05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Produits d'origine chimique ou biologique destinés à des analyses, réactions, dosages, mesures et contrôles pour la médecine humaine et vétérinaire, nommément préparations réactives pour le diagnostic médical.
(2) Appareils permettant la réalisation automatique de dosages biologiques dans le domaine de l'analyse médicale pour la médecine humaine et vétérinaire nommément appareils électroniques permettant la numération et la différenciation des cellules sanguines, la réalisation de frottis sanguins, automates d'analyse (appareils) d'hématologie cellulaire et automates d'analyse (appareils) d'hématologie de paillasse pour la réalisation automatique de tests sanguins.
2.
DEVICE FOR HOLDING AND LIMITING THE ROTATION OF A BLOOD-COLLECTION TUBE OR OF A CYLINDRICAL CONTAINER FITTED IN A CAVITY
An elastic-ring device for holding biological containers in position for the automatic reading of identification codes or of information printed directly on the containers or on labels applied to the containers, and more particularly to automated identification of blood-collection sample tubes and additionally other types of biological-product containers passing through the automated system.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Biological chemical products used for analyses, reactions, assays, testing in laboratories, for human and veterinary medicine, namely, chemical prothrombin time reagents for assaying the factors of the endogenous pathway of blood coagulation, for medical and veterinary medicine
4.
METHOD FOR ANALYZING DEPENDENT HEPARIN PLATELET ACTIVATION
CENTRE HOSPITALIER RÉGIONAL UNIVERSITAIRE DE TOURS (France)
Inventeur(s)
Gruel, Yves, Jean, Hubert
Rollin, Jérôme
Charuel, Noémie, Aurélie, Ludivine
Pouplard, Claire
Abrégé
in vitroin vitro diagnosis of a heparin-induced thrombocytopenia or a diagnosis of exclusion of heparin-induced thrombocytopenia in a patient, comprising specific steps.
C12Q 1/56 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des facteurs de coagulation du sang, p. ex. faisant intervenir la thrombine, la thromboplastine, le fibrinogène
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
5.
Automatic device for the automated conduct of analyses, notably medical analyses
47. a bottle conveyor and storage system, configured selectively and individually to transport a bottle from a location in the storage zone to the unloading zone or from the loading zone to a location in the storage zone.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01L 3/00 - Mesure du couple, du travail, de la puissance ou du rendement mécanique en général
B01L 9/06 - Supports de tubes à essaiPorte-tubes à essai
B60P 1/00 - Véhicules destinés principalement au transport des charges et modifiés pour faciliter le chargement, la fixation de la charge ou son déchargement
B65G 47/26 - Dispositifs pour influencer la position relative ou l'orientation des objets pendant le transport par transporteurs arrangeant les objets, p. ex. faisant varier l'espace entre chaque objet
B65G 54/02 - Transporteurs non mécaniques, non prévus ailleurs électrostatiques, électriques ou magnétiques
G01N 1/14 - Dispositifs d'aspiration, p. ex. pompesDispositifs d'éjection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G06F 17/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des fonctions spécifiques
G07F 11/00 - Appareils déclenchés par des pièces de monnaie pour distribuer ou délivrer d'une façon analogue, des articles d'une façon discontinue
H05B 1/00 - Détails des dispositifs de chauffage électrique
6.
IN VITRO MEASUREMENT OF THE LYSIS OF A FIBRIN CLOT
The invention relates to a method for the in vitro measurement of the fibrin clot degradation on the basis of a curve of lysis of a fibrin clot over time in a blood or plasma sample previously obtained from a patient who may have a deficiency in at least one coagulation factor, said method including determining a basal level value for the fibrin clot at a time t1, and determining a degraded level value for the fibrin clot at a subsequent time t2. The method may comprise an additional step of classifying the tested sample in a group reflecting a lysis profile of a fibrin clot. The invention also relates to a method for monitoring a therapeutic treatment administered to a patient who may have or who has a deficiency in at least one coagulation factor, which method may likewise comprise, in addition, a step of adjusting the therapeutic treatment followed by said patient, depending on the classification obtained. The invention further relates to the use of an anti-fibrinolytic, in particular tranexamic acid (TXA) or a composition comprising same, for use thereof in a therapeutic treatment, said use comprising carrying out a method according to the invention, and means for implementing the invention.
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
C12Q 1/56 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des facteurs de coagulation du sang, p. ex. faisant intervenir la thrombine, la thromboplastine, le fibrinogène
Diagnostic instruments for use in hospital or private medical analysis laboratories, namely, semi-automated testing devices for measuring blood coagulation
8.
Universal Calibration Method for Assaying Enzymatic Inhibitors
The present invention relates to a universal calibration method of use for assaying inhibitors of the same enzyme, for example for assaying inhibitors of an enzyme of blood coagulation. The invention also relates to the use of this universal calibration in a method for assaying a reversible or irreversible inhibitor of the enzyme in a biological sample. The invention also relates to the use of the universal calibration in a method for screening inhibitors of the enzyme.
C12Q 1/56 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des facteurs de coagulation du sang, p. ex. faisant intervenir la thrombine, la thromboplastine, le fibrinogène
G16B 20/00 - TIC spécialement adaptées à la génomique ou protéomique fonctionnelle, p. ex. corrélations génotype-phénotype
The invention relates to an elastic-ring device for holding biological containers in position for the automatic reading of identification codes or of information printed directly on the containers or on labels applied to the containers. It applies more particularly to the automated identification of blood-collection sample tubes and additionally other types of biological-product containers passing through the automated system.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer software and hardware for laboratory information
management; computer hardware and software for monitoring
medical diagnostic instruments; computer hardware and
software for monitoring laboratory diagnostic instruments. Apparatus for automatically conducting assays and biological
measurements in the field of medical analysis for human and
veterinary medicine. Analysis of information accessible on a software platform
and relating to diagnostic and laboratory equipment in the
field of medical diagnostics.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
35 - Publicité; Affaires commerciales
37 - Services de construction; extraction minière; installation et réparation
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Diagnostic preparations for medical use, diagnostic
preparations for veterinary use, chemical reagents for
medical or veterinary use, diagnostic biomarker reagents for
medical use, chemical preparations for medical use, chemical
preparations for pharmaceutical use, biological preparations
for medical use, chemical pharmaceutical preparations,
biological preparations for veterinary use, chemical
preparations for veterinary use, serum, colorants for in
vitro diagnostics for medical use. Downloadable computer software applications,
intercommunication apparatus, software (recorded programs),
computer hardware, monitors (computer programs), computer
platforms in the nature of recorded or downloadable
software, processors (central processing units), central
processing units (processors), downloadable computer
programs, recorded computer operating system programs,
readers (data processing equipment). Diagnostic apparatus for medical use, testing apparatus for
medical use, blood testing apparatus, medical apparatus and
instruments, veterinary apparatus and instruments. Administrative services for medical referrals, compiling
information into computer databases, registration of written
data and communications, computerized file management
services, updating and maintenance of data in computer
databases, business inquiries, compilation of statistics,
administrative processing of purchase orders, wholesale
services for pharmaceutical, veterinary and sanitary
preparations as well as medical supplies, data searching in
computer files for others. Installation, servicing and repair of machines,
installation, servicing and repair of computer hardware,
installation and repair of electrical appliances, providing
information with respect to repair. Providing access to databases, providing user access to
global computer networks, providing Internet chatrooms,
transmitting digital files, telecommunications routing and
junction services, electronic bulletin board services
(telecommunications) transmitting data by streaming,
transmitting messages, computer-assisted transmission of
messages and images. Technological advisory services, quality control, developing
computer platforms, scientific laboratory services,
maintenance of computer software, biological research,
medical research, computer system analysis, software as a
service (SaaS), updating of software.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Logiciels et matériels informatiques pour la gestion et la surveillance des données de mesures obtenues à partir d'équipements de laboratoires nommément automates d'analyse pour mesurer la numération et différentiation des cellules sanguines.
(2) Appareils permettant la réalisation automatique de dosages et de mesures biologiques dans le domaine de l'analyse médicale pour la médecine humaine et vétérinaire. (1) Plateforme en tant que services (PaaS) comprenant un logiciel pour la collecte, la gestion et l'analyse de données de mesures obtenues à partir d'équipements de laboratoires nommément automates d'analyse pour mesurer la numération et différentiation des cellules sanguines.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Recorded and downloadable computer software and hardware for laboratory information management; computer hardware and recorded and downloadable software for monitoring medical diagnostic instruments; computer hardware and recorded and downloadable software for monitoring laboratory diagnostic instruments Apparatus for automatically conducting assays and biological measurements in the field of medical analysis for human and veterinary medicine, namely blood cell testing apparatus Analysis of information being medical data accessible on a software platform and relating to diagnostic and laboratory equipment in the field of medical diagnostics
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
computer software for use in laboratory information management and Laboratory information management equipment; computer software and hardware for monitoring medical diagnostic instruments; computer software and hardware for monitoring laboratory diagnostic instruments. Apparatus for automatic biological measurement and dosage in the field of medical analysis for human and veterinary medicine. Data management services accessible via a computer software platform relating to laboratory and diagnostic equipment in the field of medical diagnostics. Scientific information analysis services accessible via a computer software platform relating to laboratory and diagnostic equipment in the field of medical diagnostics.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
35 - Publicité; Affaires commerciales
37 - Services de construction; extraction minière; installation et réparation
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Préparations réactives pour le diagnostic médical ; préparations réactives pour le diagnostic vétérinaire ; réactifs de biomarquage pour le diagnostic à usage médical.
(2) Applications logiciels informatiques téléchargeables nommément logiciel téléchargeable permettant d'interpréter, d'afficher, de gérer et d'échanger des informations concernant les soins de santé, nommément les résultats d'essais provenant de dispositifs de diagnostic in vitro ; matériel informatique ; matériel informatique et logiciel téléchargeable pour la réception, le traitement, la transmission et l'affichage de données provenant de dispositifs d'essais médicaux, à savoir des dispositifs de diagnostic in vitro ; processeurs (unités centrales de traitement) ; unités centrales de traitement (processeurs) ; programmes du système d'exploitation enregistrés pour ordinateurs.
(3) Appareils permettant la réalisation automatique des dosages biologiques dans le domaine de l'analyse médicale, nommément machines électroniques permettant de déterminer les dosages de l'hémostase et des facteurs de thrombose et de coagulation, machines électroniques permettant de déterminer la numération et différentiation des cellules sanguines, automates d'analyse pour mesurer la coagulation sanguine, automates d'analyse pour mesurer la numération et différentiation des cellules sanguines, automates de paillasse pour la réalisation automatique de tests sanguins chronométriques, colorimétriques et immuno-turbidimétriques et automates de paillasse pour la numération et différentiation des cellules sanguines ; instruments vétérinaires. (1) Services administratifs pour recommandations médicales ; services de gestion informatisée de fichiers ; mise à jour et maintenance de données dans des bases de données informatiques ; établissement de statistiques ; traitement administratif de commandes d'achats ; services de vente en gros de préparations pharmaceutiques, vétérinaires et hygiéniques ainsi que de fournitures médicales ; renseignements d'affaires nommément conseils en organisation des laboratoires d'analyses médicales ; compilation de données statistiques à usage de recherches scientifiques ou médicales.
(2) Installation, entretien et réparation de machines nommément de dispositifs de diagnostic in vitro ; entretien et réparation de matériel informatique ; mise à disposition d'informations en matière de réparation de dispositifs de diagnostic in vitro.
(3) Fourniture d'accès à des bases de données ; fourniture d'accès utilisateur à des réseaux informatiques mondiaux ; mise à disposition de forums de discussion sur l'internet.
(4) Service de contrôle de la qualité de laboratoire médical ; services de conseils aux laboratoires médicaux pour obtenir leur conformité aux normes de certification ; services de laboratoire médical ; maintenance de logiciels d'ordinateurs ; recherches biologiques, recherches médicales ; mise à jour de logiciels ; logiciel service (saas) fourni pour accéder à des renseignements médicaux et à des renseignements sur la santé ; logiciel-service (saas) fourni pour le diagnostic, la surveillance et le traitement de renseignements médicaux et de renseignements sur la santé.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
35 - Publicité; Affaires commerciales
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Providing access to databases; providing user access to global computer networks; providing Internet chatrooms; transmitting digital files; telecommunications routing and junction services; electronic bulletin board services being telecommunications services; transmitting data by streaming; electronic message transmission; computer-assisted transmission of messages and images Diagnostic preparations for medical use; diagnostic preparations for veterinary use; chemical reagents for medical or veterinary use; diagnostic biomarker reagents for medical use; chemical preparations for medical uses, namely, for blood disorders; chemical preparations for pharmaceutical uses namely, for blood disorders; biological preparations for medical use namely, for blood disorders; chemical pharmaceutical preparations namely, for blood disorders; biological preparations for veterinary use namely, for blood disorders; chemical preparations for veterinary use namely, for blood disorders; colorants for in vitro diagnostic reagents for medical use Downloadable computer software applications for blood testing in the field of in-vitro diagnostics for medical and veterinary use; intercommunication apparatus, namely transmitters and receivers for use with blood testing apparatus and computers; recorded software for blood testing in the field of in-vitro diagnostics for medical and veterinary use; computer hardware; monitors being downloadable and recorded computer programs blood testing in the field of in-vitro diagnostics for medical and veterinary use; computer platforms in the nature of recorded and downloadable software for blood testing in the field of in-vitro diagnostics for medical and veterinary use; central processing units; downloadable computer programs for blood testing in the field of in-vitro diagnostics for medical and veterinary use ; recorded computer operating system programs Diagnostic apparatus for medical use, namely, in-vitro blood testing apparatus; testing apparatus for medical use, namely, in-vitro blood testing apparatus; blood testing apparatus; veterinary apparatus and instruments, namely, in-vitro blood testing apparatus Business administrative services for medical referrals; compiling information into computer databases; registration of written data and communications in the field of medical and veterinary in-vitro diagnostics; computerized file management services; updating and maintenance of data in computer databases; business inquiries; compilation of statistics; administrative processing of purchase orders; wholesale store services featuring pharmaceutical, veterinary and sanitary preparations as well as medical supplies; data searching in computer files for others Installation, servicing and repair of machines; installation, servicing and repair of computer hardware; installation and repair of electrical appliances; providing information with respect to repair of machines, computer hardware and electrical appliances in the field of medical and veterinary in-vitro diagnostics apparatus and instruments Technological advisory services in the field of medical and veterinary in-vitro diagnostics; quality control; developing computer platforms; scientific laboratory services; maintenance of computer software; biological research; medical research; computer system analysis; software as a service (SaaS) services featuring software for blood testing in the field of medical or veterinary in-vitro diagnostics; updating of software
18.
METHOD FOR DETECTING THE PRESENCE, IDENTIFICATION AND QUANTIFICATION IN A BLOOD SAMPLE OF ANTICOAGULANTS WHICH ARE BLOOD COAGULATION ENZYMES INHIBITORS, AND MEANS FOR THE IMPLEMENTATION THEREOF
Disclosed is an in vitro method for detecting, in a biological sample, the presence of a blood coagulation enzyme inhibitor selected, independently, from factor Xa and factor IIa, the method including the step of making one or more competitive kinetics measurement(s) by carrying out a competitive enzymatic assay and implementing one or more types of classification or regression decision models obtained by training automated supervised learning models. The method may include the identification in the biological sample of an inhibitor in question, or even its characterization, or even its quantification. Also disclosed is a data processing system or device including implementation for at least part of the method, a computer program or storage medium which can be read by a computer or appropriate data, and a suitable kit.
C12Q 1/56 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des facteurs de coagulation du sang, p. ex. faisant intervenir la thrombine, la thromboplastine, le fibrinogène
The analysis method includes a step of measuring cytometry parameters for each biological cell contained in a biological sample; a step of determining, for each biological cell of the biological sample, a point in a N-dimensional space whose coordinates are defined depending on the cytometry parameters measured for the corresponding biological cell, where N is an integer greater than or equal to 3; a step of automatic clustering of the points into different cell clusters depending on the measured cytometry parameters, so as to define a sample cluster file; and a step of comparing the sample cluster files with reference cluster files, each of the reference cluster files being defined from cytometry parameters of a respective pathological or abnormal biological sample.
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
37 - Services de construction; extraction minière; installation et réparation
38 - Services de télécommunications
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Computer hardware and equipment for laboratories in the
field of in-vitro diagnostics; software as services (SaaS)
for medical analysis laboratory professionals in the field
of in-vitro diagnostics. Advice regarding organization of medical analysis
laboratories; management and optimization of inventories of
products and consumables in the field of in-vitro
diagnostics; management (entry) of information regarding
data, analyses and technical reports from medical analysis
laboratories in the field of in-vitro diagnostics. Provision of maintenance, repair and troubleshooting
services, on-site or remotely, for in-vitro diagnostic
devices in the field of coagulation and cellular hematology
for analysis laboratories. Provision of access to Internet and extranet platforms
enabling medical analysis laboratories to access various
laboratory services in the field of in-vitro diagnostics. Training services in person or by means of distance learning
via an e-learning platform in the field of in-vitro
diagnostics. Laboratory quality assessment or quality auditing;
consulting services to medical analysis laboratories for
obtaining certification and accreditation. Assistance for interpretation of in-vitro diagnostic test
results in the field of coagulation and cellular hematology.
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
37 - Services de construction; extraction minière; installation et réparation
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer hardware and computer peripheral equipment, data processing equipment for laboratories in the field of in-vitro diagnostics Business organization advice in the field of medical analysis laboratories; Inventory management of products and consumables in the field of in-vitro diagnostics; Business information management, Computer data entry services relating to data, analyses and technical reports from medical analysis laboratories in the field of in-vitro diagnostics Provision of maintenance, repair and troubleshooting services in the nature of repair of in-vitro diagnostic devices in the field of coagulation and cellular hematology for analysis laboratories Provision of access to Internet and extranet platforms enabling medical analysis laboratories to access various laboratory services in the field of in-vitro diagnostics Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of medical laboratories; Consulting in the field of developing accreditation standards for medical analysis laboratories, testing, analysis and evaluation of medical analysis laboratories to determine conformity with established certification and accreditation standards
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
37 - Services de construction; extraction minière; installation et réparation
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Matériels informatiques de laboratoires dans le domaine du diagnostic in vitro; équipement de laboratoires dans le domaine du diagnostic in vitro, nommément agitateur magnétique; logiciels-services téléchargeables d'analyse de données destinés aux professionnels de laboratoires d'analyses médicales dans le domaine du diagnostic in vitro. (1) Conseils en organisation des laboratoires d'analyses médicales; services de gestion et optimisation des stocks de produits et consommables dans le domaine du diagnostic in vitro; gestion (saisie) d'informations de données, d'analyses et compte rendus techniques de laboratoires d'analyses médicales dans le domaine du diagnostic in vitro.
(2) Fourniture de services d'entretien, réparation et dépannage, sur place ou à distance, de dispositifs de diagnostic in vitro dans le domaine de la coagulation et de l'hématologie cellulaire pour les laboratoires d'analyses.
(3) Fourniture d'accès à des plateformes internet et extranet permettant aux laboratoires d'analyses médicales d'accéder à différents services de laboratoires dans le domaine du diagnostic in vitro.
(4) Service d'audit qualité ou évaluation de la qualité de laboratoire; services de conseils aux laboratoires d'analyses médicales pour l'obtention de certification et accréditation.
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
37 - Services de construction; extraction minière; installation et réparation
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer equipment and materials for laboratories in the field of in vitro diagnostics; Software as a service for professionals of medical analysis laboratories in the field of in vitro diagnostics. Business assistance and management services, administrative services for medical analysis laboratories in the field of in vitro diagnostics; Business organisation consultancy for medical analysis laboratories; Inventory management and optimisation for goods and consumables in the field of in vitro diagnostics. Providing of maintenance, repair and troubleshooting, on-site or remotely, of in vitro diagnostic devices in the field of coagulation and cellular haematology for analysis laboratories. Providing of access to internet and extranet platforms enabling medical analysis laboratories to access various laboratory services in the field of in vitro diagnostics. Management of information, data, analyses and technical reports from medical analysis laboratories in the field of in vitro diagnostics; Quality audit or quality assessment of laboratories; Advice to medical analysis laboratories for obtaining certification and accreditation.
24.
METHOD FOR DETECTING THE PRESENCE, IDENTIFICATION AND QUANTIFICATION IN A BLOOD SAMPLE OF ANTICOAGULANTS WHICH ARE INHIBITORS OF BLOOD COAGULATION ENZYMES, AND MEANS FOR THE IMPLEMENTATION THEREOF
in vitroin vitro method for detecting, in a biological sample, the presence of an inhibitor of a blood coagulation enzyme selected, independently, from factor Xa (FXa) and factor IIa (FIIa), the method implementing the measurement of one or more competition kinetics via the performance of a competitive enzyme assay and the implementation of one or more types of classification or regression decision models obtained by training one or more supervised machine learning models. The method may include the identification in the biological sample of a sought inhibitor, or even the characterisation or quantification (via a quantitative assay) thereof. The invention likewise relates to a data-processing system or device comprising means for implementing at least a part of the method according to the invention, a computer program or computer-readable recording medium or appropriate data, and a suitable kit.
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
Laboratory apparatus for medical diagnosis in vitro, namely,
equipment for sorting, centrifuging, transfer and automated
storage of samples (tubes for blood collection or other
types of biological media), to and from analyzers.
26.
Device for packaging balls for reaction vessels for an analysis appliance
Disclosed is a device for packaging balls for reaction vessels for an analysis appliance, including: a body including at least one opening and used to house balls, a closing member, that can be moved relative to the body between a closed position in which the closing member closes the opening of the body, and an open position in which the opening of the body is open so as to allow the balls to be dispensed from the body.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B65D 83/04 - Réceptacles ou paquets comportant des moyens particuliers pour distribuer leur contenu pour distribuer de petits objets en forme d'anneau, de disque, de sphère ou similaire, p. ex. des comprimés ou des pilules
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
Disclosed is a gripping device for a container intended for a biological analysis, including an annular part of X axis, elastically deformable gripping fins extending radially inwardly from the annular part, the fins being capable of being deformed when a container is introduced into the annular part, the fins being evenly distributed over the circumference. Each fin has a so-called upper surface and an opposite so-called lower surface, the lower surface being intended to come into contact with the container, the lower surface having a concave zone, or vice versa.
B01L 9/06 - Supports de tubes à essaiPorte-tubes à essai
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Products of chemical or biological origin to be used for
analyses, reactions, dosages, measurements and controls for
human and veterinary medicine. Apparatus for the automatic production of biological dosages
and measurements in the field of medical analysis for human
and veterinary medicine.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Products of chemical or biological origin to be used for
analyses, reactions, dosages, measurements and controls for
human and veterinary medicine. Apparatus for the automatic production of biological dosages
and measurements in the field of medical analysis for human
and veterinary medicine.
30.
METHOD FOR ANALYSING A BIOLOGICAL SAMPLE CONTAINING BIOLOGICAL CELLS, AND ANALYSING DEVICE FOR IMPLEMENTING THE ANALYSING METHOD
The invention relates to a method for analysing a biological sample containing biological cells, and an analysing device for implementing the analysing method. The analysing method comprises a step of measuring cytometry parameters for each biological cell contained in a biological sample; a step of determining, for each biological cell of the biological sample, a point in space with N dimensions, the coordinates of which are defined as a function of the cytometry parameters measured for the corresponding biological cell, wherein N is an integer greater than or equal to 3; a step of automatically grouping together the points in different clusters of cells as a function of the cytometry parameters measured, so as to define a sample cluster file; and a step of comparing the sample cluster file with reference cluster files, each of the reference cluster files being defined on the basis of cytometry parameters of a respective pathological or abnormal biological sample.
The invention relates to a method for analysing a biological sample containing biological cells, and an analysing device for implementing the analysing method. The analysing method comprises a step of measuring cytometry parameters for each biological cell contained in a biological sample; a step of determining, for each biological cell of the biological sample, a point in space with N dimensions, the coordinates of which are defined as a function of the cytometry parameters measured for the corresponding biological cell, wherein N is an integer greater than or equal to 3; a step of automatically grouping together the points in different clusters of cells as a function of the cytometry parameters measured, so as to define a sample cluster file; and a step of comparing the sample cluster file with reference cluster files, each of the reference cluster files being defined on the basis of cytometry parameters of a respective pathological or abnormal biological sample.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 15/10 - Recherche de particules individuelles
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Products of chemical or biological origin in the nature of in vitro diagnostic reagents for medicinal use for the automatic production of biological dosages and measurements in the field of medical analysis for human and veterinary medicine used in hemostasis to be used for analyses, reactions, dosages, measurements and controls for human and veterinary medicine Drug delivery systems, namely, apparatus for the automatic production of biological dosages and measurements in the field of medical analysis for human and veterinary medicine
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Products of chemical or biological origin in the nature of in vitro diagnostic reagents for medicinal use for the automatic production of biological dosages and measurements in the field of medical analysis for human and veterinary medicine used in haematology to be used for analyses, reactions, dosages, measurements and controls for human and veterinary medicine Drug delivery systems, namely, apparatus for the automatic production of biological dosages and measurements in the field of medical analysis for human and veterinary medicine
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Produits d'origine chimique ou biologique destinés à des analyses, réactions, dosages, mesures et contrôles pour la médecine humaine et vétérinaire, nommément préparations réactives pour le diagnostic médical.
(2) Appareils permettant la réalisation automatique des dosages biologiques dans le domaine de l'analyse médicale, nommément machines électroniques permettant de déterminer les dosages de l'hémostase et des facteurs de thrombose et de coagulation, automates d'analyse pour mesurer la coagulation sanguine et automates de coagulation de paillasse pour la réalisation automatique de tests sanguins chronométriques, colorimétriques et immuno-turbidimétriques.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Analysis, reaction, dosage, measurement and control of preparations of chemical or biological origin for human and veterinary medicine. Apparatus for automatic biological measurement and dosage in the field of medical analysis for human and veterinary medicine.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Analysis, reaction, dosage, measurement and control of preparations of chemical or biological origin for human and veterinary medicine. Apparatus for automatic biological measurement and dosage in the field of medical analysis for human and veterinary medicine.
Double bag having a first compartment containing a composition to be distributed and a second compartment for receiving a used fluid, a first bag connector communicating with the first compartment and serving to empty the latter, and a second bag connector communicating with the second compartment and serving to fill the latter.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B65D 77/06 - Liquides ou semi-liquides enfermés dans des réceptacles flexibles disposés dans des réceptacles rigides
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
The invention relates to a device for distributing cuvettes for a device for analysing biological samples including a fixed frame (2), a rotor (13) that is able to move in rotation with respect to the frame (2), said rotor (13) including a plate (16) that is intended to bear cuvettes, characterized in that the device includes means (28) for heating said cuvettes, said heating means including an electrical resistor (28) that is connected to electrical power supply means, said power supply means including a slip ring (30) comprising a fixed portion that is connected to an electrical power supply source and/or to monitoring and control means, and a movable portion that is electrically connected to the resistor.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
A method and kit for-, in particular, the medical and veterinary field, predicts and/or detects disseminated intravascular coagulation (DIC) in a biological sample.
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Chemical diagnostic reagents for medical use, for use in analysis of bodily fluids, for testing chemical biologic reactivity, for quantity determinations and for use as diagnostic controls in medical laboratories, all for use in human and veterinary medicine Measuring instruments for use in medical analysis in hospitals and private medical laboratories, namely, hemostasis analysers
41.
DEVICE FOR PACKAGING BALLS FOR REACTION VESSELS FOR AN ANALYSIS APPLIANCE
The invention relates to a device (20) for packaging balls for reaction vessels for an analysis appliance, comprising: a body (21) comprising at least one opening (27) and used to house balls, and a closing member (61) that can be moved, in relation to the body (21), between a closed position in which the closing member (61) closes the opening (27) of the body (21) and an open position in which the opening (27) of the body is open so as to allow the balls to be dispensed from the body (21).
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B65D 83/04 - Réceptacles ou paquets comportant des moyens particuliers pour distribuer leur contenu pour distribuer de petits objets en forme d'anneau, de disque, de sphère ou similaire, p. ex. des comprimés ou des pilules
42.
DEVICE FOR PACKAGING BALLS FOR REACTION VESSELS FOR AN ANALYSIS APPLIANCE
The invention relates to a device (20) for packaging balls for reaction vessels for an analysis appliance, comprising: a body (21) comprising at least one opening (27) and used to house balls, and a closing member (61) that can be moved, in relation to the body (21), between a closed position in which the closing member (61) closes the opening (27) of the body (21) and an open position in which the opening (27) of the body is open so as to allow the balls to be dispensed from the body (21).
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B65D 83/04 - Réceptacles ou paquets comportant des moyens particuliers pour distribuer leur contenu pour distribuer de petits objets en forme d'anneau, de disque, de sphère ou similaire, p. ex. des comprimés ou des pilules
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Preparations of chemical or biological origin for analyses, reactions, dosages, controls for human or veterinary medecine. Apparatus enabling automatic biological dosage in the field of medical analysis.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Biological chemical products for use in analyses, reactions,
assays, testing in laboratories, for human and veterinary
medicine, namely laboratory reagent for determination of the
factors of the exogenous pathway of blood coagulation, for
human and veterinary medicine.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Titrated blood plasma for laboratory testing of blood test
apparatus. Provision of access to an Internet site dedicated to the
compilation of blood test results, making available and
monitoring data regarding the comparative performance of
these blood testing laboratories via the Internet. Quality control of blood tests and assistance services for
blood testing laboratories to improve the quality of their
results.
46.
Method and device for determining the coagulation time of a blood sample, and reaction cuvette
This determination method comprises the steps consisting of providing a reaction vessel (2) containing a blood sample (33) and a ferromagnetic ball (11) placed on a raceway (9) provided in the bottom of the reaction vessel (2), subjecting the ball (11) to a magnetic field so as to move the ball along the raceway (9) in an oscillatory motion, exposing the blood sample to an incident light beam (36), detecting a light beam (38) transmitted through the reaction vessel (2) and coming from the incident light beam (36) in such a way as to provide a measurement signal, carrying out a first processing of the measurement signal in such a way as to provide a first signal representative of the variation of at least one physical quantity representative of the movement of the ball (11), carrying out a second processing of the measurement signal in such a way as to provide a second signal representative of the variation of at least one optical property of the blood sample, determining a first value of the coagulation time of the blood sample from the first signal, and determining a second value of the coagulation time of the blood sample from the second signal.
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 11/16 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement en déplaçant un corps à l'intérieur du matériau en mesurant l'effet d'amortissement sur un corps oscillant
G01N 11/00 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement
G01N 21/82 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un précipité ou une turbidité
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Biological chemical products for use in analyses, reactions, assays, testing in laboratories for human and veterinary medicine, namely, laboratory reagents in the nature of medical diagnostic reagents and veterinary diagnostic reagents for determination of the factors of the exogenous pathway of blood coagulation, for veterinary and medical purposes
05 - Produits pharmaceutiques, vétérinaires et hygièniques
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Plasma sanguin titré destiné à la réalisation de tests d'appareils d'analyse sanguine en laboratoire. (1) Fournitures d'accès à un site Internet dédié à la compilation de résultats d'analyse sanguine provenant de différents laboratoires d'analyse sanguine et à la mise à disposition d'informations relatives aux performances comparées de ces laboratoires d'analyse sanguine.
(2) Contrôle qualité d'analyses sanguines et services d'assistance de laboratoires d'analyse sanguine destinés à l'amélioration qualitative en matière d'analyse sanguine et de leurs résultats.
49.
UNIVERSAL CALIBRATION METHOD FOR THE DOSING OF ENZYMATIC INHIBITORS
The present invention relates to a universal calibration method for the dosing of inhibitors of a single enzyme, for example for the dosing of inhibitors of a blood coagulation enzyme. The invention also relates to the use of this universal calibration in a method for the dosing of a reversible or irreversible inhibitor of the enzyme in a biological sample. The invention further relates to the use of said universal calibration in a method for the screening of inhibitors of the enzyme.
C12Q 1/56 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des facteurs de coagulation du sang, p. ex. faisant intervenir la thrombine, la thromboplastine, le fibrinogène
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Produits chimiques biologiques destinés à des analyses, réactions, dosages, contrôles en laboratoire, pour la médecine humaine et vétérinaire, à savoir réactif de laboratoire destiné à doser les facteurs de la voie exogène de la coagulation sanguine, pour la médecine humaine et vétérinaire.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
(1) Educational services, namely programs and seminars in the field of coagulation testing and hemostasis application and online programs and seminars in the field of coagulation testing and hemostasis application and providing non-downloadable webinars in the field of coagulation testing and hemostasis applications.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, programs and seminars in the fields of coagulation testing and hemostasis applications in the nature of hemostasis procedures and hemostasis techniques, online programs and seminars in the fields of coagulation testing and hemostasis applications in the nature of hemostasis procedures and hemostasis techniques and providing non-downloadable webinars in the fields of coagulation testing and hemostasis applications in the nature of hemostasis procedures and hemostasis techniques
05 - Produits pharmaceutiques, vétérinaires et hygièniques
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Titrated blood plasma for the conducting of laboratory blood analysis apparatus tests. Providing of access to a website for compiling blood analysis results. Quality control of blood analysis and assistance for blood analysis laboratories for the qualitative improvement of their results; Providing and monitoring via the internet of data relating to the comparative performance of blood analysis laboratories.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Biological chemicals for use in analysis, reactions, dosages and tests in laboratories, for human and veterinary medicine, namely laboratory reagents for the dosing of factors for the exogenous blood coagulation pathway, for human and veterinary medicine.
56.
METHOD FOR ASSAYING D-DIMERS SPECIFIC TO VENOUS THROMBOEMBOLISM AND USE THEREOF FOR DIAGNOSING PULMONARY EMBOLISM AND DEEP VENOUS THROMBOSIS
The present invention relates to a method for assaying D-dimers that are specific to venous thromboembolism, resulting from the degradation of intravascular fibrin in a blood sample, including routine assay of D-dimers contained in the sample and dynamic measurement of fibrin formation in same. This method may be used to rule out pulmonary embolism or deep venous thrombosis in patients and/or to diagnose thrombosis or coagulation activation or thrombophilia in patients.
C12Q 1/56 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des facteurs de coagulation du sang, p. ex. faisant intervenir la thrombine, la thromboplastine, le fibrinogène
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
The present invention relates to a method for predicting and/or detecting disseminated intravascular coagulation (DIC) in a biological sample, and a kit for predicting and/or detecting disseminated intravascular coagulation (DIC) in a biological sample. The invention has application, in particular, in the medical and veterinary field.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Transmission of internal quality control data relating to comparative performance of blood analysis results via the Internet Providing a website featuring information regarding the compilation of internal quality control results; Monitoring data relating to comparative performance of blood analysis results for quality control purposes; Quality control of blood analysis for others and quality control assistance for blood analysis laboratories for the qualitative improvement of their results
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Biological chemical products used for analyses, reactions,
assays, testing in laboratories, for human and veterinary
medicine, namely laboratory reagents for assaying the
factors of the endogenous pathway of blood coagulation, for
human and veterinary medicine.
63.
Method for determining the position of a fixed cartography token including deducing coordinate points of the cartography token with respect to movement of a needle
a) of the base (11), the stud (15) including an end face (16) opposite the base (11). The method is aimed in particular at deducing the coordinates (XO, YO, ZO) of at least one point (O) of the cartography token (10) with respect to a movable member.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Diagnostic instruments for use in hospital or private
medical analysis laboratories, namely semi-automated testing
devices for measuring blood coagulation.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Non-titrated blood plasma for the conducting of laboratory tests of blood analysis apparatus. Providing of access to a website for the compilation of blood analysis results, providing and monitoring via the internet of data relating to comparative performance of the aforesaid blood analysis laboratories. Quality control of blood analysis and assistance for blood analysis laboratories for the qualitative improvement of their results.
67.
METHOD AND DEVICE FOR DETERMINING THE COAGULATION TIME OF A BLOOD SAMPLE, AND REACTION VESSEL
This determination method comprises the steps consisting of providing a reaction vessel (2) containing a blood sample (33) and a ferromagnetic ball (11) placed on a raceway (9) provided in the bottom of the reaction vessel (2), subjecting the ball (11) to a magnetic field so as to move the ball along the raceway (9) in an oscillatory motion, exposing the blood sample to an incident light beam (36), detecting a light beam (38) transmitted through the reaction vessel (2) and coming from the incident light beam (36) in such a way as to provide a measurement signal, carrying out a first processing of the measurement signal in such a way as to provide a first signal representative of the variation of at least one physical quantity representative of the movement of the ball (11), carrying out a second processing of the measurement signal in such a way as to provide a second signal representative of the variation of at least one optical property of the blood sample, determining a first value of the coagulation time of the blood sample from the first signal, and determining a second value of the coagulation time of the blood sample from the second signal.
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 11/10 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement en déplaçant un corps à l'intérieur du matériau
Method for determining the coagulation time of a blood sample, comprising a reaction well containing the sample. The well comprises a base defining a raceway. Place a ferromagnetic bead on the raceway. Submit the bead to a magnetic field to move the bead in an oscillating movement. Expose the sample to a beam of light. Detect at least one beam of light so as to provide a measurement signal. Carry out a first processing so as to provide a first signal representative of the variation of at least one physical size representative of the movement of the bead. Carry out a second processing of the signal so as to provide a second signal representative of the variation of at least one optical property of the sample. Determine a first coagulation time of the sample from the first signal and a second coagulation time of the sample from the second signal.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Biological chemicals for use in analyses, reactions, dosing and tests in laboratories, for human and veterinary medicine, namely laboratory reagents for the dosing of factors for the endogenous blood coagulation pathway, for human and veterinary medicine.
(1) Instruments de diagnostic destinés aux laboratoires d'analyses médicales privés ou hospitaliers, à savoir automates d'analyse pour mesurer la coagulation sanguine
(1) Instruments de diagnostic destinés aux laboratoires d'analyses médicales privés ou hospitaliers, à savoir semi-automates d'analyse pour mesurer la coagulation sanguine.
72.
METHOD FOR DETERMINING THE STRUCTURAL PROFILE OF A FIBRIN CLOT REFLECTING THE STABILITY THEREOF, IN ORDER TO PREDICT THE RISK OF BLEEDING, THROMBOSIS OR RETHROMBOSIS
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - (France)
UNIVERSITE GRENOBLE I JOSEPH FOURIER (France)
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (France)
Inventeur(s)
Contant, Geneviève
Polack, Benoît
Caton, François
Dassi, Carhel
Abrégé
The present invention relates to a method for dynamically determining the structural profile of a fibrin clot, reflecting the stability thereof in a biological sample of a patient, said method comprising the following steps: a) mixing the undiluted biological sample with tissue factor or a mixture of tissue factor and tissue plasminogen activator; b) incubating the mixture obtained in step a), then adding calcium ions to the mixture obtained, in order to initiate the formation of a fibrin clot; c) measuring the turbidity or the optical density of the clot being formed in step b), at at least two wavelengths of between 450 nm and 850 nm, and for a time of between 1 and 35 minutes; d) determining the structural profile of the analysed clot, expressed as a number of protofibrils, density and radius in c) by means of the formula τ.λ5 = A [Fg].(λ2 - B), wherein τ is the turbidity of the clot at a given wavelength λ, [Fg] is the initial weight concentration of fibrinogen, and A and B are coefficients which are proportional, respectively, to the density and the radius of the fibres that make up the clot; and e) comparing the obtained profile with a control. The method preferably includes a step f) that makes it possible to predict the risk of bleeding, thrombosis or rethrombosis and to select the anticoagulant that is best suited to the clinical situation of a patient.
The invention relates to a method of determining the position of at least one fixed cartography token (10) of an automaton, said token (10) comprising a base (11) comprising a lateral surface and an end face (14a), a stud (15) of smaller cross section than the base (11) projecting from the end face (14a) of the base (11), said stud (15) comprising an end face (16) opposite the base (11). The method is aimed in particular at deducing the coordinates (XO, YO, ZO) of at least one point (O) of the cartography token (10) with respect to a movable member.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Produits réactifs d'origine chimique, biologique destinés à des analyses, réactions, dosages, contrôle en laboratoires pour la médecine humaine et vétérinaire.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Appareils permettant la réalisation automatique des dosages biologiques dans le domaine de l'analyse médicale, nommément machines électroniques permettant de déterminer les dosages de l'hémostase et des facteurs de thrombose et de coagulation, automates d'analyse pour mesurer la coagulation sanguine et automates de coagulation de paillasse pour la réalisation automatique de tests sanguins chronométriques, colorimétriques et immuno-turbidimétriques.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Appareils permettant la réalisation automatique des dosages biologiques dans le domaine de l'analyse médicale, nommément machines électroniques permettant de déterminer les dosages de l'hémostase et des facteurs de thrombose et de coagulation, automates d'analyse pour mesurer la coagulation sanguine et automates de coagulation de paillasse pour la réalisation automatique de tests sanguins chronométriques, colorimétriques et immuno-turbidimétriques.
A reaction vessel for an automatic chemical or biological analysis appliance includes a connection part (22) for connection to another vessel (10) of the same type, the connection part is resiliently snap-fastened on the top end of the vessel (10) and is also resiliently snap-fastened to the connection part (22) of another vessel so as to form a string of vessels that are hinged to one another about transverse axes (xx)′.
The invention relates to a device (31) for storing reaction vessels, intended for being mounted on an automatic analysis appliance, comprising a row of vessels attached to a flexible belt wound about a hub (1), one end of the belt being connected to the hub (1), the other end of the belt being connected to a reel (12) intended for winding up the empty belt after the vessels have separated. The storage device (31) comprises a substrate (33) on which the hub (1) and the reel (12) are mounted such as to maintain a predetermined centre-to-centre distance therebetween.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Biochemical preparations for scientific use for in vitro and in vivo use in laboratory analyses, reactions assays, and tests for human and veterinary use
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Chemical and biological preparations for use in analyses, reactions and laboratory tests for human and veterinary medicine. Chemical and biological preparations for use in dosages, for human and veterinary medicine.
97.
REACTION VESSEL FOR AN AUTOMATIC CHEMICAL OR BIOLOGICAL ANALYSIS DEVICE
The invention relates to a reaction vessel for an automatic chemical or biological analysis device. The vessel of the invention comprises a part (22) for connecting same to another vessel (10) of the same type, said connecting part being elastically snap fastened to the upper end of the vessel (10) and to the connecting part (22) of another vessel, in order to form a row of vessels hinged to one another about transverse axes (xx').