A microstructure cartridge is disclosed. The microstructure cartridge comprises: a base plate including a first plate region that is inserted into a microstructure applicator, a second plate region that is not inserted into the microstructure applicator adjacent to the first plate region, and a bending or cutting guide line forming a boundary between the first plate region and the second plate region; and microneedles located in the first plate region, wherein the second plate region is configured to be bent or separated by the guide line as a boundary.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
2.
IMPLANTABLE MICRONEEDLE AND MANUFACTURING METHOD THEREFOR
An implantable microneedle and a manufacturing method therefor is disclosed. The implantable microneedle includes a coating layer for covering at least one part of the surface of a tip part of the microneedle. When exposed to moisture, the coating layer can be separated from the tip part of the microneedle and thus be implanted.
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
B81B 1/00 - Dispositifs sans éléments mobiles ou flexibles, p. ex. dispositifs capillaires microscopiques
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
The present invention relates to a photocurable hemostatic composition and, specifically, to a photocurable liquid hemostatic composition containing a hyaluronic acid-based photocrosslinkable compound and a photoinitiator as active ingredients, and to a hemostatic agent of a film or sponge formulation freeze-dried from the composition, wherein, by increasing the degree of substitution of a photocrosslinkable functional group, the composition can quickly form a gel or a film adhesive layer within a few seconds during light radiation, and the resulting gel remains in a body more stably for a long time, thus enhancing hemostasis and tissue regeneration effects.
There are provided a photo-cross-linking copolymerized hyaluronic acid sponge and a preparation method therefor, the sponge not being sticky and not dripping, having flexibility to be usable in various parts of the body, having excellent water binding force to help tissue regeneration, having very excellent biocompatibility so as to be absorbable into the skin when attached to the body for a long time, so that the trouble of having to be removed can be decreased, and comprising, through a photo-cross-linking reaction, polymers having various lengths so as to be applicable in various forms of medical antihemorrhagic agents, wound-coating agents, adhesive barriers.
C08J 3/28 - Traitement par ondes énergétiques ou par rayonnement de particules
C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
C08L 5/08 - ChitineSulfate de chondroïtineAcide hyaluroniqueLeurs dérivés
C08J 9/28 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par élimination d'une phase liquide d'un objet ou d'une composition macromoléculaire, p. ex. par séchage du coagulum
A61L 15/42 - Utilisation de matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 15/64 - Utilisation de matériaux caractérisés par leur fonction ou leurs propriétés physiques spécialement adaptés pour être résorbables à l'intérieur du corps
5.
MICROSTRUCTURE CARTRIDGE AND MICROSTRUCTURE APPLICATOR
A microstructure cartridge is disclosed. The microstructure cartridge comprises: a base plate including a first plate region that is inserted into a microstructure applicator, a second plate region that is not inserted into the microstructure applicator adjacent to the first plate region, and a bending or cutting guide line forming a boundary between the first plate region and the second plate region; and microneedles located in the first plate region, wherein the second plate region is configured to be bent or separated by the guide line as a boundary.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
6.
MANUFACTURE OF PHOTO-CROSSLINKABLE BIODEGRADABLE TISSUE ADHESIVE USING COPOLYMER
The present invention relates to the manufacture of a photo-crosslinkable biodegradable tissue adhesive using a multinetwork-forming copolymer, and provides a hyaluronic acid copolymer compound having excellent elongation, mechanical properties, and tissue adhesion. The compound fundamentally does not undergo phase separation, and enables the manufacture of a tissue adhesive with desired adhesive characteristics and physical characteristics.
An implantable substance delivery vehicle of the present invention comprises: a pin comprising a bevel tip and an engraved groove on the surface of the bevel tip; and a substance to be delivered into the body, inserted so as so as to protrude outwardly from the tip, wherein, when the implantable substance delivery vehicle is used for implantation, the substance to be delivered into the body, inserted so as so as to protrude, is caught in tissue so as to be readily detached.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (République de Corée)
SNVIA CO., LTD. (République de Corée)
Inventeur(s)
Yang, Seung Yun
Lee, Hyeseon
Seong, Keum-Yong
Park, Samdae
Lee, Kang Oh
Abrégé
The present invention relates to a photocurable hemostatic composition and, specifically, to a photocurable liquid hemostatic composition containing a hyaluronic acid-based photocrosslinkable compound and a photoinitiator as active ingredients, and to a hemostatic agent of a film or sponge formulation freeze-dried from the composition. By increasing the degree of substitution of a photocrosslinkable functional group, the composition can quickly form a gel or a film adhesive layer within a few seconds during light radiation, and the resulting gel remains in a body more stably for a long time, thus enhancing hemostasis and tissue regeneration effects. In addition, the composition has excellent adhesiveness even in tissues wet from bleeding, and thus can be used as a more effective hemostatic agent in various tissue sites.
The present invention relates to a photo-cross-linking copolymerized hyaluronic acid sponge and a preparation method therefor, and, more specifically, to a photo-cross-linking copolymerized hyaluronic acid sponge and a preparation method therefor, the sponge not being sticky and not dripping, having flexibility to be usable in various parts of the body, having excellent water binding force to help tissue regeneration, having very excellent biocompatibility so as to be absorbable into the skin when attached to the body for a long time, so that the trouble of having to be removed can be decreased, and comprising, through a photo-cross-linking reaction, polymers having various lengths so as to be applicable in various forms of medical antihemorrhagic agents, wound-coating agents, adhesive barriers and the like.
A photocrosslinkable hydrogel may comprise a radioisotope-labeled photocrosslinkable compound or a pharmaceutically acceptable salt thereof, which may be used as a composition for radiotherapy, a composition for radiodiagnostic imaging and a composition for anticancer treatment. The hydrogel is excellent in staying in a local area requiring radiation treatment, so that it can be treated while minimizing damage to surrounding tissues. In addition, it can be used in combination with an anticancer agent and used as a pharmaceutical composition for anticancer treatment, so that cancer can be effectively treated. The hydrogel can be manufactured on site immediately and conveniently using a portable microfluidic system, thereby maximizing the radiation treatment effect.
A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
A61K 47/58 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. poly[méth]acrylate, polyacrylamide, polystyrène, polyvinylpyrrolidone, alcool polyvinylique ou résine d’acide sulfonique de polystyrène
11.
PHOTO-CROSSLINKED HYALURONIC ACID SPONGE AND MANUFACTURING METHOD THEREOF
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (République de Corée)
Inventeur(s)
Park, Sam Dae
Yang, Seung Yun
Park, Su Young
Hwang, Young Jun
Jeong, Se Min
Abrégé
The present invention relates to a photo-crosslinked hyaluronic acid sponge and to a manufacturing method thereof and, more particularly, to a photo-crosslinked hyaluronic acid sponge and a manufacturing method thereof, the sponge being capable of: being used on various parts of the body by virtue of having no stickiness and not dripping; helping tissue regeneration by virtue of having excellent moisture binding ability; being absorbed into the skin by virtue of having excellent biocompatibility when the sponge is attached to the body for a long time, thereby reducing the effort needed to remove the sponge; and being effectively utilized as a medical hemostatic agent, a wound coating agent, and an anti-adhesion agent in a porous form by virtue of the sponge comprising polymers of various lengths through a photo-crosslinking reaction.
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (République de Corée)
SNVIA CO., LTD. (République de Corée)
Inventeur(s)
Yang, Seung Yun
Park, Samdae
Lee, Hyeseon
Abrégé
The present invention relates to the manufacture of a photo-crosslinkable biodegradable tissue adhesive, and provides a novel hyaluronic acid compound having excellent elongation and excellent adhesive force even in skin and mucosal tissues, in which the physical properties of the adhesive can be adjusted by mixing HAMA with a photo-crosslinkable HA having a different photo-crosslinkable length, and thus, the adhesive can be used as a medical adhesive that can be used in various sites of a body.
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (République de Corée)
SNVIA CO., LTD. (République de Corée)
Inventeur(s)
Yang, Seung Yun
Park, Samdae
Lee, Hyeseon
Abrégé
The present invention relates to the manufacture of a photo-crosslinkable biodegradable tissue adhesive using a copolymer, and provides a hyaluronic acid copolymer compound having excellent elongation, mechanical properties, and tissue adhesion. The compound fundamentally does not undergo phase separation, and enables the manufacture of a tissue adhesive with desired adhesive characteristics and physical characteristics.
The present invention relates to a composition for deodorizing a thiol compound and, more particularly, provides a composition for deodorizing a thiol compound comprising sodium hyaluronate salt as an active ingredient. The sodium hyaluronic salt reduces hydrogen sulfide generated from the thiol compound so as to solve the odor problem of the thiol compound, thereby enhancing the usability of the thiol compound, and a functional cosmetic composition comprising the composition of the present invention and glutathione solves the problem of an unpleasant odor generated from a sulfur component of glutathione, and can be effectively utilized for whitening and anti-aging by using the advantages of glutathione.
The present invention relates to a microneedle and, more particularly, to a microneedle that can easily be prevented from detaching when inserted into the skin by improving the shape of the microneedle applied to a patch.
A61F 13/00 - Bandages ou pansementsGarnitures absorbantes
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour la suture des plaiesSupports ou emballages pour aiguilles ou matériaux de suture
B29C 39/02 - Moulage par coulée, c.-à-d. en introduisant la matière à mouler dans un moule ou entre des surfaces enveloppantes sans pression significative de moulageAppareils à cet effet pour la fabrication d'objets de longueur définie, c.-à-d. d'objets séparés
The present invention provides an implantable microneedle and a manufacturing method therefor. An implantable microneedle according to the present invention comprises a coating layer for covering at least one part of the surface of a tip part of the microneedle. When exposed to moisture, the coating layer can be separated from the tip part of the microneedle and thus be implanted.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
B81B 1/00 - Dispositifs sans éléments mobiles ou flexibles, p. ex. dispositifs capillaires microscopiques
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
17.
MICRONEEDLE BAND HAVING IMPROVED ACTIVITY FOR PROMOTING GROWTH OF FINGERNAILS AND TOENAILS
The present invention pertains to a microneedle band for promoting the growth of fingernails and toenails, and more specifically, to a microneedle band for promoting the growth of fingernails and toenails, wherein a microneedle formed from hyaluronic acid and containing a drug having human growth hormone (hGH) and biological activity attaches to the surface of a fingernail root and fingernail matrix (or toenail root and toenail matrix) so that the drug having human growth hormone and biological activity slowly dissolves together with the microneedle (hyaluronic acid) and is released to the fingernail root, fingernail matrix, and skin around the fingernail (or toenail root, toenail matrix, and skin around toenail), thereby enhancing the function of fingernail stem cells and promoting the proliferation and differentiation of progenitor cells. Therefore, the microneedle band can benefit the health and growth of fingernails and toenails.
The present invention relates to a microneedle and, more specifically, to a microneedle comprising a needle part which is applicable to a patch and has a shape improved to easily prevent separation thereof when being inserted into skin. The microneedle of the present invention comprises a base part and a plurality of needle parts extending from one surface of the base part, wherein: each of the needle parts includes a head part having a conical end portion for easy insertion into skin and a body part extending from the head part to the base part; and the body part includes a groove part transversely extending along the circumference of the body part.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
The present invention relates to a method for manufacturing a hyaluronic acid film for a mask sheet and, more specifically, to a method for manufacturing a hyaluronic acid film, which can be formed with a large area and a uniform film thickness and is also easily delaminated, wherein the hyaluronic acid film contains only hyaluronic acid as a single component, so that after the hyaluronic acid film is attached to the skin, all the components permeate into the skin without the need of a subsequent removal step, and thus more nutrients can be provided to the skin.
SNVIA CO., LTD. (République populaire démocratique de Corée)
Inventeur(s)
Yang, Seung Yun
An, Beum Soo
Seong, Keum Yong
An, Sung Min
Abrégé
In a composition and a microneedle for a localized obesity treatment containing the same in accordance with the present disclosure, the composition in accordance with the present disclosure contains a gelatin, decomposes a fat in a body, and inhibits lipogenesis and fat deposition in the body.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (République de Corée)
SNVIA CO.,LTD. (République de Corée)
Inventeur(s)
Yang, Seung Yun
Lee, Seung Soo
Lee, Kang Oh
Abrégé
The present invention relates to a microneedle patch and, more specifically, to microneedles which are easily prevented from falling off when inserted into the skin, by means of enhancing the shape of the microneedles applied to a patch. Microneedles according to the present invention comprise: a patch portion; and a plurality of microneedles extending on one surface of the patch portion. The microneedles are provided in a reverse taper form in which the cross-sectional area gradually increases toward the end part. The microneedles according to the present invention can be prevented from falling off the skin. The microneedles according to the present invention can easily and selectively be broken off after the insertion into the skin. The microneedles according to the present invention are formed in a reverse taper form easily preventing the microneedles from falling off the skin, and the entire cross-sectional area can be maintained to be uniform with respect to the length direction and thus the strength can be maintained.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
brevets
