A surface coating method comprises heating a coating solution comprising a gelling agent, at least one sulfate salt and water to a temperature above the melting temperature of the gelling agent but below 100C. The heated coating solution is applied onto a plastic surface (12). The coating solution is dried on the plastic surface (12) to obtain a pre-coated plastic surface, onto which a liquid hydrogel is applied. The liquid hydrogel is solidified to form a solid hydrogel (30) adhering to the pre-coated plastic surface. The surface coating (20) enhances the adherence between the solid hydrogel (30) and the plastic surface (12).
B32B 27/08 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique d'une résine synthétique d'une sorte différente
C08J 3/215 - Formation de mélanges de polymères avec des additifs, p. ex. coloration en présence d'une phase liquide le polymère étant prémélangé avec une phase liquide au moins un additif étant également prémélangé avec une phase liquide
C08K 3/30 - Composés contenant du soufre, du sélénium ou du tellure
A cassette assembly (1) comprises a cover (100), two cassette halves (200A, 200B) and a slider (300) comprising multiple test chambers (302). The cassette halves (200A, 200B) comprise waste tanks (230) in fluid connection with reservoirs (240), prefilled in one of the cassette halves (200A, 200B) with test agents. The particular design of the cassette halves (200A, 200B) enable forming predefined 5 volumes of liquid to achieve predefined concentrations of the test agents in the reservoirs (240) in one of the cassette halves (200A, 200B) and liquid in the reservoirs (240) in the other of the cassette halves (200A, 200B). Gradients of the test agents can then be established over the multiple test chambers (302).
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
A cassette assembly (1) comprises a cover (100), two cassette halves (200A, 200B) and a slider (300) comprising multiple test chambers (302). The cassette halves (200A, 200B) comprise waste tanks (230) in fluid connection with reservoirs (240), prefilled in one of the cassette halves (200A, 200B) with test agents. The particular design of the cassette halves (200A, 200B) enable forming predefined 5 volumes of liquid to achieve predefined concentrations of the test agents in the reservoirs (240) in one of the cassette halves (200A, 200B) and liquid in the reservoirs (240) in the other of the cassette halves (200A, 200B). Gradients of the test agents can then be established over the multiple test chambers (302).
A fluidic device has a culture chamber configured to house a 3D culture matrix comprising a culture of microorganisms. A concentration gradient of a test substance is established over the 3D culture matrix by providing respective fluid flows at different end portions of the culture chamber and comprising different concentrations of the test substance. The response of the microorganisms to the test substance is determined based on the position of a border zone in the 3D culture matrix.
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
C12M 1/16 - Appareillage pour l'enzymologie ou la microbiologie contenant ou adaptés pour contenir des milieux solides
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Chemical and biological reagents for medical and veterinary use; diagnostic preparations, substances, test reagents and reagents for medical and veterinary purposes and for medical and veterinary use; medical diagnostic reagents and samples for testing blood Diagnostic apparatus and instruments for analyzing cellular responses for medical and veterinary use; electric instruments for medical and veterinary use for use in the diagnosis of blood
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Chemical and biological reagents for medical and veterinary use; Diagnostic aids, preparations, substances, test reagents and reagents for medical and veterinary purposes and for medical and veterinary use; Medical diagnostic reagents and samples for testing blood. Diagnostic apparatus and instruments for medical and veterinary use; Electric instruments for medical and veterinary use for use in the diagnosis of blood.
A fluidic device (1) has a culture chamber (10) configured to house a 3D culture matrix (2) comprising a culture of microorganisms (6). A concentration gradient of a test substance is established over the 3D culture matrix (2) by providing respective fluid flows at different end portions (12, 14) of the culture chamber (10) and comprising different concentrations of the test substance. The response of the microorganisms (6) to the test substance is determined based on the position of a border zone (5) in the 3D culture matrix (2).
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
C12M 1/16 - Appareillage pour l'enzymologie ou la microbiologie contenant ou adaptés pour contenir des milieux solides
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
A fluidic device (1) has a culture chamber (10) configured to house a 3D culture matrix (2) comprising a culture of microorganisms (6). A concentration gradient of a test substance is established over the 3D culture matrix (2) by providing respective fluid flows at different end portions (12, 14) of the culture chamber (10) and comprising different concentrations of the test substance. The response of the microorganisms (6) to the test substance is determined based on the position of a border zone (5) in the 3D culture matrix (2).
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
A microfluidic capsule (1) comprises a top lid (100), a middle piece (200) and a bottom piece (300) to be assembled to enclose a microfluidic substrate (400) for analysis of cells and biochemical reactions. The middle piece (200) comprises support structures in the form of support pillars (250) and walls (240) around a central light window (220) to provide mechanical support and prevent tension-induced structural deformations. When fully assembled, light windows (120, 220, 230) in the top lid (100), middle piece (200) and bottom piece (300) allows inspection of biological and/or biochemical samples positioned in the enclosed microfluidic substrate (400).
A microfluidic capsule (1) comprises a top lid (100), a middle piece (200) and a bottom piece (300) to be assembled to enclose a microfluidic substrate (400) for analysis of cells and biochemical reactions. The middle piece (200) comprises support structures in the form of support pillars (250) and walls (240) around a central light window (220) to provide mechanical support and prevent tension-induced structural deformations. When fully assembled, light windows (120, 220, 230) in the top lid (100), middle piece (200) and bottom piece (300) allows inspection of biological and/or biochemical samples positioned in the enclosed microfluidic substrate (400).
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
Produits et services
Chemicals, bio chemicals and reagents used industry and
science; diagnostic preparations, not for medical or
veterinary use; diagnostic assays, not for medical or
veterinary use. Chemical reagents for medical or veterinary use; diagnostic
preparations for medical or veterinary use; diagnostic test
kits for medical or veterinary use. Diagnostic apparatus, not for medical purposes; scientific
and electrical apparatus and instruments for the study and
manipulation of biological cells and compilation of cell
related measuring data.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
09 - Appareils et instruments scientifiques et électriques
Produits et services
Chemicals, biochemicals and reagents for industrial and scientific use in microfluidic systems; diagnostic preparations and diagnostic assays for use in microfluidic systems, not for medical or veterinary use Diagnostic, scientific and electrical apparatus and instruments whose functions are based upon fluidic flows in microchannels, for studies and manipulation of biological cells and compilation of cell related measuring data, not for medical use
A fluidic culture device (100) comprises a substrate (101) of transparent polymer material with an open culture chamber (110) in the form of a hollow in a bottom surface (102) of the substrate (101). Open fluid channels (120, 130) flank the culture chamber (110) and have inlets (140, 150) and outlets (160) in a top or end surface (104, 106) of the substrate (101). Removable channel plugs (180, 190) are temporarily arranged in the portions of the fluid channels (120, 130) adjacent the culture chamber (110) to prevent culture matrix material poured into the culture chamber (110) from entering and blocking the fluid channels (120, 130). When assembling an operational culture system (230), a biological sample (210) is introduced in the culture matrix (200) and the channel plugs (180, 190) are removed. A transparent cover disk (220) is reversibly attached to the bottom surface (102) to enclose the culture chamber (110) and the fluid channels (120, 130). A gradient is established over the culture chamber (110) by entering fluids having different concentrations of a substance in the fluid channels (120, 130).
