The present disclosure relates to an (in situ gelling) enema containing Rifamycin SV and its use in the treatment of pouchitis, proctitis and/or distal ulcerative colitis (including proctosigmoiditis). More particularly, the present disclosure describes an in situ gelling retentive enema containing Rifamycin SV for treating, ameliorating, reducing the severity of or slowing the progression of pouchitis, proctitis and/or distal ulcerative colitis (including proctosigmoiditis).
Oral pharmaceutical compositions containing rifamycin SV, or a pharmaceutically salt thereof, characterized in that they are formulated in a higher strength (about 600 mg/tablet) and in such a manner to obtain a modified profile of the rifamycin SV, or a pharmaceutically acceptable salt thereof, in the proximal portion of the intestine, i.e. in the small intestine (duodenum, jejunum and ileum). In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of small intestine bacterial overgrowth (SIBO) and/or irritable bowel syndrome (IBS) and/or in the treatment of cholera. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of hepatic encephalopathy, hepatic cirrhosis, pouchitis and/or spontaneous bacterial perotinitis. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of non-alcoholic fatty liver disease, non-alcoholic fatty liver or non-alcoholic steatohepatitis.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations; Medicines for human purposes; Medical reagent; Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy; Diagnostic agents, preparations and substances for medical purposes, namely, the visualization of colonic polyps, adenomas, carcinomas, early stage cancers and other lesions in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), those with previous history of polyps, adenomas, carcinomas, early stage cancers and other lesions, patients with colorectal cancer and patients with relevant family history; Diagnostic reagents and coloring agent for medical and surgical use; Coloring agent for use with imaging medical equipment; Coloring agent for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and polyps, adenomas, carcinomas, early stage cancers and other lesions thereon; pharmaceutical preparations for use in endoscopic or colonoscopic diagnostic evaluation; pharmaceutical preparations for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions during gastrointestinal endoscopic procedures; pharmaceutical preparations for use in gastroenterology for colon and digestive system health and regulation; pharmaceutical preparations for use in endoscopy of the gastrointestinal tract; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention and treatment related to the gastrointestinal field; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention and treatment related to the gastrointestinal endoscopy field; pharmaceutical preparations to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; pharmaceutical preparations, namely, coloring agent for use in endoscopic procedures; pharmaceutical compositions, namely, coloring agent for use in endoscopy; pharmaceutical preparations for use as reagents for medical use; pharmaceutical preparations, namely, coloring agent for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for enhancing visualization during endoscopic procedures; pharmaceutical preparations containing dyes for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue coloring agent for pharmaceutical, medical and surgical purposes; pharmaceutical preparations containing coloring agent dye for pharmaceutical, medical and surgical purposes; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations; medicines for human purposes;
medical reagent; diagnostic agents, preparations and
substances for medical and surgical purposes; diagnostic
agents, preparations and substances for medical purposes,
namely, the visual enhancing of polyps, adenomas,
carcinomas, early stage cancers and other lesions in the
colon for patients undergoing colonoscopy; diagnostic
agents, preparations and substances for medical purposes,
namely, the visualization of colonic polyps, adenomas,
carcinomas, early stage cancers and other lesions in
patients undergoing screening colonoscopy including patients
at high risk of colorectal carcinoma (CRC), those with
previous history of polyps, adenomas, carcinomas, early
stage cancers and other lesions, patients with colorectal
cancer and patients with relevant family history; diagnostic
reagents and coloring agent for medical and surgical use;
coloring agent for use with imaging medical equipment;
coloring agent for use with colonoscopic equipment;
pharmaceutical preparations for use in gastroenterology;
pharmaceutical preparations for the differentiation of the
tissues of the intestines and colon and polyps, adenomas,
carcinomas, early stage cancers and other lesions thereon;
pharmaceutical preparations for use in endoscopic or
colonoscopic diagnostic evaluation; pharmaceutical
preparations for enhancing visualization of polyps,
adenomas, carcinomas, early stage cancers and other lesions
during gastrointestinal endoscopic procedures;
pharmaceutical preparations for use in gastroenterology for
colon and digestive system health and regulation;
pharmaceutical preparations for use in endoscopy of the
gastrointestinal tract; pharmaceutical preparations and
preparations aiding detection, diagnosis, prevention and
treatment related to the gastrointestinal field;
pharmaceutical preparations and preparations aiding
detection, diagnosis, prevention and treatment related to
the gastrointestinal endoscopy field; pharmaceutical
preparations to aid the detection, diagnosis, prevention and
treatment of gastroenterological diseases; pharmaceutical
preparations, namely, coloring agent for use in endoscopic
procedures; pharmaceutical compositions, namely, coloring
agent for use in endoscopy; pharmaceutical preparations for
use as reagents for medical use; pharmaceutical
preparations, namely, coloring agent for use in endoscopy,
colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and
proctoscopy; pharmaceutical preparations containing
methylene blue for enhancing visualization during endoscopic
procedures; pharmaceutical preparations containing dyes for
enhancing visualization during endoscopy, colonoscopy,
sigmoidoscopy, anoscopy, rectoscopy and proctoscopy;
pharmaceutical preparations containing methylene blue
coloring agent for pharmaceutical, medical and surgical
purposes; pharmaceutical preparations containing coloring
agent dye for pharmaceutical, medical and surgical purposes;
methylene blue for pharmaceutical, medical, surgical and
medical diagnostic purposes; dye for pharmaceutical,
medical, surgical and medical diagnostic purposes. Medical apparatus and instruments; diagnostic apparatus for
medical purposes; medical devices for use in endoscopic
procedures of the gastrointestinal tract; medical devices to
aid the detection, diagnosis, prevention and treatment of
gastroenterological diseases; medical instruments to aid the
detection, diagnosis, prevention and treatment of
gastroenterological diseases; medical devices for enhancing
visualization during endoscopic procedures; medical devices
for enhancing visualization during endoscopy, colonoscopy,
sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; medical
devices for introducing compositions containing methylene
blue into the human body for pharmaceutical, medical,
surgical and medical diagnostic purposes; medical devices
for introducing compositions containing dye into the human
body for pharmaceutical, medical, surgical and medical
diagnostic purposes; medical devices made with methylene
blue for enhancing visualization of polyps, adenomas,
carcinomas, early stage cancers and other lesions for
pharmaceutical, medical, surgical and medical diagnostic
purposes; medical devices made with dye for enhancing
visualization of polyps, adenomas, carcinomas, early stage
cancers and other lesions for pharmaceutical, medical,
surgical and medical diagnostic purposes; medical devices
for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy,
rectoscopy and proctoscopy; medical devices for use in
endoscopy of the gastrointestinal tract.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy and for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical and surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations; Medicines for human purposes; Medical reagent; Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy; Diagnostic agents, preparations and substances for medical purposes, namely, the visualization of colonic polyps, adenomas, carcinomas, early stage cancers and other lesions in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), those with previous history of polyps, adenomas, carcinomas, early stage cancers and other lesions, patients with colorectal cancer and patients with relevant family history; Diagnostic reagents and coloring agent for medical and surgical use; Coloring agent for use with imaging medical equipment; Coloring agent for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and polyps, adenomas, carcinomas, early stage cancers and other lesions thereon; pharmaceutical preparations for use in endoscopic or colonoscopic diagnostic evaluation; pharmaceutical preparations for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions during gastrointestinal endoscopic procedures; pharmaceutical preparations for use in gastroenterology for colon and digestive system health and regulation; pharmaceutical preparations for use in endoscopy of the gastrointestinal tract; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention and treatment related to the gastrointestinal field; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention and treatment related to the gastrointestinal endoscopy field; pharmaceutical preparations to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; pharmaceutical preparations, namely, coloring agent for use in endoscopic procedures; pharmaceutical compositions, namely, coloring agent for use in endoscopy; pharmaceutical preparations for use as reagents for medical use; pharmaceutical preparations, namely, coloring agent for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for enhancing visualization during endoscopic procedures; pharmaceutical preparations containing dyes for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue coloring agent for pharmaceutical, medical and surgical purposes; pharmaceutical preparations containing coloring agent dye for pharmaceutical, medical and surgical purposes; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes. Medical apparatus and instruments; Diagnostic apparatus for medical purposes; Medical devices for use in endoscopic procedures of the gastrointestinal tract; Medical devices to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; Medical instruments to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; Medical devices for enhancing visualization during endoscopic procedures; Medical devices for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for introducing compositions containing methylene blue into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices for introducing compositions containing dye into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with methylene blue for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with dye for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for use in endoscopy of the gastrointestinal tract.
The invention provides a composition for use as a delivery vehicle comprising at least one thermo-responsive polymer (polymer A) and at least one ion-sensitive polymer (polymer B) in a liquid formulation. Polymer A is preferably a polyoxyethylene-poly-oxypropylene block copolymer or a cellulose derivative. Polymer B is preferably a polysaccharide. The composition can include an active substance for delivery or can be used as a delivery vehicle for a substance added at the time of administration such as mesenchymal stem cells.
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
8.
17A-MONOESTERS AND 17A,21-DIESTERS OF CORTEXOLONE FOR USE IN THE TREATMENT OF TUMORS
The present invention relates to certain cortexolone derivatives of formula (I)
The present invention relates to certain cortexolone derivatives of formula (I)
The present invention relates to certain cortexolone derivatives of formula (I)
and the use of the same as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. The present invention also relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of the pharmaceutical compositions as antitumor medicinal products.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
C07J 5/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone, p. ex. prégnane, et substitués en position 21 par seulement une unique liaison carbone-oxygène
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer hardware used for the detection, identification and diagnosis of lesions and other pathology in gastrointestinal tracts and digestive systems during colonoscopy, endoscopy, or gastroscopy procedures; tablet computers; tablet computers which allow interactive access to artificial intelligence content; artificial intelligence software used for the detection, identification and diagnosis of lesions and other pathology in gastrointestinal tracts and digestive systems during colonoscopy, endoscopy, or gastroscopy procedures; medical hardware and software for receiving, analyzing, managing, processing, reporting and displaying sensor data from gastrointestinal tracts and digestive systems; artificial intelligence software for healthcare; artificial intelligence devices for the detection of lesions during colonoscopy; software to assist in detecting polyps. Medical devices for use in chromoendoscopy and endoscopy procedures of the gastrointestinal tract; medical devices to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; medical instruments to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; medical devices for enhancing visualization during chromoendoscopy, endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy procedures. Software as a Service and Platform as a Service used in the detection, identification and diagnosis of lesions and other pathology in gastrointestinal tracts and digestive systems during colonoscopy, endoscopy, or gastroscopy procedures; Software as a Service and Platform as a Service incorporating artificial intelligence to aid in the the detection, identification and diagnosis of lesions and other pathology in gastrointestinal tracts and digestive systems during colonoscopy, endoscopy, or gastroscopy procedures; Software as a Service and Platform as a Service to assist in detecting polyps; Software as a Service and Platform as a Service for receiving, analyzing, managing, processing, reporting and displaying sensor data from gastrointestinal tracts and digestive systems.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer hardware used for the detection, identification and diagnosis of lesions and other pathology in gastrointestinal tracts and digestive systems during colonoscopy, endoscopy, or gastroscopy procedures; tablet computers; tablet computers using artificial intelligence comprised of voice-activated speakers, computer hardware, and recorded software for controlling networked devices in the internet of things (IoT), operating internet-enabled and connected lighting apparatus and home security alarms; Recorded computer software using artificial intelligence for the detection, identification and diagnosis of lesions and other pathology in gastrointestinal tracts and digestive systems during colonoscopy, endoscopy, or gastroscopy procedures; computer hardware and recorded software for receiving, analyzing, managing, processing, reporting and displaying sensor data from gastrointestinal tracts and digestive systems; Recorded computer software using artificial intelligence for healthcare management; Recorded computer software using artificial intelligence for the detection of lesions during colonoscopy; downloadable software to assist in detecting polyps Medical devices for use in chromoendoscopy and endoscopy procedures of the gastrointestinal tract for viewing internal organs, listening to internal organs; medical devices to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; medical instruments to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; medical
devices for enhancing visualization during chromoendoscopy, endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy procedures Software as a service (SaaS) and Platform as a service (PaaS) featuring software for detection, identification and diagnosis of lesions and other pathology in gastrointestinal tracts and digestive systems during colonoscopy, endoscopy, or gastroscopy procedures; Software as a service (SaaS) and Platform as a service (PaaS) featuring software for using artificial intelligence for the detection, identification and diagnosis of lesions and other pathology in gastrointestinal tracts and digestive systems during colonoscopy, endoscopy, or gastroscopy procedures; Software as a service (SaaS) and Platform as a service (PaaS) featuring software for detecting polyps; Software as a service (SaaS) and Platform as a service (PaaS) featuring software for receiving, analyzing, managing, processing, reporting and displaying sensor data from gastrointestinal tracts and digestive systems
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations; Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy and for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical and surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes; pharmaceutical preparations for use in the endoscopic diagnostic evaluation; pharmaceutical compositions for use in endoscopy; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes, namely, for enhancing visualization during colonoscopy; dyes for pharmaceutical, medical, surgical and medical diagnostic purposes, namely, for enhancing visualization during colonoscopy. Medical devices for use in chromoendoscopy and endoscopy procedures of the gastrointestinal tract; medical devices to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; medical instruments to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; medical devices for enhancing visualization during chromoendoscopy, endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy procedures; medical devices for introducing compositions containing dye into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; medical devices made with dye for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy and for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical and surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes; pharmaceutical preparations for use in the endoscopic diagnostic evaluation; pharmaceutical compositions for use in endoscopy; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes, namely, for enhancing visualization during colonoscopy; dyes for pharmaceutical, medical, surgical and medical diagnostic purposes, namely, for enhancing visualization during colonoscopy Medical devices for use in chromoendoscopy and endoscopy procedures of the gastrointestinal tract; medical devices to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; medical instruments to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; medical devices for enhancing visualization during chromoendoscopy, endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy procedures; medical devices for introducing compositions containing dye into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; medical devices made with dye for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions for pharmaceutical, medical, surgical and medical diagnostic purposes
Oral pharmaceutical compositions containing rifamycin SV, or a pharmaceutically salt thereof, characterized in that they are formulated in a higher strength (about 600 mg/tablet) and in such a manner to obtain a modified profile of the rifamycin SV, or a pharmaceutically acceptable salt thereof, in the proximal portion of the intestine, i.e. in the small intestine (duodenum, jejunum and ileum). In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of small intestine bacterial overgrowth (SIBO) and/or irritable bowel syndrome (IBS) and/or in the treatment of cholera. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of hepatic encephalopathy, hepatic cirrhosis, pouchitis and/or spontaneous bacterial perotinitis. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of non-alcoholic fatty liver disease, non-alcoholic fatty liver or non-alcoholic steatohepatitis.
The present invention relates to certain cortexolone derivatives of formula (I)
and the use of the same as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. The present invention also relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of the pharmaceutical compositions as antitumor medicinal products.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
C07J 5/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone, p. ex. prégnane, et substitués en position 21 par seulement une unique liaison carbone-oxygène
15.
SOLID ORAL COMPOSITION CONTAINING DYES FOR USE IN ENDOSCOPIC DIAGNOSIS
The present disclosure relates to an (in situ gelling) enema containing Rifamycin SV and its use in the treatment of pouchitis, proctitis and/or distal ulcerative colitis (including proctosigmoiditis). More particularly, the present disclosure describes an in situ gelling retentive enema containing Rifamycin SV for treating, ameliorating, reducing the severity of or slowing the progression of pouchitis, proctitis and/or distal ulcerative colitis (including proctosigmoiditis).
The present disclosure relates to an (in situ gelling) enema containing Rifamycin SV and its use in the treatment of pouchitis, proctitis and/or distal ulcerative colitis (including proctosigmoiditis). More particularly, the present disclosure describes an in situ gelling retentive enema containing Rifamycin SV for treating, ameliorating, reducing the severity of or slowing the progression of pouchitis, proctitis and/or distal ulcerative colitis (including proctosigmoiditis).
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical and veterinary preparations for treatment within the fields of gastroenterology, dermatology, oncology, immune therapy, immunology, gastro retentive drug delivery systems and vaccines; Dietetic substances and food adapted for medical or veterinary use, food for babies; Dietetic supplements for human and animal consumption; Material for stopping teeth, dental wax; none of the aforesaid goods relating to the treatment of iron deficiency or iron deficiency anaemia. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; Suture materials. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical and veterinary preparations for treatment within the fields of gastroenterology, dermatology, oncology, immune therapy, immunology, gastro retentive drug delivery systems and vaccines; Dietetic substances and food adapted for medical or veterinary use, food for babies; Dietetic supplements for human and animal consumption; Material for stopping teeth, dental wax; none of the aforesaid goods relating to the treatment of iron deficiency or iron deficiency anaemia. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; Suture materials. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software.
20.
17α-monoesters and 17α,21-diesters of cortexolone for use in the treatment of tumors
The present invention relates to certain cortexolone derivatives of formula (I)
and the use of the same as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. The present invention also relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of the pharmaceutical compositions as antitumor medicinal products.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
C07J 5/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone, p. ex. prégnane, et substitués en position 21 par seulement une unique liaison carbone-oxygène
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy; Diagnostic agents, preparations and substances for medical purposes, namely, the visualization of colonic polyps, adenomas, carcinomas, early stage cancers and other lesions in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), those with previous history of polyps, adenomas, carcinomas, early stage cancers and other lesions, patients with colorectal cancer and patients with relevant family history; Diagnostic reagents and coloring agent for medical and surgical use; Coloring agent for use with imaging medical equipment; Coloring agent for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and polyps, adenomas, carcinomas, early stage cancers and other lesions thereon; pharmaceutical preparations for use in endoscopic or colonoscopic diagnostic evaluation; pharmaceutical preparations for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions during gastrointestinal endoscopic procedures; pharmaceutical preparations for use in gastroenterology for colon and digestive system health and regulation; pharmaceutical preparations for use in endoscopy of the gastrointestinal tract; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention and treatment related to the gastrointestinal field; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention and treatment related to the gastrointestinal endoscopy field; pharmaceutical preparations to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; pharmaceutical preparations, namely, coloring agent for use in endoscopic procedures; pharmaceutical compositions, namely, coloring agent for use in endoscopy; pharmaceutical preparations for use as reagents for medical use; pharmaceutical preparations, namely, coloring agent for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for enhancing visualization during endoscopic procedures; pharmaceutical preparations containing dyes for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue coloring agent for pharmaceutical, medical and surgical purposes; pharmaceutical preparations containing coloring agent dye for pharmaceutical, medical and surgical purposes; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes. Medical devices for use in endoscopic procedures of the gastrointestinal tract; Medical devices to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; Medical instruments to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; Medical devices for enhancing visualization during endoscopic procedures; Medical devices for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for introducing compositions containing methylene blue into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices for introducing compositions containing dye into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with methylene blue for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with dye for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for use in endoscopy of the gastrointestinal tract.
The invention provides a composition for use as a delivery vehicle comprising at least one thermo-responsive polymer (polymer A) and at least one ion-sensitive polymer (polymer B) in a liquid formulation. Polymer A is preferably a polyoxyethylene-polyoxypropylene block copolymer or a cellulose derivative. Polymer B a polysaccharide. The composition can include an active substance for delivery or can be used as a delivery vehicle for a substance added at the time of administration such as mesenchymal stem cells.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
The present invention provides an innovative combination of biomaterials, multifunctional polymers, able to structure themselves at the site of action. The innovative combination of biomaterials of the invention is formulated in a solid composition and can be used as a versatile delivery vehicle or carrier in many pharmaceutical fields. The solid composition comprising the combination of biomaterials of the invention is provided to target delivery for medical purposes in humans.
Oral pharmaceutical compositions containing rifamycin SV, or a pharmaceutically salt thereof, characterized in that they are formulated in a higher strength (about 600 mg/tablet) and in such a manner to obtain a modified profile of the rifamycin SV, or a pharmaceutically acceptable salt thereof, in the proximal portion of the intestine, i.e. in the small intestine (duodenum, jejunum and ileum). In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of small intestine bacterial overgrowth (SIBO) and/or irritable bowel syndrome (IBS) and/or in the treatment of cholera. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of hepatic encephalopathy, hepatic cirrhosis, pouchitis and/or spontaneous bacterial perotinitis. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of non-alcoholic fatty liver disease, non-alcoholic fatty liver or non-alcoholic steatohepatitis.
The present invention relates to certain cortexolone derivatives of formula (I)
and the use of the same as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. The present invention also relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of the pharmaceutical compositions as antitumor medicinal products.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
C07J 5/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone, p. ex. prégnane, et substitués en position 21 par seulement une unique liaison carbone-oxygène
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Contrast media for use with medical equipment or in medical imaging; Diagnostic agents and reagents for medical use; Diagnostic preparations; Pharmaceutical preparations and substances; Pharmaceutical preparations for treating gastrointestinal disorders, gastrointestinal diseases or digestive system disorders; Non-prescription medicines; Gastroenteric preparations; diagnostic agents, preparations and substances for medical purposes, namely, the visual enhancing or visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; contrast media for medical and surgical use; contrast media for use with gastroscopic, endoscopic, colonoscopic, sigmoidoscopic, anoscopic, rectoscopic and proctoscopic equipment; pharmaceutical preparations to aid the detection, diagnosis, prevention or treatment of gastroenterological diseases; pharmaceutical preparations for use in gastroenterology, endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue or dye for visual enhancing or visualization during endoscopic procedures; pharmaceutical preparations containing methylene blue or dye for pharmaceutical, medical and surgical purposes; methylene blue or dye for pharmaceutical, medical, surgical and medical diagnostic purposes; pharmaceutical preparations for the diagnosis, prevention or treatment of ulcerative colitis or inflammatory bowel diseases; pharmaceutical preparations for the treatment of fertility, reproductive health, hematology, urology, gynecology, obstetrics, endocrinology, oncology, renalology, immunology and inflammatory diseases, disorders and conditions; pharmaceutical preparations for colon and digestive system health and regulation, for improving energy levels or for maintaining and improving mucous levels and the mucosal lining of the intestines and colon; diarrhea medication; anti-nauseants; antiemetic preparations; antibiotic preparations; pharmaceutical preparations for the treatment or prevention of travellers' diarrhea, diarrhea, diverticular disease, diverticulitis or infectious colitis. Providing health care information by the internet; pharmaceutical advice; providing information relating to diagnostic, prophylactic and therapeutic properties of pharmaceuticals.
27.
Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection
The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, preferably said endoscopic procedure comprising the administration of said pharmaceutical composition to a human with the aim of improving and facilitating the resection of the lesion by raising the area where the lesion is located. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human.
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 24/04 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
A61B 1/018 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments caractérisés par les conduits internes ou par leurs accessoires destinés à recevoir des instruments
A61B 1/273 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour l'appareil digestif supérieur, p. ex. œsophagoscopes, gastroscopes
A61J 1/05 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques pour recueillir, stocker ou administrer du sang, du plasma ou des liquides à usage médical
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/195 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 31/205 - Sels d'addition d'acides organiques avec des aminesSels d'ammonium quaternaire internes, p. ex. bétaïne, carnitine
A61K 31/221 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine avec des composés ayant un groupe amino, p. ex. acétylcholine, acétylcarnitine
A61K 31/606 - Acide salicyliqueSes dérivés ayant des groupes amino
The invention provides a composition for use as a delivery vehicle comprising at least one thermo- responsive polymer (polymer A) and at least one ion-sensitive polymer (polymer B)in a liquid formulation. Polymer A is preferably a polyoxyethylene-polyoxypropylene block copolymer or a cellulose derivative. Polymer B apolysaccharide. The composition can include an active substance for delivery or can be used as a delivery vehicle for a substance added at the time of administration such as mesenchymal stem cells.
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 31/395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée
A61K 36/00 - Préparations médicinales de constitution indéterminée contenant du matériel provenant d'algues, de lichens, de champignons, ou de plantes, ou leurs dérivés, p. ex. médicaments traditionnels à base de plantes
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 36/064 - Saccharomycetales, p. ex. levure de boulanger
A61K 36/77 - Sapindaceae (famille du savonnier), p. ex. litchi ou savonnier
The present invention provides an innovative combination of biomaterials, multifunctional polymers, able to structure themselves at the site of action.The innovative combination of biomaterials of the invention is formulated in a solid composition and can be used as a versatile delivery vehicle or carrier in many pharmaceutical fields. The solid composition comprising the combination of biomaterials of the invention is provided to target delivery for medical purposes in humans.
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
The present invention provides an innovative combination of biomaterials, multifunctional polymers, able to structure themselves at the site of action.The innovative combination of biomaterials of the invention is formulated in a solid composition and can be used as a versatile delivery vehicle or carrier in many pharmaceutical fields. The solid composition comprising the combination of biomaterials of the invention is provided to target delivery for medical purposes in humans.
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
The invention provides a composition for use as a delivery vehicle comprising at least one thermo- responsive polymer (polymer A) and at least one ion-sensitive polymer (polymer B)in a liquid formulation. Polymer A is preferably a polyoxyethylene-polyoxypropylene block copolymer or a cellulose derivative. Polymer B apolysaccharide. The composition can include an active substance for delivery or can be used as a delivery vehicle for a substance added at the time of administration such as mesenchymal stem cells.
A61K 47/30 - Composés macromoléculaires organiques ou inorganiques, p. ex. polyphosphates inorganiques
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
Oral pharmaceutical compositions containing rifamycin SV, or a pharmaceutically salt thereof, characterized in that they are formulated in a higher strength (about 600 mg/tablet) and in such a manner to obtain a modified profile of the rifamycin SV, or a pharmaceutically acceptable salt thereof, in the proximal portion of the intestine, i.e. in the small intestine (duodenum, jejunum and ileum). In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of small intestine bacterial overgrowth (SIBO) and/or irritable bowel syndrome (IBS) and/or in the treatment of cholera. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of hepatic encephalopathy, hepatic cirrhosis, pouchitis and/or spontaneous bacterial perotinitis. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of non- alcoholic fatty liver disease, non-alcoholic fatty liver or non-alcoholic steatohepatitis.
Oral pharmaceutical compositions containing rifamycin SV, or a pharmaceutically salt thereof, characterized in that they are formulated in a higher strength (about 600 mg/tablet) and in such a manner to obtain a modified profile of the rifamycin SV, or a pharmaceutically acceptable salt thereof, in the proximal portion of the intestine, i.e. in the small intestine (duodenum, jejunum and ileum). In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of small intestine bacterial overgrowth (SIBO) and/or irritable bowel syndrome (IBS) and/or in the treatment of cholera. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of hepatic encephalopathy, hepatic cirrhosis, pouchitis and/or spontaneous bacterial perotinitis. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of non- alcoholic fatty liver disease, non-alcoholic fatty liver or non-alcoholic steatohepatitis.
The present invention relates to certain cortexolone derivatives of formula (I)
and the use of the same as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. The present invention also relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of the pharmaceutical compositions as antitumor medicinal products.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
C07J 5/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone, p. ex. prégnane, et substitués en position 21 par seulement une unique liaison carbone-oxygène
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
37.
Controlled release and taste masking oral pharmaceutical composition
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/195 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 31/205 - Sels d'addition d'acides organiques avec des aminesSels d'ammonium quaternaire internes, p. ex. bétaïne, carnitine
A61K 31/221 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine avec des composés ayant un groupe amino, p. ex. acétylcholine, acétylcarnitine
A61K 31/606 - Acide salicyliqueSes dérivés ayant des groupes amino
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Diagnostic agents, preparations and substances for medical and surgical purposes, namely, the visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy; Diagnostic agents, preparations and substances for medical purposes, namely, the visualization of colonic polyps, adenomas, carcinomas, early stage cancers and other lesions in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), those with previous history of polyps, adenomas, carcinomas, early stage cancers and other lesions, patients with colorectal cancer and patients with relevant family history; Diagnostic reagents and contrast media for medical and surgical use, namely, the visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and polyps, adenomas, carcinomas, early stage cancers and other lesions thereon; pharmaceutical preparations for use in endoscopic or colonoscopic diagnostic evaluation; pharmaceutical preparations for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions during gastrointestinal endoscopic procedures; pharmaceutical preparations for use in gastroenterology for colon and digestive system health and regulation; pharmaceutical preparations for use in endoscopy of the gastrointestinal tract; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention or treatment related to the gastro-intestinal field; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention or treatment related to the gastrointestinal endoscopy field; pharmaceutical preparations to aid the detection, diagnosis, prevention or treatment of gastroenterological diseases; pharmaceutical preparations for use in endoscopic procedures; pharmaceutical compositions for use in endoscopy; pharmaceutical preparations for use as reagents for medical use, namely enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations for aiding visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for enhancing visualization during endoscopic procedures; pharmaceutical preparations containing dyes for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for pharmaceutical, medical and surgical purposes; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes.
(2) Medical devices for use in endoscopic procedures of the gastrointestinal tract; Medical devices to aid the detection, diagnosis, prevention or treatment of gastroenterological diseases; Medical instruments to aid the detection, diagnosis, prevention or treatment of gastroenterological diseases; Medical devices for enhancing visualization during endoscopic procedures; Medical devices for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for introducing compositions containing methylene blue into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices for introducing compositions containing dye into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with dye for pharmaceutical, medical, surgical and medical diagnostic purposes, namely visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for use in endoscopy of the gastrointestinal tract.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy; Diagnostic agents, preparations and substances for medical purposes, namely, the visualization of colonic polyps, adenomas, carcinomas, early stage cancers and other lesions in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), those with previous history of polyps, adenomas, carcinomas, early stage cancers and other lesions, patients with colorectal cancer and patients with relevant family history; Diagnostic reagents and coloring agent for medical and surgical use; Coloring agent for use with imaging medical equipment; Coloring agent for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and polyps, adenomas, carcinomas, early stage cancers and other lesions thereon; pharmaceutical preparations for use in endoscopic or colonoscopic diagnostic evaluation; pharmaceutical preparations for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions during gastrointestinal endoscopic procedures; pharmaceutical preparations for use in gastroenterology for colon and digestive system health and regulation; pharmaceutical preparations for use in endoscopy of the gastrointestinal tract; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention and treatment related to the gastrointestinal field; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention and treatment related to the gastrointestinal endoscopy field; pharmaceutical preparations to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; pharmaceutical preparations, namely, coloring agent for use in endoscopic procedures; pharmaceutical compositions, namely, coloring agent for use in endoscopy; pharmaceutical preparations for use as reagents for medical use; pharmaceutical preparations, namely, coloring agent for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for enhancing visualization during endoscopic procedures; pharmaceutical preparations containing dyes for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue coloring agent for pharmaceutical, medical and surgical purposes; pharmaceutical preparations containing coloring agent dye for pharmaceutical, medical and surgical purposes; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes Medical devices for use in endoscopic procedures of the gastrointestinal tract; Medical devices to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; Medical instruments to aid the detection, diagnosis, prevention and treatment of gastroenterological diseases; Medical devices for enhancing visualization during endoscopic procedures; Medical devices for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for introducing compositions containing methylene blue into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices for introducing compositions containing dye into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with methylene blue for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with dye for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for use in endoscopy of the gastrointestinal tract
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Diagnostic agents, preparations and substances for medical and surgical purposes, namely, the visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy; Diagnostic agents, preparations and substances for medical purposes, namely, the visualization of colonic polyps, adenomas, carcinomas, early stage cancers and other lesions in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), those with previous history of polyps, adenomas, carcinomas, early stage cancers and other lesions, patients with colorectal cancer and patients with relevant family history; Diagnostic reagents and contrast media for medical and surgical use, namely, the visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and polyps, adenomas, carcinomas, early stage cancers and other lesions thereon; pharmaceutical preparations for use in endoscopic or colonoscopic diagnostic evaluation; pharmaceutical preparations for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions during gastrointestinal endoscopic procedures; pharmaceutical preparations for use in gastroenterology for colon and digestive system health and regulation; pharmaceutical preparations for use in endoscopy of the gastrointestinal tract; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention or treatment related to the gastro-intestinal field; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention or treatment related to the gastrointestinal endoscopy field; pharmaceutical preparations to aid the detection, diagnosis, prevention or treatment of gastroenterological diseases; pharmaceutical preparations for use in endoscopic procedures; pharmaceutical compositions for use in endoscopy; pharmaceutical preparations for use as reagents for medical use, namely enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations for aiding visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for enhancing visualization during endoscopic procedures; pharmaceutical preparations containing dyes for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for pharmaceutical, medical and surgical purposes; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes.
(2) Medical devices for use in endoscopic procedures of the gastrointestinal tract; Medical devices to aid the detection, diagnosis, prevention or treatment of gastroenterological diseases; Medical instruments to aid the detection, diagnosis, prevention or treatment of gastroenterological diseases; Medical devices for enhancing visualization during endoscopic procedures; Medical devices for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for introducing compositions containing methylene blue into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices for introducing compositions containing dye into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with dye for pharmaceutical, medical, surgical and medical diagnostic purposes, namely visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for use in endoscopy of the gastrointestinal tract.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the visual enhancing of polyps, adenomas, carcinomas, early stage cancers and other lesions in the colon for patients undergoing colonoscopy; Diagnostic agents, preparations and substances for medical purposes, namely, the visualization of colonic polyps, adenomas, carcinomas, early stage cancers and other lesions in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), those with previous history of polyps, adenomas, carcinomas, early stage cancers and other lesions, patients with colorectal cancer and patients with relevant family history; Diagnostic reagents and contrast media for medical and surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and polyps, adenomas, carcinomas, early stage cancers and other lesions thereon; pharmaceutical preparations for use in endoscopic or colonoscopic diagnostic evaluation; pharmaceutical preparations for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions during gastrointestinal endoscopic procedures; pharmaceutical preparations for use in gastroenterology for colon and digestive system health and regulation; pharmaceutical preparations for use in endoscopy of the gastrointestinal tract; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention or treatment related to the gastro-intestinal field; pharmaceutical preparations and preparations aiding detection, diagnosis, prevention or treatment related to the gastrointestinal endoscopy field; pharmaceutical preparations to aid the detection, diagnosis, prevention or treatment of gastroenterological diseases; pharmaceutical preparations for use in endoscopic procedures; pharmaceutical compositions for use in endoscopy; pharmaceutical preparations for use as reagents for medical use; pharmaceutical preparations for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for enhancing visualization during endoscopic procedures; pharmaceutical preparations containing dyes for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for pharmaceutical, medical and surgical purposes; pharmaceutical preparations containing dye for pharmaceutical, medical and surgical purposes; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes. Medical devices for use in endoscopic procedures of the gastrointestinal tract; Medical devices to aid the detection, diagnosis, prevention or treatment of gastroenterological diseases; Medical instruments to aid the detection, diagnosis, prevention or treatment of gastroenterological diseases; Medical devices for enhancing visualization during endoscopic procedures; Medical devices for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for introducing compositions containing methylene blue into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices for introducing compositions containing dye into the human body for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices made with dye for pharmaceutical, medical, surgical and medical diagnostic purposes; Medical devices for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; Medical devices for use in endoscopy of the gastrointestinal tract.
The present invention relates to methods for improving the detection of pathologies in the colon and method of flagging the mucosal lesions in the colon.
The present invention relates to methods for improving the detection of pathologies in the colon and method of flagging the mucosal lesions in the colon.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in gastrointestinal endoscopic procedures for submucosal lift of polyps, adenomas, early-stage cancers, and other lesions; pharmaceutical preparations for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions during gastrointestinal endoscopic procedures; pharmaceutical preparations for use in gastroenterology for colon and digestive system health and regulation; pharmaceutical preparations for use in endoscopy of the gastrointestinal tract; pharmaceutical preparations and preparations aiding diagnosis related to the gastro-intestinal field; pharmaceutical preparations and preparations aiding diagnosis related to the gastrointestinal endoscopy field; pharmaceutical preparations to aid diagnosis, prevention and treatment of gastroenterological diseases; pharmaceutical preparations for use in endoscopic procedures; pharmaceutical compositions for use in endoscopy; pharmaceutical preparations for use in endoscopic resections and endoscopic dissection of polyps, adenomas, carcinomas, early stage cancers and other lesions; pharmaceutical preparations for forming submucosal cushions in endoscopic procedures; pharmaceutical preparations for use as reagents for medical use; pharmaceutical preparations for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; liquid pharmaceutical compositions in the form of emulsion for use in endoscopic procedures; liquid pharmaceutical compositions in the form of micro-emulsion for use in endoscopic procedures; liquid pharmaceutical preparations, namely, submucosal injectable compositions for use in endoscopic procedures; liquid pharmaceutical preparations namely, emulsions for use in endoscopic procedures; liquid pharmaceutical preparations, namely, micro-emulsions for use in endoscopic procedures; liquid pharmaceutical preparations for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for enhancing visualization during endoscopic procedures; pharmaceutical preparations containing dyes for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy.
(2) Injection syringes (syringe barrels); ampoules; ampoules for medical purposes; endoscopic equipment for medical purposes; gastroscopes; catheters; syringes for medical purposes; surgical probes; medical and surgical catheters; injection needles; injection instruments without needles; disposable syringes; pre-filled syringes; ampoules containing submucosal injectable compositions for use in endoscopic procedures; ampoules containing emulsion for use in endoscopic procedures; ampoules containing micro-emulsion for use in endoscopic procedures; ampoules containing submucosal injectable compositions for use in endoscopic resections and endoscopic dissection of polyps, adenomas, carcinomas, early stage cancers and other lesions; pre-filled syringes containing submucosal injectable compositions for use in endoscopic procedures; pre-filled syringes containing emulsion for use in endoscopic procedures; pre-filled syringes containing microemulsion for use in endoscopic procedures; pre-filled syringes containing submucosal injectable compositions for use in endoscopic resections and endoscopic dissection of polyps, adenomas, carcinomas, early stage cancers and other lesions; Medical devices for use in endoscopy, namely endoscopic equipment; Medical devices for introducing emulsions and mico-emulsions into the human body, namely injection syringes; Medical devices for use in enhancing visualization prior to or during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy, namely, endoscopic equipment, colonoscopic equipment, sigmoidoscopic equipment, anoscopic equipment, rectoscopic equipment and proctoscopic equipment; Medical devices in the nature of ampoules and pre-filled syringes for introducing compositions containing methylene blue into the human body for pharmaceutical, medical, surgical and medical purposes; Medical devices in the nature of ampoules and pre-filled syringes for introducing compositions containing dye into the human body for pharmaceutical, medical, surgical and medical purposes.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Enema preparations; enema preparations for rectal administration containing a dye for cleansing; enema preparations for rectal administration containing a dye for coloring; enema preparations, namely, liquid compositions in form of emulsion or microemulsion; enema preparations for subjects undergoing an endoscopic procedure of sigmoid colon and/or rectum; enema preparations for subjects undergoing endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy or proctoscopy; emulsions and microemulsions namely, liquid compositions in the form of emulsions and microemulsions for rectal administration containing a dye for cleansing; emulsions and microemulsions for medical purposes, namely, liquid compositions in the form of emulsions and microemulsions for rectal administration containing a dye for coloring; emulsions and microemulsions for rectal administration containing a dye for cleansing; pharmaceutical preparations for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; enema preparations for cleansing the sigmoid colon prior to diagnostic procedures; enema preparations for cleansing the rectum prior to diagnostic procedures; enema preparations for coloring the sigmoid colon prior to diagnostic procedures; enema preparations for coloring the rectum prior to diagnostic procedures; enema preparations for cleansing of the intestine, the colon, sigma and rectum; enema preparations for the coloring of the intestine, the colon, sigma and rectum; liquid pharmaceutical preparations, namely, emulsions for use prior to endoscopic diagnostic procedures; liquid pharmaceutical preparations, namely, micro-emulsions for use prior to endoscopic diagnostic procedures; Liquid pharmaceutical compositions in the form of emulsion for use in endoscopic procedures; liquid pharmaceutical compositions in the form of micro-emulsion for use in endoscopic procedures; Enema preparations containing methylene blue for enhancing visualization prior to or during endoscopic procedures; enema preparations containing dyes for enhancing visualization prior to or during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; enema preparations containing methylene blue for pharmaceutical, medical, surgical and diagnostic purposes; enema preparations containing dye for pharmaceutical, medical, surgical and diagnostic purposes; Laxatives; bowel cleansing preparations; pharmaceutical preparations namely, rectal suppositories; bowel cleansing preparation kits consisting of laxative solutions and tablets, enemas and suppositories; solutions used as a laxative and purgative for the treatment of constipation and gastro-intestinal disturbances; Pharmaceutical preparations for treating bowel disorders; Stool softeners.
(2) Enema syringes; Enema kits; Enema apparatus for medical purposes; Enema apparatus prefilled with an enema preparation; Rectal instruments; Rectal instruments, namely, medical instruments for use in rectal endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy procedures; Rectal medical apparatus, namely, enema preparation delivery devices for rectal administration of emulsions; Rectal medical apparatus, namely, enema preparation delivery devices for rectal administration of microemulsions; Enema syringes; Enema kits; Enema apparatus for medical purposes; Enema apparatus prefilled with an enema preparation; Rectal instruments; Rectal instruments, namely, medical instruments for use in rectal endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy procedures; Rectal medical apparatus, namely, enema preparation delivery devices for rectal administration of emulsions; Rectal medical apparatus, namely, enema preparation delivery devices for rectal administration of microemulsions; Medical devices for use in endoscopy, namely endoscopic equipment; Medical devices for introducing emulsions and mico-emulsions into the human body, namely injection syringes; Medical devices for use in enhancing visualization prior to or during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy, namely, endoscopic equipment, colonoscopic equipment, sigmoidoscopic equipment, anoscopic equipment, rectoscopic equipment and proctoscopic equipment; Injection syringes (syringe barrels); Gastroscopes; Catheters; Urethral probe syringes; Syringes for medical purposes; Surgical instruments; Surgical probes ; Medical and surgical catheters; Injection instruments without needles; Injection syringes (syringe barrels); Gastroscopes; Catheters; Urethral probe syringes; Syringes for medical purposes; Surgical instruments; Surgical probes ; Medical and surgical catheters; Injection instruments without needles.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Enema preparations; enema preparations for rectal administration containing a dye for cleansing; enema preparations for rectal administration containing a dye for coloring; enema preparations, namely, liquid compositions in form of emulsion or microemulsion; enema preparations for subjects undergoing an endoscopic procedure of sigmoid colon and/or rectum; enema preparations for subjects undergoing endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy or proctoscopy; emulsions and microemulsions namely, liquid compositions in the form of emulsions and microemulsions for rectal administration containing a dye for cleansing; emulsions and microemulsions for medical purposes, namely, liquid compositions in the form of emulsions and microemulsions for rectal administration containing a dye for coloring; emulsions and microemulsions for rectal administration containing a dye for cleansing; pharmaceutical preparations for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; enema preparations for cleansing the sigmoid colon prior to diagnostic procedures; enema preparations for cleansing the rectum prior to diagnostic procedures; enema preparations for coloring the sigmoid colon prior to diagnostic procedures; enema preparations for coloring the rectum prior to diagnostic procedures; enema preparations for cleansing of the intestine, the colon, sigma and rectum; enema preparations for the coloring of the intestine, the colon, sigma and rectum; liquid pharmaceutical preparations, namely, emulsions for use prior to endoscopic diagnostic procedures; liquid pharmaceutical preparations, namely, micro-emulsions for use prior to endoscopic diagnostic procedures; Liquid pharmaceutical compositions in the form of emulsion for use in endoscopic procedures; liquid pharmaceutical compositions in the form of micro-emulsion for use in endoscopic procedures; Enema preparations containing methylene blue for enhancing visualization prior to or during endoscopic procedures; enema preparations containing dyes for enhancing visualization prior to or during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; enema preparations containing methylene blue for pharmaceutical, medical, surgical and diagnostic purposes; enema preparations containing dye for pharmaceutical, medical, surgical and diagnostic purposes; Laxatives; bowel cleansing preparations; pharmaceutical preparations namely, rectal suppositories; bowel cleansing preparation kits consisting of laxative solutions and tablets, enemas and suppositories; solutions used as a laxative and purgative for the treatment of constipation and gastro-intestinal disturbances; Pharmaceutical preparations for treating bowel disorders; Stool softeners.
(2) Enema syringes; Enema kits; Enema apparatus for medical purposes; Enema apparatus prefilled with an enema preparation; Rectal instruments; Rectal instruments, namely, medical instruments for use in rectal endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy procedures; Rectal medical apparatus, namely, enema preparation delivery devices for rectal administration of emulsions; Rectal medical apparatus, namely, enema preparation delivery devices for rectal administration of microemulsions; Enema syringes; Enema kits; Enema apparatus for medical purposes; Enema apparatus prefilled with an enema preparation; Rectal instruments; Rectal instruments, namely, medical instruments for use in rectal endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy procedures; Rectal medical apparatus, namely, enema preparation delivery devices for rectal administration of emulsions; Rectal medical apparatus, namely, enema preparation delivery devices for rectal administration of microemulsions; Medical devices for use in endoscopy, namely endoscopic equipment; Medical devices for introducing emulsions and mico-emulsions into the human body, namely injection syringes; Medical devices for use in enhancing visualization prior to or during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy, namely, endoscopic equipment, colonoscopic equipment, sigmoidoscopic equipment, anoscopic equipment, rectoscopic equipment and proctoscopic equipment; Injection syringes (syringe barrels); Gastroscopes; Catheters; Urethral probe syringes; Syringes for medical purposes; Surgical instruments; Surgical probes ; Medical and surgical catheters; Injection instruments without needles; Injection syringes (syringe barrels); Gastroscopes; Catheters; Urethral probe syringes; Syringes for medical purposes; Surgical instruments; Surgical probes ; Medical and surgical catheters; Injection instruments without needles.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in gastrointestinal endoscopic procedures for submucosal lift of polyps, adenomas, early-stage cancers, and other lesions; pharmaceutical preparations for enhancing visualization of polyps, adenomas, carcinomas, early stage cancers and other lesions during gastrointestinal endoscopic procedures; pharmaceutical preparations for use in gastroenterology for colon and digestive system health and regulation; pharmaceutical preparations for use in endoscopy of the gastrointestinal tract; pharmaceutical preparations and preparations aiding diagnosis related to the gastro-intestinal field; pharmaceutical preparations and preparations aiding diagnosis related to the gastrointestinal endoscopy field; pharmaceutical preparations to aid diagnosis, prevention and treatment of gastroenterological diseases; pharmaceutical preparations for use in endoscopic procedures; pharmaceutical compositions for use in endoscopy; pharmaceutical preparations for use in endoscopic resections and endoscopic dissection of polyps, adenomas, carcinomas, early stage cancers and other lesions; pharmaceutical preparations for forming submucosal cushions in endoscopic procedures; pharmaceutical preparations for use as reagents for medical use; pharmaceutical preparations for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; liquid pharmaceutical compositions in the form of emulsion for use in endoscopic procedures; liquid pharmaceutical compositions in the form of micro-emulsion for use in endoscopic procedures; liquid pharmaceutical preparations, namely, submucosal injectable compositions for use in endoscopic procedures; liquid pharmaceutical preparations namely, emulsions for use in endoscopic procedures; liquid pharmaceutical preparations, namely, micro-emulsions for use in endoscopic procedures; liquid pharmaceutical preparations for use in endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy; pharmaceutical preparations containing methylene blue for enhancing visualization during endoscopic procedures; pharmaceutical preparations containing dyes for enhancing visualization during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy.
(2) Injection syringes (syringe barrels); ampoules; ampoules for medical purposes; endoscopic equipment for medical purposes; gastroscopes; catheters; syringes for medical purposes; surgical probes; medical and surgical catheters; injection needles; injection instruments without needles; disposable syringes; pre-filled syringes; ampoules containing submucosal injectable compositions for use in endoscopic procedures; ampoules containing emulsion for use in endoscopic procedures; ampoules containing micro-emulsion for use in endoscopic procedures; ampoules containing submucosal injectable compositions for use in endoscopic resections and endoscopic dissection of polyps, adenomas, carcinomas, early stage cancers and other lesions; pre-filled syringes containing submucosal injectable compositions for use in endoscopic procedures; pre-filled syringes containing emulsion for use in endoscopic procedures; pre-filled syringes containing microemulsion for use in endoscopic procedures; pre-filled syringes containing submucosal injectable compositions for use in endoscopic resections and endoscopic dissection of polyps, adenomas, carcinomas, early stage cancers and other lesions; Medical devices for use in endoscopy, namely endoscopic equipment; Medical devices for introducing emulsions and mico-emulsions into the human body, namely injection syringes; Medical devices for use in enhancing visualization prior to or during endoscopy, colonoscopy, sigmoidoscopy, anoscopy, rectoscopy and proctoscopy, namely, endoscopic equipment, colonoscopic equipment, sigmoidoscopic equipment, anoscopic equipment, rectoscopic equipment and proctoscopic equipment; Medical devices in the nature of ampoules and pre-filled syringes for introducing compositions containing methylene blue into the human body for pharmaceutical, medical, surgical and medical purposes; Medical devices in the nature of ampoules and pre-filled syringes for introducing compositions containing dye into the human body for pharmaceutical, medical, surgical and medical purposes.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for the treatment of travellers' diarrhea, diarrhea, diverticular disease, diverticulitis or infectious colitis; Pharmaceutical preparations for the prevention of travellers' diarrhea, diarrhea, diverticular disease, diverticulitis or infectious colitis; Pharmaceutical preparations and substances for the treatment of gastrointestinal diseases and disorders; Pharmaceutical preparations for the prevention of gastrointestinal diseases and disorders; Pharmaceutical preparations for colon and digestive system health and regulation; Diarrhea medication; Gastro-intestinal treatment preparations; Anti-nauseants; Nausea treatment preparations; Antiemetic preparations; Pharmaceutical agents affecting digestive organs; Antibiotics; Antibiotic preparations
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy and for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical and surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes; pharmaceutical preparations for use in the endoscopic diagnostic evaluation; pharmaceutical compositions for use in endoscopy; methylene blue for enhancing visualization during colonoscopy; dyes for enhancing visualization during colonoscopy
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy and for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical and surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes; pharmaceutical preparations for use in the endoscopic diagnostic evaluation; pharmaceutical compositions for use in endoscopy; methylene blue for enhancing visualization during colonoscopy; dyes for enhancing visualization during colonoscopy.
54.
Cortexolone 17alpha-benzoate for use in the treatment of tumours
The present invention provides certain cortexolone derivatives of formula (I), and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
C07J 5/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone, p. ex. prégnane, et substitués en position 21 par seulement une unique liaison carbone-oxygène
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy and for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical and surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes; pharmaceutical preparations for use in the endoscopic diagnostic evaluation; pharmaceutical compositions for use in endoscopy; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes, namely, for enhancing visualization during colonoscopy; dyes for pharmaceutical, medical, surgical and medical diagnostic purposes, namely, for enhancing visualization during colonoscopy
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy and for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical and surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes; pharmaceutical preparations for use in the endoscopic diagnostic evaluation; pharmaceutical compositions for use in endoscopy; methylene blue for enhancing visualization during colonoscopy; dyes for enhancing visualization during colonoscopy.
57.
Controlled release and taste masking oral pharmaceutical composition
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The present invention provides certain cortexolone derivatives of formula (I) and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
C07J 5/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone, p. ex. prégnane, et substitués en position 21 par seulement une unique liaison carbone-oxygène
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for the treatment of travellers' diarrhea, diarrhea, diverticular disease, diverticulitis or infectious colitis; Pharmaceutical preparations for the prevention of travellers' diarrhea, diarrhea, diverticular disease, diverticulitis or infectious colitis; Pharmaceutical preparations and substances for the treatment of gastrointestinal diseases and disorders; Pharmaceutical preparations for the prevention of gastrointestinal diseases and disorders; Pharmaceutical preparations for colon and digestive system health and regulation; Diarrhea medication; Gastro-intestinal treatment preparations; Anti-nauseants; Nausea treatment preparations; Antiemetic preparations; Pharmaceutical agents affecting digestive organs; Antibiotics; Antibiotic preparations
60.
Controlled release and taste masking oral pharmaceutical composition
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Enema preparations; enema preparations for rectal administration containing a dye for cleansing and coloring the colon; enema preparations, namely a liquid composition in form of emulsion or microemulsion; enema preparations for subjects undergoing an endoscopic procedure of sigmoid colon and/or rectum; a liquid composition in form of emulsion or microemulsion for rectal administration containing a dye for cleansing and coloring the colon; pharmaceutical preparations; pharmaceutical preparations for use in the endoscopic diagnostic evaluation; pharmaceutical compositions; diagnostic preparations for medical purposes; diagnostic reagents for medical use; liquid pharmaceutical compositions in the form of emulsion for use in endoscopic diagnostic scope; liquid pharmaceutical compositions in the form of micro-emulsion for use in endoscopic diagnostic scope; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes. Enema apparatus; Enema syringes; Enema apparatus for medical purposes; Rectal instruments; Endoscopic equipment for medical purposes; Medical apparatus for introducing pharmaceutical preparations into the human body; Medical apparatus for introducing enema preparations into the human body; Medical devices for rectal administration containing a dye for cleansing and coloring the colon; Medical device preparations for subjects undergoing an endoscopic procedure of sigmoid colon and/or rectum; Medical devices for use in the endoscopic diagnostic evaluation; Injection syringes [syringe barrels]; Endoscopic equipment for medical purposes; Syringes for medical purposes; Surgical devices and instruments; Medical apparatus for introducing pharmaceutical preparations into the human body; Disposable syringes.
63.
Liquid composition in the form of emulsion or microemulsion for rectal administration containing at least one dye, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum
The present invention provides a novel liquid composition in the form of an emulsion or microemulsion for rectal administration comprising at least one dye, at least one emulsifier, and at least one physiologically acceptable excipient, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum. Preferably, said diagnostic endoscopic procedure of sigmoid colon and/or rectum is an anoscopy, a proctoscopy, a rectoscopy and/or a sigmoidoscopy.
A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
A61B 1/31 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour le rectum, p. ex. proctoscopes, sigmoïdoscopes
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Enema preparations; enema preparations for rectal administration containing a dye for cleansing and coloring the colon; enema preparations, namely a liquid composition in form of emulsion or microemulsion; enema preparations for subjects undergoing an endoscopic procedure of sigmoid colon and/or rectum; a liquid composition in form of emulsion or microemulsion for rectal administration containing a dye for cleansing and coloring the colon; pharmaceutical preparations; pharmaceutical preparations for use in the endoscopic diagnostic evaluation; pharmaceutical compositions; diagnostic preparations for medical purposes; diagnostic reagents for medical use; liquid pharmaceutical compositions in the form of emulsion for use in endoscopic diagnostic scope; liquid pharmaceutical compositions in the form of micro-emulsion for use in endoscopic diagnostic scope; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes. Enema apparatus; Enema syringes; Enema apparatus for medical purposes; Rectal instruments; Endoscopic equipment for medical purposes; Medical apparatus for introducing pharmaceutical preparations into the human body; Medical apparatus for introducing enema preparations into the human body; Medical devices for rectal administration containing a dye for cleansing and coloring the colon; Medical device preparations for subjects undergoing an endoscopic procedure of sigmoid colon and/or rectum; Medical devices for use in the endoscopic diagnostic evaluation; Injection syringes [syringe barrels]; Endoscopic equipment for medical purposes; Syringes for medical purposes; Surgical devices and instruments; Medical apparatus for introducing pharmaceutical preparations into the human body; Disposable syringes.
65.
Controlled release and taste masking oral pharmaceutical composition
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, said endoscopic procedure preferably comprising the administration of said pharmaceutical composition to a human. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human.
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy and for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical and surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Diagnostic agents, preparations and substances for medical and surgical purposes; Diagnostic agents, preparations and substances for medical purposes, namely, the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy and for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical and surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Diagnostic agents, preparations and substances for medical or surgical purposes; Diagnostic agents, preparations and substances for the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy; Diagnostic agents, preparations and substances for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical or surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Diagnostic agents, preparations and substances for medical or surgical purposes; Diagnostic agents, preparations and substances for the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy; Diagnostic agents, preparations and substances for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical or surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Diagnostic agents, preparations and substances for medical or surgical purposes; Diagnostic agents, preparations and substances for the enhancing of adenomatous, cancerous and other proliferative lesions in the colon for patients undergoing colonoscopy; Diagnostic agents, preparations and substances for the visualization of colonic adenoma in patients undergoing screening colonoscopy including patients at high risk of colorectal carcinoma (CRC), including those with previous history of polyps at prior colonoscopy, patients with colorectal cancer and patients with family history; Diagnostic reagents and contrast media for medical or surgical use; Contrast media for use with imaging medical equipment; Contrast media for use with colonoscopic equipment; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for use in colonoscopy; pharmaceutical preparations for the differentiation of the tissues of the intestines and colon and lesions thereto; pharmaceutical preparations for use in the colonoscopic diagnostic evaluation; methylene blue for pharmaceutical, medical, surgical and medical diagnostic purposes; dye for pharmaceutical, medical, surgical and medical diagnostic purposes.
72.
Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection
The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
A61L 24/04 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for the treatment of travellers' diarrhea, diarrhea, diverticular disease, diverticulitis or infectious colitis; Pharmaceutical preparations for the prevention of travellers' diarrhea, diarrhea, diverticular disease, diverticulitis or infectious colitis; Pharmaceutical preparations and substances for the treatment of gastrointestinal diseases and disorders; Pharmaceutical preparations for the prevention of gastrointestinal diseases and disorders; Pharmaceutical preparations for colon and digestive system health and regulation; Diarrhea medication; Gastro-intestinal treatment preparations; Anti-nauseants; Nausea treatment preparations; Antiemetic preparations; Pharmaceutical agents affecting digestive organs; Antibiotics; Antibiotic preparations
74.
Solid composition for the oral administration of dyes and diagnostic use thereof
The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
A61B 1/31 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour le rectum, p. ex. proctoscopes, sigmoïdoscopes
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61M 31/00 - Dispositifs pour l'introduction ou la rétention d'agents, p. ex. de remèdes, dans les cavités du corps
A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
A61B 1/273 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour l'appareil digestif supérieur, p. ex. œsophagoscopes, gastroscopes
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations for use in gastroenterology, for colon and digestive system health and regulation, for improving energy levels, for the differentiation of the tissues and for maintaining and improving mucous levels and the mucosal lining of the intestines and colon; pharmaceutical preparations for use in the endoscopic diagnostic evaluation mainly related to gastro-intestinal tract and colon; diagnostic preparations for medical purposes; diagnostic reagents for medical use; submucosal injectable compositions for the differentiation of the tissues, namely, a submucosal injection agent for use in endoscopic procedures; liquid pharmaceutical compositions in the form of emulsion for use in endoscopic diagnostic scope, namely, emulsions; liquid pharmaceutical compositions in the form of micro-emulsion for use in endoscopic diagnostic scope, namely, micro-emulsions [ Injection syringes, syringe barrels; endoscopic equipment for medical purposes; gastroscopes; catheters; urethral probe syringes; tubing for use with catheters; syringes for medical purposes; surgical devices and instruments; probes for medical purposes; medical apparatus for introducing pharmaceutical preparations into the human body; medical and surgical catheters; injection needles; injection instruments without needles; disposable syringes ]
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations for use in gastroenterology, for colon and digestive system health and regulation, for improving energy levels, for the differentiation of the tissues and for maintaining and improving mucous levels and the mucosal lining of the intestines and colon; pharmaceutical preparations for use in the endoscopic diagnostic evaluation mainly related to gastro-intestinal tract and colon; diagnostic preparations for medical purposes; diagnostic reagents for medical use; submucosal injectable compositions for the differentiation of the tissues, namely, a submucosal injection agent for use in endoscopic procedures; liquid pharmaceutical compositions in the form of emulsion for use in endoscopic diagnostic scope, namely, emulsions; liquid pharmaceutical compositions in the form of micro-emulsion for use in endoscopic diagnostic scope, namely, micro-emulsions [ Injection syringes, syringe barrels; endoscopic equipment for medical purposes; gastroscopes; catheters; urethral probe syringes; tubing for use with catheters; syringes for medical purposes; surgical devices and instruments; probes for medical purposes; medical apparatus for introducing pharmaceutical preparations into the human body; medical and surgical catheters; injection needles; injection instruments without needles; disposable syringes ]
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations; pharmaceutical preparations for use in the endoscopic diagnostic evaluation mainly related to gastro-intestinal tract and colon; pharmaceutical compositions; diagnostic preparations for medical purposes; diagnostic reagents for medical use; submucosal injectable compositions; liquid pharmaceutical compositions in the form of emulsion for use in endoscopic diagnostic scope; liquid pharmaceutical compositions in the form of micro-emulsion for use in endoscopic diagnostic scope. Injection syringes [syringe barrels]; Endoscopic equipment for medical purposes; Gastroscopes; Catheters; Urethral probe syringes; Tubing for use with catheters; Syringes for medical purposes; Surgical devices and instruments; Probes for medical purposes; Medical apparatus for introducing pharmaceutical preparations into the human body; Medical and surgical catheters; Injection needles; Injection instruments without needles; Disposable syringes.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations; pharmaceutical preparations for use in the endoscopic diagnostic evaluation mainly related to gastro-intestinal tract and colon; pharmaceutical compositions; diagnostic preparations for medical purposes; diagnostic reagents for medical use; submucosal injectable compositions; liquid pharmaceutical compositions in the form of emulsion for use in endoscopic diagnostic scope; liquid pharmaceutical compositions in the form of micro-emulsion for use in endoscopic diagnostic scope. Injection syringes [syringe barrels]; Endoscopic equipment for medical purposes; Gastroscopes; Catheters; Urethral probe syringes; Tubing for use with catheters; Syringes for medical purposes; Surgical devices and instruments; Probes for medical purposes; Medical apparatus for introducing pharmaceutical preparations into the human body; Medical and surgical catheters; Injection needles; Injection instruments without needles; Disposable syringes.
79.
CORTEXOLONE 17ALPHA-BENZOATE FOR USE IN THE TREATMENT OF TUMOURS
The present invention provides certain cortexolone derivatives of formula (I), and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
The present invention provides certain cortexolone derivatives of formula (I) and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 31/4166 - 1,3-Diazoles ayant des groupes oxo liés directement à l'hétérocycle, p. ex. phénytoïne
The present invention provides certain cortexolone derivatives of formula (I) and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
C07J 5/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone, p. ex. prégnane, et substitués en position 21 par seulement une unique liaison carbone-oxygène
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
The present invention provides certain cortexolone derivatives of formula (I) and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
C07J 5/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone, p. ex. prégnane, et substitués en position 21 par seulement une unique liaison carbone-oxygène
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
A61L 24/04 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires
84.
LIQUID COMPOSITION IN THE FORM OF EMULSION OR MICROEMULSION FOR RECTAL ADMINISTRATION CONTAINING AT LEAST ONE DYE, AND ITS USE IN A DIAGNOSTIC ENDOSCOPIC PROCEDURE OF SIGMOID COLON AND/OR RECTUM
The present invention provides a novel liquid composition in the form of an emulsion or microemulsion for rectal administration comprising at least one dye, at least one emulsifier, and at least one physiologically acceptable excipient, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum. Preferably, said diagnostic endoscopic procedure of sigmoid colon and/or rectum is an anoscopy, a proctoscopy, a rectoscopy and/or a sigmoidoscopy.
LIQUID COMPOSITION IN THE FORM OF EMULSION OR MICROEMULSION FOR RECTAL ADMINISTRATION CONTAINING AT LEAST ONE DYE, AND ITS USE IN A DIAGNOSTIC ENDOSCOPIC PROCEDURE OF SIGMOID COLON AND/OR RECTUM
The present invention provides a novel liquid composition in the form of an emulsion or microemulsion for rectal administration comprising at least one dye, at least one emulsifier, and at least one physiologically acceptable excipient, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum. Preferably, said diagnostic endoscopic procedure of sigmoid colon and/or rectum is an anoscopy, a proctoscopy, a rectoscopy and/or a sigmoidoscopy.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical products; dietetic substances adapted for medical use; lactic ferments for pharmaceutical use; biological products and supplements for medical use; dietary foods for medical use; food supplements; dietary supplements; vitamin supplements; nutritional supplements; dietary supplemental drinks; vitamin preparations in the form of food supplements; nutraceutical products for use as dietary supplements; Mineral supplements for human use; medical product based on butyric acid and inulin that contributes to the restoration of intestinal barrier.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations; pharmaceutical preparations for use in the endoscopic diagnostic evaluation mainly related to gastro-intestinal tract and colon; pharmaceutical compositions; diagnostic preparations for medical purposes; diagnostic reagents for medical use.
88.
EMULSIONS OR MICROEMULSIONS FOR USE IN ENDOSCOPIC MUCOSAL RESECTIONING AND/OR ENDOSCOPIC SUBMUCOSAL DISSECTION
The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, preferably said endoscopic procedure comprising the administration of said pharmaceutical composition to a human with the aim of improving and facilitating the resection of the lesion by raising the area where the lesion is located. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human. The invention herein disclosed also provides a kit for use in an endoscopic procedure, said kit comprising a pharmaceutical composition in form of emulsion or microemulsion, an endoscopic injection needle, a syringe and instructions for use thereof.
The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, preferably said endoscopic procedure comprising the administration of said pharmaceutical composition to a human with the aim of improving and facilitating the resection of the lesion by raising the area where the lesion is located. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human. The invention herein disclosed also provides a kit for use in an endoscopic procedure, said kit comprising a pharmaceutical composition in form of emulsion or microemulsion, an endoscopic injection needle, a syringe and instructions for use thereof.
The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, said endoscopic procedure preferably comprising the administration of said pharmaceutical composition to a human. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human.
The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, said endoscopic procedure preferably comprising the administration of said pharmaceutical composition to a human. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human.
The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
93.
Controlled release and taste masking oral pharmaceutical composition
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
A61K 9/26 - Particules distinctes dans une matrice support
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
In a preferred embodiment, there is provided a solid composition comprising a matrix having a lipophilic compound in which a dye is at least partly incorporated; another matrix having a hydrophilic compound in which the lipophilic compound is dispersed; and optionally other physiologically acceptable excipients and a gastro-resistant coating, for use in endoscopic evaluation, wherein four, six or eight unit dosages are for oral administration to deliver 100 to 200 mg of the dye in the 48 hours prior to the endoscopic evaluation, wherein said eight unit dosages each containing 25 mg the dye, said four unit dosages each containing 50 mg of the dye, said six unit dosages each containing 25 mg of the dye, or said four unit dosages each containing 25 mg of the dye are for administration to said human prior to the endoscopic evaluation; and wherein the dye is methylene blue.
The present disclosure relates to methods for treating intestinal diseases presenting at least one inflammatory component such as inflammatory bowel disease or diverticular disease and/or maintaining remission of intestinal diseases presenting at least one inflammatory component such as inflammatory bowel disease (IBD) or diverticular disease using budesonide MMX compositions.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
The invention relates to the use of mexiprostil in the treatment and/or prevention of inflammatory bowel disease and of irritable bowel syndrome, to the combinations of mexiprostil with other drugs, and also to a novel method for the synthesis of mexiprostil.
A61K 31/5575 - Eicosanoïdes, p. ex. leucotriènes ayant un cycle cyclopentane, p. ex. prostaglandine E2, prostaglandine F2-alpha
A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
100.
PHARMACEUTICAL AND/OR DIETARY COMPOSITIONS BASED ON SHORT CHAIN FATTY ACIDS
Pharmaceutical and/or dietary compositions based on short chain fatty acids or salts, esters and/or amides thereof in combination with one or more dietary soluble or water- dispersible fibre and at least one flavouring agent are disclosed.
