A novel cyclic phosphazene compound that is represented by Formula (1) and is useful as a flame retardant of a resin material can enhance flame retardancy of the resin material and achieve good dielectric properties while suppressing deterioration in physical properties. In Formula (1), n is an integer of 3 to 8. R1 and R2 are (i) each independently a nitro group, either an alkyl group or an alkoxy group having 1 to 8 carbon atoms in which an alkyl group having 1 to 6 carbon atoms or an aryl group may be substituted, or an either aryl group or an aryloxy group having 6 to 20 carbon atoms in which an alkyl group having 1 to 6 carbon atoms or an aryl group may be substituted; or (ii) forming, in-between them, a saturated or an unsaturated cyclic structure that may be substituted with an alkyl group having 1 to 6 carbon atoms or a carbonyl group. a and b are each independently an integer of 0 to 4. The type of the oxaphosphorin ring-containing structure of each repeating unit is independent.
A novel cyclic phosphazene compound that is represented by Formula (1) and is useful as a flame retardant of a resin material can enhance flame retardancy of the resin material and achieve good dielectric properties while suppressing deterioration in physical properties. In Formula (1), n is an integer of 3 to 8. R1 and R2 are (i) each independently a nitro group, either an alkyl group or an alkoxy group having 1 to 8 carbon atoms in which an alkyl group having 1 to 6 carbon atoms or an aryl group may be substituted, or an either aryl group or an aryloxy group having 6 to 20 carbon atoms in which an alkyl group having 1 to 6 carbon atoms or an aryl group may be substituted; or (ii) forming, in-between them, a saturated or an unsaturated cyclic structure that may be substituted with an alkyl group having 1 to 6 carbon atoms or a carbonyl group. a and b are each independently an integer of 0 to 4. The type of the oxaphosphorin ring-containing structure of each repeating unit is independent.
C07F 9/6584 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle comportant des atomes de phosphore, avec ou sans atomes d'azote, d'oxygène, de soufre, de sélénium ou de tellure, comme hétéro-atomes du cycle comportant des atomes de phosphore et d'azote, avec ou sans atomes d'oxygène ou de soufre, comme hétéro-atomes du cycle comportant un atome de phosphore comme hétéro-atome du cycle
A population of antibodies including homogeneous antibodies in which N-linked complex sugar chains attached to asparagine (Asn) at position 297 of CH domains of Fc regions of two heavy chains on the left and the right of each antibody are sugar chains structurally different from each other is described as well as a method of producing the population of antibodies.
The present invention provides a hydrolase used in enzyme replacement therapy for a lysosomal storage disease. Provided is a hydrolase that is present in lysosomes and that, when deficient, causes a lysosomal storage disease, the hydrolase including at least one sugar chain having a biantennary sugar chain with a sialic acid at an end.
In the present invention, a novel phosphazene compound represented by formula (1), which is useful as a flame retardant for resin materials, can achieve favorable dielectric properties in addition to being able to increase flame retardancy and suppress deterioration of physical properties in resin materials. In formula (1), n is an integer between 3 and 8. R1and R2 are: (i) each independently an alkyl group or alkoxy group having 1-8 carbon atoms, which may be substituted with a nitro group, an alkyl group having 1-6 carbon atoms or an aryl group, or an aryl group or aryloxy group having 6-20 carbon atoms, which may be substituted with an alkyl group having 1-6 carbon atoms or an aryl group; or (ii) form a saturated or unsaturated cyclic structure that may be substituted with an alkyl group having 1-6 carbon atoms or a carbonyl group. a and b are each independently an integer between 0 and 4. The type of each repeating oxaphosphorin ring-containing structure is independent.
C07F 9/6581 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle comportant des atomes de phosphore, avec ou sans atomes d'azote, d'oxygène, de soufre, de sélénium ou de tellure, comme hétéro-atomes du cycle comportant des atomes de phosphore et d'azote, avec ou sans atomes d'oxygène ou de soufre, comme hétéro-atomes du cycle
Provided are: a method for producing an antibody population uniformly including antibodies having a left-right asymmetric sugar chain; and a uniform antibody population of antibodies having a left-right asymmetric sugar chain, which is obtained by said method. This method for producing an antibody population, which uniformly includes antibodies in which N-type complex sugar chains bound to asparagines (Asn) at the 297th positions in CH domains of Fc regions of two heavy chains on the left and right sides of an antibody are sugar chains having different structures, comprises: (i) a step for cleaving, by endo-β-N-acetylglucosaminidase (ENGase), sugar chains bound to two heavy chains on the left and right sides of the antibody in an antibody composition, and purifying and isolating antibodies in which sugar chains of both heavy chains are cleaved; (ii) a step for mixing a population of the antibodies in which sugar chains of both heavy chains are cleaved and which are obtained in step (i), any oxazolined sugar chain X or a sugar derivative which generates oxazoline and of which the sugar chain is a sugar chain X, and ENGase which is modified so as to suppress sugar chain cleavage activity and improve sugar chain transfer activity, to produce antibodies in which the sugar chain X is bound to only one heavy chain among two heavy chains on the left and right sides, and purifying and isolating the antibodies; and (iii) a step for mixing the antibodies in which the sugar chain X is bound to only one heavy chain among two heavy chains on the left and right sides and which are obtained in step (ii), an oxazolined sugar chain Y having a structure different from that of the sugar chain X or a sugar derivative which generates oxazoline and of which the sugar chain is a sugar chain Y, and ENGase which is modified so as to suppress sugar chain cleavage activity and improve sugar chain transfer activity, to produce antibodies in which the sugar chain Y is bound to the other heavy chain among the two heavy chains on the left and right sides and the sugar chains bound to the two heavy chains on the left and right sides are sugar chains having different structures, and purifying and isolating the antibodies.
C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
C12P 1/00 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes
C12P 21/00 - Préparation de peptides ou de protéines
6.
FLAME-RETARDANT PROCESSING OF POLYESTER-BASED SYNTHETIC FIBER STRUCTURE
The present invention provides: a flame retardant for polyester-based synthetic fiber structures which includes aminopentaphenoxycyclotriphosphazene; and a flame-retardant processing agent for polyester-based synthetic fiber structures, obtained by dispersing the flame retardant in a solvent in the presence of a surfactant.
D06M 13/44 - Traitement des fibres, fils, filés, tissus ou articles fibreux faits de ces matières, avec des composés organiques non macromoléculairesUn tel traitement combiné avec un traitement mécanique avec des composés contenant de l'azote contenant azote et phosphore
C09K 21/12 - Substances organiques contenant du phosphore
NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (Japon)
FUSHIMI PHARMACEUTICAL CO., LTD. (Japon)
Inventeur(s)
Kato, Atsushi
Ishikawa, Fumihiro
Miura, Daisuke
Abrégé
A ceramidase inhibitor which comprises a compound represented by formula (I) or a pharmaceutically acceptable salt thereof; and a ceramide synthesis promoter which comprises a compound represented by formula (II) or a pharmaceutically acceptable salt thereof. The ceramidase inhibitor and ceramide synthesis promoter according to the present invention can increase the amount of ceramide in cells or skin and, therefore, are appropriately usable for, e.g., moisturizing, reducing wrinkles, ameliorating atopic dermatitis symptoms, preventing/treating xeroderma, preventing spots, tightening flabby skin, anti-itching, suppressing melanogenesis, enhancing barrier function, activating fibroblasts and regenerating skin cells.
A61K 31/351 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle non condensés avec un autre cycle
A61K 31/366 - Lactones ayant des cycles à six chaînons, p. ex. delta-lactones
A61K 31/70 - Hydrates de carboneSucresLeurs dérivés
A61K 31/7004 - Monosaccharides ayant uniquement des atomes de carbone, d'hydrogène et d'oxygène
A61K 31/7012 - Composés ayant un groupe carboxyle libre ou estérifié, lié directement ou par une chaîne carbonée, à un atome de carbone du radical saccharide, p. ex. acide glucuronique, acide neuraminique
The present invention provides: a flame retardant for polyester-based synthetic fiber structures, comprising at least one aminophenoxy cyclotriphosphazene selected from 2,4,6-triamino-2,4,6-triphenoxy cyclotriphosphazene and 2,4-diamino-2,4,6,6-tetraphenoxy cyclotriphosphazene; and a flame-retardant processing agent for polyester-based synthetic fiber structures, which is obtained by dispersing the flame retardant in a solvent in the presence of a surfactant. The present invention further provides a flame-retardant processing method for polyester-based synthetic fiber structures, the method involving flame-retardant processing of a polyester-based synthetic fiber structure by use of the flame-retardant processing agent.
D06M 13/44 - Traitement des fibres, fils, filés, tissus ou articles fibreux faits de ces matières, avec des composés organiques non macromoléculairesUn tel traitement combiné avec un traitement mécanique avec des composés contenant de l'azote contenant azote et phosphore
C09K 21/12 - Substances organiques contenant du phosphore
TECHNOPOROUS KOREA CO., LTD. (République de Corée)
Inventeur(s)
Ito, Yoshiaki
Komoto, Taiho
Fushimi, Taishi
Toya, Tsutomu
Abrégé
Provided is a cosmetic sponge which is constituted of an elastic polyurethane object of a three-dimensional membranous structure, wherein the elastic polyurethane object has an ethanol permeation time in the range of 10-400 seconds, excluding 400 seconds, has cells so that in an area of 1.0 mm × 1.0 mm within the section thereof, there are 150 or more cells having a maximum diameter of 15-150 μm and 10 or less cells having a maximum diameter exceeding 10 μm and that the number of cells having a maximum diameter of 15-75 μm is 80% or more of the number of cells having a maximum diameter of 15-150 μm, and has an apparent density of 120-200 kg/m3. Even when the cosmetic sponge is used for applying a cosmetic preparation that is low in thixotropic property and viscosity, the cosmetic preparation is less apt to infiltrate deeply into the inner part of the sponge and is moderately absorbed thereinto, and the cosmetic preparation can be spread over a larger area. Also provided are: a process for producing the elastic polyurethane object by an aqueous coagulation method using particles of an inorganic salt that have a specific particle size distribution; and an applicator for cosmetic preparations which employs the cosmetic sponge.
A45D 34/04 - Récipients ou accessoires spécialement conçus pour l'emploi de produits de toilette ou cosmétiques liquides, p. ex. de parfums spécialement conçus pour étendre un liquide, p. ex. à l'aide d'un rouleau ou d'une bille
A45D 33/34 - Houppettes, p. ex. comportant un récipient
C08J 9/26 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par élimination d'une phase solide d'un objet ou d'une composition macromoléculaire, p. ex. par lessivage
10.
PRODUCTION METHOD FOR POROUS BODY, THREE-DIMENSIONAL MESH-LIKE POROUS BODY, LIQUID FILTER, AND LIQUID-ABSORBING SPONGE
Provided is a production method for a three-dimensional mesh-like porous body that comprises a thermoplastic elastomer, said production method including a step in which: a composition comprising the thermoplastic elastomer, inorganic salt particles that are soluble in water, and a polyhydric alcohol that is soluble in water as the main raw materials thereof is kneaded, the kneaded product is degassed and molded, the molded product obtained thereby is cured, the inorganic salt particles and the polyhydric alcohol are subsequently extracted using water, and the result is dried. The blending amount of the polyhydric alcohol in the composition is 55 mass% or more with respect to the maximum blending amount of the polyhydric alcohol that is uniformly mixed with the thermoplastic elastomer when thermally fusing the thermoplastic elastomer.
C08J 9/26 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par élimination d'une phase solide d'un objet ou d'une composition macromoléculaire, p. ex. par lessivage
B01D 39/16 - Autres substances filtrantes autoportantes en substance organique, p. ex. fibres synthétiques
11.
1,5-ANHYDRO-D-GLUCITOL-CONTAINING COLLAGEN PRODUCTION ACCELERATOR
NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (Japon)
FUSHIMI PHARMACEUTICAL CO., LTD. (Japon)
Inventeur(s)
Kato, Atsushi
Ishikawa, Fumihiro
Takeshita, Kei
Abrégé
A collagen production accelerator, for accelerating production of collagen in cells, containing at least one substance selected from the group consisting of 1,5-anhydro-D-glucitol and derivatives thereof. In addition, a composition containing the collagen production accelerator. This collagen production accelerator containing 1,5-AG or a derivative thereof accelerates production of collagen in cells, and is therefore suitable for use in, e.g., a cosmetic, a medical formulation, or a food item to which the collagen production accelerator is added in order to prevent and/or mitigate skin wrinkling.
A61K 31/351 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle non condensés avec un autre cycle
Provided are: a liquid preparation for oral administration, which contains barium that can be mixed with residues readily and is rarely precipitated in the intestinal tract; and a liquid preparation for oral administration and a composition for imaging the digestive tract, each of which contains barium and enables the reduction of the dosage of an intestinal tract washing solution in a pretreatment of the intestinal tract. That is, provided are: a liquid preparation for oral administration, which comprises barium and at least one thickening agent selected from the group consisting of a naturally-occurring polysaccharide and a cellulose-type polymer, and has a viscosity of 100 mPa·s or more at a shear rate of 21.54 s-1 and 5 to 90 mPa·s at a shear rate of 464.1 s-1, wherein barium has such a volume cumulative distribution that the particle diameter D10 is 0.30 to 0.80 μm and the particle diameter D90 is 1.0 to 10 μm; and a liquid preparation for oral administration for use in the imaging of the digestive tract by CT colonography, which comprises barium and a water-soluble polymer or a salt-type purgative agent and is to be administered in an amount of 50 to 2000 mL in a single dose or several divided doses on the day before carrying out the CT colonography.
NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (Japon)
FUSHIMI Pharmaceutical Co., Ltd. (Japon)
Inventeur(s)
Kato, Atsushi
Takeshita, Kei
Ishikawa, Fumihiro
Abrégé
An osmotic pressure-controlling agent which comprises 1,5-D-anhydroglucitol represented by formula (I); and a peritoneal dialysate, an ophthalmic composition and a transfusion each containing said controlling agent. Since the aforesaid osmotic pressure-controlling agent has an excellent biocompatibility and a high safety but no bioaccumulative potential, it can be appropriately used in compositions the osmotic pressure of which should be controlled, such as a peritoneal dialysate, an ophthalmic composition and a transfusion. Since the osmotic pressure-controlling agent is a stable substance which does not undergo any reaction with another component or decomposition, a peritoneal dialysate, an ophthalmic composition and a transfusion containing said controlling agent may be in a form requiring no pharmaceutical procedure, for example, mixing with other components immediately before using.
A61K 31/7004 - Monosaccharides ayant uniquement des atomes de carbone, d'hydrogène et d'oxygène
A61M 1/14 - Systèmes de dialyseReins artificielsOxygénateurs du sang
A61P 7/08 - Substitut de plasmaSolutions de perfusionDyalisats ou hémodyalisatsMédicaments pour le traitement des troubles électrolytiques ou acido-basiques, p. ex. choc hypovolémique
A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (Japon)
FUSHIMI Pharmaceutical Co., Ltd. (Japon)
Inventeur(s)
Kato, Atsushi
Takeshita, Kei
Ishikawa, Fumihiro
Abrégé
Disclosed is a composition for ameliorating postcibal hyperglycemia which comprises at least one member selected from the group consisting of 1,5-D-anhydroglucitol, 1,5-D-anhydrofructose and derivatives of the same. Also disclosed is a composition for ameliorating postcibal hyperlipemia which comprises at least one member selected from the group consisting of 1,5-D-anhydroglucitol, 1,5-D-anhydrofructose and derivatives of the same. The aforesaid composition for ameliorating postcibal hyperglycemia and composition for ameliorating postcibal hyperlipemia are appropriately usable for ameliorating the symptoms of postcibal hyperglycemia and postcibal hyperlipemia in those who have these symptoms or signs thereof.
A23L 1/30 - contenant des additifs (A23L 1/308 a priorité);;
A61K 31/351 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle non condensés avec un autre cycle
Disclosed is a resin composition comprising: an epoxy compound composition comprising at least two epoxy compounds each of which has a phosphazene ring and an epoxy group, and each of which is produced by the reaction of a polyfunctional glycidyl compound (e.g., a glycidyl ether of Bisphenol A) with a hydroxy-containing cyclic phosphazene compound (e.g., a hydroxyphenoxy-phenoxy-mix-substituted cyclic phosphazene compound); and at least one resin component selected from the group consisting of a thermoplastic resin and a thermosetting resin. The resin composition is excellent in heat resistance, high-temperature reliability and flame retardancy, and enables to form a molded resin article having properties inherent to the resin component. The molded resin article can be used as a sealing agent for an electronic component (e.g., an LSI), a substrate or the like.
[PROBLEMS] To provide a thermostable L-ribose isomerase. [MEANS FOR SOLVING PROBLEMS] There is provided a thermostable L-ribose isomerase having physical and chemical properties such that molecular weight: 32,000 (SDS-PAGE), optimum temperature: 45°C, optimum pH: 9.0 (glycine-NaOH buffer) and temperature stability: being stable up to 45°C in heat treatment at pH 9.0 for 10 min, which thermostable L-ribose isomerase has the activity of isomerizing L-ribose into L-ribulose and reversely isomerizing L-ribulose into L-ribose. The thermostable L-ribose isomerase is an enzyme derived from Raoultella ornithinolytica MB426(NITE BP-277) (1). There is provided a method of conversion between aldose and ketose, characterized in that an aldose selected from among L-ribose, D-lyxose, D-talose, D-mannose, L-allose and L-gulose is acted on by the above thermostable enzyme to isomerize the aldose, thereby producing the corresponding ketose selected from among L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose, respectively, or alternatively a ketose selected from among L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose is acted on by the above L-ribose isomerase to isomerize the ketose, thereby producing the corresponding aldose selected from among L-ribose, D-lyxose, D-talose, D-mannose, L-allose and L-gulose, respectively.
[PROBLEMS] To provide a microorganism being capable of producing deoxy polyol dehydrogenase. [MEANS FOR SOLVING PROBLEMS] A microorganism belonging to the genus Enterobacter which is capable of producing deoxy polyol dehydrogenase having the same structure as ribitol or L-iditol at the C2- and C3-positions. This microorganism is Enterobacter sp. IK7 (Deposition No. NITE P-271). A method of producing a deoxyketose characterized by comprising treating a solution containing a deoxy polyol having the same structure as ribitol or L-iditol at the C2- and C3-positions with a culture medium containing deoxy polyol dehydrogenase, which has been obtained by culturing the above described microorganism, or the deoxy polyol dehydrogenase, thus oxidizing the deoxy polyol to form the corresponding deoxyketose, and then harvesting the same. The deoxy polyol is 1-deoxy D-allitol and the corresponding deoxyketose is 1-deoxy L-psicose. Alternatively, the deoxy polyol is L-rhamnitol and the corresponding deoxyketose is 1-deoxy-L-fructose.
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
It is intended to provide 1- or 6-deoxy forms corresponding to all the aldohexoses, ketohexoses and sugar alcohols based on deoxyizumoring, and a method for systematically producing the same. A method for producing a deoxyketohexose and a derivative thereof, characterized by producing a corresponding 1-deoxy-D-ketohexose, 6-deoxy-D-ketohexose, 1-deoxy-L-ketohexose or 6-deoxy-L-ketohexose, which is an objective substance, by epimerization of the 3-position of a 1-deoxy-D-ketohexose, 6-deoxy-D-ketohexose, 1-deoxy-L-ketohexose or 6-deoxy-L-ketohexose, which is a raw material, using a deoxyketohexose isomerase derived from Pseudomonas cichorii ST-24 (FERM BP-2736).
Phosphazenes which can effectively enhance the flame retardance of resin moldings without impairing the mechanical characteristics thereof and which little impair the high-temperature reliability of the moldings and the dielectric characteristics thereof are represented by the general formula (1): (1) wherein n is an integer of 3 to 15; and A’s are each a member selected from the group consisting of alkoxy, aryloxy, and cyanato-bearing groups, with the proviso that at least one of A’s is a cyanato-bearing group such as cyanatophenyl-substituted phenyloxy represented by the general formula (4) wherein Y is O, S, SO2, CH2, CHCH3, C(CH3)2, C(CF3)2, C(CH3)CH2CH3, or CO: (4)
C07F 9/6581 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle comportant des atomes de phosphore, avec ou sans atomes d'azote, d'oxygène, de soufre, de sélénium ou de tellure, comme hétéro-atomes du cycle comportant des atomes de phosphore et d'azote, avec ou sans atomes d'oxygène ou de soufre, comme hétéro-atomes du cycle
C08G 79/02 - Composés macromoléculaires obtenus par des réactions créant dans la chaîne principale de la macromolécule une liaison contenant des atomes autres que le silicium, le soufre, l'azote, l'oxygène et le carbone, avec ou sans ces derniers éléments créant une liaison contenant du phosphore
