioproduction and a clarification setup (4) with a centrifuge (12), wherein the source receptacle (2) is operated in a cyclical production mode comprising the steps of: a) starting the cyclical production mode in the source receptacle (2) b) cultivating the cells in the source receptacle (2), thereby obtaining a cell broth (7) comprising cultivated cells, c) discharging a discharge fraction (16) of the cell broth (7) from the source receptacle (2), d) combining a restart fraction (17) of the cell broth (7) with fresh cultivation medium (8) and repeating step b), e) repeating steps c) and d) at least once and/or f) discharging the cell broth (7) obtained from step d) from the source receptacle (2) stopping the cyclical production mode, obtaining a discharge fraction (16), wherein the method further comprises the steps of: i) centrifuging the discharge fraction (16) via the centrifuge (12), thereby separating the discharge fraction (16) into at least a centrifuged discharge fraction (19) and supernatant (14) and preferably bioproduct, ii) operating the harvest receptacle (3) in a production mode, wherein steps i) and ii) are executed at least twice.
C12M 1/107 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens pour recueillir les gaz de fermentation, p. ex. le méthane
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
17 - Produits en caoutchouc ou en matières plastiques; matières à calfeutrer et à isoler
Produits et services
Filter modules, namely filter capsules, filter candles, filter cassettes, coil modules, filter coils, filter coils in connection with filter centrifuges, band filters, small filters, small filters in connection with centrifuge tubes and as centrifugal concentrators, disposable filters; membrane filters and filter matting being parts of machines, for use in biotechnology, environmental protection, for the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and for use in genetic engineering, medicine and in laboratories, and for treatment and analysis of water and effluent; filters being parts of machines; membrane filters for use as part of machines. Laboratory filters; Filtering units for laboratory use; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors sold as a set for laboratory use; membranes for filtration [scientific]; filters for use with laboratory chromatography apparatus; membrane filters and filter matting with adsorption properties, membrane adsorbers, namely adsorption membranes, ion exchange membranes, ligand membranes and activated membranes in the form of hollow fibre membranes, tube membranes and flat membranes as strips or cut to size for use in apparatus, filters and filter modules for the aforesaid fields of application; membrane filters and filter matting as parts of microtitre plates; membrane filters and filter matting as parts of diagnostic tests such as diagnostic assays and immunoassays; membrane filters and filter matting as parts of filter systems or as independent filters for chromatographic analyses and chemical separation, reconcentration, for sterilisation and ultrapurification of fluids; filters and filter modules for filtering and reconcentration of biological solutions, namely of viral and bacterial suspensions; filters and filter modules for treating blood and other bodily fluids. Filters and filtering units, for industrial use; filters for filtering fluids, filter modules, filter candles and filter capsules; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors, sold as a set, for industrial installations; Filters for water filtering apparatus; Cartridge filtration units [water treatment equipment]; filters for use with industrial chromatography apparatus; apparatus for water treatment and for preparing solutions in the pharmaceutical, medical and laboratory fields; equipment for de-ionising water; equipment for de-pyrogenisation of solutions and for separating harmful substances from fluids; filters and filter modules for desalination of protein solutions and other biological media; filters and filter modules for analysis and separation of ions, macromolecules and biomolecules, namely carbohydrates, peptides, proteins and nucleic acids and for separating heavy metals and harmful substances from fluids; filters for industrial use, namely, membrane filters and filter matting having applications in biotechnology, environmental protection, the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and in genetic engineering, medicine and laboratories, and the treatment and analysis of water and effluents. Membranes and semi-processed synthetic filtering materials; Polymeric membranes; Polymeric porous membranes in hollow fibre form; Polymeric porous membranes in sheet form; Transfer membranes of cellulose derivatives; Transfer membranes of cellulose; Transfer membranes of polyamides; Transfer membranes of polyvinylidene fluoride; Cross-linked polymeric membranes in sheet form; Cross-linked polymeric membranes in hollow fibre form.
The invention relates to a method for a dynamic in-line mixing process of a pressurized medium (1), which contains a liquid and at least one additional liquid or solid constituent, in a bioprocess assembly (3). The liquid is combined with the at least one additional liquid or solid constituent in a specified volume ratio at an opening point (4) in order to form a resulting liquid flow (5), wherein the bioprocess assembly (3) has a pump assembly (8) with a first pump (9), the first pump (9) is arranged in the line (7) of the line assembly (6), the first pump (9) is designed as a rotary pump (10), in particular a centrifugal pump, which is designed for a dynamic in-line mixing process of the medium (1), the first pump (9) has a liquid inlet (9a) which forms the suction side of the pump when operated as intended and a liquid outlet (9b) which forms the pressure side of the pump when operated as intended, and the medium (1) is conducted through the rotary pump (10) for a dynamic in-line mixing process. According to the invention, the medium flows through the rotary pump (10) in the opposite flow direction, in comparison to the intended operation, for the dynamic in-line mixing process.
A device assembly for controlling an integrated continuous pharmaceutical or biopharmaceutical manufacturing process including a first process equipment for performing a first process step; a second process equipment for performing a second process step subsequent to the first process step; a single measuring unit for measurement of a set of signals of a liquid process medium at a single location, the measured signals depending on first and second parameters; and an evaluation and control unit for evaluating the measured signals to determine values of the first and second parameters. The evaluation and control unit determines first and second corrective feedback based on the values of the first and second parameters, respectively. The evaluation and control unit controls the first process step by providing the first corrective feedback to the first process equipment and controls the second process step by providing the second corrective feedback to the second process equipment.
Various embodiments are directed to a valve switching system for selectively interconnecting components of a bioprocess installation, comprising a valve switching cassette and an actuator block. It is proposed, that the valve switching cassette comprises a perforated backer plate securing a valve membrane structure to a cassette manifold, that the actuator block comprises a drive membrane structure with at least one drive membrane and a perforated backer plate securing the drive membrane structure to an actuator block body, wherein for selectively switching valve units, an actuator of the actuator block may urge the drive membrane structure through aligned perforation holes of both backer plates into engagement with the valve membrane structure.
G01N 30/46 - Modèles d'écoulement utilisant plus d'une colonne
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
58.
VALVE SWITCHING SYSTEM FOR SELECTIVELY INTERCONNECTING COMPONENTS OF A BIOPROCESS INSTALLATION
x,yx,yx,y), an actuator of the actuator block (16) may urge the drive membrane structure (23) through aligned perforation holes (25, 26) of both backer plates (22, 24) into engagement with the valve membrane structure (20).
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
F16K 7/00 - Dispositifs d'obturation à diaphragme, p. ex. dont un élément est déformé, sans être déplacé entièrement, pour fermer l'ouverture
G01N 30/46 - Modèles d'écoulement utilisant plus d'une colonne
G01N 30/32 - Contrôle des paramètres physiques du fluide vecteur de la pression ou de la vitesse
Disclosed is inter alia a method for validating a filter unit, wherein the method comprises: - guiding a fluid flow of a fluid, after the fluid flow passed through the filter unit, to a measurement area that is connected to the filter unit, wherein within the measurement area the fluid is exposed to at least one alternating electric field between at least two electrodes; - obtaining at least one electric signal between the at least two electrodes, wherein the at least one electric signal is at least affected by whether one or more cells of a plurality of cells in the fluid pass through the measurement area; and - determining, at least partially based on the obtained at least one electric signal, at least one validity information indicating a validity of the filter unit.
A bioreactor system (10) for carrying out a biological process comprises a container (12) for receiving a liquid biological medium and a gas supply facility for feeding various gases from gas sources (38, 40, 42, 44) into the container (12) in a controlled manner. The gas supply facility has a plurality of gas outlet lines (28, 30, 32) which open into one or more gas supply devices (20) and/or into an overlay gas outlet in the interior of the container (12). Each gas outlet line (28, 30, 32) is connected to multiple gas sources (38, 40, 42, 44) by a respective gas supply line (46, 52, 56, 58) or by a respective branch (48, 50, 54, 60) of a gas supply line (46, 52, 56, 58). A mass flow regulator (62), which is connected to a control unit, is arranged in each gas supply line (46, 52, 56, 58) and in each branch (48, 50, 54, 60). Such a bioreactor system for carrying out a biological process preferably comprises a controller, which comprises a master regulator for a controlled variable, at least one sensor associated with the master regulator and one or more follower regulators with actuators (14, 62), the manipulated variables of which influence the controlled variable in a targeted manner. The controller is designed such that a setpoint value for the controlled variable can be prespecified to the master regulator, the at least one sensor is used for repeated determination of an actual value of the controlled variable, and the master regulator provides to the follower regulators an output signal dependent upon the deviation of the actual value of the controlled variable from the setpoint value of the controlled variable. Control profiles, which are dependent upon the output signal of the master regulator, are assigned to the follower regulators. According to a first alternative, the control profiles contain setpoint values for the actuators (14, 62) of the follower regulators, and the controller is designed such that the setpoint values for the actuators (14, 62) can be input in the physical unit of their manipulated values. According to a second alternative, the control profiles contain setpoint values for a parameter that relates directly to the biological process and can be influenced in a targeted manner by the actuators (14, 62), and the controller is designed such that it automatically assigns setpoint values for the actuators of the follower regulators to the parameter setpoint values.
A method of molding an article includes positioning a dissolvable insert within a mold, filling the mold with material to form an article within the mold and about the dissolvable insert, and at least partially dissolving the dissolvable insert from within the article. The dissolvable insert forms internal features of the article and includes a porous core.
B29C 45/44 - Démoulage ou éjection des objets formés d'objets à contre-dépouille
B29C 33/52 - Moules ou noyauxLeurs détails ou accessoires comportant des moyens ou conçus spécialement pour faciliter le démoulage d'objets, p. ex. des objets à contre-dépouille solubles ou fusibles
The invention relates to a continuous flow centrifuge (1) comprising a rotor (6). The continuous flow centrifuge (1) comprises a connecting strand (12) having connection lines (16, 17), via which an exchange of media in containers (8a, 8b) arranged in the centrifugation chambers of the rotor (6) is possible. According to the invention, a temperature-control supply line (14) and a temperature-control discharge line (16) for a connecting strand temperature-control fluid extends through the connecting strand (12) in order to counteract a heating of the connecting strand (12) due to flexing and friction occurring therein. The connecting strand temperature-control fluid flows through the temperature-control supply line (14) and the temperature-control discharge line (15) in opposing flow directions. An electronic control unit (28) has a control logic which controls the connecting strand temperature-control power of a connecting strand temperature-control circuit (36) in an open-loop or closed-loop manner.
The invention relates to a flow-through centrifuge (1), which can be used for example for biotechnological applications, in particular in the form of a blood centrifuge (2). A drive and/or transmission assembly (19) of the through-flow centrifuge (1) has a planetary transmission (62). At least one planetary belt pulley (34; 36) is rotatably mounted on a rotating planet carrier (18) in the planetary transmission (62), and the torque of the planetary belt pulley (34; 36) is transmitted via a belt (33; 37), wherein the planet carrier (18) and the belt pulley (34; 36) are driven at different rotational speeds. According to the invention, the planet carrier (18) is held via a belt-tensioning unit (17) which rotates together with the planet carrier (18), and the distance (42) between the planet carrier (18) and a rotor axis (4) can be modified via the belt-tensioning unit (17) in order to set the tension of the belt (33; 37).
The invention relates to a continuous-flow centrifuge comprising a rotor which has at least one centrifugation chamber and rotates about a rotor axis (7) at a rotor speed. The continuous-flow centrifuge comprises a connecting strand (12) through which connecting lines (16, 17) extend. A medium can be supplied to the centrifugation chamber, and the medium can be discharged from the centrifugation chamber, via the connecting lines (16, 17) during operation of the continuous-flow centrifuge with the rotor rotating. One end region (18) of the connecting strand (12) is fixed to the housing, whereas the other end region (19) of the connecting strand (12) rotates with the rotor. To prevent the connecting strand (12) from twisting, the connecting strand (12) is guided in a compensation-rotor guide device (20) (in particular a guide tube (21)) which rotates about the rotor axis (7) at half the rotor speed. According to the invention, the compensation-rotor guide device (20) has a guide contour (27), the radius of curvature (32) of which is greater in a first guide-contour section (28) than the radius of curvature (33) in a second guide-contour section (29). As a result, the service life of the connecting strand (12) can be increased.
A method for mounting at least one component on an installation includes attaching a carrier directly or indirectly to the installation, where the installation has at least one frame with at least two arms, at least one base plate, and at least one deformable element. The method further includes displacing the component toward the deformable element such that the deformable element is displaced from a receiving state (AUZ), in which the deformable element is ready to receive the component of the installation, toward a locked state (ARZ), as a result of which the deformable element surrounds and mounts the component of the installation at least in part.
A method for providing an integrity test of a double filter capsule can include providing the double filter capsule in such a way that in a filtration process the medium to be filtered flows in its flow direction from an upstream chamber in the housing through a first filter into an intermediate chamber between the first filter and a second filter and then through the second filter to an outlet. The housing can have an upstream-chamber access point for feeding a test fluid into the upstream chamber and an intermediate-chamber access point for feeding the test fluid into the intermediate chamber. Additional steps can include providing a connecting line between the upstream-chamber access point and the intermediate-chamber access point and determining the state of integrity of the double filter capsule on the basis of at least two test phases.
B01D 65/10 - Test de membranes ou d'appareils à membranesDétection ou réparation de fuites
B01D 29/11 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants avec des éléments filtrants en forme de sac, de cage, de tuyau, de tube, de manchon ou analogue
B01D 29/56 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants à plusieurs éléments filtrants caractérisés par leur agencement relatif montés en série
67.
CHROMATOGRAPHIC MATERIAL AND METHOD OF PRODUCING SAME
The present invention relates to a chromatographic material comprising a polymer network material-based self-supporting bi-continuous separation matrix for adsorptive material separation in liquid media, and a method of producing the chromatographic material comprising a polymer network material-based self-supporting bi-continuous separation matrix.
B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 20/285 - Absorbants ou adsorbants poreux à base de polymères
The invention is directed to a method for producing a roll (1) or sheet of membrane units (2) for a membrane product (3) such as a lateral flow test from a roll (6) or sheet of membrane material (7), by means of a primary production arrangement (9), wherein the roll (6) or sheet of membrane material (7) is processed into a roll (1) or sheet of membrane units (2) in a primary processing routine, wherein in the primary processing routine, for generating the membrane units (2), a fluidic structure (11), in particular a hydrophobic structure, for defining fluid flow through the membrane material (7) is introduced into the membrane material (7) by means of a processing tool (12), wherein an evaluation routine is performed by means of an evaluation arrangement (15) comprising a sensor arrangement (16) and an evaluation control (17). It is proposed that in the evaluation routine, evaluation images (18) of the fluidic structures (11) of the membrane units (2) are generated by means of the sensor arrangement (16) and evaluation data (19) are generated by means of the evaluation control (17) and that the evaluation data (19) represent the deviation in predefined geometrical properties of the fluidic structure (11) in the respective evaluation image (18) with respect to the fluidic structure (11) in a reference image (21).
The present invention relates to automated nanoparticle synthesis systems and computer-implemented methods of monitoring and controlling a process of manufacturing lipid nanoparticles (LNPs) containing nucleic acid cargo. The present invention furthermore relates to a computer program product comprising computer-readable instructions, which, when loaded and executed on a computer system, causes the computer system to perform operations according to said methods.
A method for ensuring a microbiological purity of a single-use device for carrying out a biotechnological process, the single-use device including at least one gamma-sterilizable component which is formed from materials suitable for a sterilization by gamma radiation, and at least one non-gamma-sterilizable subunit which contains a material unsuitable for a sterilization by gamma radiation. Both the component and the subunit each have an area that comes into contact with a process medium when the biotechnological process is carried out. The method includes the steps of sterilizing the gamma-sterilizable component by gamma radiation; protecting the medium-contacting area of the gamma-sterilizable component by a sterile barrier; sterilizing the non-gamma-sterilizable subunit with superheated steam; protecting the medium-contacting area of the non-gamma-sterilizable subunit by a sterile barrier; removing the sterile barriers; and mounting the gamma-sterilized component and the superheated steam-sterilized subunit in the single-use device immediately after removing the sterile barriers.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
A61L 2/07 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques de la chaleur des gaz chauds de la vapeur
71.
Multidirectional Tilting Mechanism and a Method of Operating the Same
A tilting mechanism including a base, a tilting deck, four hinges, and a lifting member. Each hinge is positioned adjacent a corner of the base and the tilting deck. Each hinge includes a globe and a receiver with the globe or the receiver secured to the base frame or the deck frame and the other secured to the other of the base or the tilting deck. Each hinge includes a locking member that selectively secures a globe within a respective receiver. The lifting member is secured at a center of the base frame and a center of the deck frame. The lifting member is configured to urge the tilting deck away from the base such that selective engagement allows for tilting of the tilting deck relative to the base in at least four directions.
B62B 3/08 - Voitures à bras ayant plus d'un essieu portant les roues servant au déplacementDispositifs de direction à cet effetAppareillage à cet effet comportant des réceptacles de chargement à bascule
B62B 3/02 - Voitures à bras ayant plus d'un essieu portant les roues servant au déplacementDispositifs de direction à cet effetAppareillage à cet effet comportant des parties réglables, rabattables, attachables, détachables ou transformables
B67D 7/84 - Carters, armoires ou châssisChariots ou supports mobiles du même genre
The invention relates to a centrifuge (19), in particular a continuous-flow centrifuge, a biotechnical centrifuge or a blood centrifuge. The centrifuge (19) is provided with a coolant circuit (1). According to the invention, the outlet side of a controllable compressor (4) is connected to an inlet side of an evaporator (2) via a bypass line (5) with a valve (20) arranged therein. In a normal operating mode, when the valve (20) is closed, the cooling of a centrifuge bowl (3) occurs exclusively via the control of the compressor (4) and an expansion unit (6). However, if the target temperature in the centrifuge bowl (3) falls below a tolerance range, the valve (20) is opened in order to bring about a heating process and thereby a returning of the temperature in the centrifuge bowl (3) to within the tolerance range.
The present invention relates to tangential flow filtration/chromatography systems, the use thereof, and methods of separation, particularly simultaneously separating one or more target molecules from cells, cell debris and further contaminants contained in e.g. fermentation broth or any other particulate and impurity containing, non-clarified liquid.
B01D 15/22 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à la structure de la colonne
The present invention relates to a filter module comprising an ester-based membrane and at least one boundary member, wherein the peripheral region of the membrane is connected to the at least one boundary member, and wherein the surface of the membrane is saponified in the regions other than the peripheral region connected to the at least one boundary member. Further, the present invention relates to a method of producing such filter module and to the use of such filter module.
B01D 65/00 - Accessoires ou opérations auxiliaires, en général, pour les procédés ou les appareils de séparation utilisant des membranes semi-perméables
A tilting mechanism including a base, a tilting deck, four hinges, and a lifting member. Each hinge is positioned adjacent a corner of the base and the tilting deck. Each hinge includes a globe and a receiver with the globe or the receiver secured to the base frame or the deck frame and the other secured to the other of the base or the tilting deck. Each hinge includes a locking member that selectively secures a globe within a respective receiver. The lifting member is secured at a center of the base frame and a center of the deck frame. The lifting member is configured to urge the tilting deck away from the base such that selective engagement allows for tilting of the tilting deck relative to the base in at least four directions.
B60P 1/16 - Véhicules destinés principalement au transport des charges et modifiés pour faciliter le chargement, la fixation de la charge ou son déchargement avec un mouvement de basculement de l'élément supportant ou contenant la charge actionné par un fluide
E05D 15/50 - Suspensions pour battants permettant des manœuvres alternées pour ouverture à l'un ou l'autre des deux bords opposés
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
B62B 3/08 - Voitures à bras ayant plus d'un essieu portant les roues servant au déplacementDispositifs de direction à cet effetAppareillage à cet effet comportant des réceptacles de chargement à bascule
The application relates to a sensor holding device for holding a sensor device, in particular a clamp-on flow measurement sensor, the sensor holding device comprising: a holding body configured for holding the sensor device, wherein the holding body comprises: a sensor holding device-side engaging means for engaging with a sensor device-side engaging means of the sensor device when the sensor device is held by the holding body; and a securing means connected to the holding body for securing the sensor device at the holding body, the securing means being moveable relative to the holding body to a first position and to a second position, wherein the securing means moved into the first position allows placing the sensor device onto the holding body and removing the sensor device from the holding body, and wherein the securing means moved into the second position and the sensor holding device-side engaging means engaging the sensor device-side engaging means restrict relative movement of the sensor device along three directions with respect to the holding body such that the sensor device is secured at the holding body.
A computer-implemented method can configure and/or setup and/or control a downstream process for processing a biomass, including receiving at least one measurement value of at least one feature of an upstream process by which the biomass to be processed in the downstream process has been obtained and/or of at least one feature of a downstream process stage or operation, determining at least one downstream process parameter based on the received at least one measurement value, arid configuring and/or setup and/or controlling at least one downstream process stage or process operation based on the determined at least one downstream process parameter.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
A chromatography system is provided. The chromatography system is configured to process a feed fluid containing a plurality of components, wherein at least one component of the plurality of components of the feed fluid is a target component. The chromatography system comprises: a flow path comprising a plurality of fluid control components configured to control a fluid flow; a stationary phase, wherein the stationary phase is at least one membrane adsorber connected to the flow path and the stationary phase is configured to isolate the target component. The flow path is configured such that harvesting of the target component is optimized.
B01D 15/24 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au traitement des fractions à répartir
B01D 15/12 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à la préparation de l'alimentation
B01D 15/14 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à l'introduction de l'alimentation dans l'appareil
Various embodiments relate to a digital control unit of a bioprocess arrangement for controlling a bioprocess, wherein the digital control unit comprises a local data storage and a local processor unit, wherein the digital control unit comprises a bioprocess interface for sending and receiving bioprocess control data, wherein the digital control unit is configured to execute a bioprocess control routine via the local processor unit to control the bioprocess, wherein in the bioprocess control routine, the digital control unit generates bioprocess data from the actuator data and/or the sensor data and/or the user control command data. It is proposed that the digital control unit is configured to execute a signing routine via the local processor unit and that in the signing routine, the digital control unit digitally signs documentation data, derived from the bioprocess data, by generating a digital signature.
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
H04L 9/00 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité
80.
FILTER SYSTEM USABLE AS CELL CULTURE CLARIFICATION FILTER IN PROTEIN PURIFICATION
The present invention relates to a filter system, which can be used as a clarification filter/depth filter for cell culture clarification before chromatography and/or ultrafiltration for protein purification, as well as to a method of separating cells and other contaminants from a fluid containing one or more target components by employing the filter system of the present invention.
B01D 15/12 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à la préparation de l'alimentation
B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
The present invention relates to isolated nucleic acid molecules, comprising a functional mammalian EGR-1 (early growth response protein 1) promoter region that is operatively linked to a gene encoding a fluorescent protein and controls expression of said gene. The present invention further relates to nucleic acid vectors, comprising said nucleic, cells comprising said nucleic acids or vectors, being capable of sensing and indicating fluid shear stress acting on themselves, and methods of generating the same. Furthermore, the present invention relates to methods of evaluating fluid shear stress acting on cells in real-time during the operation of a biotechnological device or system, methods of evaluating a biotechnological device or system with respect to fluid shear stress acting on cells caused by operation of said device or system, and methods of designing a biotechnological device or system, said methods using said cells.
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
82.
DISTRIBUTOR ASSEMBLY, IN PARTICULAR FOR A SEPARATION UNIT OF A MODULAR PROCESS DEVICE ARRANGEMENT
A distributor assembly, which is provided in particular for a separation unit of a modular process device arrangement, including a fluid distributor device having a plurality of fluid ports, wherein the fluid distributor device can selectively establish and block fluid communications between the fluid ports. The distributor assembly further includes a connecting element and a retaining element. The connecting element is adapted to be attached to one of the fluid ports, and the distributor assembly includes an associated mounting slot at the fluid port. The mounting slot is adapted to the shape of the retaining element such that the retaining element can be inserted into the mounting slot up to a defined retaining position, in which the retaining element engages the connecting element and fixes it in place.
B01D 65/00 - Accessoires ou opérations auxiliaires, en général, pour les procédés ou les appareils de séparation utilisant des membranes semi-perméables
B01D 15/10 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement
83.
SMALL VOLUME SYSTEM AND METHODS OF EVALUATING THE STABILITY OF BIOPHARMACEUTICAL COMPOSITIONS
An analysis container includes an outer tube and a plurality of inner tubes. The outer tube defines a buffer volume that is configured to receive a buffer material. The plurality of inner tubes is disposed within the buffer volume. Each inner tube has an inner diameter equal to or less than 6 mm and is configured to receive a biopharmaceutical composition therein. The outer tube is configured such that the buffer material and the biopharmaceutical composition are axially frozen.
G01N 25/04 - Recherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant les changements d'état ou de phaseRecherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant le frittage du point de fusionRecherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant les changements d'état ou de phaseRecherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant le frittage du point de congélationRecherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant les changements d'état ou de phaseRecherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant le frittage du point de ramollissement
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
84.
MODULAR DEVICE FOR FIXED ARRANGEMENT AND INTERCONNECTION OF INDIVIDUAL SEPARATION UNITS AND/OR FUNCTION UNITS
A modular device for a fixed arrangement and interconnection of individual separation units and/or first functional units for performing one or more unit operations in a biotechnological process. The modular device includes a plurality of distributor caps provided for attachment to the separation units and/or first functional units. The distributor caps each have: a fluid distribution mechanism having a working connection and at least two supply or discharge connections, wherein the fluid distribution mechanism can assume at least two defined switching positions; connection mechanisms for establishing a flow communication between a fluid inlet or outlet of the separation unit or the first functional unit and the working connection of the fluid distribution mechanism; coupling mechanisms for establishing a rigid mechanical coupling and a flow communication with an adjacent distributor cap; and an interface for changing the switching positions of the fluid distribution mechanism.
B01D 29/90 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants comportant des dispositifs d'alimentation ou d'évacuation d'alimentation
An analysis container includes an outer tube and a plurality of inner tubes. The outer tube defines a buffer volume that is configured to receive a buffer material. The plurality of inner tubes is disposed within the buffer volume. Each inner tube has an inner diameter equal to or less than 6 mm and is configured to receive a biopharmaceutical composition therein. The outer tube is configured such that the buffer material and the biopharmaceutical composition are axially frozen.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
A method for conducting a bioprocess with a digital control unit of a bioprocess arrangement, wherein the digital control unit comprises a local data storage and a local processor unit, wherein the digital control unit comprises a bioprocess interface for sending and receiving bioprocess control data, wherein bioprocess data are generated by the digital control unit, wherein a bioprocess control routine is executed by the local processor unit to control the bioprocess, wherein in the bioprocess control routine, the bioprocess data are generated by the digital control unit from actuator data and/or sensor data and/or user control command data. It is proposed that a signing routine is initiated by the local processor unit in the data safety routine to be executed by an external signing unit(s).
G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
H04L 67/125 - Protocoles spécialement adaptés aux environnements propriétaires ou de mise en réseau pour un usage spécial, p. ex. les réseaux médicaux, les réseaux de capteurs, les réseaux dans les véhicules ou les réseaux de mesure à distance en impliquant la commande des applications des terminaux par un réseau
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
A method for conducting a bioprocess with a digital control unit of a bioprocess arrangement, wherein the digital control unit comprises a local data storage and a local processor unit, wherein bioprocess data are generated by the digital control unit. It is proposed, that in a data safety routine, a documentation routine and a signing routine are executed, that in the documentation routine, documentation data are generated from the bioprocess data and that in the signing routine, a cryptographic private key is extracted from private key data and the documentation data are digitally signed with the cryptographic private key by generating a digital signature and that the documentation routine is executed continuously during the bioprocess and that the signing routine is executed discontinuously during the bioprocess in several signing cycles according to a signing strategy, which defines trigger events for initiating the signing routine.
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
H04L 9/00 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité
88.
BIOREACTOR FOR CELL CULTURE WITH REUSABLE REACTOR VESSEL AND OPTICAL SPECTROSCOPY INTERFACE
A bioreactor for cell cultivation comprises a reusable reactor vessel (16), preferably made of stainless steel, for receiving a fluid, and an optical spectroscopy interface (14) including an adapter (10) and a single-use optical spectroscopy insert (12). The reusable reactor vessel (16) has a wall (18) and a port formed in the wall (18). The adapter (10) is configured to be fixed to the port in a predefined position at the port. The single-use optical spectroscopy insert (12) is configured to be accommodated and fixed in the adapter (10), or the insert (12) is an integral part of the adapter (10).
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
89.
SYSTEM FOR DETECTING A MEASUREMENT VARIABLE OF A FLUID BEING CONDUCTED IN A FLUID-CONDUCTING LINE, FLOW-THROUGH DEVICE FOR ARRANGING ON A FLUID-CONDUCTING LINE AND FOR ATTACHING A FLOWMETER, AND USE OF A FLOW-THROUGH DEVICE
The invention relates to a system for detecting a measurement variable of a fluid being conducted in a fluid-conducting line, said system having: - a flowmeter, in particular an ultrasonic flow meter, for detecting the measurement variable, - a flow-through device (10) for arranging on the fluid-conducting line and for attaching the flowmeter for detecting the measurement variable of the fluid being conducted by the line, said flowmeter having: - a first and second connection (12, 14), by means of which the flow-through device (10) can be connected to the fluid-conducting line, and - a measurement region (16) which is arranged between the first connection (12) and the second connection (14) and which can be coupled to the flowmeter for detecting the measurement variable, wherein the first connection (12), the measurement region (16), and the second connection (14) define a flow path (A) for the fluid through the flow-through device (10), and the measurement region (16) has at least two contact surfaces (20), which extend at least partly along the flow path (A), for contacting the flowmeter. The at least two contact surfaces (20) are designed to separate a coupling means under the effect of a pressing force, and the flowmeter is designed so as to exert at least the pressing force onto the at least two contact surfaces (20) by means of a coupling of the flowmeter to the measurement region (16). The invention additionally relates to a flow-through device and to a use thereof.
G01F 1/667 - Dispositions de transducteurs pour les débitmètres à ultrasonsCircuits pour faire fonctionner les débitmètres à ultrasons
G01F 1/66 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en mesurant la fréquence, le déphasage, le temps de propagation d'ondes électromagnétiques ou d'autres types d'ondes, p. ex. en utilisant des débitmètres à ultrasons
G01F 15/00 - Détails des appareils des groupes ou accessoires pour ces derniers, dans la mesure où de tels accessoires ou détails ne sont pas adaptés à ces types particuliers d'appareils, p. ex. pour l'indication à distance
G01F 15/18 - Supports ou moyens de raccordement pour les compteurs
An organizer assembly including a belt and a ribbon. The ribbon has a first clamp member, a second clamp member, and a first carrier portion. The first clamp member is configured to receive a conduit or a support to fix the conduit or the support relative to the ribbon. The belt includes an elongated body that is slidably received in the first carrier portion. The organizer assembly may include one or more adapters that are received in a respective clamp member of the ribbon and configured to receive a conduit or a support to fix the conduit or support relative to the ribbon.
F16L 3/22 - Supports pour tuyaux, pour câbles ou pour conduits de protection, p. ex. potences, pattes de fixation, attaches, brides, colliers spécialement adaptés pour supporter un certain nombre de tuyaux parallèles séparés par un espace
F16L 3/02 - Supports pour tuyaux, pour câbles ou pour conduits de protection, p. ex. potences, pattes de fixation, attaches, brides, colliers entourant partiellement le tuyau, le câble ou le conduit de protection
91.
METHOD OF REFERENCING AN ANALYTE MEASUREMENT IN A PURIFICATION SYSTEM
In a method of referencing an analyte measurement in a purification system during a process step in a biopharmaceutical process, the following sub-steps are performed during the same process step: guiding a medium through a purification unit (10) where the analyte is either removed from or added to the medium; measuring at least one parameter related to the presence and/or quantity of the analyte with a first measurement system (16) at a first measurement location upstream of the purification unit (10); measuring the at least one parameter with a second measurement system (18) at a second measurement location downstream of the purification unit (10); and referencing the upstream measurement to the downstream measurement, or referencing the downstream measurement to the upstream measurement.
DEVICE FOR ARRANGING ON A FLUID-CONDUCTING LINE AND FOR ATTACHING A FLOWMETER, AND METHOD FOR DETECTING A MEASUREMENT VARIABLE OF THE FLUID BEING CONDUCTED BY A LINE
The invention relates to a device (10) for arranging on a fluid-conducting line and for attaching a flowmeter, in particular an ultrasonic flowmeter, for detecting a measurement variable of the fluid being conducted by the line, having: - a first and a second connection (12, 14), by means of which the device (10) can be connected to the fluid-conducting line, - a measurement region (16) which is arranged between the first connection (12) and the second connection (14) and which can be coupled to the flowmeter in order to detect the measurement variable, wherein the first connection (12), the measurement region (16), and the second connection (14) define a flow path (A) for the fluid through the device (10), and - a flow-influencing element (22) which is arranged in and/or on the flow path (A) and which is arranged in front of the measurement region (16) in a provided flow direction of the fluid along the flow path (A) and at a distance therefrom. The flow-influencing element (22) is integrally formed with the first connection (12) or the second connection (14), and the flow-influencing element (22) is designed such that the flow flowing into the device (10) via the first connection (12), said fluid flowing into the device (10) with a substantially laminar flow, has a substantially turbulent flow in the measurement region (16).
G01F 1/66 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en mesurant la fréquence, le déphasage, le temps de propagation d'ondes électromagnétiques ou d'autres types d'ondes, p. ex. en utilisant des débitmètres à ultrasons
G01F 1/667 - Dispositions de transducteurs pour les débitmètres à ultrasonsCircuits pour faire fonctionner les débitmètres à ultrasons
G01F 15/00 - Détails des appareils des groupes ou accessoires pour ces derniers, dans la mesure où de tels accessoires ou détails ne sont pas adaptés à ces types particuliers d'appareils, p. ex. pour l'indication à distance
G01F 15/18 - Supports ou moyens de raccordement pour les compteurs
A clamp for closing a flexible tube includes an anvil and a hammer. The anvil includes a passage and a slot defined therein. The passage is configured to receive a flexible tube therethrough. The hammer is slidably received within the slot of the anvil. The hammer is securable in a first position in which the passage of the anvil is substantially unoccluded and a second position in which the passage of the anvil is occluded. The hammer and the anvil are configured to prevent fluid from flowing through the flexible tube received in the passage when the hammer is in the closed position. The hammer is substantially within the anvil in the closed position.
F16K 7/06 - Dispositifs d'obturation à diaphragme, p. ex. dont un élément est déformé, sans être déplacé entièrement, pour fermer l'ouverture à diaphragme tubulaire dont l'étranglement est assuré par une force extérieure radiale par tige filetée, came ou autre moyen mécanique
A61M 39/28 - Moyens de serrage pour l'écrasement des tubes flexibles, p. ex. brides de serrage à rouleaux
94.
BIOREACTOR SYSTEMS AND METHOD FOR OPERATING A BIOPROCESS
A bioreactor system for receiving a disposable bioreactor bag comprises a receiving container having a container wall which defines a receiving space in which the disposable bioreactor bag is received in an operating state of the bioreactor system. A stirring system projects at least partially into the receiving space and is designed and configured to stir a biomedium present in the disposable bioreactor bag in the operating state of the bioreactor system. At least one baffle, which makes the receiving space smaller and differs from the container wall, serves to reduce a laminar flow of the biomedium. A temperature control medium flows through at least part of the at least one baffle, said temperature control medium controlling the temperature of the baffle.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/06 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'introduction de gaz avec agitateur, p. ex. avec agitateur à turbine
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
95.
MULTIPORT DEVICE FOR CONNECTING A LOOP TO ONE PORT OF A BIOREACTOR, AND PERFUSION OR CONCENTRATED FED-BATCH SETUP FOR PERFORMING AN UPSTREAM PROCESS OF CELL CULTURE
A multiport device (42) for connecting a loop (36), preferably a tangential flow filtration loop or a sensor loop, to one port (34) of a bioreactor (32), preferably a single-use bioreactor (32), is configured to be fixed to the port (34) of the bioreactor (32). The multiport device (42) includes a first flow path (44) configured for 5 withdrawing fluid from the bioreactor (32), and a second flow path (52) configured for supplying fluid to the bioreactor (32). The first flow path (44) has a first end (48) adapted to be in fluid connection with the bioreactor (32), and a second end (50) adapted to be connected to an inlet of the loop (36). The second flow path (52) has an outer end (64) adapted to be connected to an outlet of the loop (36), and a 10 mouth (62) adapted to be in fluid connection with the bioreactor (32). The mouth (62) of the second flow path (52) is distanced from the first end (48) of the first flow path (44) by at least 5 mm, preferably 10 mm.
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
(1) Filter housings being parts of machines; filters being parts of machines; filters for gases [machines]; filters for machines; membrane filters for use as parts of machines.
(2) Filtering units for laboratory use; laboratory filters.
(3) Air filters; air filters for industrial use; air filters for industrial installations; filters for cleaning and sterilizing air; filters for gases [household or industrial installations]; filters for cleaning and sterilizing gases [parts of industrial installations]; filter elements for the air vents of water supply tanks; filters for industrial and household use (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulations); filters for industrial installations (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulations); filters for refrigeration systems; filters for use with bioreactors and fermenters; filters for venting storage tanks; industrial air filter machines; air filter installations; filters, in particular filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury goods, cosmetics and general chemical industries.
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Filter cartridges for filtering machines; filters for filtering machines Laboratory filters Water filters for industrial and household use; water filters for industrial installations; filter cartridges for water purification; filters for water filtering apparatus; water purification filters; water treatment filters; water filters for industrial purposes; industrial installations for filtering liquids, namely, apparatus for purification of liquids in the food and beverage industries being water filtering apparatus; water filtering apparatus; water filtering units; water filters not being parts of machines as components of filtration systems or as independent filters for the sterilization and purification of liquids and gases for the electronic, pharmaceutical, food, luxury consumer goods and cosmetics industries in general
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Filter housings for gas filters being parts of bioprocessing machines; filters being parts of bioprocessing machines for use in the biopharmaceutical industry; filters for removing contaminants from gases used in the biopharmaceutical industry; membrane filters for use as parts of bioprocessing machines Laboratory filters; Filtering units for laboratory use Air filters for industrial use; air filters for industrial installations; filters for cleaning and sterilizing air; filters for gases used in industrial installations; filters for cleaning and sterilizing gases as parts of industrial installations; filter elements for the air vents of water supply tanks; filters for refrigeration systems; filters for use with bioreactors and fermenters; filters for venting storage tanks; industrial air filter machines; air filter installations; air filters, in particular air filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury goods, cosmetics and general chemical industries
99.
MULTIPORT DEVICE FOR CONNECTING A LOOP TO ONE PORT OF A BIOREACTOR, AND PERFUSION OR CONCENTRATED FED-BATCH SETUP FOR PERFORMING AN UPSTREAM PROCESS OF CELL CULTURE
A multiport device for connecting a loop, preferably a tangential flow filtration loop or a sensor loop, to one port of a bioreactor, preferably a single-use bioreactor, is configured to be fixed to the port of the bioreactor. The multiport device includes a first flow path configured for withdrawing fluid from the bioreactor, and a second flow path configured for supplying fluid to the bioreactor. The first flow path has a first end adapted to be in fluid connection with the bioreactor, and a second end adapted to be connected to an inlet of the loop. The second flow path has an outer end adapted to be connected to an outlet of the loop, and a mouth adapted to be in fluid connection with the bioreactor. The mouth of the second flow path is distanced from the first end of the first flow path by at least 5 mm, preferably 10 mm.
A device assembly (10) for calibrating a single-use sensor (14) before, during or after a biopharmaceutical manufacturing process step comprises a single-use process equipment assembly for performing at least a part of the process step. The single-use process equipment assembly includes a flow line (12) through which a medium flows in a defined direction during the process step. The single- use process equipment assembly further includes an integrated single-use sensor (14) for measuring or detecting a physical or chemical property at a measurement location in the flow line (12). The device assembly (10) further comprises at least one calibration line (18) and at least one switching means (22) inserted into the flow line (12) upstream of the measurement location. The switching means (22) include a flow line inlet, a flow line outlet and a calibration line inlet connected to the calibration line (18). The switching means (22) are adapted to selectively switch between a first (main) flow path, in which the flow line inlet (26) and the flow line outlet (28) are opened while the calibration line inlet (30) is closed, and a second (calibration) flow path, in which the flow line inlet (26) is closed while the calibration line inlet (30) and the flow line outlet (28) are opened. The device assembly (10) comprises a dedicated reference means provided in the calibration line (18). The dedicated reference means includes a reference sensor (48) or a reference source or a reference standard solution (40) related to the physical or chemical property to be measured or detected by the single-use sensor (14). The calibration line (20) may also be provided downstream of the single-use sensor (14).
