Sartorius Stedim Biotech S.A.

France

Retour au propriétaire

1-100 de 1 041 pour Sartorius Stedim Biotech S.A. et 5 filiales Trier par
Recheche Texte
Affiner par
Type PI
        Brevet 870
        Marque 171
Juridiction
        États-Unis 482
        International 468
        Europe 64
        Canada 27
Propriétaire / Filiale
Sartorius Stedim Biotech GmbH 831
Sartorius Stedim North America Inc. 165
Satorius Stedim Biotech GmbH 24
[Owner] Sartorius Stedim Biotech S.A. 21
Cellca GmbH 3
Voir plus
Date
Nouveautés (dernières 4 semaines) 7
2025 juillet (MACJ) 3
2025 juin 9
2025 mai 8
2025 avril 1
Voir plus
Classe IPC
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie 200
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies 87
B01F 15/00 - Accessoires pour mélangeurs 60
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus 58
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes 53
Voir plus
Classe NICE
09 - Appareils et instruments scientifiques et électriques 116
11 - Appareils de contrôle de l'environnement 83
07 - Machines et machines-outils 58
10 - Appareils et instruments médicaux 36
42 - Services scientifiques, technologiques et industriels, recherche et conception 28
Voir plus
Statut
En Instance 110
Enregistré / En vigueur 931
  1     2     3     ...     11        Prochaine page

1.

SYSTEMS AND METHODS INVOLVING CONTROLLED OXYGEN RELEASE IN BIOMATERIALS

      
Numéro d'application 18853505
Statut En instance
Date de dépôt 2023-03-29
Date de la première publication 2025-07-17
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Akbari, Samin
  • Reif, Oscar

Abrégé

Some aspects of the disclosure are related to systems and methods for controlled oxygen release from biomaterials in vessels and unit operations or components of cell culture, cell containment, and/or bioreactor. Vessels, unit operations, devices, and/or components of the invention may be used to perform all or part of a biological and/or chemical process involving biologicals (e.g., a plurality of cells) in the presence of oxygen-releasing agents. In some embodiments, a system comprises a vessel comprises an oxygen-releasing agent configured to generate in-situ and release oxygen in a sustained manner. The presence of an oxygen-releasing agent may advantageously allow for high cell density fermentation and cell cultivation in a vessel and provide an alternative for supplemental gassing means (e.g., sparger, etc.). Some embodiments of the disclosure are directed to employing the oxygen-releasing agents in microfluidic or millifluidic systems.

Classes IPC  ?

  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse

2.

SEPARATION SYSTEM FOR SEPARATING AND PURIFYING A TARGET COMPONENT

      
Numéro d'application 18852416
Statut En instance
Date de dépôt 2023-03-30
Date de la première publication 2025-07-03
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Kruse, Thomas
  • Schmitz, Fabian
  • Kampmann, Markus

Abrégé

A separation system and methods for separating and purifying a target component include a separation system for separating and purifying a target component, a method for separating and purifying a target component, and the use of a single-pass crossflow diafiltration unit for integrally connecting a first and a second chromatography device.

Classes IPC  ?

  • B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
  • B01D 15/14 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à l'introduction de l'alimentation dans l'appareil
  • B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
  • B01D 61/16 - Prétraitement du courant d'alimentation
  • B01D 61/18 - Appareils à cet effet
  • C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux

3.

CONTAINERS INCLUDING INTERNAL MIXERS AND METHODS OF USE

      
Numéro d'application 18841916
Statut En instance
Date de dépôt 2023-03-01
Date de la première publication 2025-07-03
Propriétaire
  • Sartorius Stedim Biotech GmbH (Allemagne)
  • Trustees of Boston University (USA)
Inventeur(s)
  • Akbari, Samin
  • Holmes, Douglas
  • Yang, Yi
  • Pollard, David James
  • Barve, Sanika
  • Bailini, Alessandro
  • Nadal, Javier

Abrégé

Containers including internal mixers and actuators assemblies and related methods are generally described. In some embodiments, a container may include a mixer and an actuator, at least one of which may be located inside of the container. The actuator may actuate the mixer to induce flow within the container and mix the contents of the container with a low volumetric footprint and high mixing efficiency. In some embodiments, the actuator may be configured to deform the mixer, which may include one or more features which may be deformed out of plane in a Kirigami or Origami fashion. The actuator and mixer may be arranged in series or in parallel. The actuator may be used without a mixer to induce flow within the container. The actuator may be driven pneumatically, hydraulically, electrically, and/or in any other suitable manner.

Classes IPC  ?

  • B01F 31/44 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants avec des agitateurs effectuant un mouvement oscillatoire, vibratoire ou de secousses
  • B01F 35/513 - Récipients souples, p. ex. sacs supportés par des conteneurs rigides

4.

BIOREACTOR WITH FILTER UNIT AND METHOD FOR TREATING A CELL BROTH

      
Numéro d'application 19077199
Statut En instance
Date de dépôt 2025-03-12
Date de la première publication 2025-06-26
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Leuthold, Martin
  • Helling, Alexander
  • Grummert, Ulrich

Abrégé

A bioreactor having a filter unit and a method for treating a cell broth. The filter unit has a supply channel (2), a first filter medium (4), a retentate channel (1), a second filter medium (5) and a permeate channel (3), arranged so that the first filter medium delimits the supply channel and the retentate channel from one another; and the second filter medium delimits the retentate channel and the permeate channel from one another. The supply channel is connected to an inlet for a supply medium; the retentate channel is connected to an inlet for a cell broth and to an outlet for the cell broth; the permeate channel is connected to an outlet for a permeate; and the interior of the bioreactor is connected to the inlet for the cell broth and to the outlet for the cell broth.

Classes IPC  ?

  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • B01D 61/14 - UltrafiltrationMicrofiltration

5.

A TUBULAR FLOW DEVICE FOR ENABLING CONTROLLED FLOW OF A FLUID AT A MEASURING POINT

      
Numéro d'application EP2024086969
Numéro de publication 2025/132485
Statut Délivré - en vigueur
Date de dépôt 2024-12-17
Date de publication 2025-06-26
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Regen, Thomas
  • Wagner, Eva
  • Ludolph, Niclas
  • Maier, Friedrich

Abrégé

A tubular flow device (10) for enabling controlled flow of a fluid at a measuring point comprises an inlet flow channel (14) defining a main inflow direction, and an outlet flow channel (18) defining a main outflow direction. The flow device (10) further comprises a branching portion (22) where the inlet flow channel (14) is divided into a primary flow channel (24) and a secondary measurement channel (26), and a joining portion (36) where the primary flow channel (24) and the secondary measurement channel (26) open into the outlet flow channel (18). The measuring point is located in the secondary measurement channel (26). The primary flow channel (24) is longer than the secondary measurement channel (26) and has a constriction (42) downstream of the branching portion (22). A fluid entering the inlet flow channel (14) is divided into a primary flow flowing into the primary flow channel (24) and a secondary measurement flow flowing into the secondary measurement channel (26). The primary flow and the secondary measurement flow reach the joining portion (36) essentially at the same time, due to the Venturi effect caused by the constriction (42) of the primary flow channel (24).

Classes IPC  ?

  • G01F 1/44 - Tubes de Venturi
  • B33Y 80/00 - Produits obtenus par fabrication additive
  • G01F 1/661 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en mesurant la fréquence, le déphasage, le temps de propagation d'ondes électromagnétiques ou d'autres types d'ondes, p. ex. en utilisant des débitmètres à ultrasons en utilisant la lumière
  • G01F 5/00 - Mesure d'une fraction du débit volumétrique
  • G01F 15/00 - Détails des appareils des groupes ou accessoires pour ces derniers, dans la mesure où de tels accessoires ou détails ne sont pas adaptés à ces types particuliers d'appareils, p. ex. pour l'indication à distance
  • G01F 1/50 - Moyens de correction ou de compensation
  • G01F 15/14 - Revêtements, p. ex. avec un matériau spécial

6.

A METHOD OF PRODUCING DIFFERENTIATED CELLS FROM PLURIPOTENT STEM CELLS, CELL POPULATIONS OBTAINED BY THE METHOD, CORRESPONDING PHARMACEUTICAL COMPOSITIONS AND A SYSTEM FOR PRODUCING DIFFERENTIATED CELLS FROM PLURIPOTENT STEM CELLS

      
Numéro d'application EP2024087863
Numéro de publication 2025/133096
Statut Délivré - en vigueur
Date de dépôt 2024-12-20
Date de publication 2025-06-26
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Raddatz, Lukas
  • Austerjost, Jonas

Abrégé

The present invention inter alia relates to a method of producing differentiated cells from pluripotent stem cells, comprising providing at least one multicellular 3D aggregate derived from pluripotent stem cells cultured in a first suspension culture, inducing differentiation of the cells forming the at least one multicellular 3D aggregate, allowing a continuous release of differentiated cells from the multicellular 3D aggregate into the first suspension culture; and continuously separating the released differentiated cells from the first suspension culture. The present invention also relates to a cell obtained by the method and to a pharmaceutical composition comprising the cells. The invention further relates to a corresponding system for producing differentiated cells from pluripotent stem cells.

Classes IPC  ?

7.

BIOPROCESS ASSEMBLY WITH INTEGRATED FILTRATION AND SAMPLING SYSTEMS

      
Numéro d'application EP2024082436
Numéro de publication 2025/131467
Statut Délivré - en vigueur
Date de dépôt 2024-11-14
Date de publication 2025-06-26
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Grimm, Christian
  • Hoehse, Marek

Abrégé

A bioprocess assembly (10) comprises a separation system (12) and a sampling system (14). The sampling system (14) is fluidically connected to the separation system (12) and comprises a sampling membrane (32) such that the separation system (12) and the sampling membrane (32) provide a separate sampling channel (30). The sampling channel (30) comprises at least one fluidic connection (36) to receive a buffer and at least one fluidic connection (51) to a sampling station (50). Further, the sampling channel (30) comprises a counter pressure generating unit (48) and at least one sensor (40), wherein the counter pressure generating unit (48) is configured to adjust the pressure within the sampling channel (30) based on data collected by the at least one sensor (40).

Classes IPC  ?

  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • G01N 1/20 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide pour matériau coulant ou s'éboulant

8.

THERMAL SENSOR FOR BIOPHARMECUTICAL STORAGE CONTAINERS AND METHODS OF CORRELATING THERMAL SENSORS

      
Numéro d'application 18538761
Statut En instance
Date de dépôt 2023-12-13
Date de la première publication 2025-06-19
Propriétaire Sartorius Stedim North America Ins. (USA)
Inventeur(s)
  • Grumet-Avallone, Amy
  • Smit, Peter
  • Duerwald, Jake
  • Huhn, Matthew
  • Cutting, Jonathan
  • Sanchez, Marc
  • Sirotkin, Matvey

Abrégé

A storage container for aseptically storing and freezing a biopharmaceutical composition includes a frame, an expandable bladder, and a sensor system. The expandable bladder is supported within the frame having a filled state in which the expandable bladder is configured to hold the biopharmaceutical composition therein. The sensor system is secured to an exterior surface of the bladder. The sensor system is configured to transmit a signal indicative of a temperature of the exterior surface of the bladder which is correlated to a temperature of biopharmaceutical composition at a desired location within the expandable bladder in the filled state thereof.

Classes IPC  ?

  • A61J 1/16 - Supports pour récipients
  • A61J 1/18 - Dispositions pour indiquer l'état, p. ex. l'état stérile, du contenu du récipient

9.

DEVICE ASSEMBLY AND METHOD FOR A PRODUCTION-SCALE TANGENTIAL FLOW FILTRATION

      
Numéro d'application EP2024084439
Numéro de publication 2025/124987
Statut Délivré - en vigueur
Date de dépôt 2024-12-03
Date de publication 2025-06-19
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Hack, Alexander
  • Lobedann, Martin

Abrégé

A device assembly (10) for performing a production scale tangential flow filtration of a feed, preferably in a batch feed and bleed process, comprises a first loop (12) including a first tubing (20), a feed tank (22) and actuators and sensors adapted to the first tubing (20), and a second loop (14) including second tubing (28) and a filter (28), preferably a hollow fiber filter. The first loop (12) and the second loop (14) further include a common tubing section. The first loop (12) connects to the second loop (14) at a first connection point (16) upstream, or alternatively downstream, of the filter (28), and the second loop (14) connects to the first loop (12) at a second connection point (18) downstream, or alternatively upstream, of the filter (28), such that the first loop (12) supplies the feed from the feed tank (22) to the second loop (14) at the first connection point (16), or alternatively at the second connection point (18), and the second loop (14) supplies retentate to the first loop (12) at the second connection point (18) from where a part of the retentate is returned to the feed tank (22), or alternatively at the first connection point (14). At least all wetted parts of the device assembly (10) are single-use parts and the inner diameter of the first tubing (20) is smaller than the inner diameter of the second tubing (32).

Classes IPC  ?

  • B01D 61/18 - Appareils à cet effet
  • B01D 61/20 - AccessoiresOpérations auxiliaires
  • B01D 61/22 - Commande ou régulation
  • C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci

10.

THERMAL SENSOR FOR BIOPHARMECUTICAL STORAGE CONTAINERS AND METHODS OF CORRELATING THERMAL SENSORS

      
Numéro d'application IB2024062457
Numéro de publication 2025/126043
Statut Délivré - en vigueur
Date de dépôt 2024-12-10
Date de publication 2025-06-19
Propriétaire SARTORIUS STEDIM NORTH AMERICA INC. (USA)
Inventeur(s)
  • Grumet-Avallone, Amy
  • Smit, Peter
  • Duerwald, Jake
  • Huhn, Matthew
  • Cutting, Jonathan
  • Sanchez, Marc
  • Sirotkin, Matvey

Abrégé

A storage container for aseptically storing and freezing a biopharmaceutical composition includes a frame, an expandable bladder, and a sensor system. The expandable bladder is supported within the frame having a filled state in which the expandable bladder is configured to hold the biopharmaceutical composition therein. The sensor system is secured to an exterior surface of the bladder. The sensor system is configured to transmit a signal indicative of a temperature of the exterior surface of the bladder which is correlated to a temperature of biopharmaceutical composition at a desired location within the expandable bladder in the filled state thereof.

Classes IPC  ?

  • A01N 1/146 - Réceptacles non réfrigérés spécialement adaptés au transport ou au stockage de parties vivantes tout en les préservant
  • C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet

11.

KIRIGAMI MIXERS AND METHODS OF USE

      
Numéro d'application 18840766
Statut En instance
Date de dépôt 2023-03-01
Date de la première publication 2025-06-05
Propriétaire
  • Sartorius Stedim Biotech GmbH (Allemagne)
  • Trustees of Boston University (USA)
Inventeur(s)
  • Akbari, Samin
  • Holmes, Douglas
  • Yang, Yi
  • Pollard, David James

Abrégé

Kirigami mixing systems and related methods are generally described. In some embodiments, a mixing system includes one or more grippers configured to deform a portion of a flexible container containing fluid when undergoing axial deformation. The grippers may include features including slots, hinges, and spines to aid in the transition of the grippers between a closed and retracted configuration when the one or more grippers are deformed. The compression of the container subsequently result in fluid flow within the container which may mix or agitate the fluid. In some embodiments, the described grippers may be formed integrally with the flexible containers. In some embodiments, the mixing system may include a plurality of grippers arranged around the flexible container.

Classes IPC  ?

  • B01F 31/55 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants les matières à mélanger étant contenues dans un sac souple soumis à une déformation périodique
  • B01F 35/513 - Récipients souples, p. ex. sacs supportés par des conteneurs rigides

12.

CONTINUOUS FLOW CENTRIFUGE

      
Numéro d'application 19047345
Statut En instance
Date de dépôt 2025-02-06
Date de la première publication 2025-06-05
Propriétaire Sartorius Stedim North America Inc. (USA)
Inventeur(s) Tödteberg, Eckhard

Abrégé

The invention relates to a continuous flow centrifuge with a rotor. The continuous flow centrifuge comprises a connecting section with connection conduits. Via the connection conduits an exchange of media in receptacles arranged in centrifugation chambers of the rotor is possible. A temperature control supply conduit and temperature control discharge conduit for a connecting section temperature control fluid both extend through the connecting section in order to counteract heating of the connecting section as a result of the flexing work and friction occurring therein. The connecting section temperature control fluid flows through the temperature control supply conduit and the temperature control discharge conduit in opposite flow directions. An electronic control unit (28) comprises control logic which controls (open loop or closed loop) the connecting section temperature control circuit.

Classes IPC  ?

  • B04B 11/02 - Alimentation ou déchargement en continuSystèmes de commande à cet effet
  • B04B 15/02 - Autres accessoires pour centrifugeurs pour le refroidissement, le chauffage, ou l'isolation thermique

13.

METHOD OF OPERATING A BIOPROCESS ARRANGEMENT TO PERFORM AT LEAST ONE REPETITION OF A BIOPROCESS

      
Numéro d'application EP2024082774
Numéro de publication 2025/108910
Statut Délivré - en vigueur
Date de dépôt 2024-11-19
Date de publication 2025-05-30
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s) Cutting, Jonathan

Abrégé

The invention relates to a method of operating a bioprocess arrangement (1) to perform at least one repetition of a bioprocess, wherein the bioprocess arrangement (1) comprises at least one replaceable electronic component (8), wherein a process control system (7) controls the bioprocess arrangement (1), using a digital model (10). It is proposed that the replaceable electronic components (8) are removed and replaced by new electronic components (9), that the process control system (7) automatically detects the removal of the replaceable electronic components (8), automatically detects the presence of the new electronic components (9) and retrieves digital representations (11) of the new electronic components (9) based on the communication with the new electronic components (9), that the process control system (7) derives from the digital representations (11) of the replaceable electronic components (8) and the new electronic components (9) a functional relationship between the replaceable electronic components (8) and the new electronic components (9), that the process control system (7) replaces the digital representations (11) of the replaceable electronic components (8) with the digital representations (11) of the new electronic components (9) based on the functional relationship thereby updating the digital model (10), and, that the process control system (7) controls the bioprocess arrangement (1) to perform the bioprocess based 20 on the updated digital model (10).

Classes IPC  ?

  • G05B 19/418 - Commande totale d'usine, c.-à-d. commande centralisée de plusieurs machines, p. ex. commande numérique directe ou distribuée [DNC], systèmes d'ateliers flexibles [FMS], systèmes de fabrication intégrés [IMS], productique [CIM]
  • G05B 17/02 - Systèmes impliquant l'usage de modèles ou de simulateurs desdits systèmes électriques
  • H04L 12/40 - Réseaux à ligne bus
  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement

14.

FLOW-THROUGH CENTRIFUGE AND METHOD FOR BRINGING ABOUT AN OPERATIONAL STATE OF A FLOW-THROUGH CENTRIFUGE

      
Numéro d'application 19037842
Statut En instance
Date de dépôt 2025-01-27
Date de la première publication 2025-05-29
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s) Bittner, Fabian

Abrégé

The invention relates to a flow-through centrifuge which is used, for example, for biotechnical applications, in particular as a blood centrifuge. A driving arrangement and/or transmission arrangement of the flow-through centrifuge comprises a planetary gearset. In the planetary gearset, at least one planetary belt pulley is rotatably supported on a rotating planet carrier. A torque of the planetary belt pulley is transmitted via a belt. The planet carrier and the planetary belt pulley are driven at different rotational speeds. According to the invention, the planet carrier is held by a belt tensioning unit rotating with the planet carrier. A distance of the planet carrier from a rotor axis can be changed via the belt tensioning unit in order to adjust the belt tension of the belt.

Classes IPC  ?

  • B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p. ex. butyromètres
  • B04B 7/00 - Éléments des centrifugeurs
  • B04B 9/08 - Agencements des mécanismes de transmission
  • B04B 9/14 - Équilibrage des tambours rotatifs

15.

Valve switching system for selectively interconnecting components of a bioprocess installation

      
Numéro d'application 17699622
Numéro de brevet 12311287
Statut Délivré - en vigueur
Date de dépôt 2022-03-21
Date de la première publication 2025-05-27
Date d'octroi 2025-05-27
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s) Shukla, Dinesh

Abrégé

A valve switching system for selectively interconnecting components of a bioprocess installation, comprising a valve switching cassette and an actuator block. It is proposed, that the valve switching cassette comprises a perforated sandwich plate with perforation holes, which sandwich plate is placed between the cassette manifold and the actuator block body.

Classes IPC  ?

  • B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
  • F16K 11/22 - Soupapes ou clapets à voies multiples, p. ex. clapets mélangeursRaccords de tuyauteries comportant de tels clapets ou soupapesAménagement d'obturateurs et de voies d'écoulement spécialement conçu pour mélanger les fluides dont plusieurs éléments de fermeture ne se déplacent pas comme un tout actionnés par des organes de commande distincts chacun étant propre à une soupape, p. ex. conjugués pour former clapet à voies multiples
  • F16K 31/126 - Moyens de fonctionnementDispositifs de retour à la position de repos actionnés par un fluide le fluide agissant sur un diaphragme, un soufflet ou un organe similaire

16.

METHOD AND APPARATUS FOR VALIDATING A FILTER UNIT

      
Numéro d'application 19034946
Statut En instance
Date de dépôt 2025-01-23
Date de la première publication 2025-05-22
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Austerjost, Jonas
  • Söldner, Robert
  • Rafigh, Mehran
  • Scholz, Jochen

Abrégé

A method for validating a filter unit. The method includes guiding a fluid flow of a fluid after the fluid flow passed through the filter unit to a measurement area that is connected to the filter unit. The measurement area the fluid is exposed to is at least one alternating electric field between at least two electrodes. The method includes obtaining at least one electric signal between the at least two electrodes. The at least one electric signal is at least affected by whether one or more cells of a plurality of cells in the fluid pass through the measurement area. The method includes determining, at least partially based on the obtained at least one electric signal, at least one validity information indicating a validity of the filter unit.

Classes IPC  ?

  • G01N 15/08 - Recherche de la perméabilité, du volume des pores ou de l'aire superficielle des matériaux poreux

17.

METHOD OF OPERATING A BIOPROCESS ARRANGEMENT TO PERFORM AT LEAST ONE REPETITION OF A BIOPROCESS

      
Numéro d'application 18518102
Statut En instance
Date de dépôt 2023-11-22
Date de la première publication 2025-05-22
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s) Cutting, Jonathan

Abrégé

A method of operating a bioprocess arrangement to perform repetition of a bioprocess, wherein the bioprocess arrangement comprises a replaceable electronic component, wherein a process control system controls the bioprocess arrangement, using a digital model. The replaceable electronic components are removed and replaced by new electronic components, the process control system automatically detects the removal of the electronic components, automatically detects the presence of the new electronic components and retrieves digital representations of the new components, the process control system derives from the digital representations of the replaceable components and the new components a functional relationship, the process control system replaces the digital representations of the replaceable components with the digital representations of the new components based on the functional relationship thereby updating the digital model, and, that the process control system controls the bioprocess arrangement to perform the bioprocess based on the updated digital model.

Classes IPC  ?

  • G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques

18.

CONTINUOUS FLOW CENTRIFUGE AND COMPENSATION ROTOR GUIDING DEVICE

      
Numéro d'application 19022767
Statut En instance
Date de dépôt 2025-01-15
Date de la première publication 2025-05-15
Propriétaire Sartorius Stedim North America Inc. (USA)
Inventeur(s) Sander, Michael

Abrégé

A continuous flow centrifuge comprising a rotor comprising at least one centrifugation chamber and which is rotated about a rotor axis at a rotor speed, and a connecting section through which connecting conduits extend. A medium can be supplied to the centrifugation chamber via the connecting conduits during operation, and the medium can be discharged from the centrifugation chamber. One end section of the connecting section is fixed to the housing, while the other end section is rotated with the rotor. To avoid twisting of the connecting section, the connecting section is guided in a compensating rotor guiding device, which is rotated about the rotor axis at half the rotor speed. The compensating rotor guiding device may comprise a guiding contour whose radius of curvature in a first guiding contour section is larger than the radius of curvature in a second guiding contour section.

Classes IPC  ?

  • B04B 5/12 - Centrifugeurs dans lesquels l'action centrifuge agissant dans un récipient stationnaire est obtenue par des organes rotatifs autres que des tambours
  • B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p. ex. butyromètres
  • B04B 11/02 - Alimentation ou déchargement en continuSystèmes de commande à cet effet

19.

Pionic

      
Numéro d'application 1853475
Statut Enregistrée
Date de dépôt 2025-03-06
Date d'enregistrement 2025-03-06
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
  • 07 - Machines et machines-outils
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement
  • 37 - Services de construction; extraction minière; installation et réparation

Produits et services

Chemicals and reagents for use in media and buffer preparation, seed train, filtration, chromatography, and virus clearance in biotechnology and biopharmaceutical industries; chemicals for industrial and laboratory use in biopharmaceutical processing, including those for filtration and purification of biological materials. Machinery and automated equipment for media and buffer preparation, seed train, filtration, chromatography, and polishing; industrial robots and apparatus for bioprocessing and manufacturing including filtration systems for the purification and separation of biological substances. Scientific, research, and laboratory apparatus for use in biopharmaceutical manufacturing, namely, apparatus for media and buffer preparation, seed train and production, filtration, chromatography, polishing and virus clearance; downloadable and recorded software for biopharmaceutical processes, namely, software for media preparation, buffer preparation, seed train optimization, filtration, chromatography, polishing, and virus clearance; control systems and software for automating biopharmaceutical processes, namely, software for filtration and purification processes; interfaces and human-machine interface (HMI) software for managing and optimizing biopharmaceutical processes; data collection and management software for process intensification systems; devices for real-time monitoring and optimization for biopharmaceutical production. Industrial filtration apparatus for water, air, and gas purification; chromatography apparatus for biopharmaceutical purification; process systems and equipment for the filtration, purification, and separation of biological substances in biopharmaceutical processes, namely, filtration systems for bioprocessing. Installation and maintenance of process intensification systems for biopharmaceutical production.

20.

SAFECORE

      
Numéro d'application 019183593
Statut En instance
Date de dépôt 2025-05-07
Propriétaire Sartorius Stedim North America Inc. (USA)
Classes de Nice  ?
  • 10 - Appareils et instruments médicaux
  • 12 - Véhicules; appareils de locomotion par terre, par air ou par eau; parties de véhicules

Produits et services

Disposable containers specially designed for cryopreserving biopharmaceutical materials; protective rigid housing structures for receiving disposable containers for cryopreserving biopharmaceutical materials; frames for supporting disposable containers for cryopreserving biopharmaceutical materials, storage units for short or long storage of frames with supported disposable containers for cryopreserving biopharmaceutical materials. Transportation carts for disposable containers for cryopreserving biopharmaceutical materials.

21.

Pionic

      
Numéro d'application 1851388
Statut Enregistrée
Date de dépôt 2025-03-12
Date d'enregistrement 2025-03-12
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ? 42 - Services scientifiques, technologiques et industriels, recherche et conception

Produits et services

Scientific and technological research services in the field of biopharmaceuticals, specifically relating to bioprocess optimization, including media and buffer preparation, seed train, filtration, chromatography, and virus clearance; design and development of computer software for biopharmaceutical process automation and control; technical consultancy services related to biopharmaceutical process optimization, focusing on bioprocess steps namely, filtration, chromatography, and virus clearance; software as a service (SaaS) for biopharmaceutical manufacturing, including media and buffer preparation, seed train, filtration, chromatography, polishing and virus clearance; IT services in relation to cloud-based interfaces for managing biopharmaceutical manufacturing processes, namely, interfaces for filtration, purification, and virus clearance systems; testing and validation services for bioprocessing equipment and systems; process scale-up technical consulting and technical support for biopharmaceutical production.

22.

METHOD FOR PRODUCING A BIOPRODUCT

      
Numéro d'application 18290945
Statut En instance
Date de dépôt 2022-07-21
Date de la première publication 2025-03-27
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Saballus, Martin
  • Kampmann, Markus

Abrégé

Various embodiments provide a method for producing a bioproduct using a bioprocess installation. The bioprocess installation comprises an process control and a bioprocess unit. The bioprocess unit comprises a receptacle, a clarification unit with a centrifuge and a chromatography unit with a chromatograph. Cell broth obtained from the receptacle is lead through the clarification unit and the chromatography unit in a liquid stream. The clarification unit with its centrifuge is being operated in a centrifugation cycle comprising centrifugation steps. The chromatography unit with its chromatograph is being operated in a chromatography cycle comprising chromatography steps. The particle depletion can be less than 10% in particle concentration and that the execution of the steps assigned to the centrifugation cycle and the execution of the steps assigned to the chromatography cycle are at least partly being synchronized with each other by the process control in synchronization routines based on assigned synchronization strategies.

Classes IPC  ?

  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/26 - Inoculateur ou échantillonneur

23.

ULTRASONIC SENSOR SYSTEMS FOR CHARACTERIZING LIQUIDS

      
Numéro d'application 18885099
Statut En instance
Date de dépôt 2024-09-13
Date de la première publication 2025-03-27
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Akbari, Samin
  • Pollard, David James
  • Ganjian, Amin
  • Anderson, Phillip
  • Balke, Robert

Abrégé

Systems and methods for characterizing a physical and solution properties of liquids are described. In some embodiments, an ultrasonic interrogation signal may be emitted into a liquid such as a solubilized protein solution. A resulting ultrasonic spectrum may be sensed and provided to a trained statistical model of the solution. The trained statistical model may then determine one or more properties of the liquid. In some embodiments, the trained statistical model determines a viscosity of the liquid and/or a solubilized protein concentration of the liquid. In some embodiments, a trained statistical classification model configured to classify the liquid based, for example, on its contents or properties is used to improve modeling accuracy.

Classes IPC  ?

24.

CENTRIFUGE, METHOD FOR OPERATING A CENTRIFUGE AND COMPUTER-READABLE MEDIUM

      
Numéro d'application 18977545
Statut En instance
Date de dépôt 2024-12-11
Date de la première publication 2025-03-27
Propriétaire
  • Sigma Laborzentrifugen GmbH (Allemagne)
  • Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s) Tödteberg, Eckhard

Abrégé

The invention relates to a centrifuge, in particular a continuous flow centrifuge, a biotechnical centrifuge or a blood centrifuge. The centrifuge comprises a refrigerant circuit. According to the invention, the outlet side of a controllable compressor is connected to an inlet side of an evaporator via a bypass line with a valve arranged therein. In a normal operation mode, a centrifuge vessel is cooled exclusively via the control of the compressor and an expansion unit while the valve is closed. If, on the other hand, a tolerance range of the target temperature in the centrifuge vessel is left, the valve is opened in order to bring about heating and thus a return of the temperature in the centrifuge vessel to the tolerance range.

Classes IPC  ?

  • F25B 49/02 - Disposition ou montage des dispositifs de commande ou de sécurité pour machines, installations ou systèmes du type à compression
  • B04B 7/02 - BâtisCouvercles
  • B04B 13/00 - Systèmes de commande spécialement conçus pour les centrifugeursCommande à programme des centrifugeurs
  • B04B 15/02 - Autres accessoires pour centrifugeurs pour le refroidissement, le chauffage, ou l'isolation thermique

25.

Multidisc

      
Numéro d'application 019158367
Statut En instance
Date de dépôt 2025-03-18
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 07 - Machines et machines-outils
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement

Produits et services

Filter modules, namely, filter capsules, filter candles, filter cassettes, coil modules, filter coils, filter coils in connection with filter centrifuges, band filters, small filters, small filters in connection with centrifuge tubes and as centrifugal concentrators, disposable filters; Membrane filters and filter matting being parts of machines, for use in biotechnology, environmental protection, for the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and for use in genetic engineering, medicine and in laboratories, and for treatment and analysis of water and effluent; Filters being parts of machines; Membrane filters for use as part of machines. Laboratory filters; Filtering units for laboratory use; Liquid filter units, namely, filter cartridges, plastic hoses and hose connectors sold as a set for laboratory use; Membranes for filtration [scientific]; Filters for use with laboratory chromatography apparatus; Membrane filters and filter matting with adsorption properties, membrane adsorbers, namely adsorption membranes, ion exchange membranes, ligand membranes and activated membranes in the form of hollow fibre membranes, tube membranes and flat membranes as strips or cut to size for use in apparatus, filters and filter modules for the aforesaid fields of application; Membrane filters and filter matting as parts of microtitre plates; Membrane filters and filter matting as parts of diagnostic tests such as diagnostic assays and immunoassays; Membrane filters and filter matting as parts of filter systems or as independent filters for chromatographic analyses and chemical separation, reconcentration, for sterilisation and ultrapurification of fluids; Filters and filter modules for filtering and reconcentration of biological solutions, namely of viral and bacterial suspensions; Filters and filter modules for treating blood and other bodily fluids. Filters and filtering units, for industrial use; Filters for filtering fluids, filter modules, filter candles and filter capsules; Liquid filter units, namely, filter cartridges, plastic hoses and hose connectors, sold as a set, for industrial installations; Filters for water filtering apparatus; Cartridge filtration units [water treatment equipment]; Filters for use with industrial chromatography apparatus; Apparatus for water treatment and for preparing solutions in the pharmaceutical, medical and laboratory fields; Equipment for de-ionising water; Equipment for de-pyrogenisation of solutions and for separating harmful substances from fluids; Filters and filter modules for desalination of protein solutions and other biological media; Filters and filter modules for analysis and separation of ions, macromolecules and biomolecules, namely carbohydrates, peptides, proteins and nucleic acids and for separating heavy metals and harmful substances from fluids; Filters for industrial use, namely, membrane filters and filter matting having applications in biotechnology, environmental protection, the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and in genetic engineering, medicine and laboratories, and the treatment and analysis of water and effluents.

26.

SOLOHILL

      
Numéro d'application 1843761
Statut Enregistrée
Date de dépôt 2025-01-30
Date d'enregistrement 2025-01-30
Propriétaire Sartorius Stedim North America Inc. (USA)
Classes de Nice  ? 01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture

Produits et services

Microcarriers for use in manufacturing, laboratory use, and research use; protein-coated microcarrier beads for use in manufacturing, laboratory use, and research use; non-protein coated microcarrier beads for use in manufacturing, laboratory use, and research use; microcarriers for use in preparing cell cultures and in cell culture applications; kits consisting of microcarriers for use in manufacturing, laboratory use, and research use; sterilized bags containing microcarriers for use in manufacturing, laboratory use, and research use.

27.

PIONIC

      
Numéro de série 79422331
Statut En instance
Date de dépôt 2025-03-12
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ? 42 - Services scientifiques, technologiques et industriels, recherche et conception

Produits et services

Scientific and technological research services in the field of biopharmaceuticals, specifically relating to bioprocess optimization, including media and buffer preparation, seed train, filtration, chromatography, and virus clearance; design and development of computer software for biopharmaceutical process automation and control; technical consultancy services related to biopharmaceutical process optimization, focusing on bioprocess steps namely, filtration, chromatography, and virus clearance; software as a service (SaaS) for biopharmaceutical manufacturing, including media and buffer preparation, seed train, filtration, chromatography, polishing and virus clearance; IT services in relation to cloud-based interfaces for managing biopharmaceutical manufacturing processes, namely, interfaces for filtration, purification, and virus clearance systems; testing and validation services for bioprocessing equipment and systems; process scale-up technical consulting and technical support for biopharmaceutical production.

28.

Pionic

      
Numéro d'application 239443400
Statut En instance
Date de dépôt 2025-03-12
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ? 42 - Services scientifiques, technologiques et industriels, recherche et conception

Produits et services

(1) Scientific and technological research services in the field of biopharmaceuticals, specifically relating to bioprocess optimization, including media and buffer preparation, seed train, filtration, chromatography, and virus clearance; design and development of computer software for biopharmaceutical process automation and control; technical consultancy services related to biopharmaceutical process optimization, focusing on bioprocess steps namely, filtration, chromatography, and virus clearance; software as a service (SaaS) for biopharmaceutical manufacturing, including media and buffer preparation, seed train, filtration, chromatography, polishing and virus clearance; IT services in relation to cloud-based interfaces for managing biopharmaceutical manufacturing processes, namely, interfaces for filtration, purification, and virus clearance systems; testing and validation services for bioprocessing equipment and systems; process scale-up technical consulting and technical support for biopharmaceutical production.

29.

Pionic

      
Numéro d'application 239738400
Statut En instance
Date de dépôt 2025-03-06
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
  • 07 - Machines et machines-outils
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement
  • 37 - Services de construction; extraction minière; installation et réparation

Produits et services

(1) Chemicals and reagents for use in media and buffer preparation, seed train, filtration, chromatography, and virus clearance in biotechnology and biopharmaceutical industries; chemicals for industrial and laboratory use in biopharmaceutical processing, including those for filtration and purification of biological materials. (2) Machinery and automated equipment for media and buffer preparation, seed train, filtration, chromatography, and polishing; industrial robots and apparatus for bioprocessing and manufacturing including filtration systems for the purification and separation of biological substances. (3) Scientific, research, and laboratory apparatus for use in biopharmaceutical manufacturing, namely, apparatus for media and buffer preparation, seed train and production, filtration, chromatography, polishing and virus clearance; downloadable and recorded software for biopharmaceutical processes, namely, software for media preparation, buffer preparation, seed train optimization, filtration, chromatography, polishing, and virus clearance; control systems and software for automating biopharmaceutical processes, namely, software for filtration and purification processes; interfaces and human-machine interface (HMI) software for managing and optimizing biopharmaceutical processes; data collection and management software for process intensification systems; devices for real-time monitoring and optimization for biopharmaceutical production. (4) Industrial filtration apparatus for water, air, and gas purification; chromatography apparatus for biopharmaceutical purification; process systems and equipment for the filtration, purification, and separation of biological substances in biopharmaceutical processes, namely, filtration systems for bioprocessing. (1) Installation and maintenance of process intensification systems for biopharmaceutical production.

30.

PIONIC

      
Numéro de série 79423271
Statut En instance
Date de dépôt 2025-03-06
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
  • 07 - Machines et machines-outils
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement
  • 37 - Services de construction; extraction minière; installation et réparation

Produits et services

Chemicals and reagents for use in media and buffer preparation, seed train, filtration, chromatography, and virus clearance in biotechnology and biopharmaceutical industries; chemicals for industrial and laboratory use in biopharmaceutical processing, including those for filtration and purification of biological materials. Machinery and automated equipment for media and buffer preparation, seed train, filtration, chromatography, and polishing; industrial robots and apparatus for bioprocessing and manufacturing including filtration systems for the purification and separation of biological substances. Scientific, research, and laboratory apparatus for use in biopharmaceutical manufacturing, namely, apparatus for media and buffer preparation, seed train and production, filtration, chromatography, polishing and virus clearance; downloadable and recorded software for biopharmaceutical processes, namely, software for media preparation, buffer preparation, seed train optimization, filtration, chromatography, polishing, and virus clearance; control systems and software for automating biopharmaceutical processes, namely, software for filtration and purification processes; interfaces and human-machine interface (HMI) software for managing and optimizing biopharmaceutical processes; data collection and management software for process intensification systems; devices for real-time monitoring and optimization for biopharmaceutical production. Industrial filtration apparatus for water, air, and gas purification; chromatography apparatus for biopharmaceutical purification; process systems and equipment for the filtration, purification, and separation of biological substances in biopharmaceutical processes, namely, filtration systems for bioprocessing. Installation and maintenance of process intensification systems for biopharmaceutical production.

31.

DEVICE ASSEMBLY WITH A SIGNALLING MEANS

      
Numéro d'application 18810760
Statut En instance
Date de dépôt 2024-08-21
Date de la première publication 2025-03-06
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Grimm, Christian
  • Scholz, Jochen
  • Bode, Matthias

Abrégé

A device assembly including a single-use device for sensing or influencing a parameter of a running bioprocess. The single-use device is configured to have at least two different defined functional states, a first functional state being an inactive delivery state in which the single-use device is sterile and inoperable according to its intended use, and a second functional state being an active use state in which the single-use device is operable according to its intended use. The device assembly further includes a signalling element for indicating a current functional state of the single-use device to a user. Each functional state is associated with a distinct signal. The device assembly is configured such that a transfer from the first functional state to any other functional state of the single-use device is irreversible and/or permanently prevents the signalling element from indicating the signal associated with the first functional state.

Classes IPC  ?

  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies

32.

METHOD OF HARVESTING CELL BROTH, AND MIXING DEVICE

      
Numéro d'application EP2024073641
Numéro de publication 2025/045749
Statut Délivré - en vigueur
Date de dépôt 2024-08-23
Date de publication 2025-03-06
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Heuer, Dennis
  • Leupold, Marco
  • Gao, Wei
  • Wolff, Alexander

Abrégé

A method of harvesting cell broth (12) from a mixing device (10) for mixing the cell broth (12) of a rocking motion bioreactor is shown. The mixing device (10) comprises a rocking motion platform (14), a mixing bag (18) and a processing unit (22). After a harvest process is started, the mixing bag (18) is tilted into a default harvest position and the cell broth (12) is harvested in the default harvest position of the mixing bag (18). If a pause condition is fulfilled, harvesting is paused and the mixing device starts rocking at a defined speed and a defined rocking angle for a predetermined time. After the predetermined time, harvesting in the default harvest position is resumed. Furthermore, a mixing device (10) for mixing cell broth (12) is disclosed.

Classes IPC  ?

  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
  • B01F 27/80 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins avec des agitateurs tournant autour d'un axe sensiblement vertical

33.

METHOD FOR OPERATING A CLARIFICATION SETUP

      
Numéro d'application 18728303
Statut En instance
Date de dépôt 2023-01-11
Date de la première publication 2025-02-20
Propriétaire Sartorius Stedim North America Inc. (USA)
Inventeur(s)
  • Soeldner, Robert
  • Austerjost, Jonas

Abrégé

A method for operating a clarification setup of a bioprocess installation, which clarification setup comprises a fluidized bed centrifuge and a pumping arrangement, wherein the fluidized bed centrifuge comprises at least one centrifuge chamber turned around a geometrical centrifuge axis, wherein the bioprocess installation comprises an electronic process control for controlling the fluidized bed centrifuge and pumping arrangement, wherein the fluidized bed centrifuge is being operated in a forward operation for a particle loading cycle and/or a particle washing cycle and in a backward operation for a particle discharging cycle, wherein in case where a particle loading cycle is provided, cell broth loaded into the centrifuge chamber proceeds to form a growing particle accumulation in the centrifuge chamber, wherein the clarification setup comprises a monitoring sensor arrangement with at least one optical sensor for producing monitoring sensor data, which are being transmitted to the electronic process control.

Classes IPC  ?

  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/26 - Inoculateur ou échantillonneur
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies

34.

METHOD FOR OPERATING A CLARIFICATION SETUP

      
Numéro d'application 18728329
Statut En instance
Date de dépôt 2023-01-11
Date de la première publication 2025-02-20
Propriétaire Sartorius Stedim North America Inc. (USA)
Inventeur(s)
  • Soeldner, Robert
  • Austerjost, Jonas
  • Saballus, Martin

Abrégé

A method for operating a clarification setup, wherein the clarification setup comprises a fluidized bed centrifuge, wherein the fluidized bed centrifuge comprises at least two centrifuge chambers, wherein the fluidized bed centrifuge is being operated in a forward operation for a particle loading cycle and/or a particle washing cycle and in a backward operation for a particle discharging cycle wherein the clarification setup comprises a monitoring sensor arrangement with at least one sensor for producing monitoring sensor data, which are being transmitted to the electronic process control. In a monitoring routine, monitoring sensor data are being produced individually by the monitoring sensor arrangement and that during the loading cycle, in an adjusting routine, at least one parameter of the clarification setup is being adjusted based on the monitoring sensor data as to control the loading of the cell broth the centrifuge chambers individually according to a predefined adjusting strategy.

Classes IPC  ?

  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/26 - Inoculateur ou échantillonneur
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies

35.

METHOD OF CONTROLLING A BIOPHARMACEUTICAL PURIFICATION PROCESS

      
Numéro d'application EP2024067986
Numéro de publication 2025/026621
Statut Délivré - en vigueur
Date de dépôt 2024-06-26
Date de publication 2025-02-06
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Kruse, Thomas
  • Austerjost, Jonas
  • Hoehse, Marek
  • Santos De Matos Fortuna, Ana Raquel
  • Grimm, Christian
  • Surowiec, Izabella

Abrégé

A method of controlling a biopharmaceutical purification process, preferably a continuous process, making use of a separation arrangement. The separation arrangement preferably includes multiple chromatography columns or filtration devices. The method comprises the following steps: repeatedly acquiring an absorption spectrum inline or online at a fluid stream with a detector which is capable of recording spectra within a wavelength range between 190 nm and 2400 nm, preferably between 190 nm and 390 nm or 190 nm and 780 nm or 1100 nm and 2400 nm; real-time processing of the acquired spectrum; and real- time monitoring and controlling the process based on the processed spectrum. The step of processing includes at least one of the following measures: reducing noise; reducing spectral interference; correcting the acquired spectrum for scattering effects and/or other background effects.

Classes IPC  ?

  • G01N 30/74 - Détecteurs optiques
  • G01N 30/86 - Analyse des signaux
  • G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
  • B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement

36.

ON-LINE BIOMOLECULAR ANALYSIS FOR MONITORING OR CONTROLLING BIOPROCESSES

      
Numéro d'application 18696619
Statut En instance
Date de dépôt 2022-09-28
Date de la première publication 2025-01-30
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Scholz, Jochen
  • Grimm, Christian
  • Durous, Laurent
  • Piel, Michael
  • Traenkle, Jens

Abrégé

The disclosure relates to monitoring or controlling bioprocesses by way of withdrawing discrete fluid samples from a reactor and performing on-line analysis of said sample using a fluidic manifold, for example, by way of a sensor based on label-free biomolecular interaction analysis. The disclosure relates to a system for measuring one or more analytes in discrete fluid samples from a vessel adapted to contain a fluid having one or more sensors for the measurement of the analytes in a contact volume of the fluid sample. An analysis module having at least one main sampling line in fluidic connection with the vessel and one or more pumps in fluidic connection with said main sampling line(s) and adapted to selectively pump fluid from in the main sampling line away from the vessel. At least one fluid distribution tubing in fluidic connection with the analysis module. A manifold has a body.

Classes IPC  ?

  • C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement

37.

SOLOHILL

      
Numéro d'application 238572800
Statut En instance
Date de dépôt 2025-01-30
Propriétaire Sartorius Stedim North America Inc. (USA)
Classes de Nice  ? 01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture

Produits et services

(1) Microcarriers for use in manufacturing, laboratory use, and research use; protein-coated microcarrier beads for use in manufacturing, laboratory use, and research use; non-protein coated microcarrier beads for use in manufacturing, laboratory use, and research use; microcarriers for use in preparing cell cultures and in cell culture applications; kits consisting of microcarriers for use in manufacturing, laboratory use, and research use; sterilized bags containing microcarriers for use in manufacturing, laboratory use, and research use.

38.

METHOD AND DEVICE FOR AUTOMATING THE FOAM CONTROL IN A BIOREACTOR

      
Numéro d'application EP2024070626
Numéro de publication 2025/021715
Statut Délivré - en vigueur
Date de dépôt 2024-07-19
Date de publication 2025-01-30
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Kues, Dominic
  • Leupold, Marco

Abrégé

The invention relates to a method for automating the foam regulation during a bioprocess for cultivating cells in a bioreactor, said method comprising the following steps: determining values of one or more process variables of the bioprocess which is/are relevant for the formation of foam in the bioreactor; transferring the determined values as input signals to a controller; generating, by the controller, output signals for at least one foam regulation device depending on the input signals; and controlling the at least one foam regulation device in a requirements-oriented manner by means of the output signals output by the controller.

Classes IPC  ?

  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/21 - Moyens pour supprimer l'écume
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement

39.

COUPLING DEVICE FOR COUPLING TO A DIAPHRAGM DEVICE, DIAPHRAGM DEVICE AND METHOD

      
Numéro d'application EP2024069224
Numéro de publication 2025/012220
Statut Délivré - en vigueur
Date de dépôt 2024-07-08
Date de publication 2025-01-16
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Schenke, Tim
  • Frankenberg, Christoph
  • Lu, Yi-Yao
  • Friedewald, Jürgen

Abrégé

A coupling device (1) for coupling to a flexible diaphragm (51) of a diaphragm device (50) and comprising a base structure (10) for attaching the diaphragm device (50) thereto; an actuator structure (20) mounted movable along an actuation direction (A) relative to the base structure (10) and having a diaphragm grasping element (22) pivotably mounted between a release position and a grasping position for coupling the actuator structure (20) to the flexible diaphragm (51) in the grasping position; and a fixation structure (30) mounted movable along a fixation direction (F) relative to the base structure (10) between an open position and a closed position and designed to fix in the closed position the diaphragm grasping element (22) against leaving the grasping position.

Classes IPC  ?

  • F16K 1/48 - Fixation des corps de soupapes aux tiges des soupapes
  • F16K 7/16 - Dispositifs d'obturation à diaphragme, p. ex. dont un élément est déformé, sans être déplacé entièrement, pour fermer l'ouverture à diaphragme plat, en forme d'assiette ou en forme de bol disposé pour être déformé contre un siège plat le diaphragme étant actionné mécaniquement, p. ex. par une tige filetée ou par came
  • F16L 37/127 - Accouplements du type à action rapide dans lesquels l'assemblage entre les extrémités s'aboutant ou se chevauchant est maintenu par des organes de blocage utilisant des crochets, cliquet, ou autres organes de blocage mobiles ou que l'on peut insérer utilisant des crochets articulés autour d'un axe

40.

System for Simultaneous Distribution of Fluid to Multiple Vessels and Method of Using the Same

      
Numéro d'application 18887188
Statut En instance
Date de dépôt 2024-09-17
Date de la première publication 2025-01-09
Propriétaire Sartorius Stedim North America Inc. (USA)
Inventeur(s)
  • Zumbrum, Michael A.
  • Perdue, Kevin M.
  • Kimmick, William
  • Neuhaus, Jan

Abrégé

A fluid distribution system includes an input tube, a plurality of vessels, and a distribution hub. The input tube is configured to extend from a supply vessel. Each vessel of the plurality of vessels includes an inflow conduit. The distribution hub includes a single inlet and a plurality of outlets. The single inlet is defined in a bottom of the distribution hub and is in fluid communication with the input tube such that the distribution hub is configured to receive fluid from the input tube through the single inlet. Each outlet of the plurality of outlets is in fluid communication with the single inlet and in fluid communication with a respective inflow conduit such that the distribution hub is configured to provide an equal portion of the fluid received through the single inlet to each of the inflow conduits.

Classes IPC  ?

  • B67D 7/02 - Appareils ou dispositifs pour transférer des liquides à partir de récipients ou de réservoirs de stockage en vrac vers des véhicules ou des récipients portables, p. ex. pour la vente au détail pour transférer des liquides autres que des carburants ou des lubrifiants
  • B67D 7/38 - Aménagements des tuyaux flexibles, p. ex. de la liaison de pilotage d'une moto-pompe
  • B67D 7/58 - Aménagements des pompes

41.

MEMBRANE FOR MICROBIOLOGICAL ANALYSIS

      
Numéro d'application 18710577
Statut En instance
Date de dépôt 2022-11-15
Date de la première publication 2025-01-09
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Ernst, Andrea
  • Rüngeling, Elke
  • Gniewosz, Bastian
  • Mazurek-Swidereck, Katharina
  • Wagner, Niels

Abrégé

A membrane for microbiological analysis, a production method of a membrane for microbiological analysis, and the use of such membranes for microbiological analysis. Examples include a cellulose membrane for microbiological analysis that is impregnated with a non-ionic surfactant in an amount of from 100 ng/cm2 to 1.0 mg/cm2, with the membrane having a nominal pore size of from 0.20 μm to 0.80 μm, and a cumulative adsorption pore volume of less than 0.010 cm3/g.

Classes IPC  ?

  • C12Q 1/06 - Détermination quantitative
  • B01D 61/14 - UltrafiltrationMicrofiltration
  • B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
  • B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
  • B01D 71/10 - CelluloseCellulose modifiée

42.

Composite Articles of Lattice Reinforced Elastomers

      
Numéro d'application 18894621
Statut En instance
Date de dépôt 2024-09-24
Date de la première publication 2025-01-09
Propriétaire Sartorius Stedim North America Inc. (USA)
Inventeur(s)
  • Zumbrum, Michael
  • Kimmick, William
  • Perdue, Kevin

Abrégé

A composite article includes a lattice and an elastomeric section. The lattice includes a plurality of members that form an open-mesh frame defining a plurality of voids between the adjacent members of the frame. The elastomeric section is formed of an elastomer that is disposed about the lattice and within the voids of the lattice. The composite article may be a circular gasket, a gasket with a grip, a rectangular gasket, a vessel cap, a flask stand, and a handle for a hand tool.

Classes IPC  ?

  • B65D 41/00 - Capuchons, p. ex. couvercles à rebords ou capsules à sertissage, c.-à-d. éléments ayant des parties prenant sur la périphérie extérieure d'un col ou d'une paroi limitant une ouverture de versement ou de déchargeCouvercles de protection en forme de capuchons pour les éléments de fermeture, p. ex. couvercles décoratifs en feuille de métal ou en papier
  • B01L 9/00 - Dispositifs de supportDispositifs de serrage
  • B25G 1/10 - Fabrication des manches caractérisés par le matériau ou la forme
  • B29C 45/14 - Moulage par injection, c.-à-d. en forçant un volume déterminé de matière à mouler par une buse d'injection dans un moule ferméAppareils à cet effet en incorporant des parties ou des couches préformées, p. ex. moulage par injection autour d'inserts ou sur des objets à recouvrir
  • B33Y 80/00 - Produits obtenus par fabrication additive
  • F16J 15/02 - Joints d'étanchéité entre surfaces immobiles entre elles

43.

Sartobind Convec

      
Numéro d'application 1831852
Statut Enregistrée
Date de dépôt 2024-08-20
Date d'enregistrement 2024-08-20
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 07 - Machines et machines-outils
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement
  • 17 - Produits en caoutchouc ou en matières plastiques; matières à calfeutrer et à isoler

Produits et services

Filter modules, namely filter capsules, filter candles, filter cassettes, coil modules, filter coils, filter coils in connection with filter centrifuges, band filters, small filters, small filters in connection with centrifuge tubes and as centrifugal concentrators, disposable filters; membrane filters and filter matting being parts of machines, for use in biotechnology, environmental protection, for the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and for use in genetic engineering, medicine and in laboratories, and for treatment and analysis of water and effluent; filters being parts of machines; membrane filters for use as part of machines. Laboratory filters; filtering units for laboratory use; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors sold as a set for laboratory use; membranes for filtration (laboratory use); filters for use with laboratory chromatography apparatus; membrane filters and filter matting for laboratories with adsorption properties, membrane adsorbers, namely adsorption membranes, ion exchange membranes, ligand membranes and activated membranes in the form of hollow fibre membranes, tube membranes and flat membranes as strips or cut to size for use in apparatus, filters and filter modules for the aforesaid fields of application; membrane filters and filter matting as parts of microtitre plates; membrane filters and filter matting as parts of diagnostic tests such as diagnostic assays and immunoassays; membrane filters and filter matting as parts of filter systems or as independent filters for chromatographic analyses and chemical separation, reconcentration, for sterilisation and ultrapurification of fluids; filters and filter modules for filtering and reconcentration of biological solutions, namely of viral and bacterial suspensions; filters and filter modules for treating blood and other bodily fluids. Air filters and filtering units, for industrial use; liquid filters and filtering units, for industrial use; filters for filtering fluids, filter modules, filter candles and filter capsules; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors, sold as a set, for industrial installations; filters for water filtering apparatus; cartridge filtration units [water treatment equipment]; filters for use with industrial chromatography apparatus; apparatus for water treatment and for preparing solutions in the pharmaceutical, medical and laboratory fields; equipment for de-ionising water; equipment for de-pyrogenisation of solutions and for separating harmful substances from fluids; filters and filter modules for desalination of protein solutions and other biological media; filters and filter modules for analysis and separation of ions, macromolecules and biomolecules, namely carbohydrates, peptides, proteins and nucleic acids and for separating heavy metals and harmful substances from fluids; filters for industrial use, namely, membrane filters and filter matting having applications in biotechnology, environmental protection, the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and in genetic engineering, medicine and laboratories, and the treatment and analysis of water and effluents. Membranes and semi-processed synthetic filtering materials; polymeric membranes; polymeric porous membranes in hollow fibre form; polymeric porous membranes in sheet form; transfer membranes of cellulose derivatives; transfer membranes of cellulose; transfer membranes of polyamides; transfer membranes of polyvinylidene fluoride; cross-linked polymeric membranes in sheet form; cross-linked polymeric membranes in hollow fibre form.

44.

METHOD FOR PERFORMING A TANGENTIAL FLOW FILTRATION ON A BIOMOLECULAR SOLUTION

      
Numéro d'application EP2024067226
Numéro de publication 2025/002968
Statut Délivré - en vigueur
Date de dépôt 2024-06-20
Date de publication 2025-01-02
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Stark, Oliver
  • Aissa, Tarek
  • Helling, Alexander

Abrégé

The invention relates to a method for performing a tangential flow filtration on a biomolecular solution, in particular for performing a single pass tangential flow filtration on a biomolecular solution, as part of a production process for biomolecules, wherein a tangential flow filtration arrangement (1) is provided, wherein the tangential flow filtration arrangement (1) comprises a tangential flow filtration module (2), wherein the tangential flow filtration is performed inside the tangential flow filtration module (2), wherein the tangential flow filtration module (2) comprises a filter (3), a feed input fluid line (4) for the biomolecular solution as a feed medium, a retentate output fluid line (6) for a retentate, a filtrate output fluid line (7) for a filtrate, and preferably a buffer input fluid line (5) for a buffer, wherein the tangential flow filtration arrangement (1) comprises at least two actuators (8) influencing the tangential flow filtration, wherein the tangential flow filtration arrangement (1) comprises a control module (10), wherein the control module (10) controls the tangential flow filtration by providing control signals to the actuators (8) and measuring at least two measured variables (11) describing the tangential flow filtration, wherein the control module (10) uses a process control to control the tangential flow filtration. It is proposed that the process control is a model predictive control (13), that the control module (10) inputs the measured variables (11) as input variables (14) into the model and derives at least two manipulated variables (15) as control signals for the actuators (8).

Classes IPC  ?

45.

DEVICE FOR CONTINUOUS VIRUS INACTIVATION

      
Numéro d'application EP2024067792
Numéro de publication 2025/003126
Statut Délivré - en vigueur
Date de dépôt 2024-06-25
Date de publication 2025-01-02
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s) Deuse, Mario

Abrégé

The invention relates to a device for continuous virus inactivation during a protein production process, in particular an antibody production process, wherein the device comprises an axially extending hollow-body holder (1) for holding an elongated, elastically deformable hollow body (2), in particular a flexible tube, wherein the device comprises at least two axially extending rollers (3, 4), in particular three or four rollers (3, 4, 5, 6), each of which, when the device has been assembled as intended, squeezes the hollow body (2) and thereby divides the internal volume (7) of the hollow body (2) into volume portions (8) fluidically separated from one another, wherein the continuous virus inactivation is carried out in the volume portions (8) of the hollow body (2). It is proposed that the device comprises a support element (9) which, when the device has been assembled as intended, supports the lateral faces of each of the rollers (3, 4, 5, 6) in at least one point.

Classes IPC  ?

  • C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
  • A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
  • C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • B01D 15/24 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au traitement des fractions à répartir

46.

METHOD OF OPERATING A BIOPROCESSING ARRANGEMENT COMPRISING A CLARIFICATION SET-UP TO REMOVE CELL DEBRIS FROM A CELL BROTH

      
Numéro d'application EP2024067278
Numéro de publication 2024/261145
Statut Délivré - en vigueur
Date de dépôt 2024-06-20
Date de publication 2024-12-26
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Saballus, Martin
  • Reger, Lucas Nik
  • Kampmann, Markus
  • Niemann, Julia

Abrégé

The invention relates to a method of operating a bioprocessing arrangement (1) comprising a clarification set-up (2) to remove cell debris from a cell broth (10), wherein the clarification set-up (2) comprises a fluidized bed centrifuge (8) with at least one centrifuge chamber (11), wherein the cell broth (10) is separated into at least a waste fraction (12) and an output fraction (13), wherein the separation of the cell broth (10) into the waste fraction (12) and the output fraction (13) comprises a loading step (14) during which the centrifuge chamber (11) is loaded with cells of the cell broth (10) up to a capacity below or equal to a maximum cell loading capacity of the centrifuge chamber (11), an overloading step (15) during which the centrifuge chamber (11) is further loaded with cell broth (10), thereby flushing out cells from the centrifuge chamber (11), collecting cells flushed out during the overloading step (15) as the waste fraction (12), and collecting cells from the chamber as the output fraction (13).

Classes IPC  ?

  • C12M 1/26 - Inoculateur ou échantillonneur
  • B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p. ex. butyromètres
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12N 1/02 - Séparation des micro-organismes de leurs milieux de culture

47.

Sartopore Evo

      
Numéro d'application 1829381
Statut Enregistrée
Date de dépôt 2024-10-10
Date d'enregistrement 2024-10-10
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement

Produits et services

Laboratory filters; filtration membranes for laboratory use; laboratory filtration apparatus and filtering materials for the filtration of liquids and gases; filters, for use in relation to the following goods: laboratory apparatus in the biopharmaceutical industry; filtration systems, devices, and membranes for laboratory use. Filters for industrial use, namely for liquids, gases, and biopharmaceutical applications; filtration units; filtration units, namely filter cartridges, filter capsules, filter modules, filter capsules and disposable filters, for industrial purposes; filters, namely small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries.

48.

SEPARATION SYSTEM AND METHOD FOR SEPARATING AND PURIFYING A TARGET COMPONENT

      
Numéro d'application 18700457
Statut En instance
Date de dépôt 2022-10-13
Date de la première publication 2024-12-12
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Kruse, Thomas
  • Kampmann, Markus
  • Helling, Alexander
  • Leuthold, Martin

Abrégé

A separation system for separating and purifying a target component, a method for separating and purifying a target component, and the use of a crossflow diafiltration unit for processing a target phase. The system includes an aqueous-two phase extraction unit for aqueous-two phase extraction of the fluid, a separation unit for separating a target phase, and a crossflow diafiltration unit.

Classes IPC  ?

  • B01D 11/04 - Extraction par solvants de solutions
  • B01D 17/02 - Séparation de liquides non miscibles
  • B01D 61/16 - Prétraitement du courant d'alimentation
  • C07K 1/14 - ExtractionSéparationPurification
  • C07K 1/34 - ExtractionSéparationPurification par filtration, ultrafiltration ou osmose inverse

49.

SMART BIOPROCESS TUBE LINE ASSEMBLY

      
Numéro d'application 18695889
Statut En instance
Date de dépôt 2022-09-27
Date de la première publication 2024-12-05
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s) Grimm, Christian

Abrégé

A smart single-use tube line assembly for use in a unit operation of a bioprocess including at least one tube line. The tube line includes a tube body surrounding a lumen through which a medium can flow. The tube line assembly also includes a functional element embedded in the tube body, the functional element being configured to perform an optical and/or electrical function. The tube line assembly further includes an interface for coupling both the lumen and the functional element of the tube line to another component. The tube line assembly still further includes a control unit for controlling the optical and/or electrical function.

Classes IPC  ?

  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement

50.

AERATION DEVICE FOR A BIOPROCESSING INSTALLATION

      
Numéro d'application EP2024063441
Numéro de publication 2024/245760
Statut Délivré - en vigueur
Date de dépôt 2024-05-15
Date de publication 2024-12-05
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Adams, Thorsten
  • Kukla, Clint
  • Mercelat, Aurore
  • Leopold, Marco
  • Greller, Gerhard
  • Husemann, Ute
  • Sutthasinwong, Kanin
  • Prochaska, Charles

Abrégé

The invention relates to a an aeration device for a bioprocessing installation (2), comprising a housing (4), a circumferential rigid body (5), wherein the housing (4) comprises at least a first aeration channel (7) and a second aeration channel (8), wherein the housing (4) further comprises at least a first gas inlet port (10) and a second gas inlet port (11), and wherein the housing (4) further comprises a plurality of first gas discharge openings (12) and second gas discharge openings (13). It is proposed that the first aeration channel (7) and the second aeration channel (8) are arranged so as to overlap one another in the axial direction at least in sections.

Classes IPC  ?

  • B01F 23/231 - Mélange de gaz avec des liquides en introduisant des gaz dans des milieux liquides, p. ex. pour produire des liquides aérés par barbotage
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

51.

CLAMPING DEVICE FOR CONNECTING HOSE BARBS

      
Numéro d'application 18647006
Statut En instance
Date de dépôt 2024-04-26
Date de la première publication 2024-10-31
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Prediger, Andreas
  • Schenke, Tim

Abrégé

A clamping device for fluidically and mechanically connecting two hose barbs. The clamping device includes a seal and a locking mechanism, wherein the locking mechanism can be transferred from a mounting condition to an assembled condition. In the mounting condition, the hose barbs can be inserted into the clamping device, while in the assembled condition, those hose barbs are locked in place in a position in which free ends of the hose barbs face each other and a seal coaxially aligns and fluid-tightly connects the free ends.

Classes IPC  ?

  • F16L 33/22 - Dispositions d'assemblage des manches avec des organes rigidesRaccords rigides pour manches, p. ex. éléments unitaires s'engageant à la fois dans deux manches avec moyens non mentionnés dans les groupes précédents pour saisir la manche entre l'extérieur et l'intérieur
  • F16L 33/18 - Dispositions d'assemblage des manches avec des organes rigidesRaccords rigides pour manches, p. ex. éléments unitaires s'engageant à la fois dans deux manches caractérisées par l'emploi de moyens d'étanchéité additionnels

52.

FILTRATION DEVICE, IN PARTICULAR SMALL-SCALE FILTRATION DEVICE FOR PRODUCTION OF BIOPHARMACEUTICALS

      
Numéro d'application EP2024061675
Numéro de publication 2024/223903
Statut Délivré - en vigueur
Date de dépôt 2024-04-26
Date de publication 2024-10-31
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Friese, Thomas
  • Grell, Gerid
  • Rüsch, Natalie
  • Dorfschäfer, Philipp
  • Löwe, Thomas

Abrégé

A filtration device (10), in particular a small-scale filtration device for production of biopharmaceuticals, comprises a housing including a top cover (12) having an unfiltrate inlet (18) and a bottom cover (14) having a filtrate outlet (22), and one or more filter supports (16) stacked between the top cover (12) and the bottom cover (14) along a vertical direction such that an upper side of each filter support (16) faces the top cover (12) and a lower side of each filter support (16) faces the bottom cover (14). Each filter support (16) is equipped with a flat upper filter (40) and a flat lower filter (42). Each filter (40, 42) has a filtrate side and an opposite unfiltrate side. The upper and lower filters (40, 42) are sealed to the upper and lower sides of the filter support (16), respectively, with the filtrate sides facing the filter support (16) and the unfiltrate sides facing away from the filter support (16). Unfiltrate flow paths lead from the unfiltrate inlet of the top cover (12) to the unfiltrate side of the upper filter (40) and to the unfiltrate side of the lower filter (42), wherein blocking means prevent unfiltrate from flowing directly from the unfiltrate inlet of the top cover (12) to the filtrate outlet (22) of the bottom cover (14). Filtrate flow paths lead from the filtrate sides of the upper and lower filters (40, 42) to the filtrate outlet (22) of the bottom cover (14) via at least one filtrate guiding channel (48a, 48b) formed on the upper side of the filter support (16) and at least one filtrate guiding channel (48a, 48b) formed on the lower side of the filter support (16). The upper filter (40) and the lower filter (42) are identically shaped.

Classes IPC  ?

  • B01D 63/08 - Modules à membranes planes
  • C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
  • B01D 69/10 - Membranes sur supportSupports pour membranes
  • B01D 25/26 - Filtres empilés du type à cellules
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

53.

TUBE HOLDING APPARATUSES FOR FILLING OF MULTIPLE CONTAINERS AND METHODS FOR USING THE SAME

      
Numéro d'application 18545316
Statut En instance
Date de dépôt 2023-12-19
Date de la première publication 2024-10-24
Propriétaire Sartorius Stedim North America Ins. (USA)
Inventeur(s)
  • Boissières, Karine Vizcaino
  • Hojeij, Ali
  • Rethore, Amélie
  • Cardace, Timothy
  • Shamin, Aleksander
  • Keenan, Meghan

Abrégé

A tube holding apparatus includes a body, a mount, a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.

Classes IPC  ?

  • B67C 3/26 - Têtes de remplissageDispositifs pour introduire les têtes de remplissage dans les goulots des bouteilles
  • B65B 37/02 - Approvisionnement ou alimentation des matériaux solides fluents, plastiques ou liquides, ou de masses en vrac, de petits objets, à emballer par pesanteur

54.

TUBE HOLDING APPARATUSES FOR FILLING OF MULTIPLE CONTAINERS AND METHODS FOR USING THE SAME

      
Numéro d'application IB2024053800
Numéro de publication 2024/218711
Statut Délivré - en vigueur
Date de dépôt 2024-04-18
Date de publication 2024-10-24
Propriétaire SARTORIUS STEDIM NORTH AMERICA INC. (USA)
Inventeur(s)
  • Boissiéres, Karine Vizcaino
  • Hojeij, Ali
  • Rethore, Amélie
  • Cardace, Timothy
  • Shamin, Aleksander
  • Keenan, Meghan

Abrégé

A tube holding apparatus includes a body, a mount a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.

Classes IPC  ?

  • B65B 3/00 - Emballage de matériaux plastiques, de semi-liquides, de liquides ou de liquides et solides mélangés, dans des réceptacles ou récipients individuels, p. ex. dans des sacs ou sachets, boîtes, cartons, bidons ou pots
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

55.

Tube holding apparatuses for filling of multiple containers and methods for using the same

      
Numéro d'application 18617230
Numéro de brevet 12252386
Statut Délivré - en vigueur
Date de dépôt 2024-03-26
Date de la première publication 2024-10-24
Date d'octroi 2025-03-18
Propriétaire Sartorius Stedim North America Inc. (USA)
Inventeur(s)
  • Boissières, Karine Vizcaino
  • Hojeij, Ali
  • Rethore, Amélie
  • Cardace, Timothy
  • Shamin, Aleksander
  • Keenan, Meghan

Abrégé

A tube holding apparatus includes a body, a mount, a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.

Classes IPC  ?

  • B67C 3/26 - Têtes de remplissageDispositifs pour introduire les têtes de remplissage dans les goulots des bouteilles
  • B65B 37/02 - Approvisionnement ou alimentation des matériaux solides fluents, plastiques ou liquides, ou de masses en vrac, de petits objets, à emballer par pesanteur

56.

SARTOPORE EVO

      
Numéro de série 79412737
Statut En instance
Date de dépôt 2024-10-10
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement

Produits et services

Laboratory filters; filtration membranes for laboratory use; laboratory filtration apparatus and filtering materials for the filtration of liquids and gases; filters, for use in relation to the following goods: laboratory apparatus in the biopharmaceutical industry; filtration systems, devices, and membranes for laboratory use. Filters for industrial use, namely for liquids, gases, and biopharmaceutical applications; filtration units; filtration units, namely filter cartridges, filter capsules, filter modules, filter capsules and disposable filters, for industrial purposes; filters, namely small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries.

57.

Sartopore Evo

      
Numéro d'application 236955000
Statut En instance
Date de dépôt 2024-10-10
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement

Produits et services

(1) Laboratory filters; filtration membranes for laboratory use; laboratory filtration apparatus and filtering materials for the filtration of liquids and gases; filters, for use in relation to the following goods: laboratory apparatus in the biopharmaceutical industry; filtration systems, devices, and membranes for laboratory use. (2) Filters for industrial use, namely for liquids, gases, and biopharmaceutical applications; filtration units; filtration units, namely filter cartridges, filter capsules, filter modules, filter capsules and disposable filters, for industrial purposes; filters, namely small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries.

58.

METHOD AND SYSTEM FOR TESTING THE INTEGRITY OF FILTERS

      
Numéro d'application 18259258
Statut En instance
Date de dépôt 2021-12-23
Date de la première publication 2024-09-26
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s) Chatterjee, Kirit

Abrégé

A method for testing integrity of a filter can include pressurizing an upstream side of the filter to a test pressure and performing a check step that includes determining a flow rate of fluid from the upstream side to a downstream side of the filter, comparing the determined flow rate with a flow range including a flow threshold, and setting stop criteria based on the comparison.

Classes IPC  ?

  • G01N 15/08 - Recherche de la perméabilité, du volume des pores ou de l'aire superficielle des matériaux poreux

59.

FABRICATION OF MEMBRANES VIA COMBINED EVAPORATION- AND PRECIPITANT-INDUCED PHASE SEPARATION

      
Numéro d'application EP2024057785
Numéro de publication 2024/194464
Statut Délivré - en vigueur
Date de dépôt 2024-03-22
Date de publication 2024-09-26
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Schleuss, Tobias
  • Van Der Kruijs, Sandra
  • Warnke, Catharina
  • Schwellenbach, Jan

Abrégé

The present invention relates to an ultrafiltration membrane and to a method for producing the same.

Classes IPC  ?

  • B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
  • B01D 71/16 - Acétate de cellulose
  • B01D 71/68 - PolysulfonesPolyéthersulfones

60.

THERMAL TREATMENT OF ULTRAFILTRATION MEMBRANES

      
Numéro d'application EP2024057787
Numéro de publication 2024/194465
Statut Délivré - en vigueur
Date de dépôt 2024-03-22
Date de publication 2024-09-26
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s) Schleuss, Tobias

Abrégé

The present invention relates to a method for treating an ultrafiltration membrane, a method for producing an ultrafiltration membrane comprising the treatment method, as well as ultrafiltration membrane obtained by the treatment method or the production method.

Classes IPC  ?

  • B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
  • B01D 71/14 - Esters d'acides organiques
  • B01D 71/22 - Éthers cellulosiques
  • B01D 61/14 - UltrafiltrationMicrofiltration

61.

MODULAR PROCESSING SYSTEM AND METHOD FOR THE MODULAR CONSTRUCTION OF A PROCESSING SYSTEM

      
Numéro d'application 18673916
Statut En instance
Date de dépôt 2024-05-24
Date de la première publication 2024-09-19
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Leuthold, Martin
  • Weisshaar, Stefan

Abrégé

A modular processing system (100) for biopharmaceutical processes includes (i) at least one first and at least one second processing unit (30, 32), which can be fluidically connected to each other; and (ii) at least one adapter plate (200), through which at least one fluid flow (14), flowing from the first processing unit (30) to the second processing unit (32), can flow. The adapter plate deflects the fluid flow between the first processing unit and the second processing unit at least partially; and/or controls the fluid flow, preferably, the pressure thereof, in an open loop or closed loop manner. A method for the modular construction of a processing system (100) for biopharmaceutical processes is also disclosed.

Classes IPC  ?

  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • B01D 65/02 - Nettoyage ou stérilisation de membranes
  • C07K 1/36 - ExtractionSéparationPurification par une combinaison de plusieurs procédés de types différents
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
  • C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus

62.

Pionic

      
Numéro d'application 019080859
Statut Enregistrée
Date de dépôt 2024-09-18
Date d'enregistrement 2025-04-23
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
  • 07 - Machines et machines-outils
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement
  • 37 - Services de construction; extraction minière; installation et réparation

Produits et services

Chemicals and reagents for use in media and buffer preparation, seed train, filtration, chromatography, and virus clearance in biotechnology and biopharmaceutical industries; Chemicals for industrial and laboratory use in biopharmaceutical processing, including those for filtration and purification of biological materials. Machinery and automated equipment for media and buffer preparation, seed train, filtration, chromatography, and polishing; Industrial robots and apparatus for bioprocessing and manufacturing including filtration systems for the purification and separation of biological substances. Scientific, research, and laboratory apparatus for use in biopharmaceutical manufacturing, namely, apparatus for media and buffer preparation, seed train and production, filtration, chromatography, polishing and virus clearance; Downloadable and recorded software for biopharmaceutical processes, namely, software for media preparation, buffer preparation, seed train optimization, filtration, chromatography, polishing, and virus clearance; Control systems and software for automating biopharmaceutical processes, namely, software for filtration and purification processes; Interfaces and human-machine interface (HMI) software for managing and optimizing biopharmaceutical processes; Data collection and management software for process intensification systems; Devices for real-time monitoring and optimization for biopharmaceutical production. Industrial filtration apparatus for water, air, and gas purification; Chromatography apparatus for biopharmaceutical purification; Process systems and equipment for the filtration, purification, and separation of biological substances in biopharmaceutical processes, namely, filtration systems for bioprocessing. Installation and maintenance of process intensification systems for biopharmaceutical production.

63.

Pionic

      
Numéro d'application 019080878
Statut Enregistrée
Date de dépôt 2024-09-18
Date d'enregistrement 2025-02-14
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ? 42 - Services scientifiques, technologiques et industriels, recherche et conception

Produits et services

Scientific and technological research services in the field of biopharmaceuticals, specifically relating to bioprocess optimization, including media and buffer preparation, seed train, filtration, chromatography, and virus clearance; Design and development of computer software for biopharmaceutical process automation and control; Technical consultancy services related to biopharmaceutical process optimization, focusing on bioprocess steps namely, filtration, chromatography, and virus clearance; Software as a service (SaaS) for biopharmaceutical manufacturing, including media and buffer preparation, seed train, filtration, chromatography, polishing and virus clearance; IT-services in relation to cloud-based interfaces for managing biopharmaceutical manufacturing processes, namely, interfaces for filtration, purification, and virus clearance systems; Testing and validation services for bioprocessing equipment and systems; Process scale-up technical consulting and technical support for biopharmaceutical production.

64.

PORTABLE CONTAINER HOLDER FOR USE IN A BIOPROCESS

      
Numéro d'application EP2024053741
Numéro de publication 2024/179843
Statut Délivré - en vigueur
Date de dépôt 2024-02-14
Date de publication 2024-09-06
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s) Hogreve, Marc

Abrégé

The invention relates to a portable container holder for use in a bioprocess for holding and transporting a disposable container (3) which is filled with a fluid (2) and which has received a magnetically driven mixing element (4) for mixing the fluid (2), wherein the portable container holder (1) has a container receiving area (7) for receiving the disposable container (3), said receiving area having a drive location (8) where the mixing element (4) can be arranged in the disposable container (3) received in the container receiving area (7) such that the mixing element (4) can be driven by a drive unit (9) at the drive location (8). According to the invention, the portable container holder (1) has a transport securing unit (11) for securing and releasing the mixing element (4), which is arranged at the drive location (8), in its position, and the transport securing unit (11) has a magnet (10) which can be moved between a defined securing position (12), in which the mixing element (4) is secured in its position, and a defined release position (13), in which the mixing element (4) is released from its position.

Classes IPC  ?

  • B01F 33/453 - Mélangeurs magnétiquesMélangeurs avec agitateurs à entraînement magnétique en utilisant des éléments d'agitation supportés ou suspendus
  • B01F 33/502 - Dispositifs de mélange montés sur véhicule
  • B01F 35/42 - Dispositions de serrage ou de maintien pour le montage des récipients sur les dispositifs de mélange
  • B01F 35/43 - Récipients de soutien sur des cadres ou des supports
  • B01F 35/513 - Récipients souples, p. ex. sacs supportés par des conteneurs rigides

65.

PORTABLE CONTAINER HOLDER FOR USE IN A BIOPROCESS

      
Numéro d'application EP2024053893
Numéro de publication 2024/179850
Statut Délivré - en vigueur
Date de dépôt 2024-02-15
Date de publication 2024-09-06
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s) Hogreve, Marc

Abrégé

The invention relates to a portable container holder for use in a bioprocess for holding and transporting a flexible disposable container (3) which is filled with a fluid (2). In particular, the fluid (2) is a fluid (2) which contains a purified pharmaceutical ingredient or a cultivation medium, and the portable container holder (1) has a container receiving area (6) for receiving the disposable container (3) and a cover (7) which can be installed on the container receiving area (6) in order to cover (7) the disposable container (3) received in the container receiving area (6), wherein the cover (7) has a fixing assembly (8) via which the disposable container (3) filled with the fluid (2) can be fixed in the container receiving area (6) in the installed state of the cover (7). According to the invention, the cover (7) has a spring assembly (9) which elastically supports the fixing assembly (8), and a spring force can be applied to the fixing assembly (8) in the direction of the spring via the spring assembly (9) in the installed state of the cover (7).

Classes IPC  ?

  • B01L 9/00 - Dispositifs de supportDispositifs de serrage
  • B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

66.

DEVICE ARRANGEMENT AND METHOD OF SEPARATING CELLS FROM A CULTURE MEDIUM IN A BIOPROCESS

      
Numéro d'application 18569271
Statut En instance
Date de dépôt 2022-06-14
Date de la première publication 2024-08-22
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s) Diel, Bernhard

Abrégé

A device arrangement for separating cells from a culture medium in a bioprocess, in particular in a biopharmaceutical process, including a storage tank for the culture medium; a filtration module having a membrane adapted to be overflowed; an intake line connecting the storage tank to an unfiltrate inlet for supplying culture medium into the filtration module; a return line which connects a retentate-side outlet of the filtration module to the storage tank for returning retentate into the storage tank; a filtrate line which is connected to a permeate-side outlet of the filtration module for discharging filtrate; a first pump for maintaining a recirculation circuit; a backflush line which leads to a permeate-side connection and/or to the permeate-side outlet for supplying a rinsing liquid into the filtration module; and a second pump for conveying the rinsing liquid into the filtration module. A method of separating cells from a culture medium.

Classes IPC  ?

  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse

67.

SARTOBIND CONVEC

      
Numéro de série 79413844
Statut En instance
Date de dépôt 2024-08-20
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 07 - Machines et machines-outils
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement
  • 17 - Produits en caoutchouc ou en matières plastiques; matières à calfeutrer et à isoler

Produits et services

Filter modules, namely filter capsules, filter candles, filter cassettes, coil modules, filter coils, filter coils in connection with filter centrifuges, band filters, small filters, small filters in connection with centrifuge tubes and as centrifugal concentrators, disposable filters; membrane filters and filter matting being parts of machines, for use in biotechnology, environmental protection, for the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and for use in genetic engineering, medicine and in laboratories, and for treatment and analysis of water and effluent; filters being parts of machines; membrane filters for use as part of machines. Laboratory filters; filtering units for laboratory use; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors sold as a set for laboratory use; membranes for filtration (laboratory use); filters for use with laboratory chromatography apparatus; membrane filters and filter matting for laboratories with adsorption properties, membrane adsorbers, namely adsorption membranes, ion exchange membranes, ligand membranes and activated membranes in the form of hollow fibre membranes, tube membranes and flat membranes as strips or cut to size for use in apparatus, filters and filter modules for the aforesaid fields of application; membrane filters and filter matting as parts of microtitre plates; membrane filters and filter matting as parts of diagnostic tests such as diagnostic assays and immunoassays; membrane filters and filter matting as parts of filter systems or as independent filters for chromatographic analyses and chemical separation, reconcentration, for sterilisation and ultrapurification of fluids; filters and filter modules for filtering and reconcentration of biological solutions, namely of viral and bacterial suspensions; filters and filter modules for treating blood and other bodily fluids. Air filters and filtering units, for industrial use; liquid filters and filtering units, for industrial use; filters for filtering fluids, filter modules, filter candles and filter capsules; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors, sold as a set, for industrial installations; filters for water filtering apparatus; cartridge filtration units [water treatment equipment]; filters for use with industrial chromatography apparatus; apparatus for water treatment and for preparing solutions in the pharmaceutical, medical and laboratory fields; equipment for de-ionising water; equipment for de-pyrogenisation of solutions and for separating harmful substances from fluids; filters and filter modules for desalination of protein solutions and other biological media; filters and filter modules for analysis and separation of ions, macromolecules and biomolecules, namely carbohydrates, peptides, proteins and nucleic acids and for separating heavy metals and harmful substances from fluids; filters for industrial use, namely, membrane filters and filter matting having applications in biotechnology, environmental protection, the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and in genetic engineering, medicine and laboratories, and the treatment and analysis of water and effluents. Membranes and semi-processed synthetic filtering materials; polymeric membranes; polymeric porous membranes in hollow fibre form; polymeric porous membranes in sheet form; transfer membranes of cellulose derivatives; transfer membranes of cellulose; transfer membranes of polyamides; transfer membranes of polyvinylidene fluoride; cross-linked polymeric membranes in sheet form; cross-linked polymeric membranes in hollow fibre form.

68.

DIATOMACEOUS EARTH COMPOSITION WITH A LOW ENDOTOXIN CONTENT

      
Numéro d'application 18420145
Statut En instance
Date de dépôt 2024-01-23
Date de la première publication 2024-08-08
Propriétaire Sartorius Stedim Biotech GMBH (Allemagne)
Inventeur(s)
  • Pflanz, Karl
  • Hebenstreit, Florian
  • Pickl, Andreas

Abrégé

The present invention relates to a diatomaceous earth composition with a low endotoxin content, comprising an agglomerated mixture of calcined diatomaceous earth particles and water, wherein the mass ratio of calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the endotoxin content of the diatomaceous earth composition is equal to or less than 0.5 EU/mL. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition with a low endotoxin content. In another aspect, the present invention relates to the use of the diatomaceous earth composition with a low endotoxin content as a precoat agent for the precoat filtration in biopharmaceutical applications.

Classes IPC  ?

  • B01J 20/14 - Terre de diatomée
  • A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
  • B01D 37/02 - Revêtement préalable des éléments filtrants ou de la substance filtranteAddition d'adjuvants de filtration au liquide à filtrer
  • B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
  • B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
  • B65B 55/02 - Stérilisation, p. ex. de paquets finis
  • B65D 65/40 - Emploi de stratifiés pour des buts particuliers d'emballage
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

69.

PRODUCT FOR PROVIDING MEMBRANE ELEMENTS AND MANUFACTURING METHOD

      
Numéro d'application 18566208
Statut En instance
Date de dépôt 2022-05-23
Date de la première publication 2024-08-08
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Kesting, Alfons
  • Sun, Wei
  • Bremerich, Marcel
  • Villain, Louis

Abrégé

The invention relates to a product for providing membrane elements, comprising: a carrier film; and a membrane film, at least comprising: a support layer; and a membrane layer; the membrane film is releasably coupled to the carrier film; and the membrane film has a plurality of substantially discrete membrane elements. The invention also relates to a corresponding manufacturing process.

Classes IPC  ?

  • B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
  • B32B 3/30 - Produits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche continue dont le périmètre de la section droite a une allure particulièreProduits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche comportant des cavités ou des vides internes caractérisés par une couche comportant des retraits ou des saillies, p. ex. des gorges, des nervures
  • B32B 7/06 - Liaison entre couches permettant une séparation sans difficultés
  • B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
  • B32B 23/06 - Produits stratifiés composés essentiellement de substances cellulosiques plastiques comprenant de telles substances comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique de papier ou de carton
  • B32B 23/08 - Produits stratifiés composés essentiellement de substances cellulosiques plastiques comprenant de telles substances comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique de résine synthétique
  • B32B 23/20 - Produits stratifiés composés essentiellement de substances cellulosiques plastiques comprenant des esters
  • B32B 27/08 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique d'une résine synthétique d'une sorte différente
  • B32B 27/10 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique de papier ou de carton
  • B32B 27/28 - Produits stratifiés composés essentiellement de résine synthétique comprenant des copolymères de résines synthétiques non complètement couverts par les sous-groupes suivants
  • B32B 37/12 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par l'usage d'adhésifs
  • B32B 37/18 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par les propriétés des couches toutes les couches existant et présentant une cohésion avant la stratification impliquant uniquement l'assemblage de feuilles ou de panneaux individualisés
  • B32B 38/10 - Enlèvement de couches ou de parties de couches, mécaniquement ou chimiquement

70.

BIOPROCESS SYSTEM FOR A BIOPROCESS OPERATION WITH A DISPLAY ARRANGEMENT FOR DISPLAYING SYSTEM INFORMATION ABOUT THE BIOPROCESS SYSTEM

      
Numéro d'application EP2023084422
Numéro de publication 2024/156414
Statut Délivré - en vigueur
Date de dépôt 2023-12-06
Date de publication 2024-08-02
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Stein, Dominik
  • Kirst, Philipp Werner
  • Reimann, Nils
  • Bluma, Arne

Abrégé

The invention relates to a bioprocess system for a bioprocess operation with a display arrangement (21) for displaying system information about the bioprocess system (1), wherein the bioprocess system (1) comprises system components (6) comprising at least one monitored system component (22), wherein the system components (6) can be assembled into an assembled state in which the bioprocess system (1) is operational for the bioprocess operation and can be disassembled into a disassembled state in which the bioprocess system (1) is not operational for the bioprocess operation, wherein the bioprocess system (1) comprises a control arrangement (24) and the display arrangement (21) comprises at least one display component (25), wherein in an assembled state of the bioprocess system (1) during a bioprocess operation the control arrangement (24) displays process information via the display arrangement (21) and/or wherein during assembly of the bioprocess system (1) the control arrangement (24) displays assembly information via the display arrangement (21), wherein the process information and/or the assembly information concern at least the monitored system component (22) and wherein the display arrangement (21) comprises at least one display component (25). It is proposed that the display component (25) comprises a light emitting element (27) arranged separate from the monitored system component (22) and arranged next to or on the monitored system component (22) and that the control arrangement (24) is configured to display via the light emitting element (27) the process information and/or the assembly information relating to the monitored system component (22).

Classes IPC  ?

  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
  • G05B 19/409 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par l'utilisation de l'entrée manuelle des données [MDI] ou par l'utilisation d'un panneau de commande, p. ex. commande de fonctions avec le panneauCommande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par les détails du panneau de commande ou par la fixation de paramètres
  • G06F 9/448 - Paradigmes d’exécution, p. ex. implémentation de paradigmes de programmation
  • G05B 19/40 - Systèmes à boucle ouverte, p. ex. utilisant un moteur pas à pas
  • G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques

71.

SOLOHILL

      
Numéro de série 98675875
Statut En instance
Date de dépôt 2024-07-31
Propriétaire Sartorius Stedim North America Inc. ()
Classes de Nice  ? 01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture

Produits et services

Microcarriers for use in manufacturing, laboratory use, and research use; protein-coated microcarrier beads for use in manufacturing, laboratory use, and research use; non-protein coated microcarrier beads for use in manufacturing, laboratory use, and research use; microcarriers for use in preparing cell cultures and in cell culture applications; kits consisting of microcarriers for use in manufacturing, laboratory use, and research use; microcarriers contained in sterilized bags for use in manufacturing, laboratory use, and research use

72.

METHOD FOR INACTIVATING VIRUSES IN A FLUID

      
Numéro d'application EP2024050186
Numéro de publication 2024/149673
Statut Délivré - en vigueur
Date de dépôt 2024-01-05
Date de publication 2024-07-18
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Zilaev, Alexander
  • Leuthold, Martin
  • Grünberg, Mario
  • Wortmeyer, Johannes
  • Lasse, Michael
  • Halt, Alexander
  • Gitt, Silas
  • Deuse, Mario
  • Helling, Alexander
  • Fuest, Marie

Abrégé

The invention relates to a method for inactivating viruses in a fluid, in which method: a starting fluid (AF) containing active viruses is mixed with a virus-inactivating reagent (R1) in a first mixing assembly (2) to form a reactive fluid (F); the active viruses are inactivated via incubation of the reactive fluid (F); and the inactivation of the viruses in the reactive fluid (F) is stopped by mixing the reactive fluid (F) with a further reagent (R2) or by removing the virus-inactivating reagent (R1) from the reactive fluid (F), as a result of which a resulting fluid (RF) is produced. According to the invention, the active viruses are inactivated via incubation of the reactive fluid (F) in a container assembly (3) which comprises a plurality of separate containers (4) and differs from the first mixing assembly (2), wherein the reactive fluid (F) is conducted from the first mixing assembly (2) to the container assembly (3) prior to incubation.

Classes IPC  ?

  • A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet

73.

METHOD FOR GENERATING AND PURIFYING VIRAL VECTORS

      
Numéro d'application EP2024050500
Numéro de publication 2024/149811
Statut Délivré - en vigueur
Date de dépôt 2024-01-10
Date de publication 2024-07-18
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Saballus, Martin
  • Kampmann, Markus

Abrégé

The invention relates to a method for generating and purifying viral vectors (V), wherein the viral vectors (V) are generated by cells in a fluid (F) and wherein the fluid (F) comprising the viral vectors (V) is guided through a tangential flow filtration arrangement (2) for purification, whereby the viral vectors (V) are purified in the fluid (F). It is proposed that the cells and cell debris from the cells, which are contained in the fluid (F) comprising the viral vectors (V) after generating the viral vectors (V), are at least partially separated from the viral vectors (V) by a fluidized bed centrifuge (5) before purification by the tangential flow filtration arrangement (2).

Classes IPC  ?

  • C12N 7/02 - Isolement ou purification
  • C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
  • C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci
  • C12N 15/86 - Vecteurs viraux

74.

PURIFICATION OF VIRUSES, VIRUS-LIKE PARTICLES, AND GLOBULAR BIOMOLECULES BY FILTRATION-SUPPORTED POLYALKYLENE GLYCOL PRECIPITATION

      
Numéro d'application EP2023086320
Numéro de publication 2024/133059
Statut Délivré - en vigueur
Date de dépôt 2023-12-18
Date de publication 2024-06-27
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Pflanz, Karl
  • Labisch, Jennifer

Abrégé

The present invention relates to methods for the purification of viruses, virus-like particles, extracellular vesicles, proteins having a diameter of 5 nm or more, protein complexes having a diameter of 5 nm or more, nucleic acids having a diameter of 5 nm or more, protein-nucleic acid complexes having a diameter of 5 nm or more, and/or molecules having a diameter of 5 nm or more, by filtration-supported polyalkylene glycol precipitation, and to filtration modules that can be used in said methods.

Classes IPC  ?

  • C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
  • B01D 63/08 - Modules à membranes planes
  • B01D 71/10 - CelluloseCellulose modifiée
  • C12N 15/86 - Vecteurs viraux

75.

DEVICE FOR CONTINUOUS VIRUS INACTIVATION

      
Numéro d'application 18283403
Statut En instance
Date de dépôt 2022-03-21
Date de la première publication 2024-06-06
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Schaefer, Jan
  • Weisshaar, Stefan
  • Helling, Alexander
  • Deuse, Mario
  • Diel, Bernhard
  • Tappe, Alexander

Abrégé

Embodiments include a device for continuous virus inactivation during a protein production process comprising a first and a second fluid inlet, a first mixer, and a fluid outlet. A first liquid stream containing a target protein is introducible into the device through the first fluid inlet and is combinable in a predefined volume ratio with a second, virus-inactivating liquid stream introducible into the device through the second fluid inlet to form a third, reactive liquid stream which is conducted through the first mixer for mixing in order to generate predefined, virus-inactivating conditions. The device further comprises a head part and, downstream of the first mixer and upstream of the fluid outlet, a residence time arrangement fluidically connected to the head part for provision of a minimum residence time of the third stream, wherein the head part and the residence time arrangement are rigidly fastened to each other.

Classes IPC  ?

  • C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
  • C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus

76.

ULTRASONIC SENSOR SYSTEMS FOR CHARACTERIZING PARTICLE SUSPENSIONS

      
Numéro d'application 18285587
Statut En instance
Date de dépôt 2022-04-04
Date de la première publication 2024-06-06
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Akbari, Samin
  • Balke, Robert
  • Anderson, Phillip
  • Pollard, David James
  • Ganjian, Amin

Abrégé

Systems and methods for characterizing a plurality of particles suspended in a solution are described. In some embodiments, an ultrasonic interrogation signal may be emitted into a solution including a plurality of particles suspended in the solution. A resulting ultrasonic spectrum may be sensed and provided to a trained statistical model of the solution. The trained statistical model may then determine one or more properties of the plurality of particles.

Classes IPC  ?

  • G01N 29/036 - Analyse de fluides en mesurant la fréquence ou la résonance des ondes acoustiques
  • G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
  • G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
  • G01N 15/06 - Recherche de la concentration des suspensions de particules
  • G01N 29/34 - Génération des ondes ultrasonores, sonores ou infrasonores
  • G01N 29/44 - Traitement du signal de réponse détecté
  • G01N 29/46 - Traitement du signal de réponse détecté par analyse spectrale, p. ex. par analyse de Fourier

77.

METHOD FOR OPERATING A BIOPROCESS INSTALLATION

      
Numéro d'application 18281159
Statut En instance
Date de dépôt 2022-03-10
Date de la première publication 2024-05-30
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Saballus, Martin
  • Reger, Lucas Nik
  • Kampmann, Markus
  • Matuszczyk, Jens-Christoph

Abrégé

A method for operating a bioprocess installation with an electronic process control and at least one bioprocess unit, wherein the bioprocess unit comprises a cell broth source with a first receptacle for cell broth including cultivation media and cells, establishing a culture environment for cell cultivation and/or bio production, wherein the bioprocess unit comprises a clarification setup with a centrifuge for the clarification of the cell broth by centrifugation, with a liquid pumping arrangement assigned to the centrifuge and with a liquid network with a number of liquid lines communicating with the liquid pumping arrangement, wherein out of a first culture environment established by the first receptacle, the cell broth is transfered to the centrifuge via the liquid network, which centrifuge is operated in a forward operation for cell separation and/or cell washing and in a backward operation for cell discharging.

Classes IPC  ?

  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/26 - Inoculateur ou échantillonneur
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies

78.

METHOD AND ARRANGEMENT FOR OPERATING A CONTINUOUS DOWNSTREAM PROCESS

      
Numéro d'application EP2023074974
Numéro de publication 2024/083408
Statut Délivré - en vigueur
Date de dépôt 2023-09-12
Date de publication 2024-04-25
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Diel, Bernhard
  • Rodenberg, Michael

Abrégé

The invention relates to a method for operating a continuous downstream process, in particular a continuous virus activation or inline dilution process, using a bio-process arrangement (1), wherein the bio-process arrangement (1) has a compensating container (2) with a first fluid inlet (3), configured for introduction of a concentrate stream, in particular a product or buffer concentrate stream, into the compensating container (2), with at least one second fluid inlet (4), configured for introduction of a diluent stream, in particular a product or buffer diluent stream, into the compensating container (2), with a fluid outlet (5), configured to discharge a liquid stream from the compensating container (2), wherein the bio-process arrangement (1) has a conveying arrangement (6) for fluid conveyance, which is allocated to the first fluid inlet (3) and to the second fluid inlet (4) for conveying in each case at least one liquid stream into the compensating container (2), and is allocated to the fluid outlet (5) for conveying a liquid stream out of the compensating container (2), and wherein the bio-process arrangement (1) has an electronic process control (7). It is proposed that the electronic process control (7) adapts, by controlling the conveying arrangement (6) in an open-loop and/or closed-loop manner, a fill level in the compensating container (2) such that a predefined minimum fill level in the compensating container (2) is always reached.

Classes IPC  ?

  • B01F 23/40 - Mélange de liquides avec des liquidesÉmulsion
  • B01F 35/83 - Formation d'un rapport prédéterminé des substances à mélanger en commandant le rapport entre plusieurs débits, p. ex. en utilisant des dispositifs de détection ou de commande du débit
  • B01F 35/21 - Mesure
  • B01F 35/22 - Commande ou régulation
  • B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression

79.

Aquasart

      
Numéro d'application 1785748
Statut Enregistrée
Date de dépôt 2023-10-16
Date d'enregistrement 2023-10-16
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 07 - Machines et machines-outils
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement

Produits et services

Cartridges for filtering machines; filters for machines. Laboratory filters. Filters for industrial and household use (terms too vague in the opinion of the International Bureau - Rule 13 (2) (b) of the Common Regulations). filters for industrial installations (terms too vague in the opinion of the International Bureau - Rule 13 (2) (b) of the Common Regulations). filter cartridges for water purification; filters for water filtering apparatus; water purification filters; water treatment filters; water filters for industrial purposes; industrial installations for filtering liquids; water filtering apparatus; water filtering installations; water filtering units; filters (not being parts of machines) as components of filtration systems or as independent filters for the sterilization and purification of liquids and gases for the electronic, pharmaceutical, food, luxury consumer goods and cosmetics industries in general.

80.

Sartofluor

      
Numéro d'application 1785750
Statut Enregistrée
Date de dépôt 2023-10-16
Date d'enregistrement 2023-10-16
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 07 - Machines et machines-outils
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement

Produits et services

Filter housings being parts of machines; filters being parts of machines; filters for gases [machines]; filters for machines; membrane filters for use as parts of machines. Filtering units for laboratory use; laboratory filters. Air filters; air filters for industrial use; air filters for industrial installations; filters for cleaning and sterilizing air; filters for gases [household or industrial installations]; filters for cleaning and sterilizing gases [parts of industrial installations]; filter elements for the air vents of water supply tanks; filters for industrial and household use (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulations); filters for industrial installations (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulations); filters for refrigeration systems; filters for use with bioreactors and fermenters; filters for venting storage tanks; industrial air filter machines; air filter installations; filters, in particular filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury goods, cosmetics and general chemical industries.

81.

METHOD FOR PERFORMING AN INTEGRITY TEST ON A TESTING CONSUMABLE OF A BIOPROCESS INSTALLATION

      
Numéro d'application EP2023077234
Numéro de publication 2024/074451
Statut Délivré - en vigueur
Date de dépôt 2023-10-02
Date de publication 2024-04-11
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s) Chatterjee, Kirit

Abrégé

The invention relates to a method for performing an integrity test on a testing consumable (1) of a bioprocess installation using a test arrangement (2), wherein during a test routine (26), which is being performed by a test control unit (3) of the test arrangement (2), a predetermined test procedure is being applied to the testing consumable (1) via the test arrangement (2) and an integrity state is being derived from process data that have been collected during the test routine (26). It is proposed that during the test routine (26), early process data (27), that are being generated by a testing sensor arrangement (4) of the test arrangement (2) in an early stage of the test procedure, are being used to determine the integrity state of the testing consumable (1) by correlating in a correlating step (28) the early process data (27) to a system model (29) of a reference module (30), which reference module (30) emulates a, in particular integral, testing consumable (1) only in view of predetermined process data.

Classes IPC  ?

  • C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
  • B01D 65/10 - Test de membranes ou d'appareils à membranesDétection ou réparation de fuites
  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
  • G01M 3/22 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour tuyaux, câbles ou tubesExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour raccords ou étanchéité de tuyauxExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour soupapes
  • G01N 15/08 - Recherche de la perméabilité, du volume des pores ou de l'aire superficielle des matériaux poreux

82.

Sartopore Evo

      
Numéro d'application 019012211
Statut Enregistrée
Date de dépôt 2024-04-11
Date d'enregistrement 2024-09-21
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement

Produits et services

Laboratory filters; Filtration membranes for laboratory use; Laboratory filtration apparatus and filtering materials for the filtration of liquids and gases; Filters, for use in relation to the following goods: Laboratory apparatus in the biopharmaceutical industry; Filtration units, For laboratory use. Filters, For industrial purposes; Filtration units; Filtration units, namely Filter cartridges, Filter capsules, Filter modules, Filter capsules and Disposable filters, For industrial purposes; Filters, namely Small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; Filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries.

83.

HOLDING DEVICE FOR A CONTAINER, HAVING A MAGNETIC DRIVE FOR A SEPARATE AGITATOR SHAFT

      
Numéro d'application EP2023077390
Numéro de publication 2024/074527
Statut Délivré - en vigueur
Date de dépôt 2023-10-04
Date de publication 2024-04-11
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Regen, Thomas
  • Burghardt, Sandra
  • Topp-Manske, Simon
  • Husemann, Ute

Abrégé

The invention relates to a holding device (26) for a container, in particular a bioreactor, comprising a magnetic drive (30) for a separate agitator shaft (28) and a lever device (10) for releasing the agitator shaft (28) from the magnetic drive (30). The magnetic drive (30) has a first coupling side (32) and the agitator shaft (28) has a second coupling side (34) of a magnetic coupling, said second coupling side being connectable to the first coupling side (32). The lever device (10) has at least one pressure portion (22; 64) and is pivotable between a closing position and a release position. As the lever device (10) is pivoted into the release position, the pressure portion (22; 64) is moved downwards in order to act directly or indirectly on the agitator shaft (28).

Classes IPC  ?

  • B01F 33/453 - Mélangeurs magnétiquesMélangeurs avec agitateurs à entraînement magnétique en utilisant des éléments d'agitation supportés ou suspendus
  • B01F 27/213 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins caractérisés par leurs arbres de rotation caractérisés par la liaison avec l'entraînement

84.

Sartovent

      
Numéro d'application 019006063
Statut Enregistrée
Date de dépôt 2024-03-28
Date d'enregistrement 2024-08-10
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement

Produits et services

Laboratory filters; Filtration membranes for laboratory use; Filters, for use in relation to the following goods: Laboratory apparatus in the biopharmaceutical industry; Filtration units, For laboratory use; Breather filters, For laboratory use. Filters, For industrial purposes; Filtration units, namely Filter cartridges, Filter capsules and Disposable filters, For industrial purposes; Filters, namely Small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; Filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries; Air filters; Air filters for industrial use; Air filters for industrial installations; Gas filters (industrial installations); Industrial air filter machines; Air filtering installations; Filters for purifying gaseous media and sterile ventilation of closed containers, conduits and tube systems; Filters for cleaning and sterilizing air; Parts of industrial installations, namely Filters for cleaning and sterilizing gases; Filters, for use in relation to the following goods: Transport container; Filters, for use in relation to the following goods: Containers, of plastic; Container attachment filters; Ventilation filters, For industrial purposes; Filters for the sterile gas exchange of containers; Filter elements for the air vents of water supply tanks; Filters for venting storage tanks; Filters for refrigeration systems; Filters, for use in relation to the following goods: Bio-reactors and Fermenters.

85.

METHOD OF CHANGING CULTURE MEDIUM OF A CULTURE USING SPINFILTERS

      
Numéro d'application 18262433
Statut En instance
Date de dépôt 2022-01-21
Date de la première publication 2024-03-21
Propriétaire
  • SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
  • REPAIRON GMBH (Allemagne)
Inventeur(s)
  • Haupt, Luis
  • Hupfeld, Julia

Abrégé

The present invention relates to a method of expanding stem cells cultured as cell aggregates in a suspension culture changing culture medium and a method of medium exchange for the same cells characterized in the use of a rotating mesh such as a spinfilter device. The present invention further relates to a use of a rotating mesh for medium exchange in a suspension culture of stem cells.

Classes IPC  ?

  • C12N 5/074 - Cellules souches adultes
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/06 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'introduction de gaz avec agitateur, p. ex. avec agitateur à turbine

86.

METHOD FOR OPERATING A BIOPROCESS INSTALLATION FOR PRODUCTION OF A BIOPRODUCT

      
Numéro d'application EP2023074979
Numéro de publication 2024/056640
Statut Délivré - en vigueur
Date de dépôt 2023-09-12
Date de publication 2024-03-21
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Reger, Lucas Nik
  • Saballus, Martin
  • Kampmann, Markus
  • Niemann, Julia

Abrégé

The invention relates to a method for operating a bioprocess installation (1) for production of a bioproduct, wherein the bioprocess installation (1) comprises a source receptacle (2) for cell cultivation, a harvest receptacle (3) for bioproduction and a clarification setup (4) with a centrifuge (12), wherein the source receptacle (2) is operated in a cyclical production mode comprising the steps of: a) starting the cyclical production mode in the source receptacle (2) b) cultivating the cells in the source receptacle (2), thereby obtaining a cell broth (7) comprising cultivated cells, c) discharging a discharge fraction (16) of the cell broth (7) from the source receptacle (2), d) combining a restart fraction (17) of the cell broth (7) with fresh cultivation medium (8) and repeating step b), e) repeating steps c) and d) at least once and/or f) discharging the cell broth (7) obtained from step d) from the source receptacle (2) stopping the cyclical production mode, obtaining a discharge fraction (16), wherein the method further comprises the steps of: i) centrifuging the discharge fraction (16) via the centrifuge (12), thereby separating the discharge fraction (16) into at least a centrifuged discharge fraction (19) and supernatant (14) and preferably bioproduct, ii) operating the harvest receptacle (3) in a production mode, wherein steps i) and ii) are executed at least twice.

Classes IPC  ?

  • C12M 1/107 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens pour recueillir les gaz de fermentation, p. ex. le méthane
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
  • C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/26 - Inoculateur ou échantillonneur

87.

Sartobind Convec

      
Numéro d'application 018999682
Statut Enregistrée
Date de dépôt 2024-03-15
Date d'enregistrement 2024-10-09
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Classes de Nice  ?
  • 07 - Machines et machines-outils
  • 09 - Appareils et instruments scientifiques et électriques
  • 11 - Appareils de contrôle de l'environnement
  • 17 - Produits en caoutchouc ou en matières plastiques; matières à calfeutrer et à isoler

Produits et services

Filter modules, namely filter capsules, filter candles, filter cassettes, coil modules, filter coils, filter coils in connection with filter centrifuges, band filters, small filters, small filters in connection with centrifuge tubes and as centrifugal concentrators, disposable filters; membrane filters and filter matting being parts of machines, for use in biotechnology, environmental protection, for the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and for use in genetic engineering, medicine and in laboratories, and for treatment and analysis of water and effluent; filters being parts of machines; membrane filters for use as part of machines. Laboratory filters; Filtering units for laboratory use; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors sold as a set for laboratory use; membranes for filtration [scientific]; filters for use with laboratory chromatography apparatus; membrane filters and filter matting with adsorption properties, membrane adsorbers, namely adsorption membranes, ion exchange membranes, ligand membranes and activated membranes in the form of hollow fibre membranes, tube membranes and flat membranes as strips or cut to size for use in apparatus, filters and filter modules for the aforesaid fields of application; membrane filters and filter matting as parts of microtitre plates; membrane filters and filter matting as parts of diagnostic tests such as diagnostic assays and immunoassays; membrane filters and filter matting as parts of filter systems or as independent filters for chromatographic analyses and chemical separation, reconcentration, for sterilisation and ultrapurification of fluids; filters and filter modules for filtering and reconcentration of biological solutions, namely of viral and bacterial suspensions; filters and filter modules for treating blood and other bodily fluids. Filters and filtering units, for industrial use; filters for filtering fluids, filter modules, filter candles and filter capsules; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors, sold as a set, for industrial installations; Filters for water filtering apparatus; Cartridge filtration units [water treatment equipment]; filters for use with industrial chromatography apparatus; apparatus for water treatment and for preparing solutions in the pharmaceutical, medical and laboratory fields; equipment for de-ionising water; equipment for de-pyrogenisation of solutions and for separating harmful substances from fluids; filters and filter modules for desalination of protein solutions and other biological media; filters and filter modules for analysis and separation of ions, macromolecules and biomolecules, namely carbohydrates, peptides, proteins and nucleic acids and for separating heavy metals and harmful substances from fluids; filters for industrial use, namely, membrane filters and filter matting having applications in biotechnology, environmental protection, the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and in genetic engineering, medicine and laboratories, and the treatment and analysis of water and effluents. Membranes and semi-processed synthetic filtering materials; Polymeric membranes; Polymeric porous membranes in hollow fibre form; Polymeric porous membranes in sheet form; Transfer membranes of cellulose derivatives; Transfer membranes of cellulose; Transfer membranes of polyamides; Transfer membranes of polyvinylidene fluoride; Cross-linked polymeric membranes in sheet form; Cross-linked polymeric membranes in hollow fibre form.

88.

METHOD FOR A DYNAMIC IN-LINE MIXING PROCESS

      
Numéro d'application EP2023074162
Numéro de publication 2024/052275
Statut Délivré - en vigueur
Date de dépôt 2023-09-04
Date de publication 2024-03-14
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Diel, Bernhard
  • Schäfer, Jan

Abrégé

The invention relates to a method for a dynamic in-line mixing process of a pressurized medium (1), which contains a liquid and at least one additional liquid or solid constituent, in a bioprocess assembly (3). The liquid is combined with the at least one additional liquid or solid constituent in a specified volume ratio at an opening point (4) in order to form a resulting liquid flow (5), wherein the bioprocess assembly (3) has a pump assembly (8) with a first pump (9), the first pump (9) is arranged in the line (7) of the line assembly (6), the first pump (9) is designed as a rotary pump (10), in particular a centrifugal pump, which is designed for a dynamic in-line mixing process of the medium (1), the first pump (9) has a liquid inlet (9a) which forms the suction side of the pump when operated as intended and a liquid outlet (9b) which forms the pressure side of the pump when operated as intended, and the medium (1) is conducted through the rotary pump (10) for a dynamic in-line mixing process. According to the invention, the medium flows through the rotary pump (10) in the opposite flow direction, in comparison to the intended operation, for the dynamic in-line mixing process.

Classes IPC  ?

  • B01F 25/64 - Mélangeurs à pompe, c.-à-d. mélange à l'intérieur d'une pompe de type à pompe centrifuge, c.-à-d. turbo-mélangeurs

89.

DEVICE ASSEMBLY AND METHOD FOR CONTROLLING AN INTEGRATED CONTINUOUS PHARMACEUTICAL OR BIOPHARMACEUTICAL MANUFACTURING PROCESS

      
Numéro d'application 18271905
Statut En instance
Date de dépôt 2021-11-25
Date de la première publication 2024-02-29
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Lemke, Johannes
  • Matuszczyk, Jens-Christoph
  • Höhse, Marek
  • Söldner, Robert
  • Graf, Alexander

Abrégé

A device assembly for controlling an integrated continuous pharmaceutical or biopharmaceutical manufacturing process including a first process equipment for performing a first process step; a second process equipment for performing a second process step subsequent to the first process step; a single measuring unit for measurement of a set of signals of a liquid process medium at a single location, the measured signals depending on first and second parameters; and an evaluation and control unit for evaluating the measured signals to determine values of the first and second parameters. The evaluation and control unit determines first and second corrective feedback based on the values of the first and second parameters, respectively. The evaluation and control unit controls the first process step by providing the first corrective feedback to the first process equipment and controls the second process step by providing the second corrective feedback to the second process equipment.

Classes IPC  ?

  • G05B 11/01 - Commandes automatiques électriques
  • G01J 3/02 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur Parties constitutives

90.

Valve switching system for selectively interconnecting components of a bioprocess installation

      
Numéro d'application 17896645
Numéro de brevet 12306146
Statut Délivré - en vigueur
Date de dépôt 2022-08-26
Date de la première publication 2024-02-29
Date d'octroi 2025-05-20
Propriétaire Sartorius Stedim North America Inc. (USA)
Inventeur(s) Shukla, Dinesh

Abrégé

Various embodiments are directed to a valve switching system for selectively interconnecting components of a bioprocess installation, comprising a valve switching cassette and an actuator block. It is proposed, that the valve switching cassette comprises a perforated backer plate securing a valve membrane structure to a cassette manifold, that the actuator block comprises a drive membrane structure with at least one drive membrane and a perforated backer plate securing the drive membrane structure to an actuator block body, wherein for selectively switching valve units, an actuator of the actuator block may urge the drive membrane structure through aligned perforation holes of both backer plates into engagement with the valve membrane structure.

Classes IPC  ?

  • G01N 30/46 - Modèles d'écoulement utilisant plus d'une colonne
  • B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement

91.

VALVE SWITCHING SYSTEM FOR SELECTIVELY INTERCONNECTING COMPONENTS OF A BIOPROCESS INSTALLATION

      
Numéro d'application US2023030451
Numéro de publication 2024/044090
Statut Délivré - en vigueur
Date de dépôt 2023-08-17
Date de publication 2024-02-29
Propriétaire SARTORIUS STEDIM NORTH AMERICA INC. (USA)
Inventeur(s) Shukla, Dinesh

Abrégé

x,yx,yx,y), an actuator of the actuator block (16) may urge the drive membrane structure (23) through aligned perforation holes (25, 26) of both backer plates (22, 24) into engagement with the valve membrane structure (20).

Classes IPC  ?

  • G01N 30/38 - Modèles d'écoulement
  • B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
  • F16K 7/00 - Dispositifs d'obturation à diaphragme, p. ex. dont un élément est déformé, sans être déplacé entièrement, pour fermer l'ouverture
  • G01N 30/46 - Modèles d'écoulement utilisant plus d'une colonne
  • G01N 30/32 - Contrôle des paramètres physiques du fluide vecteur de la pression ou de la vitesse

92.

METHOD AND APPARATUS FOR VALIDATING A FILTER UNIT

      
Numéro d'application EP2023072662
Numéro de publication 2024/038135
Statut Délivré - en vigueur
Date de dépôt 2023-08-17
Date de publication 2024-02-22
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Austerjost, Jonas
  • Söldner, Robert
  • Rafigh, Mehran
  • Scholz, Jochen

Abrégé

Disclosed is inter alia a method for validating a filter unit, wherein the method comprises: - guiding a fluid flow of a fluid, after the fluid flow passed through the filter unit, to a measurement area that is connected to the filter unit, wherein within the measurement area the fluid is exposed to at least one alternating electric field between at least two electrodes; - obtaining at least one electric signal between the at least two electrodes, wherein the at least one electric signal is at least affected by whether one or more cells of a plurality of cells in the fluid pass through the measurement area; and - determining, at least partially based on the obtained at least one electric signal, at least one validity information indicating a validity of the filter unit.

Classes IPC  ?

  • G01N 15/08 - Recherche de la perméabilité, du volume des pores ou de l'aire superficielle des matériaux poreux

93.

BIOREACTOR SYSTEM WITH GAS SUPPLY FACILITY

      
Numéro d'application EP2023070228
Numéro de publication 2024/037823
Statut Délivré - en vigueur
Date de dépôt 2023-07-20
Date de publication 2024-02-22
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s)
  • Leopold, Marco
  • Husemann, Bernward
  • Steinicke, Robert
  • Becker, Sören
  • Adams, Thorsten

Abrégé

A bioreactor system (10) for carrying out a biological process comprises a container (12) for receiving a liquid biological medium and a gas supply facility for feeding various gases from gas sources (38, 40, 42, 44) into the container (12) in a controlled manner. The gas supply facility has a plurality of gas outlet lines (28, 30, 32) which open into one or more gas supply devices (20) and/or into an overlay gas outlet in the interior of the container (12). Each gas outlet line (28, 30, 32) is connected to multiple gas sources (38, 40, 42, 44) by a respective gas supply line (46, 52, 56, 58) or by a respective branch (48, 50, 54, 60) of a gas supply line (46, 52, 56, 58). A mass flow regulator (62), which is connected to a control unit, is arranged in each gas supply line (46, 52, 56, 58) and in each branch (48, 50, 54, 60). Such a bioreactor system for carrying out a biological process preferably comprises a controller, which comprises a master regulator for a controlled variable, at least one sensor associated with the master regulator and one or more follower regulators with actuators (14, 62), the manipulated variables of which influence the controlled variable in a targeted manner. The controller is designed such that a setpoint value for the controlled variable can be prespecified to the master regulator, the at least one sensor is used for repeated determination of an actual value of the controlled variable, and the master regulator provides to the follower regulators an output signal dependent upon the deviation of the actual value of the controlled variable from the setpoint value of the controlled variable. Control profiles, which are dependent upon the output signal of the master regulator, are assigned to the follower regulators. According to a first alternative, the control profiles contain setpoint values for the actuators (14, 62) of the follower regulators, and the controller is designed such that the setpoint values for the actuators (14, 62) can be input in the physical unit of their manipulated values. According to a second alternative, the control profiles contain setpoint values for a parameter that relates directly to the biological process and can be influenced in a targeted manner by the actuators (14, 62), and the controller is designed such that it automatically assigns setpoint values for the actuators of the follower regulators to the parameter setpoint values.

Classes IPC  ?

  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
  • C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies

94.

QUICK DISSOLVING CAVITY FORMING STRUCTURE FOR INJECTION MOLDED STRUCTURES

      
Numéro d'application 18266890
Statut En instance
Date de dépôt 2021-12-14
Date de la première publication 2024-02-15
Propriétaire Sartorius Stedim North America Inc. (USA)
Inventeur(s)
  • Zumbrum, Michael
  • Kimmick, William

Abrégé

A method of molding an article includes positioning a dissolvable insert within a mold, filling the mold with material to form an article within the mold and about the dissolvable insert, and at least partially dissolving the dissolvable insert from within the article. The dissolvable insert forms internal features of the article and includes a porous core.

Classes IPC  ?

  • B29C 45/44 - Démoulage ou éjection des objets formés d'objets à contre-dépouille
  • B29C 33/52 - Moules ou noyauxLeurs détails ou accessoires comportant des moyens ou conçus spécialement pour faciliter le démoulage d'objets, p. ex. des objets à contre-dépouille solubles ou fusibles

95.

CONTINUOUS FLOW CENTRIFUGE

      
Numéro d'application EP2023071664
Numéro de publication 2024/033257
Statut Délivré - en vigueur
Date de dépôt 2023-08-04
Date de publication 2024-02-15
Propriétaire SARTORIUS STEDIM NORTH AMERICA INC., (USA)
Inventeur(s) Tödteberg, Eckhard

Abrégé

The invention relates to a continuous flow centrifuge (1) comprising a rotor (6). The continuous flow centrifuge (1) comprises a connecting strand (12) having connection lines (16, 17), via which an exchange of media in containers (8a, 8b) arranged in the centrifugation chambers of the rotor (6) is possible. According to the invention, a temperature-control supply line (14) and a temperature-control discharge line (16) for a connecting strand temperature-control fluid extends through the connecting strand (12) in order to counteract a heating of the connecting strand (12) due to flexing and friction occurring therein. The connecting strand temperature-control fluid flows through the temperature-control supply line (14) and the temperature-control discharge line (15) in opposing flow directions. An electronic control unit (28) has a control logic which controls the connecting strand temperature-control power of a connecting strand temperature-control circuit (36) in an open-loop or closed-loop manner.

Classes IPC  ?

  • B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p. ex. butyromètres
  • B04B 15/02 - Autres accessoires pour centrifugeurs pour le refroidissement, le chauffage, ou l'isolation thermique

96.

FLOW-THROUGH CENTRIFUGE AND METHOD FOR PRODUCING AN OPERATIONALLY READY STATE OF A FLOW-THROUGH CENTRIFUGE

      
Numéro d'application EP2023071953
Numéro de publication 2024/033371
Statut Délivré - en vigueur
Date de dépôt 2023-08-08
Date de publication 2024-02-15
Propriétaire SARTORIUS STEDIM BIOTECH GMBH (Allemagne)
Inventeur(s) Bittner, Fabian

Abrégé

The invention relates to a flow-through centrifuge (1), which can be used for example for biotechnological applications, in particular in the form of a blood centrifuge (2). A drive and/or transmission assembly (19) of the through-flow centrifuge (1) has a planetary transmission (62). At least one planetary belt pulley (34; 36) is rotatably mounted on a rotating planet carrier (18) in the planetary transmission (62), and the torque of the planetary belt pulley (34; 36) is transmitted via a belt (33; 37), wherein the planet carrier (18) and the belt pulley (34; 36) are driven at different rotational speeds. According to the invention, the planet carrier (18) is held via a belt-tensioning unit (17) which rotates together with the planet carrier (18), and the distance (42) between the planet carrier (18) and a rotor axis (4) can be modified via the belt-tensioning unit (17) in order to set the tension of the belt (33; 37).

Classes IPC  ?

  • B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p. ex. butyromètres
  • B04B 9/08 - Agencements des mécanismes de transmission

97.

CONTINUOUS-FLOW CENTRIFUGE AND COMPENSATION-ROTOR GUIDE DEVICE

      
Numéro d'application EP2023071662
Numéro de publication 2024/033255
Statut Délivré - en vigueur
Date de dépôt 2023-08-04
Date de publication 2024-02-15
Propriétaire SARTORIUS STEDIM NORTH AMERICA INC. (USA)
Inventeur(s) Sander, Michael

Abrégé

The invention relates to a continuous-flow centrifuge comprising a rotor which has at least one centrifugation chamber and rotates about a rotor axis (7) at a rotor speed. The continuous-flow centrifuge comprises a connecting strand (12) through which connecting lines (16, 17) extend. A medium can be supplied to the centrifugation chamber, and the medium can be discharged from the centrifugation chamber, via the connecting lines (16, 17) during operation of the continuous-flow centrifuge with the rotor rotating. One end region (18) of the connecting strand (12) is fixed to the housing, whereas the other end region (19) of the connecting strand (12) rotates with the rotor. To prevent the connecting strand (12) from twisting, the connecting strand (12) is guided in a compensation-rotor guide device (20) (in particular a guide tube (21)) which rotates about the rotor axis (7) at half the rotor speed. According to the invention, the compensation-rotor guide device (20) has a guide contour (27), the radius of curvature (32) of which is greater in a first guide-contour section (28) than the radius of curvature (33) in a second guide-contour section (29). As a result, the service life of the connecting strand (12) can be increased.

Classes IPC  ?

  • B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p. ex. butyromètres

98.

INTEGRITY TEST FOR A DOUBLE FILTER CAPSULE

      
Numéro d'application 18259032
Statut En instance
Date de dépôt 2021-12-22
Date de la première publication 2024-02-08
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Friese, Thomas
  • Strauss, Mario
  • Müller, Katrin
  • Loewe, Thomes

Abrégé

A method for providing an integrity test of a double filter capsule can include providing the double filter capsule in such a way that in a filtration process the medium to be filtered flows in its flow direction from an upstream chamber in the housing through a first filter into an intermediate chamber between the first filter and a second filter and then through the second filter to an outlet. The housing can have an upstream-chamber access point for feeding a test fluid into the upstream chamber and an intermediate-chamber access point for feeding the test fluid into the intermediate chamber. Additional steps can include providing a connecting line between the upstream-chamber access point and the intermediate-chamber access point and determining the state of integrity of the double filter capsule on the basis of at least two test phases.

Classes IPC  ?

  • B01D 65/10 - Test de membranes ou d'appareils à membranesDétection ou réparation de fuites
  • B01D 29/11 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants avec des éléments filtrants en forme de sac, de cage, de tuyau, de tube, de manchon ou analogue
  • B01D 29/56 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants à plusieurs éléments filtrants caractérisés par leur agencement relatif montés en série

99.

INSTALLATION FOR BIOTECHNOLOGICAL APPLICATIONS, WITH CARRIER FOR THE MOUNTING OF COMPONENTS

      
Numéro d'application 18491110
Statut En instance
Date de dépôt 2023-10-20
Date de la première publication 2024-02-08
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Heese, Robin
  • Klemm, Andreas
  • Grebe, André
  • Rodenberg, Michael

Abrégé

A method for mounting at least one component on an installation includes attaching a carrier directly or indirectly to the installation, where the installation has at least one frame with at least two arms, at least one base plate, and at least one deformable element. The method further includes displacing the component toward the deformable element such that the deformable element is displaced from a receiving state (AUZ), in which the deformable element is ready to receive the component of the installation, toward a locked state (ARZ), as a result of which the deformable element surrounds and mounts the component of the installation at least in part.

Classes IPC  ?

  • C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
  • C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

100.

CHROMATOGRAPHIC MATERIAL AND METHOD OF PRODUCING SAME

      
Numéro d'application 18258672
Statut En instance
Date de dépôt 2021-12-21
Date de la première publication 2024-02-01
Propriétaire Sartorius Stedim Biotech GmbH (Allemagne)
Inventeur(s)
  • Ley, Adrian
  • Petersen, Rebecca
  • Taft, Florian
  • Adametz, Patrick
  • Thiefes, Axel
  • Toeppner, Kathrin
  • Weber, Stella
  • Gehrmann, Nils
  • Hagemann, Franziska
  • Thom, Volkmar

Abrégé

The present invention relates to a chromatographic material comprising a polymer network material-based self-supporting bi-continuous separation matrix for adsorptive material separation in liquid media, and a method of producing the chromatographic material comprising a polymer network material-based self-supporting bi-continuous separation matrix.

Classes IPC  ?

  • B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
  • B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
  • B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
  • B01J 20/285 - Absorbants ou adsorbants poreux à base de polymères
  1     2     3     ...     11        Prochaine page