A continuous flow production process for preparing organic peroxides directly from alcohols or alkanes takes very safe alcohols or alkanes as starting materials, and directly reacts to obtain designated peroxides. The production process is carried out in an integrated continuous flow reactor, and a safe starting source of alcohol or alkane is continuously added at the feed inlet of the integrated continuous flow reactor, and continuously provided with a designated peroxide at the discharge port of the integrated continuous flow reactor.
C07C 409/02 - Composés peroxy le groupe —O—O— étant lié à un atome de carbone, qui n'est pas substitué de plus par des atomes d'oxygène, et à un atome d'hydrogène, c.-à-d. hydroperoxydes
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
C07C 409/22 - Composés peroxy le groupe —O—O— étant lié à un atome de carbone, qui est substitué de plus par des atomes d'oxygène liés par des liaisons simples ayant deux groupes —O—O— liés à l'atome de carbone
C07C 409/32 - Composés peroxy le groupe —O—O— étant lié à deux groupes C=O
C07C 409/38 - Composés peroxy le groupe —O—O— étant lié à un groupe C=O et à un atome de carbone, qui n'est pas substitué de plus par des atomes d'oxygène, c.-à-d. esters de peroxyacides
2.
Online continuous flow process for the synthesis of organic peroxides using hydrogen peroxide as raw material
An online continuous flow production process for directly preparing organic peroxides by using hydrogen peroxide as a raw material. This production process uses hydrogen peroxide, catalyst, and an oxidation substrate as a raw material. Substrate will be turned to designated peroxides sequentially through oxidation and workup. This process is performed in a plug-and-produce integrated continuous flow reactor, and the raw materials are continuously fed to the reactor. So, specified peroxide can be continuously obtained at the outlet of the plug-and-produce integrated continuous flow reactor.
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
C07C 409/04 - Composés peroxy le groupe —O—O— étant lié à un atome de carbone, qui n'est pas substitué de plus par des atomes d'oxygène, et à un atome d'hydrogène, c.-à-d. hydroperoxydes l'atome de carbone étant acyclique
The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.
C07C 243/22 - Hydrazines ayant des atomes d'azote de groupes hydrazine liés à des atomes de carbone de cycles aromatiques à six chaînons
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
B01J 19/24 - Réacteurs fixes sans élément interne mobile
C07C 303/22 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides d'acides sulfoniques ou de leurs halogénures à partir d'acides sulfoniques par des réactions n'impliquant pas la formation de groupes sulfo ou halogénosulfonyle
Disclosed is a fully continuous flow production process for directly preparing an organic peroxide from an alcohol or alkane. The production process uses an alcohol or alkane, that is very safe, as a starting raw material for a direct reaction so as to obtain the specified peroxide. The production process is carried out in an integrated continuous flow reactor, the safe starting raw material, i.e. the alcohol or alkane, is continuously added at the feed inlet of the integrated continuous flow reactor, and the discharge outlet of the integrated continuous flow reactor continuously gives the specified peroxide. The production process is safe and efficient and can achieve in-situ production and has no amplification effects. Compared with traditional production processes, the production time of the inventive production process is shortened to be within 15 minutes. The product can be used while being manufactured with completely zero stock, and there is no amplification effect. The product indexes are stable and have good reproducibility.
C07C 409/38 - Composés peroxy le groupe —O—O— étant lié à un groupe C=O et à un atome de carbone, qui n'est pas substitué de plus par des atomes d'oxygène, c.-à-d. esters de peroxyacides
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
5.
ONLINE FULL CONTINUOUS FLOW PRODUCTION PROCESS FOR DIRECTLY PREPARING ORGANIC PEROXIDE WITH HYDROGEN PEROXIDE AS RAW MATERIAL
Disclosed is an online full continuous flow production process for directly preparing an organic peroxide with hydrogen peroxide as a raw material. The production process uses the hydrogen peroxide, a catalyst and an oxidation substrate as starting raw materials to obtain the specified peroxide by continuously and successively subjecting the starting raw materials to oxidation and post-processing. The production process is carried out in a plug-to-play type integrated full continuous flow reactor. Compared with traditional production processes, the production time of the inventive production process is shortened by 95% or more, and the production process has no amplification effects and achieves zero stock. The product indexes are stable and have good reproducibility.
The present invention relates to a fully continuous flow synthesis process for use with 2-methyl-1,4-naphthoquinone and an integrated continuous flow reactor for use in achieving said process; the synthesis process uses 2-methylnaphthalene, an emulsifier solution, a sodium dichromate solution and a sulfuric acid solution as raw materials, and the synthesis process is carried out in the integrated continuous flow reactor; the 2-methylnaphthalene, the emulsifier solution, the sodium dichromate solution and the sulfuric acid solution are continuously added to a feeding port of the integrated continuous flow reactor to continuously undergo a transient emulsification process and an oxidation process, and 2-methyl-1,4-naphthoquinone is continuously obtained from a discharging port of the integrated continuous flow reactor; the reaction time is equal to or less than 700 s. The process is a continuous synthesis process for use with 2-methyl-1,4-naphthoquinone which is fast, safe, efficient, versatile, and easy to produce on a large scale.
C07C 46/04 - Préparation de quinones par oxydation avec formation de structures quinoïdes d'atomes de carbone non substitués de cycles aromatiques à six chaînons
C07C 50/10 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant deux cycles
7.
RAPID CONTINUOUS-FLOW SYNTHESIS PROCESS FOR FLUOROETHYLENE CARBONATE.
The present invention relates to a rapid continuous-flow synthesis process for fluoroethylene carbonate and an integrated continuous-flow reactor to implement the process. In the continuous-flow synthesis process, raw materials to be fluorinated and fluorine gas are taken as reactants, and are subjected to the steps of mixing and dispersing, fluorination reaction and gas-liquid separation continuously and successively to obtain the fluoroethylene ethylene carbonate. The synthesis process is carried out in an integrated continuous-flow reactor, wherein the raw materials to be fluorinated and fluorine gas are continuously fed to a feed inlet of the integrated continuous-flow reactor, the fluoroethylene carbonate is continuously obtained at a discharge outlet of the integrated continuous-flow reactor, and the reaction time is equal to or less than 600 seconds. The process is a fast, safe and efficient continuous synthesis process for fluoroethylene carbonate that has high versatility and easy for large-scale production.
The present invention provides a process for continuous flow synthesis of a 4-chlorophenylhydrazine salt; the three reaction steps of diazotization, reduction, and acidolysis salt formation are organically integrated in an innovative manner; using a 4-chloroaniline acidic stock solution, a diazotization reagent, a reducing agent, and acid as starting materials, continuously performing in sequence the three reaction steps of diazotization, reduction, and acidolysis salt formation to obtain a 4-chlorophenylhydrazine salt; the synthesis process is carried out in an integrated reactor and is an integrated solution. The reaction starting materials are added continuously via the material feed inlet of the integrated reactor; the three reaction steps of diazotization, reduction, and acidolysis salt formation are performed continuously in sequence in the integrated reactor; 4-chlorophenylhydrazine salt is obtained continuously from the material outlet of the integrated reactor; the total reaction time is ≤20 minutes. In comparison with conventional production processes, the total reaction time is greatly shortened and safety is significantly improved; furthermore, neither the reaction process nor the reaction product contain any reaction by-products (such as diazoamino compounds and reduction reaction intermediates); the described continuous flow process does not require an additional purification step and produces a high-purity product having a purity of 99% or higher, while also achieving a maximum yield of 99.5% or higher.
Provided is a continuous flow synthesis process for a phenylhydrazine salt and a substituted phenylhydrazine salt. Three reactions, namely diazotization, reduction, and acid hydrolysis for salt formation, are organically integrated, an aniline or substituted aniline acid solution, a diazotized reagent, a reducing agent, and an acid serve as raw materials, a salt of a phenylhydrazine derivative is produced by means of the three reactions performed continually in turn of diazotization, reduction, and acid hydrolysis for salt formation. The synthesis process is performed in an integrated reactor and is an integrated solution. The reaction raw materials are continuously added through a material inlet of the integrated reactor, the reactions of diazotization, reduction, and acid hydrolysis for salt formation are performed continually in turn in the integrated reactor, and the salt of the phenylhydrazine derivative is produced continuously at a material outlet of the integrated reactor, the total reaction time being < 20 min. Compared with a conventional production process, the total reaction time is greatly reduced, the degree of safety is significantly increased, also, both the reaction process and the reaction product comprise no reaction by-product (such as a diazoamino compound or a reduction reaction intermediate), the continuous flow process comprises no additional purification step and produces high-purity products with a purity of 99% or more.
brevets
