An administration system for delivery of a pharmaceutical composition to a patient has a delivery device configured to deliver a dose of the pharmaceutical composition to the patient and a notification device in communication with the delivery device. The notification device is configured to communicate information about a status of at least one property of the delivery device. The delivery device can be a wearable automatic injector configured to be worn on the patient's skin. The delivery device of the present disclosure may allow a user or the patient to view a status of a container. For example, the delivery device of the present disclosure may provide a simple and effective visual means of displaying fill confirmation and delivery confirmation.
A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/148 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons flexibles
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
Water-soluble fluorescent polymeric dyes and polymeric tandem dyes are provided. The polymeric dyes include a water solvated light harvesting multi-chromophore having a conjugated segment of aryl and/or heteroaryl co-monomers. The molar ratio of the co-monomers can be adjusted to provide beneficial technical properties, such as increased water solubility and improved absorption and emission spectra. For instance, the conjugated segment can have a first co-monomer substituted with a water-soluble group (WSG) and a second co-monomer, wherein the first co-monomer is in an amount that is equal or greater than the amount of the second co-monomer. multi-chromophore. The polymeric tandem dyes further include a signaling chromophore covalently linked to the multi-chromophore in energy-receiving proximity therewith. Also provided are aggregation-resistant labelled specific binding members that include the subject water-soluble polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.
Integrated optofluidic interrogation modules are provided. Integrated optofluidic interrogation modules of interest include a flow cell comprising a light-accessible flow channel for transporting particles in a flow stream, a linear fiber array integrated with the flow cell and comprising a plurality of non-circular core optical fibers each configured to project excitation wavelength light onto a corresponding focal spot within the flow cell, and a plurality of fiber optic light conveyor couplers for operably attaching a plurality of light sources to the linear fiber array. Also provided are flow cytometers comprising the subject integrated optofluidic interrogation modules, as well as methods of use thereof.
Disclosed herein include methods, compositions, and kits suitable for use in generating libraries for nucleic acid sequencing. There are provided, in some embodiments, a plurality of protein complexes. Each protein complex can comprise a transposome and a programmable DNA binding unit capable of specifically binding to a user-selected binding site on a target double-stranded DNA (dsDNA). The binding site for each of the plurality of protein complexes can be different from each other. The transposome can comprise a transposase, a first adaptor, and a second adaptor. The first adaptor, the second adaptor, or both, can be a sequencing adaptor.
A securement device for a vascular access device includes a base including a first end, a second end, a first side, a second side, a top surface, and a bottom surface positioned opposite the top surface, with the bottom surface configured to be in contact with a patient's skin surface, a first securing member including a first end connected to the base and a second end opposite from the first end, the second end moveable relative to the base. The first securing member defines a first opening configured to receive a first portion of the vascular access device, and a second securing member includes a first end connected to the base and a second end positioned opposite the first end, the second end moveable relative to the base and the second securing member defining a second opening configured to receive a second portion of the vascular access device.
A nest configured to support medical containers is provided. The nest includes a support plate comprising a first surface, a second surface, and a peripheral edge between the first surface and the second surface, with the support plate configured as a frame-shaped plate having a hollow interior area. The nest also includes a plurality of chimneys extending outwardly and away from the first surface that define receptacles configured to receive medical containers therein. The chimneys include an interior chimney group positioned in the hollowed interior area of the frame-shaped plate and a perimeter chimney group surrounding the interior chimney group, with each of the perimeter chimneys at least partially joined to an inner edge of the frame-shaped plate at the bottom end thereof. The nest further includes reinforcing ribs extending between the plurality of chimneys that connect each respective chimney to a plurality of adjacent chimneys.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A container is disclosed, including a bag defining a first end, a second end, an exterior surface, and an interior cavity; a connector defining a first end, a second end, and a passage therethrough, wherein the first end of the connector is attached to the first end of the bag, and the passage is in fluid communication with the interior cavity; and a cover attached to at least one of the bag and the connector, wherein the cover is transitionable from a first configuration where the cover surrounds at least a portion of the exterior surface of the bag, to a second configuration where the cover encloses the second end of the connector.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61L 2/07 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques de la chaleur des gaz chauds de la vapeur
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
A medical device includes a container defined by walls and having a first end having an opening. The opening is sealed by a rubber component. The rubber component is formed from a self-lubricating rubber formed from a rubber composition including a halogenated isobutylene-isoprene co-polymer and at least one of (1) clay minerals or silica and (2) a liquid polyisoprene and butadiene homopolymer. A rubber component configured for use in a medical device and a rubber composition are also disclosed.
A61J 1/05 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques pour recueillir, stocker ou administrer du sang, du plasma ou des liquides à usage médical
A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques DétailsAccessoires à cet effet
A medication delivery device includes an infusion pump system having a reservoir, a fluid path connected between the reservoir and an insertion mechanism, a plunger arranged inside the reservoir, and a pump drive mechanism coupled with the reservoir. The medication delivery device further includes a processing device configured to determine a user fill volume of a fluid medication by analyzing a location of the plunger inside the reservoir when a fill of the fluid medication is completed. The processing device is configured to determine the user fill volume of the fluid medication by sensing a pressure inside the reservoir.
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A device for connection to a medical connector, the device includes a cap body, a coupling cylinder adapted to engage with a male luer connector and a female luer connector, a bulb compartment filled with air, a reagent compartment filled with disinfectant or an antimicrobial reagent, and a passageway connecting the bulb compartment to the reagent compartment. The reagent compartment includes an exterior wall surface, an interior wall surface, an array of resealable pores densely integrated throughout the exterior wall surface and the interior wall surface of the reagent compartment, and a distal tip. The passageway may be positioned in an aperture of the proximal wall of the cap body. The coupling cylinder may include an O-ring.
Provided herein is a wearable drug delivery device including a housing having a perimeter and defining an interior, the housing having first and second ports arranged on an external surface thereof, a needle moveable between a first position in which the needle is received entirely within the housing interior and a second position in which at least a portion of the needle extends through the first port, a button arranged on the external surface of the housing, the button configured to cause the needle to move from the first position to the second position, a cannula arranged about an exterior of the needle, a pump received within the housing interior, the pump in fluid communication with the cannula, a reservoir arranged outside of the housing interior and offset from the housing perimeter, the reservoir in fluid communication with the second port and the pump.
A medical device includes a container defined by walls and having a first end having an opening. The opening is sealed by a rubber component. The rubber component is formed from a self-lubricating rubber formed from a rubber composition including a halogenated isobutylene-isoprene co-polymer and at least one of (1) clay minerals or silica and (2) a liquid polyisoprene and butadiene homopolymer. A rubber component configured for use in a medical device and a rubber composition are also disclosed.
The present disclosure relates to an automatic injection device, comprising a first assembly for receiving a syringe, and a second assembly coupled with the first assembly. The second assembly includes: an outer casing; a driving mechanism placed within the outer casing and capable of being loaded and released, wherein when loaded, the driving mechanism stores energy, and when released, the driving mechanism drives the movable element of the syringe towards the injection site by releasing energy; a retaining mechanism placed within the outer casing, the retaining mechanism including a retaining position and a releasing position; and a trigger mechanism positioned at a first end of the outer casing and configured to move the retaining mechanism from the retaining position to the releasing position to release the loaded driving mechanism.
A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
A61M 5/24 - Seringues à ampoules, c.-à-d. seringues à aiguille utilisables avec des ampoules ou des cartouches échangeables, p. ex. automatiques
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
A self-healing membrane includes a material having a molecular weight greater than 35 k Da, at least 50% by weight of mineral oil, at least 40% styrenic block copolymer, and 0-10% polypropylene. The membrane may be utilized in any component of a closed system transfer device or system, such as a syringe adapter, patient connector, vial adapter, IV bag spike, etc. The membrane may also be utilized in other medical device components and, more specifically, medical device components where the membrane is punctured by a needle.
Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).
G01N 1/44 - Traitement d'échantillons mettant en œuvre un rayonnement, p. ex. de la chaleur
G01N 15/075 - Recherche de la concentration des suspensions de particules par des moyens optiques
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
An integrated disinfecting device assembly is described syringe assembly having two integrated disinfection units assembled to a syringe for disinfecting and sterilizing corresponding medical connectors, specifically access ports of corresponding medical connectors. The integrated disinfection units include a Needleless Connector Disinfecting Unit (NCDU) and a Male Luer Disinfecting Unit (MLDU) disposed on a syringe assembly. The NCDU having a first chamber containing a first absorbent material, a first disinfectant or an antimicrobial agent in the first housing, and a first peelable seal. The MLDU for a male medical connector comprising a housing, a scrubbing foam having a plurality of slits disposed within a first cavity of the housing, a central post extending from the closed bottom of the housing and positioned within the first cavity of the housing, a scrubbing foam disposed around within the inner surface of the integral body, a foam jacket disposed on the central post and having a plurality of slits, a central plug disposed in the center of the central post extending from the top wall of the central post and extending into the second cavity of the foam jacket, a second disinfectant or an antimicrobial agent in the, and a second peelable seal. The inner surface of the foam jacket defines a second cavity. A threaded connection is disposed on the bottom exterior surface of the first scrubbing device having threads that are sized and pitched to engage threads of a luer lock collar on the distal end of the syringe barrel to allow the proximal housing to be connected to the syringe assembly. The MLDU and the syringe assembly are integrally connected at the thumb press of the syringe and ledge of the MLDU. In one or more embodiments, the MLDU and the syringe assembly are interlocked through interference fit or snap fit of the thumb press of the syringe and ledge of the MLDU.
A61M 39/16 - Raccords ou accouplements pour tubes avec des dispositions pour la désinfection ou la stérilisation
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A reusable motorized auto-injection device comprises: a single motor; a motion conversion mechanism; a drive shaft configured to be driven by said motion conversion mechanism to move linearly; and a loading sleeve configured to receive a syringe containing a medication; wherein the motion conversion mechanism comprises an outer sleeve and an inner shaft disposed within the outer sleeve, wherein a thread is provided on one of the outer wall of the inner shaft and the inner wall of the outer sleeve, and an engagement element is provided on the other, and wherein the thread includes a first section and a second section having a continuous thread groove, the first section and the second section having different pitches, the engagement element being configured to be able to engage successively with respective thread groove of the first section and the second section in such a way that, when engaging with the thread groove of the first section, the drive shaft is moved linearly at a first, faster speed to realize rapid insertion of the needle of the syringe, and when engaging with the thread groove of the second section, the drive shaft moves linearly at a second, slower speed to realize a slow infusion of the medication of the syringe.
A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
A61M 5/46 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour commander la profondeur de pénétration
20.
PROTECTIVE COVER FOR CONTAINER FOR TRANSFER OF STERILIZED COMPONENTS
A container is configured for transfer of sterilized components from the container into a sterile chamber through a transfer port. The container includes a flexible bag defining an interior cavity, and a connection flange connected to the flexible bag. The connection flange has an opening for accessing the interior cavity of the flexible bag. An access door is connected to the connection flange for sealing the opening. The container includes a protective cover removably connectable to the connection flange and at least partially covering the access door. The protective cover is transparent to permit viewing of the access door.
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
B65D 55/08 - Éléments annulaires encerclant les cols des réceptacles
B65B 55/02 - Stérilisation, p. ex. de paquets finis
B65D 51/18 - Aménagements des fermetures avec couvercles extérieurs de protection analogues à des capuchons ou de plusieurs fermetures conjuguées
B65D 51/20 - Capuchons, couvercles ou chapeaux fonctionnant avec une fermeture intérieure disposée pour être ouverte en perçant, coupant ou déchirant
B65D 75/58 - Dispositifs d'ouverture ou servant à retirer le contenu, ajoutés ou incorporés lors de la confection du paquet
A61L 2/07 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques de la chaleur des gaz chauds de la vapeur
A reusable motorized auto-injection device includes a housing; a single motor within said housing; a drive shaft configured to move linearly; a sleeve configured to receive a syringe containing a medication; and a circuit switcher, wherein said drive shaft is configured to engage a stopper of said syringe, and wherein said circuit switcher is configured to automatically cause said motor to operate in a first mode and in a second mode successively with the linear movement of said drive shaft, wherein in said first mode, said motor is connected to a first circuit such that said drive shaft is linearly moved at a first, faster speed, thereby realizing rapid insertion of a needle of said syringe, and wherein in said second mode, said motor is connected to a second circuit such that said drive shaft is linearly moved at a second, slower speed, thereby realizing a slow infusion of medication.
A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
A61M 5/24 - Seringues à ampoules, c.-à-d. seringues à aiguille utilisables avec des ampoules ou des cartouches échangeables, p. ex. automatiques
A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
A nest for the storage of medical device components is provided. The nest includes a main wall having a top surface and a bottom surface and a plurality of chimneys for the storage of a plurality of medical device components therein. Each of the chimneys includes a sidewall extending downward from the bottom surface of the nest to define the chimney, with each of the chimneys having an upper opening and a lower opening. The sidewall of each of the chimneys has a top sidewall portion and a bottom sidewall portion, with a dividing point separating the top sidewall portion and the bottom sidewall portion. A diameter of the chimney at the dividing point is less than a diameter of the upper opening and less than a diameter of the lower opening.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61B 50/20 - Équipements de support spécialement adaptés aux appareils ou aux instruments chirurgicaux ou de diagnostic
09 - Appareils et instruments scientifiques et électriques
Produits et services
Computer software; Data visualization software; software for use in visualizing and analyzing RNA and DNA sequencing data; computer software for research laboratory purposes; Reagents for use with single cell multiomics research use; laboratory instrument and apparatus, namely, single-cell gene expression platform used to capture and analyze individual cells; laboratory equipment.
09 - Appareils et instruments scientifiques et électriques
Produits et services
(1) Computer software; Data visualization software; software for use in visualizing and analyzing RNA and DNA sequencing data; computer software for research laboratory purposes; Reagents for use with single cell multiomics research use; laboratory instrument and apparatus, namely, single-cell gene expression platform used to capture and analyze individual cells; laboratory equipment
25.
Blood Collection Adapter and Related Systems and Methods
A catheter system may include a catheter adapter, which may include a distal end, a proximal end, and a lumen extending through the distal end of the catheter adapter and the proximal end of the catheter adapter. The catheter system may include a catheter extending distally from the distal end of the catheter adapter. The catheter system may include a connector coupled to the catheter adapter and comprising a septum. The catheter system may include a blood collection adapter coupled to the connector. The blood collection adapter may be configured to create a fluid path through the connector. The catheter system may include a blood collection set coupled to the blood collection adapter. The blood collection set may include a needle assembly configured to receive a blood collection container.
A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
A61B 5/153 - Dispositifs de prélèvement d'échantillons de sang spécialement adaptés pour le prélèvement d'échantillons de sang veineux ou artériel, p. ex. par des seringues
A61M 39/00 - Tubes, raccords ou accouplements pour tubes, soupapes, voies d'accès ou similaires, spécialement adaptés pour un usage médical
Outlet fittings are provided. Outlet fittings of interest include an elongate structure and an opening at a proximal end for receiving a flow stream from the distal end of a flow cell. In addition, the outlet fittings described herein are configured to reduce the formation of bubbles at the interface between the outlet fitting and the flow cell. In certain cases, outlet fittings do not include a planar surface in contact with the received flow stream. Flow cytometers and methods employing the subject outlet fittings are also provided.
Provided herein is a method for modifying a surface texturing of an injection needle. The method includes positioning one or more injection needles onto a support tool, each of the one or more injection needles comprising a cylindrical needle body having a distal end and a proximal end and defining a lumen therein. The method also includes directing lasers from one or more laser sources onto an outer surface of the needle body of each of the one or more injection needles. The lasers form a pattern of depressions in the outer surface of the needle body of each of the one or more injection needles, to form a textured outer surface on the one or more injection needles.
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
28.
SORTING OF MRNA AND/OR ABSEQ CONTAINING BARCODED BEADS BY FLOW
Disclosed herein include systems, methods, compositions, and kits for reducing non-specific noise-causing oligonucleotides in library preparations. Capture particles present in PCR reactions that are derived from partitions that did not contain a cell (e.g., noise capture particles) provide a significant source of non-specific nucleic acid and noise in single cell multiomics library preparations. In some embodiments of the methods provided herein, said noise capture particles are removed by a variety of approaches.
Disclosed herein include systems, methods, compositions, and kits for associating single cell sequencing data with imaging data (e.g., phenotypic data). In some embodiments, particle indexing oligonucleotides are associated with reference particles. Reference particles can comprise one or more detectable moieties. The particle indexing oligonucleotide can comprise a particle type identifier (PTI) and a unique particle identifier (UPI). The PTI and the UPI can be employed to identify of the imaged partition from which a sequenced nucleic acid target molecule originated.
Provided herein is a method for modifying a surface texturing of an injection needle. The method includes positioning one or more injection needles onto a support tool, each of the one or more injection needles comprising a cylindrical needle body having a distal end and a proximal end and defining a lumen therein. The method also includes directing lasers from one or more laser sources onto an outer surface of the needle body of each of the one or more injection needles. The lasers form a pattern of depressions in the outer surface of the needle body of each of the one or more injection needles, to form a textured outer surface on the one or more injection needles.
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
A61M 5/34 - Structures pour le raccordement de l'aiguille
B23K 26/352 - Travail par rayon laser, p. ex. soudage, découpage ou perçage pour le traitement de surface
A flush syringe with a syringe coupler facilitates twice dispensing of intravenous flushing solution to a patient's vascular access device (VAD), with reduced risk of VAD infection. The syringe coupler incorporates a female, first Luer connector on its proximal end that is removably coupled to the male, barrel Luer connector of the syringe, isolating the latter connector from external contamination. The syringe coupler also has a single-use, male, second Luer connector on its distal end of the housing that is adapted for coupled insertion into the patient's VAD, for delivery of at least a portion of the flushing solution retained within the syringe. After the first delivery, the syringe coupler is de-coupled from both the VAD and the syringe. Thereafter, the syringe's unused, sterile, male, barrel Luer connector is directly coupled to the VAD for dispensing the second portion of the flushing solution.
A flush syringe with a syringe coupler facilitates twice dispensing of intravenous flushing solution to a patient's vascular access device (VAD), with reduced risk of VAD infection. The syringe coupler incorporates a female, first Luer connector on its proximal end that is removably coupled to the male, barrel Luer connector of the syringe, isolating the latter connector from external contamination. The syringe coupler also has a single-use, male, second Luer connector on its distal end of the housing that is adapted for coupled insertion into the patient's VAD, for delivery of at least a portion of the flushing solution retained within the syringe. After the first delivery, the syringe coupler is de-coupled from both the VAD and the syringe. Thereafter, the syringe's unused, sterile, male, barrel Luer connector is directly coupled to the VAD for dispensing the second portion of the flushing solution.
Provided herein is a wearable drug delivery device including a housing having a skin-facing surface defining a cannula opening, and a viewing window, a container disposed within the housing and configured to store the pharmaceutical composition therein, a cannula in fluid communication with the container, the cannula transitionable from an initial position in which the cannula is disposed within the housing to a use position in which the cannula extends through the cannula opening, a visual identifier aligned with a portion of the viewing window, wherein a position of the visual identifier relative to the viewing window is dependent on a volume of the pharmaceutical composition within the container, a thermoelectric generator configured to supply power to the drug delivery device, wherein the housing is configured to be releasably attached to a patient's skin.
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/148 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons flexibles
35.
METHOD FOR SEPARATING GENOMIC DNA FOR AMPLIFICATION OF SHORT NUCLEIC ACID TARGETS
Disclosed herein include methods, compositions, and kits for use in detecting a target nucleic acid sequence in a sample. Provided include acidic compositions for separating dsDNA. In some embodiments, the acidic compositions comprise a monovalent salt and/or a divalent salt, one or more surfactants, and an acidic agent. In some embodiments, the pH of the acidic composition is less than 4. Also provided herein are reagent compositions comprising a buffering agent and one or more amplification agents.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
Disclosed herein include methods, compositions, and kits for use in detecting a target nucleic acid sequence in a sample. Provided include storage-stable lysis buffers. In some embodiments, the lysis buffer comprises: one or more surfactants and magnesium sulfate (MgSO4). In some embodiments, the formation of a precipitate (for example, a complex of Mg+2 and the one or more surfactants) is substantially inhibited for a period of time under at least one storage condition.
A multi-chamber package is described including a first and second chamber, the first chamber having a bottom wall and sidewalls defining a cavity, the second chamber having a partially open bottom wall and sidewalls defining a cavity. A first removable seal is positioned over a top surface of the package, fully covering the first chamber and second chamber, and a second seal is positioned over a bottom surface of the partially open floor of the second chamber, fully sealing the second chamber. A method of packaging medical devices is also described.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A flexible reservoir in a fluid delivery device is arranged with a conformal member to prevent premature collapse of the flexible reservoir as fluid is removed therefrom by a pumping mechanism. The conformal member is arranged to abut the reservoir and comprises a material that allows the conformal member to conform to at least part of the reservoir, to compress as fluid is supplied to the reservoir, and decompress and fluid is removed from the reservoir. The conformal member material can be an elastomeric foam, and can be pre-loaded with respect to compression relative to the reservoir. The flexible reservoir and the conformal member can be arranged in a shell of one or more rigid or semi-rigid parts that at least partially surrounds the flexible reservoir and the conformal member or fully surrounds them.
A flush syringe with a syringe coupler facilitates twice dispensing of intravenous flushing solution to a patient's vascular access device (VAD), with reduced risk of VAD infection. The syringe coupler incorporates a female, first Luer connector on its proximal end that is removably coupled to the male, barrel Luer connector of the syringe, isolating the latter connector from external contamination. The syringe coupler also has a single-use, male, second Luer connector on its distal end of the housing that is adapted for coupled insertion into the patient's VAD, for delivery of at least a portion of the flushing solution retained within the syringe. After the first delivery, the syringe coupler is de-coupled from both the VAD and the syringe. Thereafter, the syringe's unused, sterile, male, barrel Luer connector is directly coupled to the VAD for dispensing the second portion of the flushing solution.
A61M 39/00 - Tubes, raccords ou accouplements pour tubes, soupapes, voies d'accès ou similaires, spécialement adaptés pour un usage médical
A61M 5/50 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour empêcher la réutilisation ou pour indiquer si le dispositif est défectueux, usagé, non stérile ou si l'on a tenté de l'utiliser
A flush syringe with a syringe coupler facilitates twice dispensing of intravenous flushing solution to a patient's vascular access device (VAD), with reduced risk of VAD infection. The syringe coupler incorporates a female, first Luer connector on its proximal end that is removably coupled to the male, barrel Luer connector of the syringe, isolating the latter connector from external contamination. The syringe coupler also has a single-use, male, second Luer connector on its distal end of the housing that is adapted for coupled insertion into the patient's VAD, for delivery of at least a portion of the flushing solution retained within the syringe. After the first delivery, the syringe coupler is de-coupled from both the VAD and the syringe. Thereafter, the syringe's unused, sterile, male, barrel Luer connector is directly coupled to the VAD for dispensing the second portion of the flushing solution.
Disclosed herein include methods, kits, and reaction mixtures suitable for use in monitoring an amplification reaction. Some embodiments provide a first and a second quality control primer capable of hybridizing to each other and each comprising a quenchable label or a quencher.
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
43.
Equipment Kit and Container With Tools for Performing Blood Draw Procedures and Methods of Use
A container configured to store tools used by a healthcare worker when performing a blood draw and collection procedure includes a tray and packaging. The tray includes a plurality of chambers sized to receive the tools used by the healthcare worker for the blood draw and collection procedure. The tools include at least one disposable disinfecting device for disinfecting portions of the tools and at least one tube for storing a blood sample. The packing, when in a closed or prior-to-use position, is over openings of the plurality of chambers of the tray, thereby securely containing the tools within the chambers of the tray. In an open or ready-for-use position, the packaging is separated from the openings of the plurality of chambers of the tray so that the healthcare worker can access the tools contained within the chambers while performing the blood draw and collection procedure.
A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
A61B 5/153 - Dispositifs de prélèvement d'échantillons de sang spécialement adaptés pour le prélèvement d'échantillons de sang veineux ou artériel, p. ex. par des seringues
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A storage container having a base storage compartment configured to receive a divider by which the storage compartment is divided into two or more sub-compartments, wherein divider includes a tool configured to provide a secondary utility or function unrelated to dividing the storage compartment.
F16K 15/02 - Soupapes, clapets ou valves de retenue à corps de soupapes rigides guidés
F16K 15/03 - Soupapes, clapets ou valves de retenue à corps de soupapes rigides guidés et élément de fermeture à charnière
F16K 15/16 - Soupapes, clapets ou valves de retenue à corps de soupapes flexibles à lamelles en forme de langue
G05D 7/01 - Commande de débits sans source d'énergie auxiliaire
45.
FORCE SENSING RESISTOR FOR LIQUID LOW-VOLUME DETECTION AND OCCLUSION SENSING AND METHODS AND APPARATUSES FOR FLOW SENSING ALONG FLUID PATH IN FLUID DELIVERY DEVICE
An apparatus is provided for detecting fluid low-volume and occlusion in a device using a sensor. One or more force sensing resistors are positioned in communication with a fluid channel at one or more of a pump intake and pump outlet to detect pressure in the fluid channel. The pressure is detected through communication with the force sensing resistor and indicates an irregular system condition including but not limited to, fluid low-volume level and occlusion. Also provided are a fluid flow sensor (e.g., FSR or MEMS sensor) disposed relative to an embedded fluid channel in the base of a wearable medicine delivery pump.
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
G01F 1/696 - Circuits à cet effet, p. ex. débitmètres à courant constant
G01L 1/20 - Mesure des forces ou des contraintes, en général en mesurant les variations de la résistance ohmique des matériaux solides ou des fluides conducteurs de l'électricitéMesure des forces ou des contraintes, en général en faisant usage des cellules électrocinétiques, c.-à-d. des cellules contenant un liquide, dans lesquelles un potentiel électrique est produit ou modifié par l'application d'une contrainte
G01L 9/02 - Mesure de la pression permanente, ou quasi permanente d’un fluide ou d’un matériau solide fluent par des éléments électriques ou magnétiques sensibles à la pressionTransmission ou indication par des moyens électriques ou magnétiques du déplacement des éléments mécaniques sensibles à la pression, utilisés pour mesurer la pression permanente ou quasi permanente d’un fluide ou d’un matériau solide fluent en faisant usage des variations de la résistance ohmique, p. ex. de potentiomètre
A metering pump for a medical injector includes a housing, a sleeve at least partially received within the housing, a piston at least partially received within the sleeve, with the piston and the sleeve defining a chamber, and an interlock member. The piston having a first position where the chamber has a first volume and a second position where the chamber has a second volume. The sleeve has a first rotational position where an inlet is in fluid communication with the chamber, a second rotational position where an outlet is in fluid communication with the chamber, and a third rotational position where the inlet and outlet are isolated from the chamber. The interlock member is configured to restrict movement of the sleeve until the sleeve overcomes a predetermined torque value, with the interlock member formed integrally with a portion of the housing.
A connector includes an outer housing defining a lumen, a first male coupler mateable with a needle-free valve and positioned at a first end of the outer housing, a second male coupler positioned at a second end of the outer housing, a valve system to control fluid flow through the lumen, and an actuator movable within the outer housing between a first position and a second position. A pinch clamp of the connector operates to selectively deflect locking fingers of the actuator from a locked position to a movement position to selectively enable or prevent movement of the actuator from the first position to the second position. The actuator, based on its positioning in the first or second position, causes the valve system to be in a closed state or an open state and blocks or allows the first coupler to couple with the needle-free valve.
A61M 39/28 - Moyens de serrage pour l'écrasement des tubes flexibles, p. ex. brides de serrage à rouleaux
F16L 37/35 - Accouplements du type à action rapide avec moyens pour couper l'écoulement du fluide avec un obturateur dans chaque extrémité de tuyau avec deux clapets dont l'un au moins est ouvert automatiquement au moment de l'accouplement au moins un des clapets possédant un canal axial communiquant avec des ouvertures latérales
48.
AUTOMATED ORDERS AND RESULT REPORTING FOR PRESCRIPTION-BASED USER-ADMINISTERED DIAGNOSTIC TESTING
Systems and methods for integration of user-administered diagnostic test results with electronic health records are provided. In one aspect, a method includes receiving a prescription specifying a user-administered test and a patient, transmitting prescription information to a pharmacy and to the test provider, generating a unique order identifier which is sent to a user application that associates the order identifier with a test result after the user administers the test, receiving the test result in association with the order identifier, storing the test result and the order identifier in a medical record database in association with a medical record number or a consultation identifier, and sending a notification of the test result to the prescribing clinician.
G16H 80/00 - TIC spécialement adaptées pour faciliter la communication entre les professionnels de la santé ou les patients, p. ex. pour le diagnostic collaboratif, la thérapie collaborative ou la surveillance collaborative de l’état de santé
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
49.
SOLVENT SYSTEM FOR CO-DISSOLUTION OF THERMOPLASTIC POLYURETHANE AND ACTIVE PHARMACEUTICAL INGREDIENTS
A solvent system co-dissolves thermoplastic polyurethane and an active pharmaceutical ingredient (API) to form a dip-coating solution. The solvent system provides increased solubility of the API compared to prior art solvent systems which use tetrahydrofuran (THF) as the main solvent. A particularly useful API is chlorhexidine to provide antimicrobial properties. The solvent system includes methanol and 1,3-dioxolane in a ratio of about 10 vol.% to 40 vol.% of methanol in the 1,3-dioxolane. The dip-coating solution may be used to coat medical devices, such as catheters, with a polyurethane coating configured to release an API, such as chlorhexidine. The solvent system can dissolve greater than 55 mg/mL chlorhexidine.
A61L 29/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
Provided herein is an instrument delivery device for targeted delivery of a thrombolytic agent into an IV catheter. The instrument delivery device includes a collapsible sleeve and a catheter tube positioned within the collapsible sleeve. Proximal and distal connectors are positioned at the proximal and distal ends of the collapsible sleeve. An advancement member is positioned at the distal end of the collapsible sleeve, between the distal connector and the collapsible sleeve. The advancement member includes a housing, a wheel member on the housing and actuatable by a user, and a roller mechanism operably connected to the wheel member, with the catheter tube routed through the roller mechanism and engaged therewith. Rotation of the wheel member distally advances the catheter tube from a first position to a second position, in which the distal end of the catheter tube is disposed at or adjacent a distal end of the IV catheter.
A pressure threshold detector for a medical injector includes a first member, a second member moveable relative to the first member between a retracted position and an extended position, an inlet passageway configured to be in fluid communication with a fluid line, a cantilever arm having a cam surface, and a protrusion having a first cam profile and a second cam profile. The cam surface of the cantilever arm is engaged with the first cam profile of the protrusion when the second member is in the retracted position, and the cam surface of the cantilever arm is engaged with the second cam profile of the protrusion when the second member is in the extended position. The second member is moveable from the retracted position to the extended position when a pressure within the inlet passageway exceeds a predetermined pressure.
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
55.
AUTOREGULATION SYSTEM AND METHOD USING TISSUE OXIMETRY AND BLOOD PRESSURE
A method and apparatus for monitoring a subject's autoregulation function state is provided. The method includes: a) continuously sensing a tissue region of the subject with a tissue oximeter, the sensing producing first signals, and determining frequency domain tissue oxygen parameter values; b) continuously measuring a blood pressure level of the subject using a blood pressure sensing device, the measuring producing second signals, and determining frequency domain blood pressure values; c) determining a coherence value indicative of the subject's autoregulation state in each of a plurality of different frequency bands; and d) determining a peak coherence value indicative of the subject's autoregulation state based on the determined coherence value from each of the plurality of different frequency bands.
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
A drug delivery investigation device includes a needle insertion mechanism having a cannula, a flow path having an inlet configured to be in fluid communication with a fluid source and an outlet, connection tubing extending between the outlet of the flow path and the needle insertion mechanism, with the connection tubing in fluid communication with the cannula and the flow path, a flow sensor positioned between the inlet and the outlet of the flow path, and a pressure sensor positioned between the inlet and the outlet of the flow path.
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
57.
Stopper for a Syringe Having Anti-Sticking Features
A stopper for a syringe including a body having a tail adapted for attachment to a plunger of the syringe, and a head, the head having a outer surface that is convex, such that the outer surface is curved with an apex of the curvature extending away from a plane orthogonal to the longitudinal axis of the stopper and comprising an outer perimeter of the outer surface and the apex of the outer surface of the head is higher than the outer perimeter of the outer surface when the stopper is viewed from a side in a direction perpendicular to the longitudinal axis of the stopper. The stopper may optionally include a plurality of protrusions extending from an outer surface of the head. Also, a syringe including such a stopper.
A medical device may include a body and a photosensitizer integrated with the body. The medical device may passively resist colonization of bacteria under ambient light. The medical device may also actively resist colonization of bacteria by releasing reactive oxidative species (ROS) in response to administration of a light dose in a range of 0.5 J/cm2 to 320 J/cm2, for a duration between 1 second and 1 hour. The body may be formed by a base resin. The photosensitizer may be compounded with the base resin. The photosensitizer may be imbibed into the base resin. The medical device may include a coating disposed on a surface of the body. The photosensitizer may be disposed within the coating. The medical device may include a catheter adapter and a catheter extending distally from the catheter adapter. The catheter may be co-extruded with the photosensitizer and another material.
An instrument delivery device to insert an instrument (44) through a catheter assembly (48) may include a housing, a connector (42) coupled to the housing, a slider configured to move along a slot of the housing, and an instrument (44) disposed within the housing and coupled to the slider. The instrument may be configured to advance beyond the connector in response to movement of the slider along the slot from a proximal position to a distal position. The connector may include a curved portion 66 configured to change a direction of the instrument when the instrument is advanced through the connector.
A satellite module having at least one of a seal and an anti-premature rotation feature is provided for adjustable placement in the pump housing of a fluid delivery pump. The satellite module can have at least two separate pieces; that is, a piece with a seal and another piece with an anti-premature rotation feature. The satellite module can be a unitary member with a seal and an anti-premature rotation feature. A biasing component or a rigid component can be provided on the satellite module or pump housing to adjust distance from a fluid outlet hole in a sleeve and adjust compression on the seal.
An instrument delivery device to insert an instrument through a catheter assembly may include a housing, a connector coupled to the housing, a slider configured to move along a slot of the housing, and an instrument disposed within the housing and coupled to the slider. The instrument may be configured to advance beyond the connector in response to movement of the slider along the slot from a proximal position to a distal position. The connector may include a curved portion configured to change a direction of the instrument when the instrument is advanced through the connector. A catheter system may include a catheter adapter, which may include a side port. An annular valve may be disposed within the lumen and configured to seal the side port. The catheter system may include an instrument advancement feature configured to direct the instrument in a distal direction within the lumen of the catheter adapter.
A stopper for a syringe including a body having a tail adapted for attachment to a plunger of the syringe, a head, and, optionally, a plurality of annular ribs and grooves around the circumference of the outer sidewall of the body, where the ribs are separated by the grooves. The stopper includes a plurality of protrusions extending from an outer surface of the tail and/or the head and/or a plurality of protrusions extending outwardly from the outer sidewall from within at least one groove. The protrusions extending from an outer surface of the tail and/or the head are arranged in at least one circle, and an angular distance between two adjacent protrusions in the circle is less than the angular distance occupied by one of the protrusions. Also, a syringe including such a stopper.
A drug delivery device includes a housing, a needle having a retracted position and an extended position, a needle actuator body received within the housing and configured to move from a pre-use position where the needle is in the retracted position, to a use position where the needle is in the extended position, and to a post-use position where the needle is in the retracted position, a container received within the housing, the container configured to hold a dose of medicament, a drive assembly configured to move a dose of medicament from the container to the needle, and an alarm indicator received within the housing. The needle actuator body actuating the alarm indicator when the needle actuator body is in the post-use position.
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
64.
Phase-Correction Of Radiofrequency-Multiplexed Signals
Aspects of the present disclosure include methods for characterizing particles of a sample in a flow stream. Methods according to certain embodiments include generating frequency-encoded fluorescence data from a particle of a sample in a flow stream; and calculating phase-corrected spatial data of the particle by performing a transform of the frequency-encoded fluorescence data with a phase correction component. In certain embodiments, methods include generating an image of the particle in the flow stream based on the phase-corrected spatial data. Systems having a processor with memory operably coupled to the processor having instructions stored thereon, which when executed by the processor, cause the processor to calculate phase-corrected spatial data from frequency-encoded fluorescence data of a particle a flow stream are also described. Integrated circuit devices (e.g., field programmable gate arrays) having programming for practicing the subject methods are also provided.
G01N 15/149 - Techniques de recherche optique, p. ex. cytométrie en flux spécialement adaptées au tri des particules, p. ex. selon leur taille ou leurs propriétés
65.
SYSTEM AND METHOD FOR COMPENSATING FOR ARTERIAL PRESSURE SENSOR POSITIONING
The present disclosure relates generally to systems and methods for compensating for arterial pressure sensor positioning. Various system configurations can be used to calibrate a pressure transducer to automatically account for pressure attributable to the vertical distance between the phlebostatic axis and the pressure transducer. Various system configurations can be used to detect a vertical distance between the phlebostatic axis and a pressure transducer and to adjust pressure readings accordingly. Various system configurations can be used to position a pressure transducer at the phlebostatic axis.
A hemoshield device for reducing hemolysis in a catheter system may include a distal end, which may include a distal connector. The distal connector may include a tapered male luer configured to insert into a proximal end of a catheter hub to form a tight fluid seal. The hemoshield device may include a proximal end, which may include an adapter configured to receive a blood collection device. The adapter may include a non-patient cannula configured to pierce the blood collection device. The hemoshield device may include an extension tube. A distal end of the extension tube may be fixed within the tapered male luer, and a proximal end of the extension tube may be fixed within the adapter. The extension tube may include a fluid pathway extending from the distal connector to the adapter.
A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
A61B 5/153 - Dispositifs de prélèvement d'échantillons de sang spécialement adaptés pour le prélèvement d'échantillons de sang veineux ou artériel, p. ex. par des seringues
A61B 5/154 - Dispositifs de prélèvement d'échantillons de sang spécialement adaptés pour le prélèvement d'échantillons de sang veineux ou artériel, p. ex. par des seringues utilisant des moyens préalablement mis sous vide
A system, method, and computer program product for tracking real-time syringe volume may: obtain a plurality of images of a syringe including a fiducial marker, the fiducial marker encapsulating syringe data associated with the syringe; determine, based on the fiducial marker in at least one image, an initial volume associated with the syringe; for each image of the syringe of the plurality of images of the syringe: determine, based on the fiducial marker in that image, a region of interest in that image; and subtract, from the region of interest in that image, the region of interest of a previous image of the plurality of images to generate a subtracted image; determine, based on the subtracted image generated from a current image, a volume of a fluid dispensed from and/or remaining in the syringe; and provide the volume of the fluid dispensed from and/or remaining in the syringe.
A medication injection method where a medication injection pen comprises a dose set knob rotatable with respect to a housing to set a desired injection dose. The dose set knob comprises at least one internal thread. A leadscrew includes a thread element for advancing in a first direction via a corresponding thread engagement. A driver is rotationally fixed to the leadscrew and is rotatable in a first direction to rotate and advance the leadscrew in the first direction. The setback member is rotationally fixed to the driver. The dose stop member is rotationally coupled to the setback member and is axially movable relative to the dose set knob when the dose set knob is rotated relative to the setback member. Axial movement of the dose stop member limits the user from setting a dose that is greater than an injectable volume of medication remaining in a cartridge.
A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
A61M 5/24 - Seringues à ampoules, c.-à-d. seringues à aiguille utilisables avec des ampoules ou des cartouches échangeables, p. ex. automatiques
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
A61M 5/34 - Structures pour le raccordement de l'aiguille
A catheter assembly may include a catheter, catheter adapter, needle, needle guard, and housing. The housing may be coupled to the needle guard and disposed within a lumen of the catheter adapter. The needle guard may include first and second resilient arms, which may include first and second curved portions, respectively. When the needle is in a ready position, the first and second curved portions may be urged by a shaft of the needle into retaining contact with an inner wall of the catheter adapter. When the needle is in the retracted position, the shaft may no longer bias the first and second resilient arms outwardly such that the retaining contact between the first and second curved portions and the catheter adapter is released, and the housing and the needle guard enclose a distal tip of the needle.
A61M 25/06 - Aiguilles avec un guide pour piquer le corps ou analogues
A61M 5/162 - Raccords à aiguilles, c.-à-d. raccordements par perforation entre le réservoir et le tube
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Educational and training services relating to healthcare; medical training and teaching; training services in the field of medical disorders and their treatment; providing continuing medical education courses; advice relating to medical educational and training services. Health care services; providing medical information; providing an interactive website for sharing medical information and communication regarding medical and health care issues; providing medical information through on line chat rooms and electronic bulletin boards; providing information to physicians, health care professionals and patients on the topic of medical issues, health issues, and health awareness.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Business assistance, management and administrative services for hospitals and medical laboratories; information and advisory services in relation to the aforesaid. Educational and training services relating to healthcare; medical training and teaching; training services in the field of medical disorders and their treatment; providing continuing medical education courses; advice relating to medical educational and training services.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Business assistance, management and administrative services for hospitals and medical laboratories; provision of organizational and operational business assistance to hospitals and medical laboratories; information and advisory services in relation to the aforesaid. Design and development of computer software; hosting services, software as a service [SAAS] services, and rental of software; information and advisory services in relation to the aforesaid.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational and training services relating to healthcare; medical training and teaching; training services in the field of medical disorders and their treatment; providing continuing medical education courses; advice relating to medical educational and training services.
A closure for protectively sealing a biological fluid collection device is disclosed. The closure includes a cap and an adapter or connector. The closure of the present disclosure allows for connection to multiple different blood collection devices. In a first configuration, with the cap connected to the adapter, the closure may be connected to a first blood collection device. In a second configuration, with the cap disconnected from the adapter, the closure may be connected to a second blood collection device. An advantage of the closure of the present disclosure is that it enables a single closure device to accommodate a variety of connection options. In one embodiment, the closure includes a barrier in communication with a portion of the cap, and the barrier protectively shields a portion of the stopper and/or protectively shields a portion of the cap.
A catheter system may include a needleless connector, which may include a distal end, a proximal end, and a valve disposed between the distal end of the needleless connector and the proximal end of the needleless connector. The catheter system may include a vent assembly, which may include a proximal component and a distal component. The proximal component may include a male luer adapter, which may include a male luer. The distal component may include a distal end coupled to the proximal end of the needleless connector, and a proximal end coupled to the male luer adapter. In response to movement of the proximal component from a proximal position to a distal position with respect to the distal component, the male luer of the male luer adapter may open the valve to vent air inside the catheter system.
A sample collection accessory device configured for attachment to an open end of a collection container includes a cover and a collector. The cover includes an inner portion configured for insertion into the collection container having a sidewall having an inner surface defining a channel through the accessory device and an outer surface with an outer diameter sized to seal against an inner surface of a sidewall of the container. The cover also includes an outer portion extending radially outward from the inner portion configured to extend over an end of the sidewall of the collection container. The collector extends distally from the cover and is configured for directing a biological sample to the channel defined by the inner surface of the inner portion of the cover. A method for automated blood sample processing using a collection container and an accessory device is also provided.
An extension set may include a tube, which may include a distal end, a proximal end, and an outer surface. The extension set may include a distal connector coupled to the distal end of the tube and/or a proximal connector coupled to the proximal end of the tube. The extension set may include a patency instrument disposed within the tube. The extension set may include a translation handle coupled to the outer surface of the tube. The translation handle may be configured to move along the outer surface of the tube between a proximal position and a distal position to translate the distal end of the patency instrument between a retracted position and an advanced position. In response to the distal end of the patency instrument being in the advanced position, the distal end of the patency instrument may extend beyond the distal end of the tube.
A catheter system may include a catheter assembly, which may include a catheter hub and a catheter extending distally from the catheter hub. The catheter system may include a fluid chamber proximal to the catheter. The catheter system may include a fluid pathway within the catheter system and extending through the catheter and the fluid chamber. The catheter system may include a pressure transducer in fluid communication with the fluid chamber to monitor hemodynamic properties of a patient.
A reusable auto-injector is provided including a syringe housing configured to receive a pre-filled syringe and an injector body connected to the syringe housing and pivotable between a closed position and an open position. The injector body includes a slider housing and a slider assembly positioned within the slider housing and movable axially relative thereto between first and second positions. The slider assembly includes a guide pin with a spring positioned thereon that is actuatable between an extended state and a compressed state. The spring is in the extended state with the slider assembly in the first position and is in the compressed state with the slider assembly in the second position. A pair of connecting rods pivotably connect the syringe housing to the injector body and interact with the slider assembly to actuate the spring to the compressed state upon pivoting of the injector body to the open position.
A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
81.
Vascular Access Device With Effective Needle Length Adjustment
Vascular access devices which have needle-length adjustment features for penetrating a vial of a stopper with the full needle length and for penetrating the skin of a patient with a desired needle length, which is less than the full needle length.
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
A61M 5/46 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour commander la profondeur de pénétration
82.
AUTOMATED SAMPLE PREPARATION SYSTEM FOR DIAGNOSTIC TESTING OF SAME
An automated pre-analytical processing method and an apparatus for pre-analytical processing of samples to be forwarded to an adjacent analyzer for analysis. Rack label information is read and communicated to a processor. From the rack label information, the processor determines where to route the rack. The pre-analytical system has a rack robot that conveys racks to discrete locations depending upon the routing information assigned to the rack by the processor. The pre-analytical system has an automated station that reads the labels of individual sample containers in the rack that are brought to the automated station on instructions from the processor. Depending on the type of sample container and the type of sample disposed therein, the samples are either prepared for analysis by the automated station or the sample containers are directly passed through the automated station. Prepared samples and passed through samples are passed individually to a batching rack.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
83.
Vascular Access Device With Effective Needle Length Adjustment
Vascular access devices which have needle-length adjustment features for penetrating a vial of a stopper with the full needle length and for penetrating the skin of a patient with a desired needle length, which is less than the full needle length.
A61M 5/46 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour commander la profondeur de pénétration
A device set designed for PCNL surgery includes a puncture needle, a guidewire, a dilator, a balloon catheter, a sheath, and a drainage catheter which are all placed in a single package. A tip length of the dilator is substantially the same as a tip length of the balloon catheter. The device set may include a puncture needle, a guidewire, a plurality of dilators having different sizes, a sheath, and a drainage catheter, which are all placed in a single package, wherein all the dilators have substantially the same tip length.
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
hydrodynamic theoretical needleneedle_innerneedle_inner is an inner diameter of the sidewall of the cannula. The length-to-diameter ratio is between 7.00x1011and 9.40x1012m-3.
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
Ported catheters can be configured to facilitate insertion of a blood draw device or other vascular probe or instrument. A ported catheter may include a bushing, or wedge, that is shaped to provide a smooth entry and advancement of a tube of a blood draw device that is coupled to the ported catheter, whether via a proximal opening or a port of the ported catheter. Such a bushing may be particularly beneficial when the port of the ported catheter is oriented at an angle towards the catheter. By incorporating such a bushing, a ported catheter may be better able to minimize the occurrence of kinking or bending of the tube of the blood draw device. A ported catheter may also include a catheter strain relief feature to minimize the occurrence of kinking or bending of the tube of the blood draw device while it is extended through the catheter.
A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
A61B 5/153 - Dispositifs de prélèvement d'échantillons de sang spécialement adaptés pour le prélèvement d'échantillons de sang veineux ou artériel, p. ex. par des seringues
Dyes, including tandem dyes, are provided. Aspects of embodiments of the dyes include a fluorophore and a water-solubilizing poly-sarcosine group. Also provided are methods of using the dyes, as well as kits that include such dyes.
A disinfection and flushing device for an intravenous patient connector requires only a single coupling of a disinfection cap of the device to the patient connector, both to scrub the patient connector and to administer flushing solution through the connector via a flush syringe that is already coupled to a housing portion of the device. The disinfection cap and housing portions of the device are coupled together during the initial patient connector scrub and flush operation. Thereafter, in some embodiments, the housing and its attached, spent flush syringe, are selectively separable from the disinfection cap portion of the device, so that the disinfection cap remains in place on the patient connector. In other embodiments, the entire device, including its cap, housing and the flush syringe that is coupled to the housing, are removed from the patient connector.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 39/16 - Raccords ou accouplements pour tubes avec des dispositions pour la désinfection ou la stérilisation
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 39/00 - Tubes, raccords ou accouplements pour tubes, soupapes, voies d'accès ou similaires, spécialement adaptés pour un usage médical
A secondary securement device for a vascular access device having tubing includes a base including a first end, a second end positioned opposite the first end, a first side, a second side positioned opposite the first side, a top surface, and a bottom surface positioned opposite the top surface, with the bottom surface configured to be in contact with a patient's skin surface, and a plurality of pegs connected to the base and extending from the top surface of the base. Adjacent pegs of the plurality of pegs are configured to secure the tubing of the vascular access device.
A system, method, and computer program product may process, with a first machine learning model, at least one image to detect a plurality of medical devices therein and to provide a prediction of a device class associated with each medical device detected; identify, based on the prediction of the device class associated with each medical device, one or more medical devices for further classification; and for each medical device identified for further classification: select, based on the prediction of the device class associated with that medical device, a second machine learning model associated with the device class; process, with the selected second machine learning model, a region of interest in the at least one image including that medical device to generate a prediction of a device subclass associated with that medical device; and provide the device class and the device subclass associated with that medical device.
A needle hub for a drug delivery device includes a hub body, an activation button, a needle holder moveable relative to the hub body, a needle attached to the needle holder, a needle spring biasing the needle holder to a retracted position where the needle is positioned within the hub body, a cannula holder moveable relative to the hub body and the needle holder, a cannula attached to the cannula holder, with the cannula configured to be in fluid communication with a fluid source, and a cannula spring biasing the cannula holder to a retracted position. Movement of a portion of the hub body is configured to disengage a connection between the cannula holder and the hub body to allow the cannula holder to return to the retracted position.
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A mixing syringe system includes a barrel assembly, a constituent material reservoir, and a connector housing. The barrel assembly includes a first barrel and a second barrel and defines a first fluid flow path and a second fluid flow path, wherein a portion of the first fluid flow path is within the second fluid flow path. The constituent material reservoir defines a first reservoir flow path and a second reservoir flow path offset from the first reservoir flow path. The connector housing couples the barrel assembly to the constituent material reservoir. The connector housing defines a first connector flow path and a second connector flow path. The first connector flow path fluidically couples the first fluid flow path to the first reservoir flow path, and the second connector flow path fluidically couples the second fluid flow path to the second reservoir flow path.
A system, method, and computer program product for tracking real-time syringe volume may obtain at least two images of a syringe including a fiducial marker, the at least two images including an initial image and a current image, and the fiducial marker encapsulating syringe data; for each image of the syringe: determine, based on the fiducial marker in that image, a region of interest in that image; and segment, based on a color threshold for that image, the region of interest in that image to generate a masked image; determine, based on a pixel-to-volume mapping associated with the syringe, the masked image generated from the initial image, and the masked image generated from the current image, a volume of a fluid dispensed from and/or remaining in the syringe; and provide the volume of a fluid dispensed from and/or remaining in the syringe.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Downloadable software in the fields of medicine, health, pharmaceuticals, medical devices and medical laboratory diagnostic instruments; downloadable software for analyzing health, medical, and pharmaceutical data and medical device and medical diagnostic instrument data; electronic control devices, apparatus and hardware for storing and dispensing pharmaceuticals, and parts and fittings therefor Medical devices; medical diagnostic equipment, and parts and fittings therefor Platform as a service in the fields of medicine, health, pharmaceuticals, medical devices and medical laboratory diagnostic instruments; software as a service in the fields of medicine, health, pharmaceuticals, medical devices and medical laboratory diagnostic instruments; platform as a service for analysing health, medical, and pharmaceutical data and medical device and medical diagnostic instrument data; software as a service for analysing health, medical, and pharmaceutical data and medical device and medical diagnostic instrument data
96.
CATHETER SYSTEM FOR ARTERIAL BLOOD DRAW AND RELATED METHODS
An arterial catheter system may include a catheter assembly, which may include a catheter hub and an arterial catheter. The arterial catheter system may include a needle assembly, which may include a needle hub and an introducer needle. The arterial catheter system may include an extension tube coupled to the catheter assembly and a fluid pathway extending through the arterial catheter, catheter hub, and the extension tube. A first fluidic resistance within a portion of the fluid pathway within the extension tube may be greater than a second fluidic resistance within the fluid pathway distal to or proximal to the portion of the fluid pathway. The extension tube may have a length L and an inner diameter D. A geometric factor Gf of the portion of the fluid pathway may equal L/D4 and may be selected to reduce hemolysis during blood draw from an artery.
A vascular probe insertion assembly may include a slotted cannula having a sharpened tip configured to be inserted into a patient's vascular anatomy and a sidewall extending proximally from the sharpened tip, the sidewall defining a slot. The vascular probe insertion assembly may include a splitable sheath shaped to encircle at least part of the sidewall and a digital probe comprising a sensor tip configured to generate sensor data indicative of operation of the vascular anatomy and a shaft extending proximally of the sensor tip. The vascular probe insertion assembly may include a data hub operatively coupled to the digital probe. The data hub may be configured to receive the sensor data and convey the sensor data to a monitoring system.
Provided herein is an instrument delivery device for use with an intravenous catheter assembly. The instrument delivery device includes a housing having a proximal end portion and a distal end portion, with the housing including a first housing portion and a second housing portion arranged side-by-side and coupled together to define an inner volume. The instrument delivery device also includes an instrument movably received within the inner volume, a coupling device positioned at the distal end portion of the housing and configured to couple the housing to an access connector of an intravenous catheter assembly, and an advancement member configured to move relative to the housing to advance a distal end of the instrument beyond the distal end portion of the housing and into the intravenous catheter assembly. The housing comprises a visualization aid configured to improve visibility of the instrument within the inner volume of the housing.
A system having a processor obtain a digital hemodynamic data from a hemodynamic sensor, obtain one or more vital sign parameters characterizing vital sign data from the digital hemodynamic data, derive differential parameters based on the one or more vital sign parameters, generate combinatorial parameters using the one or more vital sign parameters and the differential parameters, determine a risk score corresponding to a probability of a future hypotension event for the living subject based on a weighted combination of a plurality of hypotension profiling parameters including the one or more vital sign parameters characterizing vital sign data, the differential parameters and the combinatorial parameters, and invoke a sensory alarm if the risk score satisfies a predetermined risk criterion.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
100.
ARTERIAL HEMOSHIELD DEVICE FOR ARTERIAL BLOOD DRAW AND RELATED METHODS
An arterial catheter system may include a catheter assembly, which may include a catheter adapter. The arterial catheter system may include an arterial catheter extending from a distal end of the catheter adapter. The arterial catheter system may include a needle assembly, which may include a needle hub and an introducer needle. The arterial catheter system may include an arterial hemoshield device coupled to the catheter assembly. The arterial catheter system may include a fluid pathway within the arterial catheter, the catheter adapter, and the arterial hemoshield device. A first fluidic resistance within a portion of the fluid pathway within the arterial hemoshield device may be greater than a second fluidic resistance within the fluid pathway distal to the portion of the fluid pathway.
A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
A61B 5/153 - Dispositifs de prélèvement d'échantillons de sang spécialement adaptés pour le prélèvement d'échantillons de sang veineux ou artériel, p. ex. par des seringues
