The present invention relates to an injectable composite depot, which is shear-thinning. The composite depot comprises up to 85 weight-% of silica microparticles having a maximum diameter of ≤1000 μm, and preferably at least one encapsulated biologically active agent. The microparticles are combined with a silica sol having a silica content of ≤5 weight-%, preferably ≤2 weight-%, more preferably ≤1 weight-%. The injectable composite depot further comprises at least one pharmaceutically non-active additive encapsulated in the silica microparticles and/or present in the silica sol.
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
2.
SILICA HYDROGEL COMPOSITE WITH A WATER SOLUBLE ADDITIVE
The present invention relates to a silica hydrogel composite, which is shear-thinning. The silica hydrogel composite comprises up to 85 weight-% of silica microparticles having a maximum diameter of ≤ 1 000 µm, combined with a silica sol which has a solid content of ≤5 weight-%. According to the invention, at least one water soluble additive having a solubility in water of at least 3 mg/ml, at pH 7, at 25 °C, is encapsulated in at least some of the silica microparticles.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
The invention relates to a silica hydrogel composite, which is shear thinning. The silica hydrogel composite comprises a) up to 85 weight-% of silica particles having a maximum diameter of ≤1000 µm, and b) a silica sol having a silica content of ≤5 weight-%. According to the invention the silica particles comprise an encapsulated agent selected from a GLP-1 receptor agonist, a dual GIP/GLP-1 receptor agonist, or a triple GIP/GLP-1/GCG receptor agonist.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry; Biological preparations for use in industry and science; Proteins for use in manufacture; Cell culture media for laboratory use; Cell culture reagents for laboratory use; Cell culture media for scientific or research purposes; Cell culture reagents for scientific or research purposes; Chemicals for use in biotechnological manufacturing processes; Culture media for microbiology; Media for cell culture for use in the biotechnological industry; Chemical compositions and materials for use in science; Silicates; Adjuvants, other than for medical or veterinary purposes. Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for human beings and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Preparations for destroying vermin; Fungicides, herbicides; Biological preparations for diagnostic purposes; Biological preparations for medical purposes; Biological reagents for medical use; Biological reagents for veterinary use; Biological preparations for use in cell cultures (medical); Biotechnological preparations for medical use; Pharmaceutical preparations for activating cellular function; Regulatory proteins for medical use; Biological adjuvants for medical purposes; Vaccine preparations; Vaccine adjuvants; Injectable pharmaceuticals; Injectable dermal fillers; Drug delivery agents; Drug delivery agents that facilitate the delivery of pharmaceutical preparations; Agents for controlled release of pharmaceutical preparations; Antibacterial gels; Anti-inflammatory gels; Medicated body gels; Topical first aid gels; Topical gels for medical and therapeutic use; Medicated oral care gels; Gels for dermatological use; Massage gels for medical purposes; Body gels for pharmaceutical use; Pharmaceutical implants; Implantable medicines; Medicated plasters; Chemical preparations for pharmaceutical purposes; Liniments; Ointments for pharmaceutical purposes; Therapeutic creams [medical]; Medicinal oils, other than essential oils; Adhesive bands for medical purposes; Cooling sprays for medical purposes; Medicated wipes; Micro- and nanoparticles, in the form of gel, for the local administration of therapeutic agents and preparations; Diagnostic preparations for medical purposes; Diagnostic preparations for veterinary purposes; Medical, pharmaceutical and veterinary preparations for parenteral, oral, intravenous, intramuscular and subcutaneous administration; Adjuvants for medical purposes; Medicinal infusions; Medicines for human purposes; Medicines for veterinary purposes; Vaccines; Viral vaccines; Vaccines for human use; Veterinary vaccines. Automatic dosage apparatus; Activation equipment and injection systems of micro- and nanoparticles for the local administration of therapeutic agents, not for medical purposes. Surgical, medical, dental and veterinary apparatus and instruments, none of the aforementioned goods for examining eyes and/or testing of vision; Orthopedic articles; Suture materials; Apparatus for drug administration; Implantable subcutaneous drug delivery devices; Infusion and injection devices for pharmaceuticals; Medical activation equipment and injection systems of micro- and nanoparticles for the local administration of therapeutic agents; Hypodermic injectors; Autoinjectors for the administration of pharmaceutical preparations; Dosage dispensers for medical use; Injectors for medical purposes; Syringes for injections. Scientific and technological services and research and design relating thereto; Industrial analysis, industrial research and industrial design services; Quality control and authentication services; Biotechnological research; Consultancy in the field of biotechnology; Research and development in the field of biotechnology; Pharmaceutical research and development; Development of pharmaceutical preparations and medicines; Clinical trials; Medical research; Scientific laboratory services; Analytical laboratory services; Research and development of vaccines and medicines; Scientific research in the field of controlled release of pharmaceutical preparations; Scientific research in the field of micro- and nanoparticles and methods for drug delivery; none of the abovementioned services are in the field of virtual modelling and simulation in relation to prostheses, implants and biomechanical analysis systems. Medical services; Veterinary services; Hygienic and beauty care for human beings or animals; Consultancy and information services relating to medical products; Pharmaceutical services; Dispensing of pharmaceuticals; Consultancy and information services relating to pharmaceutical products; Vaccination services.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry; Biological preparations for use in industry and science; Proteins for use in manufacture; Cell culture media for laboratory use; Cell culture reagents for laboratory use; Cell culture media for scientific or research purposes; Cell culture reagents for scientific or research purposes; Chemicals for use in biotechnological manufacturing processes; Culture media for microbiology; Media for cell culture for use in the biotechnological industry; Chemical compositions and materials for use in science; Silicates; Adjuvants, other than for medical or veterinary purposes. Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for human beings and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Preparations for destroying vermin; Fungicides, herbicides; Biological preparations for diagnostic purposes; Biological preparations for medical purposes; Biological reagents for medical use; Biological reagents for veterinary use; Biological preparations for use in cell cultures (medical); Biotechnological preparations for medical use; Pharmaceutical preparations for activating cellular function; Regulatory proteins for medical use; Biological adjuvants for medical purposes; Vaccine preparations; Vaccine adjuvants; Injectable pharmaceuticals; Injectable dermal fillers; Drug delivery agents; Drug delivery agents that facilitate the delivery of pharmaceutical preparations; Agents for controlled release of pharmaceutical preparations; Antibacterial gels; Anti-inflammatory gels; Medicated body gels; Topical first aid gels; Topical gels for medical and therapeutic use; Medicated oral care gels; Gels for dermatological use; Massage gels for medical purposes; Body gels for pharmaceutical use; Pharmaceutical implants; Implantable medicines; Medicated plasters; Chemical preparations for pharmaceutical purposes; Liniments; Ointments for pharmaceutical purposes; Therapeutic creams [medical]; Medicinal oils, other than essential oils; Adhesive bands for medical purposes; Cooling sprays for medical purposes; Medicated wipes; Micro- and nanoparticles, in the form of gel, for the local administration of therapeutic agents and preparations; Diagnostic preparations for medical purposes; Diagnostic preparations for veterinary purposes; Medical, pharmaceutical and veterinary preparations for parenteral, oral, intravenous, intramuscular and subcutaneous administration; Adjuvants for medical purposes; Medicinal infusions; Medicines for human purposes; Medicines for veterinary purposes; Vaccines; Viral vaccines; Vaccines for human use; Veterinary vaccines. Automatic dosage apparatus; Software as a medical device [SaMD], downloadable; Computer software relating to the medical field; Activation equipment and injection systems of micro- and nanoparticles for the local administration of therapeutic agents, not for medical purposes. Surgical, medical, dental and veterinary apparatus and instruments; Orthopedic articles; Suture materials; Apparatus for drug administration; Implantable subcutaneous drug delivery devices; Infusion and injection devices for pharmaceuticals; Medical activation equipment and injection systems of micro- and nanoparticles for the local administration of therapeutic agents; Hypodermic injectors; Autoinjectors for the administration of pharmaceutical preparations; Diagnostic apparatus for medical purposes; Dosage dispensers for medical use; Injectors for medical purposes; Syringes for injections. Scientific and technological services and research and design relating thereto; Industrial analysis, industrial research and industrial design services; Quality control and authentication services; Biotechnological research; Consultancy in the field of biotechnology; Research and development in the field of biotechnology; Pharmaceutical research and development; Development of pharmaceutical preparations and medicines; Clinical trials; Medical research; Scientific laboratory services; Analytical laboratory services; Research and development of vaccines and medicines; Scientific research in the field of controlled release of pharmaceutical preparations; Scientific research in the field of micro- and nanoparticles and methods for drug delivery. Medical services; Veterinary services; Hygienic and beauty care for human beings or animals; Consultancy and information services relating to medical products; Pharmaceutical services; Dispensing of pharmaceuticals; Consultancy and information services relating to pharmaceutical products; Vaccination services.
The present invention relates to an injectable composite depot, which is shear- thinning. The composite depot comprises up to 85 weight-% of silica microparticles having a maximum diameter of ≤1 000 µm, and preferably at least one encapsulated biologically active agent. The microparticles are combined with a silica sol having a silica content of ≤5 weight-%, preferably ≤2 weight-%, more preferably ≤1 weight- %. The injectable composite depot further comprises at least one pharmaceutically non-active additive encapsulated in the silica microparticles and/or present in the silica sol.
The present invention relates to a silica hydrogel composite comprising non-active silica particles and solid particles of active pharmaceutical ingredient or ingredients. The silica hydrogel composite is feasible for controlled and sustained delivery of active pharmaceutical ingredients.
The present invention relates to a silica hydrogel composite comprising non-active silica particles and solid particles of active pharmaceutical ingredient or ingredients. The silica hydrogel composite is feasible for controlled and sustained delivery of active pharmaceutical ingredients.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry; Unprocessed artificial resins, unprocessed plastics; Fire extinguishing and fire prevention compositions; Tempering and soldering preparations; Substances for tanning animal skins and hides; Adhesives for use in industry; Putties and other paste fillers; Compost, manures, fertilizers; Biological preparations for use in industry and science; Biological tissue cultures, other than for medical or veterinary purposes; Proteins for use in manufacture; Biological preparations, other than for medical or veterinary purposes; Reagents for use in scientific apparatus for chemical or biological analysis; Cell culture media for laboratory use; Cell culture reagents for laboratory use; Cell culture media for scientific or research purposes; Cell culture reagents for scientific or research purposes; Chemicals for use in biotechnological manufacturing processes; Culture media for microbiology; Cultures, other than for medical or veterinary use; Cultures of cell media [other than for medical or veterinary use]; Cultures of microorganisms, other than for medical and veterinary use; Media for cell culture for use in the biotechnological industry; Protein [raw material]; Silicon carbide [raw material]; Unprocessed artificial resins as raw materials in the form of powders, liquids or pastes. Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for human beings and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides; Biological preparations for diagnostic purposes; Biological preparations for medical purposes; Biological reagents for medical use; Biological reagents for veterinary use; Biological preparations for use in cell cultures (medical); Biotechnological preparations for medical use; Pharmaceutical preparations for activating cellular function; Regulatory proteins for medical use; Biological adjuvants for medical purposes; Vaccine preparations; Vaccine adjuvants; Veterinary vaccines. Surgical, medical, dental and veterinary apparatus and instruments; Artificial limbs, eyes and teeth; Orthopaedic articles; Suture materials; Therapeutic and assistive devices adapted for persons with disabilities; Massage apparatus; Apparatus, devices and articles for nursing infants; Sexual activity apparatus, devices and articles; Apparatus for drug administration; Implantable subcutaneous drug delivery devices. Scientific and technological services and research and design relating thereto; Industrial analysis, industrial research and industrial design services; Quality control and authentication services; Design and development of computer hardware and software; Biotechnological research; Consultancy in the field of biotechnology; Research and development in the field of biotechnology; Pharmaceutical research and development; Development of pharmaceutical preparations and medicines; Clinical trials; Medical research; Scientific laboratory services; Analytical laboratory services; Research and development of vaccines and medicines.
This invention relates to a depot formulation comprising a biodegradable silica hydrogel composite incorporating a nucleotide or nucleoside analog reverse transcriptase inhibitor, wherein the silica hydrogel composite is obtainable by mixing silica particles comprising said nucleotide or nucleoside analog reverse transcriptase inhibitor and having a maximum diameter of ≤1 000 μm, as such or as a suspension, with silica sol wherein the hydrogel composite is non-flowing and structurally stable when stored at rest and shear-thinning when shear stress is applied by injection. The present invention also relates to use of the depot formulation for treatment of chronic viral infections and prevention of chronic viral reinfection. The present invention further relates to a prefilled syringes comprising said depot formulation.
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
A61K 31/522 - Purines, p. ex. adénine ayant des groupes oxo liés directement à l'hétérocycle, p. ex. hypoxanthine, guanine, acyclovir
This invention relates to a depot formulation comprising a biodegradable silica hydrogel composite incorporating a nucleotide or nucleoside analogue reverse transcriptase inhibitor, wherein the silica hydrogel composite is obtainable by mixing silica particles comprising said nucleotide or nucleoside analogue reverse transcriptase inhibitor and having a maximum diameter of ≤ 1 000 μm, as such or as a suspension, with silica sol wherein the hydrogel composite is non-flowing and structurally stable when stored at rest and shear-thinning when shear stress is applied by injection. The present invention also relates to use of the depot formulation for treatment of chronic viral infections and prevention of chronic viral reinfection. The present invention further relates to a prefilled syringes comprising said depot formulation.
This invention relates to a depot formulation comprising a biodegradable silica hydrogel composite incorporating a nucleotide or nucleoside analogue reverse transcriptase inhibitor, wherein the silica hydrogel composite is obtainable by mixing silica particles comprising said nucleotide or nucleoside analogue reverse transcriptase inhibitor and having a maximum diameter of = 1 000 µm, as such or as a suspension, with silica sol wherein the hydrogel composite is non-flowing and structurally stable when stored at rest and shear-thinning when shear stress is applied by injection. The present invention also relates to use of the depot formulation for treatment of chronic viral infections and prevention of chronic viral reinfection. The present invention further relates to a prefilled syringes comprising said depot formulation.
This invention relates to a silica hydrogel composite obtainable by mixing silica particles, comprising an encapsulated agent, with a silica sol, wherein obtained hydrogel composite is shear-thinning. The present invention also relates to use of the silica hydrogel composite according to the invention for an injectable, flowing or extrudable formulation. The present invention further relates to a method for preparing the silica hydrogel.
This invention relates to a silica hydrogel composite obtainable by mixing silica particles, comprising an encapsulated agent, with a silica sol, wherein obtained hydrogel composite is shear-thinning. The present invention also relates to use of the silica hydrogel composite according to the invention for an injectable, flowing or extrudable formulation. The present invention further relates to a method for preparing the silica hydrogel.
This invention relates to a silica hydrogel composite obtainable by mixing silica particles, comprising an encapsulated agent, with a silica sol, wherein obtained hydrogel composite is shear-thinning. The present invention also relates to use of the silica hydrogel composite according to the invention for an injectable, flowing or extrudable formulation. The present invention further relates to a method for preparing the silica hydrogel.
A method for storing a water-soluble undissolved silica-based material, optionally with an incorporated functional agent. The method includes immersing the material in an aqueous liquid phase which is initially saturated with a water-soluble silica-based material which is the same or different than the undissolved silica-based material, such that the undissolved silica-based material does not essentially dissolve into the liquid phase during storage, or the proportion of the amount of the initially undissolved silica-based material to the amount of the liquid phase is such that the liquid phase will be saturated or essentially saturated by a dissolved portion of the water-soluble undissolved silica-based material during storage, which dissolved portion of said water soluble undissolved silica-based material is less than 20%. Also disclosed is a storage package which may preferably be used to store functional agents, delivery devices or implants.
The present invention relates to a method for producing a flowing silica composition comprising a sol-gel transfer, wherein redispersion is carried out. The redispersion comprises adding, after having reached gel point of said sol-gel transfer, liquid into the gel formed by the sol-gel transfer, and the adding being made within a sufficiently short time period after reaching the gel point, to result, after mixing to follow of the gel and the liquid, in a rheologically homogenous flowing silica composition, which is and remains injectable as such, or by short stirring < 30 s, through a thin 22G needle. The present invention also relates to flowing silica compositions and gels obtainable by methods of the invention. The present invention further relates to uses of flowing silica compositions.
The present invention relates to a method for producing a flowing silica composition comprising a sol-gel transfer, wherein redispersion is carried out. The redispersion comprises adding, after having reached gel point of said sol-gel transfer, liquid into the gel formed by the sol-gel transfer, and the adding being made within a sufficiently short time period after reaching the gel point, to result, after mixing to follow of the gel and the liquid, in a rheologically homogenous flowing silica composition, which is and remains injectable as such, or by short stirring ឬ 30 s, through a thin 22G needle. The present invention also relates to flowing silica compositions and gels obtainable by methods of the invention. The present invention further relates to uses of flowing silica compositions.
2 is prepared from a sol comprising water, an alkoxide or inorganic silicate and a lower alcohol using a mineral acid or a base as a catalyst and the sol is aged and dried. The method uses a pH from 1.5 to 2.5, a molar ratio of water to the alkoxide or inorganic silicate of 0.5 to 2.5, a molar ratio of alcohol to the alkoxide or inorganic silicate is ≥0.5; and the sol is either let to gel without induced changes of composition and without forced drying of the sol, or a change of composition is induced; and within a time of ≤30 minutes, from the induced change forced drying of the sol is carried out or initiated.
C03B 19/12 - Autres méthodes de façonnage du verre par des procédés à réaction en phase liquide
C03C 4/00 - Compositions pour verres ayant des propriétés particulières
C04B 35/14 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base de silice
C04B 35/626 - Préparation ou traitement des poudres individuellement ou par fournées
C04B 35/63 - Préparation ou traitement des poudres individuellement ou par fournées utilisant des additifs spécialement adaptés à la formation des produits
