Produits et services

Glucosides; amino acids for industrial purposes; amino acids for scientific purposes; polyols; propylene glycol; sugar alcohol; organic acid salts; tartaric acid; succinic acid; citric acid; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of cosmetics; antioxidants for use in the manufacture of cosmetics; antioxidants for use in the manufacture of pharmaceuticals; chemical additives for use in the manufacture of cosmetics.

Produits et services

Glucosides; amino acids for industrial purposes; amino acids for scientific purposes; polyols; propylene glycol; sugar alcohol; organic acid salts; tartaric acid; succinic acid; citric acid; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of cosmetics; antioxidants for use in the manufacture of cosmetics; antioxidants for use in the manufacture of pharmaceuticals; chemical additives for use in the manufacture of cosmetics.

Abrégé

Provided in the present invention are a genetically modified pantoic-acid-producing strain having, or having enhanced, NADH-dependent acetohydroxy acid isomeroreductase, a method for producing same, a method for producing D-pantoic acid by using same, and the use thereof in the production of D-pantoic acid.

Classes IPC  ?

• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12P 7/42 - Acides hydroxycarboxyliques
• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12R 1/19 - Escherichia coli

Produits et services

Dietetic foods and beverages adapted for medical use; Food for babies; Nutritional supplements; Deodorants for refrigerators; Depuratives for the body; Amino acids for veterinary purposes; Dietary supplements for animals; Medicated shampoos for pets; Medicated animal feed; Teeth filling material; Dietary and nutritional supplements for endurance sports; Nutritional supplements in the nature of nutritionally fortified soft chews; Nutritional supplements for boosting energy and promoting healthy skin; Liquid nutritional supplement; Powdered nutritional supplement concentrate; Nutritional supplement energy bars; Nutritional supplements, namely, probiotic compositions; Powdered nutritional supplement drink mix; Beverages containing probiotics, prebiotics and vitamin C for use as a nutritional supplement; Nutritional supplements for cats, dogs, pets and livestock; Nutritional supplements in the form of capsules, tablets, caplets, powder, syrups, gummies and gels

Produits et services

Animal albumen [raw material]; carbonic hydrates; tensio-active agents; surface-active chemical agents; salts [chemical preparations]; biochemical catalysts; chemical additives for use in the manufacture of cosmetics; antioxidants for use in the manufacture of cosmetics; plant extracts for use in the manufacture of cosmetics; vitamins for use in the manufacture of cosmetics.

Produits et services

Succinic acid; propylene glycol; sugar alcohol; vitamins for use in the manufacture of cosmetics; plant extracts for use in the manufacture of cosmetics; tensio-active agents; carbonic hydrates; animal albumen [raw material]; salts [chemical preparations]; surface-active chemical agents; biochemical catalysts; chemical additives for use in the manufacture of cosmetics; antioxidants for use in the manufacture of cosmetics.

Produits et services

(1) Animal albumen [raw material]; carbonic hydrates; tensio-active agents; surface-active chemical agents; salts [chemical preparations]; biochemical catalysts; chemical additives for use in the manufacture of cosmetics; antioxidants for use in the manufacture of cosmetics; plant extracts for use in the manufacture of cosmetics; vitamins for use in the manufacture of cosmetics.

Produits et services

Succinic acid; propylene glycol; sugar alcohols for industrial purposes; tensio-active agents being chemicals for industrial purposes; carbonic hydrates; animal albumen as raw materials, other than for medical or veterinary purposes; salts being chemical preparations for industrial purposes; surface active chemical compounds for general use in the industrial arts, namely, as wetting, spreading, emulsifying, dispersing and penetrating agents; biochemical catalysts

Produits et services

(1) Succinic acid; propylene glycol; sugar alcohol; vitamins for use in the manufacture of cosmetics; plant extracts for use in the manufacture of cosmetics; tensio-active agents; carbonic hydrates; animal albumen [raw material]; salts [chemical preparations]; surface-active chemical agents; biochemical catalysts; chemical additives for use in the manufacture of cosmetics; antioxidants for use in the manufacture of cosmetics.

Abrégé

The present invention provides an mreC mutant and use thereof in L-valine fermentative production. The mreC mutant is a protein obtained by mutating proline at position 150 in the wild-type mreC amino acid sequence into leucine. The introduction of an mreC point mutation into the microbial genome, i.e., a C-to-T mutation at position 449 of the coding region in the wild-type mreC gene nucleotide sequence, can significantly improve the production capacity and biomass of an engineering strain of a high valine production. The knock-out and introduction of related enzyme genes of the L-valine anaerobic fermentation pathway further provide proper carbon metabolic flows and reducing capacity balance control in the L-valine production process. By the coordinative regulation of multiple genes, a metabolic pathway suitable for L-valine fermentative production is formed, thus achieving a high-level synthesis of L-valine in microorganisms.

Classes IPC  ?

• C07K 14/245 - Escherichia (G)
• C12N 15/31 - Gènes codant pour des protéines microbiennes, p. ex. entérotoxines
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12P 13/08 - LysineAcide diaminopiméliqueThréonineValine

Abrégé

Related are a recombinant microorganism for producing L-valine, a construction method and an application thereof. Through enhancing amino acid dehydrogenase activity of L-valine fermentation strain, and/or activating an Entner-Doudoroff (ED) metabolic pathway, a problem in L-valine fermentation process that reducing power is unbalanced is solved, thereby the titer and yield of L-valine produced by Escherichia coli are improved, and L-valine was produced by one-step anaerobic fermentation.

Classes IPC  ?

• C12P 13/08 - LysineAcide diaminopiméliqueThréonineValine
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 1/20 - BactériesLeurs milieux de culture
• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)

Abrégé

Related are a recombinant microorganism for producing L-valine, a construction method and an application thereof. Through transferring an amino acid dehydrogenase gene and/or activating activity of a transhydrogenase and/or a NAD kinase, reducing power of NADPH in cell is increased, the titer and yield of L-valine generated by Escherichia coli are improved, and the production of L-valine by one-step anaerobic fermentation is achieved.

Classes IPC  ?

• C12P 13/08 - LysineAcide diaminopiméliqueThréonineValine
• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
• C12N 1/20 - BactériesLeurs milieux de culture
• C12N 9/88 - Lyases (4.)
• C12N 9/10 - Transférases (2.)

Abrégé

Related are a recombinant microorganism for producing L-valine, a construction method and an application thereof. Through transferring an acetohydroxy acid reductoisomerase gene and/or an amino acid dehydrogenase gene into a microorganism, and enhancing activity of an acetohydroxy acid reductoisomerase and/or an amino acid dehydrogenase, the titer and yield of L-valine generated by Escherichia coli may be improved, and L-valine was produced by one-step anaerobic fermentation.

Classes IPC  ?

• C12P 13/08 - LysineAcide diaminopiméliqueThréonineValine
• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome

Produits et services

Vitamin preparations; tonics [medicines]; medicines for human purposes; ointments for pharmaceutical purposes; medicinal ointments; disinfectants for hygiene purposes; dietetic foods adapted for medical purposes; air purifying preparations; preparations for destroying noxious animals.

Produits et services

Filtering preparations for the beverages industry; chemical preparations for smoking meat; milk ferments for chemical purposes; artificial sweeteners [chemical preparations]; enzymes for the food industry; glucose for the food industry; acids; enzyme preparations for industrial purposes; enzymes for industrial purposes; lactic acid; tensio-active agents; methacrylic acid; succinic acid; diastase for industrial purposes; ferments for chemical purposes; fatty acids; chemical substances for preserving foodstuffs; chemicals for fermenting wine; saccharin; beer-clarifying and preserving agents.

Produits et services

Filtering preparations for the beverages industry; chemical preparations for smoking meat; milk ferments for chemical purposes; artificial sweeteners [chemical preparations]; enzymes for the food industry; glucose for the food industry; acids; enzyme preparations for industrial purposes; enzymes for industrial purposes; lactic acid; tensio-active agents; methacrylic acid; succinic acid; diastase for industrial purposes; ferments for chemical purposes; fatty acids; chemical substances for preserving foodstuffs; oenological bactericides [chemical preparations used in wine making]; saccharin; beer-clarifying and preserving agents.

Produits et services

Ointments for pharmaceutical purposes; medicinal ointments; disinfectants for hygiene purposes; medicines for human purposes; air purifying preparations; preparations for destroying noxious animals.

Produits et services

Hemorrhoidal ointments; anti-itch ointment; mercurial ointments for medical use; anti-inflammatory ointments; medicated ointments for treating dermatological conditions; medicated sunburn ointments; disinfectants for hygiene purposes; medicines for intestinal disorders; medicines for the treatment of cardiovascular and cerebrovascular diseases; antiallergic medicines; pharmaceutical preparations for skin care; pharmaceutical preparations for treating hypertension; air purifying preparations; preparations for destroying noxious animals

Produits et services

Chemical preparations in the nature of filtering materials for use in the beverages industry; chemical preparations for smoking meat; milk ferments being chemicals for industrial purposes; artificial sweeteners being chemical preparations; enzymes for the food industry; glucose for the food industry; nitric acid; citric acid for industrial purposes; boric acid for industrial purposes; carbonic acid; sulfuric acid; enzymes for industrial purposes; lactic acid; chemical preparations for use as tensio-active agents in manufacture of cosmetics products, industrial products, and consumer and household products; methacrylic acid; succinic acid; diastase for industrial purposes; ferments being chemicals for industrial purposes; fatty acids for industrial purposes; chemical preparations for preserving foodstuffs; chemicals for fermenting wine; saccharin; beer-clarifying and preserving agents

Produits et services

Chemical preparations in the nature of filtering materials for use in the beverages industry; chemical preparations for smoking meat; milk ferments being chemicals for industrial purposes; artificial sweeteners; enzymes for the food industry; glucose for the food industry; nitric acid; citric acid for industrial purposes; boric acid for industrial purposes; carbonic acid; sulfuric acid; enzymes for industrial purposes; lactic acid; chemical preparations for use as tensio-active agents in manufacture of cosmetics products, industrial products, and consumer and household products; methacrylic acid; succinic acid; diastase for industrial purposes; ferments being chemicals for industrial purposes; fatty acids for industrial purposes; chemical preparations for preserving foodstuffs; oenological bactericides used in wine making; saccharin; beer-clarifying and preserving agents

Produits et services

Vitamin preparations; natural herbal supplements; medicines for intestinal disorders; medicines for the treatment of cardiovascular and cerebrovascular diseases; antiallergic medicines; pharmaceutical preparations for skin care; pharmaceutical preparations for treating hypertension; hemorrhoidal ointments; anti-itch ointment; mercurial ointments for medical use; anti-inflammatory ointments; medicated ointments for treating dermatological conditions; medicated sunburn ointments; disinfectants for hygiene purposes; dietetic foods adapted for medical purposes; air purifying preparations; preparations for destroying noxious animals

Abrégé

Provided are a recombinant microorganism for producing L-valine, a construction method therefor, and an application thereof. By introducing an amino acid dehydrogenase gene and/or activating the activity of transhydrogenase and/or NAD kinase, cell NADPH reducing power is increased, the yield and conversion rate of L-valine produced by Escherichia coli are improved, and one-step anaerobic fermentation of L-valine is achieved.

Classes IPC  ?

• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 9/90 - Isomérases (5.)
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12N 15/53 - Oxydoréductases (1)
• C12N 15/77 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour CorynebacteriumVecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Brevibacterium
• C12P 13/08 - LysineAcide diaminopiméliqueThréonineValine

Abrégé

Provided are a recombinant microorganism for producing L-valine, a construction method therefor and the use thereof. By means of enhancing the activity of amino acid dehydrogenase in L-valine fermentation strains, and/or activating the Entner-Doudoroff (ED) pathway, the problem of the reducing power in the fermentation process of L-valine being unbalanced is solved, thereby improving the yield and conversion rate of L-valine produced by using Escherichia coli and realizing the one-step anaerobic fermentation of L-valine.

Classes IPC  ?

• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12P 13/08 - LysineAcide diaminopiméliqueThréonineValine
• C12N 15/53 - Oxydoréductases (1)
• C12R 1/19 - Escherichia coli

Abrégé

A recombinant microorganism for producing L-valine, a construction method therefor, and an application thereof. By introducing an acetohydroxy acid reductoisomerase gene and/or an amino acid dehydrogenase gene into a microorganism, and improving the activity of acetohydroxy acid reductoisomerase and the activity of amino acid dehydrogenase, the yield and conversion rate of L-valine produced by Escherichia coli can be increased, and one-step anaerobic fermentation of L-valine can be achieved.

Classes IPC  ?

• C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12P 13/08 - LysineAcide diaminopiméliqueThréonineValine
• C12R 1/13 - Brevibacterium

Abrégé

Provided are an engineering bacteria and a method for producing beta-alanine. With respect to the original bacteria, the engineering bacteria is capable of overexpressing the alpha-carboxylase of L-aspartic acid of Bacillus subtilis as shown in sequence 6, or overexpressing a polypeptide having at least 60%, preferably 80%, more preferably 90%, further preferably 95% and most preferably 98% or even 99% homology with the enzyme and having the enzyme activity.

Classes IPC  ?

• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12P 13/06 - AlanineLeucineIsoleucineSérineHomosérine
• C12R 1/19 - Escherichia coli

Abrégé

Disclosed are a bacterial strain capable of producing a large amount of L-alanine and being tolerant to tap water and a construction method thereof. The method is to obtain the recombinant bacterium by mutating gene lon and gene clpA in a starting bacterium; during mutation of the gene lon in the starting bacterium, C at position 1310 from the 5' end in the nucleotide sequence of gene lon in the starting bacterium is mutated to A; and during mutation of the gene clpA in the starting bacterium, T at position 1895 from the 5' end in the nucleotide sequence of gene clpA in the starting bacterium is mutated to G. In the present invention, the recombinant bacterium XZ-A47 is obtained by mutating the gene lon and the gene clpA in the engineered Escherichia coli bacterium XZ-A26.

Classes IPC  ?

• C12N 15/09 - Technologie d'ADN recombinant
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12P 13/06 - AlanineLeucineIsoleucineSérineHomosérine
• C12R 1/19 - Escherichia coli

Abrégé

Disclosed are a bacterial strain capable of producing L-alanine and being tolerant to tap water, and a construction method therefor. Provided is a method for constructing a recombinant bacterium, comprising mutating a clpA gene in a starting bacterium to obtain the recombinant bacterium; during mutation of the clpA gene in the starting bacterium, T at position 1895 from the 5' end of a nucleotide sequence of the clpA gene in the starting bacterium is mutated into G. The recombinant bacterium XZ-A45 obtained by the present invention can produce large amounts of L-alanine in a fermentation culture medium formulated with tap water.

Classes IPC  ?

• C12N 15/09 - Technologie d'ADN recombinant
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12P 13/06 - AlanineLeucineIsoleucineSérineHomosérine
• C12R 1/19 - Escherichia coli