Particular embodiments disclosed herein provide a method for training a machine learning model to estimate the clinical significance of floaters in a patient's eye. One or more images, such as SLO images or en face retinal OCT images, are evaluated to identify shaded regions corresponding to floaters. The shaded regions are measured and the measurements processed using a machine learning model to obtain an estimated significance. The machine learning model is then updated according to a comparison of the estimated significance to a human-assigned clinical significance. The machine learning model may additionally or alternatively be updated by evaluating the estimated category with respect to visibility threshold data, such as one or more visibility threshold surfaces defined with respect to two or more variables.
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
A61B 3/12 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p. ex. ophtalmoscopes
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
3.
PSYCHOPHYSICAL EVALUATION OF THE EFFECT OF VITREOUS FLOATERS
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
A61B 3/12 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p. ex. ophtalmoscopes
A61F 9/008 - Procédés ou dispositifs pour la chirurgie de l'œil utilisant un laser
4.
VITREOUS FLOATER TREATMENT USING RESONANT SCANNER-BASED SLO
Aspects of the present disclosure provide techniques for performing a safety test of a laser diode associated with an ophthalmic surgical apparatus. An example method determining a measured slope efficiency of the laser diode based on a plurality of different current levels applied to an input of the laser diode and a plurality of different output power levels associated with the laser diode, determining an expected slope efficiency of the laser diode based on a measured operating temperature of the ophthalmic surgical apparatus, determining a result of the safety test of the laser diode based on the measured slope efficiency of the laser diode and the expected slope efficiency for the laser diode, and outputting an electrical signal indicating a result of the safety test of the laser diode.
A syringe with multiple chambers of isolated constituents for advancing to a mixing chamber in furtherance of delivery to tissue within an eye of a patient. The syringe also includes a mixing mechanism that is in communication with the mixing chamber. Additionally, the isolated chambers may be one of sequential or side by side / parallel depending on the types of constituents to be combined and other surgical preferences.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
A61M 5/19 - Seringues avec plusieurs compartiments
A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
Systems and methods are disclosed for flexibly controlling laser pulses being output from a laser system. An example surgical system comprises a laser, a laser energy control system configured to regulate the amount of electromagnetic energy of each laser pulse that exits the laser system, and a laser pulse controller. The control signals communicated by the laser pulse controller may include a sub-carrier signal that modulates the amount of electromagnetic energy of the laser pulses that exit the laser system. The control signals may further include a threshold signal and/or a maximum power signal. The sub-carrier signal may oscillate between the threshold power and a maximum power.
Systems and methods are disclosed for flexibly controlling laser pulses being output from a laser system. An example surgical system comprises a laser, an optical switching device, and a laser pulse controller. Optical switching control signals communicated by the laser pulse controller control the length of a pulse picking cycle and the number of laser pulses in each pulse picking cycle to be output from the laser system. The number of laser pulses in each pulse picking cycle to be output from the laser system may be adjustable in a range that includes more than 50% of the laser pulses in each pulse picking cycle.
Embodiments of the present disclosure relate to improved surgical laser systems (100) with single-core single-optical fiber-illuminated laser probes (108), which are configured to propagate both treatment laser beams (113) and illumination light beams (150). More particularly, embodiments of the present disclosure provide surgical laser systems with color adjustability of illumination light, as well as improved laser probe stiffness.
A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
A61B 1/07 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement utilisant des moyens conduisant la lumière, p. ex. des fibres optiques
A61B 3/00 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/20 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers
A61B 18/22 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
A61F 9/008 - Procédés ou dispositifs pour la chirurgie de l'œil utilisant un laser
G02B 6/036 - Fibres optiques avec revêtement le noyau ou le revêtement comprenant des couches multiples
Certain embodiments provide a method of performing ophthalmic surgical procedures. The method includes ingesting and preparing pre-operative data and intra-operative data associated with a patient's eye for further processing. In certain embodiments, the method further includes integrating the pre-operative data and intra-operative data to generate context sensitive data for further processing. The method also includes classifying and annotating the pre-operative data, the intra-operative data, and the context sensitive data. The method also includes extracting one or more actionable inferences from the pre-operative data, the intra-operative data, context sensitive data, and the classified and annotated data. The method further includes triggering, based on the one or more actionable inferences, one or more actions on an imaging system or a surgical system.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
A61F 9/008 - Procédés ou dispositifs pour la chirurgie de l'œil utilisant un laser
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
12.
OPHTHALMIC IMAGE REGISTRATION USING INTERPRETABLE ARTIFICIAL INTELLIGENCE BASED ON DEEP LEARNING
In certain embodiments, an ophthalmic system and computer-implemented method for performing ophthalmic image registration are described. The ophthalmic image registration includes obtaining a plurality of images of an eye of a user. Within each image of the plurality of images, a segmented region(s) of the eye within the image is determined based on evaluating the image with a neural network(s), and a set of point features of the eye within the segmented region(s) of the eye is determined based on evaluating the image with the neural network(s). A set of transformation information for transforming at least one of the plurality of images is generated based on performing one or more image processing operations on the set of point features within each image of the plurality of images. At least one of the plurality of images is transformed, based on the set of transformation information.
G06T 7/33 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur les caractéristiques
13.
SLO-BASED LASER GUIDANCE FOR TREATING VITREOUS FLOATERS
In certain embodiments, an ophthalmic surgical laser system for imaging and treating an eye floater includes an SLO subsystem, a treatment laser subsystem, a scanner, optical elements, and a computer. The SLO subsystem provides an SLO laser beam with an SLO focal point, and the treatment laser subsystem provides a treatment laser beam with a treatment focal point that spatially coincides with the SLO focal point. The scanner scans the SLO laser beam across a scan region and directs the treatment laser beam to the xy-location of the scan region. The optical elements aim the SLO laser beam and the treatment laser beam at substantially the same point of the scan region. The computer receives an SLO image of the floater, determines an xy-location of the floater, and instructs the treatment laser subsystem to direct the treatment laser beam towards the xy-location and the z-scan location of the floater.
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
A61B 3/12 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p. ex. ophtalmoscopes
A61F 9/008 - Procédés ou dispositifs pour la chirurgie de l'œil utilisant un laser
A platform configured to secure a service loop of tubing from a fixed position surgical device. The platform allows for avoidance of taping and re-taping of service loops. Additionally, the platform provides stability to the surgical device so as to avoid unintentional changing of position or orientation of the device. This is of particular benefit for an infusion port during eye surgery and other similar devices where orientation of the installed device aids device performance.
An apparatus (100) for eye surgery. Some embodiments may comprise a housing (110), a bore through the housing, and a push rod (115) at least partially disposed in the bore. The push rod may be operable to move between three rod positions within the bore. A plunger key may be coupled to the housing and operable to move between three key positions. In the first key position, the plunger key may prevent the push rod from moving from a first rod position. In the second key position, the plunger key may allow the push rod to slide through the bore from the first rod position to a second rod position. In the second key position, the plunger key may also allow the push rod to be rotated to advance to a third rod position. In the third key position, the plunger key may allow the push rod to slide through the bore from the second rod position to the third rod position.
Certain aspects provide an intraocular lens (IOL) including a monolithic lens body having an anterior nanostructure assembly on an anterior outer surface of the monolithic lens body and a posterior nanostructure assembly on a posterior outer surface of the monolithic lens body, and one or more haptics coupled to the monolithic lens body.
Certain embodiments provide an intraocular lens (IOL) including a lens body having a monolithic anterior lens element having an anterior nanostructure assembly formed thereon and a monolithic posterior lens element having a posterior nanostructure assembly formed thereon, and one or more haptics coupled to the lens body.
Certain embodiments provide an intraocular lens (IOL) including a lens body having an anterior lens element and a posterior lens element, and an optical fluid in a cavity formed between the anterior lens element and the posterior lens element. The anterior lens element and the posterior lens element each comprise a lens material having a first Abbe number, and the optical fluid has a second Abbe number that is less than the first Abbe number.
A robotic imaging system includes a camera configured to obtain one or more images of a target site. A robotic arm is operatively connected to the camera, the robotic arm being adapted to selectively move the camera in a movement sequence. A force-based sensor is configured to detect and transmit sensor data related to at least one of force and/or torque imparted by a user for moving the camera. The system includes a controller configured to receive the sensor data. The controller has a processor and tangible, non-transitory memory on which instructions are recorded. The controller is adapted to selectively execute a collision avoidance mode, including applying a respective correction force to modify the movement sequence when the camera and/or the robotic arm enter a predefined buffer zone.
An apparatus for folding an intraocular lens or other implant before inserting it into an eye in various locations using variable surgical techniques. Some embodiments may comprise or consist essentially of a haptic folding mechanism configured to fold one or more haptics onto the top of an optic prior to the optic being folded into a nozzle. In some embodiments, a leading haptic lifter (305) or lifting mechanism can be configured to elevate and constrain a leading haptic (225) during implant delivery. This leading haptic folding mechanism can passively lift the leading haptic onto the top of the optic.
A robotic imaging system includes a stereoscopic camera configured to record left and right images of a target site. A robotic arm is operatively connected to the stereoscopic camera, the robotic arm being adapted to selectively move the stereoscopic camera relative to the target. The stereoscopic camera includes an optical assembly having at least one lens and defining a working span. The optical assembly has at least one focus motor adapted to move the at least one lens to selectively vary the working span. The robotic imaging system includes a controller having a processor and tangible, non-transitory memory on which instructions are recorded. The controller is adapted to selectively execute an orbital scanning mode causing the robotic arm to sweep an orbital trajectory at least partially circumferentially around the eye while maintaining focus.
A61B 3/12 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p. ex. ophtalmoscopes
A robotic imaging system includes a camera configured to obtain one or more images of a target site. A robotic arm is operatively connected to the camera, the robotic arm being adapted to selectively move the camera in a movement sequence. The robotic imaging system includes a sensor configured to detect and transmit sensor data related to a respective position and/or a respective speed of the camera. A controller is configured to receive the sensor data, the controller having a processor and tangible, non-transitory memory on which instructions are recorded. The controller is adapted to selectively execute a collision avoidance mode, which includes determining a trajectory scaling factor for the camera. The trajectory scaling factor is applied to modulate the respective speed when the camera and/or the robotic arm are in a predefined buffer zone.
An ultrasonic handpiece includes a piezoelectric element assembly. Control signals drive the piezoelectric element assembly simultaneously in a first mode of oscillation and a second mode of oscillation. Feedback of a resulting oscillation of the piezoelectric element assembly in the first mode and the second mode is generated. Based on the feedback, the frequency of each of the first mode and second mode is independently adjusted, as needed, so that the resulting oscillation of each of the first mode and the second mode is each approximately at its respective resonant frequency.
Provided herein are methods of synthesizing netarsudil, and intermediates thereof, in high yield and at large com¬ mercial scale. A key intermediate in this synthesis is the preparation of piperidinium (S)-3-((tert-butoxycarbonyl)amino)-2-(4-(((2,4- dimethylbenzoyl)oxy)methyl)phenyl)propanoate, a salt that has been found to be easily purified by recrystallization.
C07C 271/22 - Esters des acides carbamiques ayant des atomes d'oxygène de groupes carbamate liés à des atomes de carbone acycliques avec les atomes d'azote des groupes carbamate liés à des atomes d'hydrogène ou à des atomes de carbone acycliques à des atomes de carbone de radicaux hydrocarbonés substitués par des groupes carboxyle
C07D 217/02 - Composés hétérocycliques contenant les systèmes cycliques de l'isoquinoléine ou de l'isoquinoléine hydrogénée avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone du cycle contenant l'azoteAlkylène-bis-isoquinoléines
C07D 295/027 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle contenant uniquement des atomes d'hydrogène et de carbone en plus des hétéro-éléments du cycle ne contenant qu'un hétérocycle
Implant delivery devices, methods of device assembly and methods of using those devices are presented, where the delivery device uses an automatic implant delivery mechanism that eliminates variability in pusher wire speeds by providing a needle assembly having one or more implants positioned within a proximal end of a needle cannula (10), a dampener assembly (13) and a shuttle assembly (14) located within a housing along with the activation member (5), which holds the shuttle assembly (14) in cocked or pre-tensioned state. A lock can be engaged with the activation member (14) to prevent premature firing or triggering of the device.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
A medical implant is disclosed. The medical implant includes a body having a first end having a first cross-sectional dimension, a second end having a second cross-sectional dimension, and a tapered portion extending between the first end and the second end. The first cross-sectional dimension is larger than the second cross-sectional dimension. In some embodiments, the body comprises multiple layers.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The procedure and surgical information alert system (10) is a surgical management system for capturing, storing, processing, tracking, and sharing patient and procedural identification data, including implant data, during medical/surgical procedures performed at multiple medical offices (20) and/or surgical center (30) locations. The procedure and surgical information alert system (10) allows for accurate verification of the predetermined procedure verified between the physician and patient during the scheduling process at a medical office (20), which is confirmed at that time by the patient's signature. On the day of the surgical procedure, the patient information is re-verified by the patient at a surgery center. Prior to the surgical procedure, a time-out alert warning (240) is generated to freeze use of the system until physician verification of the patient information is confirmed. Implant inventory alert warnings (192) are provided to authorized surgery center staff based on predictive implant inventory needs.
G06F 3/048 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI]
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
G16H 70/20 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des pratiques ou des directives
28.
RADIALLY REPULSIVE MAGNETIC BEARING FOR SELF-ALIGNING ELEMENTS OF COUPLED PLATFORMS
Apparatus for self-aligning elements of coupled platforms includes a radially repulsive magnetic bearing. The radially repulsive magnetic bearing includes a first axially polarized magnet (312) and a second axially polarized magnet (314) that is concentrically disposed around the first axially polarized magnet and radially repulsive to the first axially polarized magnet. The radially repulsive magnetic bearing is configured to align a first element (304) of a first platform with a second element (306) of a second platform when the first and second platforms are coupled together.
An ocular implant including a drug releasing element and having an inlet portion and a Schlemm's canal portion distal to the inlet portion, the inlet portion being disposed at a proximal end of the implant and sized and configured to be placed within an anterior chamber of a human eye, the Schlemm's canal portion being arranged and configured to be disposed within Schlemm's canal of the eye when the inlet portion is disposed in the anterior chamber.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
30.
AZABICYCLO AND DIAZEPINE DERIVATIVES FOR TREATING OCULAR DISORDERS
The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. For example, the present invention provides compounds of Formula (I):In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61P 27/10 - Agents ophtalmiques pour le traitement des troubles d'accommodation, p. ex. myopie
An intraocular lens, wherein an outer periphery of an optic portion has a peripheral surface, and a radially inner portion of a peripheral portion of the IOL has an inner surface, wherein the peripheral surface is directly adjacent to the inner surface, and wherein the peripheral surface does not directly extend (coupled to or integrally formed therewith) from the inner surface, and wherein the peripheral surface and the inner surface are configured so that the peripheral portion is stabilized in at least one of, and optionally both of, the proximal and distal directions relative to the optic portion.
G02B 1/06 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de fluides en cellules transparentes
G02B 3/12 - Lentilles remplies d'un fluide ou à l'intérieur desquelles le vide a été fait
32.
DUAL-EDGE SAMPLING WITH K-CLOCK TO AVOID ALIASING IN OPTICAL COHERENCE TOMOGRAPHY
Techniques and apparatus for producing sampled Optical Coherence Tomography (OCT) interference signals without aliasing, based on a swept-source OCT interference signal. An example apparatus comprises a k-clock circuit configured to selectively output a k-clock signal at any of a plurality of k-clock frequencies ranging from a minimum k-clock frequency to a maximum k-clock frequency, and an anti-aliasing filter configured to filter a swept- source OCT interference signal, to produce a filtered OCT interference signal, where the anti- aliasing filter has a cut-off frequency greater than one-half the minimum k-clock frequency but less than the minimum k-clock frequency. The apparatus further comprises an analog-to- digital (A/D) converter circuit configured to sample the filtered OCT interference signal at twice the k-clock frequency, to produce a sampled OCT interference signal. In some embodiments, the A/D converter circuit samples the filtered OCT interference signal at both rising and falling edges of the k-clock signal.
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G01B 9/02091 - Interféromètres tomographiques, p. ex. à cohérence optique
33.
FOOT PEDAL CONTROLLED OCT-DISPLAY FOR VITREORETINAL SURGERY
OCT-display for vitreoretinal surgery may be foot pedal controlled. Specifically, the tissue layers displayed in an en face image generated from OCT scanning may be navigated downward or upward based on user input supplied by a foot pedal device.
Systems and methods for non-invasively assessing ciliary muscle accommodative potential in phakic eyes may include receiving a plurality of signals generated by a plurality of bipolar electrodes during a ciliary muscle assessment procedure, each of the plurality of signals indicating an electrical field associated with a patient's ciliary muscle, and analyzing the signals to evaluate the patient's ciliary muscle accommodative potential.
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/296 - Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électromyographie [EMG]
A customized surgical profile is validated for execution on a surgical system. In some aspects, a customized ophthalmic surgical profile, which includes a surgical pattern and at least one parameter associated with the surgical pattern, is obtained. A pattern definition file executable by a laser-based ophthalmic surgical system is generated based on the customized ophthalmic surgical profile. Execution of the customized ophthalmic surgical profile on the laser-based ophthalmic surgical system is simulated based on the pattern definition file, and the pattern definition file is validated based on an output of the simulation.
Laser pulse modulation for laser corneal treatments is used to control the thermal energy imparted to the cornea. The optical energy of the laser pulses may be modulated to reduce or increase the thermal energy, depending upon an expected thermal load or a measured temperature at each position location of the cornea subject to laser treatment. The laser pulse modulation may involve pulse frequency modulation, pulse amplitude modulation, and pulse duration modulation.
In certain embodiments, a system for tracking movement of an eye comprises a camera system, a computer system, and an output device. The camera system generates images of the eye. The computer system stores the images and at least one of the images as a reference image. The computer system also tracks movement of the eye within a tracking range by comparing a current image with the reference image, and by determining a movement of the eye from the comparison of the current image and the reference image. The tracking range has one or more alert points. The computer system also determines an orientation of the eye relative to at least one alert point of the tracking range. The output device outputs a range indicator that indicates the orientation of the eye relative to the at least one alert point of the tracking range.
A61B 3/113 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour déterminer ou enregistrer le mouvement de l'œil
38.
PHASE-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY TO MEASURE OPTICAL ABERRATIONS IN ANTERIOR SEGMENT
Techniques for measuring optical aberrations of the eye are disclosed. An example method comprises positioning the eye in a measurement location adjacent to a measurement arm of an optical coherence tomography (OCT) interferometer apparatus, so that source light from the measurement arm passes into the anterior segment of the eye and detecting an interference pattern, the interference pattern resulting from a combination of light reflected from the eye and light reflected from a reference arm of the OCT interferometer apparatus. Based on the interference pattern, an optical delay between a reference surface in the anterior segment of the eye and a measured surface in the eye is calculated, the reference surface being the anterior surface of the cornea or the lens, wherein said calculating comprises measuring an optical phase shift between the reference surface and the measured surface, based on the detected interference pattern.
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
Provided herein are cannula devices that are self-illuminating to facilitate visualization of the cannula devices during a surgical procedure. The self-illuminating feature may be provided by phosphors incorporated into the cannula device, for example in the hub or sealing element of the cannula device. The cannula device may emit light of a specific color selected to correspond to a size of the cannula device.
The present disclosure provides a femtosecond laser docking apparatus that includes a suction cone, with an upper frusto-conical portion and lower spherical portion, and a suction ring, with a mechanical stop and at least one contact and sealing surface. The mechanical stop engages the spherical portion of the suction cone to prevent it from being lowered further toward an eye, in a z-direction, beyond the mechanical stop. This disclosure provides a system for femtosecond laser ophthalmic surgery that includes a suction cone, with an upper frusto-conical portion and lower spherical portion, and a suction ring. This disclosure further provides a method for docking a femtosecond laser that includes positioning a suction ring on an eye, lowering a suction cone toward the eye until it engages the mechanical stop of the suction ring, and applying suction to seal the suction cone to the suction ring by a contact and sealing surface.
An ophthalmic lens includes an optic comprising an anteriorsurface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface has a surface profile including a base curvature and a plurality of morphed sinusoidal phase shift structures. The base curvature may correspond to a base optical power of the ophthalmic lens, and the morphed sinusoidal phase shift structures may be configured to extend depth of focus of the ophthalmic lens at intermediate or near viewing distances.
Intraocular lens systems and methods for assembling thereof are disclosed. The intraocular lens system includes a base and a lens insertable into and removable from a recess. The lens includes a central optic, a first tab protruding radially away from the central optic, and a second tab protruding radially away from the central optic. The first tab includes first, second and third arms, such that each of the first and second arm has one end connected to an edge of the central optic and the other end connected to the third arm. One or more of the first, second, and third arms is configured to deform to move the first tab between a compressed state and an extended state, and wherein in the extended state of the first tab, an obtuse angle is formed between the first and second arms.
In some embodiments, a vitrectomy probe may include an inner cutting tube reciprocating in an outer tube. The outer tube includes a side port and the inner tube includes a distal cutting port, and, in some embodiments, an additional side port. In some embodiments, the inner tube may also include a flat upper edge that cuts across the outer tube side port. In some embodiments, a diaphragm drives the inner tube and may have an open-stroke side with a lower hardness material than a closed-stroke side. In some embodiments, an aspiration tube coupled to the vitrectomy probe may include a first aspiration tubing and a second aspiration tubing with a lower hardness than the first aspiration tubing. In some embodiments, the vitrectomy probe may be coupled to pneumatic tubing that is stepped or tapered.
Systems and methods for high-resolution, wide-angle viewing of a retina of an eye using an ophthalmic microscope that can view a high-resolution image of a retina formed using a wide field of view optical system. A wide field of view optical system can involve a first lens having a diffractive surface on at least one surface and a second lens housing in a shared housing. A wide field of view optical system can involve one or more lens formed from an optical grade polymer and manufactured at a cost that allows the lens to be disposable.
A61B 3/125 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p. ex. ophtalmoscopes avec des lentilles de contact
An ophthalmic laser system includes a laser engine to generate a beam of femtosecond laser pulses, a laser scanner to scan each laser pulse of the beam in three dimensions according to a scan pattern, and a compound lens comprising a glass lens and a birefringent lens, the compound lens arranged to receive the scanned beam and configured to split each laser pulse of the scanned beam into an ordinary pulse and an extraordinary pulse, producing an ordinary beam comprising ordinary pulses and an extraordinary beam comprising extraordinary pulses.
A valved trocar cannula for insertion into an eye includes a trocar cannula having a distal end configured to be positioned within the eye and a proximal end configured to be positioned outside the eye. An elastomeric membrane or seal is attached to the trocar cannula at the proximal end thereof and restricts a free flow of fluid from within the trocar cannula to outside the proximal end of the trocar cannula. The elastomeric membrane includes at least one slit extending therethrough and is arranged to permit the passage of a surgical instrument through the membrane and into the trocar cannula. The slit may through the elastomeric membrane at an oblique angle along a least a portion of the slit. Pressure applied across a first surface or a second surface of the elastomeric membrane in a vicinity of the slit tends to keep the slit in a closed position.
A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
A61M 39/06 - Soupapes hémostatiques, c.-à-d. éléments formant joint autour d'une aiguille, d'un cathéter ou similaire, et se fermant après leur retrait
The present invention generally relates to inherently wettable silicone hydrogel contact lenses formed from a silicone hydrogel lens formulation that comprises a polysiloxane vinylic crosslinker having H-donor moieties, a siloxane-containing vinylic monomer with or without H-donor moieties, and a N-vinyl amide monomer. The inherently wettable silicone hydrogel contact lenses can have a combination of the desired contact lens properties including relatively high oxygen permeability, relatively high water content, relatively low modulus, and relatively-low surface atomic Si percentage. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
The present invention generally relates to inherently wettable silicone hydrogel contact lenses formed from a silicone hydrogel lens formulation that comprises a polysiloxane vinylic crosslinker having H-donor moieties, a siloxane-containing vinylic monomer with or without H-donor moieties, and a N-vinyl amide monomer. The inherently wettable silicone hydrogel contact lenses can have a combination of the desired contact lens properties including relatively high oxygen permeability, relatively high water content, relatively low modulus, and relatively-low surface atomic Si percentage. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
B29D 11/00 - Fabrication d'éléments optiques, p. ex. lentilles ou prismes
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
Disclosed are high refractive index, hydrophobic, acrylic materials. These materials have both high refractive index and a high Abbe number. This combination means the materials have a low refractive index dispersion and thus are especially suitable for use as intraocular lens materials. The materials are also suitable for use in other implantable ophthalmic devices, such as keratoprostheses, corneal rings, corneal implants, and corneal inlays.
An ophthalmic lens includes an optic comprising an anterior surface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface has a surface profile including a base curvature, a refractive region having the base curvature, and a diffractive region comprising a diffractive profile including a plurality of diffractive steps. At least a portion of the diffractive profile constitutes a combination of a base diffractive profile defining multiple foci for the ophthalmic lens and an achromatizing structure that reduces longitudinal chromatic aberrations.
A stereoscopic visualization camera and platform are disclosed. An example stereoscopic visualization camera includes a first plurality of lenses positioned along a first optical path and a first image sensor to record a first image stream of a target site from light in the first optical path. The stereoscopic visualization camera also includes a second plurality of lenses positioned along a second optical path, parallel to the first optical path, and a second image sensor to record a second image stream of the target site from light in the second optical path. The stereoscopic visualization camera also includes a processor configured to reduce spurious parallax between the first and second images streams by selecting pixel sets of pixel grids of the first and second image sensors such that zoom repeat points ("ZRP") are located at a center of the respective pixel grids.
A61B 90/20 - Microscopes chirurgicaux caractérisés par des aspects non optiques
G02B 15/14 - Objectifs optiques avec moyens de faire varier le grossissement par déplacement axial d'au moins une lentille ou de groupes de lentilles relativement au plan de l'image afin de faire varier de façon continue la distance focale équivalente de l'objectif
G02B 30/22 - Systèmes ou appareils optiques pour produire des effets tridimensionnels [3D], p. ex. des effets stéréoscopiques en fournissant des première et seconde images de parallaxe à chacun des yeux gauche et droit d’un observateur du type stéréoscopique
H04N 13/239 - Générateurs de signaux d’images utilisant des caméras à images stéréoscopiques utilisant deux capteurs d’images 2D dont la position relative est égale ou en correspondance à l’intervalle oculaire
52.
3D PRINTING OF AN INTRAOCULAR LENS HAVING SMOOTH, CURVED SURFACES
A continuous additive fabrication system (100) comprises a bath of photopolymer resin and a light source assembly (104) having a light source (112) and a motorized variable aperture (114). The light source assembly is operable to generate a focus point (108) in the bath of photopolymer resin, the shape of the focus point at a curing plane within the bath of photopolymer resin corresponding to the shape of the motorized variable aperture. The continuous additive fabrication system further comprises a platform (106) configured to support a build object and a drive mechanism (110) (coupled to at least one of the platform and the light source assembly) configured to continuously move the curing plane through the bath of photopolymer resin. A size and/or shape of the motorized variable aperture is changed while the curing plane in continuously moved through the bath of photopolymer resin.
B29C 64/135 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p. ex. par irradiation globale combinée avec un masque la source d’énergie étant concentrée, p. ex. lasers à balayage ou sources lumineuses focalisées
Fiber-based mode mixing techniques may be used to homogenize different modes in an optical fiber used for surgical illumination. A vibrating fiber mechanism may impart mechanical motion to a portion of the optical fiber to generate a homogeneous illumination field from a coherent light source.
A61B 3/00 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux
A61B 18/22 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet
A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
Techniques and apparatus for selectively producing half-depth and full-depth OCT images, based on a swept-source OCT interference signal. An example method comprises selecting from a first sampling rate and a second sampling rate, the second sampling rate being twice the first sampling rate, and sampling the swept- source Optical Coherence Tomography (OCT) interference signal at the selected sampling rate, using a k-clock signal having a frequency range corresponding to the first sampling rate, to produce a sampled OCT interference signal. The method further comprises processing the sampled OCT interference signal to obtain an OCT image, such that the resulting OCT image is a half-depth image in the event the first sampling rate is selected and a full-depth image in the event the second sampling rate is selected.
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
G01B 9/02091 - Interféromètres tomographiques, p. ex. à cohérence optique
A method and system provide a surgical handpiece including a housing (110) and a horn (102). The housing has a retrograde channel (112) and a chamber (114) therein. The retrograde channel connects an irrigation line (120) and the chamber. The horn is held within the housing such that a portion of the horn resides within the chamber.
An optical coherence tomography system (150, 150') includes a light source (152, 152'), an interferometric system (160, 160'), a processor (182) and a memory (184). The interferometric system (160) is optically coupled with the light source (152) and includes at least one movable scanning mirror (170, 170', 170"). The processor (182) and memory (184) are coupled with the interferometric system (160, 160'). The processor (182) executes instructions stored in the memory (184) to cause the movable scanning mirror (170, 170', 170") to scan a plurality of points in a sample in at least one pattern (250, 250', 252, 254, 256). The at least one pattern is based on at least one of at least one Lissajous curve (250, 250', 252, 254) and at least one Spirograph curve (256).
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
An intraocular lens injector is disclosed. The injector (10) includes a passage (64) formed in a distal end portion (60) of the intraocular lens injector. The passage defines an interior surface (710), and a ramp (708) is formed on the interior surface so as to cause a leading haptic (450) of an intraocular lens (70) being advanced through the passage to lift above a surface of an optic (460) of the IOL to ensure proper folding of the IOL.
An apparatus for implanting an intraocular lens into an eye is described. The intraocular lens injector (10) includes a passage (64) formed in a distal end portion (60) of the intraocular lens injector. The passage defines an interior surface (1009), and one or more rails (1010,1012) are formed on the interior surface so as to displace an optic (460) of an intraocular lens (70) being advanced through the passage towards a portion of the interior surface disposed opposite the one or more rails.
A method and system provide an ophthalmic device. The ophthalmic device includes an ophthalmic lens having anterior surface, a posterior surface and at least one diffractive structure including a plurality of zones. The at least one diffractive structure is for at least one of the anterior surface and the posterior surface. Each zone includes at least one echelette having a least one step height. The step height(s) are individually optimized for each zone. To compensate chromatic aberration of eye from distance to a range of vision, a greater than 2p phase step height may be employed and the step height(s) folded by a phase, which is an integer multiple of two multiplied by p. Hence chromatic aberration of eye may be compensated to improve vision from distance to near.
A method and system provide a multifocal ophthalmic device. The ophthalmic lens has an anterior surface, a posterior surface and at least one diffractive structure including a plurality of echelettes. The echelettes have at least one step height of at least one wavelength and not more than two wavelengths in optical path length. The diffractive structure(s) reside on at least one of the anterior surface and the posterior surface. The diffractive structure(s) provide a plurality of focal lengths for the ophthalmic lens.
The present disclosure provides a system and method for monitoring phototoxicity caused by vitreous visualization device ("VVD") illumination during ophthalmic surgery. The systems and methods determine the cumulative amount of optical energy incident on the retina, which corresponds to phototoxicity, the distance between a cutter of the VVD and the retina, and areas where the vitreous has been removed, or any combination thereof. The disclosure further provides a method for monitoring and preventing phototoxicity caused by VVD illumination during ophthalmic surgery. The method may further include determining the distance between a cutter of the VVD and the retina, and determining areas where the vitreous has been removed based on focus areas of the retina that the plurality of light spots has contacted.
The present disclosure provides a visualization system for performing optimized optical coherence tomography (OCT) by determining the absolute distance between the OCT source and a sample. The present disclosure also provides a method for optimizing OCT, which includes determining an absolute distance between the OCT source and a sample using data relating to the focal length or position of an autofocus imager lens.
A61B 3/00 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
A61B 3/15 - Dispositions spécialement adaptées à la photographie de l'œil avec des moyens d'alignement, d'espacement ou de suppression des réflexions parasites
The invention provides a class of amphiphilic branched polydiorganosiloxane macromers and the uses thereof. Such a macromer comprises a polydiorganosiloxane polymer chain and two terminal groups free of any ethyleneically unsaturated group, wherein the polydiorganosiloxane polymer chain comprises (1) at least 5 dimethylsiloxane units in a consecutive sequence, (2) at least two first siloxane units each having methyl as one of the two substituents of each first siloxane unit and one first first organic radical having one sole (meth)acryloyl group as the othe substituent, (3) at least one second siloxane unit having methyl as one of the two substituents of the second siloxane unit and one second organic radical, which is free of any ethylenically unsaturated group and comprises one or more hydrophilic groups or polymer chains, as the other substituent.
C08F 299/08 - Composés macromoléculaires obtenus par des interréactions de polymères impliquant uniquement des réactions entre des liaisons non saturées carbone-carbone, en l'absence de monomères non macromoléculaires à partir de polycondensats non saturés à partir de polysiloxanes
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
64.
HYDROPHILIC COPOLYMER WITH ONE THIOL-CONTAINING TERMINAL GROUP
The invention is related to a class of hydrophilic polymers each comprising one sole thiol-containing terminal group. The hydrophilic polymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.
C08F 230/02 - Copolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et contenant du phosphore, du sélénium, du tellure ou un métal contenant du phosphore
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.
C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
C08L 29/14 - Homopolymères ou copolymères d'acétals ou de cétals obtenus par polymérisation d'acétals ou de cétals non saturés ou par post-traitement des polymères d'alcools non saturés
C08L 101/02 - Compositions contenant des composés macromoléculaires non spécifiés caractérisées par la présence de groupes déterminés
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
87573662 ABSTRACT The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses. Date Recue/Date Received 2020-12-29
87573657 ABSTRACT The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses. Date Recue/Date Received 2020-12-29
The invention provides a chain-extended polydiorganosiloxane vinylic crosslinker which comprises (1) a polymer chain comprising at least two polydiorganosiloxane segments and one hydrophilized linker between each pair of polydiorganosiloxane segements, wherein each polydiorganosiloxane comprises at least 5 dimethylsiloxane units in a consecutive sequence, wherein the hydrophilized linker is a divalent radical having at least two (meth)acrylamide moieties; (2) two terminal (meth)acryloyl groups, wherein the chain-extended polydiorganosiloxane vinylic crosslinker has an average molecular weight of at least about 1500 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a chain-extended polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising a chain-extended polydiorganosiloxane vinylic crosslinker of the invention.
C08G 77/20 - Polysiloxanes contenant du silicium lié à des groupes aliphatiques non saturés
C08G 77/28 - Polysiloxanes contenant du silicium lié à des groupes organiques contenant des atomes autres que le carbone, l'hydrogène et l'oxygène groupes contenant du soufre
C08G 77/392 - Polysiloxanes modifiés par post-traitement chimique contenant des atomes autres que le carbone, l'hydrogène, l'oxygène ou le silicium contenant du soufre
The invention provides a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer which comprises (1) a linear polymer chain comprising at least two polydimethylsiloxane segments, one hydrophilic polyoxyalkylene segment between each pair of polydimethylsiloxane segements, and one amide-rich linker between each pair of one polydimethylsiloxane segment and one hydrophilic polyoxyalkylene segment, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a weight average molecular weight of at least 3000 Daltons. The invention is also related to a silicone hydrogel contact lens produced from a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer of the invention.
An optical coherence tomography (OCT) system and a method for cross view imaging using the OCT system are disclosed. The OCT system comprises a processor coupled to a computer readable medium; and computer-executable instructions carried on the computer readable medium, the instructions readable by the processor, the instructions, when read and executed, for causing the processor to: acquire a first B-scan image and a second B-scan image; transform each B-scan image by applying a perspective transformation; and couple the first Bscan post-transformation image to the second B-scan post-transformation image at an angle to generate a cross view image, wherein the angle between the first B-scan post-transformation image and the second B-scan post-transformation image ranges between 30 degrees and 170 degrees.
A61B 3/00 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
A method and system provide an ophthalmic lens (110) including a lens body (120) having a chamber (126) therein, a reservoir module (130) coupled with the lens body and an optical fluid (140). At least part of the lens body is flexible. The reservoir module includes a reservoir (132A, 132B) and a heat sensitive portion (134) bordering the reservoir. The reservoir has a reservoir volume and is fluidically connected with the chamber. The heat sensitive portion has a shape responsive to a temperature of at least forty five degrees Celsius such that the reservoir volume changes in response to at least part of the heat sensitive portion reaching the temperature. The optical fluid resides in the chamber and the reservoir. A change in the reservoir volume flows a portion of the optical fluid between the reservoir and the chamber such that the flexible portion of the lens body undergoes a shape change corresponding to a base power change.
The invention is generally related to soft contact lenses which comprise a non-silicone hydrogel lens body and a hydrogel coating thereon. The non-silicone hydrogel lens body is composed of a hydrogel material which is free of silicone and comprises at least 50% by mole of repeating units of at least one hydroxyl-containing vinylic monomer. The hydrogel coating comprises a first polymeric material having first reactive functional groups and a hydrogel layer derived from a second polymeric material having second reactive functional groups, and the hydrogel layer is covalently attached onto the anchor layer through linkages each formed between one first reactive functional group and one second reactive functional group. The soft contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and has a friction rating of about 2 or lower after 7 cycles of manual rubbing, a water content of from about 10% to about 85% by weight and an elastic modulus of from about 0.2 MPa to about 1.5 MPa when being fully hydrated at room temperature.
B29D 11/00 - Fabrication d'éléments optiques, p. ex. lentilles ou prismes
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
73.
SUBTRACTIVE EN FACE OPTICAL COHERENCE TOMOGRAPHY IMAGING
En face or 3D volumetric OCT imaging during ophthalmic surgery may be performed with an OCT scanning controller that interfaces to an OCT scanner used with a surgical microscope. The OCT scanner may generate en face images before and after surgical operations, such as retinal membrane peeling, are performed. Using digital subtraction on the en face images, an overlay image indicative of the changes from the surgical operations to the eye may be generated and overlaid onto an optical image displayed to a user of the surgical microscope.
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
The present disclosure provides a capsulotomy device having a unique insertion sleeve configuration comprising beveling and two notches at the distal end of the insertion sleeve. The unique configuration assures that the motion the capsulotomy loop comprising the heating element goes through during deployment from and retraction into the insertion sleeve is minimized and predictable.
An ophthalmic surgical system comprises: a camera optically coupled to a surgical microscope; a virtual reality (VR) headset worn by a surgeon; and a VR data processing unit configured to communicate with the surgical microscope, the VR headset, and an ophthalmic surgical apparatus, wherein the VR data processing unit is configured to: project a real time video screen of video received from the camera into the VR headset; project a patient information screen into the VR headset to provide the patient information directly to the surgeon during ophthalmic surgery; project a surgical apparatus information screen into the VR headset; project a surgical apparatus input control screen into the VR headset to provide the surgeon with direct control over the surgical apparatus; and control which ones of the screens are visible in the VR headset based inputs indicating head movements of the surgeon as detected by the VR headset.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
76.
AUTOMATED VISCOUS FLUID CONTROL IN VITREORETINAL SURGERY
Ophthalmic surgical devices, systems, and methods for automatically controlling the injection or extraction of viscous fluids from a patient's eye are provided. A syringe pump connected with an actuation line and a powered syringe provides pressures for viscous fluid injection or extraction in a vitreous chamber of the eye. A sensor disposed adjacent to or inside the eye determines sensor data relating to an intraocular pressure (IOP). The controller receives the sensor data and regulates the injection or extraction of the viscous fluid in response to the detected IOP, such as by controlling the syringe pump. The controller may determine whether the IOP is above an upper threshold or below a lower threshold and may control the syringe pump to regulate the injection or extraction of viscous fluid to maintain the IOP between the upper and the lower thresholds.
A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
THE REGENTS OF THE UNVERSITY OF COLORADO, A BODY CORPORATE (USA)
ALCON INC. (USA)
Inventeur(s)
Kahook, Malik Y.
Sussman, Glenn
Zacher, Rudolph F.
Mclean, Paul J.
Atkinson, Robert E.
Abrégé
Intraocular lenses (lOLs) (300) that improve lens stability by, for example, increasing anterior-posterior stiffness of the lOL, increasing anterior-posterior dimensions of the lOL and/or increasing contact area with the equator of the bag to resist movement of the lOL as the bag collapses over time. These lOLs may be non-modular (single component) or modular (multiple component). In modular embodiments, the lOL system may include intraocular base and optic components, which, when combined, form a modular lOL.
In certain embodiments, an ophthalmic lens (100) includes an optic (102) having an anterior surface (14), a posterior surface (106), and an optical axis (108). At least one of the anterior surface and the posterior surface includes a first zone (112) extending from the optical axis to a first radial boundary and a second zone (114) extending from the first radial boundary to the edge of the optic. The first zone includes an inner region (116) and an outer region (118) separated by a phase shift feature (120), the phase shift comprising a ridge extending outwardly from the inner region and the outer region.
A method and system provide an ophthalmic device. The ophthalmic device includes an ophthalmic lens (110) having an anterior surface (112), a posterior surface (114), at least one diffractive structure (120) and at least one base curvature (130). The at least one diffractive structure for provides a first spherical aberration for a first focus corresponding to at least a first focal length. The at least one base curvature provides a second spherical aberration for at least a second focus corresponding to at least a second focal length. The first spherical aberration and the second spherical aberration are provided such that the first focus has a first focus spherical aberration and the second focus has a second focus spherical aberration. The first focus spherical aberration is opposite in sign to the second focus spherical aberration.
Described herein are UV-absorbing vinylic monomers conjugated to 2-aminobenzophenone derivatives and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet ("UV") radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.
C07C 225/22 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones ayant des groupes amino liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné
C07C 233/33 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons doubles avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone d'un cycle aromatique à six chaînons
C07C 235/84 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné avec l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle aromatique à six chaînons
The application is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The polymerizable silicone composition comprises repeating units of a polydiorganosiloxane having at least two thiol groups. The application is also related to a soft silicone contact lens.
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet ("UV") radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
The invention provides a class of amphiphilic branched macromers and the uses thereof. An amphiphilic branched polydiorganosiloxane macromer of the invention is produced from an a,?-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator by ATRP polymerization of one or more hydrophilic vinylic monomers. It comprises at least two polydiorganosiloxane polymer chains each having at most two terminal methacryloxy groups, dangling hydrophilic polymer chains each having a polymerizable or non-polymerizable terminal group, and one or more hydrophilic polymer chains as linkages between two polydiorganosiloxane chains. The present invention is also related to a silicone hydrogel contact lens, which comprises units derived from a polydiorganosiloxane-containing amphiphilic branched macromer of the invention.
C08F 283/12 - Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères prévus par la sous-classe sur des polysiloxanes
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
A powered case is provided that includes a case, configured to hold an electroactive medical device with an integrated battery; an energizing system, configured to provide electric energy; and an energy transfer system, configured to receive energy from the energizing system; and to transfer the received energy to the integrated battery of the electroactive medical device. Further, a medical device system is provided that can include an electroactive medical device, including an integrated battery; and a powered case, including a case, configured to hold the electroactive medical device with the integrated battery; an energizing system, configured to provide electric energy; and an energy transfer system, configured to receive energy from the energizing system; and to transfer the received energy to the integrated battery of the electroactive medical device.
H02J 7/02 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries pour la charge des batteries par réseaux à courant alternatif au moyen de convertisseurs
85.
UNI-PORT HYBRID GAUGE SURGICAL APPARATUSES AND METHODS
Systems, apparatuses, and methods include a surgical apparatus with a handle for grasping by a user and a multi-function surgical portion extending therefrom. The multi-function surgical portion may include an illuminator portion arranged to provide illumination to a surgical region of a patient during a surgical procedure, and tissue- treating portion coaxially aligned with the illuminator portion.
The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
C08G 77/16 - Polysiloxanes contenant du silicium lié à des groupes contenant de l'oxygène à des groupes hydroxyle
C08G 77/20 - Polysiloxanes contenant du silicium lié à des groupes aliphatiques non saturés
C08G 77/392 - Polysiloxanes modifiés par post-traitement chimique contenant des atomes autres que le carbone, l'hydrogène, l'oxygène ou le silicium contenant du soufre
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
87.
POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS
The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
C08G 77/14 - Polysiloxanes contenant du silicium lié à des groupes contenant de l'oxygène
C08G 77/16 - Polysiloxanes contenant du silicium lié à des groupes contenant de l'oxygène à des groupes hydroxyle
C08G 77/20 - Polysiloxanes contenant du silicium lié à des groupes aliphatiques non saturés
C08G 77/38 - Polysiloxanes modifiés par post-traitement chimique
C08G 77/392 - Polysiloxanes modifiés par post-traitement chimique contenant des atomes autres que le carbone, l'hydrogène, l'oxygène ou le silicium contenant du soufre
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
88.
FAST AND AUTOMATED SEGMENTATION OF LAYERED IMAGE WITH HEURISTIC GRAPH SEARCH
A method of processing an ophthalmic image includes: taking an image of an ophthalmic region involving an ophthalmic layer by an imaging system; constructing an image graph, comprising nodes connected by links and detected image data by an image processor; and performing a heuristic graph-search for a path on the image graph that corresponds to an image of the ophthalmic layer by assigning at least one of link-costs to links of the image graph and node-costs to nodes of the image graph; assigning heuristic-costs to at least one of the nodes and the links; creating extended paths by extending a selected path with extension links; determining path-costs of the extended paths by combining heuristic costs and at least one of link-costs and node-costs assigned to the extension-links; and selecting the extended path with the smallest path-cost.
The present invention relates to improved contact lens products which not only have an improved and sustainable wettability. The contact lens product of the invention comprises a soft hydrogel contact lens immersed and autoclaved in a packaging solution including a polyoxyethylene-polyoxybutylene block copolymer and a high molecular weight copolymer of N-vinylpyrrolidone and at least one amino-containing vinylic monomer. The present invention also provides methods for making contact lens products of the invention.
A61L 2/07 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques de la chaleur des gaz chauds de la vapeur
A61L 12/04 - Procédés ou appareils pour la désinfection ou la stérilisation des lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques, p. ex. l'électricité, des ultrasons ou l'ultrafiltration de la chaleur
B29D 11/00 - Fabrication d'éléments optiques, p. ex. lentilles ou prismes
B65B 25/00 - Emballage d'autres objets présentant des problèmes particuliers
B65B 55/22 - Immersion du contenu dans les liquides de protection
90.
WATER-SOLUBLE UV-ABSORBING COMPOUNDS AND USES THEREOF
Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV- absorbing contact lenses capable of blocking ultra-violet ("UV") radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.
B29D 11/00 - Fabrication d'éléments optiques, p. ex. lentilles ou prismes
C07C 225/22 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones ayant des groupes amino liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné
C07C 235/02 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone acycliques et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné
C07C 309/49 - Acides sulfoniques ayant des groupes sulfo liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné contenant des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso, liés au squelette carboné le squelette carboné étant substitué de plus par des atomes d'oxygène liés par des liaisons simples
C07D 249/20 - Benzotriazoles avec des radicaux aryle liés directement en position 2
C08F 16/38 - Homopolymères ou copolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un radical alcool, éther, aldéhyde, cétone, acétal ou cétal par un radical acétal ou cétal
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
An ophthalmic illumination system can include an optical fiber configured to transmit a light beam output by a light source and focused by a condenser. The optical fiber can include proximal, distal, and central portions. The proximal portion can be configured to receive the light beam focused by the condenser. The distal portion can be configured to emit the light beam to illuminate a surgical field. The central portion can extend between the proximal and distal portions. A core diameter of the proximal portion can be larger than core diameters of the central and distal portions. An ophthalmic illumination method can include focusing, using a condenser, a light beam emitted by a light source onto a proximal portion of an optical fiber. The method can also include transmitting, using the optical fiber, the light beam to a surgical field.
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Suisse)
ALCON INC. (USA)
Inventeur(s)
Kahook, Malik Y.
Sussman, Glenn
Zacher, Rudolph F.
Mclean, Paul J.
Uy, Harvey
Solomon, Kerry
Cionni, Robert
Abrégé
Modular lOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular lOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post- operatively.
Methods of manufacturing an optic of an accommodating intraocular lens to have an aspheric lens surface, including providing an optic comprising an anterior element and a posterior element that at least partially define an optic fluid chamber, wherein at least one of the anterior element and the posterior element has an external surface that is spherical; and prior to inserting the accommodating intraocular lens into an eye, changing the shape of the at least one of the anterior element and the posterior element from the spherical configuration to an aspherical configuration.
G02B 1/06 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de fluides en cellules transparentes
G02B 3/04 - Lentilles simples ou composées à surfaces non sphériques à surfaces continues engendrées par une rotation autour d'un axe, mais s'écartant d'une véritable sphère
G02B 3/06 - Lentilles simples ou composées à surfaces non sphériques à surfaces cylindriques ou en forme de tore
G02B 3/12 - Lentilles remplies d'un fluide ou à l'intérieur desquelles le vide a été fait
An intraocular inserter (100) comprising: an body (102) defining a first interior cavity (103; a pressurized gas canister (148) disposed in the cavity; an assembly (161) disposed within the cavity and moveable proximally relative to the inserter body, the assembly comprising: a housing (150); a second interior cavity (151) formed within the housing; and a moveable member (144) disposed within the second interior cavity, the member dividing the second interior cavity into a first portion (153) adapted to receive a compressed gas and a second portion (155) configured to contain a incompressible fluid, the member imparts a pressure from the pressurized gas to the incompressible fluid; and a plunger (182) movable in response to pressure imparted by the substantially incompressible fluid; an actuator (104) pivotably coupled to the inserter body, the actuator comprising a lever arm (220) that engages the assembly, the actuator operable to displace the assembly distally within the inserter body when the actuator is pivoted relative to the inserter body.
Systems, apparatuses, and methods include an intraocular lens (IOL) cart that may assist with inventory management and may help users identify an IOL for use in a particular surgical application. The IOL cart may include sensors and indicators that provide information to a user and may update IOL inventory automatically whenever the IOL cart is accessed by a user.
A61G 12/00 - Équipements pour donner des soins, p. ex. dans les hôpitaux, non couverts par l'un des groupes , p. ex. chariots pour le transport des médicaments ou de la nourritureTableaux d'ordonnances
An implant container (120) for containing an ocular implant is described herein. The implant container can releasably couple to an implant delivery device and provide at least partial alignment of the delivery device with an ocular implant during loading of the ocular implant onto the delivery device.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
97.
CONTROL OF SCANNING IMAGES DURING VITREORETINAL SURGERY
Control of scanning images during ophthalmic surgery may be performed with a scanning controller that interfaces to an optical scanner used with a surgical microscope. A scan control device may receive user input, including hands-free user input, for controlling an overlay image of scanning data that is overlaid on optical image data viewed using the surgical microscope. A selected location for optical scanning may also be displayed and controlled using the scanning controller.
A hydraulically-driven Intra-Ocular Lens insertion tool (112) includes a body (202), a hydraulic chamber (204) within the body, a first fluid port (208), a second fluid port (210). Fluid may be pumped in through an irrigation line (220) connected to the hydraulic chamber through the first fluid port and/or an aspiration line (222) can be connected to the hydraulic chamber through the second fluid port. A piston (206) is positioned within the hydraulic chamber and arranged to move within the hydraulic chamber in response to the introduction or removal of fluid from the hydraulic chamber. An elongated member (212) that includes a distal end (214) comprising an intra-ocular lens interface (216) and a proximal end (218) is connected to the piston such that movement of the piston within the hydraulic chamber causes corresponding movement of the elongated member. The hydraulically-driven Intra-Ocular Lens insertion tool can be connected to a surgical console (102).
Optical coherence tomography (OCT) scan data is used to automatically detect and characterize vitreoretinal membranes in a spatially precise manner to generate a mask image. The mask image may characterize various aspects of a vitreoretinal membrane. The mask image is then overlaid with an optical image of the retina to enable visualization of the vitreoretinal membrane.
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
100.
METHOD FOR PRODUCING CONTACT LENSES WITH DURABLE LUBRICIOUS COATINGS THEREON
The invention is related to a method for producing silicone hydrogel contact lenses with a stable lubricious hydrogel coating thereon. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon.
brevets
