The present invention relates to a mesh implantation system in the field of hernia surgery, said system comprising a textile fabric and a tissue adhesive, wherein the textile fabric is composed of a polymer selected from the group comprising or consisting of polyethersulphones, polysulphones, polyolefins, polyesters, fluoropolymers, silicones or mixed polymers and/or mixtures thereof, wherein the system is characterised in that the fabric adhesive is a two-component adhesive having as a first component at least one amino-functional aspartic acid ester acting as a curing agent and having as a second component an isocyanate-functional prepolymer. The invention also relates to: a planar composite material suitable for use as a mesh implant in the field of hernia surgery, obtained or obtainable from the aforementioned system; a method for producing such a planar composite material; and a mesh implantation method in the field of hernia surgery using such a system.
The present invention relates to a layered construction for staunching a bleed or the emission of tissue fluid from a wound, comprising a tissue adhesive layer composed of an at least two-component tissue adhesive system and/or reaction products thereof, and also to a protective liner applied thereto and at least partly covering the tissue adhesive layer, said liner comprising a polymer film that is not nonstick-coated; the tissue adhesive system comprising at least one amino-functional aspartic ester as curing agent with optionally at least one filler as first component, and as second component an isocyanate-functional prepolymer, where the layered construction is characterized in that the polymer component of the polymer film is selected from thermoplastic polymers and the polymer film relative to the cured tissue adhesive system has a peel force in the roller peel test according to DIN EN 1464 – 2010 – 06 of less than 2.5 N/cm. The invention also relates to a method for staunching a bleed or the emission of tissue fluid from a wound, to a kit for such a method, and to the use of a polymer film that is not nonstick-coated as a protective liner for an at least two-component tissue adhesive system.
The invention relates to a metering system (1) for a tissue adhesive system which comprises at least two components, comprising a container which is divided into a first chamber (2) and a second chamber (3) in the longitudinal direction, said container having a rigidly designed shoulder piece (5) in the region of the first chamber (2), which is arranged on the container outlet (4). The first chamber (2) contains a film bag (6) for receiving the first component of the tissue adhesive system, and the remaining cavity of the container body, as the second chamber (3), is designed to receive the second component of the tissue adhesive system and is surrounded by a flexible container casing (7). A guide channel (8) extends from the container outlet (4) into the second chamber (3), and a mixing tube (9) with an inner static mixer is arranged in the guide channel in a longitudinally movable manner. The mixing tube (9) within the guide channel (8) can be pulled out of the container outlet (4) in the longitudinal direction at least to such a degree that an outlet opening (10), which is provided in the guide channel (8) in the region of the first chamber (2), is released in order to bring the first component of the tissue adhesive system into contact with the second component of the tissue adhesive system in the guide channel (8). The invention additionally relates to a kit consisting of a metering system which is filled with a tissue adhesive system comprising at least two components and to a method for closing a wound using such a kit.
The present invention relates to a dosing system (1) having at least two chambers (2, 3) for a fabric adhesive system comprising at least two components. A first chamber (2) takes the form of a hollow cylinder (H) which is closed at one end face (2a) and open at the opposite end face (2b). A second chamber (3) takes the form of an annular gap (4) in a solid cylinder (V), said annular gap extending from an end face (3a) facing the hollow cylinder (H) to a mixing chamber (5) situated at the opposite end (3b) of the solid cylinder (V). A feed channel (6) is provided which extends on the inside of the annular gap (4) in the solid cylinder (V) from the end face (3a) of the solid cylinder (V) facing the hollow cylinder (H) into the mixing chamber (5), wherein a mixing tube (7) protrudes laterally out of the mixing chamber (5) and is arranged displaceably transversely to the longitudinal extent of the solid cylinder (V).
The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I)
applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
C09J 175/12 - Polyuréthanes à partir de composés contenant de l'azote et un hydrogène actif, l'atome d'azote ne faisant pas partie d'un groupe isocyanate
wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.
C08G 18/46 - Polycondensats contenant des groupes ester carboxylique ou carbonique dans la chaîne principale contenant des hétéro-atomes autres que l'oxygène
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
A61L 24/04 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires
C08G 63/91 - Polymères modifiés par post-traitement chimique
C08G 18/73 - Polyisocyanates ou polyisothiocyanates acycliques
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Adhesive for industrial purposes; adhesives for use in the
manufacture of surgical bandages. Pharmaceutical preparations for medical or veterinary
purposes, except dental cements; medical adhesives for
direct wound bonding; liquid tissue adhesive compositions
for medical purposes; liquid adhesive compositions for
postoperative adhesion barriers for medical purposes; wound
dressings, pharmaceutical preparations for wounds, dressings
for wound treatment; sponges for wound healing; medical
adhesives for wound closure; materials for dressing wounds;
antiseptic preparations for wound care; medical adhesives
for binding internal tissue; dressing materials, covering
materials and applicators [medical]; surgical adhesives;
adhesives for fixing prostheses; surgical plasters; surgical
and medical dressing materials. Medical and veterinary apparatus and instruments, except
containers for preparing serum; surgical seam and wound
closure materials and products; medical instruments and
apparatus for closing wounds; applicators for pharmaceutical
preparations; surgical wound closure apparatus and devices;
surgical and wound care equipment; surgical implants made
from synthetic materials; biodegradable implants.
The present invention relates to a polyurea system, the use of such a polyurea system for sealing, linking, gluing, or covering of cellular tissue, and a dosing system having two chambers for a polyurea system such as this. The polyurea system comprises as components: A) an isocyanate-functioning prepolymer, which can be derived by reacting aliphatic isocyanates with polyoles, and B) an amino-functioning ester of aspartic acid. According to the invention, water and/or tertiary amine is added to the system, in order to increase the reacting speed of the prepolymer with the amino-functioning ester of aspartic acid while decreasing the setting time at the same time.
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
A61L 24/04 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires
C08G 18/18 - Catalyseurs contenant des amines secondaires ou tertiaires ou leurs sels
C09J 175/12 - Polyuréthanes à partir de composés contenant de l'azote et un hydrogène actif, l'atome d'azote ne faisant pas partie d'un groupe isocyanate
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Adhesives for industrial purposes; adhesives for industrial
purposes for manufacturing for surgical dressings. Pharmaceutical products for medical or veterinary purposes;
medical adhesives for direct wound bonding; liquid tissue
adhesive compositions for medical use; liquid compositions
for postoperative adhesion barriers for medical use; wound
dressings; pharmaceutical wound preparations; dressings for
wound treatment; sponges for wound healing; medical
adhesives for wound closure; materials for dressing wounds;
antiseptic preparations for wound care; tissue adhesives;
dressing materials; covering materials and applicators
[medical]; surgical adhesives; adhesives for fixing
prostheses; surgical plasters; surgical and medical dressing
materials. Medical and veterinary apparatus and instruments; surgical
seam- and wound closure-materials and -products; medical
instruments for closing wounds; medical apparatus;
applicators for pharmaceutical preparations; surgical wound
closures; surgical and wound care equipment; medical
instruments for closing wounds; surgical seam- and
wound-closure-materials and -products; surgical implants
made from synthetic materials; biodegradable implants.
10.
Isocyanate-functional prepolymer for a biologically degradable fabric adhesive
b) a reaction of the preliminary stage bearing hydroxyl groups from step a) with a polyfunctional isocyanate to an isocyanate functional prepolymer.
The invention additionally relates to a process for producing this isocyanate functional prepolymer, a tissue adhesive system containing such an isocyanate functional prepolymer and a dispensing system having at least two chambers and this type of tissue adhesive system.
A61L 24/06 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons carbone-carbone non saturées
C08G 65/333 - Polymères modifiés par post-traitement chimique avec des composés organiques contenant de l'azote
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
C08G 18/73 - Polyisocyanates ou polyisothiocyanates acycliques
C08G 65/26 - Composés macromoléculaires obtenus par des réactions créant une liaison éther dans la chaîne principale de la macromolécule à partir d'éthers cycliques par ouverture d'un hétérocycle à partir d'éthers cycliques et d'autres composés
C08G 65/332 - Polymères modifiés par post-traitement chimique avec des composés organiques contenant de l'oxygène contenant des groupes carboxyle, ou leurs halogénures ou esters
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Adhesive for industrial purposes; adhesives for use in the manufacture of surgical bandages medical adhesives for direct wound bonding; liquid tissue adhesive compositions for medical purposes; liquid adhesive compositions for postoperative adhesion barriers for medical purposes; wound dressings, pharmaceutical preparations for wounds, dressings for wound treatment; medical adhesives for wound closure; materials for dressing wounds; antiseptic preparations for wound care; medical adhesives for binding internal tissue; surgical adhesives; adhesives for fixing prostheses; surgical plasters; surgical and medical dressing materials medical instruments and apparatus for closing wounds; surgical wound closure apparatus and devices; surgical implants made from synthetic materials
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical substances for medical or veterinary
purposes; medical adhesives for direct wound bonding; liquid
tissue adhesive compositions for medical purposes; liquid
tissue compositions for postoperative adhesion barriers for
medical purposes. Business management; business administration. Scientific and technological services and research and
design relating thereto; scientific and technological
services and research and design relating thereto relating
to substances for medical or veterinary purposes, for
medical adhesives for direct wound bonding, for liquid
tissue adhesive compositions for medical purposes and for
liquid compositions for postoperative adhesion barriers for
medical purposes.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Adhesives for industrial purposes. Substances for medical or veterinary purposes; adhesives for
direct wound bonding, tissue adhesives. Suture materials.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical products for medical or veterinary purposes;
medical adhesives for binding wounds; liquid tissue adhesive
compositions for medical use; liquid compositions for
postoperative adhesion barriers for medical use. Business management; business administration. Scientific and technological services and research and
design relating thereto; scientific and technological
services and research and design relating thereto concerning
products for medical or veterinary purposes, medical
adhesives for binding wounds, liquid tissue adhesive
compositions for medical use and liquid compositions for
postoperative adhesion barriers for medical use.
The present invention relates to a polyurea system, the use of such a polyurea system for sealing, linking, gluing, or covering of cellular tissue, and a dosing system having two chambers for a polyurea system such as this. The polyurea system comprises as components: A) an isocyanate-functioning prepolymer, which can be derived by reacting aliphatic isocyanates with polyoles, and B) an amino-functioning ester of aspartic acid. According to the invention, water and/or tertiary amine is added to the system, in order to increase the reacting speed of the prepolymer with the amino-functioning ester of aspartic acid while decreasing the setting time at the same time.
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.
C08G 18/46 - Polycondensats contenant des groupes ester carboxylique ou carbonique dans la chaîne principale contenant des hétéro-atomes autres que l'oxygène
C08G 63/91 - Polymères modifiés par post-traitement chimique
C08G 18/73 - Polyisocyanates ou polyisothiocyanates acycliques
A61L 24/04 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
C08G 18/38 - Composés de bas poids moléculaire contenant des hétéro-atomes autres que l'oxygène
C08G 18/42 - Polycondensats contenant des groupes ester carboxylique ou carbonique dans la chaîne principale
2 is an organic radical that does not contain Zerewitinoff-active hydrogen, a is 1 or 2, b is 1 or 2, and a+b=2 or 3, for stemming the escape of blood, and to a metering system for the polyurea system according to the invention.
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
C08G 18/12 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle utilisant plusieurs composés contenant un hydrogène actif dans le premier stade de la polymérisation
C08G 18/73 - Polyisocyanates ou polyisothiocyanates acycliques
A61L 24/04 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
19.
Tissue adhesive based on nitrogen-modified aspartates
The invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers which can be obtained by reacting aliphatic isocyanates A1) with polyols A2) that can have a number-average molecular weight of =400 g/mol and an average OH functionality of 2 to 6 in particular; and as component B) amino-functional aspartic acid esters of the general formula (I) in which X is an organic group containing a secondary amino function, R1, R2 are the same or different organic groups that do not have Zerewitinoff-active hydrogen, and n is a whole number of at least 2, in particular for sealing, bonding, gluing, or covering cell tissue. The invention also relates to a metering system for the polyurea system according to the invention.
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
A61L 24/04 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires
C08G 18/38 - Composés de bas poids moléculaire contenant des hétéro-atomes autres que l'oxygène
C08G 18/42 - Polycondensats contenant des groupes ester carboxylique ou carbonique dans la chaîne principale
C08G 18/73 - Polyisocyanates ou polyisothiocyanates acycliques
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
20.
Medical adhesives for stopping heavy bleeding and sealing leakages
The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I)
applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
C09J 175/12 - Polyuréthanes à partir de composés contenant de l'azote et un hydrogène actif, l'atome d'azote ne faisant pas partie d'un groupe isocyanate
