The present invention relates to a method for preparing an aqueous solution or dispersion comprising peracetic acid, comprising the steps of adding a peroxygen donor and an acetyl donor to an aqueous solution or dispersion to prepare an aqueous solution or dispersion comprising the peroxygen donor and the acetyl donor, which generate peracetic acid and hydrogen peroxide over the course of time, and adding an organic acid to the aqueous solution or dispersion 10 min or later, such as 15 min or later after the preparation of the aqueous solution or dispersion comprising the peroxygen donor and the acetyl donor to buffer the pH of the aqueous solution or dispersion. The aqueous solution or dispersion obtained according to the method is suitable for use in an antimicrobial intervention to protect animals, preferably poultry, in particular chicken.
The invention relates to a wound dressing or other wound contact medium containing an acetyl donor compound, and being free from peroxide compounds which is activatable by a means of applying hydrogen peroxide. The wound dressing or other wound contact medium is suitable for use in the prevention and/or treatment of wound infection in a patient comprising applying the wound dressing or other wound contact medium to a wound of the patient, and subjecting the wound dressing or other wound contact medium to a means of applying hydrogen peroxide so that the acetyl donor compound of the wound dressing or other wound contact medium is activated by the hydrogen peroxide to produce peracetic acid.
A61L 2/18 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances liquides
A61F 13/00 - Bandages ou pansementsGarnitures absorbantes
The invention relates to a multi-layered substrate, comprising a first layer, a second layer and a third layer, wherein an acetyl donor and a peroxygen donor are entrapped between the first layer and the second layer capable of generating peracetic acid and hydrogen peroxide as biocides in the presence of moisture, and a basic salt is contained in the third layer or between the second layer and the third layer. The multi-layered substrate is suitable for face masks and provides antiviral protection, in particular a protection against SARS-CoV-2 and COVID-19.
B01D 39/16 - Autres substances filtrantes autoportantes en substance organique, p. ex. fibres synthétiques
B01D 39/18 - Autres substances filtrantes autoportantes en substance organique, p. ex. fibres synthétiques la substance étant la cellulose ou ses dérivés
A41D 13/11 - Masques de protection du visage, p. ex. pour utilisation chirurgicale ou pour utilisation en atmosphère polluée
A62B 23/02 - Filtres en vue de la protection des voies respiratoires pour appareils respiratoires
A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
The invention relates to a wound dressing or other wound contact medium containing an acetyl donor compound, and being free from peroxide compounds which is activatable by a means of applying hydrogen peroxide. The wound dressing or other wound contact medium is suitable for use in the prevention and/or treatment of wound infection in a patient comprising applying the wound dressing or other wound contact medium to a wound of the patient, and subjecting the wound dressing or other wound contact medium to a means of applying hydrogen peroxide so that the acetyl donor compound of the wound dressing or other wound contact medium is activated by the hydrogen peroxide to produce peracetic acid.
A61L 15/20 - Bandages, pansements ou garnitures absorbant les fluides physiologiques tels que l'urine, le sang, p. ex. serviettes hygiéniques, tampons contenant des matériaux organiques
A61L 15/46 - Désodorisants ou produits pour neutraliser les mauvaises odeurs, p. ex. pour inhiber la formation d'ammoniac ou la multiplication de bactéries
The invention relates to a wound dressing or other wound contact medium containing an acetyl donor compound, and being free from peroxide compounds which is activatable by a means of applying hydrogen peroxide. The wound dressing or other wound contact medium is suitable for use in the prevention and/or treatment of wound infection in a patient comprising applying the wound dressing or other wound contact medium to a wound of the patient, and subjecting the wound dressing or other wound contact medium to a means of applying hydrogen peroxide so that the acetyl donor compound of the wound dressing or other wound contact medium is activated by the hydrogen peroxide to produce peracetic acid.
A61L 15/20 - Bandages, pansements ou garnitures absorbant les fluides physiologiques tels que l'urine, le sang, p. ex. serviettes hygiéniques, tampons contenant des matériaux organiques
A61L 15/46 - Désodorisants ou produits pour neutraliser les mauvaises odeurs, p. ex. pour inhiber la formation d'ammoniac ou la multiplication de bactéries
6.
Method for manufacturing a therapeutic agent for use in the treatment of infections
A method of manufacturing a therapeutic agent for the treatment of infections includes the steps of preparing a homogeneous solution of poly(DL-lactide-co-glycolide acid), preparing a solution of a peroxygen donor, preparing a solution of an acetyl donor, adding each of the solutions to a quantity of the poly(DL-lactide-co-glycolide acid) solution to produce a resultant mixture, preparing encapsulated nano- or micro-scale particles from the resultant mixture using a microencapsulator, collecting the nano- or micro-scale particles, and subsequently subjecting the particles to a lyophilization process.
A nano- or micro-scale therapeutic agent is provided for use in the treatment of an infection of a human or animal. The agent includes micro- and/or nano-particle carriers loaded with at least one inert precursor chemical. The carriers encapsulate the precursor which after release from the carrier are activatable by the physiological milieu in situ at the site of the infection to form an antimicrobial agent. Preferably, the precursor chemical or chemicals form an oxidative biocide on release, which oxidative biocide is hydrogen peroxide. Advantageously, the precursor chemicals also include an acetyl donor that on release reacts with the hydrogen peroxide to produce a mixture of peracetic acid and hydrogen peroxide. The carrier is preferably in the form of micro- and/or nano-particles that have been manufactured using a thermally induced phase separation (TIPS) process, for example the carrier may be a biodegradable polymer such as poly(lactic-co-glycolic acid) (PLGA).
A nano- or micro-scale therapeutic agent is provided for use in the treatment of an infection of a human or animal. The agent comprises micro- and/or nano-particle carriers loaded singly or in combination with at least one inert precursor chemical. The carriers encapsulate the precursor chemical or chemicals which after release from the carrier are activatable by the physiological milieu in situ at the site of the infection to form an antimicrobial agent. Preferably, the precursor chemical or chemicals form an oxidative biocide on release, which oxidative biocide is hydrogen peroxide. Advantageously, the precursor chemicals also comprise an acetyl donor that on release reacts with the hydrogen peroxide produced by the peroxygen donor to produce a mixture of peracetic acid and hydrogen peroxide. The carrier is preferably in the form of micro- and/or nano-particles that have been manufactured using a thermally induced phase separation (TIPS) process, for example the carrier may comprise a biodegradable polymer such as poly(lactic-co-glycolic acid) (PLGA).
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A nano- or micro-scale therapeutic agent is provided for use in the treatment of an infection of a human or animal. The agent comprises micro- and/or nano-particle carriers loaded singly or in combination with at least one inert precursor chemical. The carriers encapsulate the precursor chemical or chemicals which after release from the carrier are activatable by the physiological milieu in situ at the site of the infection to form an antimicrobial agent. Preferably, the precursor chemical or chemicals form an oxidative biocide on release, which oxidative biocide is hydrogen peroxide. Advantageously, the precursor chemicals also comprise an acetyl donor that on release reacts with the hydrogen peroxide produced by the peroxygen donor to produce a mixture of peracetic acid and hydrogen peroxide. The carrier is preferably in the form of micro- and/or nano-particles that have been manufactured using a thermally induced phase separation (TIPS) process, for example the carrier may comprise a biodegradable polymer such as poly(lactic-co-glycolic acid) (PLGA).
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