Abrégé

The present invention is, in part, directed to tolperisone analogs (e.g., compounds of formula (I), (I-a), (I-b), (II), (Il-a), (III), (Ill-a), (ΙΙΙ-b), (III-c), (IV), (IV-a), (V), or (V-a)) and methods of use thereof for the treatment of various conditions including elevated muscle tone and tension (e.g., spasticity, muscle spasm). In one aspect, the tolperisone analogs disclosed herein have an additional substituent at the α-position, which blocks the generation of a β- elimination product.

Classes IPC  ?

• A61K 31/12 - Cétones
• A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
• A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
• A61K 31/4453 - Pipéridines non condensées, p. ex. pipérocaïne substituées uniquement en position 1, p. ex. propipocaïne, dipérodone

Abrégé

Described herein are compositions comprising activators of TRP and ASIC channels that may be useful to improve or preserve exercise performance and exercise recovery.

Classes IPC  ?

• A61K 36/54 - Lauraceae (famille du laurier), p. ex. cannelle ou sassafras
• A61K 36/67 - Piperaceae (famille du poivrier), p. ex. poivre de Jamaïque, ou kwa-kwa
• A61K 36/906 - Zingiberaceae (famille du gingembre)
• A61P 21/02 - Relaxants musculaires, p. ex. pour la tétanie ou les crampes

Abrégé

The invention relates to methods and compositions comprising a TRP channel or ASIC channel activator for preventing or treating a disease, disorder, or condition described herein.

Classes IPC  ?

• A61K 31/05 - Phénols
• A61K 31/085 - Éthers ou acétals ayant une liaison éther à un carbone cyclique d'un noyau aromatique
• A61K 31/12 - Cétones
• A61K 31/121 - Cétones acycliques
• A61K 36/906 - Zingiberaceae (famille du gingembre)
• A61K 36/9068 - Zingiber, p. ex. gingembre
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux

Abrégé

The invention relates to methods and compositions for treating muscle cramps, muscle spasms, muscle spasticity, dystonias, and fasciculations.

Classes IPC  ?

• A61K 36/906 - Zingiberaceae (famille du gingembre)
• A61K 36/26 - Aristolochiaceae (famille de l'aristoloche clématite), p. ex. aristoloche
• A61K 36/268 - Asarum (cabaret sauvage)

Abrégé

The present invention relates to compositions of capsaicinoids, capsinoids, or related analogs or combinations thereof, and methods of preparation, formulation, and the medical use of these compositions. In one aspect, the present invention features a composition formulated for oral administration, said composition comprising an effective amount of a capsaicinoid, capsinoid, or related analog or combination thereof.

Classes IPC  ?

• A61K 31/165 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide

Abrégé

The present invention relates to compositions of ion channel activators and methods of preparation, formulation, and the medical use of these compositions. In one aspect, the present invention features a composition formulated for oral administration, said composition comprising an effective amount of an ion channel activator (e.g., a TRPV1 channel activator, a TRPA1 channel activator, an ASIC channel activator, or combination thereof).

Classes IPC  ?

• A61K 31/165 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide