An implantable cranial medical device includes a housing configured to be positioned on a skull of a subject such that at least a portion of the housing covers a burr hole of the skull. The medical device also includes a brain catheter connector extending from the housing and configured to extend within the skull. The brain catheter connector includes a first connector and a second connector. The second connector extends farther away from the housing than the first connector. Additionally, the medical device includes a first fluid path extending through the housing and the first connector, and a second fluid path extending through the housing and the second connector. The first and second fluid paths are not in fluid communication with one another within the housing.
An implantable device includes a housing having a bottom configured to face the skull and a top configured to face a scalp when implanted. The device includes a first catheter connector configured to couple to a first dual lumen catheter. The first connector extends from the housing. The device comprises a second catheter connector configured to couple to a single lumen catheter. The second catheter connector extends from the housing. The device includes an opening defined by the top of the housing. The opening is configured to be accessed by a needle percutaneously inserted through the scalp when the device is implanted. The device includes a first fluid pathway from the first catheter connector to the opening defined by the top of the housing, and the device includes a second fluid pathway from the first catheter connector to the second catheter connector.
A burr hole device is configured to receive a catheter and a cable of a sheath. The sheath is configured to receive a portion of the catheter and has an electrode. When the catheter and sheath are implanted with the burr hole device, the catheter and electrode of the sheath are implanted in a brain. Systems and apparatuses may include the burr hole device and/or a cranial port device, the catheter, and the sheath.
A device is configured to receive a catheter. The catheter may be a catheter of a ventriculoperitoneal shunt or an external ventricular drain. The device includes (ii) an upper flange having an opening, and (ii) elongate body defining a lumen in communication with the opening. The catheter may be inserted through the opening and the lumen. The device includes an electrode disposed on the elongate body. When the device is implanted in a subject, the upper flange rests on a skull of the subject adjacent to a burr hole, the elongate body is inserted through the burr hole, and the electrode is positioned intracranially in the subject.
A61B 5/293 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électroencéphalographie [EEG] invasives
A61B 5/37 - Modalités, c. à d. méthodes diagnostiques spécifiques Électroencéphalographie [EEG] Électroencéphalographie intracrânienne [EEG IC], p.ex. électrocorticographie [ECoG]
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 5/03 - Mesure de la pression des fluides à l'intérieur du corps autre que la pression du sang, p.ex. de la pression cérébrale
A61M 27/00 - Appareillage pour drainage des blessures
A61M 25/04 - Dispositifs de maintien en position, p.ex. sur le corps à l'intérieur du corps, p.ex. expansibles
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
5.
DEVELOPMENT AND IMPLEMENTATION OF PSYCHOLOGICAL STATE MODEL
A method receives continuous EEG data for a long duration of time from at least one electrode intracranially implanted in a subject. The method determines a current or predicted brain state from the EEG data using an artificial intelligence (AI) model.
A device or system for delivering fluid to or removing fluid from a CSF-containing space of a brain and for recording electrical activity from white or grey matter in the brain includes a catheter including a proximal end, a distal end portion, a first lumen extending from the proximal end to the distal end portion, and one or more electrodes positioned relative to the catheter a distance from a distal end of the catheter, such that the one or more electrodes would be placed in contact with white or grey matter of the brain if the distal end of the catheter were positioned in the CSF-containing space. The catheter may include the electrodes or a lead adjacent the catheter may include the electrodes.
A method receives EEG data from at least one electrode implanted in the brain of the subject. The method determines a current or predicted brain state from the EEG data using an artificial intelligence (AI) model.
An implantable cranial medical device (100) includes a first fluid flow path, a second fluid flow path, and upper flange portion (110), and a lower portion (120). The upper flange portion (110) is configured to rest on a skull of a subject about a burr hole. The lower portion (120) is configured to be placed within the burr hole. The first fluid flow path may extend from a first opening (150) in the upper flange portion (110) to a first opening (132) in the lower portion (120). The second fluid flow path may extend from a second opening (140) in the upper flange portion (110) to a second opening (134) in the lower portion (120).
A61B 10/00 - Autres méthodes ou instruments pour le diagnostic, p.ex. pour le diagnostic de vaccination; Détermination du sexe; Détermination de la période d'ovulation; Instruments pour gratter la gorge
A system includes a first port (100) comprising a first inlet (150), a first outlet (132), and a first fluid pathway extending between them, a second inlet (140), a second outlet (134), and a second fluid pathway extending between them. The system further includes at least one CSF catheter having a first and a second lumen. The CSF catheter is coupled with the first port (100) such that the first lumen is in fluid communication with the first fluid pathway and the second lumen with the second fluid pathway. At least a first distal opening of the first lumen is placed in the CSF-containing space. The system further includes a second port (500) having a third inlet, a third outlet and a third fluid pathway extending between them. The system also includes a port catheter (600) configured to operatively couple the third fluid pathway to the second fluid pathway.
A61B 10/00 - Autres méthodes ou instruments pour le diagnostic, p.ex. pour le diagnostic de vaccination; Détermination du sexe; Détermination de la période d'ovulation; Instruments pour gratter la gorge
10.
MEDICAL DEVICE HAVING NON-FILTERED CSF WITHDRAWAL PATHWAY
An implantable medical device (100) for delivering therapeutic fluid to, and withdrawing cerebrospinal fluid (CSF) from, a CSF-containing space, includes a first inlet (116) configured to be accessed by a needle of an aspiration device; a first outlet (126); a first fluid pathway (192) extending from the first inlet (116) to the first outlet (126); a second inlet (118); a second outlet (128); and a second fluid pathway (194) extending from the second inlet (118) to the second outlet (128). The first fluid pathway (192) is free of a filter configured to prevent passage of a microbe.
A61B 10/00 - Autres méthodes ou instruments pour le diagnostic, p.ex. pour le diagnostic de vaccination; Détermination du sexe; Détermination de la période d'ovulation; Instruments pour gratter la gorge
11.
High concentration medicant solutions for treating neurological disorders
Highly concentrated solutions are disclosed along with methods of inhibiting and/or ameliorating functional neurological disorders of the brain. The method may include administering directly to a brain of a subject a medicament multiple times over a time period of at least two days. The medicament may include a half-life of less than 2 hour in the cerebrospinal fluid. The method may include inhibiting and/or ameliorating a functional neurological disorder of the brain using the medicant.
Highly concentrated solutions are disclosed along with methods of inhibiting and/or ameliorating functional neurological disorders of the brain. The method may include administering directly to a brain of a subject a medicament multiple times over a time period of at least two days. The medicament may include a half-life of less than 2 hour in the cerebrospinal fluid. The method may include inhibiting and/or ameliorating a functional neurological disorder of the brain using the medicant.
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