The Trustees of the University of Pennsylvania (USA)
Fondazione IRCCS Istituto Nazionale dei Tumori (Italie)
Inventeur(s)
Powell, Jr., Daniel J.
Figini, Mariangela
Canevari, Silvana
Abrégé
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and CD27 costimulatory domain to treat ovarian cancer. In an embodiment, the FRα binding domain is fully human, thereby preventing a host immune response.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Figini, Mariangela
Canevari, Silvana
Abrégé
New antibodies are described having high specificity to the a-folate receptor, being of medical interest in the therapy of tumours and of other discases involving an increased expression of the a-folate receptor. All the antibodies of the present invention share the same six specific CDR in the VH and VL regions, herein defined by SEQ. ID. Nos: 1-6, responsible for the α-folate receptor specificity. In one embodiment, a subgroup of these antibodies identified as A-type is further characterized by an extended duration of binding to the a-folate receptor and, in an additional embodiment, another subgroup involving some aminoacidic modifications and identified as B-type is also characterized by an increased compatibility for human therapy.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
3.
A PROTECTIVE DEVICE FOR MONORENAL SUBJECTS OR SUBJECTS WITH RENAL DISEASE
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
POLITECNICO DI MILANO (Italie)
Inventeur(s)
Spreafico, Filippo
Rodriguez Matas, José Félix
Abrégé
There is described a protective device (1) for monorenal subjects or subjects with renal disease, comprising : - a garment (2) wearable by a subject (P) at least at a lumbar region (L) of the subject (P), - at least one protective element (4) installed on said garment (2) at a portion thereof configured to be positioned at the lumbar region (L) of the subject (P) when the garment (2) is worn by the subject (P), - a belt element (6) configured to at least partially encircle the torso of the subject (P) in the lumbar region (L) and to exert a compressive action of the at least one protective element (4) against the lumbar region (L) of the subject (P).
A41D 13/05 - Vêtements protecteurs de travail ou de sport, p. ex. blouses de chirurgien ou vêtements protégeant des coups ou des chocs protégeant uniquement une partie particulière du corps
A41D 13/12 - Blouses de chirurgien ou vêtements pour malades
A41D 13/015 - Vêtements protecteurs de travail ou de sport, p. ex. blouses de chirurgien ou vêtements protégeant des coups ou des chocs avec des moyens absorbeurs de chocs
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Vitellaro, Marco
Boeri, Mattia
Signoroni, Stefano
Abrégé
The present invention concerns the field of cancer and methods for early detection of cancerous lesions. Specifically, the invention relates to a method for early detection of cancerous lesions through the analysis of microsatellite instability in the genome of an individual from a liquid biopsy.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Milione, Massimo
Abrégé
The present invention concerns the field of oncology, and in particular tumor diagnosis for specific and tailored therapy. In particular the invention describes a method for diagnosing a tumor in a subject, said method comprising the step of performing an in vitro immunohistochemical (IHC) analysis, wherein said IHC is carried out on a fresh frozen sample and with a specific set of antibodies. The present invention further relates to a kit for IHC analysis comprising the specific panel of antibodies and instructions for use in the method of according to the invention. In a further aspect, the invention relates to the use of a kit for providing a tumor diagnosis, wherein said tumor is chosen from the group consisting of breast, liver, testis, prostate, skin (melanoma), lung, thyroid, colon, colorectal, uterus, lymph node, bladder, pancreas, spleen, upper aerodigestive tract and stomach.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
6.
DIET PREPARATION FOR THE NUTRITION OF CANCER PATIENTS WITH A RESTRICTED CALORIE INTAKE
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Rivoltini, Licia
Vernieri, Claudio
De Braud, Filippo Guglielmo
Abrégé
Daily food preparation for use as a therapeutic adjuvant in the diet of patients suffering from neoplasia, including A) a nutritional combination that contains between 6% and 56% Kcal as carbohydrates, from 7% to 20% Kcal as proteins, from 30% to 86% Kcal as lipids; and B) dietary fiber in an amount between 1 and 30 g, the daily food preparation being characterized by an average caloric content between 199 and 630 Kcal, in which the nutritional combination (A) and the dietary fiber (B) consist of foods of vegetable origin. A further object of the present invention is a kit comprising daily food preparations in accordance with the invention for use as a therapeutic adjuvant in the daily diet of patients suffering from neoplasia.
Fondazione IRCCS Istituto Nazionale dei Tumori (Italie)
Inventeur(s)
Tognoli, Emiliano
Abrégé
Method for the control of hypnotic and analgesic concentrations of an anaesthetic composition comprising the steps of: —supplying a memory unit configured to receive and record data; —supplying at least one data processing unit 101, in signal communication with the memory unit and configured to process and record data in the memory unit; —providing the bispectral index (PBIS) and the mean arterial pressure (PMAP) of a patient treated with a first anaesthetic composition comprising an initial hypnotic concentration and an initial analgesic concentration, and storing the patients PBIS and PMAP data in said memory unit; the method being characterized in that it comprises the steps of—providing a two-dimensional matrix defined, on the abscissa, by a MAP dimension relative to the variation of Mean Arterial Pressure, on the ordinate, by a BIS dimension relative to the variation of the Bispectral Index; —defining in the matrix an optimal anaesthesia zone (OAZ) located between MAP values of 65 and 110 mmHg and BIS values of 40 and 60; —localizing in the matrix the values of the PBIS and PMAP data, to define a position of the patient (B) in the matrix with respect to the optimal anaesthesia zone (OAZ); —providing an algorithm resident in said processing unit, configured to quantify the deviation of the patients position (B) with respect to the optimal anaesthesia zone (OAZ) and transforming the deviation into a quantitative variation of the initial hypnotic concentration and/or the initial analgesic concentration of the first anaesthetic composition to define a target hypnotic concentration and/or a target analgesic concentration of a second anaesthetic composition; —processing the patients PBIS and PMAP data using said algorithm to obtain the target hypnotic concentration and/or the target anaesthetic concentration of the second anaesthetic composition.
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Figini, Mariangela
Canevari, Silvana
Abrégé
HLL regions, herein defined by SEQ.ID.Nos: 1-6, responsible for the α-folate receptor specificity. In one embodiment, a subgroup of these antibodies identified as A-type is further characterized by an extended duration of binding to the α-folate receptor and, in an additional embodiment, another subgroup involving some aminoacidic modifications and identified as B-type is also characterized by an increased compatibility for human therapy.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Milione, Massimo
Abrégé
The present invention concerns the field of oncology, and in particular tumor diagnosis for specific and tailored therapy. In particular the invention describes a method for diagnosing a tumor in a subject, said method comprising the step of performing an in vitro immunohistochemical (IHC) analysis, wherein said IHC is carried out on a fresh frozen sample and with a specific set of antibodies. The present invention further relates to a kit for IHC analysis comprising the specific panel of antibodies and instructions for use in the method of according to the invention. In a further aspect, the invention relates to the use of a kit for providing a tumor diagnosis, wherein said tumor is chosen from the group consisting of breast, liver, testis, prostate, skin (melanoma), lung, thyroid, colon, colorectal, uterus, lymph node, bladder, pancreas, spleen, upper aerodigestive tract and stomach.
C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
G01N 33/532 - Production de composés immunochimiques marqués
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
10.
LOW CALORIE FOOD PREPARATION FOR THE NUTRITION OF CANCER PATIENTS
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Rivoltini, Licia
Vernieri, Claudio
De Braud, Filippo Guglielmo
Abrégé
Daily food preparation for use as a therapeutic adjuvant in the diet of patients suffering from neoplasia, including A) a nutritional combination that contains carbohydrates in an amount between 8% and 55% (w/w), proteins in an amount between 7% and 16% (w/w), lipids in an amount between 30% and 81% (w/w); and B) dietary fiber in an amount between 2 and 30 g, the food preparation being characterized by an average caloric content between 15 and 600 Kcal, in which the nutritional combination (A) and the dietary fiber (B) consist of foods of vegetable origin. A further object of the present invention is a kit comprising daily food preparations in accordance with claim 1 for use as a therapeutic adjuvant in the daily diet of patients suffering from neoplasias.
A23L 33/00 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement
A23L 33/125 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sirops d'hydrate de carboneModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sucresModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des alcools de sucreModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des hydrolysats d'amidon
A23L 33/21 - Adjonction de substances essentiellement non digestibles, p. ex. de fibres diététiques
THE TRUSTEES OF THE UNIVERITY OF PENNSYLVANIA (USA)
FONDAZIONE IRCCS ISTITUTO NAZIONATE DEI TUMORI (Italie)
Inventeur(s)
Powell, Daniel J.
Coukos, George
Figini, Mariangela
Canevari, Silvana
Abrégé
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Ciana, Paolo
Garofalo, Mariangela
Villa, Alessandro Maria
Mazzaferro, Vincenzo
Maggi, Adriana
Abrégé
Extracellular vesicles isolated from blood plasma of oncological patients for selectively delivering therapeutic or diagnostic drugs are provided. Methods for isolating extracellular vesicles from an isolated sample of blood plasma and for preparing an isolated sample of blood plasma from oncological patients are also provided.
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Rivoltini, Licia
Vernieri, Claudio
De Braud, Filippo Guglielmo
Abrégé
Daily food preparation for use as a therapeutic adjuvant in the diet of patients suffering from neoplasia, including A) a nutritional combination that contains between 6% and 56% Kcal as carbohydrates, from 7% to 20% Kcal as proteins, from 30% to 86% Kcal as lipids; and B) dietary fiber in an amount between 1 and 30 g, the daily food preparation being characterized by an average caloric content between 199 and 630 Kcal, in which the nutritional combination (A) and the dietary fiber (B) consist of foods of vegetable origin. A further object of the present invention is a kit comprising daily food preparations in accordance with the invention for use as a therapeutic adjuvant in the daily diet of patients suffering from neoplasia.
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Rivoltini, Licia
Vernieri, Claudio
De Braud, Filippo Guglielmo
Abrégé
Daily food preparation for use as a therapeutic adjuvant in the diet of patients suffering from neoplasia, including A) a nutritional combination that contains between 6% and 56% Kcal as carbohydrates, from 7% to 20% Kcal as proteins, from 30% to 86% Kcal as lipids; and B) dietary fiber in an amount between 1 and 30 g, the daily food preparation being characterized by an average caloric content between 199 and 630 Kcal, in which the nutritional combination (A) and the dietary fiber (B) consist of foods of vegetable origin. A further object of the present invention is a kit comprising daily food preparations in accordance with the invention for use as a therapeutic adjuvant in the daily diet of patients suffering from neoplasia.
Fondazione IRCCS—Istituto Nazionale dei Tumori (Italie)
Inventeur(s)
Orlandi, Rosaria
Patricola, Pietro
Segrado, Francesco
Veronese, Daniele
Elsi, Paolo
Abrégé
Described herein is a method and apparatus for storing a sample of human breath, which includes a metering device having an inlet port and a delivery port; a dispenser device in fluid communication with the delivery port of the metering device; a supply unit configured for delivering a flow of fluid through a delivery port of its own; an acquisition port configured for intake of a sample of human breath; and a selection valve. The selection valve includes a first operating condition, in which a fluid communication is obtained between the acquisition port and the inlet port of the metering device, and a second operating condition, in which a fluid communication is obtained between the delivery port of the supply unit and said metering device.
G01N 33/497 - Analyse physique de matériau biologique de matériau biologique gazeux, p. ex. de l'haleine
A61B 5/097 - Dispositifs pour faciliter la collecte du gaz respiré ou pour le diriger vers ou à travers des dispositions de mesure
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
FAMAFARM S.R.L. (Italie)
Inventeur(s)
Ferraris, Cristina
Ferri, Francesca
Armano, Maria Teresa
Abrégé
The present patent application relates to a lyophilisation process of Annatto Bixa Orellana L. powder having a tocotrienol content > 35% (w/w), comprising a pre- freezing step and a freeze-drying step, in which the Annatto powder resulting from the freeze-drying step (c) has a tocotrienol content > 39% (w/w). The invention also relates to pharmaceutical compositions comprising lyophilised Annatto powder obtained with the process of the invention and therapeutic uses of such compositions, in particular to support cancer therapy.
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
45 - Services juridiques; services de sécurité; services personnels pour individus
Produits et services
Printed matter; Book covers; Photographs [printed]; Paper stationery; Gums [adhesives] for stationery or household purposes; Teaching materials [except apparatus]; Plastic materials for packaging (not included in other classes); Printing fonts; Printing blocks; Brochures; Calendars; Electrocardiograph paper and X-ray paper; Briefcases; Catalogues; File folders; Newspapers; Instruction material of teaching (except apparatuses); Books; Manuals [handbooks]; Pencils; Forms, printed; Pamphlets; Picture postcards; Journals, Printed publications, Writing or drawing books, Magazines [periodicals], Bookmarkers, Printed matter. Hospital management; Development of hospital management systems; Advertising; Arranging events for promotional and/or advertisingpurposes. Instruction courses relating to health; Healthcare education; Training services for medical visitors; Education, providing of training, entertainment, sporting and cultural activities; Development of the mental faculties of individuals, and services to entertain or occupy the attention; Presentation of cultural or educational works to the public. Scientific and technological services and scientific research for medical purposes and design relating thereto; Scientific and industrial analysis and research services; biological testing and research; Information technology services for the pharmaceutical and healthcare industries; Food sanitation consultation; Scientific, medical and pharmacological research; Providing information relating to scientific and medical research in the fields of biochemistry, biotechnology, pharmaceutical preparations and clinical testing; DNA screening for scientific research purposes; Advisory services relating to scientific research; Preparation of reports in relation to scientific consultancy. Healthcare, medical and hospital services; Medical analysis relating to the care of persons; Medical services, Health screening, Medical services, Health care in the nature of health maintenance organizations; Consultancy and information in relation to health care and pharmacy; Preparation of reports relating to health care matters, Technical consultancy services relating to medical health; Rehabilitation linked to developing and/or regaining of mental faculties, treatment aimed at stimulating attention; Nursing home services and Rehabilitation centres. Personal and social services rendered by hospitals and others to meet the needs of individuals.
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
45 - Services juridiques; services de sécurité; services personnels pour individus
Produits et services
Printed matter; Book covers; Photographs [printed]; Paper stationery; Gums [adhesives] for stationery or household purposes; Teaching materials [except apparatus]; Plastic materials for packaging (not included in other classes); Printing fonts; Printing blocks; Brochures; Calendars; Electrocardiograph paper and X-ray paper; Briefcases; Catalogues; File folders; Newspapers; Instruction material of teaching (except apparatuses); Books; Manuals [handbooks]; Pencils; Forms, printed; Pamphlets; Picture postcards; Journals, Printed publications, Writing or drawing books, Magazines [periodicals], Bookmarkers, Printed matter. Hospital management; Development of hospital management systems; Advertising; Arranging events for promotional and/or advertisingpurposes. Instruction courses relating to health; Healthcare education; Training services for medical visitors; Education, providing of training, entertainment, sporting and cultural activities; Development of the mental faculties of individuals, and services to entertain or occupy the attention; Presentation of cultural or educational works to the public. Scientific and technological services and scientific research for medical purposes and design relating thereto; Scientific and industrial analysis and research services; biological testing and research; Information technology services for the pharmaceutical and healthcare industries; Food sanitation consultation; Scientific, medical and pharmacological research; Providing information relating to scientific and medical research in the fields of biochemistry, biotechnology, pharmaceutical preparations and clinical testing; DNA screening for scientific research purposes; Advisory services relating to scientific research; Preparation of reports in relation to scientific consultancy. Healthcare, medical and hospital services; Medical analysis relating to the care of persons; Medical services, Health screening, Medical services, Health care in the nature of health maintenance organizations; Consultancy and information in relation to health care and pharmacy; Preparation of reports relating to health care matters, Technical consultancy services relating to medical health; Rehabilitation linked to developing and/or regaining of mental faculties, treatment aimed at stimulating attention; Nursing home services and Rehabilitation centres. Personal and social services rendered by hospitals and others to meet the needs of individuals.
19.
VECTORIAL CALCULATION APPLIED TO A DECISION-MAKING MATRIX FOR THE TITRATION OF THE ANAESTHESIA LEVELS
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Tognoli, Emiliano
Abrégé
BISMAPBISMAPBISMAPBISMAPMAP data using said algorithm to obtain the target hypnotic concentration and/or the target anaesthetic concentration of the second anaesthetic composition.
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
20.
Magnetic nanoparticles for use in the treatment of tumors
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
UNIVERSITA DEGLI STUDI DI GENOVA (Italie)
CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
Inventeur(s)
Barthel, Markus
Cassani, Marco
Figini, Mariangela
Granja, Juan
Pellegrino, Teresa
Quarta, Alessandra
Abrégé
The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated The invention also relates to the pharmaceutical compositions having such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
A61K 47/52 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé inorganique, p. ex. un ion inorganique complexé avec l’ingrédient actif
The Trustees of the University of Pennsylvania (USA)
Fondazione IRCCS Istituto Nazionale Dei Tumori (Italie)
Inventeur(s)
Powell, Jr., Daniel J.
Figini, Mariangela
Canevari, Silvana
Abrégé
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and CD27 costimulatory domain to treat ovarian cancer. In an embodiment, the FRα binding domain is fully human, thereby preventing a host immune response.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
22.
LOW CALORIE FOOD PREPARATION FOR THE NUTRITION OF CANCER PATIENTS
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Rivoltini, Licia
Vernieri, Claudio
De Braud, Filippo Guglielmo
Abrégé
Daily food preparation for use as a therapeutic adjuvant in the diet of patients suffering from neoplasia, including A) a nutritional combination that contains carbohydrates in an amount between 8% and 55% (w/w), proteins in an amount between 7% and 16 % (w/w), lipids in an amount between 30% and 81% (w/w); and B) dietary fiber in an amount between 2 and 30 g, the food preparation being characterized by an average caloric content between 15 and 600 Kcal, in which the nutritional combination (A) and the dietary fiber (B) consist of foods of vegetable origin. A further object of the present invention is a kit comprising daily food preparations in accordance with claim 1 for use as a therapeutic adjuvant in the daily diet of patients suffering from neoplasias.
A23L 33/00 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement
A23L 33/115 - Acides gras ou leurs dérivésGraisses ou huiles
A23L 33/125 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sirops d'hydrate de carboneModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sucresModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des alcools de sucreModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des hydrolysats d'amidon
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Rivoltini, Licia
Vernieri, Claudio
De Braud, Filippo Guglielmo
Abrégé
Daily food preparation for use as a therapeutic adjuvant in the diet of patients suffering from neoplasia, including A) a nutritional combination that contains carbohydrates in an amount between 8% and 55% (w/w), proteins in an amount between 7% and 16 % (w/w), lipids in an amount between 30% and 81% (w/w); and B) dietary fiber in an amount between 2 and 30 g, the food preparation being characterized by an average caloric content between 15 and 600 Kcal, in which the nutritional combination (A) and the dietary fiber (B) consist of foods of vegetable origin. A further object of the present invention is a kit comprising daily food preparations in accordance with claim 1 for use as a therapeutic adjuvant in the daily diet of patients suffering from neoplasias.
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Ciana, Paolo
Garofalo, Mariangela
Villa, Alessandro Maria
Mazzaferro, Vincenzo
Maggi, Adriana
Abrégé
This invention relates to the use of extracellular vesicles isolated from the plasma of oncological patients for selectively delivering therapeutic or diagnostic drugs.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Ciana, Paolo
Villa, Alessandro Maria
Maggi, Adriana
Garofalo, Mariangela
Mazzaferro, Vincenzo
Abrégé
This invention relates to the use of extracellular vesicles isolated from the plasma of oncological patients for selectively delivering therapeutic or diagnostic drugs.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
The Trustees of the University of Pennsylvania (USA)
Fondazione IRCCS Istituto Nazionale dei Tumori (Italie)
Inventeur(s)
Powell, Daniel J.
Coukos, George
Figini, Mariangela
Canevari, Silvana
Abrégé
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
27.
APPARATUS FOR STORING A SAMPLE OF HUMAN BREATH, AND CORRESPONDING METHOD FOR STORING A SAMPLE OF HUMAN BREATH
FONDAZIONE IRCCS - ISTITUTO NAZIONALE DEI TUMORI (Italie)
COS.MA.R. S.R.L. (Italie)
Inventeur(s)
Orlandi, Rosaria
Patricola, Pietro
Segrado, Francesco
Veronese, Daniele
Elsi, Paolo
Abrégé
Described herein is an apparatus (1; 1*; 1**; 100; 100*) for storing a sample of human breath, which comprises: a metering device (2) having an inlet port (3) and a delivery port (4); a dispenser device (5) in fluid communication with the delivery port (4) of the metering device (2); a supply unit (6) configured for delivering a flow of fluid through a delivery port (7) of its own; an acquisition port (8) configured for intake of a sample of human breath; and a selection valve (9; 9**). The selection valve (9; 9**) includes a first operating condition (9A), in which a fluid communication is obtained between the acquisition port (8) and the inlet port (3) of the metering device (2), and a second operating condition (9B; 9B**), in which a fluid communication is obtained between the delivery port (7) of the supply unit (6) and said metering device (2).
A61B 5/097 - Dispositifs pour faciliter la collecte du gaz respiré ou pour le diriger vers ou à travers des dispositions de mesure
A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
G01N 33/497 - Analyse physique de matériau biologique de matériau biologique gazeux, p. ex. de l'haleine
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
28.
MAGNETIC NANOPARTICLES FOR USE IN THE TREATMENT OF TUMORS
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (Italie)
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
CONSIGLIO NAZIONALE DELLE RICERCHE (Italie)
UNIVERSIDADE DE SANTIAGO DE COMPOSTELA (Espagne)
UNIVERSITÀ DEGLI STUDI DI GENOVA (Italie)
Inventeur(s)
Barthel, Markus
Cassani, Marco
Figini, Mariangela
Granja, Juan
Pellegrino, Teresa
Quarta, Alessandra
Abrégé
The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated; the invention also relates to the pharmaceutical compositions comprising such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Figini, Mariangela
Satta, Alessandro
Gianni, Alessandro Massimo
Di Nicola, Massimo
Abrégé
The present invention concerns the field of cancer immunotherapy, and in particular drugs with low toxicity which can overcome drug-resistance. The present invention concerns novel bispecific antibodies which have the capability of binding both the TRAIL tumor associated antigen and the T lymphocyte CD3. The invention further relates to compositions comprising the bispecific antibodies and a labelling agent, and to pharmaceutical compositions. The present invention also relates to the use of the bispecific antibodies in the treatment of a tumor.
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Powell, Jr., Daniel J.
Abrégé
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and CD27 costimulatory domain to treat ovarian cancer. In an embodiment, the FRα binding domain is fully human, thereby preventing a host immune response.
C07K 16/22 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des facteurs de croissance
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Figini, Mariangela
Satta, Alessandro
Gianni, Alessandro Massimo
Di Nicola, Massimo
Abrégé
The present invention concerns the field of cancer immunotherapy, and in particular drugs with low toxicity which can overcome drug-resistance. The present invention concerns novel bispecific antibodies which have the capability of binding both the TRAIL tumor associated antigen and the T lymphocyte CD3. The invention further relates to compositions comprising the bispecific antibodies and a labelling agent, and to pharmaceutical compositions. The present invention also relates to the use of the bispecific antibodies in the treatment of a tumor.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
The Trustees of the University of Pennsylvania (USA)
Fondazione IRCCS Istituto Nazionale dei Tumori (Italie)
Inventeur(s)
Powell, Daniel J.
Coukos, George
Figini, Mariangela
Canevari, Silvana
Abrégé
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
33.
BISPECIFIC ANTIBODIES FOR USE IN CANCER IMMUNOTHERAPY
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Figini, Mariangela
Satta, Alessandro
Gianni, Alessandro Massimo
Di Nicola, Massimo
Abrégé
The present invention concerns the field of cancer immunotherapy, and in particular drugs with low toxicity which can overcome drug-resistance. The present invention concerns novel bispecific antibodies which have the capability of binding both the TRAIL tumor associated antigen and the T lymphocyte CD3. The invention further relates to compositions comprising the bispecific antibodies and a labelling agent, and to pharmaceutical compositions. The present invention also relates to the use of the bispecific antibodies in the treatment of a tumor.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
34.
COMPOUNDS BINDING TO JMJD6 WITH ANTIFIBROTIC ACTIVITY
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Colombo, Mario Paolo
Miotti, Silvia
Tagliabue, Elda
Sangaletti, Sabina
Abrégé
The present invention relates to the interaction between JMJD6 protein and collagen and to the possibility of inhibiting this interaction for the prevention and treatment of fibrosis and of tumor metastases. The invention further relates to a compound that is able to block the interaction between collagen and JMJD6 protein, in particular the invention relates to a new monoclonal antibody that recognizes JMJD6 and is able to block this interaction.
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
UNIVERSITA' DEGLI STUDI DI MILANO (Italie)
Inventeur(s)
Daidone, Maria Grazia
Appierto, Valentina
Tiberio, Paola
Dallavalle, Sabrina
Musso, Loana
Niccolini, Elisa
Abrégé
The present invention relates to a compound having formula (I) below or a pharmaceutically acceptable salt thereof: wherein: X is -COOH or NH2; R is a straight or branched C1-C10 alkylene chain; and R1 is H, straight or branched C1-C10 alkyl, aryl, or R2CO- wherein R2 is straight or branched C1-C10 alkyl, for use as antitumoral agents.
C07C 251/60 - Oximes ayant des atomes d'oxygène de groupes oxyimino liés à des atomes de carbone de radicaux hydrocarbonés substitués de radicaux hydrocarbonés substitués par des groupes carboxyle
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
36.
4-OXO-N-(4-HYDROXYPHENYL)RETINAMIDE DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Daidone, Maria Grazia
Appierto, Valentina
Tiberio, Paola
Dallavalle, Sabrina
Musso, Loana
Niccolini, Elisa
Abrégé
The present invention relates to a compound having formula (I) below or a pharmaceutically acceptable salt thereof: wherein: X is -COOH or NH2; R is a straight or branched C1-C10 alkylene chain; and R1 is H, straight or branched C1-C10 alkyl, aryl, or R2CO- wherein R2 is straight or branched C1-C10 alkyl, for use as antitumoral agents.
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
C07C 251/60 - Oximes ayant des atomes d'oxygène de groupes oxyimino liés à des atomes de carbone de radicaux hydrocarbonés substitués de radicaux hydrocarbonés substitués par des groupes carboxyle
37.
Human alpha-folate receptor chimeric antigen receptor
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Powell, Jr., Daniel J.
Abrégé
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having alpha-folate receptor (FR-alpha) binding domain and CD27 costimulatory domain to treat ovarian cancer. In an embodiment, the FR-alpha binding domain is fully human, thereby preventing a host immune response.
A01N 63/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des micro-organismes, des virus, des champignons microscopiques, des animaux ou des substances produites par, ou obtenues à partir de micro-organismes, de virus, de champignons microscopiques ou d'animaux, p. ex. enzymes ou produits de fermentation
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
C12P 21/04 - Peptides ou polypeptides cycliques ou pontés, p. ex. bacitracine
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C07K 1/00 - Procédés généraux de préparation de peptides
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
38.
METHODS FOR DIAGNOSING AND TREATING INTRAHEPATIC CHOLANGIOCARCINOMA
FONDAZIONE IRCC ISTITUTO NAZIONALE DEI TUMORI (Italie)
INSTITUTUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS (ICREA) (Espagne)
Inventeur(s)
Sia, Daniela
Mazzaferro, Vincenzo
Llovet, Josep M.
Losic, Bojan
Abrégé
Disclosed herein are methods for detecting in a biological sample from a patient the presence or absence of a fusion gene having a 5' portion from a fibroblast growth factor receptor 2 (FGFR2) gene or fragment thereof and a 3' portion from a Periphilin-1 (PPHLN1) gene or fragment thereof. The methods can further include diagnosing and treating the patient for intrahepatic cholangiocarcinoma.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Powell, Daniel J.
Coukos, George
Abrégé
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
40.
HOMO- AND HETERODIMERIC SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
CISI SCRL (Italie)
FONDAZIONE CARIPLO (Italie)
Inventeur(s)
Seneci, Pierfausto
Belvisi, Laura
Cossu, Federica
Delia, Domenico
Drago, Carmelo
Lecis, Daniele
Maiorana, Stefano
Manzoni, Leonardo, Pierpaolo
Mastrangelo, Eloise
Milani De Mayo De Mari, Mario
Perego, Paola Maria Chiara
Vasile, Francesca
Abrégé
The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
A61K 31/5517 - 1,4-Benzodiazépines, p. ex. diazépam condensées avec des cycles à cinq chaînons ayant l'azote comme hétéro-atome d'un cycle, p. ex. imidazobenzodiazépines, triazolam
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Powell, Daniel J.
Coukos, George
Figini, Mariangela
Canevari, Silvana
Abrégé
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having a-folate receptor (FRa) binding domain and 4- IBB (CD137) costimulatory domain to treat ovarian cancer.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Powell, Daniel J.
Coukos, George
Figini, Mariangela
Canevari, Silvana
Abrégé
The invention provides compositions and methods for treating ovarian cancer.Specifically, the invention relates to administering a genetically modified T cell having a-folatereceptor (FRO binding domain and 4- IBB (CD137) costimulatory domain to treat ovariancancer.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
43.
THERAPEUTIC AGENT, COMPOSITION INCLUDING SAID AGENT, IMPLANTABLE DEVICE AND PROCESS FOR THE TREATMENT OF CERVICAL CANCER AND/OR FOR THE PREVENTION OF THE FORMATION OF NEOPLASMS IN CORRESPONDENCE OF THE CERVIX IN A HUMAN FEMALE GENITAL SYSTEM.
FONDAZIONE IRCCS "ISTITUTO NAZIONALE DEI TUMORI" (Italie)
Inventeur(s)
Raspagliesi, Francesco
Abrégé
A medical composition including a chemotherapeutic medication or a targeted therapy medication is used in a human female patient for the treatment of a disease selected in the group comprising cervical cancer, cervical intraepithelial neoplasia (CIN), human papillomavirus (HPV) infection of the female genital system; the chemotherapeutic agent or targeted therapy medication is locally delivered directly to cervix of a female genital system by an implanted medical device including a stem to be implanted in the cervix. The stem has a drug carrying layer including the medical composition. A process for the treatment of the above diseases is also disclosed.
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Gianni, Alessandro Massimo
Carlo-Stella, Carmelo
Abrégé
A multi-kinase inhibitor, in particular Sorafenib, is used for the preparation of a pharmaceutical composition in the treatment of a variety o pathological conditions involving vascular hyperpermeability in order to reduce vascular hyperpermeability.
FONDAZIONE IRCCS "ISTITUTO NAZIONALE DEI TUMORI" (Italie)
Inventeur(s)
Colombatti, Marco
Fracasso, Giulio
Cingarlini, Sara
Canevari, Silvana
Figini, Mariangela
Abrégé
An isolated monoclonal antibody or fragment thereof binding prostate specific membrane antigen (PSMA) preferably in its native form on the surface of tumour cells. A conjugate of the antibody with an active ingredient and modified forms of the antigen-binding antibody fragment are also provided. The complete antibody and the antigen- recognising fragment thereof are used alone or conjugated for the treatment and the diagnosis of tumours or tissues associated to the tumour overexpressing the PSMA antigen, preferably prostatic neoplastic diseases.
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Scolastico, Carlo
Manzoni, Leonardo, Pierpaolo
Seneci, Pierfausto
Belvisi, Laura
Delia, Domenico
Bolognesi, Martino
Mastrangelo, Eloise
Milani, Mario De Mayo De Mari
Motto, Llaria
Drago, Carmelo
Abrégé
The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
A61K 31/5517 - 1,4-Benzodiazépines, p. ex. diazépam condensées avec des cycles à cinq chaînons ayant l'azote comme hétéro-atome d'un cycle, p. ex. imidazobenzodiazépines, triazolam
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (Italie)
Inventeur(s)
Baker, Joffre B.
Shak, Steven
Gianni, Luca
Abrégé
The present invention provides sets of genes the expression of which is important in the prognosis of cancer. In particular, the invention provides gene expression information useful for predicting whether cancer patients are likely to have a beneficial treatment response to chemotherapy.
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C40B 30/04 - Procédés de criblage des bibliothèques en mesurant l'aptitude spécifique à se lier à une molécule cible, p. ex. liaison anticorps-antigène, liaison récepteur-ligand
C40B 40/06 - Bibliothèques comprenant des nucléotides ou des polynucléotides ou leurs dérivés
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer