Fundación para la Investigación Biomédica del Hospital Universitario La Paz (Espagne)
Fundación para la Investigación Biomédica del Hospital Universitario Ramon y Cajal (Espagne)
Inventeur(s)
De Miguel Gonzalez, Maria De La Paz
Arnalich Montiel, Francisco
Moratilla Riofrio, Adrian
Cadenas Martin, Marta
Abrégé
Procedure for obtaining an artificial corneal construct by 3D printing. The procedure comprises the following stages: i. providing a composition in the form of bioink comprising type I collagen or a mixture of type I, type V and/or type VI collagen at a concentration between 0.2 and 80 mg/ml, at a pH between 3.4 and 9 and where the composition optionally comprises proteoglycans of corneal origin selected from the group consisting of chondroitin sulfate, dermatan sulfate and keratan sulfate or any combination thereof at a concentration between 1 and 10 g/ml; ii. printing between 2 and 25 successive layers of the composition comprising the bioink from the previous stage by means of 3D printing, wherein the 3D printing is characterized by presenting an accumulated height of between 400 and 6000 μm and a variation in height per layer of at least ten times the thickness per layer of the desired artificial corneal construct, wherein the variation in height per layer is understood as the distance at which one layer is produced over the previous layer; and producing each layer to obtain collagen fibrils having a direction with an angle of 70° to 110° with respect to the direction of the collagen fibrils of the previous layer, keeping the bioink at a temperature that does not gel; iii. induce collagen gelation by incubating the layered product obtained from stage ii at 30-40° C.; and iv, induce the hardening, compaction and/or controlled dehydration of the layered product obtained from stage iii by incubating the layered product at a temperature of 20-40° C. and a humidity of 10 to 90% until the succession of layers comprises a size between 40 and 600 μm, with a thickness per layer between 20 and 25 μm thick.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Science and technology services; Research services; all the aforesaid services, in relation to the following fields: The study of primary and secondary immunodeficiencies and immunocompromised diseases. Human healthcare services; Telemedicine services.
11.
PORTABLE DISINFECTION SYSTEM BASED ON INDUCTION HEATING
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA - FJD (Espagne)
Inventeur(s)
Sarnago Andía, Héctor
Lucía Gil, Óscar
Acero Acero, Jesús
Burdío Pinilla, José Miguel
Gómez Barrena, Enrique
Cordero, Enrique
Rico, Alicia
Pozo, José Juan
Esteban Moreno, Jaime
Abrégé
Portable induction heating system for eliminating biofilms and microorganisms through localized hyperthermia of the metallic elements of prostheses or implants, suitable for its medical use in operating rooms, comprising an induction coil, a DC-AC power electronic stage connected to the induction coil and a DC power supply stage connected to the DC-AC power electronic stage; and where these three elements are housed inside a sealable insulation housing comprising a sterilizable, electrically insulating, thermally conductive material. The DC-AC power electronic stage comprises, furthermore, a wide-bandgap semiconductor bridge-type power stage that allows for a highly compact and efficient design that also provides a very high efficiency dissipating heat. As a result, the system of the invention can be completely sealed and, thus, easily sterilized without requiring the use of air or liquid cooling means.
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO DE LA PAZ (Espagne)
Inventeur(s)
García Rivera, Francisco Julián
García Rivera, Mª Carmen
Carballo Carrillo, Mª Angeles
Jiménez Yuste, Víctor
García Arias-Salgado, Elena
Álvarez Román, María Teresa
Butta Coll, Nora Viviana
Abrégé
The invention relates to a device for the preservation of biological tissue samples using a preserving liquid from a tank, without the personnel handling the sample being exposed to said liquid, comprising: a container with an internal space in which the sample is accommodated, an upper zone and a lower zone, an upper cover including an inlet opening that communicates with the internal space and a lower cover including an outlet opening that communicates with the internal space, wherein the device also comprises two non-return valves located in the inlet and outlet openings, and a flexible bellows-type wall that encloses the internal space and extends from the upper zone to the lower zone of the container, which can be extended via an action of a user, allowing liquid to enter into the internal space.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Scientific research and laboratory apparatus, educational apparatus and simulators. Medical apparatus and instruments. Science and technology services. Medical services.
17.
ARTIFICIAL CONSTRUCTS FOR USE IN OPHTHALMOLOGY, METHODS FOR OBTAINING THE SAME, AND THEIR USE
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO RAMÓN Y CAJAL (Espagne)
Inventeur(s)
De Miguel González, María De La Paz
Arnalich Montiel, Francisco
Moratilla Riofrío, Adrián
Cadenas Martín, Marta
Abrégé
Procedure for obtaining an artificial corneal construct by 3D printing. The procedure comprises the following stages: i. providing a composition in the form of bioink comprising type I collagen or a mixture of type I, type V and/or type VI collagen at a concentration between 0.2 and 80 mg/ml, at a pH between 3.4 and 9 and where the composition optionally comprises proteoglycans of corneal origin selected from the group consisting of chondroitin sulfate, dermatan sulfate and keratan sulfate or any combination thereof at a concentration between 1 and 10 µg/ml; ii. printing between 2 and 25 successive layers of the composition comprising the bioink from the previous stage by means of 3D printing, wherein the 3D printing is characterized by presenting an accumulated height of between 400 and 6000 µm and a variation in height per layer of at least ten times the thickness per layer of the desired artificial corneal construct, wherein the variation in height per layer is understood as the distance at which one layer is produced over the previous layer; and producing each layer to obtain collagen fibrils having a direction with an angle of 70º to 110º with respect to the direction of the collagen fibrils of the previous layer, keeping the bioink at a temperature that does not gel; iii. induce collagen gelation by incubating the layered product obtained from stage ii at 30-40 ºC; and iv, induce the hardening, compaction and/or controlled dehydration of the layered product obtained from stage iii by incubating the layered product at a temperature of 20-40 ºC and a humidity of 10 to 90% until the succession of layers comprises a size between 40 and 600 µm, with a thickness per layer between 20 and 25 µm thick.
Fundación para la Investigación Biomédica del Hospital Universitario La Paz (Espagne)
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S. (Espagne)
Inventeur(s)
Cuenca, Maria Vela
Gonález Navarro, Pablo
Quiroga, Jaime Valentín
López, Adela Escudero
Cavanova, Lucía Fernández
Martínez, Antonio Pérez
Abrégé
This disclosure provides a method for treating a subject afflicted with a cancer comprising administering to the subject a combination of therapeutically effective amounts of an isolated population of natural killer (NK) cells, preferably activated and expanded NK (NKAE) cells, and an antibody or an antigen-binding portion thereof that binds specifically to C-X-C Chemokine Receptor 4 (CXCR4) expressed on the surface of a cancer cell.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
UP DEVICES AND TECHNOLOGIES, S.L. (Espagne)
Inventeur(s)
Muñoz Caro, Jesús Manuel
Ruiz-Valdepeñas Martín De Almagro, Santiago
Azabal Agudo, Alfredo
Abrégé
Device for the application of photodynamic therapy, characterized in that it comprises: a) a balloon made of a transparent elastic material with a closed front end and an open rear end, wherein the balloon is configured for being introduced into a cavity of the anogenital region of a patient; b) a transparent or translucent tubular body housed inside the elastic balloon, and such that an air chamber is defined between the elastic balloon and the tubular body; and c) a base body coupled to the elastic balloon and to the tubular body to keep them attached to one another. The device is also characterized in that the base body has a conduit for the passage of air into the chamber between the elastic balloon and the tubular body in order to cause the balloon to inflate.
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
Martín Mateos, Pedro
Acedo Gallardo, Pablo
Jorcano Noval, José Luis
Díaz Ojeda, Luis
Bonastre Juliá, Jorge
Martínez Méndez, José Ramón
Largo Aramburu, Carlota
Abrégé
An optical diagnostic device enabling the non-invasive monitoring of the perfusion status of skin flaps, comprising for this purpose: an optical fibre (9); three or more light sources (1), each light source (1) being configured to emit at a different wavelength in the visible range, the light sources (1) being coupled to the optical fibre (9); a collimator (3) coupled to the optical fibre (9) at an opposite end to the light sources (1), intended to illuminate the surface of a tissue of interest (2); a detector (4) associated with the collimator (3) and intended to capture a light reflected by the tissue of interest (2), said detector comprising one demodulator for each light source (1); and a control module (6) connected to the light sources (1).
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO DE LA PRINCESA (Espagne)
UNIVERSIDAD AUTONOMA DE MADRID (Espagne)
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL 12 DE OCTUBRE (Espagne)
Inventeur(s)
Egea Máiquez, Francisco Javier
Farré Alins, Victor
Palomino Antolin, Alejandra
Narros Fernandez, Paloma
Martins Rosa, Juliana
Parada Perez, Esther
Hernandez Garcia, Borja Jesús
Roda Frade, José María
Yus Teruel, Santiago
Lagares Gomez-Abascal, Alfonso
Sanchez Carabias, Cristina
Gandia Juan, Luis
Abrégé
Disclosed is a method for determining the long-term evolution of acute brain damage in individuals, which comprises determining the expression product of at least two of the biomarkers SAA1, S100β and TLR4 in a biological sample taken from an individual, and establishing the statistical significance of the concentration of the expression product of the biomarker. Also disclosed is the use of a device for determining the expression product of the biomarkers, and a pharmaceutical composition for use in the treatment of acute brain damage.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
Cuenca, María Vela
Gonzalez-Navarro, Pablo
Quiroga, Jaime Valentín
López, Adela Escudero
Casanova, Lucía Fernández
Martínez, Antonio Pérez
Abrégé
This disclosure provides a method for treating a subject afflicted with a cancer comprising administering to the subject a combination of therapeutically effective amounts of an isolated population of natural killer (NK) cells, preferably activated and expanded NK (NKAE) cells, and an antibody or an antigen-binding portion thereof that binds specifically to C-X-C Chemokine Receptor 4 (CXCR4) expressed on the surface of a cancer cell.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
09 - Appareils et instruments scientifiques et électriques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Scientific research and laboratory apparatus, educational apparatus and simulators; Information technology and audio-visual, multimedia and photographic devices. Human healthcare services.
29.
IN VITRO METHOD FOR DIAGNOSING ASTHMA OR SUBFORMS THEREOF
FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA FUNDACIÓN JIMÉNEZ DÍAZ (Espagne)
CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED (CIBER) (Espagne)
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
FUNDACIÓN CONCHITA RÁBAGO DE JIMÉNEZ DÍAZ (Espagne)
Inventeur(s)
Del Pozo Abejón, Victoria
Sastre Dominguez, Joaquín
Rodrigo-Muñoz, José Manuel
Sastre Turrión, Beatriz
Quirce Gancedo, Santiago
Cañas Mañas, José Antonio
Abrégé
The present invention shows that miR-185-5p exhibits higher levels of relative expression (2-ΔCt, where ΔCt= Ct miRNA of interest (miR-185-5p) -Ct endogenous miRNA) in asthma patients than in healthy individuals. Moreover, the levels of expression of miR-185-5p differ not only between healthy individuals and asthma patients, but also between healthy individuals and each of the subgroups of asthma patients (intermittent, persistent mild, moderate and severe). The results further show that the last two severity levels, the persistent moderate and severe levels, exhibit a gradation or progressive increase in expression in comparison with intermittent and persistent mild levels.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Advertising, marketing and promotional services. Education, entertainment and sport services. Science and technology services.
34.
PROGNOSTIC METHOD FOR DETERMINING THE RISK OF RELAPSE IN RENAL CANCER PATIENTS WITH A CLEAR CELL TYPE OF RENAL CARCINOMA, STAGES I AND II, AND KIT FOR SAME
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMEDICA DEL HOSPITAL 12 DE OCTUBRE (Espagne)
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
Miranda Utrera, Natalia
Villacampa Aubá, Felipe
Castellano, Daniel
Fresno Vara, Juan Ángel
Gámez Pozo, Angelo
Abrégé
A prognostic method, and a kit, for determining the risk of relapse of renal cancer of the clear cell renal carcinoma type, stages I and II, in a human subject; comprised of: (a) determining, in a tumor sample (biopsy) from the human subject, the levels of expression of the microRNAs hsa-miR-223, hsa-miR-103, hsa-miR-107, hsa-miR-425, hsa-miR- 340, hsa-miR-130b, hsa-miR-652, hsa-miR-214, and hsa-miR-204; (b) determining a value which depends on the levels of expression of the microRNAs; and (c) determining the risk of relapse in renal cancer of the clear cell renal carcinoma type, in stages I and II, in the said human subject, by comparing the value obtained in step (b) with a cut-off value.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
35.
DETERMINATION OF METHYLATION AND MIRNA-7 LEVELS FOR PREDICTING THE RESPONSE TO A PLATINUM-BASED ANTITUMOR COMPOUND
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO DE LA PAZ (Espagne)
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (Espagne)
UNIVERSIDAD AUTÓNOMA DE MADRID (Espagne)
INSTITUTO DE INVESTIGACIÓN SANITARIA FUNDACIÓN JIMÉNEZ DÍAZ (Espagne)
Inventeur(s)
Ibáñez De Cáceres, Inmaculada
Pernía Arias, Olga
De Castro Carpeño, Javier
Perona Abellón, Rosario
Rojo Todo, Federico
Vera Puente, Olga
Jiménez Hernández, Julia
Abrégé
The invention relates to a method for determining the response to an antitumour compound comprising platinum in a patient with ovarian cancer, said method comprising (i) determining the level of methylation in the CpG island of sequence SEQ ID NO:1, and (ii) comparing the level of methylation in said CpG island in the gene encoding miR-7 or the expression level of miR-7 with a corresponding reference value, in which an increase in the methylation level obtained in (i) or a decrease in the expression level obtained in (i) with respect to the corresponding reference value indicates that the patient's ovarian cancer is resistant to said platinum compound. The invention also relates to the use of miR-7 or a precursor thereof for the production of a drug for the treatment of a patient with a cancer that is resistant to a platinum-based antitumour compound.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
INSTITUTO DE INVESTIGACIÓN SANITARIA - FUNDACIÓN JIMÉNEZ DÍAZ (Espagne)
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ. (Espagne)
Inventeur(s)
Ortiz Arduan, Alberto
Sanchez Niño, María Dolores
Abrégé
The invention relates to a composition comprising the RNA identified by sequences SEQ ID NO: 1-3, and the use thereof for producing a medication for treating chronic kidney disease. The invention also relates to a method for selecting, from a compound library, compounds that can be used in the treatment of chronic kidney disease, said selection method comprising the following steps: (a) incubating tubular kidney cells in the presence of one of the compounds selected from the compound library; (b) determining whether the expression of BASP1 in the tubular kidney cells is lower than the expression of BASP1 in a control sample; and (c) identifying the compound chosen in step (a) as a compound that can be used in the treatment of chronic kidney disease, when the expression of BASP1 in the tubular kidney cells is lower than the expression of BASP1 in a control sample.
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED EN BIOINGENIERÍA, BIOMATERIALES Y NANOMEDICINA (CIBER-BBN) (Espagne)
UNIVERSIDAD DE ZARAGOZA (Espagne)
Inventeur(s)
Martín Saavedra, Francisco Manuel
Vilaboa Díaz, Nuria Elda
Cebrián Hernando, Virginia
Arruebo Gordo, Manuel
Santamaría Ramiro, Jesús
Gómez Navascués, Leyre
Abrégé
The invention relates to a photothermal composition comprising a fibrin hydrogel matrix or a mixture of the precursors thereof, thrombin and fibrinogen, in which hydrogel plasmonic nanoparticles and heat-sensitive effectors are embedded, said effectors containing therapeutic agents that are released by applying electromagnetic radiation of a determined intensity and wavelength to the composition. The photothermal composition is suitable for generating hyperthermia in biological tissues in which said composition is implanted. The invention therefore also relates to the use of the composition for the destruction of tumours, the treatment of infections or the regeneration of tissues, as well as for the controlled administration of therapeutic agents.
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (Espagne)
UNIVERSIDAD AUTÓNOMA DE MADRID (Espagne)
FUNDACIÓN HOSPITAL DE MADRID (Espagne)
Inventeur(s)
Ibáñez De Cáceres, Inmaculada
Belda Iniesta, Cristóbal
Pernía Arias, Olga
Perona Abellón, Rosario
Cortés Sempere, María
Abrégé
The invention relates to a method for predicting the response to treatment with radiotherapy combined with chemotherapy based on cisplatin in patients suffering from cancer, preferably non-small cell lung cancer, where said method is based on the detection of the presence of methylation of the gene IGFBP-3. The invention also relates to an in vitro method for designing a personalised treatment for an individual suffering from said disease. The method of the invention can be quantitative or semi-quantitative. The invention also relates to a probe for the quantitative detection of the methylation of the gene IGFBP-3, to a kit comprising same, and to the use of said kit for predicting the response of an individual receiving the described treatment.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
43.
METHOD FOR DETERMINING THE RISK OF DEVELOPING AN INFECTIOUS DISEASE
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
EMPIREO, S. L. (Espagne)
Inventeur(s)
López Collazo, Eduardo
Abrégé
The invention relates to a method for obtaining useful data for predicting the risk of developing an infectious disease, comprising the detection and/or quantification of a mitochondrial compound in a biological sample. The invention also relates to an in vitro method for predicting said risk, and to the use of a kit for same. Preferably, the subject has suffered an acute myocardial infarction, or will undergo, or has undergone, a surgical operation.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
44.
SINGLE-PORT ACCESS DEVICE FOR LAPAROSCOPIC SURGERY
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
Zapardiel Gutiérrez, Ignacio
De Santiago García, Javier
Abrégé
The invention relates to a surgical device for operations using laparoscopic techniques, more concretely an access device which allows access to the inner areas where the operation must be carried out, by means of previous insertion of trocars in the channels of the device, such that the operation is carried out by means of a single incision in the skin and allowing the suitable handling of the required instrument. The device described consists of a soft material and has an at least partially swellable structure, thereby facilitating the access thereof to the area of the operation and allowing a better adaptation thereof to the patient by providing better adjustment and sealing.
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED EN BIOINGENIERÍA, BIOMATERIALES Y NANOMEDICINA (CIBER-BBN) (Espagne)
Inventeur(s)
Vilaboa Díaz, Nuria
Calzado Martín, Alicia
Crespo García, Lara
Saldaña Quero, Laura
Moreo Calvo, Pedro
Alastrué Vera, Víctor
Abrégé
Chamber for cell culture on biomaterials, designed especially for use in a bioreactor, which is divided into a base (1) and an upper cover (2) that complement one another and which guarantee the leaktightness of the chamber closure. In the base (1) there is a channel (2) arranged longitudinally therein and within which there are uniformly spaced wells (3) designed to accommodate culture samples (14). In the upper cover (6) there is an inlet (7) and an outlet for the fluid flowing through, such that when the chamber is closed said inlet and outlet are in communication with the channel (2) in the base (1).
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO DE LA PAZ (Espagne)
Inventeur(s)
Ramírez De Molina, Ana I.
Reglero Rada, Guillermo J.
Vargas Alonso, Teodoro
Molina Arranz, Susana
González-Vallinas Garrachón, Margarita
Feliu Batlle, Jaime
Moreno Rubio, Juan
Cejas Guerrero, Paloma
Abrégé
The invention relates to the methods for predicting the risk of relapse for patients who have colorectal cancer, and to the methods for providing said patients with personalised medicine, based on the expression levels of the genes ACSL1, ACSL4, GCNT3, LPL, APOC1 and SCD, the expression products of which are involved in cellular energy metabolism. The invention also relates to the kits for carrying out the predictive methods and the methods for providing predictive medicine.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
48.
AORTIC ENDOPROSTHESIS FOR THE TREATMENT OF AN ANEURYSM
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
Riera Del Moral, Luís Felipe
Abrégé
The invention relates to an endoprosthesis consisting of a tubular body (1) and end attachment means (2) for fixing the position of said tubular body (1). Said endoprosthesis also comprises a bag (3) which is connected to the tubular body (1) and surrounds same, defining a closed compartment (4) between the bag (3) and the tubular body (1), provided with an opening (5) through which a catheter is guided for the insertion of cells into said compartment (4) so that it expands and adapts to the sac (7) of the aneurysm.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
Zapardiel Gutierrez, Igacio
De Santiago Garcia, Javier
Abrégé
The invention relates to a laparoscopic surgical instrument comprising a base body (1) lengthened in a longitudinal direction, a handle (2) fixed to the proximal end of the base body (1), and a gripping surgical tool (3) fixed to the distal end of the base body (1). A protecting tip (4) is mounted in such a way that it can slide along an outer surface of the base body (1), between a distal protection position wherein said protecting tip (4) covers the gripping tool (3), and a proximal working position wherein the protecting tip (4) leaves the gripping tool (3) exposed. A spring (5) is configured and arranged in such a way that it is deformed and stores energy when the protecting tip (4) is moved from said distal protection position to said proximal working position, and frees said energy in order to push the protecting tip (4) back to the distal protection position.
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; Apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; Apparatus for recording, transmission or reproduction of sound or images; Magnetic data carriers, recording discs; Compact discs, DVDs and other digital recording media; Mechanisms for coin-operated apparatus; Cash registers, calculating machines, data processing equipment, computers; Computer software; Fire-extinguishing apparatus. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software.
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL (Espagne)
UNIVERSIDAD DE ALCALÁ (Espagne)
Inventeur(s)
De Miguel González, Mª Paz
Arnalich Montiel, Francisco
Royuela, María Del Mar
Abrégé
The invention relates to a corneal endothelium injector comprising a first route of entry of the graft into the injector and a second route of injection of the graft into the eye. The first route has a larger diameter than the second route so as to minimise the risk of tearing during the suction of the graft since this is carried out in the first route, in order to then inject the graft into the eye via the second route, the form of the injector progressively moulding the graft so that it comes out of the second route in a suitably rolled manner.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
52.
FUNCTIONAL HEART-HEALTHY DRINK CONTAINING WINE AND EXTRACTS OF HOPS
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (Espagne)
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO DE LA PAZ (Espagne)
Inventeur(s)
Reglero Rada, Guillermo J.
De Miguel Del Campo, Enrique
Marín Martín, Francisco
Fornari Reale, Tiziana
Prodanov Prodanov, Marin
Ruiz Rodríguez, Alejandro
Largo Aramburu, Carlota
Tabernero Urbieta, María
Ibáñez Ezequiel, Elena
Jaime De Pablo, Laura
Soler Rivas, Cristina
Rodríguez García-Risco, Mónica
Santoyo Diez, Susana
González Lorente, Monserrat
Arranz Gutiérrez, Elena
Gil Ramírez, Alicia
Abrégé
The invention relates to a functional drink containing dealcoholised wine, aroma of wine, isoxanthohumol-enriched hops extract and, optionally, grape marc extract and grape seed extract. The invention also relates to a method for obtaining the hops extract and to the use of said drink in the prevention or treatment of metabolic syndrome.
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO DE LA PAZ (Espagne)
UNIVERSIDAD AUTÓNOMA DE MADRID (Espagne)
EMPRESA PÚBLICA HOSPITAL DEL NORTE (Espagne)
Inventeur(s)
Cejas Guerrero, Paloma
Feliu Batlle, Jaime
De Castro Carpeño, Javier
Belda Iniesta, Cristóbal
Moreno García, Víctor
Burgos Lizalde, Emilio
Sánchez Hernández, José Javier
Casado Sáenz, Enrique
Abrégé
The invention relates to an in vitro method for predicting the clinical response of a patient diagnosed with colorectal cancer to an anti-tumor therapy or for identifying a patient diagnosed with colorectal cancer who is unlikely to respond to treatment with an anti-tumor therapy, preferably a neoadjuvant anti-tumor therapy; the method includes detecting the levels of expression of a genome fingerprint consisting of six genes. Likewise, the invention relates to kits for implementing said method.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
54.
DEVICE FOR ISOLATING AND IMMOBILIZING ANIMALS IN LABORATORIES
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
Glaria Enriquez, Alberto
Mañas Rueda, Ana
Velazquez Soto, Ricardo
Abrégé
Device for isolating and immobilizing animals in laboratories for radiation tests, which comprises an inner housing (10) inside an outer housing (20). The lid of the inner housing is at the top thereof, while in the outer housing it is in a side wall so that the two lids are not aligned. The inner housing (10) has first ventilation openings (14) and first holes (13) aligned with second ventilation openings (23) and second holes (22) in the outer housing (20). The inner housing (10) also has means for adhesively attaching the animal (15).
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMEDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
Castell Gómez, José Tomás
Abrégé
The present invention relates to a surgical device for interrupted suture. It integrates a hollow needle (2) suitable for perforating selectable tissues and allowing the passage there through of a biocompatible T-suture thread (3), with an anchor (4); and a cylindrical rod (7) sized to be introduced and linearly displaced through the inside of the channel of said needle to push the mentioned anchor (4), to expulse it through the distal end of the needle (2). The device further comprises driving means comprising a pusher arranged for pushing the mentioned rod (7) by its proximal end and energy retaining and releasing means associated to the mentioned pusher for applying a push force thereto and causing, at will, a quick displacement of predetermined length, for pushing the suture once that the end is in a body cavity.
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour la suture des plaiesSupports ou emballages pour aiguilles ou matériaux de suture
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMEDICAL DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
Alvarez Gallego, Mario
Abrégé
The present invention relates to a surgical device (1) for extracting surgical specimens for isolating, containing and extracting body tissue from inside the body, which reduces the volume of the surgical specimens, increasing their consistency and shaping them with an elongated shape by means of a mechanism of insuflating and subsequent fluid extraction. To that end, the surgical device (1) uses a two-layer bag (5) and additionally provides, on one hand, insuflating and suction means (8) which allow compacting the sample and shaping it to an elongated shape, and, on the other hand, adaptation means (9) which allow gradually expanding the abdominal wall to the maximum diameter of the elongated sample, at the time of extracting the sample, reducing the need of enlarging the surgical incisions and reducing the recovery time.
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO DE LA PAZ (Espagne)
Inventeur(s)
De Miguel Del Campo, Enrique
Reglero Rada, Guillermo
Largo Aramburu, Carlota
Fornari Reale, Tiziana
Rodríguez García-Risco, Mónica
Jaime De Pablo, Laura
Santoyo Diez, Susana
Señorans Rodríguez, Francisco Javier
Posadas Mañanes, Sinforiano José
García Grande, Antonio
Merino Martín, Joaquín
Caz Bonillo, Juan Víctor
Abrégé
The composition comprises a rosemary extract and vitamin E, and may be used as a nutritional supplement and also in the production of pharmaceutical compositions for reducing inflammatory processes and lipid peroxidation in general and, in particular, processes associated with the menopause, and also for preventing and/or treating the adverse effects of ionizing radiation.
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (Espagne)
CIBER-BBN (Espagne)
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
González Carrasco, José Luis
Frutos Torres, Emilio
Vilaboa Díaz, Nuria
Saldaña Quero, Laura
Abrégé
The invention relates to a process for producing a metal-coated biomaterial, by means of a metallurgic method of immersing a titanium metal substrate in a molten alloy of aluminum and silicon. The invention further relates to the use of said biomaterial in biomedical applications.
A61C 8/00 - Moyens destinés à être fixés à l'os de la mâchoire pour consolider les dents naturelles ou pour y assujettir des prothèses dentairesImplants dentairesOutils pour l'implantation
59.
SYSTEM AND METHOD FOR OBTAINING DATA ON THE BREATHING CYCLE OF A PATIENT
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO DE LA PAZ (Espagne)
Inventeur(s)
Goldman Tarlovky, Luís
Abrégé
The invention relates to a system and non-invasive method for obtaining data on the breathing cycle of a patient from a video sequence of the patient recorded by a thermographic camera, that includes the following operations: identifying the thoracic region (TX), abdominal region (AB) and at least one nasal vestibule (NS) of the patient in the thermographic video sequence; and processing the thermographic video sequence in order to infer, as a function of periodic changes in said regions, data on the breathing cycle of the patient.
A61B 5/113 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre se produisant au cours de la respiration
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; Apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; Apparatus for recording, transmission or reproduction of sound or images; Magnetic data carriers, recording discs; Automatic vending machines and mechanisms for coin-operated apparatus; Cash registers, calculating machines, data processing equipment and computers; Fire-extinguishing apparatus. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software.
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; Apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; Apparatus for recording, transmission or reproduction of sound or images; Magnetic data carriers, recording discs; Automatic vending machines and mechanisms for coin-operated apparatus; Cash registers, calculating machines, data processing equipment and computers; Fire-extinguishing apparatus. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software.
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
Espinosa, Enrique
Gámez-Pozo, Angelo
Sánchez-Navarro, Iker
Fresno Vara, Juan Ángel
Abrégé
The invention relates to the field of molecular biology and medicine. In particular, the invention relates to a method for the subclassification of tumours. Specifically, the invention relates to a method for prognosis of the evolution of tumours and, consequently, a useful method to employ when making decisions concerning the treatment to be administered to a patient. In addition, the invention relates to a kit that can be used to subclassify tumours using said method.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
63.
IDIPAZ INSTITUTO DE INVESTIGACIÓN HOSPITAL UNIVERSITARIO LA PAZ
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Paper, cardboard and goods made from these materials, not included in other classes; printed matter; bookbinding material; photographs; stationery; adhesives for stationery or household purposes; artists' materials; paint brushes; typewriters and office requisites (except furniture); instructional and teaching material (except apparatus); plastic materials for packaging (not included in other classes); printers' type; printing blocks. Education, providing of training, arranging and conducting of colloquiums, conferences, congresses, seminars, symposiums, training workshops, publication of texts, other than publicity texts, publication of books. Scientific and technological services and research and design relating thereto; bacteriological, biological, chemical research and chemical analysis.
64.
INGEMM INSTITUTO DE GENETICA MEDICA Y MOLECULAR DEL HOSPITAL UNIVERSITARIO LA PAZ
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; apparatus for recording, transmission or reproduction of sound or images; magnetic data carriers, recording discs; automatic vending machines and mechanisms for coin-operated apparatus; cash registers, calculating machines, data processing equipment and computers; fire-extinguishing apparatus. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software.
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (Espagne)
Inventeur(s)
García Fernández, Javier
Abrégé
The present invention concerns an anaesthesia machine simulator which gives mainly anaesthetists the opportunity to have a better knowledge of the elements and parameters present in a standard anaesthesia working station. In addition, this apparatus is used for reproducing the different critical situations which can occur during patient ventilation, with the purpose that anaesthetists should be capable of handling said situations in the most appropriate form for the patient.
A61M 16/01 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux spécialement conçus pour l'anesthésie
G09B 23/28 - Modèles à usage scientifique, médical ou mathématique, p. ex. dispositif en vraie grandeur pour la démonstration pour la médecine