Abrégé

The present invention relates to an in vitro method for predicting the response of a bladder cancer patient to Bacillus Calmette-Guérin (BCG) immunotherapy, comprising determining the expression level or ratio of expression levels of miRNAs or combinations of miRNAs in a sample and comparing said expression level, or ratio of expression levels, to a reference value, wherein a difference in said comparison is indicative of said patient’s response to BCG therapy. The present invention also relates to kits for carrying out such methods and to uses of miRNAs, or combinations of miRNAs, to predict whether or not a bladder cancer patient will respond to BCG therapy.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

An anchor system for anchoring an umbilical catheter to an umbilical cord. The system has a vascular anchor element and an anchor clamp. The vascular anchor element has a duct configured to accommodate a portion of an umbilical catheter, and an end configured to be inserted into a blood vessel of the umbilical cord. The anchor clamp is configured to releasably retain at least one portion of the umbilical cord and at least one portion of the anchor element. The clamp has a slit configured to receive the at least one portion of the umbilical cord and the at least one portion of the anchor element; and a releasable locking system for selectively opening/closing the anchor clamp.

Classes IPC  ?

• A61M 25/02 - Dispositifs de maintien en position, p. ex. sur le corps
• A61M 25/00 - CathétersSondes creuses

Abrégé

A catheter applicator is disclosed which allows an aseptic and stable catheter insertion and handling. The applicator comprises, in particular, clamping members cooperating with a bearing surface for handling a catheter. A method of using the applicator is further provided.

Classes IPC  ?

• A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters

Abrégé

Disclosed is a method for determining the long-term evolution of acute brain damage in individuals, which comprises determining the expression product of at least two of the biomarkers SAA1, S100β and TLR4 in a biological sample taken from an individual, and establishing the statistical significance of the concentration of the expression product of the biomarker. Also disclosed is the use of a device for determining the expression product of the biomarkers, and a pharmaceutical composition for use in the treatment of acute brain damage.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The invention relates to a nicotinamide adenine dinucleotide (NAD+) precursor, or a pharmaceutical composition comprising same, for use in the prevention of the development of hereditary aortic aneurysms characterised by the presence of impaired mitochondrial respiration, and/or the treatment thereof. The invention also relates to a nutraceutical composition comprising a nicotinamide adenine dinucleotide (NAD+) precursor for use in preventing the development of hereditary aortic aneurysms characterised by the presence of impaired mitochondrial respiration.

Classes IPC  ?

• A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p. ex. adénosine, acide adénylique
• A61P 9/14 - VasoprotecteursAntihémorroïdauxMédicaments pour le traitement des varicesStabilisateurs capillaires

Abrégé

The invention relates to an anchor system for anchoring an umbilical catheter to an umbilical cord. The system comprises a vascular anchor element and an anchor clamp. The vascular anchor element comprises a duct configured to accommodate a portion of an umbilical catheter, and an end configured to be inserted into a blood vessel of the umbilical cord. The anchor clamp is configured to releasably retain at least one portion of the umbilical cord and at least one portion of the anchor element. The clamp comprises a slit configured to receive the at least one portion of the umbilical cord and the at least one portion of the anchor element; and a releasable locking system for selectively opening/closing the anchor clamp.

Classes IPC  ?

• A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical

Abrégé

The present invention relates to an in vitro method for predicting the response of a bladder cancer patient to Bacillus Calmette-Guérin (BCG) immunotherapy, which comprises determining the expression level or ratio of expression levels of miRNAs or combinations of miRNAs in a sample and comparing said expression level, or ratio of expression levels, to a reference value, wherein a difference in said comparison is indicative of said patient's response to BCG therapy. The present invention also relates to kits for carrying out such methods and to uses of miRNAs, or combinations of miRNAs, to predict whether or not a bladder cancer patient will respond to BCG therapy.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

The invention relates to an applicator for a catheter and to a method of use thereof, the applicator comprising: two parts for holding the catheter; two securing parts connected to the holding parts by means of force-transmitting arms; a support surface connected to the securing parts by second ends and forming an angle of 70-110° with the vertical; and a grip flap between the securing parts and the support surface. Also claimed is a method for using the applicator, which includes the steps of: opening the holding parts by applying a separating force to the flap; placing the catheter between the holding parts; securing the catheter by applying force to the securing parts; and, lastly, releasing the catheter by opening the holding parts.

Classes IPC  ?

• A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
• A61M 25/06 - Aiguilles avec un guide pour piquer le corps ou analogues

Abrégé

The present invention relates to stem cells from the placental decidua parietalis (DMSCs) for use in the treatment of chronic stress urinary incontinence in a subject. This invention also relates to a pharmaceutical composition comprising said DMSCs for the same use, and the kit and device comprising same.

Classes IPC  ?

• A61K 35/50 - PlacentaCellules souches placentairesLiquide amniotiqueAmniosCellules souches amniotiques
• C12N 5/0775 - Cellules souches mésenchymateusesCellules souches dérivées du tissu adipeux
• A61P 13/00 - Médicaments pour le traitement des troubles du système urinaire
• A61P 13/02 - Médicaments pour le traitement des troubles du système urinaire de l'urine ou des voies urinaires, p. ex. acidificateurs d'urine
• A61P 13/10 - Médicaments pour le traitement des troubles du système urinaire de la vessie

Abrégé

The present invention provides sustained release polymeric nanocapsules capable of releasing proteases such as collagenase with a controlled kinetic and a prolonged and sustainable effect over time(up to more than 10 days). Additionally, these nanocapsules protect the housed protease, preferably collagenase,against external aggressions maintaining its catalytic activity. In this way, this invention overcomes the currents problems associated with collagenase administration using a precise combination of monomers and cross-linkers, as described in the claims that allow the formation of degradable polymeric nanocapsules with collagenase embedded within. These capsules provide a sustained release of the housed enzyme thus providing a therapeutic improvement in comparison to current therapies thus decreasing the need for repeated injections or high collagenase doses.

Classes IPC  ?

• B01J 13/14 - Polymérisation, réticulation
• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
• A61K 9/51 - Nanocapsules

Abrégé

A prognostic method, and a kit, for determining the risk of relapse of renal cancer of the clear cell renal carcinoma type, stages I and II, in a human subject; comprised of: (a) determining, in a tumor sample (biopsy) from the human subject, the levels of expression of the microRNAs hsa-miR-223, hsa-miR-103, hsa-miR-107, hsa-miR-425, hsa-miR-340, hsa-miR-130b, hsa-miR-652, hsa-miR-214, and hsa-miR-204; (b) determining a value which depends on the levels of expression of the microRNAs; and (c) determining the risk of relapse in renal cancer of the clear cell renal carcinoma type, in stages I and II, in the said human subject, by comparing the value obtained in step (b) with a cut-off value.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• C12Q 1/6837 - Couplage enzymatique ou biochimique d’acides nucléiques à une phase solide utilisant des réseaux de sondes ou des puces à sondes
• G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne

Abrégé

A prognostic method and kit for identifying the risk of developing albuminuria, the risk of kidney damage and cardiovascular risk in a hypertensive human subject. The method comprises evaluating the concentration in urine of at least one compound selected from amongst glutamate, glycerate, guanidoacetate, pantothenate, oxalacetate, 3-ureidopropionate, 3-hydroxybutyrate, malate and pyruvate, determining whether at least one of the markers is above or below the standard values in healthy subjects, where said markers are the concentration of the compounds and panels comprising various compounds, and identifying the risks in said human subject.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/20 - Mesure des fonctions urologiques

Abrégé

The invention relates to a device for securing in an ostomy for the prevention of hernias, comprising an ostomy base (1) and a securing strap (12). The ostomy base is made of a rigid natural material and adopts a bridge shape, having a curved central section (2) provided with openings (5). The securing strap (12) is curved and provided with securing means (13) at the ends thereof.

Classes IPC  ?

• A61F 5/449 - Moyens d'assujettissement au corps, p. ex. ceintures, vêtements

Abrégé

A prognostic method, and a kit, for determining the risk of relapse of renal cancer of the clear cell renal carcinoma type, stages I and II, in a human subject; comprised of: (a) determining, in a tumor sample (biopsy) from the human subject, the levels of expression of the microRNAs hsa-miR-223, hsa-miR-103, hsa-miR-107, hsa-miR-425, hsa-miR- 340, hsa-miR-130b, hsa-miR-652, hsa-miR-214, and hsa-miR-204; (b) determining a value which depends on the levels of expression of the microRNAs; and (c) determining the risk of relapse in renal cancer of the clear cell renal carcinoma type, in stages I and II, in the said human subject, by comparing the value obtained in step (b) with a cut-off value.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The invention relates to an applicator device for catheters for the insertion of the catheter in a blood vessel, comprising a securing part (1) for being securely coupled to the base of a catheter, and a manual gripping part (3) suitable for being held by the fingers of a user. The securing part (1) and the manual gripping part (6) are joined to one another via a join that can be broken by means of manual action, such that, once the catheter has been inserted in a blood vessel, the manual gripping part (6) is removed. Due to the applicator, it is not necessary for the fingers of the health personnel to touch the proximal zone of the catheter (4), thereby minimising the risk of infection via phlebitis or bacteraemia that is secondary to the infection of the catheter. The invention also relates to a catheter including said applicator device.

Classes IPC  ?

• A61M 25/06 - Aiguilles avec un guide pour piquer le corps ou analogues

Abrégé

The invention relates to a mechanism including a laser signalling pointer (1) that can be linearly moved over the corresponding region of study of the breast of the patient, stopping at a point corresponding to previously determined coordinates (x,y), according to the exact point of the lesion to be located, such that once the lesion has been located in the plane, the mechanism or device will return to position (0Ό). Basically the mechanism comprises a base (2) with two linear guides (3) and a bridge (4) that can be moved on said guides and carries another guide and the laser signalling pointer (1), such that the movements can be carried out in any direction by means of two servomotors (16) and (17), controlled by a control unit (14) connected to a digital image viewing station (11) which will receive the exact co-ordinates by means of a computer application, using a screen (12) and the corresponding PC (13). The image showing the lesion is provided by a digital mammogram (6).

Classes IPC  ?

• A61B 6/12 - Agencements pour détecter ou localiser des corps étrangers
• A61B 18/20 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers
• A61B 17/34 - TrocartsAiguilles à ponction

Abrégé

The invention relates to a synthetic surgical mesh comprising a weave produced by means of filaments of a biologically compatible material, characterised in that it is formed by a monofilament or multifilament thread, woven so as to form a crocheted weave using a crochet technique, with a central core (4a) and a plurality of concentric rings (4, 4e) which define concentric openings (6) in a circular crown shape. Said rings (4c, 4, 4e) are joined together by means of portions of connecting thread (8), which increase in number the further the annular opening (6) over which they extend is from the centre. The invention is used to repair hernial defects in the front abdominal wall of a patient.

Classes IPC  ?

• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
• D04B 31/00 - Procédés de tricotage crochet utilisés pour la production des tricots ou articles
• A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents

Abrégé

The invention relates to a valve for preventing the waste of blood, formed from a valve body (6) consisting of a soft, flexible material split into two parts by means of an opening/closing valve (3) such that valve paths extend on both sides of said valve, one (4) for extracting the blood to be analysed and the other (5) for the blood to be reinjected. The body of the valve (6) also has an inlet with a connector to the catheter (1) and, on the opposite side, another connector to the serum and/or reinfusion system (2).

Classes IPC  ?

• A61M 39/02 - Voies d'accès

Abrégé

The invention relates to a method for selecting a therapy for the treatment of a patient with cutaneous T-cell lymphoma (LCCT), said method comprising determining the presence of a mutation in the PLCG1 gene in a sample from said patient, and selecting the therapy according to the mutational profile of the patient.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The invention relates to an animal model with cognitive deficit, exhibiting absence of megalin specifically in the endothelium of the brain capillaries. The invention also relates to the method for obtaining same and to the use thereof as a model of neurodegenerative diseases, more concretely, in Alzheimer disease.

Classes IPC  ?

• A01K 67/027 - Nouvelles races ou races modifiées de vertébrés
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• C07K 14/05 - Virus Epstein-Barr

Abrégé

The invention relates to methods based on the quantification of a set of biomarkers, preferably in biological samples isolated from skeletal muscle, for performing the diagnosis, prognosis and/or monitoring of muscular degeneration, preferably muscular degeneration caused by motor neuron diseases, more preferably amyotrophic lateral sclerosis (ALS); and to a kit for the diagnosis, prognosis and monitoring of said type of diseases. The method in the invention for the prognosis and/or monitoring of muscular degeneration makes it possible to determine the rate of progression of said degeneration (fast or slow rate of progression in relation to the normal rate of progression).

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques