Abrégé

The present invention relates to a composition for preventing or treating of hyperproliferative vascular disease containing the extract of the thorns of Gleditsia sinensis as the active ingredient. The composition of the present invention, containing the extract of the thorns of Gleditsia sinensis as the active ingredient, exhibit excellent cytotoxicity to smooth muscle cells, suppresses the expression and activity of cell cycle regulators Cdc25c, Cdc2 and cycline B, and arrests the cell cycle at the G2/M stage. By inhibiting the activity of transcription factors NF-κB and AP-1, the composition suppresses the activity of MMP-9 in smooth muscle cells and effectively blocks cell migration. Furthermore, by promoting the activity of mitogen-activated protein kinases (MAPK) such as ERK, p38MAP kinase and JNK, the composition induces cell apoptosis. In addition, the composition of the present invention has no safety issues because it uses the extract of the thorns of Gleditsia sinensis as the active ingredient, which has long been used in Chinese herbal medicine.

Classes IPC  ?

• A61K 36/483 - Gleditsia (caroube)
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A23L 1/30 - contenant des additifs (A23L 1/308 a priorité);;

Abrégé

The present invention relates to a composition for preventing and treating colon cancer containing extract from the thorn of Gleditsia sinensis as an active ingredient. The disclosed composition is highly cytotoxic to colon cancer cells and arrests the cell cycle at G2/M phase, suppressing expression and activation of Cdc25c, Cdc2, and cyclin B which are cell cycle regulators. The composition interferes with the activation of transcription factors, NF-κb and AP-1, inhibits the activation of MMP-9 in colon cancer cells and effectively suppresses metastasis of cancer cells. The composition also promotes the activation of MAPK (mitogen-activated protein kinase), which includes Erk, p38 MAPKinase and JNK, and induces apoptosis of cancer cells. The composition has excellent anticancer activity even on the individual animal level. In addition, the disclosed composition is extremely safe since it contains extract from the thorn of Gleditsia sinensis as the active ingredient, which has been used in oriental medicine for a long time.

Classes IPC  ?

• A61K 36/483 - Gleditsia (caroube)